miabis.xsd

<?xml version="1.0"?>
<xs:schema xmlns="http://www.bbmri-eric.eu/miabis"
           xmlns:m="http://www.bbmri-eric.eu/miabis"
           xmlns:xs="http://www.w3.org/2001/XMLSchema"
           targetNamespace="http://www.bbmri-eric.eu/miabis"
           elementFormDefault="qualified"
           attributeFormDefault="unqualified">

    <xs:import namespace="http://www.w3.org/XML/1998/namespace"/>

    <xs:simpleType name="Age">
        <xs:restriction base="xs:positiveInteger">
            <xs:maxInclusive value="54750">
                <xs:annotation>
                    <xs:documentation>
                        The maximum value is limited to 150 years expressed in
                        days.
                    </xs:documentation>
                </xs:annotation>
            </xs:maxInclusive>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="Country">
        <xs:annotation>
            <xs:documentation>
                Datatype for the Country code. This should be a two-letter code
                as defined in ISO 3166-1 alpha-2.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:ID">
            <xs:pattern value="[A-Z]{2}"/>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="URL">
        <xs:annotation>
            <xs:documentation>
                Datatype for an URL. The value should be a qualified URL
                including protocol, hostname and optionally a path and
                parameters, e.g.:
                http://bbmri-wiki.wikidot.com/en:dataset-biobank
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:anyURI">
            <xs:pattern value="^(http|https)://.+"/>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="Email">
        <xs:annotation>
            <xs:documentation>
                Datatype for an Email address. The value should be an address
                consisting of a local part and a domain part as defined in
                RFC 2822, e.g.:
                info@bbmri-eric.eu
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:pattern value="[^@]+@[^\.]+\..+"/>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="text">
        <xs:annotation>
            <xs:documentation>
                Datatype for the description. The description should be one
                or more paragraphs of text limited to a maximum of 2000
                characters.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:maxLength value="2000"/>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="TimeUnit">
        <xs:annotation>
            <xs:documentation>
                Enumeration of the valid units of time to express the age of
                a participant at the time of sampling.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:enumeration value="year">
                <xs:annotation>
                    <xs:documentation>
                        The period of time that it takes for Earth to make a
                        complete revolution around the sun, approximately 365
                        days.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="week">
                <xs:annotation>
                    <xs:documentation>
                        Any period of seven consecutive days.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="day">
                <xs:annotation>
                    <xs:documentation>
                        The time for Earth to make a complete rotation on its
                        axis; ordinarily divided into twenty-four hours.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="DataCategory">
        <xs:annotation>
            <xs:documentation>
                MIABIS-2.0-13: Enumeration of the valid data catagories from
                which data is available in a sample collection or study.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:enumeration value="Biological samples">
                <xs:annotation>
                    <xs:documentation>
                        Biological samples are collected from the participants
                        in the sample collection/study.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Survey data">
                <xs:annotation>
                    <xs:documentation>
                        Information from surveys are collected from the
                        participants.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Imaging data">
                <xs:annotation>
                    <xs:documentation>
                        Imaging data are collected from the participants.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Medical records">
                <xs:annotation>
                    <xs:documentation>
                        Medical records are collected from the participants.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="National registries">
                <xs:annotation>
                    <xs:documentation>
                        Register data is associated to the participants.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Genealogical records">
                <xs:annotation>
                    <xs:documentation>
                        Genealogical records are associated with the
                        participants.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Physiological/Biochemical measurements">
                <xs:annotation>
                    <xs:documentation>
                        Measurements/tests performed during a clinical/home
                        visit and from samples taken from donor.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Other">
                <xs:annotation>
                    <xs:documentation>
                        Other.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="MaterialType">
        <xs:annotation>
            <xs:documentation>
                MIABIS-2.0-14: Enumeration of the valid types of biospecimens
                in a sample collection or study.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:enumeration value="RNA">
                <xs:annotation>
                    <xs:documentation>
                        One of two types of nucleic acid made by cells. RNA
                        contains information that has been copied from DNA
                        (the other type of nucleic acid). Cells make several
                        different forms of RNA, and each form has a specific
                        job in the cell. Many forms of RNA have functions
                        related to making proteins. RNA is also the genetic
                        material of some viruses instead of DNA. RNA can be
                        made in the laboratory and used in research studies.
                        Also called ribonucleic acid.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="DNA">
                <xs:annotation>
                    <xs:documentation>
                        A long linear double-stranded polymer formed from
                        nucleotides attached to a deoxyribose backbone and found
                        in the nucleus of a cell; associated with the
                        transmission of genetic information.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="cDNA/mRNA">
                <xs:annotation>
                    <xs:documentation>
                        Single-stranded DNA that is complementary to messenger
                        RNA or DNA that has been synthesized from messenger RNA
                        by reverse transcriptase/A class of RNA molecule
                        containing protein-coding information in its nucleotide
                        sequence that can be translated into the amino acid
                        sequence of a protein.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="microRNA">
                <xs:annotation>
                    <xs:documentation>
                        A type of RNA found in cells and in blood. MicroRNAs are
                        smaller than many other types of RNA and can bind to
                        messenger RNAs (mRNAs) to block them from making
                        proteins. MicroRNAs are being studied in the diagnosis
                        (NCI) and treatment of cancer.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Whole blood">
                <xs:annotation>
                    <xs:documentation>
                        Blood that has not been separated into its various
                        components; blood that has not been modified except for
                        the addition of an anticoagulant.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Peripheral blood cells">
                <xs:annotation>
                    <xs:documentation>
                        A general term describing the three cellular components
                        of blood (white blood cells, red blood cells, and
                        platelets), all which are made in the bone marrow.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Plasma">
                <xs:annotation>
                    <xs:documentation>
                        Plasma is the fluid (acellular) portion of the
                        circulating blood, as distinguished from the serum that
                        is the fluid portion of the blood obtained by removal of
                        the fibrin clot and blood cells after coagulation.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Serum">
                <xs:annotation>
                    <xs:documentation>
                        The clear portion of the blood that remains after the
                        removal of the blood cells and the clotting proteins.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Tissue, cryo preserved">
                <xs:annotation>
                    <xs:documentation>
                        An anatomical structure consisting of similarly
                        specialized cells and intercellular matrix, aggregated
                        according to genetically determined spatial
                        relationships, performing a specific function.
                        Preserved by freezing in liquid nitrogen.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Tissue, paraffin preserved">
                <xs:annotation>
                    <xs:documentation>
                        Tissue that is preserved and embedded in paraffin.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Cell lines">
                <xs:annotation>
                    <xs:documentation>
                        Cells of a single type (human, animal, or plant) that
                        have been adapted to grow continuously in the laboratory
                        and are used in research.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Urine">
                <xs:annotation>
                    <xs:documentation>
                        The fluid that is excreted by the kidneys. It is stored
                        in the bladder and discharged through the urethra.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Saliva">
                <xs:annotation>
                    <xs:documentation>
                        A clear liquid secreted into the mouth by the salivary
                        glands and mucous glands of the mouth; moistens the
                        mouth and starts the digestion of starches.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Faeces">
                <xs:annotation>
                    <xs:documentation>
                        The material discharged from the bowel during
                        defecation. It consists of undigested food, intestinal
                        mucus, epithelial cells, and bacteria.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Pathogen">
                <xs:annotation>
                    <xs:documentation>
                        A biological agent causing disease; a disease producer
                        e.g. virus, bacterium, prion, other microorganism etc.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Other">
                <xs:annotation>
                    <xs:documentation>
                        Any other type of material taken from a biological
                        entity, e.g. amniotic fluid, cerebrospinal fluid (CSV),
                        mitochondrial RNA.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="Temperature">
        <xs:annotation>
            <xs:documentation>
                MIABIS-2.0-15: Enumeration of the valid storage temperatures in
                a sample collection or study.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:enumeration value="RT">
                <xs:annotation>
                    <xs:documentation>
                        Storage at room temperature.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="2&#xB0;C to 10&#xB0;C">
                <xs:annotation>
                    <xs:documentation>
                        Storage between 2&#xB0;C and 10&#xB0;C.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="-18&#xB0;C to -35&#xB0;C">
                <xs:annotation>
                    <xs:documentation>
                        Storage between -18&#xB0;C and -35&#xB0;C.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="-60&#xB0;C to -85&#xB0;C">
                <xs:annotation>
                    <xs:documentation>
                        Storage between -60&#xB0;C and -85&#xB0;C.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="LN">
                <xs:annotation>
                    <xs:documentation>
                        Storage in liquid nitrogen, -150&#xB0;C to -196&#xB0;C.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Other">
                <xs:annotation>
                    <xs:documentation>
                        Any other temperature or long time storage information.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="Sex">
        <xs:annotation>
            <xs:documentation>
                MIABIS-2.0-09: Enumeration of the valid sexes of the
                participants in a sample collection or study.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:enumeration value="Male">
                <xs:annotation>
                    <xs:documentation>
                        Male.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Female">
                <xs:annotation>
                    <xs:documentation>
                        Female.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Undifferentiated">
                <xs:annotation>
                    <xs:documentation>
                        Undifferentiated, the gender could not be uniquely
                        identified such as hermaprhodite.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Unknown">
                <xs:annotation>
                    <xs:documentation>
                        A proper value is applicable but not known.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="CollectionType">
        <xs:annotation>
            <xs:documentation>
                MIABIS-2.0-16 / MIABIS-2.0-19: Enumeration of the types
                collections.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:enumeration value="Case-control">
                <xs:annotation>
                    <xs:documentation>
                        A case-control study design compares two groups of
                        subjects: those with the disease or condition under
                        study (cases) and a very similar group of subjects who
                        do not have the disease or condition (controls).
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Cohort">
                <xs:annotation>
                    <xs:documentation>
                        A form of longitudinal study for the analysis of risk
                        factors following a group of people who do not have a
                        disease, and uses correlations to determine the absolute
                        risk of subject contraction.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Cross-sectional">
                <xs:annotation>
                    <xs:documentation>
                        A type of observational study that involves data
                        collection from a population, or a representative
                        subset, at one specific point in time.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Longitudinal">
                <xs:annotation>
                    <xs:documentation>
                        Research studies involving repeated observations of the
                        same entity over time. In the biobank context,
                        longitudinal studies sample a group of people in a given
                        time period, and study them at intervals by the
                        acquisition and analyses of data and/or samples over
                        time.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Twin-study">
                <xs:annotation>
                    <xs:documentation>
                        Twin studies measure the contribution of genetics
                        (as opposed to environment) to a given trait or
                        condition of interest.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Quality control">
                <xs:annotation>
                    <xs:documentation>
                        A quality control testing study design type is where
                        some aspect of the experiment is quality controlled for
                        the purposes of quality assurance.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Population-based">
                <xs:annotation>
                    <xs:documentation>
                        Study done at the population level or among the
                        population groups, generally to find the cause,
                        incidence or spread of the disease or to see the
                        response to the treatment, nutrition or environment.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Disease specific">
                <xs:annotation>
                    <xs:documentation>
                        A study or biobank for which material and information is
                        collected from subjects that have already developed a
                        particular disease.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Birth cohort">
                <xs:annotation>
                    <xs:documentation>
                        A cohort study for which the subjects are followed from
                        the time of birth usually including information about
                        gestation and follow up.
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Other">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
        </xs:restriction>
    </xs:simpleType>

    <xs:simpleType name="InclusionCriteria">
        <xs:annotation>
            <xs:documentation>
                MIABIS-2.0-22: Enumeration of the criteria used for inclusion of
                (samples of) a participant in a study.
            </xs:documentation>
        </xs:annotation>
        <xs:restriction base="xs:string">
            <xs:enumeration value="Health status">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Hospital patient">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Use of medication">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Gravidity">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Age group">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Familial status">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Sex">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Country of residence">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Ethnic origin">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Population representative sampling">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Lifestyle/Exposure">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
            <xs:enumeration value="Other">
                <xs:annotation>
                    <xs:documentation>
                    </xs:documentation>
                </xs:annotation>
            </xs:enumeration>
        </xs:restriction>
    </xs:simpleType>

    <xs:complexType name="OntologyTerm">
        <xs:sequence>
            <xs:element name="ontology" type="xs:string">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-17A: Name of ontology used.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="version" type="xs:string" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-17B: Version of selected ontology.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="code" type="xs:string">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-17C: Code from the selected ontology.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="description" type="xs:string" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-17D: Description from the selected Ontology Code.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="id" type="xs:ID"/>
    </xs:complexType>

    <xs:complexType name="Disease">
        <xs:complexContent>
            <xs:extension base="OntologyTerm">
                <xs:sequence>
                    <xs:element name="freeText" type="text" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>
                                MIABIS-2.0-17E: Explanation about disease or
                                symptom in case of unknown disease or
                                insufficient information.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="ContactInformation">
        <xs:sequence>
            <xs:sequence minOccurs="0">
                <xs:element name="firstname" type="xs:string">
                    <xs:annotation>
                        <xs:documentation>
                            MIABIS-2.0-07-A: Textual string of letters denoting
                            the first name of the Contact.
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="lastname" type="xs:string">
                    <xs:annotation>
                        <xs:documentation>
                            MIABIS-2.0-07-B: Textual string of letters denoting
                            the last name of the Contact.
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:sequence>
            <xs:element name="phone" type="xs:string" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-07-C: Phone to the Contact including
                        international call prefix.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="email" type="Email" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-07-D: Email address of the Contact person.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:sequence minOccurs="0">
                <xs:element name="address" type="xs:string">
                    <xs:annotation>
                        <xs:documentation>
                            MIABIS-2.0-07-E: Street name and street number or
                            PO Box of the Contact person.
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="zip" type="xs:string">
                    <xs:annotation>
                        <xs:documentation>
                            MIABIS-2.0-07-F: ZIP or Postal code of the Contact
                            person.
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="city" type="xs:string">
                    <xs:annotation>
                        <xs:documentation>
                            MIABIS-2.0-07-G: City of the Contact person.
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="country" type="xs:IDREF">
                    <xs:annotation>
                        <xs:documentation>
                            MIABIS-2.0-07-H: Country of the Contact person.
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:sequence>
        </xs:sequence>
        <xs:attribute name="id" type="xs:ID"/>
    </xs:complexType>

    <xs:complexType name="ResearchInformation">
        <xs:complexContent>
            <xs:extension base="ContactInformation">
                <xs:sequence>
                    <xs:element name="juristicPerson" type="xs:string" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>
                                MIABIS-2.0-23A: Textual string of letters
                                denoting the juristic person e.g. a university,
                                concern, county council etc.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                    <xs:element name="department" type="xs:string" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>
                                MIABIS-2.0-23B: Department (e.g. division), or
                                corresponding affiliation of the Contact person.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                    <xs:element name="ORCID" type="URL" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>
                                MIABIS-2.0-23C: The persistent digital
                                identifier that distinguishes researchers.
                                As defined by ORCID.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="Biobank">
        <xs:sequence>
            <xs:element name="id" type="xs:ID">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-01: Textual string of letters starting with
                        the country code (according to standard ISO1366 alpha2)
                        followed by the underscore “_” and post-fixed by a
                        biobank ID or name specified by its juristic person
                        (nationally specific).
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="acronym" type="xs:string">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-02: Textual string of short name in use for
                        the biobank. If applicable.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="name" type="xs:string">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-03: Textual string of letters denoting the
                        name of the biobank in English.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="url" type="URL">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-04: Textual string of letters with the
                        complete http-address for the biobank URL.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="juristicPerson" type="xs:string">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-05: Textual string of letters denoting the
                        juristic person e.g. a university, concern, county
                        council etc. for the biobank.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="country" type="Country">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-06: ISO-standard (3166 alpha2), two letter
                        code for the country of the biobank.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="contactInformation" type="xs:IDREFS">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-07: Contact information for the contact
                        person of the biobank.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="description" type="text">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-08: Textual string of letters with a
                        description about the biobank in English.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="sampleCollections" type="xs:IDREFS" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>

                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="studies" type="xs:IDREFS" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>

                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="Study">
        <xs:sequence>
            <xs:element name="id" type="xs:ID">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-01: The unique ID or acronym of the study.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="name" type="xs:string">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-02: The name of the study in English.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="description" type="text">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-08: A description of the study aim.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="principalInvestigator" type="xs:string" maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-18: The name of the person responsible for the
                        study e.g. the principal investigator
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="contactInformation" type="xs:IDREFS">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-07: Contact information to the contact person
                        for the study.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="studyDesign" type="CollectionType" maxOccurs="10">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-19: The design of the study.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="sex" type="Sex" maxOccurs="4">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-09: The sex of the study participants.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="ageLow" type="Age">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-10: Age of the youngest study participant at time
                        of inclusion.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="ageHigh" type="Age">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-11: Age of the oldest study participant at time
                        of inclusion.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="ageUnit" type="TimeUnit">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-12: Unit defining Age Low and Age High.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="dataCategory" type="DataCategory" maxOccurs="8">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-13: The type of data that is associated with the
                        samples in the study.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="materialType" type="MaterialType" maxOccurs="15">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-14: The biospecimen saved from a biological
                        entity for propagation e.g. testing, diagnostics,
                        treatment or research purposes.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="totalNumberOfParticipants" type="xs:positiveInteger">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-20: Total number of individuals recruited to the
                        study.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="totalNumberOfDonors" type="xs:positiveInteger">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-21: Total number of individuals with biological
                        samples in the study.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="inclusionCriteria" type="InclusionCriteria" maxOccurs="12">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-22: Information on type of parameters that
                        determine which individuals will become study
                        participants.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="biobanks" type="xs:IDREFS" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>
                        The biobanks that store samples for this collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="sampleCollections" type="xs:IDREFS" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>
                        The subcollections of the sample collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="studies" type="xs:IDREFS" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>
                        The subcollections of the sample collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="SampleCollection">
        <xs:annotation>
            <xs:documentation>
                MIABIS Sample Collection.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence minOccurs="0" maxOccurs="1">
            <xs:element name="id" type="xs:ID">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-01: Sample Collection ID that also links the
                        sample collection to the hosting biobank or study.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="acronym" type="xs:string">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-02: Short name in use for the sample collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="name" type="xs:string">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-03: The name of the sample collection in english.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="description" type="text">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-08: A description of the sample collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="sex" type="Sex" maxOccurs="4">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-09: The sex of the individuals in the sample
                        collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="ageLow" type="Age">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-10: Age of youngest sample donor at time of
                        sample donation.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="ageHigh" type="Age">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-11: Age of oldest sample donor at time of sample
                        donation.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="ageUnit" type="TimeUnit">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-12: Unit defining Age Low and Age High.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="dataCategory" type="DataCategory" maxOccurs="8">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-13: The data catagories from which data is
                        available.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="materialType" type="MaterialType" maxOccurs="16">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-14: The biospecimen saved from a biological
                        entity for propagation e.g. testing, diagnostics,
                        treatment or research purposes.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="storageTemperature" type="Temperature" maxOccurs="6">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-15: The long term storage temperature a
                        the samples are stored after preparation.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="collectionType" type="CollectionType" maxOccurs="10">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-16: The type of the sample collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="diseases" type="xs:IDREFS">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-17: The diseases of main interest in the sample
                        collection, if any.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="contactInformation" type="xs:IDREFS">
                <xs:annotation>
                    <xs:documentation>
                        MIABIS-2.0-07: Contact information to the contact person for
                        the sample collection MIABIS-07 and MIABIS-22 of the PI.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="biobanks" type="xs:IDREFS">
                <xs:annotation>
                    <xs:documentation>
                        The biobanks that store samples for this collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="studies" type="xs:IDREFS">
                <xs:annotation>
                    <xs:documentation>
                        The studies that use samples from this collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="sampleCollections" type="xs:IDREFS">
                <xs:annotation>
                    <xs:documentation>
                        The subcollections of the sample collection.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:element name="miabis">
        <xs:annotation>
            <xs:documentation>
                Root container for the MIABIS data.
            </xs:documentation>
        </xs:annotation>
        <xs:complexType>
            <xs:sequence>
                <xs:element name="disease" type="Disease"
                            minOccurs="0" maxOccurs="unbounded">
                    <xs:annotation>
                        <xs:documentation>

                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="contactInformation" type="ContactInformation"
                            minOccurs="0" maxOccurs="unbounded">
                    <xs:annotation>
                        <xs:documentation>
                             MIABIS-2.0-07:
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="researchInformation" type="ResearchInformation"
                            minOccurs="0" maxOccurs="unbounded">
                    <xs:annotation>
                        <xs:documentation>
                             MIABIS-2.0-23:
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="biobank" type="Biobank"
                            minOccurs="0" maxOccurs="unbounded">
                    <xs:annotation>
                        <xs:documentation>
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="samplecollection" type="SampleCollection"
                            minOccurs="0" maxOccurs="unbounded">
                    <xs:annotation>
                        <xs:documentation>
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="study" type="Study"
                            minOccurs="0" maxOccurs="unbounded">
                    <xs:annotation>
                        <xs:documentation>
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:sequence>
        </xs:complexType>
    </xs:element>

</xs:schema>