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model_Fiedler_BMCSystBiol2016.xml
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model_Fiedler_BMCSystBiol2016.xml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model id="Fiedler_BMCSystBiol2016" name="Fiedler_BMCSystBiol2016">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>PEtab implementation of the model from Fiedler et al. (2016), BMC Systems Biology volume 10, Article number: 80</pre>
</body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#arFramework3">
<dc:creator>
<rdf:Bag>
<rdf:li rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Fiedler</vCard:Family>
<vCard:Given>Anna</vCard:Given>
</vCard:N>
</rdf:li>
</rdf:Bag>
</dc:creator>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2019-11-29T09:41:48Z</dcterms:W3CDTF>
</dcterms:created>
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2019-11-29T09:41:48Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/doi/10.1186/s12918-016-0319-7"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfUnitDefinitions>
<unitDefinition id="time" name="time">
<listOfUnits>
<unit kind="second" exponent="1" scale="0" multiplier="3600"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="cyt" spatialDimensions="3" size="1" constant="true"/>
</listOfCompartments>
<listOfSpecies>
<species id="RAF" name="RAF" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pRAF" name="pRAF" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="MEK" name="MEK" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pMEK" name="pMEK" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="ERK" name="ERK" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pERK" name="pERK" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
</listOfSpecies>
<listOfParameters>
<parameter id="ERK_total" value="1" constant="true"/>
<parameter id="K_1" value="1.00341445073941e-05" constant="true"/>
<parameter id="K_2" value="1.51138632474898" constant="true"/>
<parameter id="K_3" value="0.961738099369118" constant="true"/>
<parameter id="MEK_total" value="1" constant="true"/>
<parameter id="RAF_total" value="1" constant="true"/>
<parameter id="k10" value="0.0233013569106142" constant="true"/>
<parameter id="k11" value="149.597826906266" constant="true"/>
<parameter id="k2" value="1.22516651895562" constant="true"/>
<parameter id="k3" value="869.31180702032" constant="true"/>
<parameter id="k4" value="2.90831656859387" constant="true"/>
<parameter id="k5" value="578.350366636763" constant="true"/>
<parameter id="k6" value="3.61401250365661" constant="true"/>
<parameter id="tau1" value="0.251674841461275" constant="true"/>
<parameter id="tau2" value="0.0210740597705876" constant="true"/>
<parameter id="k1max" value="0.0233013569106142" constant="false"/>
<parameter id="Sorafenib" value="0" constant="false"/>
<parameter id="UO126" value="0" constant="false"/>
</listOfParameters>
<listOfInitialAssignments>
<initialAssignment symbol="RAF">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<ci> RAF_total </ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<power/>
<ci> k2 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> k2 </ci>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<power/>
<ci> MEK_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k5 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k5 </ci>
<ci> k6 </ci>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 4 </cn>
<ci> ERK_total </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
</apply>
</apply>
<cn type="rational"> 1 <sep/> 2 </cn>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> k2 </ci>
<ci> k4 </ci>
<ci> k6 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> k4 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k5 </ci>
<ci> k10 </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k6 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> k3 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> ERK_total </ci>
<ci> MEK_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k5 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k5 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> k3 </ci>
<ci> k5 </ci>
<ci> k10 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</initialAssignment>
<initialAssignment symbol="pRAF">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<power/>
<ci> k2 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> k2 </ci>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<apply>
<power/>
<ci> MEK_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k5 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k5 </ci>
<ci> k6 </ci>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 4 </cn>
<ci> ERK_total </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
</apply>
</apply>
<cn type="rational"> 1 <sep/> 2 </cn>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> k2 </ci>
<ci> k4 </ci>
<ci> k6 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> k4 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k5 </ci>
<ci> k10 </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k6 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> k3 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> ERK_total </ci>
<ci> MEK_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k5 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k5 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> k3 </ci>
<ci> k5 </ci>
<ci> k10 </ci>
</apply>
</apply>
</apply>
</math>
</initialAssignment>
<initialAssignment symbol="MEK">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<ci> MEK_total </ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci> MEK_total </ci>
<apply>
<power/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k2 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k2 </ci>
<apply>
<power/>
<ci> k4 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> MEK_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k5 </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> MEK_total </ci>
<apply>
<power/>
<ci> RAF_total </ci>
<cn type="integer"> 2 </cn>
</apply>
<apply>
<power/>
<ci> k3 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k5 </ci>
<ci> k6 </ci>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<apply>
<power/>
<ci> k6 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<apply>
<power/>
<ci> k10 </ci>
<cn type="integer"> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 2 </cn>
<apply>
<power/>
<ci> K_1 </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 4 </cn>
<ci> ERK_total </ci>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k2 </ci>
<ci> k3 </ci>
<ci> k4 </ci>
<ci> k5 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
</apply>
<cn type="rational"> 1 <sep/> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> k2 </ci>
<ci> k4 </ci>
<ci> k6 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> k4 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<ci> MEK_total </ci>
<ci> RAF_total </ci>
<ci> k3 </ci>
<ci> k6 </ci>
<ci> k10 </ci>
</apply>
<apply>
<times/>
<ci> K_1 </ci>
<apply>