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model_SalazarCavazos_MBoC2020.xml
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model_SalazarCavazos_MBoC2020.xml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level3/version2/core" level="3" version="2">
<model id="SalazarCavazos_MBoC2020" name="SalazarCavazos_MBoC2020">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#benchmark_models_petab">
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/doi/10.1091/mbc.E19-09-0548"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfCompartments>
<compartment id="c1" size="1" units="dimensionless" constant="true"/>
</listOfCompartments>
<listOfSpecies>
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</listOfSpecies>
<listOfParameters>
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<parameter id="numCells" name="numCells" value="10000000" units="dimensionless" constant="true"/>
<parameter id="volMedia" name="volMedia" value="0.01" units="dimensionless" constant="true"/>
<parameter id="Vextra" name="Vextra" value="1e-09" units="dimensionless" constant="true"/>
<parameter id="EGFR_total" name="EGFR_total" value="770000" units="dimensionless" constant="true"/>
<parameter id="EGFconc" name="EGFconc" value="2.5e-08" units="dimensionless" constant="true"/>
<parameter id="kon" name="kon" value="5000000" units="dimensionless" constant="true"/>
<parameter id="kon_EGF" name="kon_EGF" value="8000000" units="dimensionless" constant="true"/>
<parameter id="Kd_EGF" name="Kd_EGF" value="1204428" units="dimensionless" constant="true"/>
<parameter id="kp_EGF" name="kp_EGF" value="1.32843142138841e-08" units="dimensionless" constant="true"/>
<parameter id="km_EGF" name="km_EGF" value="0.016" units="dimensionless" constant="true"/>
<parameter id="KD_dim" name="KD_dim" value="38500" units="dimensionless" constant="true"/>
<parameter id="km_dim_L_L_pre" name="km_dim_L_L_pre" value="0.273" units="dimensionless" constant="true"/>
<parameter id="kp_dim_L_L_pre" name="kp_dim_L_L_pre" value="7.09090909090909e-06" units="dimensionless" constant="true"/>
<parameter id="offrate_f" name="offrate_f" value="1" units="dimensionless" constant="true"/>
<parameter id="onrate_f" name="onrate_f" value="1" units="dimensionless" constant="true"/>
<parameter id="km_dim_L_L" name="km_dim_L_L" value="0.273" units="dimensionless" constant="true"/>
<parameter id="kp_dim_L_L" name="kp_dim_L_L" value="7.09090909090909e-06" units="dimensionless" constant="true"/>
<parameter id="Kd_GE" name="Kd_GE" value="361328.4" units="dimensionless" constant="true"/>
<parameter id="kp_GE" name="kp_GE" value="8.30269638367756e-06" units="dimensionless" constant="true"/>
<parameter id="km_GE" name="km_GE" value="3" units="dimensionless" constant="true"/>
<parameter id="Kd_SE" name="Kd_SE" value="361328.4" units="dimensionless" constant="true"/>
<parameter id="kp_SE" name="kp_SE" value="8.30269638367756e-06" units="dimensionless" constant="true"/>
<parameter id="km_SE" name="km_SE" value="3" units="dimensionless" constant="true"/>
<parameter id="ratio_kphos_receiver" name="ratio_kphos_receiver" value="0.7" units="dimensionless" constant="true"/>
<parameter id="_rateLaw1" name="_rateLaw1" value="3.54545454545454e-06" units="dimensionless" constant="true"/>
<parameter id="EGF" name="EGF" value="0" units="dimensionless" constant="false"/>
<parameter id="EGFRtot" name="EGFRtot" value="0" units="dimensionless" constant="false"/>
<parameter id="Grb2tot" name="Grb2tot" value="0" units="dimensionless" constant="false"/>
<parameter id="Shc1tot" name="Shc1tot" value="0" units="dimensionless" constant="false"/>
<parameter id="pY1068" name="pY1068" value="0" units="dimensionless" constant="false"/>
<parameter id="pY1173" name="pY1173" value="0" units="dimensionless" constant="false"/>
<parameter id="unphosR" name="unphosR" value="0" units="dimensionless" constant="false"/>
</listOfParameters>
<listOfInitialAssignments>
<initialAssignment name="species_1" symbol="species_1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> EGFconc </ci>
<ci> NA </ci>
<ci> Vextra </ci>
</apply>
</math>
</initialAssignment>
<initialAssignment name="species_2" symbol="species_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> EGFR_total </ci>
</math>
</initialAssignment>
<initialAssignment name="species_3" symbol="species_3">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> GRB2_f </ci>
<ci> GRB2_total__FREE </ci>
<ci> f </ci>
</apply>
</math>
</initialAssignment>
<initialAssignment name="species_4" symbol="species_4">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> SHC1_total__FREE </ci>
<ci> f </ci>
</apply>
</math>
</initialAssignment>
</listOfInitialAssignments>
<listOfRules>
<assignmentRule name="EGF" variable="EGF">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> species_1 </ci>
<ci> species_5 </ci>
<ci> species_6 </ci>
<ci> species_7 </ci>
<ci> species_8 </ci>
<ci> species_9 </ci>
<ci> species_10 </ci>
<ci> species_11 </ci>
<ci> species_12 </ci>
<ci> species_13 </ci>
<ci> species_14 </ci>
<ci> species_15 </ci>
<ci> species_16 </ci>
<ci> species_17 </ci>
<ci> species_18 </ci>
<ci> species_19 </ci>
<ci> species_20 </ci>
<ci> species_21 </ci>
<ci> species_22 </ci>
<ci> species_23 </ci>
<ci> species_24 </ci>
<ci> species_25 </ci>
<ci> species_26 </ci>
<ci> species_30 </ci>
<ci> species_31 </ci>
<ci> species_32 </ci>
<ci> species_33 </ci>
<ci> species_34 </ci>
<ci> species_35 </ci>
<ci> species_36 </ci>
<ci> species_37 </ci>
<ci> species_38 </ci>
<ci> species_39 </ci>
<ci> species_40 </ci>
<ci> species_41 </ci>
<ci> species_42 </ci>
<ci> species_43 </ci>
<ci> species_44 </ci>
<ci> species_50 </ci>
<ci> species_51 </ci>
<ci> species_52 </ci>
<ci> species_53 </ci>
<ci> species_54 </ci>
<ci> species_55 </ci>
<ci> species_56 </ci>
<ci> species_57 </ci>
<ci> species_58 </ci>
<ci> species_59 </ci>
<ci> species_60 </ci>
<ci> species_66 </ci>
<ci> species_67 </ci>
<ci> species_68 </ci>
<ci> species_69 </ci>
<ci> species_70 </ci>
<ci> species_74 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule name="EGFRtot" variable="EGFRtot">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> species_2 </ci>
<ci> species_5 </ci>
<ci> species_6 </ci>
<ci> species_7 </ci>
<ci> species_8 </ci>
<ci> species_9 </ci>
<ci> species_10 </ci>
<ci> species_11 </ci>
<ci> species_12 </ci>
<ci> species_13 </ci>
<ci> species_14 </ci>
<ci> species_15 </ci>
<ci> species_16 </ci>
<ci> species_17 </ci>
<ci> species_18 </ci>
<ci> species_19 </ci>
<ci> species_20 </ci>
<ci> species_21 </ci>
<ci> species_22 </ci>
<ci> species_23 </ci>
<ci> species_24 </ci>
<ci> species_25 </ci>
<ci> species_26 </ci>
<ci> species_27 </ci>
<ci> species_28 </ci>
<ci> species_29 </ci>
<ci> species_30 </ci>
<ci> species_31 </ci>
<ci> species_32 </ci>
<ci> species_33 </ci>
<ci> species_34 </ci>
<ci> species_35 </ci>
<ci> species_36 </ci>
<ci> species_37 </ci>
<ci> species_38 </ci>
<ci> species_39 </ci>
<ci> species_40 </ci>
<ci> species_41 </ci>
<ci> species_42 </ci>
<ci> species_43 </ci>
<ci> species_44 </ci>
<ci> species_45 </ci>
<ci> species_46 </ci>
<ci> species_47 </ci>
<ci> species_48 </ci>
<ci> species_49 </ci>
<ci> species_50 </ci>
<ci> species_51 </ci>
<ci> species_52 </ci>
<ci> species_53 </ci>
<ci> species_54 </ci>
<ci> species_55 </ci>
<ci> species_56 </ci>
<ci> species_57 </ci>
<ci> species_58 </ci>
<ci> species_59 </ci>
<ci> species_60 </ci>
<ci> species_61 </ci>
<ci> species_62 </ci>
<ci> species_63 </ci>
<ci> species_64 </ci>
<ci> species_65 </ci>
<ci> species_66 </ci>
<ci> species_67 </ci>
<ci> species_68 </ci>
<ci> species_69 </ci>
<ci> species_70 </ci>
<ci> species_71 </ci>
<ci> species_72 </ci>
<ci> species_73 </ci>
<ci> species_74 </ci>
<ci> species_75 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule name="Grb2tot" variable="Grb2tot">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> species_3 </ci>
<ci> species_23 </ci>
<ci> species_24 </ci>
<ci> species_33 </ci>
<ci> species_37 </ci>
<ci> species_38 </ci>
<ci> species_42 </ci>
<ci> species_43 </ci>
<ci> species_48 </ci>
<ci> species_52 </ci>
<ci> species_53 </ci>
<ci> species_56 </ci>
<ci> species_58 </ci>
<ci> species_59 </ci>
<ci> species_60 </ci>
<ci> species_63 </ci>
<ci> species_64 </ci>
<ci> species_67 </ci>
<ci> species_68 </ci>
<ci> species_69 </ci>
<ci> species_70 </ci>
<ci> species_72 </ci>
<ci> species_73 </ci>
<ci> species_74 </ci>
<ci> species_75 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule name="Shc1tot" variable="Shc1tot">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> species_4 </ci>
<ci> species_25 </ci>
<ci> species_26 </ci>
<ci> species_34 </ci>
<ci> species_36 </ci>
<ci> species_39 </ci>
<ci> species_41 </ci>
<ci> species_44 </ci>
<ci> species_49 </ci>
<ci> species_51 </ci>
<ci> species_54 </ci>
<ci> species_55 </ci>
<ci> species_57 </ci>
<ci> species_59 </ci>
<ci> species_60 </ci>
<ci> species_62 </ci>
<ci> species_65 </ci>
<ci> species_66 </ci>
<ci> species_68 </ci>
<ci> species_69 </ci>
<ci> species_70 </ci>
<ci> species_71 </ci>
<ci> species_73 </ci>
<ci> species_74 </ci>
<ci> species_75 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule name="pY1068" variable="pY1068">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> species_8 </ci>
<ci> species_11 </ci>
<ci> species_14 </ci>
<ci> species_17 </ci>
<ci> species_18 </ci>
<ci> species_20 </ci>
<ci> species_21 </ci>
<ci> species_23 </ci>
<ci> species_24 </ci>
<ci> species_27 </ci>
<ci> species_30 </ci>
<ci> species_31 </ci>
<ci> species_33 </ci>
<ci> species_35 </ci>
<ci> species_36 </ci>
<ci> species_37 </ci>
<ci> species_38 </ci>
<ci> species_40 </ci>
<ci> species_41 </ci>
<ci> species_42 </ci>
<ci> species_43 </ci>
<ci> species_45 </ci>
<ci> species_46 </ci>
<ci> species_48 </ci>
<ci> species_50 </ci>
<ci> species_51 </ci>
<ci> species_52 </ci>
<ci> species_53 </ci>
<ci> species_55 </ci>
<ci> species_56 </ci>
<ci> species_57 </ci>
<ci> species_58 </ci>
<ci> species_59 </ci>
<ci> species_60 </ci>
<ci> species_61 </ci>
<ci> species_62 </ci>
<ci> species_63 </ci>
<ci> species_64 </ci>
<ci> species_66 </ci>
<ci> species_67 </ci>
<ci> species_68 </ci>
<ci> species_69 </ci>
<ci> species_70 </ci>
<ci> species_71 </ci>
<ci> species_72 </ci>
<ci> species_73 </ci>
<ci> species_74 </ci>
<ci> species_75 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule name="pY1173" variable="pY1173">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> species_9 </ci>
<ci> species_12 </ci>
<ci> species_15 </ci>
<ci> species_17 </ci>
<ci> species_19 </ci>
<ci> species_20 </ci>
<ci> species_22 </ci>
<ci> species_25 </ci>
<ci> species_26 </ci>
<ci> species_28 </ci>
<ci> species_30 </ci>
<ci> species_32 </ci>
<ci> species_34 </ci>
<ci> species_35 </ci>
<ci> species_36 </ci>
<ci> species_37 </ci>
<ci> species_39 </ci>
<ci> species_40 </ci>
<ci> species_41 </ci>
<ci> species_42 </ci>
<ci> species_44 </ci>
<ci> species_45 </ci>
<ci> species_47 </ci>
<ci> species_49 </ci>
<ci> species_50 </ci>
<ci> species_51 </ci>
<ci> species_52 </ci>
<ci> species_54 </ci>
<ci> species_55 </ci>
<ci> species_56 </ci>
<ci> species_57 </ci>
<ci> species_58 </ci>
<ci> species_59 </ci>
<ci> species_60 </ci>
<ci> species_61 </ci>
<ci> species_62 </ci>
<ci> species_63 </ci>
<ci> species_65 </ci>
<ci> species_66 </ci>
<ci> species_67 </ci>
<ci> species_68 </ci>
<ci> species_69 </ci>
<ci> species_70 </ci>
<ci> species_71 </ci>
<ci> species_72 </ci>
<ci> species_73 </ci>
<ci> species_74 </ci>
<ci> species_75 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule name="unphosR" variable="unphosR">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> species_2 </ci>
<ci> species_5 </ci>
<ci> species_6 </ci>
<ci> species_7 </ci>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction id="reaction_1" reversible="false">
<listOfReactants>
<speciesReference species="species_1" stoichiometry="1" constant="true"/>
<speciesReference species="species_2" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_5" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kp_EGF </ci>
<ci> species_1 </ci>
<ci> species_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_2" reversible="false">
<listOfReactants>
<speciesReference species="species_5" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_1" stoichiometry="1" constant="true"/>
<speciesReference species="species_2" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_EGF </ci>
<ci> species_5 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_3" reversible="false">
<listOfReactants>
<speciesReference species="species_5" stoichiometry="1" constant="true"/>
<speciesReference species="species_5" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_6" stoichiometry="1" constant="true"/>
<speciesReference species="species_7" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> _rateLaw1 </ci>
<ci> species_5 </ci>
<ci> species_5 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_4" reversible="false">
<listOfReactants>
<speciesReference species="species_6" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_5" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_dim_L_L </ci>
<ci> species_6 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_5" reversible="false">
<listOfReactants>
<speciesReference species="species_7" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_5" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_dim_L_L </ci>
<ci> species_7 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_6" reversible="false">
<listOfReactants>
<speciesReference species="species_6" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_8" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_6 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_7" reversible="false">
<listOfReactants>
<speciesReference species="species_6" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_9" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphosY1173 </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_6 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_8" reversible="false">
<listOfReactants>
<speciesReference species="species_6" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_10" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosYN__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kpkd_YN__FREE </ci>
<ci> species_6 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_9" reversible="false">
<listOfReactants>
<speciesReference species="species_7" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_11" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphos_receiver </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_7 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_10" reversible="false">
<listOfReactants>
<speciesReference species="species_7" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_12" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphosY1173 </ci>
<ci> ratio_kphos_receiver </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_7 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_11" reversible="false">
<listOfReactants>
<speciesReference species="species_7" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_13" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosYN__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphos_receiver </ci>
<ci> ratio_kpkd_YN__FREE </ci>
<ci> species_7 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_12" reversible="false">
<listOfReactants>
<speciesReference species="species_8" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_14" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_dim_L_L </ci>
<ci> species_8 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_13" reversible="false">
<listOfReactants>
<speciesReference species="species_9" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_15" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_dim_L_L </ci>
<ci> species_9 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_14" reversible="false">
<listOfReactants>
<speciesReference species="species_10" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_16" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_dim_L_L </ci>
<ci> species_10 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_15" reversible="false">
<listOfReactants>
<speciesReference species="species_11" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_14" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_dim_L_L </ci>
<ci> species_11 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_16" reversible="false">
<listOfReactants>
<speciesReference species="species_12" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_15" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_dim_L_L </ci>
<ci> species_12 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_17" reversible="false">
<listOfReactants>
<speciesReference species="species_13" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_16" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> km_dim_L_L </ci>
<ci> species_13 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_18" reversible="false">
<listOfReactants>
<speciesReference species="species_9" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_17" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_9 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_19" reversible="false">
<listOfReactants>
<speciesReference species="species_10" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_18" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_10 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_20" reversible="false">
<listOfReactants>
<speciesReference species="species_8" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_17" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphosY1173 </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_8 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_21" reversible="false">
<listOfReactants>
<speciesReference species="species_10" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_19" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphosY1173 </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_10 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_22" reversible="false">
<listOfReactants>
<speciesReference species="species_8" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_18" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosYN__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kpkd_YN__FREE </ci>
<ci> species_8 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_23" reversible="false">
<listOfReactants>
<speciesReference species="species_9" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_19" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosYN__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kpkd_YN__FREE </ci>
<ci> species_9 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_24" reversible="false">
<listOfReactants>
<speciesReference species="species_12" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_20" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphos_receiver </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_12 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_25" reversible="false">
<listOfReactants>
<speciesReference species="species_13" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_21" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphos_receiver </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_13 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_26" reversible="false">
<listOfReactants>
<speciesReference species="species_11" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="species_20" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdephosY1068__FREE </ci>
<ci> kphos_f </ci>
<ci> ratio_kphosY1173 </ci>
<ci> ratio_kphos_receiver </ci>
<ci> ratio_kpkd_Y1068__FREE </ci>
<ci> species_11 </ci>
</apply>
</math>
</kineticLaw>
</reaction>