DESCRIPTION

Package: decider
Title: Decision making in multiple-arm oncology dose escalation trials with logistic regression
Version: 0.0.0.9012
Authors@R: 
    c(person(given = "Lukas",
           family = "Schroeter",
           role = c("aut", "cre"),
           email = "lukas.schroeter@boehringer-ingelheim.com")
      ,person(given = "Daniela",
           family = "Maier",
           role = c("ctb"),
           email = "daniela_2.maier@boehringer-ingelheim.com")
      ,person(given = "Boehringer Ingelheim",
           family = "Pharma GmbH & Co. KG",
           role = c("cph", "fnd")))
Description: Provides functions that allow to compute posterior distributions of 
  Bayesian logistic regression models (BLRMs) for monotherapy and combination 
  therapy dose-finding trials with one or more arms, summarizing them via dosing 
  intervals, and simulating such trial designs. Data scenarios can be evaluated 
  and trial simulations can be conducted for multiple variants of the BLRM. Functions are provided to aid
  designing BLRM-based dose finding for concurrent monotherapy and combination 
  therapy trials following (Neuenschwander et al. (2008) <doi:10.1002/sim.3230>),
  (Neuenschwander et al. (2014) <doi:10.1201/b17965>). The main implemented model is
  the hierarchical BLRM for monotherapy and combination therapy (Neuenschwander et al. (2016) 
  <doi:10.1080/19466315.2016.1174149>), and a variant with an additional binary 
  covariate. All Bayesian models are evaluated using the 'Stan' modeling language 
  via the package 'rstan', refer to Stan Development Team (2020) <https://mc-stan.org>.
License: Apache License (>= 2)
Encoding: UTF-8
LazyData: true
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.1.2
Biarch: true
Depends: 
    R (>= 3.4.0)
Imports: 
    methods,
    stats,
    grDevices,
    parallel,
    foreach,
    doParallel,
    openxlsx,
    gridExtra,
    scales,
    ggplot2,
    openssl,
    flock,
    doRNG,
    Rcpp (>= 0.12.0),
    RcppParallel (>= 5.0.1),
    rstan (>= 2.18.1),
    rstantools (>= 2.1.1),
    lifecycle
LinkingTo: 
    BH (>= 1.66.0),
    Rcpp (>= 0.12.0),
    RcppEigen (>= 0.3.3.3.0),
    RcppParallel (>= 5.0.1),
    rstan (>= 2.18.1),
    StanHeaders (>= 2.18.0)
SystemRequirements: GNU make
Suggests: 
    rmarkdown,
    knitr,
    testthat (>= 3.0.0)
VignetteBuilder: knitr
Config/testthat/edition: 3
URL: https://Boehringer-Ingelheim.github.io/decider/