LD Score Regression to estimate the genetic correlation between a pair of traits.
Aim: Estimate the genetic correlation (r²) between epilepsy traits versus other traits (i.e., metabolites/biomarkers, habitual sleep duration, circadian-related)
Example script: refer to LDSC_script_Shortsleep_vs_Epilepsy.sh

Analysis Overview:
-- Step 1: Format and Clean the raw GWAS Sumstats with munge_sumstats.py
-- Step 2: Cross-trait LD score regression with ldsc.py

Visualization
-- Using ggcorplot - refer to LDSC_graph_making.R

Useful sources

LDSC GitHub: https://github.com/bulik/ldsc
Useful tutorial: https://cloufield.github.io/GWASTutorial/08_LDSC/