POPSIZE_Script_Simulation_exempleFR.html

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}
.glyphicon-triangle-bottom:before {
  content: "\e252";
}
.glyphicon-triangle-top:before {
  content: "\e253";
}
.glyphicon-console:before {
  content: "\e254";
}
.glyphicon-superscript:before {
  content: "\e255";
}
.glyphicon-subscript:before {
  content: "\e256";
}
.glyphicon-menu-left:before {
  content: "\e257";
}
.glyphicon-menu-right:before {
  content: "\e258";
}
.glyphicon-menu-down:before {
  content: "\e259";
}
.glyphicon-menu-up:before {
  content: "\e260";
}
* {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
*:before,
*:after {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
html {
  font-size: 10px;
  -webkit-tap-highlight-color: rgba(0, 0, 0, 0);
}
body {
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-size: 13px;
  line-height: 1.42857143;
  color: #000;
  background-color: #fff;
}
input,
button,
select,
textarea {
  font-family: inherit;
  font-size: inherit;
  line-height: inherit;
}
a {
  color: #337ab7;
  text-decoration: none;
}
a:hover,
a:focus {
  color: #23527c;
  text-decoration: underline;
}
a:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
figure {
  margin: 0;
}
img {
  vertical-align: middle;
}
.img-responsive,
.thumbnail > img,
.thumbnail a > img,
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  display: block;
  max-width: 100%;
  height: auto;
}
.img-rounded {
  border-radius: 3px;
}
.img-thumbnail {
  padding: 4px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: all 0.2s ease-in-out;
  -o-transition: all 0.2s ease-in-out;
  transition: all 0.2s ease-in-out;
  display: inline-block;
  max-width: 100%;
  height: auto;
}
.img-circle {
  border-radius: 50%;
}
hr {
  margin-top: 18px;
  margin-bottom: 18px;
  border: 0;
  border-top: 1px solid #eeeeee;
}
.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  margin: -1px;
  padding: 0;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  border: 0;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
[role="button"] {
  cursor: pointer;
}
h1,
h2,
h3,
h4,
h5,
h6,
.h1,
.h2,
.h3,
.h4,
.h5,
.h6 {
  font-family: inherit;
  font-weight: 500;
  line-height: 1.1;
  color: inherit;
}
h1 small,
h2 small,
h3 small,
h4 small,
h5 small,
h6 small,
.h1 small,
.h2 small,
.h3 small,
.h4 small,
.h5 small,
.h6 small,
h1 .small,
h2 .small,
h3 .small,
h4 .small,
h5 .small,
h6 .small,
.h1 .small,
.h2 .small,
.h3 .small,
.h4 .small,
.h5 .small,
.h6 .small {
  font-weight: normal;
  line-height: 1;
  color: #777777;
}
h1,
.h1,
h2,
.h2,
h3,
.h3 {
  margin-top: 18px;
  margin-bottom: 9px;
}
h1 small,
.h1 small,
h2 small,
.h2 small,
h3 small,
.h3 small,
h1 .small,
.h1 .small,
h2 .small,
.h2 .small,
h3 .small,
.h3 .small {
  font-size: 65%;
}
h4,
.h4,
h5,
.h5,
h6,
.h6 {
  margin-top: 9px;
  margin-bottom: 9px;
}
h4 small,
.h4 small,
h5 small,
.h5 small,
h6 small,
.h6 small,
h4 .small,
.h4 .small,
h5 .small,
.h5 .small,
h6 .small,
.h6 .small {
  font-size: 75%;
}
h1,
.h1 {
  font-size: 33px;
}
h2,
.h2 {
  font-size: 27px;
}
h3,
.h3 {
  font-size: 23px;
}
h4,
.h4 {
  font-size: 17px;
}
h5,
.h5 {
  font-size: 13px;
}
h6,
.h6 {
  font-size: 12px;
}
p {
  margin: 0 0 9px;
}
.lead {
  margin-bottom: 18px;
  font-size: 14px;
  font-weight: 300;
  line-height: 1.4;
}
@media (min-width: 768px) {
  .lead {
    font-size: 19.5px;
  }
}
small,
.small {
  font-size: 92%;
}
mark,
.mark {
  background-color: #fcf8e3;
  padding: .2em;
}
.text-left {
  text-align: left;
}
.text-right {
  text-align: right;
}
.text-center {
  text-align: center;
}
.text-justify {
  text-align: justify;
}
.text-nowrap {
  white-space: nowrap;
}
.text-lowercase {
  text-transform: lowercase;
}
.text-uppercase {
  text-transform: uppercase;
}
.text-capitalize {
  text-transform: capitalize;
}
.text-muted {
  color: #777777;
}
.text-primary {
  color: #337ab7;
}
a.text-primary:hover,
a.text-primary:focus {
  color: #286090;
}
.text-success {
  color: #3c763d;
}
a.text-success:hover,
a.text-success:focus {
  color: #2b542c;
}
.text-info {
  color: #31708f;
}
a.text-info:hover,
a.text-info:focus {
  color: #245269;
}
.text-warning {
  color: #8a6d3b;
}
a.text-warning:hover,
a.text-warning:focus {
  color: #66512c;
}
.text-danger {
  color: #a94442;
}
a.text-danger:hover,
a.text-danger:focus {
  color: #843534;
}
.bg-primary {
  color: #fff;
  background-color: #337ab7;
}
a.bg-primary:hover,
a.bg-primary:focus {
  background-color: #286090;
}
.bg-success {
  background-color: #dff0d8;
}
a.bg-success:hover,
a.bg-success:focus {
  background-color: #c1e2b3;
}
.bg-info {
  background-color: #d9edf7;
}
a.bg-info:hover,
a.bg-info:focus {
  background-color: #afd9ee;
}
.bg-warning {
  background-color: #fcf8e3;
}
a.bg-warning:hover,
a.bg-warning:focus {
  background-color: #f7ecb5;
}
.bg-danger {
  background-color: #f2dede;
}
a.bg-danger:hover,
a.bg-danger:focus {
  background-color: #e4b9b9;
}
.page-header {
  padding-bottom: 8px;
  margin: 36px 0 18px;
  border-bottom: 1px solid #eeeeee;
}
ul,
ol {
  margin-top: 0;
  margin-bottom: 9px;
}
ul ul,
ol ul,
ul ol,
ol ol {
  margin-bottom: 0;
}
.list-unstyled {
  padding-left: 0;
  list-style: none;
}
.list-inline {
  padding-left: 0;
  list-style: none;
  margin-left: -5px;
}
.list-inline > li {
  display: inline-block;
  padding-left: 5px;
  padding-right: 5px;
}
dl {
  margin-top: 0;
  margin-bottom: 18px;
}
dt,
dd {
  line-height: 1.42857143;
}
dt {
  font-weight: bold;
}
dd {
  margin-left: 0;
}
@media (min-width: 541px) {
  .dl-horizontal dt {
    float: left;
    width: 160px;
    clear: left;
    text-align: right;
    overflow: hidden;
    text-overflow: ellipsis;
    white-space: nowrap;
  }
  .dl-horizontal dd {
    margin-left: 180px;
  }
}
abbr[title],
abbr[data-original-title] {
  cursor: help;
  border-bottom: 1px dotted #777777;
}
.initialism {
  font-size: 90%;
  text-transform: uppercase;
}
blockquote {
  padding: 9px 18px;
  margin: 0 0 18px;
  font-size: inherit;
  border-left: 5px solid #eeeeee;
}
blockquote p:last-child,
blockquote ul:last-child,
blockquote ol:last-child {
  margin-bottom: 0;
}
blockquote footer,
blockquote small,
blockquote .small {
  display: block;
  font-size: 80%;
  line-height: 1.42857143;
  color: #777777;
}
blockquote footer:before,
blockquote small:before,
blockquote .small:before {
  content: '\2014 \00A0';
}
.blockquote-reverse,
blockquote.pull-right {
  padding-right: 15px;
  padding-left: 0;
  border-right: 5px solid #eeeeee;
  border-left: 0;
  text-align: right;
}
.blockquote-reverse footer:before,
blockquote.pull-right footer:before,
.blockquote-reverse small:before,
blockquote.pull-right small:before,
.blockquote-reverse .small:before,
blockquote.pull-right .small:before {
  content: '';
}
.blockquote-reverse footer:after,
blockquote.pull-right footer:after,
.blockquote-reverse small:after,
blockquote.pull-right small:after,
.blockquote-reverse .small:after,
blockquote.pull-right .small:after {
  content: '\00A0 \2014';
}
address {
  margin-bottom: 18px;
  font-style: normal;
  line-height: 1.42857143;
}
code,
kbd,
pre,
samp {
  font-family: monospace;
}
code {
  padding: 2px 4px;
  font-size: 90%;
  color: #c7254e;
  background-color: #f9f2f4;
  border-radius: 2px;
}
kbd {
  padding: 2px 4px;
  font-size: 90%;
  color: #888;
  background-color: transparent;
  border-radius: 1px;
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.25);
}
kbd kbd {
  padding: 0;
  font-size: 100%;
  font-weight: bold;
  box-shadow: none;
}
pre {
  display: block;
  padding: 8.5px;
  margin: 0 0 9px;
  font-size: 12px;
  line-height: 1.42857143;
  word-break: break-all;
  word-wrap: break-word;
  color: #333333;
  background-color: #f5f5f5;
  border: 1px solid #ccc;
  border-radius: 2px;
}
pre code {
  padding: 0;
  font-size: inherit;
  color: inherit;
  white-space: pre-wrap;
  background-color: transparent;
  border-radius: 0;
}
.pre-scrollable {
  max-height: 340px;
  overflow-y: scroll;
}
.container {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
@media (min-width: 768px) {
  .container {
    width: 768px;
  }
}
@media (min-width: 992px) {
  .container {
    width: 940px;
  }
}
@media (min-width: 1200px) {
  .container {
    width: 1140px;
  }
}
.container-fluid {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
.row {
  margin-left: 0px;
  margin-right: 0px;
}
.col-xs-1, .col-sm-1, .col-md-1, .col-lg-1, .col-xs-2, .col-sm-2, .col-md-2, .col-lg-2, .col-xs-3, .col-sm-3, .col-md-3, .col-lg-3, .col-xs-4, .col-sm-4, .col-md-4, .col-lg-4, .col-xs-5, .col-sm-5, .col-md-5, .col-lg-5, .col-xs-6, .col-sm-6, .col-md-6, .col-lg-6, .col-xs-7, .col-sm-7, .col-md-7, .col-lg-7, .col-xs-8, .col-sm-8, .col-md-8, .col-lg-8, .col-xs-9, .col-sm-9, .col-md-9, .col-lg-9, .col-xs-10, .col-sm-10, .col-md-10, .col-lg-10, .col-xs-11, .col-sm-11, .col-md-11, .col-lg-11, .col-xs-12, .col-sm-12, .col-md-12, .col-lg-12 {
  position: relative;
  min-height: 1px;
  padding-left: 0px;
  padding-right: 0px;
}
.col-xs-1, .col-xs-2, .col-xs-3, .col-xs-4, .col-xs-5, .col-xs-6, .col-xs-7, .col-xs-8, .col-xs-9, .col-xs-10, .col-xs-11, .col-xs-12 {
  float: left;
}
.col-xs-12 {
  width: 100%;
}
.col-xs-11 {
  width: 91.66666667%;
}
.col-xs-10 {
  width: 83.33333333%;
}
.col-xs-9 {
  width: 75%;
}
.col-xs-8 {
  width: 66.66666667%;
}
.col-xs-7 {
  width: 58.33333333%;
}
.col-xs-6 {
  width: 50%;
}
.col-xs-5 {
  width: 41.66666667%;
}
.col-xs-4 {
  width: 33.33333333%;
}
.col-xs-3 {
  width: 25%;
}
.col-xs-2 {
  width: 16.66666667%;
}
.col-xs-1 {
  width: 8.33333333%;
}
.col-xs-pull-12 {
  right: 100%;
}
.col-xs-pull-11 {
  right: 91.66666667%;
}
.col-xs-pull-10 {
  right: 83.33333333%;
}
.col-xs-pull-9 {
  right: 75%;
}
.col-xs-pull-8 {
  right: 66.66666667%;
}
.col-xs-pull-7 {
  right: 58.33333333%;
}
.col-xs-pull-6 {
  right: 50%;
}
.col-xs-pull-5 {
  right: 41.66666667%;
}
.col-xs-pull-4 {
  right: 33.33333333%;
}
.col-xs-pull-3 {
  right: 25%;
}
.col-xs-pull-2 {
  right: 16.66666667%;
}
.col-xs-pull-1 {
  right: 8.33333333%;
}
.col-xs-pull-0 {
  right: auto;
}
.col-xs-push-12 {
  left: 100%;
}
.col-xs-push-11 {
  left: 91.66666667%;
}
.col-xs-push-10 {
  left: 83.33333333%;
}
.col-xs-push-9 {
  left: 75%;
}
.col-xs-push-8 {
  left: 66.66666667%;
}
.col-xs-push-7 {
  left: 58.33333333%;
}
.col-xs-push-6 {
  left: 50%;
}
.col-xs-push-5 {
  left: 41.66666667%;
}
.col-xs-push-4 {
  left: 33.33333333%;
}
.col-xs-push-3 {
  left: 25%;
}
.col-xs-push-2 {
  left: 16.66666667%;
}
.col-xs-push-1 {
  left: 8.33333333%;
}
.col-xs-push-0 {
  left: auto;
}
.col-xs-offset-12 {
  margin-left: 100%;
}
.col-xs-offset-11 {
  margin-left: 91.66666667%;
}
.col-xs-offset-10 {
  margin-left: 83.33333333%;
}
.col-xs-offset-9 {
  margin-left: 75%;
}
.col-xs-offset-8 {
  margin-left: 66.66666667%;
}
.col-xs-offset-7 {
  margin-left: 58.33333333%;
}
.col-xs-offset-6 {
  margin-left: 50%;
}
.col-xs-offset-5 {
  margin-left: 41.66666667%;
}
.col-xs-offset-4 {
  margin-left: 33.33333333%;
}
.col-xs-offset-3 {
  margin-left: 25%;
}
.col-xs-offset-2 {
  margin-left: 16.66666667%;
}
.col-xs-offset-1 {
  margin-left: 8.33333333%;
}
.col-xs-offset-0 {
  margin-left: 0%;
}
@media (min-width: 768px) {
  .col-sm-1, .col-sm-2, .col-sm-3, .col-sm-4, .col-sm-5, .col-sm-6, .col-sm-7, .col-sm-8, .col-sm-9, .col-sm-10, .col-sm-11, .col-sm-12 {
    float: left;
  }
  .col-sm-12 {
    width: 100%;
  }
  .col-sm-11 {
    width: 91.66666667%;
  }
  .col-sm-10 {
    width: 83.33333333%;
  }
  .col-sm-9 {
    width: 75%;
  }
  .col-sm-8 {
    width: 66.66666667%;
  }
  .col-sm-7 {
    width: 58.33333333%;
  }
  .col-sm-6 {
    width: 50%;
  }
  .col-sm-5 {
    width: 41.66666667%;
  }
  .col-sm-4 {
    width: 33.33333333%;
  }
  .col-sm-3 {
    width: 25%;
  }
  .col-sm-2 {
    width: 16.66666667%;
  }
  .col-sm-1 {
    width: 8.33333333%;
  }
  .col-sm-pull-12 {
    right: 100%;
  }
  .col-sm-pull-11 {
    right: 91.66666667%;
  }
  .col-sm-pull-10 {
    right: 83.33333333%;
  }
  .col-sm-pull-9 {
    right: 75%;
  }
  .col-sm-pull-8 {
    right: 66.66666667%;
  }
  .col-sm-pull-7 {
    right: 58.33333333%;
  }
  .col-sm-pull-6 {
    right: 50%;
  }
  .col-sm-pull-5 {
    right: 41.66666667%;
  }
  .col-sm-pull-4 {
    right: 33.33333333%;
  }
  .col-sm-pull-3 {
    right: 25%;
  }
  .col-sm-pull-2 {
    right: 16.66666667%;
  }
  .col-sm-pull-1 {
    right: 8.33333333%;
  }
  .col-sm-pull-0 {
    right: auto;
  }
  .col-sm-push-12 {
    left: 100%;
  }
  .col-sm-push-11 {
    left: 91.66666667%;
  }
  .col-sm-push-10 {
    left: 83.33333333%;
  }
  .col-sm-push-9 {
    left: 75%;
  }
  .col-sm-push-8 {
    left: 66.66666667%;
  }
  .col-sm-push-7 {
    left: 58.33333333%;
  }
  .col-sm-push-6 {
    left: 50%;
  }
  .col-sm-push-5 {
    left: 41.66666667%;
  }
  .col-sm-push-4 {
    left: 33.33333333%;
  }
  .col-sm-push-3 {
    left: 25%;
  }
  .col-sm-push-2 {
    left: 16.66666667%;
  }
  .col-sm-push-1 {
    left: 8.33333333%;
  }
  .col-sm-push-0 {
    left: auto;
  }
  .col-sm-offset-12 {
    margin-left: 100%;
  }
  .col-sm-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-sm-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-sm-offset-9 {
    margin-left: 75%;
  }
  .col-sm-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-sm-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-sm-offset-6 {
    margin-left: 50%;
  }
  .col-sm-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-sm-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-sm-offset-3 {
    margin-left: 25%;
  }
  .col-sm-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-sm-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-sm-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 992px) {
  .col-md-1, .col-md-2, .col-md-3, .col-md-4, .col-md-5, .col-md-6, .col-md-7, .col-md-8, .col-md-9, .col-md-10, .col-md-11, .col-md-12 {
    float: left;
  }
  .col-md-12 {
    width: 100%;
  }
  .col-md-11 {
    width: 91.66666667%;
  }
  .col-md-10 {
    width: 83.33333333%;
  }
  .col-md-9 {
    width: 75%;
  }
  .col-md-8 {
    width: 66.66666667%;
  }
  .col-md-7 {
    width: 58.33333333%;
  }
  .col-md-6 {
    width: 50%;
  }
  .col-md-5 {
    width: 41.66666667%;
  }
  .col-md-4 {
    width: 33.33333333%;
  }
  .col-md-3 {
    width: 25%;
  }
  .col-md-2 {
    width: 16.66666667%;
  }
  .col-md-1 {
    width: 8.33333333%;
  }
  .col-md-pull-12 {
    right: 100%;
  }
  .col-md-pull-11 {
    right: 91.66666667%;
  }
  .col-md-pull-10 {
    right: 83.33333333%;
  }
  .col-md-pull-9 {
    right: 75%;
  }
  .col-md-pull-8 {
    right: 66.66666667%;
  }
  .col-md-pull-7 {
    right: 58.33333333%;
  }
  .col-md-pull-6 {
    right: 50%;
  }
  .col-md-pull-5 {
    right: 41.66666667%;
  }
  .col-md-pull-4 {
    right: 33.33333333%;
  }
  .col-md-pull-3 {
    right: 25%;
  }
  .col-md-pull-2 {
    right: 16.66666667%;
  }
  .col-md-pull-1 {
    right: 8.33333333%;
  }
  .col-md-pull-0 {
    right: auto;
  }
  .col-md-push-12 {
    left: 100%;
  }
  .col-md-push-11 {
    left: 91.66666667%;
  }
  .col-md-push-10 {
    left: 83.33333333%;
  }
  .col-md-push-9 {
    left: 75%;
  }
  .col-md-push-8 {
    left: 66.66666667%;
  }
  .col-md-push-7 {
    left: 58.33333333%;
  }
  .col-md-push-6 {
    left: 50%;
  }
  .col-md-push-5 {
    left: 41.66666667%;
  }
  .col-md-push-4 {
    left: 33.33333333%;
  }
  .col-md-push-3 {
    left: 25%;
  }
  .col-md-push-2 {
    left: 16.66666667%;
  }
  .col-md-push-1 {
    left: 8.33333333%;
  }
  .col-md-push-0 {
    left: auto;
  }
  .col-md-offset-12 {
    margin-left: 100%;
  }
  .col-md-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-md-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-md-offset-9 {
    margin-left: 75%;
  }
  .col-md-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-md-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-md-offset-6 {
    margin-left: 50%;
  }
  .col-md-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-md-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-md-offset-3 {
    margin-left: 25%;
  }
  .col-md-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-md-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-md-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 1200px) {
  .col-lg-1, .col-lg-2, .col-lg-3, .col-lg-4, .col-lg-5, .col-lg-6, .col-lg-7, .col-lg-8, .col-lg-9, .col-lg-10, .col-lg-11, .col-lg-12 {
    float: left;
  }
  .col-lg-12 {
    width: 100%;
  }
  .col-lg-11 {
    width: 91.66666667%;
  }
  .col-lg-10 {
    width: 83.33333333%;
  }
  .col-lg-9 {
    width: 75%;
  }
  .col-lg-8 {
    width: 66.66666667%;
  }
  .col-lg-7 {
    width: 58.33333333%;
  }
  .col-lg-6 {
    width: 50%;
  }
  .col-lg-5 {
    width: 41.66666667%;
  }
  .col-lg-4 {
    width: 33.33333333%;
  }
  .col-lg-3 {
    width: 25%;
  }
  .col-lg-2 {
    width: 16.66666667%;
  }
  .col-lg-1 {
    width: 8.33333333%;
  }
  .col-lg-pull-12 {
    right: 100%;
  }
  .col-lg-pull-11 {
    right: 91.66666667%;
  }
  .col-lg-pull-10 {
    right: 83.33333333%;
  }
  .col-lg-pull-9 {
    right: 75%;
  }
  .col-lg-pull-8 {
    right: 66.66666667%;
  }
  .col-lg-pull-7 {
    right: 58.33333333%;
  }
  .col-lg-pull-6 {
    right: 50%;
  }
  .col-lg-pull-5 {
    right: 41.66666667%;
  }
  .col-lg-pull-4 {
    right: 33.33333333%;
  }
  .col-lg-pull-3 {
    right: 25%;
  }
  .col-lg-pull-2 {
    right: 16.66666667%;
  }
  .col-lg-pull-1 {
    right: 8.33333333%;
  }
  .col-lg-pull-0 {
    right: auto;
  }
  .col-lg-push-12 {
    left: 100%;
  }
  .col-lg-push-11 {
    left: 91.66666667%;
  }
  .col-lg-push-10 {
    left: 83.33333333%;
  }
  .col-lg-push-9 {
    left: 75%;
  }
  .col-lg-push-8 {
    left: 66.66666667%;
  }
  .col-lg-push-7 {
    left: 58.33333333%;
  }
  .col-lg-push-6 {
    left: 50%;
  }
  .col-lg-push-5 {
    left: 41.66666667%;
  }
  .col-lg-push-4 {
    left: 33.33333333%;
  }
  .col-lg-push-3 {
    left: 25%;
  }
  .col-lg-push-2 {
    left: 16.66666667%;
  }
  .col-lg-push-1 {
    left: 8.33333333%;
  }
  .col-lg-push-0 {
    left: auto;
  }
  .col-lg-offset-12 {
    margin-left: 100%;
  }
  .col-lg-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-lg-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-lg-offset-9 {
    margin-left: 75%;
  }
  .col-lg-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-lg-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-lg-offset-6 {
    margin-left: 50%;
  }
  .col-lg-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-lg-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-lg-offset-3 {
    margin-left: 25%;
  }
  .col-lg-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-lg-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-lg-offset-0 {
    margin-left: 0%;
  }
}
table {
  background-color: transparent;
}
caption {
  padding-top: 8px;
  padding-bottom: 8px;
  color: #777777;
  text-align: left;
}
th {
  text-align: left;
}
.table {
  width: 100%;
  max-width: 100%;
  margin-bottom: 18px;
}
.table > thead > tr > th,
.table > tbody > tr > th,
.table > tfoot > tr > th,
.table > thead > tr > td,
.table > tbody > tr > td,
.table > tfoot > tr > td {
  padding: 8px;
  line-height: 1.42857143;
  vertical-align: top;
  border-top: 1px solid #ddd;
}
.table > thead > tr > th {
  vertical-align: bottom;
  border-bottom: 2px solid #ddd;
}
.table > caption + thead > tr:first-child > th,
.table > colgroup + thead > tr:first-child > th,
.table > thead:first-child > tr:first-child > th,
.table > caption + thead > tr:first-child > td,
.table > colgroup + thead > tr:first-child > td,
.table > thead:first-child > tr:first-child > td {
  border-top: 0;
}
.table > tbody + tbody {
  border-top: 2px solid #ddd;
}
.table .table {
  background-color: #fff;
}
.table-condensed > thead > tr > th,
.table-condensed > tbody > tr > th,
.table-condensed > tfoot > tr > th,
.table-condensed > thead > tr > td,
.table-condensed > tbody > tr > td,
.table-condensed > tfoot > tr > td {
  padding: 5px;
}
.table-bordered {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > tbody > tr > th,
.table-bordered > tfoot > tr > th,
.table-bordered > thead > tr > td,
.table-bordered > tbody > tr > td,
.table-bordered > tfoot > tr > td {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > thead > tr > td {
  border-bottom-width: 2px;
}
.table-striped > tbody > tr:nth-of-type(odd) {
  background-color: #f9f9f9;
}
.table-hover > tbody > tr:hover {
  background-color: #f5f5f5;
}
table col[class*="col-"] {
  position: static;
  float: none;
  display: table-column;
}
table td[class*="col-"],
table th[class*="col-"] {
  position: static;
  float: none;
  display: table-cell;
}
.table > thead > tr > td.active,
.table > tbody > tr > td.active,
.table > tfoot > tr > td.active,
.table > thead > tr > th.active,
.table > tbody > tr > th.active,
.table > tfoot > tr > th.active,
.table > thead > tr.active > td,
.table > tbody > tr.active > td,
.table > tfoot > tr.active > td,
.table > thead > tr.active > th,
.table > tbody > tr.active > th,
.table > tfoot > tr.active > th {
  background-color: #f5f5f5;
}
.table-hover > tbody > tr > td.active:hover,
.table-hover > tbody > tr > th.active:hover,
.table-hover > tbody > tr.active:hover > td,
.table-hover > tbody > tr:hover > .active,
.table-hover > tbody > tr.active:hover > th {
  background-color: #e8e8e8;
}
.table > thead > tr > td.success,
.table > tbody > tr > td.success,
.table > tfoot > tr > td.success,
.table > thead > tr > th.success,
.table > tbody > tr > th.success,
.table > tfoot > tr > th.success,
.table > thead > tr.success > td,
.table > tbody > tr.success > td,
.table > tfoot > tr.success > td,
.table > thead > tr.success > th,
.table > tbody > tr.success > th,
.table > tfoot > tr.success > th {
  background-color: #dff0d8;
}
.table-hover > tbody > tr > td.success:hover,
.table-hover > tbody > tr > th.success:hover,
.table-hover > tbody > tr.success:hover > td,
.table-hover > tbody > tr:hover > .success,
.table-hover > tbody > tr.success:hover > th {
  background-color: #d0e9c6;
}
.table > thead > tr > td.info,
.table > tbody > tr > td.info,
.table > tfoot > tr > td.info,
.table > thead > tr > th.info,
.table > tbody > tr > th.info,
.table > tfoot > tr > th.info,
.table > thead > tr.info > td,
.table > tbody > tr.info > td,
.table > tfoot > tr.info > td,
.table > thead > tr.info > th,
.table > tbody > tr.info > th,
.table > tfoot > tr.info > th {
  background-color: #d9edf7;
}
.table-hover > tbody > tr > td.info:hover,
.table-hover > tbody > tr > th.info:hover,
.table-hover > tbody > tr.info:hover > td,
.table-hover > tbody > tr:hover > .info,
.table-hover > tbody > tr.info:hover > th {
  background-color: #c4e3f3;
}
.table > thead > tr > td.warning,
.table > tbody > tr > td.warning,
.table > tfoot > tr > td.warning,
.table > thead > tr > th.warning,
.table > tbody > tr > th.warning,
.table > tfoot > tr > th.warning,
.table > thead > tr.warning > td,
.table > tbody > tr.warning > td,
.table > tfoot > tr.warning > td,
.table > thead > tr.warning > th,
.table > tbody > tr.warning > th,
.table > tfoot > tr.warning > th {
  background-color: #fcf8e3;
}
.table-hover > tbody > tr > td.warning:hover,
.table-hover > tbody > tr > th.warning:hover,
.table-hover > tbody > tr.warning:hover > td,
.table-hover > tbody > tr:hover > .warning,
.table-hover > tbody > tr.warning:hover > th {
  background-color: #faf2cc;
}
.table > thead > tr > td.danger,
.table > tbody > tr > td.danger,
.table > tfoot > tr > td.danger,
.table > thead > tr > th.danger,
.table > tbody > tr > th.danger,
.table > tfoot > tr > th.danger,
.table > thead > tr.danger > td,
.table > tbody > tr.danger > td,
.table > tfoot > tr.danger > td,
.table > thead > tr.danger > th,
.table > tbody > tr.danger > th,
.table > tfoot > tr.danger > th {
  background-color: #f2dede;
}
.table-hover > tbody > tr > td.danger:hover,
.table-hover > tbody > tr > th.danger:hover,
.table-hover > tbody > tr.danger:hover > td,
.table-hover > tbody > tr:hover > .danger,
.table-hover > tbody > tr.danger:hover > th {
  background-color: #ebcccc;
}
.table-responsive {
  overflow-x: auto;
  min-height: 0.01%;
}
@media screen and (max-width: 767px) {
  .table-responsive {
    width: 100%;
    margin-bottom: 13.5px;
    overflow-y: hidden;
    -ms-overflow-style: -ms-autohiding-scrollbar;
    border: 1px solid #ddd;
  }
  .table-responsive > .table {
    margin-bottom: 0;
  }
  .table-responsive > .table > thead > tr > th,
  .table-responsive > .table > tbody > tr > th,
  .table-responsive > .table > tfoot > tr > th,
  .table-responsive > .table > thead > tr > td,
  .table-responsive > .table > tbody > tr > td,
  .table-responsive > .table > tfoot > tr > td {
    white-space: nowrap;
  }
  .table-responsive > .table-bordered {
    border: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:first-child,
  .table-responsive > .table-bordered > tbody > tr > th:first-child,
  .table-responsive > .table-bordered > tfoot > tr > th:first-child,
  .table-responsive > .table-bordered > thead > tr > td:first-child,
  .table-responsive > .table-bordered > tbody > tr > td:first-child,
  .table-responsive > .table-bordered > tfoot > tr > td:first-child {
    border-left: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:last-child,
  .table-responsive > .table-bordered > tbody > tr > th:last-child,
  .table-responsive > .table-bordered > tfoot > tr > th:last-child,
  .table-responsive > .table-bordered > thead > tr > td:last-child,
  .table-responsive > .table-bordered > tbody > tr > td:last-child,
  .table-responsive > .table-bordered > tfoot > tr > td:last-child {
    border-right: 0;
  }
  .table-responsive > .table-bordered > tbody > tr:last-child > th,
  .table-responsive > .table-bordered > tfoot > tr:last-child > th,
  .table-responsive > .table-bordered > tbody > tr:last-child > td,
  .table-responsive > .table-bordered > tfoot > tr:last-child > td {
    border-bottom: 0;
  }
}
fieldset {
  padding: 0;
  margin: 0;
  border: 0;
  min-width: 0;
}
legend {
  display: block;
  width: 100%;
  padding: 0;
  margin-bottom: 18px;
  font-size: 19.5px;
  line-height: inherit;
  color: #333333;
  border: 0;
  border-bottom: 1px solid #e5e5e5;
}
label {
  display: inline-block;
  max-width: 100%;
  margin-bottom: 5px;
  font-weight: bold;
}
input[type="search"] {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
input[type="radio"],
input[type="checkbox"] {
  margin: 4px 0 0;
  margin-top: 1px \9;
  line-height: normal;
}
input[type="file"] {
  display: block;
}
input[type="range"] {
  display: block;
  width: 100%;
}
select[multiple],
select[size] {
  height: auto;
}
input[type="file"]:focus,
input[type="radio"]:focus,
input[type="checkbox"]:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
output {
  display: block;
  padding-top: 7px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
}
.form-control {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
}
.form-control:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.form-control::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.form-control:-ms-input-placeholder {
  color: #999;
}
.form-control::-webkit-input-placeholder {
  color: #999;
}
.form-control::-ms-expand {
  border: 0;
  background-color: transparent;
}
.form-control[disabled],
.form-control[readonly],
fieldset[disabled] .form-control {
  background-color: #eeeeee;
  opacity: 1;
}
.form-control[disabled],
fieldset[disabled] .form-control {
  cursor: not-allowed;
}
textarea.form-control {
  height: auto;
}
input[type="search"] {
  -webkit-appearance: none;
}
@media screen and (-webkit-min-device-pixel-ratio: 0) {
  input[type="date"].form-control,
  input[type="time"].form-control,
  input[type="datetime-local"].form-control,
  input[type="month"].form-control {
    line-height: 32px;
  }
  input[type="date"].input-sm,
  input[type="time"].input-sm,
  input[type="datetime-local"].input-sm,
  input[type="month"].input-sm,
  .input-group-sm input[type="date"],
  .input-group-sm input[type="time"],
  .input-group-sm input[type="datetime-local"],
  .input-group-sm input[type="month"] {
    line-height: 30px;
  }
  input[type="date"].input-lg,
  input[type="time"].input-lg,
  input[type="datetime-local"].input-lg,
  input[type="month"].input-lg,
  .input-group-lg input[type="date"],
  .input-group-lg input[type="time"],
  .input-group-lg input[type="datetime-local"],
  .input-group-lg input[type="month"] {
    line-height: 45px;
  }
}
.form-group {
  margin-bottom: 15px;
}
.radio,
.checkbox {
  position: relative;
  display: block;
  margin-top: 10px;
  margin-bottom: 10px;
}
.radio label,
.checkbox label {
  min-height: 18px;
  padding-left: 20px;
  margin-bottom: 0;
  font-weight: normal;
  cursor: pointer;
}
.radio input[type="radio"],
.radio-inline input[type="radio"],
.checkbox input[type="checkbox"],
.checkbox-inline input[type="checkbox"] {
  position: absolute;
  margin-left: -20px;
  margin-top: 4px \9;
}
.radio + .radio,
.checkbox + .checkbox {
  margin-top: -5px;
}
.radio-inline,
.checkbox-inline {
  position: relative;
  display: inline-block;
  padding-left: 20px;
  margin-bottom: 0;
  vertical-align: middle;
  font-weight: normal;
  cursor: pointer;
}
.radio-inline + .radio-inline,
.checkbox-inline + .checkbox-inline {
  margin-top: 0;
  margin-left: 10px;
}
input[type="radio"][disabled],
input[type="checkbox"][disabled],
input[type="radio"].disabled,
input[type="checkbox"].disabled,
fieldset[disabled] input[type="radio"],
fieldset[disabled] input[type="checkbox"] {
  cursor: not-allowed;
}
.radio-inline.disabled,
.checkbox-inline.disabled,
fieldset[disabled] .radio-inline,
fieldset[disabled] .checkbox-inline {
  cursor: not-allowed;
}
.radio.disabled label,
.checkbox.disabled label,
fieldset[disabled] .radio label,
fieldset[disabled] .checkbox label {
  cursor: not-allowed;
}
.form-control-static {
  padding-top: 7px;
  padding-bottom: 7px;
  margin-bottom: 0;
  min-height: 31px;
}
.form-control-static.input-lg,
.form-control-static.input-sm {
  padding-left: 0;
  padding-right: 0;
}
.input-sm {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-sm {
  height: 30px;
  line-height: 30px;
}
textarea.input-sm,
select[multiple].input-sm {
  height: auto;
}
.form-group-sm .form-control {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.form-group-sm select.form-control {
  height: 30px;
  line-height: 30px;
}
.form-group-sm textarea.form-control,
.form-group-sm select[multiple].form-control {
  height: auto;
}
.form-group-sm .form-control-static {
  height: 30px;
  min-height: 30px;
  padding: 6px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.input-lg {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-lg {
  height: 45px;
  line-height: 45px;
}
textarea.input-lg,
select[multiple].input-lg {
  height: auto;
}
.form-group-lg .form-control {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.form-group-lg select.form-control {
  height: 45px;
  line-height: 45px;
}
.form-group-lg textarea.form-control,
.form-group-lg select[multiple].form-control {
  height: auto;
}
.form-group-lg .form-control-static {
  height: 45px;
  min-height: 35px;
  padding: 11px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.has-feedback {
  position: relative;
}
.has-feedback .form-control {
  padding-right: 40px;
}
.form-control-feedback {
  position: absolute;
  top: 0;
  right: 0;
  z-index: 2;
  display: block;
  width: 32px;
  height: 32px;
  line-height: 32px;
  text-align: center;
  pointer-events: none;
}
.input-lg + .form-control-feedback,
.input-group-lg + .form-control-feedback,
.form-group-lg .form-control + .form-control-feedback {
  width: 45px;
  height: 45px;
  line-height: 45px;
}
.input-sm + .form-control-feedback,
.input-group-sm + .form-control-feedback,
.form-group-sm .form-control + .form-control-feedback {
  width: 30px;
  height: 30px;
  line-height: 30px;
}
.has-success .help-block,
.has-success .control-label,
.has-success .radio,
.has-success .checkbox,
.has-success .radio-inline,
.has-success .checkbox-inline,
.has-success.radio label,
.has-success.checkbox label,
.has-success.radio-inline label,
.has-success.checkbox-inline label {
  color: #3c763d;
}
.has-success .form-control {
  border-color: #3c763d;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-success .form-control:focus {
  border-color: #2b542c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
}
.has-success .input-group-addon {
  color: #3c763d;
  border-color: #3c763d;
  background-color: #dff0d8;
}
.has-success .form-control-feedback {
  color: #3c763d;
}
.has-warning .help-block,
.has-warning .control-label,
.has-warning .radio,
.has-warning .checkbox,
.has-warning .radio-inline,
.has-warning .checkbox-inline,
.has-warning.radio label,
.has-warning.checkbox label,
.has-warning.radio-inline label,
.has-warning.checkbox-inline label {
  color: #8a6d3b;
}
.has-warning .form-control {
  border-color: #8a6d3b;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-warning .form-control:focus {
  border-color: #66512c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
}
.has-warning .input-group-addon {
  color: #8a6d3b;
  border-color: #8a6d3b;
  background-color: #fcf8e3;
}
.has-warning .form-control-feedback {
  color: #8a6d3b;
}
.has-error .help-block,
.has-error .control-label,
.has-error .radio,
.has-error .checkbox,
.has-error .radio-inline,
.has-error .checkbox-inline,
.has-error.radio label,
.has-error.checkbox label,
.has-error.radio-inline label,
.has-error.checkbox-inline label {
  color: #a94442;
}
.has-error .form-control {
  border-color: #a94442;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-error .form-control:focus {
  border-color: #843534;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
}
.has-error .input-group-addon {
  color: #a94442;
  border-color: #a94442;
  background-color: #f2dede;
}
.has-error .form-control-feedback {
  color: #a94442;
}
.has-feedback label ~ .form-control-feedback {
  top: 23px;
}
.has-feedback label.sr-only ~ .form-control-feedback {
  top: 0;
}
.help-block {
  display: block;
  margin-top: 5px;
  margin-bottom: 10px;
  color: #404040;
}
@media (min-width: 768px) {
  .form-inline .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .form-inline .form-control-static {
    display: inline-block;
  }
  .form-inline .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .form-inline .input-group .input-group-addon,
  .form-inline .input-group .input-group-btn,
  .form-inline .input-group .form-control {
    width: auto;
  }
  .form-inline .input-group > .form-control {
    width: 100%;
  }
  .form-inline .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio,
  .form-inline .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio label,
  .form-inline .checkbox label {
    padding-left: 0;
  }
  .form-inline .radio input[type="radio"],
  .form-inline .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .form-inline .has-feedback .form-control-feedback {
    top: 0;
  }
}
.form-horizontal .radio,
.form-horizontal .checkbox,
.form-horizontal .radio-inline,
.form-horizontal .checkbox-inline {
  margin-top: 0;
  margin-bottom: 0;
  padding-top: 7px;
}
.form-horizontal .radio,
.form-horizontal .checkbox {
  min-height: 25px;
}
.form-horizontal .form-group {
  margin-left: 0px;
  margin-right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .control-label {
    text-align: right;
    margin-bottom: 0;
    padding-top: 7px;
  }
}
.form-horizontal .has-feedback .form-control-feedback {
  right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .form-group-lg .control-label {
    padding-top: 11px;
    font-size: 17px;
  }
}
@media (min-width: 768px) {
  .form-horizontal .form-group-sm .control-label {
    padding-top: 6px;
    font-size: 12px;
  }
}
.btn {
  display: inline-block;
  margin-bottom: 0;
  font-weight: normal;
  text-align: center;
  vertical-align: middle;
  touch-action: manipulation;
  cursor: pointer;
  background-image: none;
  border: 1px solid transparent;
  white-space: nowrap;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  border-radius: 2px;
  -webkit-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
}
.btn:focus,
.btn:active:focus,
.btn.active:focus,
.btn.focus,
.btn:active.focus,
.btn.active.focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
.btn:hover,
.btn:focus,
.btn.focus {
  color: #333;
  text-decoration: none;
}
.btn:active,
.btn.active {
  outline: 0;
  background-image: none;
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn.disabled,
.btn[disabled],
fieldset[disabled] .btn {
  cursor: not-allowed;
  opacity: 0.65;
  filter: alpha(opacity=65);
  -webkit-box-shadow: none;
  box-shadow: none;
}
a.btn.disabled,
fieldset[disabled] a.btn {
  pointer-events: none;
}
.btn-default {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.btn-default:focus,
.btn-default.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.btn-default:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active:hover,
.btn-default.active:hover,
.open > .dropdown-toggle.btn-default:hover,
.btn-default:active:focus,
.btn-default.active:focus,
.open > .dropdown-toggle.btn-default:focus,
.btn-default:active.focus,
.btn-default.active.focus,
.open > .dropdown-toggle.btn-default.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  background-image: none;
}
.btn-default.disabled:hover,
.btn-default[disabled]:hover,
fieldset[disabled] .btn-default:hover,
.btn-default.disabled:focus,
.btn-default[disabled]:focus,
fieldset[disabled] .btn-default:focus,
.btn-default.disabled.focus,
.btn-default[disabled].focus,
fieldset[disabled] .btn-default.focus {
  background-color: #fff;
  border-color: #ccc;
}
.btn-default .badge {
  color: #fff;
  background-color: #333;
}
.btn-primary {
  color: #fff;
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary:focus,
.btn-primary.focus {
  color: #fff;
  background-color: #286090;
  border-color: #122b40;
}
.btn-primary:hover {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active:hover,
.btn-primary.active:hover,
.open > .dropdown-toggle.btn-primary:hover,
.btn-primary:active:focus,
.btn-primary.active:focus,
.open > .dropdown-toggle.btn-primary:focus,
.btn-primary:active.focus,
.btn-primary.active.focus,
.open > .dropdown-toggle.btn-primary.focus {
  color: #fff;
  background-color: #204d74;
  border-color: #122b40;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  background-image: none;
}
.btn-primary.disabled:hover,
.btn-primary[disabled]:hover,
fieldset[disabled] .btn-primary:hover,
.btn-primary.disabled:focus,
.btn-primary[disabled]:focus,
fieldset[disabled] .btn-primary:focus,
.btn-primary.disabled.focus,
.btn-primary[disabled].focus,
fieldset[disabled] .btn-primary.focus {
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary .badge {
  color: #337ab7;
  background-color: #fff;
}
.btn-success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success:focus,
.btn-success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.btn-success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active:hover,
.btn-success.active:hover,
.open > .dropdown-toggle.btn-success:hover,
.btn-success:active:focus,
.btn-success.active:focus,
.open > .dropdown-toggle.btn-success:focus,
.btn-success:active.focus,
.btn-success.active.focus,
.open > .dropdown-toggle.btn-success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  background-image: none;
}
.btn-success.disabled:hover,
.btn-success[disabled]:hover,
fieldset[disabled] .btn-success:hover,
.btn-success.disabled:focus,
.btn-success[disabled]:focus,
fieldset[disabled] .btn-success:focus,
.btn-success.disabled.focus,
.btn-success[disabled].focus,
fieldset[disabled] .btn-success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.btn-info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info:focus,
.btn-info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.btn-info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active:hover,
.btn-info.active:hover,
.open > .dropdown-toggle.btn-info:hover,
.btn-info:active:focus,
.btn-info.active:focus,
.open > .dropdown-toggle.btn-info:focus,
.btn-info:active.focus,
.btn-info.active.focus,
.open > .dropdown-toggle.btn-info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  background-image: none;
}
.btn-info.disabled:hover,
.btn-info[disabled]:hover,
fieldset[disabled] .btn-info:hover,
.btn-info.disabled:focus,
.btn-info[disabled]:focus,
fieldset[disabled] .btn-info:focus,
.btn-info.disabled.focus,
.btn-info[disabled].focus,
fieldset[disabled] .btn-info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.btn-warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning:focus,
.btn-warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.btn-warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active:hover,
.btn-warning.active:hover,
.open > .dropdown-toggle.btn-warning:hover,
.btn-warning:active:focus,
.btn-warning.active:focus,
.open > .dropdown-toggle.btn-warning:focus,
.btn-warning:active.focus,
.btn-warning.active.focus,
.open > .dropdown-toggle.btn-warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  background-image: none;
}
.btn-warning.disabled:hover,
.btn-warning[disabled]:hover,
fieldset[disabled] .btn-warning:hover,
.btn-warning.disabled:focus,
.btn-warning[disabled]:focus,
fieldset[disabled] .btn-warning:focus,
.btn-warning.disabled.focus,
.btn-warning[disabled].focus,
fieldset[disabled] .btn-warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.btn-danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger:focus,
.btn-danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.btn-danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active:hover,
.btn-danger.active:hover,
.open > .dropdown-toggle.btn-danger:hover,
.btn-danger:active:focus,
.btn-danger.active:focus,
.open > .dropdown-toggle.btn-danger:focus,
.btn-danger:active.focus,
.btn-danger.active.focus,
.open > .dropdown-toggle.btn-danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  background-image: none;
}
.btn-danger.disabled:hover,
.btn-danger[disabled]:hover,
fieldset[disabled] .btn-danger:hover,
.btn-danger.disabled:focus,
.btn-danger[disabled]:focus,
fieldset[disabled] .btn-danger:focus,
.btn-danger.disabled.focus,
.btn-danger[disabled].focus,
fieldset[disabled] .btn-danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger .badge {
  color: #d9534f;
  background-color: #fff;
}
.btn-link {
  color: #337ab7;
  font-weight: normal;
  border-radius: 0;
}
.btn-link,
.btn-link:active,
.btn-link.active,
.btn-link[disabled],
fieldset[disabled] .btn-link {
  background-color: transparent;
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn-link,
.btn-link:hover,
.btn-link:focus,
.btn-link:active {
  border-color: transparent;
}
.btn-link:hover,
.btn-link:focus {
  color: #23527c;
  text-decoration: underline;
  background-color: transparent;
}
.btn-link[disabled]:hover,
fieldset[disabled] .btn-link:hover,
.btn-link[disabled]:focus,
fieldset[disabled] .btn-link:focus {
  color: #777777;
  text-decoration: none;
}
.btn-lg,
.btn-group-lg > .btn {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.btn-sm,
.btn-group-sm > .btn {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-xs,
.btn-group-xs > .btn {
  padding: 1px 5px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-block {
  display: block;
  width: 100%;
}
.btn-block + .btn-block {
  margin-top: 5px;
}
input[type="submit"].btn-block,
input[type="reset"].btn-block,
input[type="button"].btn-block {
  width: 100%;
}
.fade {
  opacity: 0;
  -webkit-transition: opacity 0.15s linear;
  -o-transition: opacity 0.15s linear;
  transition: opacity 0.15s linear;
}
.fade.in {
  opacity: 1;
}
.collapse {
  display: none;
}
.collapse.in {
  display: block;
}
tr.collapse.in {
  display: table-row;
}
tbody.collapse.in {
  display: table-row-group;
}
.collapsing {
  position: relative;
  height: 0;
  overflow: hidden;
  -webkit-transition-property: height, visibility;
  transition-property: height, visibility;
  -webkit-transition-duration: 0.35s;
  transition-duration: 0.35s;
  -webkit-transition-timing-function: ease;
  transition-timing-function: ease;
}
.caret {
  display: inline-block;
  width: 0;
  height: 0;
  margin-left: 2px;
  vertical-align: middle;
  border-top: 4px dashed;
  border-top: 4px solid \9;
  border-right: 4px solid transparent;
  border-left: 4px solid transparent;
}
.dropup,
.dropdown {
  position: relative;
}
.dropdown-toggle:focus {
  outline: 0;
}
.dropdown-menu {
  position: absolute;
  top: 100%;
  left: 0;
  z-index: 1000;
  display: none;
  float: left;
  min-width: 160px;
  padding: 5px 0;
  margin: 2px 0 0;
  list-style: none;
  font-size: 13px;
  text-align: left;
  background-color: #fff;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.15);
  border-radius: 2px;
  -webkit-box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  background-clip: padding-box;
}
.dropdown-menu.pull-right {
  right: 0;
  left: auto;
}
.dropdown-menu .divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.dropdown-menu > li > a {
  display: block;
  padding: 3px 20px;
  clear: both;
  font-weight: normal;
  line-height: 1.42857143;
  color: #333333;
  white-space: nowrap;
}
.dropdown-menu > li > a:hover,
.dropdown-menu > li > a:focus {
  text-decoration: none;
  color: #262626;
  background-color: #f5f5f5;
}
.dropdown-menu > .active > a,
.dropdown-menu > .active > a:hover,
.dropdown-menu > .active > a:focus {
  color: #fff;
  text-decoration: none;
  outline: 0;
  background-color: #337ab7;
}
.dropdown-menu > .disabled > a,
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  color: #777777;
}
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  text-decoration: none;
  background-color: transparent;
  background-image: none;
  filter: progid:DXImageTransform.Microsoft.gradient(enabled = false);
  cursor: not-allowed;
}
.open > .dropdown-menu {
  display: block;
}
.open > a {
  outline: 0;
}
.dropdown-menu-right {
  left: auto;
  right: 0;
}
.dropdown-menu-left {
  left: 0;
  right: auto;
}
.dropdown-header {
  display: block;
  padding: 3px 20px;
  font-size: 12px;
  line-height: 1.42857143;
  color: #777777;
  white-space: nowrap;
}
.dropdown-backdrop {
  position: fixed;
  left: 0;
  right: 0;
  bottom: 0;
  top: 0;
  z-index: 990;
}
.pull-right > .dropdown-menu {
  right: 0;
  left: auto;
}
.dropup .caret,
.navbar-fixed-bottom .dropdown .caret {
  border-top: 0;
  border-bottom: 4px dashed;
  border-bottom: 4px solid \9;
  content: "";
}
.dropup .dropdown-menu,
.navbar-fixed-bottom .dropdown .dropdown-menu {
  top: auto;
  bottom: 100%;
  margin-bottom: 2px;
}
@media (min-width: 541px) {
  .navbar-right .dropdown-menu {
    left: auto;
    right: 0;
  }
  .navbar-right .dropdown-menu-left {
    left: 0;
    right: auto;
  }
}
.btn-group,
.btn-group-vertical {
  position: relative;
  display: inline-block;
  vertical-align: middle;
}
.btn-group > .btn,
.btn-group-vertical > .btn {
  position: relative;
  float: left;
}
.btn-group > .btn:hover,
.btn-group-vertical > .btn:hover,
.btn-group > .btn:focus,
.btn-group-vertical > .btn:focus,
.btn-group > .btn:active,
.btn-group-vertical > .btn:active,
.btn-group > .btn.active,
.btn-group-vertical > .btn.active {
  z-index: 2;
}
.btn-group .btn + .btn,
.btn-group .btn + .btn-group,
.btn-group .btn-group + .btn,
.btn-group .btn-group + .btn-group {
  margin-left: -1px;
}
.btn-toolbar {
  margin-left: -5px;
}
.btn-toolbar .btn,
.btn-toolbar .btn-group,
.btn-toolbar .input-group {
  float: left;
}
.btn-toolbar > .btn,
.btn-toolbar > .btn-group,
.btn-toolbar > .input-group {
  margin-left: 5px;
}
.btn-group > .btn:not(:first-child):not(:last-child):not(.dropdown-toggle) {
  border-radius: 0;
}
.btn-group > .btn:first-child {
  margin-left: 0;
}
.btn-group > .btn:first-child:not(:last-child):not(.dropdown-toggle) {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn:last-child:not(:first-child),
.btn-group > .dropdown-toggle:not(:first-child) {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group > .btn-group {
  float: left;
}
.btn-group > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group .dropdown-toggle:active,
.btn-group.open .dropdown-toggle {
  outline: 0;
}
.btn-group > .btn + .dropdown-toggle {
  padding-left: 8px;
  padding-right: 8px;
}
.btn-group > .btn-lg + .dropdown-toggle {
  padding-left: 12px;
  padding-right: 12px;
}
.btn-group.open .dropdown-toggle {
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn-group.open .dropdown-toggle.btn-link {
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn .caret {
  margin-left: 0;
}
.btn-lg .caret {
  border-width: 5px 5px 0;
  border-bottom-width: 0;
}
.dropup .btn-lg .caret {
  border-width: 0 5px 5px;
}
.btn-group-vertical > .btn,
.btn-group-vertical > .btn-group,
.btn-group-vertical > .btn-group > .btn {
  display: block;
  float: none;
  width: 100%;
  max-width: 100%;
}
.btn-group-vertical > .btn-group > .btn {
  float: none;
}
.btn-group-vertical > .btn + .btn,
.btn-group-vertical > .btn + .btn-group,
.btn-group-vertical > .btn-group + .btn,
.btn-group-vertical > .btn-group + .btn-group {
  margin-top: -1px;
  margin-left: 0;
}
.btn-group-vertical > .btn:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.btn-group-vertical > .btn:first-child:not(:last-child) {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn:last-child:not(:first-child) {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
.btn-group-vertical > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.btn-group-justified {
  display: table;
  width: 100%;
  table-layout: fixed;
  border-collapse: separate;
}
.btn-group-justified > .btn,
.btn-group-justified > .btn-group {
  float: none;
  display: table-cell;
  width: 1%;
}
.btn-group-justified > .btn-group .btn {
  width: 100%;
}
.btn-group-justified > .btn-group .dropdown-menu {
  left: auto;
}
[data-toggle="buttons"] > .btn input[type="radio"],
[data-toggle="buttons"] > .btn-group > .btn input[type="radio"],
[data-toggle="buttons"] > .btn input[type="checkbox"],
[data-toggle="buttons"] > .btn-group > .btn input[type="checkbox"] {
  position: absolute;
  clip: rect(0, 0, 0, 0);
  pointer-events: none;
}
.input-group {
  position: relative;
  display: table;
  border-collapse: separate;
}
.input-group[class*="col-"] {
  float: none;
  padding-left: 0;
  padding-right: 0;
}
.input-group .form-control {
  position: relative;
  z-index: 2;
  float: left;
  width: 100%;
  margin-bottom: 0;
}
.input-group .form-control:focus {
  z-index: 3;
}
.input-group-lg > .form-control,
.input-group-lg > .input-group-addon,
.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-group-lg > .form-control,
select.input-group-lg > .input-group-addon,
select.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  line-height: 45px;
}
textarea.input-group-lg > .form-control,
textarea.input-group-lg > .input-group-addon,
textarea.input-group-lg > .input-group-btn > .btn,
select[multiple].input-group-lg > .form-control,
select[multiple].input-group-lg > .input-group-addon,
select[multiple].input-group-lg > .input-group-btn > .btn {
  height: auto;
}
.input-group-sm > .form-control,
.input-group-sm > .input-group-addon,
.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-group-sm > .form-control,
select.input-group-sm > .input-group-addon,
select.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  line-height: 30px;
}
textarea.input-group-sm > .form-control,
textarea.input-group-sm > .input-group-addon,
textarea.input-group-sm > .input-group-btn > .btn,
select[multiple].input-group-sm > .form-control,
select[multiple].input-group-sm > .input-group-addon,
select[multiple].input-group-sm > .input-group-btn > .btn {
  height: auto;
}
.input-group-addon,
.input-group-btn,
.input-group .form-control {
  display: table-cell;
}
.input-group-addon:not(:first-child):not(:last-child),
.input-group-btn:not(:first-child):not(:last-child),
.input-group .form-control:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.input-group-addon,
.input-group-btn {
  width: 1%;
  white-space: nowrap;
  vertical-align: middle;
}
.input-group-addon {
  padding: 6px 12px;
  font-size: 13px;
  font-weight: normal;
  line-height: 1;
  color: #555555;
  text-align: center;
  background-color: #eeeeee;
  border: 1px solid #ccc;
  border-radius: 2px;
}
.input-group-addon.input-sm {
  padding: 5px 10px;
  font-size: 12px;
  border-radius: 1px;
}
.input-group-addon.input-lg {
  padding: 10px 16px;
  font-size: 17px;
  border-radius: 3px;
}
.input-group-addon input[type="radio"],
.input-group-addon input[type="checkbox"] {
  margin-top: 0;
}
.input-group .form-control:first-child,
.input-group-addon:first-child,
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group > .btn,
.input-group-btn:first-child > .dropdown-toggle,
.input-group-btn:last-child > .btn:not(:last-child):not(.dropdown-toggle),
.input-group-btn:last-child > .btn-group:not(:last-child) > .btn {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.input-group-addon:first-child {
  border-right: 0;
}
.input-group .form-control:last-child,
.input-group-addon:last-child,
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group > .btn,
.input-group-btn:last-child > .dropdown-toggle,
.input-group-btn:first-child > .btn:not(:first-child),
.input-group-btn:first-child > .btn-group:not(:first-child) > .btn {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.input-group-addon:last-child {
  border-left: 0;
}
.input-group-btn {
  position: relative;
  font-size: 0;
  white-space: nowrap;
}
.input-group-btn > .btn {
  position: relative;
}
.input-group-btn > .btn + .btn {
  margin-left: -1px;
}
.input-group-btn > .btn:hover,
.input-group-btn > .btn:focus,
.input-group-btn > .btn:active {
  z-index: 2;
}
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group {
  margin-right: -1px;
}
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group {
  z-index: 2;
  margin-left: -1px;
}
.nav {
  margin-bottom: 0;
  padding-left: 0;
  list-style: none;
}
.nav > li {
  position: relative;
  display: block;
}
.nav > li > a {
  position: relative;
  display: block;
  padding: 10px 15px;
}
.nav > li > a:hover,
.nav > li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.nav > li.disabled > a {
  color: #777777;
}
.nav > li.disabled > a:hover,
.nav > li.disabled > a:focus {
  color: #777777;
  text-decoration: none;
  background-color: transparent;
  cursor: not-allowed;
}
.nav .open > a,
.nav .open > a:hover,
.nav .open > a:focus {
  background-color: #eeeeee;
  border-color: #337ab7;
}
.nav .nav-divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.nav > li > a > img {
  max-width: none;
}
.nav-tabs {
  border-bottom: 1px solid #ddd;
}
.nav-tabs > li {
  float: left;
  margin-bottom: -1px;
}
.nav-tabs > li > a {
  margin-right: 2px;
  line-height: 1.42857143;
  border: 1px solid transparent;
  border-radius: 2px 2px 0 0;
}
.nav-tabs > li > a:hover {
  border-color: #eeeeee #eeeeee #ddd;
}
.nav-tabs > li.active > a,
.nav-tabs > li.active > a:hover,
.nav-tabs > li.active > a:focus {
  color: #555555;
  background-color: #fff;
  border: 1px solid #ddd;
  border-bottom-color: transparent;
  cursor: default;
}
.nav-tabs.nav-justified {
  width: 100%;
  border-bottom: 0;
}
.nav-tabs.nav-justified > li {
  float: none;
}
.nav-tabs.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-tabs.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-tabs.nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs.nav-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs.nav-justified > .active > a,
.nav-tabs.nav-justified > .active > a:hover,
.nav-tabs.nav-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs.nav-justified > .active > a,
  .nav-tabs.nav-justified > .active > a:hover,
  .nav-tabs.nav-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.nav-pills > li {
  float: left;
}
.nav-pills > li > a {
  border-radius: 2px;
}
.nav-pills > li + li {
  margin-left: 2px;
}
.nav-pills > li.active > a,
.nav-pills > li.active > a:hover,
.nav-pills > li.active > a:focus {
  color: #fff;
  background-color: #337ab7;
}
.nav-stacked > li {
  float: none;
}
.nav-stacked > li + li {
  margin-top: 2px;
  margin-left: 0;
}
.nav-justified {
  width: 100%;
}
.nav-justified > li {
  float: none;
}
.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs-justified {
  border-bottom: 0;
}
.nav-tabs-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs-justified > .active > a,
.nav-tabs-justified > .active > a:hover,
.nav-tabs-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs-justified > .active > a,
  .nav-tabs-justified > .active > a:hover,
  .nav-tabs-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.tab-content > .tab-pane {
  display: none;
}
.tab-content > .active {
  display: block;
}
.nav-tabs .dropdown-menu {
  margin-top: -1px;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar {
  position: relative;
  min-height: 30px;
  margin-bottom: 18px;
  border: 1px solid transparent;
}
@media (min-width: 541px) {
  .navbar {
    border-radius: 2px;
  }
}
@media (min-width: 541px) {
  .navbar-header {
    float: left;
  }
}
.navbar-collapse {
  overflow-x: visible;
  padding-right: 0px;
  padding-left: 0px;
  border-top: 1px solid transparent;
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1);
  -webkit-overflow-scrolling: touch;
}
.navbar-collapse.in {
  overflow-y: auto;
}
@media (min-width: 541px) {
  .navbar-collapse {
    width: auto;
    border-top: 0;
    box-shadow: none;
  }
  .navbar-collapse.collapse {
    display: block !important;
    height: auto !important;
    padding-bottom: 0;
    overflow: visible !important;
  }
  .navbar-collapse.in {
    overflow-y: visible;
  }
  .navbar-fixed-top .navbar-collapse,
  .navbar-static-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    padding-left: 0;
    padding-right: 0;
  }
}
.navbar-fixed-top .navbar-collapse,
.navbar-fixed-bottom .navbar-collapse {
  max-height: 340px;
}
@media (max-device-width: 540px) and (orientation: landscape) {
  .navbar-fixed-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    max-height: 200px;
  }
}
.container > .navbar-header,
.container-fluid > .navbar-header,
.container > .navbar-collapse,
.container-fluid > .navbar-collapse {
  margin-right: 0px;
  margin-left: 0px;
}
@media (min-width: 541px) {
  .container > .navbar-header,
  .container-fluid > .navbar-header,
  .container > .navbar-collapse,
  .container-fluid > .navbar-collapse {
    margin-right: 0;
    margin-left: 0;
  }
}
.navbar-static-top {
  z-index: 1000;
  border-width: 0 0 1px;
}
@media (min-width: 541px) {
  .navbar-static-top {
    border-radius: 0;
  }
}
.navbar-fixed-top,
.navbar-fixed-bottom {
  position: fixed;
  right: 0;
  left: 0;
  z-index: 1030;
}
@media (min-width: 541px) {
  .navbar-fixed-top,
  .navbar-fixed-bottom {
    border-radius: 0;
  }
}
.navbar-fixed-top {
  top: 0;
  border-width: 0 0 1px;
}
.navbar-fixed-bottom {
  bottom: 0;
  margin-bottom: 0;
  border-width: 1px 0 0;
}
.navbar-brand {
  float: left;
  padding: 6px 0px;
  font-size: 17px;
  line-height: 18px;
  height: 30px;
}
.navbar-brand:hover,
.navbar-brand:focus {
  text-decoration: none;
}
.navbar-brand > img {
  display: block;
}
@media (min-width: 541px) {
  .navbar > .container .navbar-brand,
  .navbar > .container-fluid .navbar-brand {
    margin-left: 0px;
  }
}
.navbar-toggle {
  position: relative;
  float: right;
  margin-right: 0px;
  padding: 9px 10px;
  margin-top: -2px;
  margin-bottom: -2px;
  background-color: transparent;
  background-image: none;
  border: 1px solid transparent;
  border-radius: 2px;
}
.navbar-toggle:focus {
  outline: 0;
}
.navbar-toggle .icon-bar {
  display: block;
  width: 22px;
  height: 2px;
  border-radius: 1px;
}
.navbar-toggle .icon-bar + .icon-bar {
  margin-top: 4px;
}
@media (min-width: 541px) {
  .navbar-toggle {
    display: none;
  }
}
.navbar-nav {
  margin: 3px 0px;
}
.navbar-nav > li > a {
  padding-top: 10px;
  padding-bottom: 10px;
  line-height: 18px;
}
@media (max-width: 540px) {
  .navbar-nav .open .dropdown-menu {
    position: static;
    float: none;
    width: auto;
    margin-top: 0;
    background-color: transparent;
    border: 0;
    box-shadow: none;
  }
  .navbar-nav .open .dropdown-menu > li > a,
  .navbar-nav .open .dropdown-menu .dropdown-header {
    padding: 5px 15px 5px 25px;
  }
  .navbar-nav .open .dropdown-menu > li > a {
    line-height: 18px;
  }
  .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-nav .open .dropdown-menu > li > a:focus {
    background-image: none;
  }
}
@media (min-width: 541px) {
  .navbar-nav {
    float: left;
    margin: 0;
  }
  .navbar-nav > li {
    float: left;
  }
  .navbar-nav > li > a {
    padding-top: 6px;
    padding-bottom: 6px;
  }
}
.navbar-form {
  margin-left: 0px;
  margin-right: 0px;
  padding: 10px 0px;
  border-top: 1px solid transparent;
  border-bottom: 1px solid transparent;
  -webkit-box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  margin-top: -1px;
  margin-bottom: -1px;
}
@media (min-width: 768px) {
  .navbar-form .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .navbar-form .form-control-static {
    display: inline-block;
  }
  .navbar-form .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .navbar-form .input-group .input-group-addon,
  .navbar-form .input-group .input-group-btn,
  .navbar-form .input-group .form-control {
    width: auto;
  }
  .navbar-form .input-group > .form-control {
    width: 100%;
  }
  .navbar-form .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio,
  .navbar-form .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio label,
  .navbar-form .checkbox label {
    padding-left: 0;
  }
  .navbar-form .radio input[type="radio"],
  .navbar-form .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .navbar-form .has-feedback .form-control-feedback {
    top: 0;
  }
}
@media (max-width: 540px) {
  .navbar-form .form-group {
    margin-bottom: 5px;
  }
  .navbar-form .form-group:last-child {
    margin-bottom: 0;
  }
}
@media (min-width: 541px) {
  .navbar-form {
    width: auto;
    border: 0;
    margin-left: 0;
    margin-right: 0;
    padding-top: 0;
    padding-bottom: 0;
    -webkit-box-shadow: none;
    box-shadow: none;
  }
}
.navbar-nav > li > .dropdown-menu {
  margin-top: 0;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar-fixed-bottom .navbar-nav > li > .dropdown-menu {
  margin-bottom: 0;
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.navbar-btn {
  margin-top: -1px;
  margin-bottom: -1px;
}
.navbar-btn.btn-sm {
  margin-top: 0px;
  margin-bottom: 0px;
}
.navbar-btn.btn-xs {
  margin-top: 4px;
  margin-bottom: 4px;
}
.navbar-text {
  margin-top: 6px;
  margin-bottom: 6px;
}
@media (min-width: 541px) {
  .navbar-text {
    float: left;
    margin-left: 0px;
    margin-right: 0px;
  }
}
@media (min-width: 541px) {
  .navbar-left {
    float: left !important;
    float: left;
  }
  .navbar-right {
    float: right !important;
    float: right;
    margin-right: 0px;
  }
  .navbar-right ~ .navbar-right {
    margin-right: 0;
  }
}
.navbar-default {
  background-color: #f8f8f8;
  border-color: #e7e7e7;
}
.navbar-default .navbar-brand {
  color: #777;
}
.navbar-default .navbar-brand:hover,
.navbar-default .navbar-brand:focus {
  color: #5e5e5e;
  background-color: transparent;
}
.navbar-default .navbar-text {
  color: #777;
}
.navbar-default .navbar-nav > li > a {
  color: #777;
}
.navbar-default .navbar-nav > li > a:hover,
.navbar-default .navbar-nav > li > a:focus {
  color: #333;
  background-color: transparent;
}
.navbar-default .navbar-nav > .active > a,
.navbar-default .navbar-nav > .active > a:hover,
.navbar-default .navbar-nav > .active > a:focus {
  color: #555;
  background-color: #e7e7e7;
}
.navbar-default .navbar-nav > .disabled > a,
.navbar-default .navbar-nav > .disabled > a:hover,
.navbar-default .navbar-nav > .disabled > a:focus {
  color: #ccc;
  background-color: transparent;
}
.navbar-default .navbar-toggle {
  border-color: #ddd;
}
.navbar-default .navbar-toggle:hover,
.navbar-default .navbar-toggle:focus {
  background-color: #ddd;
}
.navbar-default .navbar-toggle .icon-bar {
  background-color: #888;
}
.navbar-default .navbar-collapse,
.navbar-default .navbar-form {
  border-color: #e7e7e7;
}
.navbar-default .navbar-nav > .open > a,
.navbar-default .navbar-nav > .open > a:hover,
.navbar-default .navbar-nav > .open > a:focus {
  background-color: #e7e7e7;
  color: #555;
}
@media (max-width: 540px) {
  .navbar-default .navbar-nav .open .dropdown-menu > li > a {
    color: #777;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #333;
    background-color: transparent;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #555;
    background-color: #e7e7e7;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #ccc;
    background-color: transparent;
  }
}
.navbar-default .navbar-link {
  color: #777;
}
.navbar-default .navbar-link:hover {
  color: #333;
}
.navbar-default .btn-link {
  color: #777;
}
.navbar-default .btn-link:hover,
.navbar-default .btn-link:focus {
  color: #333;
}
.navbar-default .btn-link[disabled]:hover,
fieldset[disabled] .navbar-default .btn-link:hover,
.navbar-default .btn-link[disabled]:focus,
fieldset[disabled] .navbar-default .btn-link:focus {
  color: #ccc;
}
.navbar-inverse {
  background-color: #222;
  border-color: #080808;
}
.navbar-inverse .navbar-brand {
  color: #9d9d9d;
}
.navbar-inverse .navbar-brand:hover,
.navbar-inverse .navbar-brand:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-text {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a:hover,
.navbar-inverse .navbar-nav > li > a:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-nav > .active > a,
.navbar-inverse .navbar-nav > .active > a:hover,
.navbar-inverse .navbar-nav > .active > a:focus {
  color: #fff;
  background-color: #080808;
}
.navbar-inverse .navbar-nav > .disabled > a,
.navbar-inverse .navbar-nav > .disabled > a:hover,
.navbar-inverse .navbar-nav > .disabled > a:focus {
  color: #444;
  background-color: transparent;
}
.navbar-inverse .navbar-toggle {
  border-color: #333;
}
.navbar-inverse .navbar-toggle:hover,
.navbar-inverse .navbar-toggle:focus {
  background-color: #333;
}
.navbar-inverse .navbar-toggle .icon-bar {
  background-color: #fff;
}
.navbar-inverse .navbar-collapse,
.navbar-inverse .navbar-form {
  border-color: #101010;
}
.navbar-inverse .navbar-nav > .open > a,
.navbar-inverse .navbar-nav > .open > a:hover,
.navbar-inverse .navbar-nav > .open > a:focus {
  background-color: #080808;
  color: #fff;
}
@media (max-width: 540px) {
  .navbar-inverse .navbar-nav .open .dropdown-menu > .dropdown-header {
    border-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu .divider {
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a {
    color: #9d9d9d;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #fff;
    background-color: transparent;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #fff;
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #444;
    background-color: transparent;
  }
}
.navbar-inverse .navbar-link {
  color: #9d9d9d;
}
.navbar-inverse .navbar-link:hover {
  color: #fff;
}
.navbar-inverse .btn-link {
  color: #9d9d9d;
}
.navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link:focus {
  color: #fff;
}
.navbar-inverse .btn-link[disabled]:hover,
fieldset[disabled] .navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link[disabled]:focus,
fieldset[disabled] .navbar-inverse .btn-link:focus {
  color: #444;
}
.breadcrumb {
  padding: 8px 15px;
  margin-bottom: 18px;
  list-style: none;
  background-color: #f5f5f5;
  border-radius: 2px;
}
.breadcrumb > li {
  display: inline-block;
}
.breadcrumb > li + li:before {
  content: "/\00a0";
  padding: 0 5px;
  color: #5e5e5e;
}
.breadcrumb > .active {
  color: #777777;
}
.pagination {
  display: inline-block;
  padding-left: 0;
  margin: 18px 0;
  border-radius: 2px;
}
.pagination > li {
  display: inline;
}
.pagination > li > a,
.pagination > li > span {
  position: relative;
  float: left;
  padding: 6px 12px;
  line-height: 1.42857143;
  text-decoration: none;
  color: #337ab7;
  background-color: #fff;
  border: 1px solid #ddd;
  margin-left: -1px;
}
.pagination > li:first-child > a,
.pagination > li:first-child > span {
  margin-left: 0;
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.pagination > li:last-child > a,
.pagination > li:last-child > span {
  border-bottom-right-radius: 2px;
  border-top-right-radius: 2px;
}
.pagination > li > a:hover,
.pagination > li > span:hover,
.pagination > li > a:focus,
.pagination > li > span:focus {
  z-index: 2;
  color: #23527c;
  background-color: #eeeeee;
  border-color: #ddd;
}
.pagination > .active > a,
.pagination > .active > span,
.pagination > .active > a:hover,
.pagination > .active > span:hover,
.pagination > .active > a:focus,
.pagination > .active > span:focus {
  z-index: 3;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
  cursor: default;
}
.pagination > .disabled > span,
.pagination > .disabled > span:hover,
.pagination > .disabled > span:focus,
.pagination > .disabled > a,
.pagination > .disabled > a:hover,
.pagination > .disabled > a:focus {
  color: #777777;
  background-color: #fff;
  border-color: #ddd;
  cursor: not-allowed;
}
.pagination-lg > li > a,
.pagination-lg > li > span {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.pagination-lg > li:first-child > a,
.pagination-lg > li:first-child > span {
  border-bottom-left-radius: 3px;
  border-top-left-radius: 3px;
}
.pagination-lg > li:last-child > a,
.pagination-lg > li:last-child > span {
  border-bottom-right-radius: 3px;
  border-top-right-radius: 3px;
}
.pagination-sm > li > a,
.pagination-sm > li > span {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.pagination-sm > li:first-child > a,
.pagination-sm > li:first-child > span {
  border-bottom-left-radius: 1px;
  border-top-left-radius: 1px;
}
.pagination-sm > li:last-child > a,
.pagination-sm > li:last-child > span {
  border-bottom-right-radius: 1px;
  border-top-right-radius: 1px;
}
.pager {
  padding-left: 0;
  margin: 18px 0;
  list-style: none;
  text-align: center;
}
.pager li {
  display: inline;
}
.pager li > a,
.pager li > span {
  display: inline-block;
  padding: 5px 14px;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 15px;
}
.pager li > a:hover,
.pager li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.pager .next > a,
.pager .next > span {
  float: right;
}
.pager .previous > a,
.pager .previous > span {
  float: left;
}
.pager .disabled > a,
.pager .disabled > a:hover,
.pager .disabled > a:focus,
.pager .disabled > span {
  color: #777777;
  background-color: #fff;
  cursor: not-allowed;
}
.label {
  display: inline;
  padding: .2em .6em .3em;
  font-size: 75%;
  font-weight: bold;
  line-height: 1;
  color: #fff;
  text-align: center;
  white-space: nowrap;
  vertical-align: baseline;
  border-radius: .25em;
}
a.label:hover,
a.label:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.label:empty {
  display: none;
}
.btn .label {
  position: relative;
  top: -1px;
}
.label-default {
  background-color: #777777;
}
.label-default[href]:hover,
.label-default[href]:focus {
  background-color: #5e5e5e;
}
.label-primary {
  background-color: #337ab7;
}
.label-primary[href]:hover,
.label-primary[href]:focus {
  background-color: #286090;
}
.label-success {
  background-color: #5cb85c;
}
.label-success[href]:hover,
.label-success[href]:focus {
  background-color: #449d44;
}
.label-info {
  background-color: #5bc0de;
}
.label-info[href]:hover,
.label-info[href]:focus {
  background-color: #31b0d5;
}
.label-warning {
  background-color: #f0ad4e;
}
.label-warning[href]:hover,
.label-warning[href]:focus {
  background-color: #ec971f;
}
.label-danger {
  background-color: #d9534f;
}
.label-danger[href]:hover,
.label-danger[href]:focus {
  background-color: #c9302c;
}
.badge {
  display: inline-block;
  min-width: 10px;
  padding: 3px 7px;
  font-size: 12px;
  font-weight: bold;
  color: #fff;
  line-height: 1;
  vertical-align: middle;
  white-space: nowrap;
  text-align: center;
  background-color: #777777;
  border-radius: 10px;
}
.badge:empty {
  display: none;
}
.btn .badge {
  position: relative;
  top: -1px;
}
.btn-xs .badge,
.btn-group-xs > .btn .badge {
  top: 0;
  padding: 1px 5px;
}
a.badge:hover,
a.badge:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.list-group-item.active > .badge,
.nav-pills > .active > a > .badge {
  color: #337ab7;
  background-color: #fff;
}
.list-group-item > .badge {
  float: right;
}
.list-group-item > .badge + .badge {
  margin-right: 5px;
}
.nav-pills > li > a > .badge {
  margin-left: 3px;
}
.jumbotron {
  padding-top: 30px;
  padding-bottom: 30px;
  margin-bottom: 30px;
  color: inherit;
  background-color: #eeeeee;
}
.jumbotron h1,
.jumbotron .h1 {
  color: inherit;
}
.jumbotron p {
  margin-bottom: 15px;
  font-size: 20px;
  font-weight: 200;
}
.jumbotron > hr {
  border-top-color: #d5d5d5;
}
.container .jumbotron,
.container-fluid .jumbotron {
  border-radius: 3px;
  padding-left: 0px;
  padding-right: 0px;
}
.jumbotron .container {
  max-width: 100%;
}
@media screen and (min-width: 768px) {
  .jumbotron {
    padding-top: 48px;
    padding-bottom: 48px;
  }
  .container .jumbotron,
  .container-fluid .jumbotron {
    padding-left: 60px;
    padding-right: 60px;
  }
  .jumbotron h1,
  .jumbotron .h1 {
    font-size: 59px;
  }
}
.thumbnail {
  display: block;
  padding: 4px;
  margin-bottom: 18px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: border 0.2s ease-in-out;
  -o-transition: border 0.2s ease-in-out;
  transition: border 0.2s ease-in-out;
}
.thumbnail > img,
.thumbnail a > img {
  margin-left: auto;
  margin-right: auto;
}
a.thumbnail:hover,
a.thumbnail:focus,
a.thumbnail.active {
  border-color: #337ab7;
}
.thumbnail .caption {
  padding: 9px;
  color: #000;
}
.alert {
  padding: 15px;
  margin-bottom: 18px;
  border: 1px solid transparent;
  border-radius: 2px;
}
.alert h4 {
  margin-top: 0;
  color: inherit;
}
.alert .alert-link {
  font-weight: bold;
}
.alert > p,
.alert > ul {
  margin-bottom: 0;
}
.alert > p + p {
  margin-top: 5px;
}
.alert-dismissable,
.alert-dismissible {
  padding-right: 35px;
}
.alert-dismissable .close,
.alert-dismissible .close {
  position: relative;
  top: -2px;
  right: -21px;
  color: inherit;
}
.alert-success {
  background-color: #dff0d8;
  border-color: #d6e9c6;
  color: #3c763d;
}
.alert-success hr {
  border-top-color: #c9e2b3;
}
.alert-success .alert-link {
  color: #2b542c;
}
.alert-info {
  background-color: #d9edf7;
  border-color: #bce8f1;
  color: #31708f;
}
.alert-info hr {
  border-top-color: #a6e1ec;
}
.alert-info .alert-link {
  color: #245269;
}
.alert-warning {
  background-color: #fcf8e3;
  border-color: #faebcc;
  color: #8a6d3b;
}
.alert-warning hr {
  border-top-color: #f7e1b5;
}
.alert-warning .alert-link {
  color: #66512c;
}
.alert-danger {
  background-color: #f2dede;
  border-color: #ebccd1;
  color: #a94442;
}
.alert-danger hr {
  border-top-color: #e4b9c0;
}
.alert-danger .alert-link {
  color: #843534;
}
@-webkit-keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
@keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
.progress {
  overflow: hidden;
  height: 18px;
  margin-bottom: 18px;
  background-color: #f5f5f5;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
  box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
}
.progress-bar {
  float: left;
  width: 0%;
  height: 100%;
  font-size: 12px;
  line-height: 18px;
  color: #fff;
  text-align: center;
  background-color: #337ab7;
  -webkit-box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  -webkit-transition: width 0.6s ease;
  -o-transition: width 0.6s ease;
  transition: width 0.6s ease;
}
.progress-striped .progress-bar,
.progress-bar-striped {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-size: 40px 40px;
}
.progress.active .progress-bar,
.progress-bar.active {
  -webkit-animation: progress-bar-stripes 2s linear infinite;
  -o-animation: progress-bar-stripes 2s linear infinite;
  animation: progress-bar-stripes 2s linear infinite;
}
.progress-bar-success {
  background-color: #5cb85c;
}
.progress-striped .progress-bar-success {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-info {
  background-color: #5bc0de;
}
.progress-striped .progress-bar-info {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-warning {
  background-color: #f0ad4e;
}
.progress-striped .progress-bar-warning {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-danger {
  background-color: #d9534f;
}
.progress-striped .progress-bar-danger {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.media {
  margin-top: 15px;
}
.media:first-child {
  margin-top: 0;
}
.media,
.media-body {
  zoom: 1;
  overflow: hidden;
}
.media-body {
  width: 10000px;
}
.media-object {
  display: block;
}
.media-object.img-thumbnail {
  max-width: none;
}
.media-right,
.media > .pull-right {
  padding-left: 10px;
}
.media-left,
.media > .pull-left {
  padding-right: 10px;
}
.media-left,
.media-right,
.media-body {
  display: table-cell;
  vertical-align: top;
}
.media-middle {
  vertical-align: middle;
}
.media-bottom {
  vertical-align: bottom;
}
.media-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.media-list {
  padding-left: 0;
  list-style: none;
}
.list-group {
  margin-bottom: 20px;
  padding-left: 0;
}
.list-group-item {
  position: relative;
  display: block;
  padding: 10px 15px;
  margin-bottom: -1px;
  background-color: #fff;
  border: 1px solid #ddd;
}
.list-group-item:first-child {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
}
.list-group-item:last-child {
  margin-bottom: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
a.list-group-item,
button.list-group-item {
  color: #555;
}
a.list-group-item .list-group-item-heading,
button.list-group-item .list-group-item-heading {
  color: #333;
}
a.list-group-item:hover,
button.list-group-item:hover,
a.list-group-item:focus,
button.list-group-item:focus {
  text-decoration: none;
  color: #555;
  background-color: #f5f5f5;
}
button.list-group-item {
  width: 100%;
  text-align: left;
}
.list-group-item.disabled,
.list-group-item.disabled:hover,
.list-group-item.disabled:focus {
  background-color: #eeeeee;
  color: #777777;
  cursor: not-allowed;
}
.list-group-item.disabled .list-group-item-heading,
.list-group-item.disabled:hover .list-group-item-heading,
.list-group-item.disabled:focus .list-group-item-heading {
  color: inherit;
}
.list-group-item.disabled .list-group-item-text,
.list-group-item.disabled:hover .list-group-item-text,
.list-group-item.disabled:focus .list-group-item-text {
  color: #777777;
}
.list-group-item.active,
.list-group-item.active:hover,
.list-group-item.active:focus {
  z-index: 2;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.list-group-item.active .list-group-item-heading,
.list-group-item.active:hover .list-group-item-heading,
.list-group-item.active:focus .list-group-item-heading,
.list-group-item.active .list-group-item-heading > small,
.list-group-item.active:hover .list-group-item-heading > small,
.list-group-item.active:focus .list-group-item-heading > small,
.list-group-item.active .list-group-item-heading > .small,
.list-group-item.active:hover .list-group-item-heading > .small,
.list-group-item.active:focus .list-group-item-heading > .small {
  color: inherit;
}
.list-group-item.active .list-group-item-text,
.list-group-item.active:hover .list-group-item-text,
.list-group-item.active:focus .list-group-item-text {
  color: #c7ddef;
}
.list-group-item-success {
  color: #3c763d;
  background-color: #dff0d8;
}
a.list-group-item-success,
button.list-group-item-success {
  color: #3c763d;
}
a.list-group-item-success .list-group-item-heading,
button.list-group-item-success .list-group-item-heading {
  color: inherit;
}
a.list-group-item-success:hover,
button.list-group-item-success:hover,
a.list-group-item-success:focus,
button.list-group-item-success:focus {
  color: #3c763d;
  background-color: #d0e9c6;
}
a.list-group-item-success.active,
button.list-group-item-success.active,
a.list-group-item-success.active:hover,
button.list-group-item-success.active:hover,
a.list-group-item-success.active:focus,
button.list-group-item-success.active:focus {
  color: #fff;
  background-color: #3c763d;
  border-color: #3c763d;
}
.list-group-item-info {
  color: #31708f;
  background-color: #d9edf7;
}
a.list-group-item-info,
button.list-group-item-info {
  color: #31708f;
}
a.list-group-item-info .list-group-item-heading,
button.list-group-item-info .list-group-item-heading {
  color: inherit;
}
a.list-group-item-info:hover,
button.list-group-item-info:hover,
a.list-group-item-info:focus,
button.list-group-item-info:focus {
  color: #31708f;
  background-color: #c4e3f3;
}
a.list-group-item-info.active,
button.list-group-item-info.active,
a.list-group-item-info.active:hover,
button.list-group-item-info.active:hover,
a.list-group-item-info.active:focus,
button.list-group-item-info.active:focus {
  color: #fff;
  background-color: #31708f;
  border-color: #31708f;
}
.list-group-item-warning {
  color: #8a6d3b;
  background-color: #fcf8e3;
}
a.list-group-item-warning,
button.list-group-item-warning {
  color: #8a6d3b;
}
a.list-group-item-warning .list-group-item-heading,
button.list-group-item-warning .list-group-item-heading {
  color: inherit;
}
a.list-group-item-warning:hover,
button.list-group-item-warning:hover,
a.list-group-item-warning:focus,
button.list-group-item-warning:focus {
  color: #8a6d3b;
  background-color: #faf2cc;
}
a.list-group-item-warning.active,
button.list-group-item-warning.active,
a.list-group-item-warning.active:hover,
button.list-group-item-warning.active:hover,
a.list-group-item-warning.active:focus,
button.list-group-item-warning.active:focus {
  color: #fff;
  background-color: #8a6d3b;
  border-color: #8a6d3b;
}
.list-group-item-danger {
  color: #a94442;
  background-color: #f2dede;
}
a.list-group-item-danger,
button.list-group-item-danger {
  color: #a94442;
}
a.list-group-item-danger .list-group-item-heading,
button.list-group-item-danger .list-group-item-heading {
  color: inherit;
}
a.list-group-item-danger:hover,
button.list-group-item-danger:hover,
a.list-group-item-danger:focus,
button.list-group-item-danger:focus {
  color: #a94442;
  background-color: #ebcccc;
}
a.list-group-item-danger.active,
button.list-group-item-danger.active,
a.list-group-item-danger.active:hover,
button.list-group-item-danger.active:hover,
a.list-group-item-danger.active:focus,
button.list-group-item-danger.active:focus {
  color: #fff;
  background-color: #a94442;
  border-color: #a94442;
}
.list-group-item-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.list-group-item-text {
  margin-bottom: 0;
  line-height: 1.3;
}
.panel {
  margin-bottom: 18px;
  background-color: #fff;
  border: 1px solid transparent;
  border-radius: 2px;
  -webkit-box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
}
.panel-body {
  padding: 15px;
}
.panel-heading {
  padding: 10px 15px;
  border-bottom: 1px solid transparent;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel-heading > .dropdown .dropdown-toggle {
  color: inherit;
}
.panel-title {
  margin-top: 0;
  margin-bottom: 0;
  font-size: 15px;
  color: inherit;
}
.panel-title > a,
.panel-title > small,
.panel-title > .small,
.panel-title > small > a,
.panel-title > .small > a {
  color: inherit;
}
.panel-footer {
  padding: 10px 15px;
  background-color: #f5f5f5;
  border-top: 1px solid #ddd;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .list-group,
.panel > .panel-collapse > .list-group {
  margin-bottom: 0;
}
.panel > .list-group .list-group-item,
.panel > .panel-collapse > .list-group .list-group-item {
  border-width: 1px 0;
  border-radius: 0;
}
.panel > .list-group:first-child .list-group-item:first-child,
.panel > .panel-collapse > .list-group:first-child .list-group-item:first-child {
  border-top: 0;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .list-group:last-child .list-group-item:last-child,
.panel > .panel-collapse > .list-group:last-child .list-group-item:last-child {
  border-bottom: 0;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .panel-heading + .panel-collapse > .list-group .list-group-item:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.panel-heading + .list-group .list-group-item:first-child {
  border-top-width: 0;
}
.list-group + .panel-footer {
  border-top-width: 0;
}
.panel > .table,
.panel > .table-responsive > .table,
.panel > .panel-collapse > .table {
  margin-bottom: 0;
}
.panel > .table caption,
.panel > .table-responsive > .table caption,
.panel > .panel-collapse > .table caption {
  padding-left: 15px;
  padding-right: 15px;
}
.panel > .table:first-child,
.panel > .table-responsive:first-child > .table:first-child {
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child {
  border-top-left-radius: 1px;
  border-top-right-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:first-child {
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:last-child {
  border-top-right-radius: 1px;
}
.panel > .table:last-child,
.panel > .table-responsive:last-child > .table:last-child {
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child {
  border-bottom-left-radius: 1px;
  border-bottom-right-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:first-child {
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:last-child {
  border-bottom-right-radius: 1px;
}
.panel > .panel-body + .table,
.panel > .panel-body + .table-responsive,
.panel > .table + .panel-body,
.panel > .table-responsive + .panel-body {
  border-top: 1px solid #ddd;
}
.panel > .table > tbody:first-child > tr:first-child th,
.panel > .table > tbody:first-child > tr:first-child td {
  border-top: 0;
}
.panel > .table-bordered,
.panel > .table-responsive > .table-bordered {
  border: 0;
}
.panel > .table-bordered > thead > tr > th:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:first-child,
.panel > .table-bordered > tbody > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:first-child,
.panel > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-bordered > thead > tr > td:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:first-child,
.panel > .table-bordered > tbody > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:first-child,
.panel > .table-bordered > tfoot > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:first-child {
  border-left: 0;
}
.panel > .table-bordered > thead > tr > th:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:last-child,
.panel > .table-bordered > tbody > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:last-child,
.panel > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-bordered > thead > tr > td:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:last-child,
.panel > .table-bordered > tbody > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:last-child,
.panel > .table-bordered > tfoot > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:last-child {
  border-right: 0;
}
.panel > .table-bordered > thead > tr:first-child > td,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > td,
.panel > .table-bordered > tbody > tr:first-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > td,
.panel > .table-bordered > thead > tr:first-child > th,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > th,
.panel > .table-bordered > tbody > tr:first-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > th {
  border-bottom: 0;
}
.panel > .table-bordered > tbody > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > td,
.panel > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-bordered > tbody > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > th,
.panel > .table-bordered > tfoot > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > th {
  border-bottom: 0;
}
.panel > .table-responsive {
  border: 0;
  margin-bottom: 0;
}
.panel-group {
  margin-bottom: 18px;
}
.panel-group .panel {
  margin-bottom: 0;
  border-radius: 2px;
}
.panel-group .panel + .panel {
  margin-top: 5px;
}
.panel-group .panel-heading {
  border-bottom: 0;
}
.panel-group .panel-heading + .panel-collapse > .panel-body,
.panel-group .panel-heading + .panel-collapse > .list-group {
  border-top: 1px solid #ddd;
}
.panel-group .panel-footer {
  border-top: 0;
}
.panel-group .panel-footer + .panel-collapse .panel-body {
  border-bottom: 1px solid #ddd;
}
.panel-default {
  border-color: #ddd;
}
.panel-default > .panel-heading {
  color: #333333;
  background-color: #f5f5f5;
  border-color: #ddd;
}
.panel-default > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ddd;
}
.panel-default > .panel-heading .badge {
  color: #f5f5f5;
  background-color: #333333;
}
.panel-default > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ddd;
}
.panel-primary {
  border-color: #337ab7;
}
.panel-primary > .panel-heading {
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.panel-primary > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #337ab7;
}
.panel-primary > .panel-heading .badge {
  color: #337ab7;
  background-color: #fff;
}
.panel-primary > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #337ab7;
}
.panel-success {
  border-color: #d6e9c6;
}
.panel-success > .panel-heading {
  color: #3c763d;
  background-color: #dff0d8;
  border-color: #d6e9c6;
}
.panel-success > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #d6e9c6;
}
.panel-success > .panel-heading .badge {
  color: #dff0d8;
  background-color: #3c763d;
}
.panel-success > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #d6e9c6;
}
.panel-info {
  border-color: #bce8f1;
}
.panel-info > .panel-heading {
  color: #31708f;
  background-color: #d9edf7;
  border-color: #bce8f1;
}
.panel-info > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #bce8f1;
}
.panel-info > .panel-heading .badge {
  color: #d9edf7;
  background-color: #31708f;
}
.panel-info > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #bce8f1;
}
.panel-warning {
  border-color: #faebcc;
}
.panel-warning > .panel-heading {
  color: #8a6d3b;
  background-color: #fcf8e3;
  border-color: #faebcc;
}
.panel-warning > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #faebcc;
}
.panel-warning > .panel-heading .badge {
  color: #fcf8e3;
  background-color: #8a6d3b;
}
.panel-warning > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #faebcc;
}
.panel-danger {
  border-color: #ebccd1;
}
.panel-danger > .panel-heading {
  color: #a94442;
  background-color: #f2dede;
  border-color: #ebccd1;
}
.panel-danger > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ebccd1;
}
.panel-danger > .panel-heading .badge {
  color: #f2dede;
  background-color: #a94442;
}
.panel-danger > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ebccd1;
}
.embed-responsive {
  position: relative;
  display: block;
  height: 0;
  padding: 0;
  overflow: hidden;
}
.embed-responsive .embed-responsive-item,
.embed-responsive iframe,
.embed-responsive embed,
.embed-responsive object,
.embed-responsive video {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  height: 100%;
  width: 100%;
  border: 0;
}
.embed-responsive-16by9 {
  padding-bottom: 56.25%;
}
.embed-responsive-4by3 {
  padding-bottom: 75%;
}
.well {
  min-height: 20px;
  padding: 19px;
  margin-bottom: 20px;
  background-color: #f5f5f5;
  border: 1px solid #e3e3e3;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
}
.well blockquote {
  border-color: #ddd;
  border-color: rgba(0, 0, 0, 0.15);
}
.well-lg {
  padding: 24px;
  border-radius: 3px;
}
.well-sm {
  padding: 9px;
  border-radius: 1px;
}
.close {
  float: right;
  font-size: 19.5px;
  font-weight: bold;
  line-height: 1;
  color: #000;
  text-shadow: 0 1px 0 #fff;
  opacity: 0.2;
  filter: alpha(opacity=20);
}
.close:hover,
.close:focus {
  color: #000;
  text-decoration: none;
  cursor: pointer;
  opacity: 0.5;
  filter: alpha(opacity=50);
}
button.close {
  padding: 0;
  cursor: pointer;
  background: transparent;
  border: 0;
  -webkit-appearance: none;
}
.modal-open {
  overflow: hidden;
}
.modal {
  display: none;
  overflow: hidden;
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1050;
  -webkit-overflow-scrolling: touch;
  outline: 0;
}
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, -25%);
  -ms-transform: translate(0, -25%);
  -o-transform: translate(0, -25%);
  transform: translate(0, -25%);
  -webkit-transition: -webkit-transform 0.3s ease-out;
  -moz-transition: -moz-transform 0.3s ease-out;
  -o-transition: -o-transform 0.3s ease-out;
  transition: transform 0.3s ease-out;
}
.modal.in .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
.modal-open .modal {
  overflow-x: hidden;
  overflow-y: auto;
}
.modal-dialog {
  position: relative;
  width: auto;
  margin: 10px;
}
.modal-content {
  position: relative;
  background-color: #fff;
  border: 1px solid #999;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  background-clip: padding-box;
  outline: 0;
}
.modal-backdrop {
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1040;
  background-color: #000;
}
.modal-backdrop.fade {
  opacity: 0;
  filter: alpha(opacity=0);
}
.modal-backdrop.in {
  opacity: 0.5;
  filter: alpha(opacity=50);
}
.modal-header {
  padding: 15px;
  border-bottom: 1px solid #e5e5e5;
}
.modal-header .close {
  margin-top: -2px;
}
.modal-title {
  margin: 0;
  line-height: 1.42857143;
}
.modal-body {
  position: relative;
  padding: 15px;
}
.modal-footer {
  padding: 15px;
  text-align: right;
  border-top: 1px solid #e5e5e5;
}
.modal-footer .btn + .btn {
  margin-left: 5px;
  margin-bottom: 0;
}
.modal-footer .btn-group .btn + .btn {
  margin-left: -1px;
}
.modal-footer .btn-block + .btn-block {
  margin-left: 0;
}
.modal-scrollbar-measure {
  position: absolute;
  top: -9999px;
  width: 50px;
  height: 50px;
  overflow: scroll;
}
@media (min-width: 768px) {
  .modal-dialog {
    width: 600px;
    margin: 30px auto;
  }
  .modal-content {
    -webkit-box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
  }
  .modal-sm {
    width: 300px;
  }
}
@media (min-width: 992px) {
  .modal-lg {
    width: 900px;
  }
}
.tooltip {
  position: absolute;
  z-index: 1070;
  display: block;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 12px;
  opacity: 0;
  filter: alpha(opacity=0);
}
.tooltip.in {
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.tooltip.top {
  margin-top: -3px;
  padding: 5px 0;
}
.tooltip.right {
  margin-left: 3px;
  padding: 0 5px;
}
.tooltip.bottom {
  margin-top: 3px;
  padding: 5px 0;
}
.tooltip.left {
  margin-left: -3px;
  padding: 0 5px;
}
.tooltip-inner {
  max-width: 200px;
  padding: 3px 8px;
  color: #fff;
  text-align: center;
  background-color: #000;
  border-radius: 2px;
}
.tooltip-arrow {
  position: absolute;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.tooltip.top .tooltip-arrow {
  bottom: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-left .tooltip-arrow {
  bottom: 0;
  right: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-right .tooltip-arrow {
  bottom: 0;
  left: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.right .tooltip-arrow {
  top: 50%;
  left: 0;
  margin-top: -5px;
  border-width: 5px 5px 5px 0;
  border-right-color: #000;
}
.tooltip.left .tooltip-arrow {
  top: 50%;
  right: 0;
  margin-top: -5px;
  border-width: 5px 0 5px 5px;
  border-left-color: #000;
}
.tooltip.bottom .tooltip-arrow {
  top: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-left .tooltip-arrow {
  top: 0;
  right: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-right .tooltip-arrow {
  top: 0;
  left: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.popover {
  position: absolute;
  top: 0;
  left: 0;
  z-index: 1060;
  display: none;
  max-width: 276px;
  padding: 1px;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 13px;
  background-color: #fff;
  background-clip: padding-box;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
  box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
}
.popover.top {
  margin-top: -10px;
}
.popover.right {
  margin-left: 10px;
}
.popover.bottom {
  margin-top: 10px;
}
.popover.left {
  margin-left: -10px;
}
.popover-title {
  margin: 0;
  padding: 8px 14px;
  font-size: 13px;
  background-color: #f7f7f7;
  border-bottom: 1px solid #ebebeb;
  border-radius: 2px 2px 0 0;
}
.popover-content {
  padding: 9px 14px;
}
.popover > .arrow,
.popover > .arrow:after {
  position: absolute;
  display: block;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.popover > .arrow {
  border-width: 11px;
}
.popover > .arrow:after {
  border-width: 10px;
  content: "";
}
.popover.top > .arrow {
  left: 50%;
  margin-left: -11px;
  border-bottom-width: 0;
  border-top-color: #999999;
  border-top-color: rgba(0, 0, 0, 0.25);
  bottom: -11px;
}
.popover.top > .arrow:after {
  content: " ";
  bottom: 1px;
  margin-left: -10px;
  border-bottom-width: 0;
  border-top-color: #fff;
}
.popover.right > .arrow {
  top: 50%;
  left: -11px;
  margin-top: -11px;
  border-left-width: 0;
  border-right-color: #999999;
  border-right-color: rgba(0, 0, 0, 0.25);
}
.popover.right > .arrow:after {
  content: " ";
  left: 1px;
  bottom: -10px;
  border-left-width: 0;
  border-right-color: #fff;
}
.popover.bottom > .arrow {
  left: 50%;
  margin-left: -11px;
  border-top-width: 0;
  border-bottom-color: #999999;
  border-bottom-color: rgba(0, 0, 0, 0.25);
  top: -11px;
}
.popover.bottom > .arrow:after {
  content: " ";
  top: 1px;
  margin-left: -10px;
  border-top-width: 0;
  border-bottom-color: #fff;
}
.popover.left > .arrow {
  top: 50%;
  right: -11px;
  margin-top: -11px;
  border-right-width: 0;
  border-left-color: #999999;
  border-left-color: rgba(0, 0, 0, 0.25);
}
.popover.left > .arrow:after {
  content: " ";
  right: 1px;
  border-right-width: 0;
  border-left-color: #fff;
  bottom: -10px;
}
.carousel {
  position: relative;
}
.carousel-inner {
  position: relative;
  overflow: hidden;
  width: 100%;
}
.carousel-inner > .item {
  display: none;
  position: relative;
  -webkit-transition: 0.6s ease-in-out left;
  -o-transition: 0.6s ease-in-out left;
  transition: 0.6s ease-in-out left;
}
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  line-height: 1;
}
@media all and (transform-3d), (-webkit-transform-3d) {
  .carousel-inner > .item {
    -webkit-transition: -webkit-transform 0.6s ease-in-out;
    -moz-transition: -moz-transform 0.6s ease-in-out;
    -o-transition: -o-transform 0.6s ease-in-out;
    transition: transform 0.6s ease-in-out;
    -webkit-backface-visibility: hidden;
    -moz-backface-visibility: hidden;
    backface-visibility: hidden;
    -webkit-perspective: 1000px;
    -moz-perspective: 1000px;
    perspective: 1000px;
  }
  .carousel-inner > .item.next,
  .carousel-inner > .item.active.right {
    -webkit-transform: translate3d(100%, 0, 0);
    transform: translate3d(100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.prev,
  .carousel-inner > .item.active.left {
    -webkit-transform: translate3d(-100%, 0, 0);
    transform: translate3d(-100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.next.left,
  .carousel-inner > .item.prev.right,
  .carousel-inner > .item.active {
    -webkit-transform: translate3d(0, 0, 0);
    transform: translate3d(0, 0, 0);
    left: 0;
  }
}
.carousel-inner > .active,
.carousel-inner > .next,
.carousel-inner > .prev {
  display: block;
}
.carousel-inner > .active {
  left: 0;
}
.carousel-inner > .next,
.carousel-inner > .prev {
  position: absolute;
  top: 0;
  width: 100%;
}
.carousel-inner > .next {
  left: 100%;
}
.carousel-inner > .prev {
  left: -100%;
}
.carousel-inner > .next.left,
.carousel-inner > .prev.right {
  left: 0;
}
.carousel-inner > .active.left {
  left: -100%;
}
.carousel-inner > .active.right {
  left: 100%;
}
.carousel-control {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  width: 15%;
  opacity: 0.5;
  filter: alpha(opacity=50);
  font-size: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
  background-color: rgba(0, 0, 0, 0);
}
.carousel-control.left {
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#80000000', endColorstr='#00000000', GradientType=1);
}
.carousel-control.right {
  left: auto;
  right: 0;
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#00000000', endColorstr='#80000000', GradientType=1);
}
.carousel-control:hover,
.carousel-control:focus {
  outline: 0;
  color: #fff;
  text-decoration: none;
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.carousel-control .icon-prev,
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-left,
.carousel-control .glyphicon-chevron-right {
  position: absolute;
  top: 50%;
  margin-top: -10px;
  z-index: 5;
  display: inline-block;
}
.carousel-control .icon-prev,
.carousel-control .glyphicon-chevron-left {
  left: 50%;
  margin-left: -10px;
}
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-right {
  right: 50%;
  margin-right: -10px;
}
.carousel-control .icon-prev,
.carousel-control .icon-next {
  width: 20px;
  height: 20px;
  line-height: 1;
  font-family: serif;
}
.carousel-control .icon-prev:before {
  content: '\2039';
}
.carousel-control .icon-next:before {
  content: '\203a';
}
.carousel-indicators {
  position: absolute;
  bottom: 10px;
  left: 50%;
  z-index: 15;
  width: 60%;
  margin-left: -30%;
  padding-left: 0;
  list-style: none;
  text-align: center;
}
.carousel-indicators li {
  display: inline-block;
  width: 10px;
  height: 10px;
  margin: 1px;
  text-indent: -999px;
  border: 1px solid #fff;
  border-radius: 10px;
  cursor: pointer;
  background-color: #000 \9;
  background-color: rgba(0, 0, 0, 0);
}
.carousel-indicators .active {
  margin: 0;
  width: 12px;
  height: 12px;
  background-color: #fff;
}
.carousel-caption {
  position: absolute;
  left: 15%;
  right: 15%;
  bottom: 20px;
  z-index: 10;
  padding-top: 20px;
  padding-bottom: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
}
.carousel-caption .btn {
  text-shadow: none;
}
@media screen and (min-width: 768px) {
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-prev,
  .carousel-control .icon-next {
    width: 30px;
    height: 30px;
    margin-top: -10px;
    font-size: 30px;
  }
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .icon-prev {
    margin-left: -10px;
  }
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-next {
    margin-right: -10px;
  }
  .carousel-caption {
    left: 20%;
    right: 20%;
    padding-bottom: 30px;
  }
  .carousel-indicators {
    bottom: 20px;
  }
}
.clearfix:before,
.clearfix:after,
.dl-horizontal dd:before,
.dl-horizontal dd:after,
.container:before,
.container:after,
.container-fluid:before,
.container-fluid:after,
.row:before,
.row:after,
.form-horizontal .form-group:before,
.form-horizontal .form-group:after,
.btn-toolbar:before,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:before,
.btn-group-vertical > .btn-group:after,
.nav:before,
.nav:after,
.navbar:before,
.navbar:after,
.navbar-header:before,
.navbar-header:after,
.navbar-collapse:before,
.navbar-collapse:after,
.pager:before,
.pager:after,
.panel-body:before,
.panel-body:after,
.modal-header:before,
.modal-header:after,
.modal-footer:before,
.modal-footer:after,
.item_buttons:before,
.item_buttons:after {
  content: " ";
  display: table;
}
.clearfix:after,
.dl-horizontal dd:after,
.container:after,
.container-fluid:after,
.row:after,
.form-horizontal .form-group:after,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:after,
.nav:after,
.navbar:after,
.navbar-header:after,
.navbar-collapse:after,
.pager:after,
.panel-body:after,
.modal-header:after,
.modal-footer:after,
.item_buttons:after {
  clear: both;
}
.center-block {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.pull-right {
  float: right !important;
}
.pull-left {
  float: left !important;
}
.hide {
  display: none !important;
}
.show {
  display: block !important;
}
.invisible {
  visibility: hidden;
}
.text-hide {
  font: 0/0 a;
  color: transparent;
  text-shadow: none;
  background-color: transparent;
  border: 0;
}
.hidden {
  display: none !important;
}
.affix {
  position: fixed;
}
@-ms-viewport {
  width: device-width;
}
.visible-xs,
.visible-sm,
.visible-md,
.visible-lg {
  display: none !important;
}
.visible-xs-block,
.visible-xs-inline,
.visible-xs-inline-block,
.visible-sm-block,
.visible-sm-inline,
.visible-sm-inline-block,
.visible-md-block,
.visible-md-inline,
.visible-md-inline-block,
.visible-lg-block,
.visible-lg-inline,
.visible-lg-inline-block {
  display: none !important;
}
@media (max-width: 767px) {
  .visible-xs {
    display: block !important;
  }
  table.visible-xs {
    display: table !important;
  }
  tr.visible-xs {
    display: table-row !important;
  }
  th.visible-xs,
  td.visible-xs {
    display: table-cell !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-block {
    display: block !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline {
    display: inline !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm {
    display: block !important;
  }
  table.visible-sm {
    display: table !important;
  }
  tr.visible-sm {
    display: table-row !important;
  }
  th.visible-sm,
  td.visible-sm {
    display: table-cell !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-block {
    display: block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline {
    display: inline !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md {
    display: block !important;
  }
  table.visible-md {
    display: table !important;
  }
  tr.visible-md {
    display: table-row !important;
  }
  th.visible-md,
  td.visible-md {
    display: table-cell !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-block {
    display: block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline {
    display: inline !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg {
    display: block !important;
  }
  table.visible-lg {
    display: table !important;
  }
  tr.visible-lg {
    display: table-row !important;
  }
  th.visible-lg,
  td.visible-lg {
    display: table-cell !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-block {
    display: block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline {
    display: inline !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline-block {
    display: inline-block !important;
  }
}
@media (max-width: 767px) {
  .hidden-xs {
    display: none !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .hidden-sm {
    display: none !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .hidden-md {
    display: none !important;
  }
}
@media (min-width: 1200px) {
  .hidden-lg {
    display: none !important;
  }
}
.visible-print {
  display: none !important;
}
@media print {
  .visible-print {
    display: block !important;
  }
  table.visible-print {
    display: table !important;
  }
  tr.visible-print {
    display: table-row !important;
  }
  th.visible-print,
  td.visible-print {
    display: table-cell !important;
  }
}
.visible-print-block {
  display: none !important;
}
@media print {
  .visible-print-block {
    display: block !important;
  }
}
.visible-print-inline {
  display: none !important;
}
@media print {
  .visible-print-inline {
    display: inline !important;
  }
}
.visible-print-inline-block {
  display: none !important;
}
@media print {
  .visible-print-inline-block {
    display: inline-block !important;
  }
}
@media print {
  .hidden-print {
    display: none !important;
  }
}
/*!
*
* Font Awesome
*
*/
/*!
 *  Font Awesome 4.7.0 by @davegandy - http://fontawesome.io - @fontawesome
 *  License - http://fontawesome.io/license (Font: SIL OFL 1.1, CSS: MIT License)
 */
/* FONT PATH
 * -------------------------- */
@font-face {
  font-family: 'FontAwesome';
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?v=4.7.0');
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?#iefix&v=4.7.0') format('embedded-opentype'), url('../components/font-awesome/fonts/fontawesome-webfont.woff2?v=4.7.0') format('woff2'), url('../components/font-awesome/fonts/fontawesome-webfont.woff?v=4.7.0') format('woff'), url('../components/font-awesome/fonts/fontawesome-webfont.ttf?v=4.7.0') format('truetype'), url('../components/font-awesome/fonts/fontawesome-webfont.svg?v=4.7.0#fontawesomeregular') format('svg');
  font-weight: normal;
  font-style: normal;
}
.fa {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}
/* makes the font 33% larger relative to the icon container */
.fa-lg {
  font-size: 1.33333333em;
  line-height: 0.75em;
  vertical-align: -15%;
}
.fa-2x {
  font-size: 2em;
}
.fa-3x {
  font-size: 3em;
}
.fa-4x {
  font-size: 4em;
}
.fa-5x {
  font-size: 5em;
}
.fa-fw {
  width: 1.28571429em;
  text-align: center;
}
.fa-ul {
  padding-left: 0;
  margin-left: 2.14285714em;
  list-style-type: none;
}
.fa-ul > li {
  position: relative;
}
.fa-li {
  position: absolute;
  left: -2.14285714em;
  width: 2.14285714em;
  top: 0.14285714em;
  text-align: center;
}
.fa-li.fa-lg {
  left: -1.85714286em;
}
.fa-border {
  padding: .2em .25em .15em;
  border: solid 0.08em #eee;
  border-radius: .1em;
}
.fa-pull-left {
  float: left;
}
.fa-pull-right {
  float: right;
}
.fa.fa-pull-left {
  margin-right: .3em;
}
.fa.fa-pull-right {
  margin-left: .3em;
}
/* Deprecated as of 4.4.0 */
.pull-right {
  float: right;
}
.pull-left {
  float: left;
}
.fa.pull-left {
  margin-right: .3em;
}
.fa.pull-right {
  margin-left: .3em;
}
.fa-spin {
  -webkit-animation: fa-spin 2s infinite linear;
  animation: fa-spin 2s infinite linear;
}
.fa-pulse {
  -webkit-animation: fa-spin 1s infinite steps(8);
  animation: fa-spin 1s infinite steps(8);
}
@-webkit-keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
@keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
.fa-rotate-90 {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=1)";
  -webkit-transform: rotate(90deg);
  -ms-transform: rotate(90deg);
  transform: rotate(90deg);
}
.fa-rotate-180 {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=2)";
  -webkit-transform: rotate(180deg);
  -ms-transform: rotate(180deg);
  transform: rotate(180deg);
}
.fa-rotate-270 {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=3)";
  -webkit-transform: rotate(270deg);
  -ms-transform: rotate(270deg);
  transform: rotate(270deg);
}
.fa-flip-horizontal {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=0, mirror=1)";
  -webkit-transform: scale(-1, 1);
  -ms-transform: scale(-1, 1);
  transform: scale(-1, 1);
}
.fa-flip-vertical {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=2, mirror=1)";
  -webkit-transform: scale(1, -1);
  -ms-transform: scale(1, -1);
  transform: scale(1, -1);
}
:root .fa-rotate-90,
:root .fa-rotate-180,
:root .fa-rotate-270,
:root .fa-flip-horizontal,
:root .fa-flip-vertical {
  filter: none;
}
.fa-stack {
  position: relative;
  display: inline-block;
  width: 2em;
  height: 2em;
  line-height: 2em;
  vertical-align: middle;
}
.fa-stack-1x,
.fa-stack-2x {
  position: absolute;
  left: 0;
  width: 100%;
  text-align: center;
}
.fa-stack-1x {
  line-height: inherit;
}
.fa-stack-2x {
  font-size: 2em;
}
.fa-inverse {
  color: #fff;
}
/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen
   readers do not read off random characters that represent icons */
.fa-glass:before {
  content: "\f000";
}
.fa-music:before {
  content: "\f001";
}
.fa-search:before {
  content: "\f002";
}
.fa-envelope-o:before {
  content: "\f003";
}
.fa-heart:before {
  content: "\f004";
}
.fa-star:before {
  content: "\f005";
}
.fa-star-o:before {
  content: "\f006";
}
.fa-user:before {
  content: "\f007";
}
.fa-film:before {
  content: "\f008";
}
.fa-th-large:before {
  content: "\f009";
}
.fa-th:before {
  content: "\f00a";
}
.fa-th-list:before {
  content: "\f00b";
}
.fa-check:before {
  content: "\f00c";
}
.fa-remove:before,
.fa-close:before,
.fa-times:before {
  content: "\f00d";
}
.fa-search-plus:before {
  content: "\f00e";
}
.fa-search-minus:before {
  content: "\f010";
}
.fa-power-off:before {
  content: "\f011";
}
.fa-signal:before {
  content: "\f012";
}
.fa-gear:before,
.fa-cog:before {
  content: "\f013";
}
.fa-trash-o:before {
  content: "\f014";
}
.fa-home:before {
  content: "\f015";
}
.fa-file-o:before {
  content: "\f016";
}
.fa-clock-o:before {
  content: "\f017";
}
.fa-road:before {
  content: "\f018";
}
.fa-download:before {
  content: "\f019";
}
.fa-arrow-circle-o-down:before {
  content: "\f01a";
}
.fa-arrow-circle-o-up:before {
  content: "\f01b";
}
.fa-inbox:before {
  content: "\f01c";
}
.fa-play-circle-o:before {
  content: "\f01d";
}
.fa-rotate-right:before,
.fa-repeat:before {
  content: "\f01e";
}
.fa-refresh:before {
  content: "\f021";
}
.fa-list-alt:before {
  content: "\f022";
}
.fa-lock:before {
  content: "\f023";
}
.fa-flag:before {
  content: "\f024";
}
.fa-headphones:before {
  content: "\f025";
}
.fa-volume-off:before {
  content: "\f026";
}
.fa-volume-down:before {
  content: "\f027";
}
.fa-volume-up:before {
  content: "\f028";
}
.fa-qrcode:before {
  content: "\f029";
}
.fa-barcode:before {
  content: "\f02a";
}
.fa-tag:before {
  content: "\f02b";
}
.fa-tags:before {
  content: "\f02c";
}
.fa-book:before {
  content: "\f02d";
}
.fa-bookmark:before {
  content: "\f02e";
}
.fa-print:before {
  content: "\f02f";
}
.fa-camera:before {
  content: "\f030";
}
.fa-font:before {
  content: "\f031";
}
.fa-bold:before {
  content: "\f032";
}
.fa-italic:before {
  content: "\f033";
}
.fa-text-height:before {
  content: "\f034";
}
.fa-text-width:before {
  content: "\f035";
}
.fa-align-left:before {
  content: "\f036";
}
.fa-align-center:before {
  content: "\f037";
}
.fa-align-right:before {
  content: "\f038";
}
.fa-align-justify:before {
  content: "\f039";
}
.fa-list:before {
  content: "\f03a";
}
.fa-dedent:before,
.fa-outdent:before {
  content: "\f03b";
}
.fa-indent:before {
  content: "\f03c";
}
.fa-video-camera:before {
  content: "\f03d";
}
.fa-photo:before,
.fa-image:before,
.fa-picture-o:before {
  content: "\f03e";
}
.fa-pencil:before {
  content: "\f040";
}
.fa-map-marker:before {
  content: "\f041";
}
.fa-adjust:before {
  content: "\f042";
}
.fa-tint:before {
  content: "\f043";
}
.fa-edit:before,
.fa-pencil-square-o:before {
  content: "\f044";
}
.fa-share-square-o:before {
  content: "\f045";
}
.fa-check-square-o:before {
  content: "\f046";
}
.fa-arrows:before {
  content: "\f047";
}
.fa-step-backward:before {
  content: "\f048";
}
.fa-fast-backward:before {
  content: "\f049";
}
.fa-backward:before {
  content: "\f04a";
}
.fa-play:before {
  content: "\f04b";
}
.fa-pause:before {
  content: "\f04c";
}
.fa-stop:before {
  content: "\f04d";
}
.fa-forward:before {
  content: "\f04e";
}
.fa-fast-forward:before {
  content: "\f050";
}
.fa-step-forward:before {
  content: "\f051";
}
.fa-eject:before {
  content: "\f052";
}
.fa-chevron-left:before {
  content: "\f053";
}
.fa-chevron-right:before {
  content: "\f054";
}
.fa-plus-circle:before {
  content: "\f055";
}
.fa-minus-circle:before {
  content: "\f056";
}
.fa-times-circle:before {
  content: "\f057";
}
.fa-check-circle:before {
  content: "\f058";
}
.fa-question-circle:before {
  content: "\f059";
}
.fa-info-circle:before {
  content: "\f05a";
}
.fa-crosshairs:before {
  content: "\f05b";
}
.fa-times-circle-o:before {
  content: "\f05c";
}
.fa-check-circle-o:before {
  content: "\f05d";
}
.fa-ban:before {
  content: "\f05e";
}
.fa-arrow-left:before {
  content: "\f060";
}
.fa-arrow-right:before {
  content: "\f061";
}
.fa-arrow-up:before {
  content: "\f062";
}
.fa-arrow-down:before {
  content: "\f063";
}
.fa-mail-forward:before,
.fa-share:before {
  content: "\f064";
}
.fa-expand:before {
  content: "\f065";
}
.fa-compress:before {
  content: "\f066";
}
.fa-plus:before {
  content: "\f067";
}
.fa-minus:before {
  content: "\f068";
}
.fa-asterisk:before {
  content: "\f069";
}
.fa-exclamation-circle:before {
  content: "\f06a";
}
.fa-gift:before {
  content: "\f06b";
}
.fa-leaf:before {
  content: "\f06c";
}
.fa-fire:before {
  content: "\f06d";
}
.fa-eye:before {
  content: "\f06e";
}
.fa-eye-slash:before {
  content: "\f070";
}
.fa-warning:before,
.fa-exclamation-triangle:before {
  content: "\f071";
}
.fa-plane:before {
  content: "\f072";
}
.fa-calendar:before {
  content: "\f073";
}
.fa-random:before {
  content: "\f074";
}
.fa-comment:before {
  content: "\f075";
}
.fa-magnet:before {
  content: "\f076";
}
.fa-chevron-up:before {
  content: "\f077";
}
.fa-chevron-down:before {
  content: "\f078";
}
.fa-retweet:before {
  content: "\f079";
}
.fa-shopping-cart:before {
  content: "\f07a";
}
.fa-folder:before {
  content: "\f07b";
}
.fa-folder-open:before {
  content: "\f07c";
}
.fa-arrows-v:before {
  content: "\f07d";
}
.fa-arrows-h:before {
  content: "\f07e";
}
.fa-bar-chart-o:before,
.fa-bar-chart:before {
  content: "\f080";
}
.fa-twitter-square:before {
  content: "\f081";
}
.fa-facebook-square:before {
  content: "\f082";
}
.fa-camera-retro:before {
  content: "\f083";
}
.fa-key:before {
  content: "\f084";
}
.fa-gears:before,
.fa-cogs:before {
  content: "\f085";
}
.fa-comments:before {
  content: "\f086";
}
.fa-thumbs-o-up:before {
  content: "\f087";
}
.fa-thumbs-o-down:before {
  content: "\f088";
}
.fa-star-half:before {
  content: "\f089";
}
.fa-heart-o:before {
  content: "\f08a";
}
.fa-sign-out:before {
  content: "\f08b";
}
.fa-linkedin-square:before {
  content: "\f08c";
}
.fa-thumb-tack:before {
  content: "\f08d";
}
.fa-external-link:before {
  content: "\f08e";
}
.fa-sign-in:before {
  content: "\f090";
}
.fa-trophy:before {
  content: "\f091";
}
.fa-github-square:before {
  content: "\f092";
}
.fa-upload:before {
  content: "\f093";
}
.fa-lemon-o:before {
  content: "\f094";
}
.fa-phone:before {
  content: "\f095";
}
.fa-square-o:before {
  content: "\f096";
}
.fa-bookmark-o:before {
  content: "\f097";
}
.fa-phone-square:before {
  content: "\f098";
}
.fa-twitter:before {
  content: "\f099";
}
.fa-facebook-f:before,
.fa-facebook:before {
  content: "\f09a";
}
.fa-github:before {
  content: "\f09b";
}
.fa-unlock:before {
  content: "\f09c";
}
.fa-credit-card:before {
  content: "\f09d";
}
.fa-feed:before,
.fa-rss:before {
  content: "\f09e";
}
.fa-hdd-o:before {
  content: "\f0a0";
}
.fa-bullhorn:before {
  content: "\f0a1";
}
.fa-bell:before {
  content: "\f0f3";
}
.fa-certificate:before {
  content: "\f0a3";
}
.fa-hand-o-right:before {
  content: "\f0a4";
}
.fa-hand-o-left:before {
  content: "\f0a5";
}
.fa-hand-o-up:before {
  content: "\f0a6";
}
.fa-hand-o-down:before {
  content: "\f0a7";
}
.fa-arrow-circle-left:before {
  content: "\f0a8";
}
.fa-arrow-circle-right:before {
  content: "\f0a9";
}
.fa-arrow-circle-up:before {
  content: "\f0aa";
}
.fa-arrow-circle-down:before {
  content: "\f0ab";
}
.fa-globe:before {
  content: "\f0ac";
}
.fa-wrench:before {
  content: "\f0ad";
}
.fa-tasks:before {
  content: "\f0ae";
}
.fa-filter:before {
  content: "\f0b0";
}
.fa-briefcase:before {
  content: "\f0b1";
}
.fa-arrows-alt:before {
  content: "\f0b2";
}
.fa-group:before,
.fa-users:before {
  content: "\f0c0";
}
.fa-chain:before,
.fa-link:before {
  content: "\f0c1";
}
.fa-cloud:before {
  content: "\f0c2";
}
.fa-flask:before {
  content: "\f0c3";
}
.fa-cut:before,
.fa-scissors:before {
  content: "\f0c4";
}
.fa-copy:before,
.fa-files-o:before {
  content: "\f0c5";
}
.fa-paperclip:before {
  content: "\f0c6";
}
.fa-save:before,
.fa-floppy-o:before {
  content: "\f0c7";
}
.fa-square:before {
  content: "\f0c8";
}
.fa-navicon:before,
.fa-reorder:before,
.fa-bars:before {
  content: "\f0c9";
}
.fa-list-ul:before {
  content: "\f0ca";
}
.fa-list-ol:before {
  content: "\f0cb";
}
.fa-strikethrough:before {
  content: "\f0cc";
}
.fa-underline:before {
  content: "\f0cd";
}
.fa-table:before {
  content: "\f0ce";
}
.fa-magic:before {
  content: "\f0d0";
}
.fa-truck:before {
  content: "\f0d1";
}
.fa-pinterest:before {
  content: "\f0d2";
}
.fa-pinterest-square:before {
  content: "\f0d3";
}
.fa-google-plus-square:before {
  content: "\f0d4";
}
.fa-google-plus:before {
  content: "\f0d5";
}
.fa-money:before {
  content: "\f0d6";
}
.fa-caret-down:before {
  content: "\f0d7";
}
.fa-caret-up:before {
  content: "\f0d8";
}
.fa-caret-left:before {
  content: "\f0d9";
}
.fa-caret-right:before {
  content: "\f0da";
}
.fa-columns:before {
  content: "\f0db";
}
.fa-unsorted:before,
.fa-sort:before {
  content: "\f0dc";
}
.fa-sort-down:before,
.fa-sort-desc:before {
  content: "\f0dd";
}
.fa-sort-up:before,
.fa-sort-asc:before {
  content: "\f0de";
}
.fa-envelope:before {
  content: "\f0e0";
}
.fa-linkedin:before {
  content: "\f0e1";
}
.fa-rotate-left:before,
.fa-undo:before {
  content: "\f0e2";
}
.fa-legal:before,
.fa-gavel:before {
  content: "\f0e3";
}
.fa-dashboard:before,
.fa-tachometer:before {
  content: "\f0e4";
}
.fa-comment-o:before {
  content: "\f0e5";
}
.fa-comments-o:before {
  content: "\f0e6";
}
.fa-flash:before,
.fa-bolt:before {
  content: "\f0e7";
}
.fa-sitemap:before {
  content: "\f0e8";
}
.fa-umbrella:before {
  content: "\f0e9";
}
.fa-paste:before,
.fa-clipboard:before {
  content: "\f0ea";
}
.fa-lightbulb-o:before {
  content: "\f0eb";
}
.fa-exchange:before {
  content: "\f0ec";
}
.fa-cloud-download:before {
  content: "\f0ed";
}
.fa-cloud-upload:before {
  content: "\f0ee";
}
.fa-user-md:before {
  content: "\f0f0";
}
.fa-stethoscope:before {
  content: "\f0f1";
}
.fa-suitcase:before {
  content: "\f0f2";
}
.fa-bell-o:before {
  content: "\f0a2";
}
.fa-coffee:before {
  content: "\f0f4";
}
.fa-cutlery:before {
  content: "\f0f5";
}
.fa-file-text-o:before {
  content: "\f0f6";
}
.fa-building-o:before {
  content: "\f0f7";
}
.fa-hospital-o:before {
  content: "\f0f8";
}
.fa-ambulance:before {
  content: "\f0f9";
}
.fa-medkit:before {
  content: "\f0fa";
}
.fa-fighter-jet:before {
  content: "\f0fb";
}
.fa-beer:before {
  content: "\f0fc";
}
.fa-h-square:before {
  content: "\f0fd";
}
.fa-plus-square:before {
  content: "\f0fe";
}
.fa-angle-double-left:before {
  content: "\f100";
}
.fa-angle-double-right:before {
  content: "\f101";
}
.fa-angle-double-up:before {
  content: "\f102";
}
.fa-angle-double-down:before {
  content: "\f103";
}
.fa-angle-left:before {
  content: "\f104";
}
.fa-angle-right:before {
  content: "\f105";
}
.fa-angle-up:before {
  content: "\f106";
}
.fa-angle-down:before {
  content: "\f107";
}
.fa-desktop:before {
  content: "\f108";
}
.fa-laptop:before {
  content: "\f109";
}
.fa-tablet:before {
  content: "\f10a";
}
.fa-mobile-phone:before,
.fa-mobile:before {
  content: "\f10b";
}
.fa-circle-o:before {
  content: "\f10c";
}
.fa-quote-left:before {
  content: "\f10d";
}
.fa-quote-right:before {
  content: "\f10e";
}
.fa-spinner:before {
  content: "\f110";
}
.fa-circle:before {
  content: "\f111";
}
.fa-mail-reply:before,
.fa-reply:before {
  content: "\f112";
}
.fa-github-alt:before {
  content: "\f113";
}
.fa-folder-o:before {
  content: "\f114";
}
.fa-folder-open-o:before {
  content: "\f115";
}
.fa-smile-o:before {
  content: "\f118";
}
.fa-frown-o:before {
  content: "\f119";
}
.fa-meh-o:before {
  content: "\f11a";
}
.fa-gamepad:before {
  content: "\f11b";
}
.fa-keyboard-o:before {
  content: "\f11c";
}
.fa-flag-o:before {
  content: "\f11d";
}
.fa-flag-checkered:before {
  content: "\f11e";
}
.fa-terminal:before {
  content: "\f120";
}
.fa-code:before {
  content: "\f121";
}
.fa-mail-reply-all:before,
.fa-reply-all:before {
  content: "\f122";
}
.fa-star-half-empty:before,
.fa-star-half-full:before,
.fa-star-half-o:before {
  content: "\f123";
}
.fa-location-arrow:before {
  content: "\f124";
}
.fa-crop:before {
  content: "\f125";
}
.fa-code-fork:before {
  content: "\f126";
}
.fa-unlink:before,
.fa-chain-broken:before {
  content: "\f127";
}
.fa-question:before {
  content: "\f128";
}
.fa-info:before {
  content: "\f129";
}
.fa-exclamation:before {
  content: "\f12a";
}
.fa-superscript:before {
  content: "\f12b";
}
.fa-subscript:before {
  content: "\f12c";
}
.fa-eraser:before {
  content: "\f12d";
}
.fa-puzzle-piece:before {
  content: "\f12e";
}
.fa-microphone:before {
  content: "\f130";
}
.fa-microphone-slash:before {
  content: "\f131";
}
.fa-shield:before {
  content: "\f132";
}
.fa-calendar-o:before {
  content: "\f133";
}
.fa-fire-extinguisher:before {
  content: "\f134";
}
.fa-rocket:before {
  content: "\f135";
}
.fa-maxcdn:before {
  content: "\f136";
}
.fa-chevron-circle-left:before {
  content: "\f137";
}
.fa-chevron-circle-right:before {
  content: "\f138";
}
.fa-chevron-circle-up:before {
  content: "\f139";
}
.fa-chevron-circle-down:before {
  content: "\f13a";
}
.fa-html5:before {
  content: "\f13b";
}
.fa-css3:before {
  content: "\f13c";
}
.fa-anchor:before {
  content: "\f13d";
}
.fa-unlock-alt:before {
  content: "\f13e";
}
.fa-bullseye:before {
  content: "\f140";
}
.fa-ellipsis-h:before {
  content: "\f141";
}
.fa-ellipsis-v:before {
  content: "\f142";
}
.fa-rss-square:before {
  content: "\f143";
}
.fa-play-circle:before {
  content: "\f144";
}
.fa-ticket:before {
  content: "\f145";
}
.fa-minus-square:before {
  content: "\f146";
}
.fa-minus-square-o:before {
  content: "\f147";
}
.fa-level-up:before {
  content: "\f148";
}
.fa-level-down:before {
  content: "\f149";
}
.fa-check-square:before {
  content: "\f14a";
}
.fa-pencil-square:before {
  content: "\f14b";
}
.fa-external-link-square:before {
  content: "\f14c";
}
.fa-share-square:before {
  content: "\f14d";
}
.fa-compass:before {
  content: "\f14e";
}
.fa-toggle-down:before,
.fa-caret-square-o-down:before {
  content: "\f150";
}
.fa-toggle-up:before,
.fa-caret-square-o-up:before {
  content: "\f151";
}
.fa-toggle-right:before,
.fa-caret-square-o-right:before {
  content: "\f152";
}
.fa-euro:before,
.fa-eur:before {
  content: "\f153";
}
.fa-gbp:before {
  content: "\f154";
}
.fa-dollar:before,
.fa-usd:before {
  content: "\f155";
}
.fa-rupee:before,
.fa-inr:before {
  content: "\f156";
}
.fa-cny:before,
.fa-rmb:before,
.fa-yen:before,
.fa-jpy:before {
  content: "\f157";
}
.fa-ruble:before,
.fa-rouble:before,
.fa-rub:before {
  content: "\f158";
}
.fa-won:before,
.fa-krw:before {
  content: "\f159";
}
.fa-bitcoin:before,
.fa-btc:before {
  content: "\f15a";
}
.fa-file:before {
  content: "\f15b";
}
.fa-file-text:before {
  content: "\f15c";
}
.fa-sort-alpha-asc:before {
  content: "\f15d";
}
.fa-sort-alpha-desc:before {
  content: "\f15e";
}
.fa-sort-amount-asc:before {
  content: "\f160";
}
.fa-sort-amount-desc:before {
  content: "\f161";
}
.fa-sort-numeric-asc:before {
  content: "\f162";
}
.fa-sort-numeric-desc:before {
  content: "\f163";
}
.fa-thumbs-up:before {
  content: "\f164";
}
.fa-thumbs-down:before {
  content: "\f165";
}
.fa-youtube-square:before {
  content: "\f166";
}
.fa-youtube:before {
  content: "\f167";
}
.fa-xing:before {
  content: "\f168";
}
.fa-xing-square:before {
  content: "\f169";
}
.fa-youtube-play:before {
  content: "\f16a";
}
.fa-dropbox:before {
  content: "\f16b";
}
.fa-stack-overflow:before {
  content: "\f16c";
}
.fa-instagram:before {
  content: "\f16d";
}
.fa-flickr:before {
  content: "\f16e";
}
.fa-adn:before {
  content: "\f170";
}
.fa-bitbucket:before {
  content: "\f171";
}
.fa-bitbucket-square:before {
  content: "\f172";
}
.fa-tumblr:before {
  content: "\f173";
}
.fa-tumblr-square:before {
  content: "\f174";
}
.fa-long-arrow-down:before {
  content: "\f175";
}
.fa-long-arrow-up:before {
  content: "\f176";
}
.fa-long-arrow-left:before {
  content: "\f177";
}
.fa-long-arrow-right:before {
  content: "\f178";
}
.fa-apple:before {
  content: "\f179";
}
.fa-windows:before {
  content: "\f17a";
}
.fa-android:before {
  content: "\f17b";
}
.fa-linux:before {
  content: "\f17c";
}
.fa-dribbble:before {
  content: "\f17d";
}
.fa-skype:before {
  content: "\f17e";
}
.fa-foursquare:before {
  content: "\f180";
}
.fa-trello:before {
  content: "\f181";
}
.fa-female:before {
  content: "\f182";
}
.fa-male:before {
  content: "\f183";
}
.fa-gittip:before,
.fa-gratipay:before {
  content: "\f184";
}
.fa-sun-o:before {
  content: "\f185";
}
.fa-moon-o:before {
  content: "\f186";
}
.fa-archive:before {
  content: "\f187";
}
.fa-bug:before {
  content: "\f188";
}
.fa-vk:before {
  content: "\f189";
}
.fa-weibo:before {
  content: "\f18a";
}
.fa-renren:before {
  content: "\f18b";
}
.fa-pagelines:before {
  content: "\f18c";
}
.fa-stack-exchange:before {
  content: "\f18d";
}
.fa-arrow-circle-o-right:before {
  content: "\f18e";
}
.fa-arrow-circle-o-left:before {
  content: "\f190";
}
.fa-toggle-left:before,
.fa-caret-square-o-left:before {
  content: "\f191";
}
.fa-dot-circle-o:before {
  content: "\f192";
}
.fa-wheelchair:before {
  content: "\f193";
}
.fa-vimeo-square:before {
  content: "\f194";
}
.fa-turkish-lira:before,
.fa-try:before {
  content: "\f195";
}
.fa-plus-square-o:before {
  content: "\f196";
}
.fa-space-shuttle:before {
  content: "\f197";
}
.fa-slack:before {
  content: "\f198";
}
.fa-envelope-square:before {
  content: "\f199";
}
.fa-wordpress:before {
  content: "\f19a";
}
.fa-openid:before {
  content: "\f19b";
}
.fa-institution:before,
.fa-bank:before,
.fa-university:before {
  content: "\f19c";
}
.fa-mortar-board:before,
.fa-graduation-cap:before {
  content: "\f19d";
}
.fa-yahoo:before {
  content: "\f19e";
}
.fa-google:before {
  content: "\f1a0";
}
.fa-reddit:before {
  content: "\f1a1";
}
.fa-reddit-square:before {
  content: "\f1a2";
}
.fa-stumbleupon-circle:before {
  content: "\f1a3";
}
.fa-stumbleupon:before {
  content: "\f1a4";
}
.fa-delicious:before {
  content: "\f1a5";
}
.fa-digg:before {
  content: "\f1a6";
}
.fa-pied-piper-pp:before {
  content: "\f1a7";
}
.fa-pied-piper-alt:before {
  content: "\f1a8";
}
.fa-drupal:before {
  content: "\f1a9";
}
.fa-joomla:before {
  content: "\f1aa";
}
.fa-language:before {
  content: "\f1ab";
}
.fa-fax:before {
  content: "\f1ac";
}
.fa-building:before {
  content: "\f1ad";
}
.fa-child:before {
  content: "\f1ae";
}
.fa-paw:before {
  content: "\f1b0";
}
.fa-spoon:before {
  content: "\f1b1";
}
.fa-cube:before {
  content: "\f1b2";
}
.fa-cubes:before {
  content: "\f1b3";
}
.fa-behance:before {
  content: "\f1b4";
}
.fa-behance-square:before {
  content: "\f1b5";
}
.fa-steam:before {
  content: "\f1b6";
}
.fa-steam-square:before {
  content: "\f1b7";
}
.fa-recycle:before {
  content: "\f1b8";
}
.fa-automobile:before,
.fa-car:before {
  content: "\f1b9";
}
.fa-cab:before,
.fa-taxi:before {
  content: "\f1ba";
}
.fa-tree:before {
  content: "\f1bb";
}
.fa-spotify:before {
  content: "\f1bc";
}
.fa-deviantart:before {
  content: "\f1bd";
}
.fa-soundcloud:before {
  content: "\f1be";
}
.fa-database:before {
  content: "\f1c0";
}
.fa-file-pdf-o:before {
  content: "\f1c1";
}
.fa-file-word-o:before {
  content: "\f1c2";
}
.fa-file-excel-o:before {
  content: "\f1c3";
}
.fa-file-powerpoint-o:before {
  content: "\f1c4";
}
.fa-file-photo-o:before,
.fa-file-picture-o:before,
.fa-file-image-o:before {
  content: "\f1c5";
}
.fa-file-zip-o:before,
.fa-file-archive-o:before {
  content: "\f1c6";
}
.fa-file-sound-o:before,
.fa-file-audio-o:before {
  content: "\f1c7";
}
.fa-file-movie-o:before,
.fa-file-video-o:before {
  content: "\f1c8";
}
.fa-file-code-o:before {
  content: "\f1c9";
}
.fa-vine:before {
  content: "\f1ca";
}
.fa-codepen:before {
  content: "\f1cb";
}
.fa-jsfiddle:before {
  content: "\f1cc";
}
.fa-life-bouy:before,
.fa-life-buoy:before,
.fa-life-saver:before,
.fa-support:before,
.fa-life-ring:before {
  content: "\f1cd";
}
.fa-circle-o-notch:before {
  content: "\f1ce";
}
.fa-ra:before,
.fa-resistance:before,
.fa-rebel:before {
  content: "\f1d0";
}
.fa-ge:before,
.fa-empire:before {
  content: "\f1d1";
}
.fa-git-square:before {
  content: "\f1d2";
}
.fa-git:before {
  content: "\f1d3";
}
.fa-y-combinator-square:before,
.fa-yc-square:before,
.fa-hacker-news:before {
  content: "\f1d4";
}
.fa-tencent-weibo:before {
  content: "\f1d5";
}
.fa-qq:before {
  content: "\f1d6";
}
.fa-wechat:before,
.fa-weixin:before {
  content: "\f1d7";
}
.fa-send:before,
.fa-paper-plane:before {
  content: "\f1d8";
}
.fa-send-o:before,
.fa-paper-plane-o:before {
  content: "\f1d9";
}
.fa-history:before {
  content: "\f1da";
}
.fa-circle-thin:before {
  content: "\f1db";
}
.fa-header:before {
  content: "\f1dc";
}
.fa-paragraph:before {
  content: "\f1dd";
}
.fa-sliders:before {
  content: "\f1de";
}
.fa-share-alt:before {
  content: "\f1e0";
}
.fa-share-alt-square:before {
  content: "\f1e1";
}
.fa-bomb:before {
  content: "\f1e2";
}
.fa-soccer-ball-o:before,
.fa-futbol-o:before {
  content: "\f1e3";
}
.fa-tty:before {
  content: "\f1e4";
}
.fa-binoculars:before {
  content: "\f1e5";
}
.fa-plug:before {
  content: "\f1e6";
}
.fa-slideshare:before {
  content: "\f1e7";
}
.fa-twitch:before {
  content: "\f1e8";
}
.fa-yelp:before {
  content: "\f1e9";
}
.fa-newspaper-o:before {
  content: "\f1ea";
}
.fa-wifi:before {
  content: "\f1eb";
}
.fa-calculator:before {
  content: "\f1ec";
}
.fa-paypal:before {
  content: "\f1ed";
}
.fa-google-wallet:before {
  content: "\f1ee";
}
.fa-cc-visa:before {
  content: "\f1f0";
}
.fa-cc-mastercard:before {
  content: "\f1f1";
}
.fa-cc-discover:before {
  content: "\f1f2";
}
.fa-cc-amex:before {
  content: "\f1f3";
}
.fa-cc-paypal:before {
  content: "\f1f4";
}
.fa-cc-stripe:before {
  content: "\f1f5";
}
.fa-bell-slash:before {
  content: "\f1f6";
}
.fa-bell-slash-o:before {
  content: "\f1f7";
}
.fa-trash:before {
  content: "\f1f8";
}
.fa-copyright:before {
  content: "\f1f9";
}
.fa-at:before {
  content: "\f1fa";
}
.fa-eyedropper:before {
  content: "\f1fb";
}
.fa-paint-brush:before {
  content: "\f1fc";
}
.fa-birthday-cake:before {
  content: "\f1fd";
}
.fa-area-chart:before {
  content: "\f1fe";
}
.fa-pie-chart:before {
  content: "\f200";
}
.fa-line-chart:before {
  content: "\f201";
}
.fa-lastfm:before {
  content: "\f202";
}
.fa-lastfm-square:before {
  content: "\f203";
}
.fa-toggle-off:before {
  content: "\f204";
}
.fa-toggle-on:before {
  content: "\f205";
}
.fa-bicycle:before {
  content: "\f206";
}
.fa-bus:before {
  content: "\f207";
}
.fa-ioxhost:before {
  content: "\f208";
}
.fa-angellist:before {
  content: "\f209";
}
.fa-cc:before {
  content: "\f20a";
}
.fa-shekel:before,
.fa-sheqel:before,
.fa-ils:before {
  content: "\f20b";
}
.fa-meanpath:before {
  content: "\f20c";
}
.fa-buysellads:before {
  content: "\f20d";
}
.fa-connectdevelop:before {
  content: "\f20e";
}
.fa-dashcube:before {
  content: "\f210";
}
.fa-forumbee:before {
  content: "\f211";
}
.fa-leanpub:before {
  content: "\f212";
}
.fa-sellsy:before {
  content: "\f213";
}
.fa-shirtsinbulk:before {
  content: "\f214";
}
.fa-simplybuilt:before {
  content: "\f215";
}
.fa-skyatlas:before {
  content: "\f216";
}
.fa-cart-plus:before {
  content: "\f217";
}
.fa-cart-arrow-down:before {
  content: "\f218";
}
.fa-diamond:before {
  content: "\f219";
}
.fa-ship:before {
  content: "\f21a";
}
.fa-user-secret:before {
  content: "\f21b";
}
.fa-motorcycle:before {
  content: "\f21c";
}
.fa-street-view:before {
  content: "\f21d";
}
.fa-heartbeat:before {
  content: "\f21e";
}
.fa-venus:before {
  content: "\f221";
}
.fa-mars:before {
  content: "\f222";
}
.fa-mercury:before {
  content: "\f223";
}
.fa-intersex:before,
.fa-transgender:before {
  content: "\f224";
}
.fa-transgender-alt:before {
  content: "\f225";
}
.fa-venus-double:before {
  content: "\f226";
}
.fa-mars-double:before {
  content: "\f227";
}
.fa-venus-mars:before {
  content: "\f228";
}
.fa-mars-stroke:before {
  content: "\f229";
}
.fa-mars-stroke-v:before {
  content: "\f22a";
}
.fa-mars-stroke-h:before {
  content: "\f22b";
}
.fa-neuter:before {
  content: "\f22c";
}
.fa-genderless:before {
  content: "\f22d";
}
.fa-facebook-official:before {
  content: "\f230";
}
.fa-pinterest-p:before {
  content: "\f231";
}
.fa-whatsapp:before {
  content: "\f232";
}
.fa-server:before {
  content: "\f233";
}
.fa-user-plus:before {
  content: "\f234";
}
.fa-user-times:before {
  content: "\f235";
}
.fa-hotel:before,
.fa-bed:before {
  content: "\f236";
}
.fa-viacoin:before {
  content: "\f237";
}
.fa-train:before {
  content: "\f238";
}
.fa-subway:before {
  content: "\f239";
}
.fa-medium:before {
  content: "\f23a";
}
.fa-yc:before,
.fa-y-combinator:before {
  content: "\f23b";
}
.fa-optin-monster:before {
  content: "\f23c";
}
.fa-opencart:before {
  content: "\f23d";
}
.fa-expeditedssl:before {
  content: "\f23e";
}
.fa-battery-4:before,
.fa-battery:before,
.fa-battery-full:before {
  content: "\f240";
}
.fa-battery-3:before,
.fa-battery-three-quarters:before {
  content: "\f241";
}
.fa-battery-2:before,
.fa-battery-half:before {
  content: "\f242";
}
.fa-battery-1:before,
.fa-battery-quarter:before {
  content: "\f243";
}
.fa-battery-0:before,
.fa-battery-empty:before {
  content: "\f244";
}
.fa-mouse-pointer:before {
  content: "\f245";
}
.fa-i-cursor:before {
  content: "\f246";
}
.fa-object-group:before {
  content: "\f247";
}
.fa-object-ungroup:before {
  content: "\f248";
}
.fa-sticky-note:before {
  content: "\f249";
}
.fa-sticky-note-o:before {
  content: "\f24a";
}
.fa-cc-jcb:before {
  content: "\f24b";
}
.fa-cc-diners-club:before {
  content: "\f24c";
}
.fa-clone:before {
  content: "\f24d";
}
.fa-balance-scale:before {
  content: "\f24e";
}
.fa-hourglass-o:before {
  content: "\f250";
}
.fa-hourglass-1:before,
.fa-hourglass-start:before {
  content: "\f251";
}
.fa-hourglass-2:before,
.fa-hourglass-half:before {
  content: "\f252";
}
.fa-hourglass-3:before,
.fa-hourglass-end:before {
  content: "\f253";
}
.fa-hourglass:before {
  content: "\f254";
}
.fa-hand-grab-o:before,
.fa-hand-rock-o:before {
  content: "\f255";
}
.fa-hand-stop-o:before,
.fa-hand-paper-o:before {
  content: "\f256";
}
.fa-hand-scissors-o:before {
  content: "\f257";
}
.fa-hand-lizard-o:before {
  content: "\f258";
}
.fa-hand-spock-o:before {
  content: "\f259";
}
.fa-hand-pointer-o:before {
  content: "\f25a";
}
.fa-hand-peace-o:before {
  content: "\f25b";
}
.fa-trademark:before {
  content: "\f25c";
}
.fa-registered:before {
  content: "\f25d";
}
.fa-creative-commons:before {
  content: "\f25e";
}
.fa-gg:before {
  content: "\f260";
}
.fa-gg-circle:before {
  content: "\f261";
}
.fa-tripadvisor:before {
  content: "\f262";
}
.fa-odnoklassniki:before {
  content: "\f263";
}
.fa-odnoklassniki-square:before {
  content: "\f264";
}
.fa-get-pocket:before {
  content: "\f265";
}
.fa-wikipedia-w:before {
  content: "\f266";
}
.fa-safari:before {
  content: "\f267";
}
.fa-chrome:before {
  content: "\f268";
}
.fa-firefox:before {
  content: "\f269";
}
.fa-opera:before {
  content: "\f26a";
}
.fa-internet-explorer:before {
  content: "\f26b";
}
.fa-tv:before,
.fa-television:before {
  content: "\f26c";
}
.fa-contao:before {
  content: "\f26d";
}
.fa-500px:before {
  content: "\f26e";
}
.fa-amazon:before {
  content: "\f270";
}
.fa-calendar-plus-o:before {
  content: "\f271";
}
.fa-calendar-minus-o:before {
  content: "\f272";
}
.fa-calendar-times-o:before {
  content: "\f273";
}
.fa-calendar-check-o:before {
  content: "\f274";
}
.fa-industry:before {
  content: "\f275";
}
.fa-map-pin:before {
  content: "\f276";
}
.fa-map-signs:before {
  content: "\f277";
}
.fa-map-o:before {
  content: "\f278";
}
.fa-map:before {
  content: "\f279";
}
.fa-commenting:before {
  content: "\f27a";
}
.fa-commenting-o:before {
  content: "\f27b";
}
.fa-houzz:before {
  content: "\f27c";
}
.fa-vimeo:before {
  content: "\f27d";
}
.fa-black-tie:before {
  content: "\f27e";
}
.fa-fonticons:before {
  content: "\f280";
}
.fa-reddit-alien:before {
  content: "\f281";
}
.fa-edge:before {
  content: "\f282";
}
.fa-credit-card-alt:before {
  content: "\f283";
}
.fa-codiepie:before {
  content: "\f284";
}
.fa-modx:before {
  content: "\f285";
}
.fa-fort-awesome:before {
  content: "\f286";
}
.fa-usb:before {
  content: "\f287";
}
.fa-product-hunt:before {
  content: "\f288";
}
.fa-mixcloud:before {
  content: "\f289";
}
.fa-scribd:before {
  content: "\f28a";
}
.fa-pause-circle:before {
  content: "\f28b";
}
.fa-pause-circle-o:before {
  content: "\f28c";
}
.fa-stop-circle:before {
  content: "\f28d";
}
.fa-stop-circle-o:before {
  content: "\f28e";
}
.fa-shopping-bag:before {
  content: "\f290";
}
.fa-shopping-basket:before {
  content: "\f291";
}
.fa-hashtag:before {
  content: "\f292";
}
.fa-bluetooth:before {
  content: "\f293";
}
.fa-bluetooth-b:before {
  content: "\f294";
}
.fa-percent:before {
  content: "\f295";
}
.fa-gitlab:before {
  content: "\f296";
}
.fa-wpbeginner:before {
  content: "\f297";
}
.fa-wpforms:before {
  content: "\f298";
}
.fa-envira:before {
  content: "\f299";
}
.fa-universal-access:before {
  content: "\f29a";
}
.fa-wheelchair-alt:before {
  content: "\f29b";
}
.fa-question-circle-o:before {
  content: "\f29c";
}
.fa-blind:before {
  content: "\f29d";
}
.fa-audio-description:before {
  content: "\f29e";
}
.fa-volume-control-phone:before {
  content: "\f2a0";
}
.fa-braille:before {
  content: "\f2a1";
}
.fa-assistive-listening-systems:before {
  content: "\f2a2";
}
.fa-asl-interpreting:before,
.fa-american-sign-language-interpreting:before {
  content: "\f2a3";
}
.fa-deafness:before,
.fa-hard-of-hearing:before,
.fa-deaf:before {
  content: "\f2a4";
}
.fa-glide:before {
  content: "\f2a5";
}
.fa-glide-g:before {
  content: "\f2a6";
}
.fa-signing:before,
.fa-sign-language:before {
  content: "\f2a7";
}
.fa-low-vision:before {
  content: "\f2a8";
}
.fa-viadeo:before {
  content: "\f2a9";
}
.fa-viadeo-square:before {
  content: "\f2aa";
}
.fa-snapchat:before {
  content: "\f2ab";
}
.fa-snapchat-ghost:before {
  content: "\f2ac";
}
.fa-snapchat-square:before {
  content: "\f2ad";
}
.fa-pied-piper:before {
  content: "\f2ae";
}
.fa-first-order:before {
  content: "\f2b0";
}
.fa-yoast:before {
  content: "\f2b1";
}
.fa-themeisle:before {
  content: "\f2b2";
}
.fa-google-plus-circle:before,
.fa-google-plus-official:before {
  content: "\f2b3";
}
.fa-fa:before,
.fa-font-awesome:before {
  content: "\f2b4";
}
.fa-handshake-o:before {
  content: "\f2b5";
}
.fa-envelope-open:before {
  content: "\f2b6";
}
.fa-envelope-open-o:before {
  content: "\f2b7";
}
.fa-linode:before {
  content: "\f2b8";
}
.fa-address-book:before {
  content: "\f2b9";
}
.fa-address-book-o:before {
  content: "\f2ba";
}
.fa-vcard:before,
.fa-address-card:before {
  content: "\f2bb";
}
.fa-vcard-o:before,
.fa-address-card-o:before {
  content: "\f2bc";
}
.fa-user-circle:before {
  content: "\f2bd";
}
.fa-user-circle-o:before {
  content: "\f2be";
}
.fa-user-o:before {
  content: "\f2c0";
}
.fa-id-badge:before {
  content: "\f2c1";
}
.fa-drivers-license:before,
.fa-id-card:before {
  content: "\f2c2";
}
.fa-drivers-license-o:before,
.fa-id-card-o:before {
  content: "\f2c3";
}
.fa-quora:before {
  content: "\f2c4";
}
.fa-free-code-camp:before {
  content: "\f2c5";
}
.fa-telegram:before {
  content: "\f2c6";
}
.fa-thermometer-4:before,
.fa-thermometer:before,
.fa-thermometer-full:before {
  content: "\f2c7";
}
.fa-thermometer-3:before,
.fa-thermometer-three-quarters:before {
  content: "\f2c8";
}
.fa-thermometer-2:before,
.fa-thermometer-half:before {
  content: "\f2c9";
}
.fa-thermometer-1:before,
.fa-thermometer-quarter:before {
  content: "\f2ca";
}
.fa-thermometer-0:before,
.fa-thermometer-empty:before {
  content: "\f2cb";
}
.fa-shower:before {
  content: "\f2cc";
}
.fa-bathtub:before,
.fa-s15:before,
.fa-bath:before {
  content: "\f2cd";
}
.fa-podcast:before {
  content: "\f2ce";
}
.fa-window-maximize:before {
  content: "\f2d0";
}
.fa-window-minimize:before {
  content: "\f2d1";
}
.fa-window-restore:before {
  content: "\f2d2";
}
.fa-times-rectangle:before,
.fa-window-close:before {
  content: "\f2d3";
}
.fa-times-rectangle-o:before,
.fa-window-close-o:before {
  content: "\f2d4";
}
.fa-bandcamp:before {
  content: "\f2d5";
}
.fa-grav:before {
  content: "\f2d6";
}
.fa-etsy:before {
  content: "\f2d7";
}
.fa-imdb:before {
  content: "\f2d8";
}
.fa-ravelry:before {
  content: "\f2d9";
}
.fa-eercast:before {
  content: "\f2da";
}
.fa-microchip:before {
  content: "\f2db";
}
.fa-snowflake-o:before {
  content: "\f2dc";
}
.fa-superpowers:before {
  content: "\f2dd";
}
.fa-wpexplorer:before {
  content: "\f2de";
}
.fa-meetup:before {
  content: "\f2e0";
}
.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  padding: 0;
  margin: -1px;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  border: 0;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
/*!
*
* IPython base
*
*/
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
code {
  color: #000;
}
pre {
  font-size: inherit;
  line-height: inherit;
}
label {
  font-weight: normal;
}
/* Make the page background atleast 100% the height of the view port */
/* Make the page itself atleast 70% the height of the view port */
.border-box-sizing {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.corner-all {
  border-radius: 2px;
}
.no-padding {
  padding: 0px;
}
/* Flexible box model classes */
/* Taken from Alex Russell http://infrequently.org/2009/08/css-3-progress/ */
/* This file is a compatability layer.  It allows the usage of flexible box 
model layouts accross multiple browsers, including older browsers.  The newest,
universal implementation of the flexible box model is used when available (see
`Modern browsers` comments below).  Browsers that are known to implement this 
new spec completely include:

    Firefox 28.0+
    Chrome 29.0+
    Internet Explorer 11+ 
    Opera 17.0+

Browsers not listed, including Safari, are supported via the styling under the
`Old browsers` comments below.
*/
.hbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
.hbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.vbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
.vbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.hbox.reverse,
.vbox.reverse,
.reverse {
  /* Old browsers */
  -webkit-box-direction: reverse;
  -moz-box-direction: reverse;
  box-direction: reverse;
  /* Modern browsers */
  flex-direction: row-reverse;
}
.hbox.box-flex0,
.vbox.box-flex0,
.box-flex0 {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
  width: auto;
}
.hbox.box-flex1,
.vbox.box-flex1,
.box-flex1 {
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex,
.vbox.box-flex,
.box-flex {
  /* Old browsers */
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex2,
.vbox.box-flex2,
.box-flex2 {
  /* Old browsers */
  -webkit-box-flex: 2;
  -moz-box-flex: 2;
  box-flex: 2;
  /* Modern browsers */
  flex: 2;
}
.box-group1 {
  /*  Deprecated */
  -webkit-box-flex-group: 1;
  -moz-box-flex-group: 1;
  box-flex-group: 1;
}
.box-group2 {
  /* Deprecated */
  -webkit-box-flex-group: 2;
  -moz-box-flex-group: 2;
  box-flex-group: 2;
}
.hbox.start,
.vbox.start,
.start {
  /* Old browsers */
  -webkit-box-pack: start;
  -moz-box-pack: start;
  box-pack: start;
  /* Modern browsers */
  justify-content: flex-start;
}
.hbox.end,
.vbox.end,
.end {
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
}
.hbox.center,
.vbox.center,
.center {
  /* Old browsers */
  -webkit-box-pack: center;
  -moz-box-pack: center;
  box-pack: center;
  /* Modern browsers */
  justify-content: center;
}
.hbox.baseline,
.vbox.baseline,
.baseline {
  /* Old browsers */
  -webkit-box-pack: baseline;
  -moz-box-pack: baseline;
  box-pack: baseline;
  /* Modern browsers */
  justify-content: baseline;
}
.hbox.stretch,
.vbox.stretch,
.stretch {
  /* Old browsers */
  -webkit-box-pack: stretch;
  -moz-box-pack: stretch;
  box-pack: stretch;
  /* Modern browsers */
  justify-content: stretch;
}
.hbox.align-start,
.vbox.align-start,
.align-start {
  /* Old browsers */
  -webkit-box-align: start;
  -moz-box-align: start;
  box-align: start;
  /* Modern browsers */
  align-items: flex-start;
}
.hbox.align-end,
.vbox.align-end,
.align-end {
  /* Old browsers */
  -webkit-box-align: end;
  -moz-box-align: end;
  box-align: end;
  /* Modern browsers */
  align-items: flex-end;
}
.hbox.align-center,
.vbox.align-center,
.align-center {
  /* Old browsers */
  -webkit-box-align: center;
  -moz-box-align: center;
  box-align: center;
  /* Modern browsers */
  align-items: center;
}
.hbox.align-baseline,
.vbox.align-baseline,
.align-baseline {
  /* Old browsers */
  -webkit-box-align: baseline;
  -moz-box-align: baseline;
  box-align: baseline;
  /* Modern browsers */
  align-items: baseline;
}
.hbox.align-stretch,
.vbox.align-stretch,
.align-stretch {
  /* Old browsers */
  -webkit-box-align: stretch;
  -moz-box-align: stretch;
  box-align: stretch;
  /* Modern browsers */
  align-items: stretch;
}
div.error {
  margin: 2em;
  text-align: center;
}
div.error > h1 {
  font-size: 500%;
  line-height: normal;
}
div.error > p {
  font-size: 200%;
  line-height: normal;
}
div.traceback-wrapper {
  text-align: left;
  max-width: 800px;
  margin: auto;
}
div.traceback-wrapper pre.traceback {
  max-height: 600px;
  overflow: auto;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
body {
  background-color: #fff;
  /* This makes sure that the body covers the entire window and needs to
       be in a different element than the display: box in wrapper below */
  position: absolute;
  left: 0px;
  right: 0px;
  top: 0px;
  bottom: 0px;
  overflow: visible;
}
body > #header {
  /* Initially hidden to prevent FLOUC */
  display: none;
  background-color: #fff;
  /* Display over codemirror */
  position: relative;
  z-index: 100;
}
body > #header #header-container {
  display: flex;
  flex-direction: row;
  justify-content: space-between;
  padding: 5px;
  padding-bottom: 5px;
  padding-top: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
body > #header .header-bar {
  width: 100%;
  height: 1px;
  background: #e7e7e7;
  margin-bottom: -1px;
}
@media print {
  body > #header {
    display: none !important;
  }
}
#header-spacer {
  width: 100%;
  visibility: hidden;
}
@media print {
  #header-spacer {
    display: none;
  }
}
#ipython_notebook {
  padding-left: 0px;
  padding-top: 1px;
  padding-bottom: 1px;
}
[dir="rtl"] #ipython_notebook {
  margin-right: 10px;
  margin-left: 0;
}
[dir="rtl"] #ipython_notebook.pull-left {
  float: right !important;
  float: right;
}
.flex-spacer {
  flex: 1;
}
#noscript {
  width: auto;
  padding-top: 16px;
  padding-bottom: 16px;
  text-align: center;
  font-size: 22px;
  color: red;
  font-weight: bold;
}
#ipython_notebook img {
  height: 28px;
}
#site {
  width: 100%;
  display: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  overflow: auto;
}
@media print {
  #site {
    height: auto !important;
  }
}
/* Smaller buttons */
.ui-button .ui-button-text {
  padding: 0.2em 0.8em;
  font-size: 77%;
}
input.ui-button {
  padding: 0.3em 0.9em;
}
span#kernel_logo_widget {
  margin: 0 10px;
}
span#login_widget {
  float: right;
}
[dir="rtl"] span#login_widget {
  float: left;
}
span#login_widget > .button,
#logout {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button:focus,
#logout:focus,
span#login_widget > .button.focus,
#logout.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
span#login_widget > .button:hover,
#logout:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active:hover,
#logout:active:hover,
span#login_widget > .button.active:hover,
#logout.active:hover,
.open > .dropdown-togglespan#login_widget > .button:hover,
.open > .dropdown-toggle#logout:hover,
span#login_widget > .button:active:focus,
#logout:active:focus,
span#login_widget > .button.active:focus,
#logout.active:focus,
.open > .dropdown-togglespan#login_widget > .button:focus,
.open > .dropdown-toggle#logout:focus,
span#login_widget > .button:active.focus,
#logout:active.focus,
span#login_widget > .button.active.focus,
#logout.active.focus,
.open > .dropdown-togglespan#login_widget > .button.focus,
.open > .dropdown-toggle#logout.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  background-image: none;
}
span#login_widget > .button.disabled:hover,
#logout.disabled:hover,
span#login_widget > .button[disabled]:hover,
#logout[disabled]:hover,
fieldset[disabled] span#login_widget > .button:hover,
fieldset[disabled] #logout:hover,
span#login_widget > .button.disabled:focus,
#logout.disabled:focus,
span#login_widget > .button[disabled]:focus,
#logout[disabled]:focus,
fieldset[disabled] span#login_widget > .button:focus,
fieldset[disabled] #logout:focus,
span#login_widget > .button.disabled.focus,
#logout.disabled.focus,
span#login_widget > .button[disabled].focus,
#logout[disabled].focus,
fieldset[disabled] span#login_widget > .button.focus,
fieldset[disabled] #logout.focus {
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button .badge,
#logout .badge {
  color: #fff;
  background-color: #333;
}
.nav-header {
  text-transform: none;
}
#header > span {
  margin-top: 10px;
}
.modal_stretch .modal-dialog {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  min-height: 80vh;
}
.modal_stretch .modal-dialog .modal-body {
  max-height: calc(100vh - 200px);
  overflow: auto;
  flex: 1;
}
.modal-header {
  cursor: move;
}
@media (min-width: 768px) {
  .modal .modal-dialog {
    width: 700px;
  }
}
@media (min-width: 768px) {
  select.form-control {
    margin-left: 12px;
    margin-right: 12px;
  }
}
/*!
*
* IPython auth
*
*/
.center-nav {
  display: inline-block;
  margin-bottom: -4px;
}
[dir="rtl"] .center-nav form.pull-left {
  float: right !important;
  float: right;
}
[dir="rtl"] .center-nav .navbar-text {
  float: right;
}
[dir="rtl"] .navbar-inner {
  text-align: right;
}
[dir="rtl"] div.text-left {
  text-align: right;
}
/*!
*
* IPython tree view
*
*/
/* We need an invisible input field on top of the sentense*/
/* "Drag file onto the list ..." */
.alternate_upload {
  background-color: none;
  display: inline;
}
.alternate_upload.form {
  padding: 0;
  margin: 0;
}
.alternate_upload input.fileinput {
  position: absolute;
  display: block;
  width: 100%;
  height: 100%;
  overflow: hidden;
  cursor: pointer;
  opacity: 0;
  z-index: 2;
}
.alternate_upload .btn-xs > input.fileinput {
  margin: -1px -5px;
}
.alternate_upload .btn-upload {
  position: relative;
  height: 22px;
}
::-webkit-file-upload-button {
  cursor: pointer;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
ul#tabs {
  margin-bottom: 4px;
}
ul#tabs a {
  padding-top: 6px;
  padding-bottom: 4px;
}
[dir="rtl"] ul#tabs.nav-tabs > li {
  float: right;
}
[dir="rtl"] ul#tabs.nav.nav-tabs {
  padding-right: 0;
}
ul.breadcrumb a:focus,
ul.breadcrumb a:hover {
  text-decoration: none;
}
ul.breadcrumb i.icon-home {
  font-size: 16px;
  margin-right: 4px;
}
ul.breadcrumb span {
  color: #5e5e5e;
}
.list_toolbar {
  padding: 4px 0 4px 0;
  vertical-align: middle;
}
.list_toolbar .tree-buttons {
  padding-top: 1px;
}
[dir="rtl"] .list_toolbar .tree-buttons .pull-right {
  float: left !important;
  float: left;
}
[dir="rtl"] .list_toolbar .col-sm-4,
[dir="rtl"] .list_toolbar .col-sm-8 {
  float: right;
}
.dynamic-buttons {
  padding-top: 3px;
  display: inline-block;
}
.list_toolbar [class*="span"] {
  min-height: 24px;
}
.list_header {
  font-weight: bold;
  background-color: #EEE;
}
.list_placeholder {
  font-weight: bold;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
}
.list_container {
  margin-top: 4px;
  margin-bottom: 20px;
  border: 1px solid #ddd;
  border-radius: 2px;
}
.list_container > div {
  border-bottom: 1px solid #ddd;
}
.list_container > div:hover .list-item {
  background-color: red;
}
.list_container > div:last-child {
  border: none;
}
.list_item:hover .list_item {
  background-color: #ddd;
}
.list_item a {
  text-decoration: none;
}
.list_item:hover {
  background-color: #fafafa;
}
.list_header > div,
.list_item > div {
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
.list_header > div input,
.list_item > div input {
  margin-right: 7px;
  margin-left: 14px;
  vertical-align: text-bottom;
  line-height: 22px;
  position: relative;
  top: -1px;
}
.list_header > div .item_link,
.list_item > div .item_link {
  margin-left: -1px;
  vertical-align: baseline;
  line-height: 22px;
}
[dir="rtl"] .list_item > div input {
  margin-right: 0;
}
.new-file input[type=checkbox] {
  visibility: hidden;
}
.item_name {
  line-height: 22px;
  height: 24px;
}
.item_icon {
  font-size: 14px;
  color: #5e5e5e;
  margin-right: 7px;
  margin-left: 7px;
  line-height: 22px;
  vertical-align: baseline;
}
.item_modified {
  margin-right: 7px;
  margin-left: 7px;
}
[dir="rtl"] .item_modified.pull-right {
  float: left !important;
  float: left;
}
.item_buttons {
  line-height: 1em;
  margin-left: -5px;
}
.item_buttons .btn,
.item_buttons .btn-group,
.item_buttons .input-group {
  float: left;
}
.item_buttons > .btn,
.item_buttons > .btn-group,
.item_buttons > .input-group {
  margin-left: 5px;
}
.item_buttons .btn {
  min-width: 13ex;
}
.item_buttons .running-indicator {
  padding-top: 4px;
  color: #5cb85c;
}
.item_buttons .kernel-name {
  padding-top: 4px;
  color: #5bc0de;
  margin-right: 7px;
  float: left;
}
[dir="rtl"] .item_buttons.pull-right {
  float: left !important;
  float: left;
}
[dir="rtl"] .item_buttons .kernel-name {
  margin-left: 7px;
  float: right;
}
.toolbar_info {
  height: 24px;
  line-height: 24px;
}
.list_item input:not([type=checkbox]) {
  padding-top: 3px;
  padding-bottom: 3px;
  height: 22px;
  line-height: 14px;
  margin: 0px;
}
.highlight_text {
  color: blue;
}
#project_name {
  display: inline-block;
  padding-left: 7px;
  margin-left: -2px;
}
#project_name > .breadcrumb {
  padding: 0px;
  margin-bottom: 0px;
  background-color: transparent;
  font-weight: bold;
}
.sort_button {
  display: inline-block;
  padding-left: 7px;
}
[dir="rtl"] .sort_button.pull-right {
  float: left !important;
  float: left;
}
#tree-selector {
  padding-right: 0px;
}
#button-select-all {
  min-width: 50px;
}
[dir="rtl"] #button-select-all.btn {
  float: right ;
}
#select-all {
  margin-left: 7px;
  margin-right: 2px;
  margin-top: 2px;
  height: 16px;
}
[dir="rtl"] #select-all.pull-left {
  float: right !important;
  float: right;
}
.menu_icon {
  margin-right: 2px;
}
.tab-content .row {
  margin-left: 0px;
  margin-right: 0px;
}
.folder_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f114";
}
.folder_icon:before.fa-pull-left {
  margin-right: .3em;
}
.folder_icon:before.fa-pull-right {
  margin-left: .3em;
}
.folder_icon:before.pull-left {
  margin-right: .3em;
}
.folder_icon:before.pull-right {
  margin-left: .3em;
}
.notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
}
.notebook_icon:before.fa-pull-left {
  margin-right: .3em;
}
.notebook_icon:before.fa-pull-right {
  margin-left: .3em;
}
.notebook_icon:before.pull-left {
  margin-right: .3em;
}
.notebook_icon:before.pull-right {
  margin-left: .3em;
}
.running_notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
  color: #5cb85c;
}
.running_notebook_icon:before.fa-pull-left {
  margin-right: .3em;
}
.running_notebook_icon:before.fa-pull-right {
  margin-left: .3em;
}
.running_notebook_icon:before.pull-left {
  margin-right: .3em;
}
.running_notebook_icon:before.pull-right {
  margin-left: .3em;
}
.file_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f016";
  position: relative;
  top: -2px;
}
.file_icon:before.fa-pull-left {
  margin-right: .3em;
}
.file_icon:before.fa-pull-right {
  margin-left: .3em;
}
.file_icon:before.pull-left {
  margin-right: .3em;
}
.file_icon:before.pull-right {
  margin-left: .3em;
}
#notebook_toolbar .pull-right {
  padding-top: 0px;
  margin-right: -1px;
}
ul#new-menu {
  left: auto;
  right: 0;
}
#new-menu .dropdown-header {
  font-size: 10px;
  border-bottom: 1px solid #e5e5e5;
  padding: 0 0 3px;
  margin: -3px 20px 0;
}
.kernel-menu-icon {
  padding-right: 12px;
  width: 24px;
  content: "\f096";
}
.kernel-menu-icon:before {
  content: "\f096";
}
.kernel-menu-icon-current:before {
  content: "\f00c";
}
#tab_content {
  padding-top: 20px;
}
#running .panel-group .panel {
  margin-top: 3px;
  margin-bottom: 1em;
}
#running .panel-group .panel .panel-heading {
  background-color: #EEE;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
#running .panel-group .panel .panel-heading a:focus,
#running .panel-group .panel .panel-heading a:hover {
  text-decoration: none;
}
#running .panel-group .panel .panel-body {
  padding: 0px;
}
#running .panel-group .panel .panel-body .list_container {
  margin-top: 0px;
  margin-bottom: 0px;
  border: 0px;
  border-radius: 0px;
}
#running .panel-group .panel .panel-body .list_container .list_item {
  border-bottom: 1px solid #ddd;
}
#running .panel-group .panel .panel-body .list_container .list_item:last-child {
  border-bottom: 0px;
}
.delete-button {
  display: none;
}
.duplicate-button {
  display: none;
}
.rename-button {
  display: none;
}
.move-button {
  display: none;
}
.download-button {
  display: none;
}
.shutdown-button {
  display: none;
}
.dynamic-instructions {
  display: inline-block;
  padding-top: 4px;
}
/*!
*
* IPython text editor webapp
*
*/
.selected-keymap i.fa {
  padding: 0px 5px;
}
.selected-keymap i.fa:before {
  content: "\f00c";
}
#mode-menu {
  overflow: auto;
  max-height: 20em;
}
.edit_app #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
.edit_app #menubar .navbar {
  /* Use a negative 1 bottom margin, so the border overlaps the border of the
    header */
  margin-bottom: -1px;
}
.dirty-indicator {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator.fa-pull-left {
  margin-right: .3em;
}
.dirty-indicator.fa-pull-right {
  margin-left: .3em;
}
.dirty-indicator.pull-left {
  margin-right: .3em;
}
.dirty-indicator.pull-right {
  margin-left: .3em;
}
.dirty-indicator-dirty {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-dirty.fa-pull-left {
  margin-right: .3em;
}
.dirty-indicator-dirty.fa-pull-right {
  margin-left: .3em;
}
.dirty-indicator-dirty.pull-left {
  margin-right: .3em;
}
.dirty-indicator-dirty.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-clean.fa-pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean.fa-pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f00c";
}
.dirty-indicator-clean:before.fa-pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean:before.fa-pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean:before.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean:before.pull-right {
  margin-left: .3em;
}
#filename {
  font-size: 16pt;
  display: table;
  padding: 0px 5px;
}
#current-mode {
  padding-left: 5px;
  padding-right: 5px;
}
#texteditor-backdrop {
  padding-top: 20px;
  padding-bottom: 20px;
}
@media not print {
  #texteditor-backdrop {
    background-color: #EEE;
  }
}
@media print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container {
    padding: 0px;
    background-color: #fff;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
.CodeMirror-dialog {
  background-color: #fff;
}
/*!
*
* IPython notebook
*
*/
/* CSS font colors for translated ANSI escape sequences */
/* The color values are a mix of
   http://www.xcolors.net/dl/baskerville-ivorylight and
   http://www.xcolors.net/dl/euphrasia */
.ansi-black-fg {
  color: #3E424D;
}
.ansi-black-bg {
  background-color: #3E424D;
}
.ansi-black-intense-fg {
  color: #282C36;
}
.ansi-black-intense-bg {
  background-color: #282C36;
}
.ansi-red-fg {
  color: #E75C58;
}
.ansi-red-bg {
  background-color: #E75C58;
}
.ansi-red-intense-fg {
  color: #B22B31;
}
.ansi-red-intense-bg {
  background-color: #B22B31;
}
.ansi-green-fg {
  color: #00A250;
}
.ansi-green-bg {
  background-color: #00A250;
}
.ansi-green-intense-fg {
  color: #007427;
}
.ansi-green-intense-bg {
  background-color: #007427;
}
.ansi-yellow-fg {
  color: #DDB62B;
}
.ansi-yellow-bg {
  background-color: #DDB62B;
}
.ansi-yellow-intense-fg {
  color: #B27D12;
}
.ansi-yellow-intense-bg {
  background-color: #B27D12;
}
.ansi-blue-fg {
  color: #208FFB;
}
.ansi-blue-bg {
  background-color: #208FFB;
}
.ansi-blue-intense-fg {
  color: #0065CA;
}
.ansi-blue-intense-bg {
  background-color: #0065CA;
}
.ansi-magenta-fg {
  color: #D160C4;
}
.ansi-magenta-bg {
  background-color: #D160C4;
}
.ansi-magenta-intense-fg {
  color: #A03196;
}
.ansi-magenta-intense-bg {
  background-color: #A03196;
}
.ansi-cyan-fg {
  color: #60C6C8;
}
.ansi-cyan-bg {
  background-color: #60C6C8;
}
.ansi-cyan-intense-fg {
  color: #258F8F;
}
.ansi-cyan-intense-bg {
  background-color: #258F8F;
}
.ansi-white-fg {
  color: #C5C1B4;
}
.ansi-white-bg {
  background-color: #C5C1B4;
}
.ansi-white-intense-fg {
  color: #A1A6B2;
}
.ansi-white-intense-bg {
  background-color: #A1A6B2;
}
.ansi-default-inverse-fg {
  color: #FFFFFF;
}
.ansi-default-inverse-bg {
  background-color: #000000;
}
.ansi-bold {
  font-weight: bold;
}
.ansi-underline {
  text-decoration: underline;
}
/* The following styles are deprecated an will be removed in a future version */
.ansibold {
  font-weight: bold;
}
.ansi-inverse {
  outline: 0.5px dotted;
}
/* use dark versions for foreground, to improve visibility */
.ansiblack {
  color: black;
}
.ansired {
  color: darkred;
}
.ansigreen {
  color: darkgreen;
}
.ansiyellow {
  color: #c4a000;
}
.ansiblue {
  color: darkblue;
}
.ansipurple {
  color: darkviolet;
}
.ansicyan {
  color: steelblue;
}
.ansigray {
  color: gray;
}
/* and light for background, for the same reason */
.ansibgblack {
  background-color: black;
}
.ansibgred {
  background-color: red;
}
.ansibggreen {
  background-color: green;
}
.ansibgyellow {
  background-color: yellow;
}
.ansibgblue {
  background-color: blue;
}
.ansibgpurple {
  background-color: magenta;
}
.ansibgcyan {
  background-color: cyan;
}
.ansibggray {
  background-color: gray;
}
div.cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  border-radius: 2px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  border-width: 1px;
  border-style: solid;
  border-color: transparent;
  width: 100%;
  padding: 5px;
  /* This acts as a spacer between cells, that is outside the border */
  margin: 0px;
  outline: none;
  position: relative;
  overflow: visible;
}
div.cell:before {
  position: absolute;
  display: block;
  top: -1px;
  left: -1px;
  width: 5px;
  height: calc(100% +  2px);
  content: '';
  background: transparent;
}
div.cell.jupyter-soft-selected {
  border-left-color: #E3F2FD;
  border-left-width: 1px;
  padding-left: 5px;
  border-right-color: #E3F2FD;
  border-right-width: 1px;
  background: #E3F2FD;
}
@media print {
  div.cell.jupyter-soft-selected {
    border-color: transparent;
  }
}
div.cell.selected,
div.cell.selected.jupyter-soft-selected {
  border-color: #ababab;
}
div.cell.selected:before,
div.cell.selected.jupyter-soft-selected:before {
  position: absolute;
  display: block;
  top: -1px;
  left: -1px;
  width: 5px;
  height: calc(100% +  2px);
  content: '';
  background: #42A5F5;
}
@media print {
  div.cell.selected,
  div.cell.selected.jupyter-soft-selected {
    border-color: transparent;
  }
}
.edit_mode div.cell.selected {
  border-color: #66BB6A;
}
.edit_mode div.cell.selected:before {
  position: absolute;
  display: block;
  top: -1px;
  left: -1px;
  width: 5px;
  height: calc(100% +  2px);
  content: '';
  background: #66BB6A;
}
@media print {
  .edit_mode div.cell.selected {
    border-color: transparent;
  }
}
.prompt {
  /* This needs to be wide enough for 3 digit prompt numbers: In[100]: */
  min-width: 14ex;
  /* This padding is tuned to match the padding on the CodeMirror editor. */
  padding: 0.4em;
  margin: 0px;
  font-family: monospace;
  text-align: right;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
  /* Don't highlight prompt number selection */
  -webkit-touch-callout: none;
  -webkit-user-select: none;
  -khtml-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
  /* Use default cursor */
  cursor: default;
}
@media (max-width: 540px) {
  .prompt {
    text-align: left;
  }
}
div.inner_cell {
  min-width: 0;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_area {
  border: 1px solid #cfcfcf;
  border-radius: 2px;
  background: #f7f7f7;
  line-height: 1.21429em;
}
/* This is needed so that empty prompt areas can collapse to zero height when there
   is no content in the output_subarea and the prompt. The main purpose of this is
   to make sure that empty JavaScript output_subareas have no height. */
div.prompt:empty {
  padding-top: 0;
  padding-bottom: 0;
}
div.unrecognized_cell {
  padding: 5px 5px 5px 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.unrecognized_cell .inner_cell {
  border-radius: 2px;
  padding: 5px;
  font-weight: bold;
  color: red;
  border: 1px solid #cfcfcf;
  background: #eaeaea;
}
div.unrecognized_cell .inner_cell a {
  color: inherit;
  text-decoration: none;
}
div.unrecognized_cell .inner_cell a:hover {
  color: inherit;
  text-decoration: none;
}
@media (max-width: 540px) {
  div.unrecognized_cell > div.prompt {
    display: none;
  }
}
div.code_cell {
  /* avoid page breaking on code cells when printing */
}
@media print {
  div.code_cell {
    page-break-inside: avoid;
  }
}
/* any special styling for code cells that are currently running goes here */
div.input {
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.input {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_prompt {
  color: #303F9F;
  border-top: 1px solid transparent;
}
div.input_area > div.highlight {
  margin: 0.4em;
  border: none;
  padding: 0px;
  background-color: transparent;
}
div.input_area > div.highlight > pre {
  margin: 0px;
  border: none;
  padding: 0px;
  background-color: transparent;
}
/* The following gets added to the <head> if it is detected that the user has a
 * monospace font with inconsistent normal/bold/italic height.  See
 * notebookmain.js.  Such fonts will have keywords vertically offset with
 * respect to the rest of the text.  The user should select a better font.
 * See: https://github.com/ipython/ipython/issues/1503
 *
 * .CodeMirror span {
 *      vertical-align: bottom;
 * }
 */
.CodeMirror {
  line-height: 1.21429em;
  /* Changed from 1em to our global default */
  font-size: 14px;
  height: auto;
  /* Changed to auto to autogrow */
  background: none;
  /* Changed from white to allow our bg to show through */
}
.CodeMirror-scroll {
  /*  The CodeMirror docs are a bit fuzzy on if overflow-y should be hidden or visible.*/
  /*  We have found that if it is visible, vertical scrollbars appear with font size changes.*/
  overflow-y: hidden;
  overflow-x: auto;
}
.CodeMirror-lines {
  /* In CM2, this used to be 0.4em, but in CM3 it went to 4px. We need the em value because */
  /* we have set a different line-height and want this to scale with that. */
  /* Note that this should set vertical padding only, since CodeMirror assumes
       that horizontal padding will be set on CodeMirror pre */
  padding: 0.4em 0;
}
.CodeMirror-linenumber {
  padding: 0 8px 0 4px;
}
.CodeMirror-gutters {
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.CodeMirror pre {
  /* In CM3 this went to 4px from 0 in CM2. This sets horizontal padding only,
    use .CodeMirror-lines for vertical */
  padding: 0 0.4em;
  border: 0;
  border-radius: 0;
}
.CodeMirror-cursor {
  border-left: 1.4px solid black;
}
@media screen and (min-width: 2138px) and (max-width: 4319px) {
  .CodeMirror-cursor {
    border-left: 2px solid black;
  }
}
@media screen and (min-width: 4320px) {
  .CodeMirror-cursor {
    border-left: 4px solid black;
  }
}
/*

Original style from softwaremaniacs.org (c) Ivan Sagalaev <Maniac@SoftwareManiacs.Org>
Adapted from GitHub theme

*/
.highlight-base {
  color: #000;
}
.highlight-variable {
  color: #000;
}
.highlight-variable-2 {
  color: #1a1a1a;
}
.highlight-variable-3 {
  color: #333333;
}
.highlight-string {
  color: #BA2121;
}
.highlight-comment {
  color: #408080;
  font-style: italic;
}
.highlight-number {
  color: #080;
}
.highlight-atom {
  color: #88F;
}
.highlight-keyword {
  color: #008000;
  font-weight: bold;
}
.highlight-builtin {
  color: #008000;
}
.highlight-error {
  color: #f00;
}
.highlight-operator {
  color: #AA22FF;
  font-weight: bold;
}
.highlight-meta {
  color: #AA22FF;
}
/* previously not defined, copying from default codemirror */
.highlight-def {
  color: #00f;
}
.highlight-string-2 {
  color: #f50;
}
.highlight-qualifier {
  color: #555;
}
.highlight-bracket {
  color: #997;
}
.highlight-tag {
  color: #170;
}
.highlight-attribute {
  color: #00c;
}
.highlight-header {
  color: blue;
}
.highlight-quote {
  color: #090;
}
.highlight-link {
  color: #00c;
}
/* apply the same style to codemirror */
.cm-s-ipython span.cm-keyword {
  color: #008000;
  font-weight: bold;
}
.cm-s-ipython span.cm-atom {
  color: #88F;
}
.cm-s-ipython span.cm-number {
  color: #080;
}
.cm-s-ipython span.cm-def {
  color: #00f;
}
.cm-s-ipython span.cm-variable {
  color: #000;
}
.cm-s-ipython span.cm-operator {
  color: #AA22FF;
  font-weight: bold;
}
.cm-s-ipython span.cm-variable-2 {
  color: #1a1a1a;
}
.cm-s-ipython span.cm-variable-3 {
  color: #333333;
}
.cm-s-ipython span.cm-comment {
  color: #408080;
  font-style: italic;
}
.cm-s-ipython span.cm-string {
  color: #BA2121;
}
.cm-s-ipython span.cm-string-2 {
  color: #f50;
}
.cm-s-ipython span.cm-meta {
  color: #AA22FF;
}
.cm-s-ipython span.cm-qualifier {
  color: #555;
}
.cm-s-ipython span.cm-builtin {
  color: #008000;
}
.cm-s-ipython span.cm-bracket {
  color: #997;
}
.cm-s-ipython span.cm-tag {
  color: #170;
}
.cm-s-ipython span.cm-attribute {
  color: #00c;
}
.cm-s-ipython span.cm-header {
  color: blue;
}
.cm-s-ipython span.cm-quote {
  color: #090;
}
.cm-s-ipython span.cm-link {
  color: #00c;
}
.cm-s-ipython span.cm-error {
  color: #f00;
}
.cm-s-ipython span.cm-tab {
  background: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAADAAAAAMCAYAAAAkuj5RAAAAAXNSR0IArs4c6QAAAGFJREFUSMft1LsRQFAQheHPowAKoACx3IgEKtaEHujDjORSgWTH/ZOdnZOcM/sgk/kFFWY0qV8foQwS4MKBCS3qR6ixBJvElOobYAtivseIE120FaowJPN75GMu8j/LfMwNjh4HUpwg4LUAAAAASUVORK5CYII=);
  background-position: right;
  background-repeat: no-repeat;
}
div.output_wrapper {
  /* this position must be relative to enable descendents to be absolute within it */
  position: relative;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  z-index: 1;
}
/* class for the output area when it should be height-limited */
div.output_scroll {
  /* ideally, this would be max-height, but FF barfs all over that */
  height: 24em;
  /* FF needs this *and the wrapper* to specify full width, or it will shrinkwrap */
  width: 100%;
  overflow: auto;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  display: block;
}
/* output div while it is collapsed */
div.output_collapsed {
  margin: 0px;
  padding: 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
div.out_prompt_overlay {
  height: 100%;
  padding: 0px 0.4em;
  position: absolute;
  border-radius: 2px;
}
div.out_prompt_overlay:hover {
  /* use inner shadow to get border that is computed the same on WebKit/FF */
  -webkit-box-shadow: inset 0 0 1px #000;
  box-shadow: inset 0 0 1px #000;
  background: rgba(240, 240, 240, 0.5);
}
div.output_prompt {
  color: #D84315;
}
/* This class is the outer container of all output sections. */
div.output_area {
  padding: 0px;
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.output_area .MathJax_Display {
  text-align: left !important;
}
div.output_area .rendered_html table {
  margin-left: 0;
  margin-right: 0;
}
div.output_area .rendered_html img {
  margin-left: 0;
  margin-right: 0;
}
div.output_area img,
div.output_area svg {
  max-width: 100%;
  height: auto;
}
div.output_area img.unconfined,
div.output_area svg.unconfined {
  max-width: none;
}
div.output_area .mglyph > img {
  max-width: none;
}
/* This is needed to protect the pre formating from global settings such
   as that of bootstrap */
.output {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.output_area {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
div.output_area pre {
  margin: 0;
  padding: 1px 0 1px 0;
  border: 0;
  vertical-align: baseline;
  color: black;
  background-color: transparent;
  border-radius: 0;
}
/* This class is for the output subarea inside the output_area and after
   the prompt div. */
div.output_subarea {
  overflow-x: auto;
  padding: 0.4em;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
  max-width: calc(100% - 14ex);
}
div.output_scroll div.output_subarea {
  overflow-x: visible;
}
/* The rest of the output_* classes are for special styling of the different
   output types */
/* all text output has this class: */
div.output_text {
  text-align: left;
  color: #000;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
}
/* stdout/stderr are 'text' as well as 'stream', but execute_result/error are *not* streams */
div.output_stderr {
  background: #fdd;
  /* very light red background for stderr */
}
div.output_latex {
  text-align: left;
}
/* Empty output_javascript divs should have no height */
div.output_javascript:empty {
  padding: 0;
}
.js-error {
  color: darkred;
}
/* raw_input styles */
div.raw_input_container {
  line-height: 1.21429em;
  padding-top: 5px;
}
pre.raw_input_prompt {
  /* nothing needed here. */
}
input.raw_input {
  font-family: monospace;
  font-size: inherit;
  color: inherit;
  width: auto;
  /* make sure input baseline aligns with prompt */
  vertical-align: baseline;
  /* padding + margin = 0.5em between prompt and cursor */
  padding: 0em 0.25em;
  margin: 0em 0.25em;
}
input.raw_input:focus {
  box-shadow: none;
}
p.p-space {
  margin-bottom: 10px;
}
div.output_unrecognized {
  padding: 5px;
  font-weight: bold;
  color: red;
}
div.output_unrecognized a {
  color: inherit;
  text-decoration: none;
}
div.output_unrecognized a:hover {
  color: inherit;
  text-decoration: none;
}
.rendered_html {
  color: #000;
  /* any extras will just be numbers: */
}
.rendered_html em {
  font-style: italic;
}
.rendered_html strong {
  font-weight: bold;
}
.rendered_html u {
  text-decoration: underline;
}
.rendered_html :link {
  text-decoration: underline;
}
.rendered_html :visited {
  text-decoration: underline;
}
.rendered_html h1 {
  font-size: 185.7%;
  margin: 1.08em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h2 {
  font-size: 157.1%;
  margin: 1.27em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h3 {
  font-size: 128.6%;
  margin: 1.55em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h4 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h5 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h6 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h1:first-child {
  margin-top: 0.538em;
}
.rendered_html h2:first-child {
  margin-top: 0.636em;
}
.rendered_html h3:first-child {
  margin-top: 0.777em;
}
.rendered_html h4:first-child {
  margin-top: 1em;
}
.rendered_html h5:first-child {
  margin-top: 1em;
}
.rendered_html h6:first-child {
  margin-top: 1em;
}
.rendered_html ul:not(.list-inline),
.rendered_html ol:not(.list-inline) {
  padding-left: 2em;
}
.rendered_html ul {
  list-style: disc;
}
.rendered_html ul ul {
  list-style: square;
  margin-top: 0;
}
.rendered_html ul ul ul {
  list-style: circle;
}
.rendered_html ol {
  list-style: decimal;
}
.rendered_html ol ol {
  list-style: upper-alpha;
  margin-top: 0;
}
.rendered_html ol ol ol {
  list-style: lower-alpha;
}
.rendered_html ol ol ol ol {
  list-style: lower-roman;
}
.rendered_html ol ol ol ol ol {
  list-style: decimal;
}
.rendered_html * + ul {
  margin-top: 1em;
}
.rendered_html * + ol {
  margin-top: 1em;
}
.rendered_html hr {
  color: black;
  background-color: black;
}
.rendered_html pre {
  margin: 1em 2em;
  padding: 0px;
  background-color: #fff;
}
.rendered_html code {
  background-color: #eff0f1;
}
.rendered_html p code {
  padding: 1px 5px;
}
.rendered_html pre code {
  background-color: #fff;
}
.rendered_html pre,
.rendered_html code {
  border: 0;
  color: #000;
  font-size: 100%;
}
.rendered_html blockquote {
  margin: 1em 2em;
}
.rendered_html table {
  margin-left: auto;
  margin-right: auto;
  border: none;
  border-collapse: collapse;
  border-spacing: 0;
  color: black;
  font-size: 12px;
  table-layout: fixed;
}
.rendered_html thead {
  border-bottom: 1px solid black;
  vertical-align: bottom;
}
.rendered_html tr,
.rendered_html th,
.rendered_html td {
  text-align: right;
  vertical-align: middle;
  padding: 0.5em 0.5em;
  line-height: normal;
  white-space: normal;
  max-width: none;
  border: none;
}
.rendered_html th {
  font-weight: bold;
}
.rendered_html tbody tr:nth-child(odd) {
  background: #f5f5f5;
}
.rendered_html tbody tr:hover {
  background: rgba(66, 165, 245, 0.2);
}
.rendered_html * + table {
  margin-top: 1em;
}
.rendered_html p {
  text-align: left;
}
.rendered_html * + p {
  margin-top: 1em;
}
.rendered_html img {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.rendered_html * + img {
  margin-top: 1em;
}
.rendered_html img,
.rendered_html svg {
  max-width: 100%;
  height: auto;
}
.rendered_html img.unconfined,
.rendered_html svg.unconfined {
  max-width: none;
}
.rendered_html .alert {
  margin-bottom: initial;
}
.rendered_html * + .alert {
  margin-top: 1em;
}
[dir="rtl"] .rendered_html p {
  text-align: right;
}
div.text_cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.text_cell > div.prompt {
    display: none;
  }
}
div.text_cell_render {
  /*font-family: "Helvetica Neue", Arial, Helvetica, Geneva, sans-serif;*/
  outline: none;
  resize: none;
  width: inherit;
  border-style: none;
  padding: 0.5em 0.5em 0.5em 0.4em;
  color: #000;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
a.anchor-link:link {
  text-decoration: none;
  padding: 0px 20px;
  visibility: hidden;
}
h1:hover .anchor-link,
h2:hover .anchor-link,
h3:hover .anchor-link,
h4:hover .anchor-link,
h5:hover .anchor-link,
h6:hover .anchor-link {
  visibility: visible;
}
.text_cell.rendered .input_area {
  display: none;
}
.text_cell.rendered .rendered_html {
  overflow-x: auto;
  overflow-y: hidden;
}
.text_cell.rendered .rendered_html tr,
.text_cell.rendered .rendered_html th,
.text_cell.rendered .rendered_html td {
  max-width: none;
}
.text_cell.unrendered .text_cell_render {
  display: none;
}
.text_cell .dropzone .input_area {
  border: 2px dashed #bababa;
  margin: -1px;
}
.cm-header-1,
.cm-header-2,
.cm-header-3,
.cm-header-4,
.cm-header-5,
.cm-header-6 {
  font-weight: bold;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
}
.cm-header-1 {
  font-size: 185.7%;
}
.cm-header-2 {
  font-size: 157.1%;
}
.cm-header-3 {
  font-size: 128.6%;
}
.cm-header-4 {
  font-size: 110%;
}
.cm-header-5 {
  font-size: 100%;
  font-style: italic;
}
.cm-header-6 {
  font-size: 100%;
  font-style: italic;
}
/*!
*
* IPython notebook webapp
*
*/
@media (max-width: 767px) {
  .notebook_app {
    padding-left: 0px;
    padding-right: 0px;
  }
}
#ipython-main-app {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook_panel {
  margin: 0px;
  padding: 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook {
  font-size: 14px;
  line-height: 20px;
  overflow-y: hidden;
  overflow-x: auto;
  width: 100%;
  /* This spaces the page away from the edge of the notebook area */
  padding-top: 20px;
  margin: 0px;
  outline: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  min-height: 100%;
}
@media not print {
  #notebook-container {
    padding: 15px;
    background-color: #fff;
    min-height: 0;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
@media print {
  #notebook-container {
    width: 100%;
  }
}
div.ui-widget-content {
  border: 1px solid #ababab;
  outline: none;
}
pre.dialog {
  background-color: #f7f7f7;
  border: 1px solid #ddd;
  border-radius: 2px;
  padding: 0.4em;
  padding-left: 2em;
}
p.dialog {
  padding: 0.2em;
}
/* Word-wrap output correctly.  This is the CSS3 spelling, though Firefox seems
   to not honor it correctly.  Webkit browsers (Chrome, rekonq, Safari) do.
 */
pre,
code,
kbd,
samp {
  white-space: pre-wrap;
}
#fonttest {
  font-family: monospace;
}
p {
  margin-bottom: 0;
}
.end_space {
  min-height: 100px;
  transition: height .2s ease;
}
.notebook_app > #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
@media not print {
  .notebook_app {
    background-color: #EEE;
  }
}
kbd {
  border-style: solid;
  border-width: 1px;
  box-shadow: none;
  margin: 2px;
  padding-left: 2px;
  padding-right: 2px;
  padding-top: 1px;
  padding-bottom: 1px;
}
.jupyter-keybindings {
  padding: 1px;
  line-height: 24px;
  border-bottom: 1px solid gray;
}
.jupyter-keybindings input {
  margin: 0;
  padding: 0;
  border: none;
}
.jupyter-keybindings i {
  padding: 6px;
}
.well code {
  background-color: #ffffff;
  border-color: #ababab;
  border-width: 1px;
  border-style: solid;
  padding: 2px;
  padding-top: 1px;
  padding-bottom: 1px;
}
/* CSS for the cell toolbar */
.celltoolbar {
  border: thin solid #CFCFCF;
  border-bottom: none;
  background: #EEE;
  border-radius: 2px 2px 0px 0px;
  width: 100%;
  height: 29px;
  padding-right: 4px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
  display: -webkit-flex;
}
@media print {
  .celltoolbar {
    display: none;
  }
}
.ctb_hideshow {
  display: none;
  vertical-align: bottom;
}
/* ctb_show is added to the ctb_hideshow div to show the cell toolbar.
   Cell toolbars are only shown when the ctb_global_show class is also set.
*/
.ctb_global_show .ctb_show.ctb_hideshow {
  display: block;
}
.ctb_global_show .ctb_show + .input_area,
.ctb_global_show .ctb_show + div.text_cell_input,
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border-top-right-radius: 0px;
  border-top-left-radius: 0px;
}
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border: 1px solid #cfcfcf;
}
.celltoolbar {
  font-size: 87%;
  padding-top: 3px;
}
.celltoolbar select {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
  width: inherit;
  font-size: inherit;
  height: 22px;
  padding: 0px;
  display: inline-block;
}
.celltoolbar select:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.celltoolbar select::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.celltoolbar select:-ms-input-placeholder {
  color: #999;
}
.celltoolbar select::-webkit-input-placeholder {
  color: #999;
}
.celltoolbar select::-ms-expand {
  border: 0;
  background-color: transparent;
}
.celltoolbar select[disabled],
.celltoolbar select[readonly],
fieldset[disabled] .celltoolbar select {
  background-color: #eeeeee;
  opacity: 1;
}
.celltoolbar select[disabled],
fieldset[disabled] .celltoolbar select {
  cursor: not-allowed;
}
textarea.celltoolbar select {
  height: auto;
}
select.celltoolbar select {
  height: 30px;
  line-height: 30px;
}
textarea.celltoolbar select,
select[multiple].celltoolbar select {
  height: auto;
}
.celltoolbar label {
  margin-left: 5px;
  margin-right: 5px;
}
.tags_button_container {
  width: 100%;
  display: flex;
}
.tag-container {
  display: flex;
  flex-direction: row;
  flex-grow: 1;
  overflow: hidden;
  position: relative;
}
.tag-container > * {
  margin: 0 4px;
}
.remove-tag-btn {
  margin-left: 4px;
}
.tags-input {
  display: flex;
}
.cell-tag:last-child:after {
  content: "";
  position: absolute;
  right: 0;
  width: 40px;
  height: 100%;
  /* Fade to background color of cell toolbar */
  background: linear-gradient(to right, rgba(0, 0, 0, 0), #EEE);
}
.tags-input > * {
  margin-left: 4px;
}
.cell-tag,
.tags-input input,
.tags-input button {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
  box-shadow: none;
  width: inherit;
  font-size: inherit;
  height: 22px;
  line-height: 22px;
  padding: 0px 4px;
  display: inline-block;
}
.cell-tag:focus,
.tags-input input:focus,
.tags-input button:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.cell-tag::-moz-placeholder,
.tags-input input::-moz-placeholder,
.tags-input button::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.cell-tag:-ms-input-placeholder,
.tags-input input:-ms-input-placeholder,
.tags-input button:-ms-input-placeholder {
  color: #999;
}
.cell-tag::-webkit-input-placeholder,
.tags-input input::-webkit-input-placeholder,
.tags-input button::-webkit-input-placeholder {
  color: #999;
}
.cell-tag::-ms-expand,
.tags-input input::-ms-expand,
.tags-input button::-ms-expand {
  border: 0;
  background-color: transparent;
}
.cell-tag[disabled],
.tags-input input[disabled],
.tags-input button[disabled],
.cell-tag[readonly],
.tags-input input[readonly],
.tags-input button[readonly],
fieldset[disabled] .cell-tag,
fieldset[disabled] .tags-input input,
fieldset[disabled] .tags-input button {
  background-color: #eeeeee;
  opacity: 1;
}
.cell-tag[disabled],
.tags-input input[disabled],
.tags-input button[disabled],
fieldset[disabled] .cell-tag,
fieldset[disabled] .tags-input input,
fieldset[disabled] .tags-input button {
  cursor: not-allowed;
}
textarea.cell-tag,
textarea.tags-input input,
textarea.tags-input button {
  height: auto;
}
select.cell-tag,
select.tags-input input,
select.tags-input button {
  height: 30px;
  line-height: 30px;
}
textarea.cell-tag,
textarea.tags-input input,
textarea.tags-input button,
select[multiple].cell-tag,
select[multiple].tags-input input,
select[multiple].tags-input button {
  height: auto;
}
.cell-tag,
.tags-input button {
  padding: 0px 4px;
}
.cell-tag {
  background-color: #fff;
  white-space: nowrap;
}
.tags-input input[type=text]:focus {
  outline: none;
  box-shadow: none;
  border-color: #ccc;
}
.completions {
  position: absolute;
  z-index: 110;
  overflow: hidden;
  border: 1px solid #ababab;
  border-radius: 2px;
  -webkit-box-shadow: 0px 6px 10px -1px #adadad;
  box-shadow: 0px 6px 10px -1px #adadad;
  line-height: 1;
}
.completions select {
  background: white;
  outline: none;
  border: none;
  padding: 0px;
  margin: 0px;
  overflow: auto;
  font-family: monospace;
  font-size: 110%;
  color: #000;
  width: auto;
}
.completions select option.context {
  color: #286090;
}
#kernel_logo_widget .current_kernel_logo {
  display: none;
  margin-top: -1px;
  margin-bottom: -1px;
  width: 32px;
  height: 32px;
}
[dir="rtl"] #kernel_logo_widget {
  float: left !important;
  float: left;
}
.modal .modal-body .move-path {
  display: flex;
  flex-direction: row;
  justify-content: space;
  align-items: center;
}
.modal .modal-body .move-path .server-root {
  padding-right: 20px;
}
.modal .modal-body .move-path .path-input {
  flex: 1;
}
#menubar {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  margin-top: 1px;
}
#menubar .navbar {
  border-top: 1px;
  border-radius: 0px 0px 2px 2px;
  margin-bottom: 0px;
}
#menubar .navbar-toggle {
  float: left;
  padding-top: 7px;
  padding-bottom: 7px;
  border: none;
}
#menubar .navbar-collapse {
  clear: left;
}
[dir="rtl"] #menubar .navbar-toggle {
  float: right;
}
[dir="rtl"] #menubar .navbar-collapse {
  clear: right;
}
[dir="rtl"] #menubar .navbar-nav {
  float: right;
}
[dir="rtl"] #menubar .nav {
  padding-right: 0px;
}
[dir="rtl"] #menubar .navbar-nav > li {
  float: right;
}
[dir="rtl"] #menubar .navbar-right {
  float: left !important;
}
[dir="rtl"] ul.dropdown-menu {
  text-align: right;
  left: auto;
}
[dir="rtl"] ul#new-menu.dropdown-menu {
  right: auto;
  left: 0;
}
.nav-wrapper {
  border-bottom: 1px solid #e7e7e7;
}
i.menu-icon {
  padding-top: 4px;
}
[dir="rtl"] i.menu-icon.pull-right {
  float: left !important;
  float: left;
}
ul#help_menu li a {
  overflow: hidden;
  padding-right: 2.2em;
}
ul#help_menu li a i {
  margin-right: -1.2em;
}
[dir="rtl"] ul#help_menu li a {
  padding-left: 2.2em;
}
[dir="rtl"] ul#help_menu li a i {
  margin-right: 0;
  margin-left: -1.2em;
}
[dir="rtl"] ul#help_menu li a i.pull-right {
  float: left !important;
  float: left;
}
.dropdown-submenu {
  position: relative;
}
.dropdown-submenu > .dropdown-menu {
  top: 0;
  left: 100%;
  margin-top: -6px;
  margin-left: -1px;
}
[dir="rtl"] .dropdown-submenu > .dropdown-menu {
  right: 100%;
  margin-right: -1px;
}
.dropdown-submenu:hover > .dropdown-menu {
  display: block;
}
.dropdown-submenu > a:after {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  display: block;
  content: "\f0da";
  float: right;
  color: #333333;
  margin-top: 2px;
  margin-right: -10px;
}
.dropdown-submenu > a:after.fa-pull-left {
  margin-right: .3em;
}
.dropdown-submenu > a:after.fa-pull-right {
  margin-left: .3em;
}
.dropdown-submenu > a:after.pull-left {
  margin-right: .3em;
}
.dropdown-submenu > a:after.pull-right {
  margin-left: .3em;
}
[dir="rtl"] .dropdown-submenu > a:after {
  float: left;
  content: "\f0d9";
  margin-right: 0;
  margin-left: -10px;
}
.dropdown-submenu:hover > a:after {
  color: #262626;
}
.dropdown-submenu.pull-left {
  float: none;
}
.dropdown-submenu.pull-left > .dropdown-menu {
  left: -100%;
  margin-left: 10px;
}
#notification_area {
  float: right !important;
  float: right;
  z-index: 10;
}
[dir="rtl"] #notification_area {
  float: left !important;
  float: left;
}
.indicator_area {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
[dir="rtl"] .indicator_area {
  float: left !important;
  float: left;
}
#kernel_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  border-left: 1px solid;
}
#kernel_indicator .kernel_indicator_name {
  padding-left: 5px;
  padding-right: 5px;
}
[dir="rtl"] #kernel_indicator {
  float: left !important;
  float: left;
  border-left: 0;
  border-right: 1px solid;
}
#modal_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
[dir="rtl"] #modal_indicator {
  float: left !important;
  float: left;
}
#readonly-indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  margin-top: 2px;
  margin-bottom: 0px;
  margin-left: 0px;
  margin-right: 0px;
  display: none;
}
.modal_indicator:before {
  width: 1.28571429em;
  text-align: center;
}
.edit_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f040";
}
.edit_mode .modal_indicator:before.fa-pull-left {
  margin-right: .3em;
}
.edit_mode .modal_indicator:before.fa-pull-right {
  margin-left: .3em;
}
.edit_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.edit_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.command_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: ' ';
}
.command_mode .modal_indicator:before.fa-pull-left {
  margin-right: .3em;
}
.command_mode .modal_indicator:before.fa-pull-right {
  margin-left: .3em;
}
.command_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.command_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.kernel_idle_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f10c";
}
.kernel_idle_icon:before.fa-pull-left {
  margin-right: .3em;
}
.kernel_idle_icon:before.fa-pull-right {
  margin-left: .3em;
}
.kernel_idle_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_idle_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_busy_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f111";
}
.kernel_busy_icon:before.fa-pull-left {
  margin-right: .3em;
}
.kernel_busy_icon:before.fa-pull-right {
  margin-left: .3em;
}
.kernel_busy_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_busy_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_dead_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f1e2";
}
.kernel_dead_icon:before.fa-pull-left {
  margin-right: .3em;
}
.kernel_dead_icon:before.fa-pull-right {
  margin-left: .3em;
}
.kernel_dead_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_dead_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_disconnected_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f127";
}
.kernel_disconnected_icon:before.fa-pull-left {
  margin-right: .3em;
}
.kernel_disconnected_icon:before.fa-pull-right {
  margin-left: .3em;
}
.kernel_disconnected_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_disconnected_icon:before.pull-right {
  margin-left: .3em;
}
.notification_widget {
  color: #777;
  z-index: 10;
  background: rgba(240, 240, 240, 0.5);
  margin-right: 4px;
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget:focus,
.notification_widget.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.notification_widget:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active:hover,
.notification_widget.active:hover,
.open > .dropdown-toggle.notification_widget:hover,
.notification_widget:active:focus,
.notification_widget.active:focus,
.open > .dropdown-toggle.notification_widget:focus,
.notification_widget:active.focus,
.notification_widget.active.focus,
.open > .dropdown-toggle.notification_widget.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  background-image: none;
}
.notification_widget.disabled:hover,
.notification_widget[disabled]:hover,
fieldset[disabled] .notification_widget:hover,
.notification_widget.disabled:focus,
.notification_widget[disabled]:focus,
fieldset[disabled] .notification_widget:focus,
.notification_widget.disabled.focus,
.notification_widget[disabled].focus,
fieldset[disabled] .notification_widget.focus {
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget .badge {
  color: #fff;
  background-color: #333;
}
.notification_widget.warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning:focus,
.notification_widget.warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.notification_widget.warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active:hover,
.notification_widget.warning.active:hover,
.open > .dropdown-toggle.notification_widget.warning:hover,
.notification_widget.warning:active:focus,
.notification_widget.warning.active:focus,
.open > .dropdown-toggle.notification_widget.warning:focus,
.notification_widget.warning:active.focus,
.notification_widget.warning.active.focus,
.open > .dropdown-toggle.notification_widget.warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  background-image: none;
}
.notification_widget.warning.disabled:hover,
.notification_widget.warning[disabled]:hover,
fieldset[disabled] .notification_widget.warning:hover,
.notification_widget.warning.disabled:focus,
.notification_widget.warning[disabled]:focus,
fieldset[disabled] .notification_widget.warning:focus,
.notification_widget.warning.disabled.focus,
.notification_widget.warning[disabled].focus,
fieldset[disabled] .notification_widget.warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.notification_widget.success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success:focus,
.notification_widget.success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.notification_widget.success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active:hover,
.notification_widget.success.active:hover,
.open > .dropdown-toggle.notification_widget.success:hover,
.notification_widget.success:active:focus,
.notification_widget.success.active:focus,
.open > .dropdown-toggle.notification_widget.success:focus,
.notification_widget.success:active.focus,
.notification_widget.success.active.focus,
.open > .dropdown-toggle.notification_widget.success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  background-image: none;
}
.notification_widget.success.disabled:hover,
.notification_widget.success[disabled]:hover,
fieldset[disabled] .notification_widget.success:hover,
.notification_widget.success.disabled:focus,
.notification_widget.success[disabled]:focus,
fieldset[disabled] .notification_widget.success:focus,
.notification_widget.success.disabled.focus,
.notification_widget.success[disabled].focus,
fieldset[disabled] .notification_widget.success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.notification_widget.info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info:focus,
.notification_widget.info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.notification_widget.info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active:hover,
.notification_widget.info.active:hover,
.open > .dropdown-toggle.notification_widget.info:hover,
.notification_widget.info:active:focus,
.notification_widget.info.active:focus,
.open > .dropdown-toggle.notification_widget.info:focus,
.notification_widget.info:active.focus,
.notification_widget.info.active.focus,
.open > .dropdown-toggle.notification_widget.info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  background-image: none;
}
.notification_widget.info.disabled:hover,
.notification_widget.info[disabled]:hover,
fieldset[disabled] .notification_widget.info:hover,
.notification_widget.info.disabled:focus,
.notification_widget.info[disabled]:focus,
fieldset[disabled] .notification_widget.info:focus,
.notification_widget.info.disabled.focus,
.notification_widget.info[disabled].focus,
fieldset[disabled] .notification_widget.info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.notification_widget.danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger:focus,
.notification_widget.danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.notification_widget.danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active:hover,
.notification_widget.danger.active:hover,
.open > .dropdown-toggle.notification_widget.danger:hover,
.notification_widget.danger:active:focus,
.notification_widget.danger.active:focus,
.open > .dropdown-toggle.notification_widget.danger:focus,
.notification_widget.danger:active.focus,
.notification_widget.danger.active.focus,
.open > .dropdown-toggle.notification_widget.danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  background-image: none;
}
.notification_widget.danger.disabled:hover,
.notification_widget.danger[disabled]:hover,
fieldset[disabled] .notification_widget.danger:hover,
.notification_widget.danger.disabled:focus,
.notification_widget.danger[disabled]:focus,
fieldset[disabled] .notification_widget.danger:focus,
.notification_widget.danger.disabled.focus,
.notification_widget.danger[disabled].focus,
fieldset[disabled] .notification_widget.danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger .badge {
  color: #d9534f;
  background-color: #fff;
}
div#pager {
  background-color: #fff;
  font-size: 14px;
  line-height: 20px;
  overflow: hidden;
  display: none;
  position: fixed;
  bottom: 0px;
  width: 100%;
  max-height: 50%;
  padding-top: 8px;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  /* Display over codemirror */
  z-index: 100;
  /* Hack which prevents jquery ui resizable from changing top. */
  top: auto !important;
}
div#pager pre {
  line-height: 1.21429em;
  color: #000;
  background-color: #f7f7f7;
  padding: 0.4em;
}
div#pager #pager-button-area {
  position: absolute;
  top: 8px;
  right: 20px;
}
div#pager #pager-contents {
  position: relative;
  overflow: auto;
  width: 100%;
  height: 100%;
}
div#pager #pager-contents #pager-container {
  position: relative;
  padding: 15px 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
div#pager .ui-resizable-handle {
  top: 0px;
  height: 8px;
  background: #f7f7f7;
  border-top: 1px solid #cfcfcf;
  border-bottom: 1px solid #cfcfcf;
  /* This injects handle bars (a short, wide = symbol) for 
        the resize handle. */
}
div#pager .ui-resizable-handle::after {
  content: '';
  top: 2px;
  left: 50%;
  height: 3px;
  width: 30px;
  margin-left: -15px;
  position: absolute;
  border-top: 1px solid #cfcfcf;
}
.quickhelp {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  line-height: 1.8em;
}
.shortcut_key {
  display: inline-block;
  width: 21ex;
  text-align: right;
  font-family: monospace;
}
.shortcut_descr {
  display: inline-block;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
span.save_widget {
  height: 30px;
  margin-top: 4px;
  display: flex;
  justify-content: flex-start;
  align-items: baseline;
  width: 50%;
  flex: 1;
}
span.save_widget span.filename {
  height: 100%;
  line-height: 1em;
  margin-left: 16px;
  border: none;
  font-size: 146.5%;
  text-overflow: ellipsis;
  overflow: hidden;
  white-space: nowrap;
  border-radius: 2px;
}
span.save_widget span.filename:hover {
  background-color: #e6e6e6;
}
[dir="rtl"] span.save_widget.pull-left {
  float: right !important;
  float: right;
}
[dir="rtl"] span.save_widget span.filename {
  margin-left: 0;
  margin-right: 16px;
}
span.checkpoint_status,
span.autosave_status {
  font-size: small;
  white-space: nowrap;
  padding: 0 5px;
}
@media (max-width: 767px) {
  span.save_widget {
    font-size: small;
    padding: 0 0 0 5px;
  }
  span.checkpoint_status,
  span.autosave_status {
    display: none;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  span.checkpoint_status {
    display: none;
  }
  span.autosave_status {
    font-size: x-small;
  }
}
.toolbar {
  padding: 0px;
  margin-left: -5px;
  margin-top: 2px;
  margin-bottom: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.toolbar select,
.toolbar label {
  width: auto;
  vertical-align: middle;
  margin-right: 2px;
  margin-bottom: 0px;
  display: inline;
  font-size: 92%;
  margin-left: 0.3em;
  margin-right: 0.3em;
  padding: 0px;
  padding-top: 3px;
}
.toolbar .btn {
  padding: 2px 8px;
}
.toolbar .btn-group {
  margin-top: 0px;
  margin-left: 5px;
}
.toolbar-btn-label {
  margin-left: 6px;
}
#maintoolbar {
  margin-bottom: -3px;
  margin-top: -8px;
  border: 0px;
  min-height: 27px;
  margin-left: 0px;
  padding-top: 11px;
  padding-bottom: 3px;
}
#maintoolbar .navbar-text {
  float: none;
  vertical-align: middle;
  text-align: right;
  margin-left: 5px;
  margin-right: 0px;
  margin-top: 0px;
}
.select-xs {
  height: 24px;
}
[dir="rtl"] .btn-group > .btn,
.btn-group-vertical > .btn {
  float: right;
}
.pulse,
.dropdown-menu > li > a.pulse,
li.pulse > a.dropdown-toggle,
li.pulse.open > a.dropdown-toggle {
  background-color: #F37626;
  color: white;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
/** WARNING IF YOU ARE EDITTING THIS FILE, if this is a .css file, It has a lot
 * of chance of beeing generated from the ../less/[samename].less file, you can
 * try to get back the less file by reverting somme commit in history
 **/
/*
 * We'll try to get something pretty, so we
 * have some strange css to have the scroll bar on
 * the left with fix button on the top right of the tooltip
 */
@-moz-keyframes fadeOut {
  from {
    opacity: 1;
  }
  to {
    opacity: 0;
  }
}
@-webkit-keyframes fadeOut {
  from {
    opacity: 1;
  }
  to {
    opacity: 0;
  }
}
@-moz-keyframes fadeIn {
  from {
    opacity: 0;
  }
  to {
    opacity: 1;
  }
}
@-webkit-keyframes fadeIn {
  from {
    opacity: 0;
  }
  to {
    opacity: 1;
  }
}
/*properties of tooltip after "expand"*/
.bigtooltip {
  overflow: auto;
  height: 200px;
  -webkit-transition-property: height;
  -webkit-transition-duration: 500ms;
  -moz-transition-property: height;
  -moz-transition-duration: 500ms;
  transition-property: height;
  transition-duration: 500ms;
}
/*properties of tooltip before "expand"*/
.smalltooltip {
  -webkit-transition-property: height;
  -webkit-transition-duration: 500ms;
  -moz-transition-property: height;
  -moz-transition-duration: 500ms;
  transition-property: height;
  transition-duration: 500ms;
  text-overflow: ellipsis;
  overflow: hidden;
  height: 80px;
}
.tooltipbuttons {
  position: absolute;
  padding-right: 15px;
  top: 0px;
  right: 0px;
}
.tooltiptext {
  /*avoid the button to overlap on some docstring*/
  padding-right: 30px;
}
.ipython_tooltip {
  max-width: 700px;
  /*fade-in animation when inserted*/
  -webkit-animation: fadeOut 400ms;
  -moz-animation: fadeOut 400ms;
  animation: fadeOut 400ms;
  -webkit-animation: fadeIn 400ms;
  -moz-animation: fadeIn 400ms;
  animation: fadeIn 400ms;
  vertical-align: middle;
  background-color: #f7f7f7;
  overflow: visible;
  border: #ababab 1px solid;
  outline: none;
  padding: 3px;
  margin: 0px;
  padding-left: 7px;
  font-family: monospace;
  min-height: 50px;
  -moz-box-shadow: 0px 6px 10px -1px #adadad;
  -webkit-box-shadow: 0px 6px 10px -1px #adadad;
  box-shadow: 0px 6px 10px -1px #adadad;
  border-radius: 2px;
  position: absolute;
  z-index: 1000;
}
.ipython_tooltip a {
  float: right;
}
.ipython_tooltip .tooltiptext pre {
  border: 0;
  border-radius: 0;
  font-size: 100%;
  background-color: #f7f7f7;
}
.pretooltiparrow {
  left: 0px;
  margin: 0px;
  top: -16px;
  width: 40px;
  height: 16px;
  overflow: hidden;
  position: absolute;
}
.pretooltiparrow:before {
  background-color: #f7f7f7;
  border: 1px #ababab solid;
  z-index: 11;
  content: "";
  position: absolute;
  left: 15px;
  top: 10px;
  width: 25px;
  height: 25px;
  -webkit-transform: rotate(45deg);
  -moz-transform: rotate(45deg);
  -ms-transform: rotate(45deg);
  -o-transform: rotate(45deg);
}
ul.typeahead-list i {
  margin-left: -10px;
  width: 18px;
}
[dir="rtl"] ul.typeahead-list i {
  margin-left: 0;
  margin-right: -10px;
}
ul.typeahead-list {
  max-height: 80vh;
  overflow: auto;
}
ul.typeahead-list > li > a {
  /** Firefox bug **/
  /* see https://github.com/jupyter/notebook/issues/559 */
  white-space: normal;
}
ul.typeahead-list  > li > a.pull-right {
  float: left !important;
  float: left;
}
[dir="rtl"] .typeahead-list {
  text-align: right;
}
.cmd-palette .modal-body {
  padding: 7px;
}
.cmd-palette form {
  background: white;
}
.cmd-palette input {
  outline: none;
}
.no-shortcut {
  min-width: 20px;
  color: transparent;
}
[dir="rtl"] .no-shortcut.pull-right {
  float: left !important;
  float: left;
}
[dir="rtl"] .command-shortcut.pull-right {
  float: left !important;
  float: left;
}
.command-shortcut:before {
  content: "(command mode)";
  padding-right: 3px;
  color: #777777;
}
.edit-shortcut:before {
  content: "(edit)";
  padding-right: 3px;
  color: #777777;
}
[dir="rtl"] .edit-shortcut.pull-right {
  float: left !important;
  float: left;
}
#find-and-replace #replace-preview .match,
#find-and-replace #replace-preview .insert {
  background-color: #BBDEFB;
  border-color: #90CAF9;
  border-style: solid;
  border-width: 1px;
  border-radius: 0px;
}
[dir="ltr"] #find-and-replace .input-group-btn + .form-control {
  border-left: none;
}
[dir="rtl"] #find-and-replace .input-group-btn + .form-control {
  border-right: none;
}
#find-and-replace #replace-preview .replace .match {
  background-color: #FFCDD2;
  border-color: #EF9A9A;
  border-radius: 0px;
}
#find-and-replace #replace-preview .replace .insert {
  background-color: #C8E6C9;
  border-color: #A5D6A7;
  border-radius: 0px;
}
#find-and-replace #replace-preview {
  max-height: 60vh;
  overflow: auto;
}
#find-and-replace #replace-preview pre {
  padding: 5px 10px;
}
.terminal-app {
  background: #EEE;
}
.terminal-app #header {
  background: #fff;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
.terminal-app .terminal {
  width: 100%;
  float: left;
  font-family: monospace;
  color: white;
  background: black;
  padding: 0.4em;
  border-radius: 2px;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.4);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.4);
}
.terminal-app .terminal,
.terminal-app .terminal dummy-screen {
  line-height: 1em;
  font-size: 14px;
}
.terminal-app .terminal .xterm-rows {
  padding: 10px;
}
.terminal-app .terminal-cursor {
  color: black;
  background: white;
}
.terminal-app #terminado-container {
  margin-top: 20px;
}
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.highlight  { background: #f8f8f8; }
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.highlight .cm { color: #408080; font-style: italic } /* Comment.Multiline */
.highlight .cp { color: #BC7A00 } /* Comment.Preproc */
.highlight .cpf { color: #408080; font-style: italic } /* Comment.PreprocFile */
.highlight .c1 { color: #408080; font-style: italic } /* Comment.Single */
.highlight .cs { color: #408080; font-style: italic } /* Comment.Special */
.highlight .gd { color: #A00000 } /* Generic.Deleted */
.highlight .ge { font-style: italic } /* Generic.Emph */
.highlight .gr { color: #FF0000 } /* Generic.Error */
.highlight .gh { color: #000080; font-weight: bold } /* Generic.Heading */
.highlight .gi { color: #00A000 } /* Generic.Inserted */
.highlight .go { color: #888888 } /* Generic.Output */
.highlight .gp { color: #000080; font-weight: bold } /* Generic.Prompt */
.highlight .gs { font-weight: bold } /* Generic.Strong */
.highlight .gu { color: #800080; font-weight: bold } /* Generic.Subheading */
.highlight .gt { color: #0044DD } /* Generic.Traceback */
.highlight .kc { color: #008000; font-weight: bold } /* Keyword.Constant */
.highlight .kd { color: #008000; font-weight: bold } /* Keyword.Declaration */
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<style type="text/css">
/* Overrides of notebook CSS for static HTML export */
body {
  overflow: visible;
  padding: 8px;
}

div#notebook {
  overflow: visible;
  border-top: none;
}@media print {
  div.cell {
    display: block;
    page-break-inside: avoid;
  } 
  div.output_wrapper { 
    display: block;
    page-break-inside: avoid; 
  }
  div.output { 
    display: block;
    page-break-inside: avoid; 
  }
}
</style>

<!-- Custom stylesheet, it must be in the same directory as the html file -->
<link rel="stylesheet" href="custom.css">

<!-- Loading mathjax macro -->
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    <script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/latest.js?config=TeX-AMS_HTML"></script>
    <!-- MathJax configuration -->
    <script type="text/x-mathjax-config">
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        displayAlign: 'center',
        "HTML-CSS": {
            styles: {'.MathJax_Display': {"margin": 0}},
            linebreaks: { automatic: true }
        }
    });
    </script>
    <!-- End of mathjax configuration --></head>
<body>
  <div tabindex="-1" id="notebook" class="border-box-sizing">
    <div class="container" id="notebook-container">

<div class="cell border-box-sizing code_cell rendered">
<div class="input">
<div class="prompt input_prompt">In&nbsp;[1]:</div>
<div class="inner_cell">
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<div class=" highlight hl-ipython3"><pre><span></span><span class="kn">from</span> <span class="nn">IPython.core.display</span> <span class="k">import</span> <span class="n">display</span><span class="p">,</span> <span class="n">HTML</span>
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<h2 id="Simulation-des-donn&#233;es-d&#233;mographiques-et-g&#233;nomiques-de-deux-sous-populations-structur&#233;es-en-&#226;ge-et-interconnect&#233;es-par-des-flux-de-g&#232;nes">Simulation des donn&#233;es d&#233;mographiques et g&#233;nomiques de deux sous-populations structur&#233;es en &#226;ge et interconnect&#233;es par des flux de g&#232;nes<a class="anchor-link" href="#Simulation-des-donn&#233;es-d&#233;mographiques-et-g&#233;nomiques-de-deux-sous-populations-structur&#233;es-en-&#226;ge-et-interconnect&#233;es-par-des-flux-de-g&#232;nes">&#182;</a></h2><h3 id="Projet-POPSIZE-(IRD-UMR-Marbec,-CRPMEM-de-La-R&#233;union,-projet-FEAMP-Mesure-28)">Projet POPSIZE (IRD UMR Marbec, CRPMEM de La R&#233;union, projet FEAMP Mesure 28)<a class="anchor-link" href="#Projet-POPSIZE-(IRD-UMR-Marbec,-CRPMEM-de-La-R&#233;union,-projet-FEAMP-Mesure-28)">&#182;</a></h3><h3 id="Delord,-C.---Juin-2023">Delord, C. - Juin 2023<a class="anchor-link" href="#Delord,-C.---Juin-2023">&#182;</a></h3><h3 id="Objectif-:"><strong>Objectif</strong> :<a class="anchor-link" href="#Objectif-:">&#182;</a></h3><p>Dans le cadre du projet POPSIZE, nous nous intéressons à des populations de grands pélagiques marins. Nous nous plaçons ici dans un cadre relativement simple dans lequel on considère deux sous-populations théoriques structurées en âges, où chaque classe d'âge présente un taux de survie et de fécondité propre et identique entre mâles et femelles. Les deux sous-populations peuvent échanger des flux de gènes par voie de migration plus ou moins importante. Leur abondance, en nombre total d'individus, ainsi que leur structure en âges sont stables au cours du temps et identiques d'une sous-population à l'autre.</p>
<p>Nous souhaitons simuler les données démographiques et génétiques propres à ces deux sous-populations en tant que représentation simplifiée d'une espèce de top-prédateur à forte abondance et capacité de migration, le thon germon (<em>Thunnus alalunga</em>).</p>
<p>Ces données simulées, après post-traitement, seront utilisées pour évaluer la capacité de plusieurs méthodes à estimer l'abondance totale (taille census Nc) et la taille efficace (Ne) de telles populations, malgré leur forte abondance et la présence potentielle d'une sous-structuration génétique spatiale faible mais significative. Les méthodes testées sont diverses et peuvent s'appuyer (i) sur les spectres de fréquences alléliques (SFS), tels que les outils implémentés dans le logiciel moments (<a href="https://academic.oup.com/genetics/article/206/3/1549/6064248?login=true">Jouganous et al. 2018</a>) ou dadi (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760211/">Gutenkunst et al. 2011</a>]), (ii) sur le déséquilibre de liaison tels que les outils implémentés dans moments-LD (<a href="https://academic.oup.com/mbe/article/37/3/923/5614437?login=true">Ragsdale &amp; Gravel 2020</a>), NeEstimator2 (<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/1755-0998.12157">Do et al. 2014</a>) ou GONE (<a href="https://academic.oup.com/mbe/article/37/12/3642/5869049?login=true">Santiago et al. 2020</a>), ou encore (iii) sur des analyses d'apparentement telle que la méthode de <em>close-kin mark-recapture</em> (CKMR) (<a href="https://www.nespmarine.edu.au/system/files/Bravington%20et%20al%20Close%20kin%20mark%20recapture%20StatisticalScience_euclid.ss_.1464105042.pdf">Bravington et al. 2016</a>)).</p>
<p>Le présent document vise à fournir une description détaillée de la procédure de simulation développée pour obtenir des données démographiques et génétiques sur lesquelles nous pourrons ensuite tester ces différentes méthodes. Il s'attache à intégrer, dès que possible, des informations complémentaires via des liens URL menant vers des publications ou des forums d'échanges scientifiques afin de permettre d'aller plus loin. Pour plus d'informations ou en cas de question, ne pas hésiter à envoyer un e-mail à l'adresse suivante: chrys.delord@gmail.com.</p>

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<h3 id="Caract&#233;ristiques-des-sous-populations-simul&#233;es-:"><strong>Caract&#233;ristiques des sous-populations simul&#233;es</strong> :<a class="anchor-link" href="#Caract&#233;ristiques-des-sous-populations-simul&#233;es-:">&#182;</a></h3><p>Avant d'entrer dans les concepts théoriques et les aspects techniques de programmation, commençons tout d'abord par spécifier les caractéristiques démographiques et génétiques des populations que nous allons simuler.</p>
<p>Nos deux sous-populations présentent les caractéristiques suivantes:</p>
<ul>
<li>Les 2 sous-populations se composent chacune de ~17710 individus au total (paramètre <strong><em>K</em></strong>), dont 5000 nouveaux-nés (paramètre <strong><em>final_cohort_size</em></strong>) générés à chaque événement de reproduction. Ces effectifs sont stables dans le temps, donc d'un événement de reproduction au suivant. La structure en âge est fixée en début de simulation (paramètre vecteur <strong><em>W</em></strong>) et chaque classe d'âge se caractérise par une valeur de mortalité (paramètre vecteur <strong><em>L</em></strong>) et de fécondité relative (paramètre vecteur <strong><em>B</em></strong>). L'âge maximal est fixé à 15 ans (tout individu dépassant l'âge de 15 ans décède) et l'âge à maturité est fixé à 4 ans (tout individu de 4 ou plus peut se reproduire).</li>
<li>Les 2 sous-populations échangent une proportion continue et symétrique d'individus à chaque pas de temps, fixée à 5% (paramètre <strong><em>m</em></strong>). On considère donc des flux de gènes stables et homogènes (les effectifs des 2 sous-populations étant identiques) d'une sous-population à l'autre.</li>
<li>L'information génétique des individus est portée par 5 chromosomes indépendants de 4e08 paire de bases (400 Mbp) chacun, avec un taux de recombinaison classique fixé à 1e-08 par meiose et par paire de bases. Cela correspond à un génome d'une taille totale de 2.0 gigabases. Chacun des 5 chromosomes présente une longueur de 400 centimorgans si l'on raisonne en distance génétique. Ainsi, deux locus pris au hasard seront totalement indépendants s'ils proviennent de deux chromosomes distincts mais seront au contraire partiellement liés s'ils proviennent d'un même chromosome, comme cela est le cas pour un jeu de données réel à haute densité de marqueurs.</li>
</ul>
<h3 id="Choix-de-la-proc&#233;dure-de-simulation-:"><strong>Choix de la proc&#233;dure de simulation</strong> :<a class="anchor-link" href="#Choix-de-la-proc&#233;dure-de-simulation-:">&#182;</a></h3><p>Les sous-populations simulées sont structurées en âge afin de se rapprocher de la réalité biologique de la plupart des espèces de grands pélagiques, qui présentent en effet des générations chevauchantes. Pour simuler cette réalité biologique, les outils de simulation individu-centrés sont nécessaires (par opposition à des outils de simulation échantillon- ou population-centrés tels que ceux qui s'appuient sur le coalescent). Nous avons fait le choix d'utiliser le logiciel de simulation individu-centré <a href="https://messerlab.org/slim/">SLiM</a>. Au moment d'initialiser la simulation, nous spécifierons que les populations simulées ne s'appuiront pas sur une approximation du modèle de population de Wright-Fisher (contrairement à ce que proposent les outils de simulation basés sur le coalescent), en activant la fonctionnalité <strong><em>nonWF</em></strong>. Les outils de simulation individu-centrés ont l'avantage de permettre la simulation de populations biologiquement réalistes, mais présentent l'inconvénient de nécessiter un temps de calcul très long et d'utiliser beaucoup de mémoire vive et de mémoire de stockage, puisque chaque individu est modélisé distinctement des autres.</p>
<p>Le logiciel SLiM permet d'extraire, de chaque simulation, des informations démographiques et généalogiques diverses sur tout ou partie des individus simulés. On peut ainsi échantillonner une partie de ces individus selon des critères que l'on choisit (par exemple, on échantillonne au hasard 50 individus dans chaque classe d'âge et dans chaque sous-population), et consigner par exemple leur âge et leur sexe mais aussi leurs relations d'apparentements avec d'autres individus issus de la même simulation, par exemple. En outre, l'activation de la fonctionnalité de <strong>tree-sequence recording</strong>, un élément-clé dont nous reparlerons plus tard, permet également de consigner les généalogies de gènes au sein de l'échantillon.</p>
<p>Au delà d'une information démographique réaliste, nous souhaitons simuler l'information génomique relative aux individus présents dans nos sous-populations (notamment sous forme de génotypes pour un certain nombre de loci dont les positions relatives sur le génome sont connues). SLiM peut générer tout ou partie de cette information en simulant des chromosomes porteurs ou non de variabilité génétique, néanmoins, cette procédure augmente très considérablement le temps de calcul. La fonctionnalité de <strong>tree-sequence recording</strong> entre alors en jeu. Dans le cas où seule la variabilité génétique neutre nous intéresse (et dépend donc uniquement de forces évolutives neutres et non pas, a priori, de la fitness des individus simulés), il est possible de s'affranchir de la nécessité de simuler cette variabilité génétique neutre avec SLiM, et donc de gagner du temps. Seule une généalogie de gènes, occasionnée par les différents événements de reproduction et de recombinaison au cours du temps, sera exportée à l'issue de la simulation, sous-forme de <strong>tree sequence</strong>. Ce <strong>tree sequence</strong> peut alors être utilisé comme point de départ à une nouvelle étape de simulation plus classique, basée sur le coalescent, qui se chargera d'une part de compléter les généalogies si besoin en reconstituant leur trajectoire évolutive passée, d'autre part d'y intégrer de la variabilité génétique neutre en fonction de leur topologie (pour plus de détails, consulter le rapport scientifique final du projet POPSIZE, section I.3.2).</p>
<p>Les librairies Python <em><a href="https://tskit.dev/tutorials/intro.html">tskit</a></em> et <em><a href="https://tskit.dev/pyslim/docs/stable/introduction.html">pyslim</a></em> permettent de faire le lien entre les informations portées par un fichier <strong>tree sequence</strong> issu du logiciel SLiM d'une part, et la librairie Python <em><a href="https://tskit.dev/msprime/docs/stable/intro.html">msprime</a></em> d'autre part. Cette dernière permet la réalisation de simulations basées sur plusieurs modèles de coalescence et donc, de simuler rapidement les trajectoires évolutives passées et présentes de populations de Wright-Fisher ainsi que leur diversité génétique associée. La combinaison de SLiM et <em>msprime</em> permet d'associer les avantages respectifs des approches individu-centrées et de coalescence : le réalisme biologique d'une part et la reconstitution de trajectoires évolutives passées d'autre part, le tout en une durée optimisée (qui peut néanmoins rester très longue dans le cadre de la simulation d'information génomique pour de grandes populations).</p>
<p><strong>Le présent document contiendra ainsi des sections de code rédigées via le langage Eidos spécifique à SLiM, mais également des sections rédigées en langage Python pour ce qui concerne l'utilisation des librairies <em>pyslim</em> et <em>msprime</em>.</strong></p>

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<h3 id="Pr&#233;-requis-:"><strong>Pr&#233;-requis</strong> :<a class="anchor-link" href="#Pr&#233;-requis-:">&#182;</a></h3><p>Afin de ré-effectuer ces simulations, il est indispensable d'installer les librairies et logiciels suivants (si possible en utilisant Anaconda) :</p>
<ul>
<li>SLiM version 3.7</li>
<li>Python3 avec les librairies <em>demesdraw</em>, <em>math</em>, <em>matplotlib.pyplot</em>, <em>msprime</em>, <em>numpy</em>, <em>pandas</em>, <em>pyslim</em> et <em>tskit</em>.</li>
<li>R version &gt;= 4.0.5 avec les libraries <em>CKMRpop</em>, <em>dartR</em>, <em>psych</em> and <em>tidyverse</em> et toutes leurs dépendances.</li>
</ul>
<h3 id="Disclaimer-:"><strong>Disclaimer</strong> :<a class="anchor-link" href="#Disclaimer-:">&#182;</a></h3><p>Les sections de code ci-dessous, bien que revues par les développeurs des logiciels SLiM et <em>msprime</em>, n'ont pas vocation à constituer une manière unique de simuler les données attendues. Elles peuvent également se révéler sous-optimales en termes de vitesse et de gestion de la mémoire. En outre, les fonctionnalités des logiciels SLiM, <em>pyslim</em> et <em>msprime</em> évoluant très rapidement, il est possible que la syntaxe de certaines lignes devienne obsolète avec le temps. Enfin, l'ensemble des sections de code présentées ci-dessous s'inspire d'exemples trouvés en divers lieux et places dans la littérature scientifique et technique. Nous nous sommes attachés à citer autant de références et de sources que possible et espérons n'en avoir oublié aucune. Nous remercions chaleureusement Jérôme Kelleher, Peter Ralph et Ben Haller pour leur travail de maintenance et d'animation des groupes d'entraide liés à <a href="https://groups.google.com/g/slim-discuss">SLiM</a> et <em><a href="https://github.com/tskit-dev/pyslim/issues">pyslim/msprime</a></em>.</p>

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<h2 id="Etape-n&#176;1.">Etape n&#176;1.<a class="anchor-link" href="#Etape-n&#176;1.">&#182;</a></h2><h2 id="Simulation-de-l'histoire-contemporaine-des-sous-populations-&#224;-l'aide-d'une-approche-individu-centr&#233;e-:">Simulation de l'histoire contemporaine des sous-populations &#224; l'aide d'une approche individu-centr&#233;e :<a class="anchor-link" href="#Simulation-de-l'histoire-contemporaine-des-sous-populations-&#224;-l'aide-d'une-approche-individu-centr&#233;e-:">&#182;</a></h2><h3 id="SLiM-ver.-3.7">SLiM ver. 3.7<a class="anchor-link" href="#SLiM-ver.-3.7">&#182;</a></h3><p>Nous commençons par exécuter le script Eidos dans notre console Anaconda à l'aide de la commande <code>slim POPSIZE_SLiM_Cohort5000_m005.txt &gt; output_POPSIZE_SLiM_Cohort5000_m005.txt</code>.</p>
<p>Le script <code>POPSIZE_SLiM_Cohort5000_m005.txt</code> s'écrit comme suit. Nous allons découper ce fichier en plusieurs parties afin d'en faciliter la lecture et la compréhension.</p>
<p>Notre script débute par quelques lignes commentées (débutant par un double-slash //) fournissant des informations et des références. Puis, nous devons définir certaines des fonctionnalités de la simulation. Enfin, nous initialisons des fichiers texte de sortie dans lequels plusieurs informations démographiques seront stockées à chaque pas de temps simulé.</p>
<p>Script <code>POPSIZE_SLiM_Cohort5000_m005.txt</code> <strong>(Partie 1/4)</strong></p>

<pre><code>// Ce script Eidos vise à simuler 2 sous-populations de type "nonWF" (non Wright-Fisher), structurées en âges et échangeant des flux de gènes durant 100 pas de temps (événements de reproduction) en utilisant SLiM37 avec les fonctions 'pedigree tracking' et 'tree sequence recording'.
// Il vise égaement à générer des fichiers de sortie contenant des informations diverses sur les individus simulés. Ces fichiers sont construits sur le même modèle que ceux générés par le simulateur Spip et la librairie R CKMRpop (Anderson 2022, https://doi.org/10.1111/1755-0998.13513).
// Ce script effectue un échantillonnage en série ('serial sampling') avec la fonction 'treeSeqRememberIndividuals()'.
// Les lignes de codes rédigées s'inspirent essentiellement des sources suivantes :
//     - la vignette CKMRpop : https://eriqande.github.io/CKMRpop/articles/using-other-simulation-programs.html associés à la publication d'Anderson (2022) (https://doi.org/10.1111/1755-0998.13513).
//     - la 'SLiM recipe' 16.2 (Manuel d'utilisation SLiM màj 13 février 2022)
//     - la 'SLiM recipe' 16.5 (Manuel d'utilisation SLiM màj 13 février 2022)
//     - la section 4.1.6 du Manuel d'utilisation SLiM màj 13 février 2022) 
//     - la discussion: https://groups.google.com/g/slim-discuss/c/PaCARghZy9Q
//     - la vignette msprime: https://tskit.dev/msprime/docs/stable/ancestry.html?highlight=multiple#multiple-chromosomes

initialize() {

    setSeed(getSeed());    
    initializeSLiMModelType("nonWF"); // la simulation ne s'appuie pas sur les hypothèses d'une population de Wright-Fisher. Nous simulerons, notamment, des générations chevauchantes et non des générations discrètes.
    initializeSLiMOptions(keepPedigrees = T); // on active l'enregistrement du pedigree des individus.
    initializeTreeSeq(); // on active la fonctionnalité de tree-sequence recording.
    initializeSex("A"); // sexes séparés: les mâles et les femelles sont distincts.

    initializeMutationType("m1", 0.5, "f", 0.0);
    initializeGenomicElementType("g1", m1, 1.0); // un type unique et homogène d'élément génomique et de mutation.
    initializeGenomicElement(g1, 0, 1999999999); // un "chromosome" d'une taille de 2.0 gigabases.
    initializeMutationRate(0.0); // on ne simule aucune variabilité génétique à ce stade. Des mutations neutres seront incorporées lors de la phase de simulation pyslim/msprime.
    initializeRecombinationRate(c(1.0e-08, 0.5, 1.0e-08, 0.5, 1.0e-08, 0.5, 1.0e-08, 0.5, 1.0e-08), c(400000000, 400000001, 800000000, 800000001, 1200000000, 1200000001, 1600000000, 1600000001, 1999999999)); 
    // on découpe notre chromosome en 5 sections égales librement recombinantes (c.f 'SLiM recipe' 6.1.4)
    // le taux de recombinaison au sein de chaque section est de 1.0e-08.
    m1.convertToSubstitution = T;

    defineConstant("K", 17710); // abondance totale de chaque sous-population dès la génération 1 (incluant les nouveaux-nés), toutes classes d'âge confondues -cet effectif restera constant (à quelques individus près) au cours du temps.
    // on définit les taux de mortalité L et de fécondité relative B des classes d'âge de 0 à 15. Tous les individus d'âge zéro (nouveaux-nés) survivent jusqu'à l'âge 1:
    defineConstant("L", c(0.00, 0.46, 0.38, 0.34, 0.31, 0.29, 0.31, 0.34, 0.38, 0.44, 0.55, 0.55, 0.55, 0.55, 0.60, 1.00));
    defineConstant("B", c(0.00, 0.00, 0.00, 0.00, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.00, 1.10, 1.20));
    defineConstant("W", c(25000.00, 25000.00, 13500.00, 8370.00, 5524.00, 3811.70, 2706.31, 1867.35, 1232.45, 764.12, 427.91, 192.56, 86.65, 38.99, 17.55, 7.02)); // on définit les proportions relatives W des différentes classes d'âge (les valeurs brutes importent peu, seules leurs proportions relatives sont importantes: elles définissent la structure en âge de chaque sous-population).
    defineConstant("m", 0.05); // taux de migration m, qui sera constant et symétrique entre sous-populations.

    // initialisation des fichiers de sortie pour le stockage des informations démographiques des individus simulés:
    // ces fichiers sont analogues aux fichiers générés par le logiciel Spip utilisé par la librairie R CKMRpop.
    writeFile("SLiM_prekill_census.tsv", "year\tpop\tage\tmale\tfemale");
    writeFile("SLiM_postkill_census.tsv", "year\tpop\tage\tmale\tfemale");
    writeFile("SLiM_demo_table.tsv", "generation\tgen_time\tkbar\tvk\tne_demo");
    writeFile("SLiM_samples.tsv", "ID\tsyears_pre\tpop_pre\tsyears_post\tpop_post\tsyears_dur\tpop_dur");
    writeFile("SLiM_ancestries.tsv", "ID\tancestors");  

    // initialisation d'un objet de type dictionnaire, vide pour le moment, qui servira à stocker des informations nécessaires au calcul du temps de génération et de la variance de succès reproducteur ("variance in lifetime reproductive output") entre individus, que nous effectuerons sur plusieurs cohortes successives. Ces informations permettront d'obtenir la taille efficace démographique, par génération, des deux sous-populations simulées.
    defineGlobal("n_offspring", Dictionary());
}</code></pre>
<p>Après cette phase d'initialisation, il va nous falloir définir les modalités des événements de reproduction (qui assurent par ailleurs le passage d'un pas de temps au suivant). Ceci s'effectue dans une section ("callback") <em>reproduction()</em>. Un géniteur et une génitrice sont échantillonnés avec une probabilité qui dépend de leur âge et du paramètre vecteur <strong><em>B</em></strong>. Le couple génère un nombre non-nul de descendants suivant une loi de Poisson de paramètre 2,3. Le processus de tirage géniteur-génitrice se poursuit jusqu'à que le nombre de 5000 nouveaux-nés soit atteint. A ce stade, l'effectif stable des sous-populations n'est donc pas une propriété émergente du modèle. Bien qu'il serait plus élégant qu'il le soit, cela n'impacte cependant pas la validité des informations démographiques et génomiques générées.</p>
<p>Dans ce même "callback" <em>reproduction()</em>, le dictionnaire "n_offspring" stocke peu à peu des informations sur le nombre total de descendants générés, au cours de leur existance, par 11 cohortes successives. Une fonction permet d'en déduire la taille efficace démographique par génération ainsi que le temps de génération moyen. Ces informations sont exportées au fur et à mesure dans le fichier <code>SLiM_demo_table.tsv</code>.</p>
<p>Script <code>POPSIZE_SLiM_Cohort5000_m005.txt</code> <strong>(Partie 2/4)</strong></p>

<pre><code>reproduction() { 

    for (subpop0 in sim.subpopulations) {
        fecundity = B[subpop0.individuals.age];
        subpop0.individuals.tagF = fecundity;
        potential_dads = subpop0.individuals[subpop0.individuals.age &gt; 0 &amp; subpop0.individuals.sex == "M"];
        potential_moms = subpop0.individuals[subpop0.individuals.age &gt; 0 &amp; subpop0.individuals.sex == "F"];
        current_cohort_size = c(0);
        final_cohort_size = 5000; // nombre final de nouveaux-nés souhaité en fin de reproduction.

        while (current_cohort_size &lt; final_cohort_size) {
            dad = sample(potential_dads, size = 1, replace = F, weights = potential_dads.tagF);
            mom = sample(potential_moms, size = 1, replace = F, weights = potential_moms.tagF);
            litterSize = 0;
            do { 
                litterSize = rpois(1, 2.3);
            }
            while (litterSize == 0);

            if (sim.generation &lt; 28) {
                vec_mom = n_offspring.getValue(format('%d', mom.pedigreeID));
                vec_mom[1] = asFloat(((vec_mom[0] * vec_mom[1]) + (asFloat(litterSize) * asFloat(mom.age))) / (vec_mom[0] + asFloat(litterSize)));
                vec_mom[0] = asFloat(vec_mom[0] + asFloat(litterSize));
                n_offspring.setValue(format('%d', mom.pedigreeID), vec_mom);
                vec_dad = n_offspring.getValue(format('%d', dad.pedigreeID));
                vec_dad[1] = asFloat(((vec_dad[0] * vec_dad[1]) + (asFloat(litterSize) * asFloat(dad.age))) / (vec_dad[0] + asFloat(litterSize)));
                vec_dad[0] = asFloat(vec_dad[0] + asFloat(litterSize));
                n_offspring.setValue(format('%d', dad.pedigreeID), vec_dad);
            }

            for (j in seqLen(litterSize)) {
                offspring = subpop0.addCrossed(mom, dad);
                offspring.tag = subpop0.id;
                if (sim.generation &lt; 28) {                
                    n_offspring.setValue(format('%d', offspring.pedigreeID), c(0.0, 0.0, asFloat(sim.generation)));         
                }
            }
            current_cohort_size = current_cohort_size + litterSize;
        }               
    }       

    // Calcul de la taille efficace démographique et du temps de génération pour la cohorte née 15 ans plus tôt (toutes sous-populations confondues):
    if (sim.generation &gt; 16 &amp; sim.generation &lt; 28) { // ce calcul est effectué sur 11 cohortes successives, nées du pas de temps 2 au pas de temps 12, et uniquement lorsque l'ensemble des individus d'une même cohorte sont décédés et ne peuvent assurément plus se reproduire (c'est-à-dire 15 pas de temps après leur naissance).
        test0 = c(0.0, 0.0, 0.0);
        for (i in unique(n_offspring.allKeys)) {
            if (n_offspring.getValue(i)[2] == asFloat(sim.generation - 15)) {
                test0 = rbind(test0, n_offspring.getValue(i));
                n_offspring.setValue(i, NULL);
            }
        }
        lifetime_kbar = mean(test0[1:nrow(test0)-1, 0]);
        lifetime_vk = var(c(test0[1:nrow(test0)-1, 0]));
        gen_time = sum(test0[, 0]*test0[, 1])/sum(test0[, 0]); // temps de génération
        ne_demo = (4*nrow(test0)*gen_time)/(lifetime_vk+2); // taille efficace démographique
        line = paste(c(sim.generation - 15, gen_time, lifetime_kbar, lifetime_vk, ne_demo), sep = "\t");
        writeFile("SLiM_demo_table.tsv", line, append=T);            
    }

    if (sim.generation == 28) { // désactivation du dictionnaire 'n_offspring' au-delà du pas de temps 28.
        // Ceci permet d'accélérer la vitesse de simulation à partir de maintenant.
        rm(variableNames="n_offspring");    
    }

    self.active = 0; // le callback reproduction() se désactive de lui-même lorsque le nombre de nouveaux-nés atteint 5000.
}</code></pre>
<p>Dans la section ("callback") <em>early()</em> du pas de temps 1, on initialise directement les deux sous-populations à l'abondance totale <strong><em>K</em></strong> en "remplissant" chacune des classes d'âges en fonction de la structure en âges fixée par le paramètre vecteur <strong><em>W</em></strong>. D'une manière générale, les sections <em>early()</em> permettent ici de faire intervenir la migration symétrique entre sous-populations et l'enregistrement des effectifs précis par classe d'âge avant survenue de la mortalité.</p>
<p>Script <code>POPSIZE_SLiM_Cohort5000_m005.txt</code> <strong>(Partie 3/4)</strong></p>

<pre><code>1 early() { // pour le premier pas de temps (début de la simulation).

    sim.addSubpop("p1", K);
    sim.addSubpop("p2", K);
    p1.individuals.age = sample(seq(0, 15), size = K, replace = T, weights = W); // remplissage de la sous-population p1.
    p2.individuals.age = sample(seq(0, 15), size = K, replace = T, weights = W); // remplissage de la sous-population p2.
    p1.individuals.tag = 1;
    p2.individuals.tag = 2;

    for (i in c(p1.individuals.pedigreeID, p2.individuals.pedigreeID)) {
        n_offspring.setValue(format('%d', i), c(0.0,0.0,1.0));
    }
}

early() { // pour chaque pas de temps, avant survenue de la mortalité.

    // enclenche le processus de migration entre sous-populations :
    nIndividuals = sum(sim.subpopulations.individualCount);
    nMigrants = rpois(1, nIndividuals * m);
    migrants = sample(sim.subpopulations.individuals, nMigrants);

    for (migrant in migrants) {
        do dest = sample(sim.subpopulations, 1);
        while (dest == migrant.subpopulation);
        dest.takeMigrants(migrant);
    }    

    // enregistre l'effectif de chaque classe d'âge, avant mortalité, dans le fichier de sortie "SLiM_prekill_census.tsv":
    for (subpop in sim.subpopulations) {    
        print(tabulate(subpop.individuals.age, maxbin=15));
        inds = subpop.individuals;
        ages = inds.age;
        age_bins = 0:15;  // age categories, 0 to 15
        male_ages = ages[inds.sex == "M"];
        female_ages = ages[inds.sex == "F"];
        m_census = tabulate(male_ages, maxbin = 15);
        f_census = tabulate(female_ages, maxbin = 15);      

        for(a in age_bins) {
            line = paste(sim.generation, subpop.id, a, m_census[a], f_census[a], sep = "\t");
            writeFile("SLiM_prekill_census.tsv", line, append=T); // effectifs par classe d'âge avant mortalité.
        }        

        mortality = L[ages];
        survival = 1 - mortality;
        inds.fitnessScaling = survival;
    }
}</code></pre>
<p>D'une manière générale, les sections <em>late()</em> permettent ici l'enregistrement des effectifs précis par classe d'âge après survenue de la mortalité.</p>
<p>Plus important, elles nous permettent également ici d'effectuer un "échantillonnage" en série (c'est-à-dire sur plusieurs pas de temps successifs) d'individus, plus précisément au cours des 11 derniers pas de temps (90 à 100) de la simulation. Il s'agit de stocker l'information génétique et démographique d'une partie des individus au sein des sous-populations simulées. Ici, on "échantillonne" une proportion de 10% de chaque classe d'âge de 1 à 15 ans (<code>ns = rbinom(1, num_1_to_15, 0.10);</code>) (ce qui, notons-le, serait beaucoup plus laborieux pour des effectifs de populations plus élevés que 17710, pour lesquels il faudrait alors sans doute diminuer cette proportion). Il faut également noter que cet échantillonnage se fait avec remise: un individu échantillonné ne disparaît pas de la population, et peut potentiellement être ré-échantillonné lors d'un pas de temps suivant du simple fait du hasard, comme dans le cas d'un protocole de capture-marquage recapture. Il est possible, si nécessaire, de tenir compte de cet état de fait au cours du post-traitement des données simulées puisque chaque individu possède un identifiant unique, que l'on conserve lors de l'export des informations démographiques.</p>
<p>Chaque individu échantillonné verra ses informations démographiques (e.g., pas de temps de naissance, âge(s)/lieu(x)/pas de temps de capture) sauvegardées au sein du fichier <code>SLiM_samples.tsv</code>. Grâce à l'activation de l'enregistrement du pedigree, nous pouvons également sauvegarder les identifiants uniques des parents et des grands-parents de chaque individu échantillonné, au sein du fichier <code>SLiM_ancestries.tsv</code>. Par ailleurs, les généalogies de gènes correspondant aux individus échantillonnés sont conservées grâce à l'activation de la fonction <code>sim.treeSeqRememberIndividuals();</code>. C'est ce qui permettra d'attribuer à ces individus une information génétique lors de la prochaine phase de simulation basée sur le coalescent. Sans cette option, seuls les individus présents au tout dernier pas de temps simulé sont assurés d'être exportés avec une généalogie de gènes correcte. Dans le cadre d'un échantillonnage en série (<em>serial sampling</em>) comme effectué ici, la fonction <code>sim.treeSeqRememberIndividuals();</code> est donc très importante.</p>
<p>Script <code>POPSIZE_SLiM_Cohort5000_m005.txt</code> <strong>(Partie 4/4)</strong></p>

<pre><code>late() {
    // enregistre l'effectif de chaque classe d'âge, après mortalité, dans le fichier de sortie "SLiM_postkill_census.tsv":
    for (subpop in sim.subpopulations) {
        inds = subpop.individuals;
        ages = inds.age;
        age_bins = 0:15;  // age categories, 0 to 15
        male_ages = ages[inds.sex == "M"];
        female_ages = ages[inds.sex == "F"];
        m_census = tabulate(male_ages, maxbin = 15);
        f_census = tabulate(female_ages, maxbin = 15);

        for(a in age_bins) {
            line = paste(sim.generation, subpop.id, a, m_census[a], f_census[a], sep = "\t");
            writeFile("SLiM_postkill_census.tsv", line, append=T);  // effectifs par classe d'âge après mortalité.
        }
    }
}

90:100 late() {
    for (subpop in sim.subpopulations) {
        num_1_to_15 = sum(tabulate(subpop.individuals.age, maxbin = 15)[1:15]);

        ns = rbinom(1, num_1_to_15, 0.10); // on collecte l'information démographique et généalogique d'une partie des individus simulés ("échantillonnage"). 
        samps = subpop.sampleIndividuals(ns, minAge = 1, maxAge = 15);
        sim.treeSeqRememberIndividuals(samps); // SLiM va conserver l'information généalogique des individus échantillonnés.

        for(s in samps) {
            s_name = paste0(s.sex, sim.generation - s.age, "_", s.tag, "_", s.pedigreeID);
            line = paste(s_name, "", "", sim.generation, subpop.id, "", "", sep = "\t");
            writeFile("SLiM_samples.tsv", line, append = T);        
            s_anc = c(s.pedigreeID, s.pedigreeParentIDs, s.pedigreeGrandparentIDs);
            s_anc = s_anc[c(0, 2, 1, 6, 5, 4, 3)];
            s_anc_commas = paste(s_anc, sep = ",");
            line = paste(s_name, s_anc_commas, sep = "\t");
            writeFile("SLiM_ancestries.tsv", line, append = T); // exporte les informations de pedigree des individus échantillonnés (parents et grands-parents).
        }
    }
}

100 late() { // enfin, lors du tout dernier pas de temps simulé, on exporte le "tree sequence" contenant la généalogie des gènes de tous les individus du temps présent, mais aussi ceux dont l'information a été conservée par la fonction 'sim.treeSeqRememberIndividuals();'.
    sim.treeSeqOutput("POPSIZE_SLiM_Cohort5000_m005.trees");
}

// Fin du script Eidos.</code></pre>
<p>Le fichier final <code>POPSIZE_SLiM_Cohort5000_m005.trees</code> est notre principale sortie pour le moment. Avec le fichier <code>SLiM_demo_table.tsv</code>, il va nous permettre de passer à l'étape n°2, à savoir la reconstitution de la trajectoire évolutive passée (c'est-à-dire antérieure aux 100 pas de temps simulés à l'aide du logiciel SLiM) de nos deux sous-populations. Cette reconstitution s'effectue sur la base de la topologie du <strong>tree sequence</strong> exporté via SLiM et à l'aide d'une approche par coalescence implémentée dans les librairies Python <em>pyslim</em> et <em>msprime</em>, un procédé appelé <strong>récapitation</strong>. Nous allons donc à présent quitter le langage de programmation Eidos et utiliser la console Python.</p>

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<h2 id="Etape-n&#176;2.">Etape n&#176;2.<a class="anchor-link" href="#Etape-n&#176;2.">&#182;</a></h2><h2 id="Simulation-de-la-trajectoire-&#233;volutive-pass&#233;e-des-sous-populations-&#224;-l'aide-d'une-approche-par-coalescence-:">Simulation de la trajectoire &#233;volutive pass&#233;e des sous-populations &#224; l'aide d'une approche par coalescence :<a class="anchor-link" href="#Simulation-de-la-trajectoire-&#233;volutive-pass&#233;e-des-sous-populations-&#224;-l'aide-d'une-approche-par-coalescence-:">&#182;</a></h2><h3 id="pyslim-ver.-0.700-et-msprime-ver.-1.2.0">pyslim ver. 0.700 et msprime ver. 1.2.0<a class="anchor-link" href="#pyslim-ver.-0.700-et-msprime-ver.-1.2.0">&#182;</a></h3><p>Nous exécutons à présent le script Python dans notre console Anaconda à l'aide de la commande <code>python POPSIZE_pyslim_Cohort5000_m005.py &gt; output_POPSIZE_pyslim_Cohort5000_m005.txt</code>.</p>
<p>Le script <code>POPSIZE_pyslim_Cohort5000_m005.py</code> s'écrit comme suit. Nous allons là encore découper ce fichier en plusieurs parties afin d'en faciliter la lecture et la compréhension.</p>
<p>Script <code>POPSIZE_pyslim_Cohort5000_m005.py</code> <strong>(Partie 1/7)</strong></p>
<p>Il s'agit dans un premier d'importer l'ensemble des outils nécessaires dans notre environnement de travail. 
Puis, nous importons notre principal fichier de travail: le fichier <strong>tree sequence</strong> issu de l'étape n°1. La fonction <code>print(ts)</code> nous permet de visualiser quelques informations sur ce <strong>tree sequence</strong>. On retrouve environ 2.6e06 généalogies distinctes ('trees') ainsi que la taille de 2.0 Gb du génome simulé. Le <strong>tree sequence</strong> contient 36 521 individus, comprenant la totalité des individus survivants du tout dernier pas de temps simulé dans SLiM, mais également des individus échantillonnés auparavant et décédés mais dont l'information a été conservée par la fonction 'sim.treeSeqRememberIndividuals();'.</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Importation des librairies Python nécessaires:</span>
<span class="kn">import</span> <span class="nn">datetime</span><span class="o">,</span> <span class="nn">demesdraw</span><span class="o">,</span> <span class="nn">functools</span><span class="o">,</span> <span class="nn">itertools</span><span class="o">,</span> <span class="nn">math</span><span class="o">,</span> <span class="nn">msprime</span><span class="o">,</span> <span class="nn">os</span><span class="o">,</span> <span class="nn">pyslim</span><span class="o">,</span> <span class="nn">tskit</span>  
<span class="kn">import</span> <span class="nn">matplotlib.pyplot</span> <span class="k">as</span> <span class="nn">plt</span>
<span class="kn">import</span> <span class="nn">numpy</span> <span class="k">as</span> <span class="nn">np</span>
<span class="kn">import</span> <span class="nn">pandas</span> <span class="k">as</span> <span class="nn">pd</span>
<span class="kn">import</span> <span class="nn">statistics</span> <span class="k">as</span> <span class="nn">s</span>

<span class="c1"># Paramètres de la simulation en cours: </span>
<span class="n">str1</span> <span class="o">=</span> <span class="s2">&quot;5000&quot;</span>
<span class="n">str2</span> <span class="o">=</span> <span class="s2">&quot;m005&quot;</span>
<span class="n">migrate</span> <span class="o">=</span> <span class="mf">0.05</span>

<span class="nb">print</span><span class="p">(</span><span class="s1">&#39;Hi! You are currently using pyslim ver &#39;</span><span class="p">,</span> <span class="n">pyslim</span><span class="o">.</span><span class="n">__version__</span><span class="p">,</span> <span class="s1">&#39;, tskit ver &#39;</span><span class="p">,</span> <span class="n">tskit</span><span class="o">.</span><span class="n">__version__</span><span class="p">,</span> <span class="s1">&#39; and msprime ver &#39;</span><span class="p">,</span> <span class="n">msprime</span><span class="o">.</span><span class="n">__version__</span><span class="p">,</span> <span class="s1">&#39;. See you soon.&#39;</span><span class="p">,</span> <span class="n">sep</span><span class="o">=</span><span class="s1">&#39;&#39;</span><span class="p">)</span>
<span class="n">current_day</span> <span class="o">=</span> <span class="n">datetime</span><span class="o">.</span><span class="n">datetime</span><span class="o">.</span><span class="n">now</span><span class="p">()</span><span class="o">.</span><span class="n">strftime</span><span class="p">(</span><span class="s2">&quot;%Y%m</span><span class="si">%d</span><span class="s2">&quot;</span><span class="p">)</span>

<span class="c1"># Importation du fichier &quot;tree sequence&quot; issu de l&#39;étape n°1:</span>
<span class="c1"># os.getcwd()</span>
<span class="c1"># os.chdir(&#39;C:\\Users\\Sidon\\OneDrive\\Documents\\SLiM_5000_m005_runfiles&#39;)</span>
<span class="n">ts</span> <span class="o">=</span> <span class="n">pyslim</span><span class="o">.</span><span class="n">load</span><span class="p">(</span><span class="s2">&quot;POPSIZE_SLiM_Cohort</span><span class="si">%s</span><span class="s2">_</span><span class="si">%s</span><span class="s2">.trees&quot;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">))</span>
<span class="nb">print</span><span class="p">(</span><span class="n">ts</span><span class="p">)</span>
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<pre>Hi! You are currently using pyslim ver 0.700, tskit ver 0.4.1 and msprime ver 1.2.0. See you soon.
╔══════════════════════════╗
║TreeSequence              ║
╠═══════════════╤══════════╣
║Trees          │   2562579║
╟───────────────┼──────────╢
║Sequence Length│2000000000║
╟───────────────┼──────────╢
║Time Units     │     ticks║
╟───────────────┼──────────╢
║Sample Nodes   │     73042║
╟───────────────┼──────────╢
║Total Size     │ 209.4 MiB║
╚═══════════════╧══════════╝
╔═══════════╤═══════╤═════════╤════════════╗
║Table      │Rows   │Size     │Has Metadata║
╠═══════════╪═══════╪═════════╪════════════╣
║Edges      │5248573│160.2 MiB│          No║
╟───────────┼───────┼─────────┼────────────╢
║Individuals│  36521│  3.5 MiB│         Yes║
╟───────────┼───────┼─────────┼────────────╢
║Migrations │      0│  8 Bytes│          No║
╟───────────┼───────┼─────────┼────────────╢
║Mutations  │      0│  1.2 KiB│          No║
╟───────────┼───────┼─────────┼────────────╢
║Nodes      │ 157113│  5.7 MiB│         Yes║
╟───────────┼───────┼─────────┼────────────╢
║Populations│      3│  2.3 KiB│         Yes║
╟───────────┼───────┼─────────┼────────────╢
║Provenances│      1│ 12.3 KiB│          No║
╟───────────┼───────┼─────────┼────────────╢
║Sites      │      0│ 16 Bytes│          No║
╚═══════════╧═══════╧═════════╧════════════╝

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<p>Script <code>POPSIZE_pyslim_Cohort5000_m005.py</code> <strong>(Partie 2/7)</strong></p>
<p>On importe le fichier <code>SLiM_demo_table.tsv</code> qui nous permettra d'extraire la taille efficace démographique calculée par génération au cours de l'étape n°1 pour chacune des sous-populations. On vérifie que le nombre d'individus toujours en vie lors du dernier pas de temps simulé dans SLiM (s'élevant à 25435 d'après le fichier <code>SLiM_postkill_census.tsv</code> pour le pas de temps 100) se retrouve bien dans notre <strong>tree sequence</strong> au pas de temps 0 (<code>ts.individuals_alive_at(0)</code>), qui nous rapporte effectivement un total de 12692+12743 = 25435 individus.</p>
<p>Enfin, nous visualisons la distribution des temps de coalescence le long du génome simulé. En seulement 100 pas de temps simulé avec SLiM, il est très peu probable que le TMRCA ("<em>time to the most recent common antestor</em>", la racine de la généaloge de gènes) ait pu être atteint où que ce soit le long du génome, et nous nous attendons à ce que la taille des généalogies, en nombre de pas de temps, soit homogène et corresponde simplement au nombre de pas de temps simulés.</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Importation du fichier &quot;SLiM_demo_table.tsv&quot; issu de l&#39;étape n°1:</span>
<span class="n">SLiM_demo</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">read_table</span><span class="p">(</span><span class="s2">&quot;SLiM_demo_table.tsv&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span><span class="s1">&#39;</span><span class="se">\t</span><span class="s1">&#39;</span><span class="p">,</span> <span class="n">header</span> <span class="o">=</span> <span class="mi">0</span><span class="p">,</span> <span class="n">index_col</span><span class="o">=</span><span class="kc">False</span><span class="p">)</span>

<span class="c1"># Visualisation des populations au temps présent (0 générations en arrière, correspond au dernier pas de temps simulé dans SLiM):</span>
<span class="n">alive</span> <span class="o">=</span> <span class="n">ts</span><span class="o">.</span><span class="n">individuals_alive_at</span><span class="p">(</span><span class="mi">0</span><span class="p">)</span>
<span class="n">num_alive</span> <span class="o">=</span> <span class="p">[</span><span class="mi">0</span> <span class="k">for</span> <span class="n">_</span> <span class="ow">in</span> <span class="nb">range</span><span class="p">(</span><span class="n">ts</span><span class="o">.</span><span class="n">num_populations</span><span class="p">)]</span>
<span class="k">for</span> <span class="n">i</span> <span class="ow">in</span> <span class="n">alive</span><span class="p">:</span>
  <span class="n">ind</span> <span class="o">=</span> <span class="n">ts</span><span class="o">.</span><span class="n">individual</span><span class="p">(</span><span class="n">i</span><span class="p">)</span>
  <span class="n">num_alive</span><span class="p">[</span><span class="n">ind</span><span class="o">.</span><span class="n">population</span><span class="p">]</span> <span class="o">+=</span> <span class="mi">1</span>

<span class="k">for</span> <span class="n">pop</span><span class="p">,</span> <span class="n">num</span> <span class="ow">in</span> <span class="nb">enumerate</span><span class="p">(</span><span class="n">num_alive</span><span class="p">):</span>
  <span class="nb">print</span><span class="p">(</span><span class="n">f</span><span class="s2">&quot;Nombre d&#39;individus au temps présent dans la population </span><span class="si">{pop}</span><span class="s2">: </span><span class="si">{num}</span><span class="s2">&quot;</span><span class="p">)</span> <span class="c1"># Nombre d&#39;individus vivants au dernier pas de temps avant reproduction.</span>

<span class="c1"># Calcul de la taille (en générations) des généalogies/arbres de coalescence (= &quot;tree heights&quot;):</span>
<span class="k">def</span> <span class="nf">tree_heights</span><span class="p">(</span><span class="n">ts</span><span class="p">):</span>
    <span class="n">heights</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">zeros</span><span class="p">(</span><span class="n">ts</span><span class="o">.</span><span class="n">num_trees</span> <span class="o">+</span> <span class="mi">1</span><span class="p">)</span>
    <span class="k">for</span> <span class="n">tree</span> <span class="ow">in</span> <span class="n">ts</span><span class="o">.</span><span class="n">trees</span><span class="p">():</span>
        <span class="k">if</span> <span class="n">tree</span><span class="o">.</span><span class="n">num_roots</span> <span class="o">&gt;</span> <span class="mi">1</span><span class="p">:</span> <span class="c1"># MRCA non atteint</span>
            <span class="n">heights</span><span class="p">[</span><span class="n">tree</span><span class="o">.</span><span class="n">index</span><span class="p">]</span> <span class="o">=</span> <span class="n">ts</span><span class="o">.</span><span class="n">slim_generation</span>
        <span class="k">else</span><span class="p">:</span>
            <span class="n">children</span> <span class="o">=</span> <span class="n">tree</span><span class="o">.</span><span class="n">children</span><span class="p">(</span><span class="n">tree</span><span class="o">.</span><span class="n">root</span><span class="p">)</span>
            <span class="n">real_root</span> <span class="o">=</span> <span class="n">tree</span><span class="o">.</span><span class="n">root</span> <span class="k">if</span> <span class="nb">len</span><span class="p">(</span><span class="n">children</span><span class="p">)</span> <span class="o">&gt;</span> <span class="mi">1</span> <span class="k">else</span> <span class="n">children</span><span class="p">[</span><span class="mi">0</span><span class="p">]</span>
            <span class="n">heights</span><span class="p">[</span><span class="n">tree</span><span class="o">.</span><span class="n">index</span><span class="p">]</span> <span class="o">=</span> <span class="n">tree</span><span class="o">.</span><span class="n">time</span><span class="p">(</span><span class="n">real_root</span><span class="p">)</span>
    <span class="n">heights</span><span class="p">[</span><span class="o">-</span><span class="mi">1</span><span class="p">]</span> <span class="o">=</span> <span class="n">heights</span><span class="p">[</span><span class="o">-</span><span class="mi">2</span><span class="p">]</span>
    <span class="k">return</span> <span class="n">heights</span>

<span class="c1"># Visualisation de la taille (en générations) des arbres de coalescences avant récapitation (elle devrait être identique pour tous les loci: y=nombre de pas de temps simulés avec SLiM):</span>
<span class="n">breakpoints</span> <span class="o">=</span> <span class="nb">list</span><span class="p">(</span><span class="n">ts</span><span class="o">.</span><span class="n">breakpoints</span><span class="p">())</span>
<span class="n">heights</span> <span class="o">=</span> <span class="n">tree_heights</span><span class="p">(</span><span class="n">ts</span><span class="p">)</span>
<span class="n">plt</span><span class="o">.</span><span class="n">step</span><span class="p">(</span><span class="n">breakpoints</span><span class="p">,</span> <span class="n">heights</span><span class="p">,</span> <span class="n">where</span><span class="o">=</span><span class="s1">&#39;post&#39;</span><span class="p">)</span>
<span class="n">plt</span><span class="o">.</span><span class="n">show</span><span class="p">()</span>
<span class="n">plt</span><span class="o">.</span><span class="n">savefig</span><span class="p">(</span><span class="s1">&#39;pyslim_tree_height0_Cohort</span><span class="si">%s</span><span class="s1">_</span><span class="si">%s</span><span class="s1">.png&#39;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">))</span>
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<pre>Nombre d&#39;individus au temps présent dans la population 0: 0
Nombre d&#39;individus au temps présent dans la population 1: 12692
Nombre d&#39;individus au temps présent dans la population 2: 12743
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<pre>/home2/datawork/cdelord/conda-env/simupop-slim/lib/python3.7/site-packages/pyslim/slim_tree_sequence.py:36: FutureWarning: The SlimTreeSequence class is being phased out, as most important functionality is provided by tskit. Please see the `documentation &lt;https://tskit.dev/pyslim/latest/previous_versions.html&gt;`_. Please access ts.metadata[&#39;SLiM&#39;][&#39;generation&#39;] instead.
  FutureWarning
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<pre>&lt;Figure size 432x288 with 0 Axes&gt;</pre>
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<p>Script <code>POPSIZE_pyslim_Cohort5000_m005.py</code> <strong>(Partie 3/7)</strong></p>
<p>La phase de récapitation va permettre de compléter les généalogies de gènes présentes dans notre <strong>tree sequence</strong>, c'est-à-dire à faire en sorte que le TMRCA soit atteint sur l'ensemble du génome simulé. Pour cela, il nous faut fournir à <em>pyslim</em> des informations sur la démographie présente et passée des sous-populations simulées. C'est ce que nous ferons à l'aide du module <code>msprime.Demography.from_tree_sequence(ts)</code>.</p>
<p>Afin de garder une taille efficace constante tout au long de la chronologie (ce qui n'est pas obligatoire et ne sera pas toujours le cas, mais s'avère plus simple pour le présent exemple), nous allons choisir comme point de départ, au temps présent, la taille efficace démographique que nous avons calculée sur plusieurs cohortes successives au cours de l'étape n°1. La trajectoire évolutive simulée ici pour le passé de nos deux sous-populations sera très simple: on considèrera que les deux sous-populations ont toujours conservé une taille efficace constante depuis leur divergence. Elles constituaient auparavant une seule et même population ancestrale, dont la taille efficace correspondait à la somme de leurs tailles efficaces locales. Tout ceci peut être visualisé à l'aide des représentations obtenues via le module <code>demography.debug()</code>.</p>
<p>Un simple calcul de moyenne harmonique depuis <code>SLiM_demo_table.tsv</code> indique que la taille efficace démographique s'élève à 2772 par génération et par sous-population, en moyenne, pour cette simulation SLiM. Le temps de génération est estimé, quant à lui, à 6,989.</p>
<p>Avant d'aller plus loin, il nous faut évoquer un point <strong>crucial</strong> concernant la combinaison de simulations de type <strong>nonWF</strong> avec SLiM, et de type Wright-Fisher (coalescent) avec <em>pyslim</em>/<em>msprime</em>. Ce point de précaution indispensable est souligné par l'avertissement qui s'affiche en rouge en sortie de cette portion de code. En effet, l'unité de temps considérée par SLiM et <em>pyslim</em>/<em>msprime</em> n'est pas la même: elle correspond à un pas de temps/cycle de reproduction/"tick" dans le premier cas, et à une génération de Wright-Fisher dans le second cas. Il nous faut donc procéder à un ré-échelonnage de certains paramètres (a minima la taille efficace, les taux de mutation et de recombinaison) afin d'en tenir compte et d'assurer un bon ajustement des simulations individu-centrées avec celles basées sur le coalescent. Une discussion détaillée de cela est disponible dans la section <a href="https://tskit.dev/pyslim/docs/latest/time_units.html">Time Units</a> du manuel en ligne <em>pyslim</em>. D'autres informations utiles sont consultables par cet échange direct avec les développeurs de la librarie : <a href="https://groups.google.com/g/slim-discuss/c/QAmTUZROzSE">Seeking for best practices with hybrid "backward-forward" simulation</a>.</p>
<p>Nous pouvons désormais poursuivre:</p>
<ul>
<li><strong>Précisions sur la taille efficace <em>Ne</em> à définir dans <code>pop.initial_size</code>:</strong></li>
</ul>
<p>Comme mentionné plus tôt, la valeur de 2772 correspond à la taille efficace démographique, par génération et par sous-population, calculée à partir des données simulées dans SLiM. Elle tient compte du temps de génération et est différente de la taille efficace calculée par cycle de reproduction, qui correspondrait à une valeur <em>Nb</em> (effective number of breeders). Dans la mesure où les deux populations simulées présentent une taille efficace égale et constante dans le temps, et dans la mesure où ces deux sous-populations échangent des flux de gènes constants et symétriques, nous devrions pouvoir considérer que la taille efficace globale correspond à la somme des tailles efficaces locales (e.g, <a href="https://www.nature.com/articles/6884670/">Wang &amp; Caballero, 1999</a>). C'est pourquoi ici, nous obtenons <code>Ne_demo</code> en divisant la valeur de taille efficace globale issue <code>SLiM_demo_table.tsv</code> par 2. Afin de ré-échelonner la taille efficace pour tenir compte de la différence d'unité de temps entre SLiM et <em>pyslim</em>/<em>msprime</em>, il nous faut multiplier <code>Ne_demo</code> par le temps de génération <code>gen_time</code>. Nous obtenons ainsi la valeur <code>Ne_pyslim</code> à renseigner dans <code>pop.initial_size</code>.</p>
<p>En outre, notre taille efficace démographique <code>Ne_demo</code> (qui est un type de taille efficace de variance) est donc ici utilisée comme un proxy de taille efficace de valeur propre (qui est une valeur asymptotique de taille efficace vers laquelle tailles efficace de variance et de consanguinité convergent à l'équilibre à l'échelle d'un groupe de populations). A moins que des événements démographiques critiques n'interviennent au cours de la trajectoire évolutive des sous-populations, nous devrions pouvoir  considérer que cette taille efficace démographique / de valeur propre soit également équivalente à la taille efficace de coalescence (<a href="https://onlinelibrary.wiley.com/doi/10.1111/mec.15027">Ryman et al. 2019</a>) et donc utilisable dans le modèle démographique utilisé ici dans <em>pyslim</em> une fois ré-échelonnée (e.g, <code>Ne_pyslim</code>). Cette approximation est permise par la très grande simplicité de la trajectoire évolutive simulée ici.</p>
<p>Cependant, si l'on souhaitait simuler des événements démographiques contemporains (e.g., bottleneck ou déclin d'abondance lié à la surpêche), ou passés (e.g., croissance de la population ancestrale au cours du Pléistocène) ou encore, si l'on souhaitait modéliser des dynamiques distinctes entre les deux sous-populations (e.g., déclin de l'abondance d'une des sous-populations tandis que la seconde garde un effectif stable), alors nous devrions reconsidérer tout cela. La taille efficace démographique devrait vraisemblablement être calculée d'une autre manière lors de l'étape n°1 de SLiM (cf., rapport scientifique final du projet POPSIZE section I.b). Cette taille efficace ne serait plus nécessairement équivalente à la taille efficace de coalescence, et une réflexion serait à mener pour établir la meilleure manière de modéliser la trajectoire évolutive passée des sous-populations dans le module <code>msprime.Demography.from_tree_sequence(ts)</code> de <em>pyslim</em> en intégrant à la fois cette taille efficace contemporaine, ses fluctuations en remontant le temps, et sa transition éventuelle vers la taille efficace de coalescence.</p>
<p>Voir aussi: <a href="https://groups.google.com/g/slim-discuss/c/qJga1wTPliE">Questions about treeseq good practices</a></p>
<ul>
<li><strong>Précisions sur le flux de migration <em>migrate</em> à définir dans <code>demography.set_symmetric_migration_rate</code>:</strong></li>
</ul>
<p>Dans notre cas, pour lequel les flux de migration sont symétriques entre deux sous-populations de taille efficace et d'abondance identiques, nous pouvons garder la même valeur du paramètre de migration <em>m</em> et <em>migrate</em> entre l'étape n°1 SLiM et l'étape n°2 <em>pyslim</em>. Cela, bien que la définition du paramètre de migration ne soit pas strictement identique entre les deux logiciels (pour SLiM, il s'agit de la proportion moyenne d'individus d'une sous-population qui migrent vers une autre, alors que pour <em>pyslim</em>/<em>msprime</em>, il s'agit de la proportion d'individus haploides d'une sous-population ayant un parent issu d'une autre sous-population). Là encore, si l'on souhaitait simuler des sous-populations d'effectifs différents et/ou avec des flux de migration asymétriques, nous devrions fixer les flux de migration de manière différente entre les étapes respectives SLiM et <em>pyslim</em>.</p>
<p>Voir aussi: <a href="https://github.com/tskit-dev/msprime/issues/2003">Coalescence trajectory for non symmetric migration</a>
Voir aussi: <a href="https://tskit.dev/msprime/docs/stable/demography.html#definitions">msprime doc &gt; Demographic Models &gt; Model &gt; Definitions</a></p>
<ul>
<li><strong>Précisions sur les taux de recombinaison à définir dans <code>pyslim.recapitate()</code>:</strong></li>
</ul>
<p>Tout comme la taille efficace et le taux de mutation (cf., Partie 6/7), les taux de recombinaison doivent être ré-échelonnés pour tenir compte de la différence d'unité de temps considérée par SLiM et <em>pyslim</em>. On obtient le taux de recombinaison par génération de Wright-Fisher en divisant le taux de recombinaison fixé dans SLiM (exprimé par pas de temps/cycle de reproduction/méiose), par le temps de génération. Ici, on considère donc: <code>r_chrom</code> = 1e-08 / 6.98 = 1.435e-9. Le même calcul s'appliquera au taux de mutation (cf., Partie 6/7).</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># -------------------------------------------------------------------------------------------</span>
<span class="c1"># RECAPITATION (ici, nous devons spécifier chaque événement démographique survenu durant l&#39;histoire passée des sous-populations,</span>
<span class="c1"># ainsi que leur taille efficace, les flux de migrations et les taux de recombinaison):</span>
<span class="c1"># -------------------------------------------------------------------------------------------</span>

<span class="n">Ne_demo</span> <span class="o">=</span> <span class="p">(</span><span class="n">s</span><span class="o">.</span><span class="n">harmonic_mean</span><span class="p">(</span><span class="n">SLiM_demo</span><span class="p">[</span><span class="s1">&#39;ne_demo&#39;</span><span class="p">]))</span><span class="o">/</span><span class="mi">2</span> <span class="c1"># Taille efficace par sous-population.</span>
<span class="c1"># La taille efficace démographique Ne_demo sera ici utilisée comme proxy de la taille efficace de coalescence.</span>
<span class="n">gen_time</span> <span class="o">=</span> <span class="p">(</span><span class="n">s</span><span class="o">.</span><span class="n">harmonic_mean</span><span class="p">(</span><span class="n">SLiM_demo</span><span class="p">[</span><span class="s1">&#39;gen_time&#39;</span><span class="p">]))</span>
<span class="nb">print</span><span class="p">(</span><span class="s2">&quot;Mean, per-generation effective size obtained from SLiM reproductive outputs is &quot;</span><span class="p">,</span> <span class="n">Ne_demo</span><span class="p">,</span> <span class="s2">&quot;. Generation time is &quot;</span><span class="p">,</span> <span class="n">gen_time</span><span class="p">,</span> <span class="s2">&quot;.&quot;</span><span class="p">)</span>

<span class="n">Ne_pyslim</span> <span class="o">=</span> <span class="n">Ne_demo</span><span class="o">*</span><span class="n">gen_time</span> <span class="c1"># Re-échelonnage de la taille efficace par génération de Wright-Fisher pour chaque sous-population. </span>
<span class="n">t_split</span> <span class="o">=</span> <span class="mi">4</span><span class="o">*</span><span class="n">Ne_pyslim</span> <span class="c1"># On fixe le temps de divergence entre sous-populations de manière à favoriser l&#39;équilibre migration-dérive.</span>

<span class="c1"># Initialisation des taux de recombinaison par section de chromosome: </span>
<span class="n">r_chrom</span> <span class="o">=</span> <span class="mf">1.435e-9</span> <span class="c1"># Re-échelonnage du taux de recombinaison par génération de Wright-Fisher.</span>
<span class="n">r_break</span> <span class="o">=</span> <span class="n">math</span><span class="o">.</span><span class="n">log</span><span class="p">(</span><span class="mi">2</span><span class="p">)</span>
<span class="n">chrom_positions</span> <span class="o">=</span> <span class="p">[</span><span class="mi">0</span><span class="p">,</span> <span class="mi">400000000</span><span class="p">,</span> <span class="mi">800000000</span><span class="p">,</span> <span class="mi">1200000000</span><span class="p">,</span> <span class="mi">1600000000</span><span class="p">,</span> <span class="mi">2000000000</span><span class="p">]</span>
<span class="n">map_positions</span> <span class="o">=</span> <span class="p">[</span><span class="n">chrom_positions</span><span class="p">[</span><span class="mi">0</span><span class="p">],</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">1</span><span class="p">],</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">1</span><span class="p">]</span> <span class="o">+</span> <span class="mi">1</span><span class="p">,</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">2</span><span class="p">],</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">2</span><span class="p">]</span> <span class="o">+</span> <span class="mi">1</span><span class="p">,</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">3</span><span class="p">],</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">3</span><span class="p">]</span> <span class="o">+</span> <span class="mi">1</span><span class="p">,</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">4</span><span class="p">],</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">4</span><span class="p">]</span> <span class="o">+</span> <span class="mi">1</span><span class="p">,</span> <span class="n">chrom_positions</span><span class="p">[</span><span class="mi">5</span><span class="p">]]</span>
<span class="n">rates</span> <span class="o">=</span> <span class="p">[</span><span class="n">r_chrom</span><span class="p">,</span> <span class="n">r_break</span><span class="p">,</span> <span class="n">r_chrom</span><span class="p">,</span> <span class="n">r_break</span><span class="p">,</span> <span class="n">r_chrom</span><span class="p">,</span> <span class="n">r_break</span><span class="p">,</span> <span class="n">r_chrom</span><span class="p">,</span> <span class="n">r_break</span><span class="p">,</span> <span class="n">r_chrom</span><span class="p">]</span>
<span class="n">rate_map</span> <span class="o">=</span> <span class="n">msprime</span><span class="o">.</span><span class="n">RateMap</span><span class="p">(</span><span class="n">position</span><span class="o">=</span><span class="n">map_positions</span><span class="p">,</span> <span class="n">rate</span><span class="o">=</span><span class="n">rates</span><span class="p">)</span>

<span class="c1"># Initialisation des informations démographiques et définition de la trajectoire évolutive passée: </span>
<span class="n">demography</span> <span class="o">=</span> <span class="n">msprime</span><span class="o">.</span><span class="n">Demography</span><span class="o">.</span><span class="n">from_tree_sequence</span><span class="p">(</span><span class="n">ts</span><span class="p">)</span>
<span class="k">for</span> <span class="n">pop</span> <span class="ow">in</span> <span class="n">demography</span><span class="o">.</span><span class="n">populations</span><span class="p">:</span>
    <span class="k">if</span> <span class="n">pop</span><span class="o">.</span><span class="n">name</span> <span class="ow">in</span> <span class="p">(</span><span class="s1">&#39;p1&#39;</span><span class="p">,</span> <span class="s1">&#39;p2&#39;</span><span class="p">):</span>
        <span class="n">pop</span><span class="o">.</span><span class="n">initial_size</span> <span class="o">=</span> <span class="n">Ne_pyslim</span> <span class="c1"># Taille efficace locale de chaque sous-population.</span>
    <span class="k">else</span><span class="p">:</span>
        <span class="n">pop</span><span class="o">.</span><span class="n">initial_size</span> <span class="o">=</span> <span class="mi">2</span><span class="o">*</span><span class="n">Ne_pyslim</span> <span class="c1"># Taille efficace de la population ancestrale &quot;pop_0&quot;, avant divergence.</span>
<span class="c1"># demography.add_population(name=&quot;pop_anc&quot;, initial_size= int(Ne_pyslim*2)) </span>
<span class="c1"># La ligne de code ci-dessus générait un bug décrit ici: https://groups.google.com/g/slim-discuss/c/WA-c1hUWgIY.</span>
<span class="c1"># En réalité, pour insérer une nouvelle population non-existante au tree sequence, nous devons initialiser ses métadonnées manuellement comme expliqué par P.Ralph dans l&#39;URL ci-dessus.</span>
<span class="c1"># Ici, on tire donc finalement parti de la population vide &quot;pop_0&quot; automatiquement présente dans le tree sequence. Elle deviendra notre population ancestrale.</span>
<span class="n">demography</span><span class="o">.</span><span class="n">add_population_split</span><span class="p">(</span><span class="n">time</span><span class="o">=</span><span class="n">t_split</span><span class="p">,</span> <span class="n">derived</span><span class="o">=</span><span class="p">[</span><span class="s2">&quot;p1&quot;</span><span class="p">,</span> <span class="s2">&quot;p2&quot;</span><span class="p">],</span> <span class="n">ancestral</span><span class="o">=</span><span class="s2">&quot;pop_0&quot;</span><span class="p">)</span> <span class="c1"># Divergence entre les sous-populations.</span>
<span class="n">demography</span><span class="o">.</span><span class="n">set_symmetric_migration_rate</span><span class="p">(</span><span class="n">populations</span><span class="o">=</span><span class="p">[</span><span class="s2">&quot;p1&quot;</span><span class="p">,</span> <span class="s2">&quot;p2&quot;</span><span class="p">],</span> <span class="n">rate</span><span class="o">=</span><span class="n">migrate</span><span class="p">)</span> <span class="c1"># Définition des flux de migration entre les sous-populations.   </span>

<span class="n">debug</span> <span class="o">=</span> <span class="n">demography</span><span class="o">.</span><span class="n">debug</span><span class="p">()</span> <span class="c1"># Ce module nous permet de visualiser la trajectoire évolutive modélisée précédemment pour vérification.</span>
<span class="nb">print</span><span class="p">(</span><span class="n">debug</span><span class="p">)</span>
<span class="n">mod</span> <span class="o">=</span> <span class="n">demography</span><span class="o">.</span><span class="n">to_demes</span><span class="p">()</span>
<span class="n">ax</span> <span class="o">=</span> <span class="n">demesdraw</span><span class="o">.</span><span class="n">tubes</span><span class="p">(</span><span class="n">mod</span><span class="p">)</span>

<span class="c1"># ON PEUT ALORS LANCER LA RECAPITATION:</span>
<span class="n">rts</span> <span class="o">=</span> <span class="n">pyslim</span><span class="o">.</span><span class="n">recapitate</span><span class="p">(</span><span class="n">ts</span><span class="p">,</span> <span class="n">demography</span><span class="o">=</span><span class="n">demography</span><span class="p">,</span> <span class="n">recombination_rate</span><span class="o">=</span><span class="n">rate_map</span><span class="p">,</span> <span class="n">random_seed</span><span class="o">=</span><span class="mi">1</span><span class="p">)</span>
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<pre>Mean, per-generation effective size obtained from SLiM reproductive outputs is  2772.0601826540315 . Generation time is  6.988647213350303 .
DemographyDebugger
╠═════════════════════════════════════╗
║ Epoch[0]: [0, 7.75e+04) generations ║
╠═════════════════════════════════════╝
╟    Populations (total=3 active=2)
║    ┌──────────────────────────────────────────────────────┐
║    │    │     start│       end│growth_rate  │  p1  │  p2  │
║    ├──────────────────────────────────────────────────────┤
║    │  p1│   19373.0│   19373.0│ 0           │  0   │ 0.05 │
║    │  p2│   19373.0│   19373.0│ 0           │ 0.05 │  0   │
║    └──────────────────────────────────────────────────────┘
╟    Events @ generation 7.75e+04
║    ┌─────────────────────────────────────────────────────────────────────────────────────┐
║    │       time│type        │parameters         │effect                                  │
║    ├─────────────────────────────────────────────────────────────────────────────────────┤
║    │  7.749e+04│Population  │derived=[p1, p2],  │Moves all lineages from derived         │
║    │           │Split       │ancestral=pop_0    │populations &#39;p1&#39; and &#39;p2&#39; to the        │
║    │           │            │                   │ancestral &#39;pop_0&#39; population. Also set  │
║    │           │            │                   │the derived populations to inactive,    │
║    │           │            │                   │and all migration rates to and from     │
║    │           │            │                   │the derived populations to zero.        │
║    └─────────────────────────────────────────────────────────────────────────────────────┘
╠═══════════════════════════════════════╗
║ Epoch[1]: [7.75e+04, inf) generations ║
╠═══════════════════════════════════════╝
╟    Populations (total=3 active=1)
║    ┌───────────────────────────────────────────┐
║    │       │     start│       end│growth_rate  │
║    ├───────────────────────────────────────────┤
║    │  pop_0│   38745.9│   38745.9│ 0           │
║    └───────────────────────────────────────────┘

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<pre>/home2/datawork/cdelord/conda-env/simupop-slim/lib/python3.7/site-packages/msprime/ancestry.py:831: TimeUnitsMismatchWarning: The initial_state has time_units=ticks but time is measured in generations in msprime. This may lead to significant discrepancies between the timescales. If you wish to suppress this warning, you can use, e.g., warnings.simplefilter(&#39;ignore&#39;, msprime.TimeUnitsMismatchWarning)
  warnings.warn(message, TimeUnitsMismatchWarning)
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<p>Script <code>POPSIZE_pyslim_Cohort5000_m005.py</code> <strong>(Partie 4/7)</strong></p>
<p>Suite à notre phase de récapitation, il s'agit de vérifier que les généalogies de gènes de notre <strong>tree sequence</strong> ont, cette fois-ci, trouvé leur TMRCA, et donc que la coalescence est complète tout le long du génome. Nous pouvons visualiser de nouveau la distribution des temps de coalescence de long du génome et constater que "le temps moyen de coalescence, divisé par 4, donne 39747.89704852677" ce qui correspond à peu près à la valeur de taille efficace de la population ancestrale (et à la somme des tailles efficaces des sous-populations) telles que fixées dans <em>pyslim</em>.</p>
<p>La fonction <code>print(rts)</code> nous permet de visualiser quelques informations sur ce <strong>tree sequence</strong> après récapitation. Par rapport à sa version précédente, il contient des arbres plus "denses" (valeur <code>Edges</code> et <code>Nodes</code>) et des généalogies plus nombreuses.</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Affichage des informations principales du tree sequence, après récapitation.</span>
<span class="nb">print</span><span class="p">(</span><span class="n">rts</span><span class="p">)</span>
<span class="k">assert</span><span class="p">(</span><span class="nb">max</span><span class="p">([</span><span class="n">t</span><span class="o">.</span><span class="n">num_roots</span> <span class="k">for</span> <span class="n">t</span> <span class="ow">in</span> <span class="n">rts</span><span class="o">.</span><span class="n">trees</span><span class="p">()])</span> <span class="o">==</span> <span class="mi">1</span><span class="p">)</span>

<span class="c1"># Visualisation de la taille (en générations) des arbres de coalescences après récapitation. </span>
<span class="c1"># A présent, elle devrait varier entre loci car tous n&#39;auront pas le même temps de coalescence (TMRCA).</span>
<span class="n">breakpoints</span> <span class="o">=</span> <span class="nb">list</span><span class="p">(</span><span class="n">rts</span><span class="o">.</span><span class="n">breakpoints</span><span class="p">())</span>
<span class="n">heights</span> <span class="o">=</span> <span class="n">tree_heights</span><span class="p">(</span><span class="n">rts</span><span class="p">)</span>
<span class="nb">print</span><span class="p">(</span><span class="s1">&#39;Le temps moyen de coalescence, divisé par 4, donne &#39;</span><span class="p">,</span> <span class="n">np</span><span class="o">.</span><span class="n">mean</span><span class="p">(</span><span class="n">heights</span><span class="p">)</span><span class="o">/</span><span class="mi">4</span><span class="p">)</span>
<span class="n">plt</span><span class="o">.</span><span class="n">step</span><span class="p">(</span><span class="n">breakpoints</span><span class="p">,</span> <span class="n">heights</span><span class="p">,</span> <span class="n">where</span><span class="o">=</span><span class="s1">&#39;post&#39;</span><span class="p">)</span>
<span class="n">plt</span><span class="o">.</span><span class="n">show</span><span class="p">()</span>
<span class="n">plt</span><span class="o">.</span><span class="n">savefig</span><span class="p">(</span><span class="s1">&#39;pyslim_tree_height1_Cohort</span><span class="si">%s</span><span class="s1">_</span><span class="si">%s</span><span class="s1">.png&#39;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">))</span>

<span class="c1"># On vérifier que suite à la récapitation, tous les arbres convergent vers une même racine.</span>
<span class="n">orig_max_roots</span> <span class="o">=</span> <span class="nb">max</span><span class="p">(</span><span class="n">t</span><span class="o">.</span><span class="n">num_roots</span> <span class="k">for</span> <span class="n">t</span> <span class="ow">in</span> <span class="n">ts</span><span class="o">.</span><span class="n">trees</span><span class="p">())</span>
<span class="n">recap_max_roots</span> <span class="o">=</span> <span class="nb">max</span><span class="p">(</span><span class="n">t</span><span class="o">.</span><span class="n">num_roots</span> <span class="k">for</span> <span class="n">t</span> <span class="ow">in</span> <span class="n">rts</span><span class="o">.</span><span class="n">trees</span><span class="p">())</span>
<span class="nb">print</span><span class="p">(</span><span class="n">f</span><span class="s2">&quot;Nombre de racines distinctes avant récapitation: </span><span class="si">{orig_max_roots}</span><span class="se">\n</span><span class="s2">&quot;</span>
      <span class="n">f</span><span class="s2">&quot;Nombre de racines distinctes après récapitation: </span><span class="si">{recap_max_roots}</span><span class="s2">&quot;</span><span class="p">)</span>
<span class="n">rts</span><span class="o">.</span><span class="n">dump</span><span class="p">(</span><span class="s2">&quot;POPSIZE_pyslim_Cohort</span><span class="si">%s</span><span class="s2">_</span><span class="si">%s</span><span class="s2">_rts.trees&quot;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">))</span>

<span class="c1"># Visualisation de l&#39;évolution des taux de coalescence au cours du temps:</span>
<span class="k">def</span> <span class="nf">count_tree_coalescence_pairs</span><span class="p">(</span><span class="n">ts</span><span class="p">,</span> <span class="n">epochs</span><span class="p">):</span>
    <span class="n">nepochs</span> <span class="o">=</span> <span class="nb">len</span><span class="p">(</span><span class="n">epochs</span><span class="p">)</span>
    <span class="n">times</span> <span class="o">=</span> <span class="nb">dict</span><span class="p">()</span>
    <span class="k">for</span> <span class="n">tr</span> <span class="ow">in</span> <span class="n">ts</span><span class="o">.</span><span class="n">trees</span><span class="p">():</span>
        <span class="k">for</span> <span class="n">node</span> <span class="ow">in</span> <span class="n">tr</span><span class="o">.</span><span class="n">nodes</span><span class="p">():</span>
            <span class="k">if</span> <span class="n">tr</span><span class="o">.</span><span class="n">is_leaf</span><span class="p">(</span><span class="n">node</span><span class="p">):</span>
                <span class="k">continue</span>
            <span class="n">nlineages</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">array</span><span class="p">([</span><span class="n">tr</span><span class="o">.</span><span class="n">num_samples</span><span class="p">(</span><span class="n">child</span><span class="p">)</span> <span class="k">for</span> <span class="n">child</span> <span class="ow">in</span> <span class="n">tr</span><span class="o">.</span><span class="n">children</span><span class="p">(</span><span class="n">node</span><span class="p">)])</span>
            <span class="n">ns</span> <span class="o">=</span> <span class="n">functools</span><span class="o">.</span><span class="n">reduce</span><span class="p">(</span><span class="k">lambda</span> <span class="n">s</span><span class="p">,</span> <span class="n">t</span><span class="p">:</span> <span class="n">s</span> <span class="o">+</span> <span class="n">t</span><span class="p">,</span> <span class="p">(</span><span class="n">x</span><span class="o">*</span><span class="n">y</span> <span class="k">for</span> <span class="n">x</span><span class="p">,</span> <span class="n">y</span> <span class="ow">in</span> <span class="n">itertools</span><span class="o">.</span><span class="n">combinations</span><span class="p">(</span><span class="n">nlineages</span><span class="p">,</span> <span class="mi">2</span><span class="p">)))</span> 
            <span class="n">t</span> <span class="o">=</span> <span class="n">tr</span><span class="o">.</span><span class="n">time</span><span class="p">(</span><span class="n">node</span><span class="p">)</span>
            <span class="n">times</span><span class="p">[</span><span class="n">t</span><span class="p">]</span> <span class="o">=</span> <span class="n">ns</span> <span class="o">+</span> <span class="n">times</span><span class="o">.</span><span class="n">get</span><span class="p">(</span><span class="n">t</span><span class="p">,</span> <span class="mi">0</span><span class="p">)</span> 
    <span class="n">counts</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">fromiter</span><span class="p">(</span><span class="n">times</span><span class="o">.</span><span class="n">values</span><span class="p">(),</span> <span class="n">dtype</span><span class="o">=</span><span class="nb">int</span><span class="p">)</span>
    <span class="n">times</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">fromiter</span><span class="p">(</span><span class="n">times</span><span class="o">.</span><span class="n">keys</span><span class="p">(),</span> <span class="n">dtype</span><span class="o">=</span><span class="nb">float</span><span class="p">)</span>
    <span class="n">indices</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">digitize</span><span class="p">(</span><span class="n">times</span><span class="p">,</span> <span class="n">epochs</span><span class="p">)</span>
    <span class="n">coalesced</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">zeros</span><span class="p">(</span><span class="n">shape</span><span class="o">=</span><span class="n">nepochs</span><span class="p">)</span> 
    <span class="n">np</span><span class="o">.</span><span class="n">add</span><span class="o">.</span><span class="n">at</span><span class="p">(</span><span class="n">coalesced</span><span class="p">,</span> <span class="n">indices</span><span class="p">,</span> <span class="n">counts</span><span class="p">)</span>
    <span class="n">total</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">cumsum</span><span class="p">(</span><span class="n">coalesced</span><span class="p">[::</span><span class="o">-</span><span class="mi">1</span><span class="p">])[::</span><span class="o">-</span><span class="mi">1</span><span class="p">]</span>    
    <span class="c1">#counts = count_tree_coalescence_pairs(mts, bins)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">figure</span><span class="p">(</span><span class="mi">1</span><span class="p">)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">plot</span><span class="p">(</span><span class="n">epochs</span><span class="p">[:</span><span class="o">-</span><span class="mi">1</span><span class="p">],</span> <span class="n">coalesced</span><span class="p">[</span><span class="mi">1</span><span class="p">:])</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">xlabel</span><span class="p">(</span><span class="s2">&quot;Nombre de générations avant présent (en bins de 100 générations)&quot;</span><span class="p">)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">ylabel</span><span class="p">(</span><span class="s2">&quot;Nombre d&#39;événements de coalescence&quot;</span><span class="p">)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">savefig</span><span class="p">(</span><span class="s2">&quot;Fig_noCoalescedPairsCohort</span><span class="si">%s</span><span class="s2">_</span><span class="si">%s</span><span class="s2">.png&quot;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">),</span> <span class="n">bbox_inches</span><span class="o">=</span><span class="s2">&quot;tight&quot;</span><span class="p">)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">show</span><span class="p">()</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">figure</span><span class="p">(</span><span class="mi">2</span><span class="p">)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">plot</span><span class="p">(</span><span class="n">epochs</span><span class="p">[:</span><span class="o">-</span><span class="mi">1</span><span class="p">],</span> <span class="n">total</span><span class="p">[</span><span class="mi">1</span><span class="p">:]</span><span class="o">-</span><span class="n">coalesced</span><span class="p">[</span><span class="mi">1</span><span class="p">:])</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">xlabel</span><span class="p">(</span><span class="s2">&quot;Nombre de générations avant présent (en bins de 100 générations)&quot;</span><span class="p">)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">ylabel</span><span class="p">(</span><span class="s2">&quot;Proportion de lignées ancestrales restantes&quot;</span><span class="p">)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">savefig</span><span class="p">(</span><span class="s2">&quot;Fig_propAncestralLineages_Cohort</span><span class="si">%s</span><span class="s2">_</span><span class="si">%s</span><span class="s2">_simR_</span><span class="si">%s</span><span class="s2">.png&quot;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">,</span> <span class="n">rep</span><span class="p">),</span> <span class="n">bbox_inches</span><span class="o">=</span><span class="s2">&quot;tight&quot;</span><span class="p">)</span>
    <span class="n">plt</span><span class="o">.</span><span class="n">show</span><span class="p">()</span>
    <span class="k">return</span> <span class="n">coalesced</span><span class="p">[</span><span class="mi">1</span><span class="p">:],</span> <span class="n">total</span><span class="p">[</span><span class="mi">1</span><span class="p">:],</span> <span class="n">epochs</span>
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<pre>╔══════════════════════════╗
║TreeSequence              ║
╠═══════════════╤══════════╣
║Trees          │   5787202║
╟───────────────┼──────────╢
║Sequence Length│2000000000║
╟───────────────┼──────────╢
║Time Units     │     ticks║
╟───────────────┼──────────╢
║Sample Nodes   │     73042║
╟───────────────┼──────────╢
║Total Size     │ 753.3 MiB║
╚═══════════════╧══════════╝
╔═══════════╤════════╤═════════╤════════════╗
║Table      │Rows    │Size     │Has Metadata║
╠═══════════╪════════╪═════════╪════════════╣
║Edges      │18083512│551.9 MiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Individuals│   36521│  3.5 MiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Migrations │       0│  8 Bytes│          No║
╟───────────┼────────┼─────────┼────────────╢
║Mutations  │       0│  1.2 KiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Nodes      │ 2188851│ 59.9 MiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Populations│       3│  2.3 KiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Provenances│       2│ 14.4 KiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Sites      │       0│ 16 Bytes│          No║
╚═══════════╧════════╧═════════╧════════════╝

Le temps moyen de coalescence, divisé par 4, donne  39747.89704852677
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<pre>Nombre de racines distinctes avant récapitation: 1636
Nombre de racines distinctes après récapitation: 1
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<pre>&lt;Figure size 432x288 with 0 Axes&gt;</pre>
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<p>Script <code>POPSIZE_pyslim_Cohort5000_m005.py</code> <strong>(Partie 5/7)</strong></p>
<p>Nous allons maintenant procéder à la phase dite de "simplification". La simplification va nous permettre de "débroussailler" notre <strong>tree sequence</strong>. En effet, suite à sa récapitation, celui-ci est très lourd et très dense mais, surtout, nous n'avons pas besoin de connaître l'information génétique de tous les individus vivants au temps présent (qui, à ce stade, sont toujours intégrés au <strong>tree sequence</strong> puisqu'exportés par défaut à la fin de l'étape n°1). En effet, seule l'information génétique des individus échantillonnés dans SLiM entre les pas de temps 90 à 100 nous intéresse. Le processus de simplification va nous permettre de ne conserver, dans notre <strong>tree sequence</strong>, que les généalogies relatives à ces individus et dont les identifiants uniques, conservés dans notre fichier <code>SLiM_samples.tsv</code>, peuvent également être retrouvés dans le <strong>tree sequence</strong>.</p>
<p>La fonction <code>print(sts)</code> nous permet de visualiser quelques informations sur ce <strong>tree sequence</strong> après simplification. Par rapport à sa version précédente, il contient des arbres moins "denses" (valeur <code>Edges</code> et <code>Nodes</code>) et des généalogies moins nombreuses. Surtout, il contient un nombre bien moindre d'individus, plus précisément 14978. Cette valeur est très proche du nombre de 14856 individus échantillonnés au cours de l'étape n°1. La légère différence provient du fait que certains individus présents dans le <strong>tree sequence</strong> ne faisaient pas partie de notre échantillon mais ont été conservés (de manière automatique) par <em>pyslim</em>, car impliqués dans les généalogies de notre échantillon.</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># -------------------------------------------------------------------------------------------</span>
<span class="c1"># SIMPLIFICATION (ici, nous devons spécifier l&#39;identité des &quot;noeuds&quot; associés aux individus qui ont été mémorisés </span>
<span class="c1"># au cours de l&#39;échantillonnage à l&#39;étape n°1 grâce à la fonction &quot;sim.treeSeqRememberIndividuals();&quot; de SLiM.).</span>
<span class="c1"># -------------------------------------------------------------------------------------------</span>

<span class="c1"># Importation des identifiants de tous les individus échantillonnés au cours de l&#39;étape n°1, stockés dans le fichier &quot;SLiM_samples.tsv&quot;. </span>
<span class="c1"># Nous allons utiliser cette information pour simplifier notre &quot;tree sequence&quot; suite à sa récapitation.</span>
<span class="n">samples0</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">read_csv</span><span class="p">(</span><span class="s2">&quot;SLiM_samples.tsv&quot;</span><span class="p">,</span> <span class="n">delimiter</span><span class="o">=</span><span class="s2">&quot;</span><span class="se">\t</span><span class="s2">&quot;</span><span class="p">,</span> <span class="n">header</span><span class="o">=</span><span class="mi">0</span><span class="p">)</span>
<span class="n">samples</span> <span class="o">=</span> <span class="n">samples0</span><span class="o">.</span><span class="n">drop_duplicates</span><span class="p">(</span><span class="n">subset</span><span class="o">=</span><span class="s1">&#39;ID&#39;</span><span class="p">,</span> <span class="n">keep</span><span class="o">=</span><span class="s1">&#39;first&#39;</span><span class="p">,</span> <span class="n">inplace</span><span class="o">=</span><span class="kc">False</span><span class="p">,</span> <span class="n">ignore_index</span><span class="o">=</span><span class="kc">True</span><span class="p">)</span> <span class="c1"># Nous n&#39;avons besoin que des identifiants uniques, même si certains individus ont pu être échantillonnés plusieurs fois.</span>
<span class="n">samples</span><span class="p">[</span><span class="s1">&#39;pid&#39;</span><span class="p">]</span> <span class="o">=</span> <span class="n">samples</span><span class="o">.</span><span class="n">ID</span><span class="o">.</span><span class="n">str</span><span class="o">.</span><span class="n">split</span><span class="p">(</span><span class="s2">&quot;_&quot;</span><span class="p">)</span><span class="o">.</span><span class="n">str</span><span class="p">[</span><span class="mi">2</span><span class="p">]</span>
<span class="n">samp_ped</span> <span class="o">=</span> <span class="n">samples</span><span class="o">.</span><span class="n">pid</span><span class="o">.</span><span class="n">astype</span><span class="p">(</span><span class="nb">int</span><span class="p">)</span><span class="o">.</span><span class="n">tolist</span><span class="p">()</span>

<span class="c1"># Création d&#39;une liste vide pour stocker les identifiants pyslim de chaque individu correspondant aux identifiants SLiM (pedigree_id) des échantillons de samp_ped.</span>
<span class="n">keep_indivs</span> <span class="o">=</span> <span class="p">[]</span> 
<span class="k">for</span> <span class="n">i</span> <span class="ow">in</span> <span class="n">rts</span><span class="o">.</span><span class="n">individuals</span><span class="p">():</span>
    <span class="n">pid</span> <span class="o">=</span> <span class="n">i</span><span class="o">.</span><span class="n">metadata</span><span class="p">[</span><span class="s2">&quot;pedigree_id&quot;</span><span class="p">]</span>
    <span class="k">if</span> <span class="n">pid</span> <span class="ow">in</span> <span class="n">samp_ped</span><span class="p">:</span>
        <span class="n">keep_indivs</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">i</span><span class="o">.</span><span class="n">id</span><span class="p">)</span>

<span class="c1"># Le nombre d&#39;individus présents dans samp_ped et dans keep_indiv doit être identique:</span>
<span class="nb">print</span><span class="p">(</span><span class="s1">&#39;Notre fichier SLiM_samples.tsv contient &#39;</span><span class="p">,</span> <span class="nb">len</span><span class="p">(</span><span class="n">samp_ped</span><span class="p">),</span> <span class="s1">&#39; échantillons avec un identifiant SLiM pedigree_IDs, et notre liste keep_indivs contient &#39;</span><span class="p">,</span> <span class="nb">len</span><span class="p">(</span><span class="n">keep_indivs</span><span class="p">),</span> <span class="s1">&#39; échantillons avec un identifiant pyslim individual.id.&#39;</span><span class="p">,</span> <span class="n">sep</span><span class="o">=</span><span class="s1">&#39;&#39;</span><span class="p">)</span>

<span class="c1"># Création d&#39;une liste vide pour stocker les identifiants des noeuds (pyslim) associés aux échantillons de keep_indivs.</span>
<span class="n">keep_nodes</span> <span class="o">=</span> <span class="p">[]</span> 
<span class="k">for</span> <span class="n">i</span> <span class="ow">in</span> <span class="n">keep_indivs</span><span class="p">:</span>
    <span class="n">keep_nodes</span><span class="o">.</span><span class="n">extend</span><span class="p">(</span><span class="n">rts</span><span class="o">.</span><span class="n">individual</span><span class="p">(</span><span class="n">i</span><span class="p">)</span><span class="o">.</span><span class="n">nodes</span><span class="p">)</span>

<span class="c1"># ON PEUT ALORS LANCER LA SIMPLIFICATION: </span>
<span class="c1"># en conservant uniquement, dans notre &quot;tree sequence&quot;, les individus dont l&#39;identifiant correspondent aux individus échantillonnés au cours de l&#39;étape n°1 (keep_nodes).</span>
<span class="c1"># Nous éliminons les autres individus qui étaient vivants au temps présent (i.e., dans la dernière génération simulée dans SLiM).</span>
<span class="n">sts</span> <span class="o">=</span> <span class="n">rts</span><span class="o">.</span><span class="n">simplify</span><span class="p">(</span><span class="n">keep_nodes</span><span class="p">)</span> 
<span class="nb">print</span><span class="p">(</span><span class="n">sts</span><span class="p">)</span>
<span class="n">sts</span><span class="o">.</span><span class="n">dump</span><span class="p">(</span><span class="s2">&quot;POPSIZE_pyslim_Cohort</span><span class="si">%s</span><span class="s2">_</span><span class="si">%s</span><span class="s2">_sts.trees&quot;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">))</span>
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<pre>/home2/datawork/cdelord/conda-env/simupop-slim/lib/python3.7/site-packages/ipykernel/__main__.py:10: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame.
Try using .loc[row_indexer,col_indexer] = value instead

See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy
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<pre>Notre fichier SLiM_samples.tsv contient 14856 échantillons avec un identifiant SLiM pedigree_IDs, et notre liste keep_indivs contient 14856 échantillons avec un identifiant pyslim individual.id.
╔══════════════════════════╗
║TreeSequence              ║
╠═══════════════╤══════════╣
║Trees          │   4827996║
╟───────────────┼──────────╢
║Sequence Length│2000000000║
╟───────────────┼──────────╢
║Time Units     │     ticks║
╟───────────────┼──────────╢
║Sample Nodes   │     29712║
╟───────────────┼──────────╢
║Total Size     │ 694.0 MiB║
╚═══════════════╧══════════╝
╔═══════════╤════════╤═════════╤════════════╗
║Table      │Rows    │Size     │Has Metadata║
╠═══════════╪════════╪═════════╪════════════╣
║Edges      │16636023│507.7 MiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Individuals│   14978│  1.4 MiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Migrations │       0│  8 Bytes│          No║
╟───────────┼────────┼─────────┼────────────╢
║Mutations  │       0│  1.2 KiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Nodes      │ 2132052│ 57.9 MiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Populations│       3│  2.3 KiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Provenances│       3│ 14.9 KiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Sites      │       0│ 16 Bytes│          No║
╚═══════════╧════════╧═════════╧════════════╝

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<p>Script <code>POPSIZE_pyslim_Cohort5000_m005.py</code> <strong>(Partie 6/7)</strong></p>
<p>Il nous reste à présent à ajouter de la variabilité génétique à notre <strong>tree sequence</strong>. Nous pouvons utiliser un modèle de mutation classique (ici <code>msprime.JC69()</code>, le modèle de Jukes et Cantor, 1969).</p>
<p>La fonction <code>print(mts)</code> nous permet de visualiser quelques informations sur ce <strong>tree sequence</strong> après ajout de mutations. Le nombre de <code>Sites</code> et de <code>Mutations</code>, toujours égaux à zéro dans les versions précédentes, sont maintenant passés à 5.098e06 et 5.105e06, respectivement (certains sites variables portent donc plus d'une mutation).</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># -------------------------------------------------------------------------------------------</span>
<span class="c1"># ADDITION DE VARIABILITE GENETIQUE NEUTRE (OVERLAY/MUTATE)</span>
<span class="c1"># (La diversité génétique neutre est répartie, sous forme de l&#39;ajout de variants, le long du &quot;tree sequence&quot;).</span>
<span class="c1"># Par la suite, nous pourrons ainsi exporter des génotypes pour chaque individu échantillonné dans SLiM. </span>
<span class="c1"># -------------------------------------------------------------------------------------------</span>

<span class="n">mts</span> <span class="o">=</span> <span class="n">pyslim</span><span class="o">.</span><span class="n">SlimTreeSequence</span><span class="p">(</span><span class="n">msprime</span><span class="o">.</span><span class="n">sim_mutations</span><span class="p">(</span><span class="n">sts</span><span class="p">,</span> <span class="n">rate</span><span class="o">=</span><span class="mf">1.435e-09</span><span class="p">,</span> <span class="n">model</span><span class="o">=</span><span class="n">msprime</span><span class="o">.</span><span class="n">JC69</span><span class="p">(),</span> <span class="n">keep</span><span class="o">=</span><span class="kc">True</span><span class="p">))</span>
<span class="c1"># Re-échelonnage du taux de mutation par génération de Wright-Fisher: &#39;rate=1.435e-09&#39;.</span>
<span class="nb">print</span><span class="p">(</span><span class="n">f</span><span class="s2">&quot;Notre tree sequence comporte maintenant </span><span class="si">{mts.num_sites}</span><span class="s2"> sites variables, </span><span class="si">{mts.num_mutations}</span><span class="s2"> mutations,</span><span class="se">\n</span><span class="s2">&quot;</span>
      <span class="n">f</span><span class="s2">&quot;et la diversité nucléotidique moyenne est de {mts.diversity():0.3e}.&quot;</span><span class="p">)</span>
<span class="nb">print</span><span class="p">(</span><span class="n">mts</span><span class="p">)</span>
<span class="n">mts</span><span class="o">.</span><span class="n">dump</span><span class="p">(</span><span class="s2">&quot;POPSIZE_pyslim_Cohort</span><span class="si">%s</span><span class="s2">_</span><span class="si">%s</span><span class="s2">_mts.trees&quot;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">))</span>
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<pre>Notre tree sequence comporte maintenant 5104971 sites variables, 5111560 mutations,
et la diversité nucléotidique moyenne est de 2.221e-04.
╔══════════════════════════╗
║TreeSequence              ║
╠═══════════════╤══════════╣
║Trees          │   4827996║
╟───────────────┼──────────╢
║Sequence Length│2000000000║
╟───────────────┼──────────╢
║Time Units     │     ticks║
╟───────────────┼──────────╢
║Sample Nodes   │     29712║
╟───────────────┼──────────╢
║Total Size     │ 996.0 MiB║
╚═══════════════╧══════════╝
╔═══════════╤════════╤═════════╤════════════╗
║Table      │Rows    │Size     │Has Metadata║
╠═══════════╪════════╪═════════╪════════════╣
║Edges      │16636023│507.7 MiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Individuals│   14978│  1.4 MiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Migrations │       0│  8 Bytes│          No║
╟───────────┼────────┼─────────┼────────────╢
║Mutations  │ 5111560│180.4 MiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Nodes      │ 2132052│ 57.9 MiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Populations│       3│  2.3 KiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Provenances│       4│ 15.6 KiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Sites      │ 5104971│121.7 MiB│          No║
╚═══════════╧════════╧═════════╧════════════╝

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<p>Script <code>POPSIZE_pyslim_Cohort5000_m005.py</code> <strong>(Partie 7/7)</strong></p>
<p>Nous ne souhaitons pas exporter l'information génétique de tous les sites variables. Nous allons sélectionner un petit nombre de loci dont les caractéristiques nous conviennent. Nous n'exporterons que des sites bialléliques par exemple, et dont les fréquences alléliques sont suffisamment élevées pour être informatives. Ici, nous exportons un total de 30000 loci. Notre table de génotypes finale, exportée sous forme d'un fichier <em>"variant call format"</em> (.vcf) ; contiendra donc l'information génétique des 14856 individus échantillonnés au cours de l'étape n°1 avec leurs identifiants uniques (qui sont par ailleurs toujours conservés dans notre fichier <code>SLiM_samples.tsv</code> également) sur ces 30000 loci.</p>
<p>Ce fichier .vcf constitue donc la principale sortie de notre script <em>pyslim</em> et servira de base de référence à d'éventuels sous-échantillonnages d'individus (par exemple, pour ne travailler qu'avec les génotypes des individus d'un certain âge, capturés à un certain pas de temps, etc.) ou de loci (par exemple, en effectuant une sous-sélection de 1000 loci parmi les 30000 disponibles, ou en sélectionnant spécifiquement des loci issus d'une même section de chromosome). Ce type de post-traitement du fichier .vcf a été développé à l'aide du script R dédié <code>POPSIZE_vcf_output_processing.R</code>, qui s'appuie entre autres sur le fichier <code>SLiM_samples.tsv</code> et mobilise notamment les librairies <em>CKMRpop</em> et <em>dartR</em> pour manipuler les individus échantillonnés en fonction de différents critères, et générer des sous-fichiers .vcf (ou autres formats, e.g., PLINK) correspondant à des sous-sélections d'individus/de loci.</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># -------------------------------------------------------------------------------------------</span>
<span class="c1"># POST-TRAITEMENT DE NOTRE TREE-SEQUENCE ET EXTRACTION DE GENOTYPES.</span>
<span class="c1"># A présent que nous avons généré de la diversité génétique, nous pouvons exporter des tables de génotypes pour tout ou partie des individus échantillonnés dans SLiM:</span>
<span class="c1"># -------------------------------------------------------------------------------------------</span>

<span class="c1"># Diverses fonctions nous permettent de sélectionner les sites variables susceptibles de nous intéresser.</span>

<span class="c1"># Fonction pour le retrait des sites variables à plus de 2 allèles (on ne garde que les loci de type SNP biallélique).</span>
<span class="k">def</span> <span class="nf">removeMultiAllelic_global</span><span class="p">(</span><span class="n">mts</span><span class="p">):</span>
    <span class="n">sites_to_discard</span> <span class="o">=</span> <span class="p">[]</span>
    <span class="k">for</span> <span class="n">site</span> <span class="ow">in</span> <span class="n">mts</span><span class="o">.</span><span class="n">sites</span><span class="p">():</span>
        <span class="k">if</span> <span class="nb">len</span><span class="p">(</span><span class="n">site</span><span class="o">.</span><span class="n">mutations</span><span class="p">)</span> <span class="o">!=</span> <span class="mi">1</span><span class="p">:</span>
            <span class="n">sites_to_discard</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">site</span><span class="o">.</span><span class="n">id</span><span class="p">)</span>      
    <span class="n">mts_new</span> <span class="o">=</span> <span class="n">mts</span><span class="o">.</span><span class="n">delete_sites</span><span class="p">(</span><span class="n">sites_to_discard</span><span class="p">)</span>
    <span class="nb">print</span><span class="p">(</span><span class="n">mts_new</span><span class="o">.</span><span class="n">num_sites</span><span class="p">,</span> <span class="s2">&quot; sites restants après le retrait des loci à plus de 2 allèles.&quot;</span><span class="p">)</span>
    <span class="k">return</span> <span class="n">mts_new</span>

<span class="c1"># Fonction pour la sélection des variants en fonction de leur fréquence allélique minoritaire (MAF) sur l&#39;ensemble des individus échantillonnés.</span>
<span class="c1"># (Attention cependant, cette fonction n&#39;est pas encore optimale car elle considère tous les échantillons tous pas de temps confondus.)</span>
<span class="c1"># (Il faudrait pouvoir considérer les périodes d&#39;échantillonnages indépendamment les unes des autres pour bien réfléchir aux loci à sélectionner.)</span>
<span class="k">def</span> <span class="nf">removeRareVariants_global</span><span class="p">(</span><span class="n">mts</span><span class="p">,</span> <span class="n">minor_frequency</span><span class="p">):</span>
    <span class="n">sites_to_discard</span> <span class="o">=</span> <span class="p">[]</span>
    <span class="k">for</span> <span class="n">v</span> <span class="ow">in</span> <span class="n">mts</span><span class="o">.</span><span class="n">variants</span><span class="p">():</span>
        <span class="k">if</span> <span class="n">np</span><span class="o">.</span><span class="n">sum</span><span class="p">(</span><span class="n">v</span><span class="o">.</span><span class="n">genotypes</span><span class="p">[</span><span class="n">mts</span><span class="o">.</span><span class="n">samples</span><span class="p">()])</span> <span class="o">/</span> <span class="nb">len</span><span class="p">(</span><span class="n">mts</span><span class="o">.</span><span class="n">samples</span><span class="p">())</span> <span class="o">&lt;</span> <span class="n">minor_frequency</span><span class="p">:</span>
            <span class="n">sites_to_discard</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">v</span><span class="o">.</span><span class="n">site</span><span class="o">.</span><span class="n">id</span><span class="p">)</span>
    <span class="n">mts_new</span> <span class="o">=</span> <span class="n">mts</span><span class="o">.</span><span class="n">delete_sites</span><span class="p">(</span><span class="n">sites_to_discard</span><span class="p">)</span>
    <span class="nb">print</span><span class="p">(</span><span class="n">mts_new</span><span class="o">.</span><span class="n">num_sites</span><span class="p">,</span> <span class="s2">&quot; sites restants après le retrait des loci de MAF &lt; &quot;</span><span class="p">,</span> <span class="n">minor_frequency</span><span class="p">,</span> <span class="s2">&quot;.&quot;</span><span class="p">)</span>
    <span class="k">return</span> <span class="n">mts_new</span>

<span class="c1"># Fonction pour échantillonner un nombre &#39;num_loc&#39; de variants le long du génome afin d&#39;exporter ensuite leurs génotypes.</span>
<span class="k">def</span> <span class="nf">randomSitesSampler</span><span class="p">(</span><span class="n">mts</span><span class="p">,</span> <span class="n">num_loc</span><span class="p">,</span> <span class="n">span</span><span class="p">):</span>
    <span class="n">sites_to_discard</span> <span class="o">=</span> <span class="p">[]</span>
    <span class="k">if</span> <span class="n">span</span> <span class="o">&gt;</span> <span class="n">chromosomeSize</span><span class="p">:</span>
        <span class="n">span</span> <span class="o">=</span> <span class="n">chromosomeSize</span>
        <span class="nb">print</span><span class="p">(</span><span class="s2">&quot;Warning: la valeur span a été fixée égale à chromosomeSize, car elle excédait initialement cette valeur.&quot;</span><span class="p">)</span>
    <span class="k">for</span> <span class="n">site</span> <span class="ow">in</span> <span class="n">mts</span><span class="o">.</span><span class="n">sites</span><span class="p">():</span>
        <span class="k">if</span> <span class="n">site</span><span class="o">.</span><span class="n">position</span> <span class="o">&gt;</span> <span class="n">span</span><span class="o">-</span><span class="mi">1</span><span class="p">:</span>
            <span class="n">sites_to_discard</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">site</span><span class="o">.</span><span class="n">id</span><span class="p">)</span>        
    <span class="n">mts_new</span> <span class="o">=</span> <span class="n">mts</span><span class="o">.</span><span class="n">delete_sites</span><span class="p">(</span><span class="n">sites_to_discard</span><span class="p">)</span>
    <span class="n">sites_to_discard</span> <span class="o">=</span> <span class="p">[]</span>
    <span class="k">if</span> <span class="n">num_loc</span> <span class="o">&gt;</span> <span class="n">mts_new</span><span class="o">.</span><span class="n">num_sites</span><span class="p">:</span>
        <span class="n">num_loc</span> <span class="o">=</span>  <span class="n">mts_new</span><span class="o">.</span><span class="n">num_sites</span>
        <span class="nb">print</span><span class="p">(</span><span class="s2">&quot;Warning: la valeur num_loc value a été fixée égale à mts.num_sites, car elle excédait initialement le nombre de variants disponibles sur la longueur span.&quot;</span><span class="p">)</span>
        <span class="nb">print</span><span class="p">(</span><span class="s2">&quot;Le nombre de sites variables disponibles est de: &quot;</span><span class="p">,</span> <span class="n">mts_new</span><span class="o">.</span><span class="n">num_sites</span><span class="p">,</span> <span class="s2">&quot;.&quot;</span><span class="p">)</span>
    <span class="n">sample_loc</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">random</span><span class="o">.</span><span class="n">choice</span><span class="p">(</span><span class="n">mts_new</span><span class="o">.</span><span class="n">sites</span><span class="p">(),</span> <span class="n">size</span><span class="o">=</span><span class="p">(</span><span class="n">mts_new</span><span class="o">.</span><span class="n">num_sites</span><span class="o">-</span><span class="n">num_loc</span><span class="p">),</span> <span class="n">replace</span><span class="o">=</span><span class="kc">False</span><span class="p">)</span>
    <span class="k">for</span> <span class="n">v</span> <span class="ow">in</span> <span class="n">sample_loc</span><span class="p">:</span>
        <span class="n">sites_to_discard</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">v</span><span class="o">.</span><span class="n">id</span><span class="p">)</span>
    <span class="n">mts_new</span> <span class="o">=</span> <span class="n">mts_new</span><span class="o">.</span><span class="n">delete_sites</span><span class="p">(</span><span class="n">sites_to_discard</span><span class="p">)</span>
    <span class="nb">print</span><span class="p">(</span><span class="s2">&quot;-- Nombre de variants conservés: &quot;</span><span class="p">,</span> <span class="n">mts_new</span><span class="o">.</span><span class="n">num_sites</span><span class="p">)</span>
    <span class="k">return</span> <span class="n">mts_new</span>

<span class="n">chromosomeSize</span> <span class="o">=</span> <span class="mf">2e09</span> <span class="c1"># Rappel de la taille de génome simulé, 2.0 Gb.</span>
<span class="n">mts1</span> <span class="o">=</span> <span class="n">removeMultiAllelic_global</span><span class="p">(</span><span class="n">mts</span><span class="p">)</span> <span class="c1"># Retrait des sites variables multi-alléliques.</span>
<span class="n">mts1</span> <span class="o">=</span> <span class="n">removeRareVariants_global</span><span class="p">(</span><span class="n">mts1</span><span class="p">,</span> <span class="mf">0.005</span><span class="p">)</span> <span class="c1"># Retrait des sites très peu variables. A user avec précautions.</span>
<span class="n">mts1</span> <span class="o">=</span> <span class="n">randomSitesSampler</span><span class="p">(</span><span class="n">mts1</span><span class="p">,</span> <span class="mi">30000</span><span class="p">,</span> <span class="n">chromosomeSize</span><span class="p">)</span> <span class="c1"># Sélection aléatoire de 30000 loci le long du génome.</span>
<span class="nb">print</span><span class="p">(</span><span class="n">mts1</span><span class="p">)</span>

<span class="n">mts1</span><span class="o">.</span><span class="n">dump</span><span class="p">(</span><span class="s2">&quot;POPSIZE_pyslim_Cohort</span><span class="si">%s</span><span class="s2">_</span><span class="si">%s</span><span class="s2">_mts1.trees&quot;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">))</span>

<span class="n">indivlist</span> <span class="o">=</span> <span class="p">[]</span>
<span class="n">indivnames</span> <span class="o">=</span> <span class="p">[]</span> 
<span class="k">for</span> <span class="n">i</span> <span class="ow">in</span> <span class="n">mts1</span><span class="o">.</span><span class="n">individuals</span><span class="p">():</span>
    <span class="k">if</span> <span class="n">mts1</span><span class="o">.</span><span class="n">node</span><span class="p">(</span><span class="n">i</span><span class="o">.</span><span class="n">nodes</span><span class="p">[</span><span class="mi">0</span><span class="p">])</span><span class="o">.</span><span class="n">is_sample</span><span class="p">():</span>
       <span class="n">indivlist</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">i</span><span class="o">.</span><span class="n">id</span><span class="p">)</span>
       <span class="k">assert</span> <span class="n">mts1</span><span class="o">.</span><span class="n">node</span><span class="p">(</span><span class="n">i</span><span class="o">.</span><span class="n">nodes</span><span class="p">[</span><span class="mi">1</span><span class="p">])</span><span class="o">.</span><span class="n">is_sample</span><span class="p">()</span>
       <span class="n">pid0</span> <span class="o">=</span> <span class="n">i</span><span class="o">.</span><span class="n">metadata</span><span class="p">[</span><span class="s1">&#39;pedigree_id&#39;</span><span class="p">]</span>
       <span class="n">indivnames</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">samples</span><span class="o">.</span><span class="n">ID</span><span class="p">[</span><span class="n">samples</span><span class="o">.</span><span class="n">pid</span> <span class="o">==</span> <span class="nb">str</span><span class="p">(</span><span class="n">pid0</span><span class="p">)]</span><span class="o">.</span><span class="n">item</span><span class="p">())</span>
<span class="k">with</span> <span class="nb">open</span><span class="p">(</span><span class="s2">&quot;POPSIZE_pyslim_output_Cohort</span><span class="si">%s</span><span class="s2">_</span><span class="si">%s</span><span class="s2">.vcf&quot;</span> <span class="o">%</span> <span class="p">(</span><span class="n">str1</span><span class="p">,</span> <span class="n">str2</span><span class="p">),</span> <span class="s2">&quot;w&quot;</span><span class="p">)</span> <span class="k">as</span> <span class="n">vcffile</span><span class="p">:</span>
    <span class="n">mts1</span><span class="o">.</span><span class="n">write_vcf</span><span class="p">(</span><span class="n">vcffile</span><span class="p">,</span> <span class="n">individuals</span><span class="o">=</span><span class="n">indivlist</span><span class="p">,</span> <span class="n">individual_names</span><span class="o">=</span><span class="n">indivnames</span><span class="p">)</span>
    
<span class="c1"># Fin du script Python.   </span>
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<pre>5098387  sites restants après le retrait des loci à plus de 2 allèles.
2348675  sites restants après le retrait des loci de MAF &lt;  0.005 .
-- Nombre de variants conservés:  30000
╔══════════════════════════╗
║TreeSequence              ║
╠═══════════════╤══════════╣
║Trees          │   4827996║
╟───────────────┼──────────╢
║Sequence Length│2000000000║
╟───────────────┼──────────╢
║Time Units     │     ticks║
╟───────────────┼──────────╢
║Sample Nodes   │     29712║
╟───────────────┼──────────╢
║Total Size     │ 695.7 MiB║
╚═══════════════╧══════════╝
╔═══════════╤════════╤═════════╤════════════╗
║Table      │Rows    │Size     │Has Metadata║
╠═══════════╪════════╪═════════╪════════════╣
║Edges      │16636023│507.7 MiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Individuals│   14978│  1.4 MiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Migrations │       0│  8 Bytes│          No║
╟───────────┼────────┼─────────┼────────────╢
║Mutations  │   30000│  1.1 MiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Nodes      │ 2132052│ 57.9 MiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Populations│       3│  2.3 KiB│         Yes║
╟───────────┼────────┼─────────┼────────────╢
║Provenances│       8│ 17.5 KiB│          No║
╟───────────┼────────┼─────────┼────────────╢
║Sites      │   30000│732.4 KiB│          No║
╚═══════════╧════════╧═════════╧════════════╝

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<p>Notre procédure de simulation est à présent terminée. Pour consulter les procédures de post-traitement des données, consulter le document R Markdown <code>POPSIZE_Script_PostProcessing_exempleFR</code> fourni en Annexe du rapport scientifique final du projet POPSIZE, ainsi que les sections I.3.3, OP.I.4 et OP.I.5 du même rapport.</p>
<p>Fin de document Jupyter Notebook.</p>

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