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Potential enhancements #302

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ph09 opened this issue Aug 17, 2023 · 0 comments
Open

Potential enhancements #302

ph09 opened this issue Aug 17, 2023 · 0 comments

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@ph09
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ph09 commented Aug 17, 2023

  1. ability to import and consider GAM data as it relates to the HAL graph (a la minigraph-cactus alignments)
  2. the importance of unified masking in annotation. For example, we find identical orthologous sequence is often differentially annotated across samples, if done independently, due to actual and artificial vagaries in repetitive content. See https://www.nature.com/articles/s41467-022-35621-7 and https://github.com/brianabernathy/kmer_masked_annotation.
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