Monkeypox_Final.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "id": "a164648d",
   "metadata": {},
   "source": [
    "# Monkeypox KG"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "00f91898",
   "metadata": {},
   "source": [
    "# Package installation is required only once"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "2ed7b171",
   "metadata": {},
   "outputs": [],
   "source": [
    "#pip install -r packages.txt"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "id": "8c141672",
   "metadata": {},
   "outputs": [],
   "source": [
    "import pybel\n",
    "from pybel.dsl import Protein\n",
    "from pybel.dsl import Abundance\n",
    "from pybel.dsl import Pathology\n",
    "from pybel.dsl import BiologicalProcess\n",
    "from pybel.dsl import Population\n",
    "from pybel.dsl import Gene\n",
    "from pybel.dsl import MicroRna\n",
    "from pybel.dsl import Rna\n",
    "from pybel.dsl import Fragment\n",
    "from tqdm import tqdm\n",
    "import pandas as pd\n",
    "from pybel.dsl import *\n",
    "import chembl_webresource_client\n",
    "import openpyxl\n",
    "import networkx as nx\n",
    "from pybel.io.jupyter import to_jupyter\n",
    "import matplotlib.pyplot as plt\n",
    "from chembl_webresource_client.new_client import new_client\n",
    "import pubchempy\n",
    "import pickle\n",
    "import re\n",
    "from mpox import *\n",
    "import pubchempy as pcp\n",
    "import urllib\n",
    "from urllib.parse import urlparse\n",
    "import io\n",
    "import seaborn as sns\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "d30c1b4b",
   "metadata": {},
   "source": [
    "# Drugs against monkeypox from https://www.jglobalbiosecurity.com/articles/10.31646/gbio.12 + chembl database"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "id": "7e1bdfe6",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['CHEMBL1257073',\n",
       " 'CHEMBL1257073',\n",
       " 'CHEMBL1257073',\n",
       " 'CHEMBL221054',\n",
       " 'CHEMBL375768',\n",
       " 'CHEMBL220150',\n",
       " 'CHEMBL1257073',\n",
       " 'CHEMBL220610',\n",
       " 'CHEMBL1257073']"
      ]
     },
     "execution_count": 17,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mpox_chembl = pd.read_csv('data/normalized_data/chembl_mpox_actives.csv',sep=';',usecols=['Molecule ChEMBL ID','pChEMBL Value'])\n",
    "mpox_chembl= mpox_chembl[mpox_chembl['pChEMBL Value'] >= 6]\n",
    "mpox_chembl = list(mpox_chembl['Molecule ChEMBL ID'])\n",
    "mpox_chembl"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "bd8476c4",
   "metadata": {},
   "source": [
    "# Reading file from pubchem for monkeypox \n",
    "# https://pubchem.ncbi.nlm.nih.gov/taxonomy/10244"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "id": "6246d121",
   "metadata": {},
   "outputs": [],
   "source": [
    "\n",
    "mpox_pchem = pd.read_csv('data/normalized_data/TaxID_10244_bioactivity.csv')\n",
    "mpox_pchem = mpox_pchem['cid']\n",
    "mpox_pchem = list(set(mpox_pchem))\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "id": "c52a2e08",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Pubchem: 134406 Converted to: CHEMBL321500\n",
      "Pubchem: 44420748 Converted to: CHEMBL375768\n",
      "Pubchem: 101879053 Converted to: CHEMBL3357216\n",
      "Pubchem: 101879054 Converted to: CHEMBL3357215\n",
      "Pubchem: 16124688 Converted to: CHEMBL1257073\n",
      "Pubchem: 11243799 Converted to: CHEMBL220150\n",
      "Pubchem: 155545375 Converted to: CHEMBL4565849\n",
      "Pubchem: 11773602 Converted to: CHEMBL220610\n",
      "Pubchem: 73124 Converted to: CHEMBL494759\n",
      "Pubchem: 37542 Converted to: CHEMBL1643\n",
      "Pubchem: 44341289 Converted to: CHEMBL114867\n",
      "Pubchem: 44341811 Converted to: CHEMBL113930\n",
      "Pubchem: 44341812 Converted to: CHEMBL326139\n",
      "Pubchem: 118895042 Converted to: CHEMBL3753637\n",
      "Pubchem: 118895044 Converted to: CHEMBL3753489\n",
      "Pubchem: 60613 Converted to: CHEMBL152\n",
      "Pubchem: 11301322 Converted to: CHEMBL220098\n",
      "Pubchem: 189926 Converted to: CHEMBL112159\n",
      "Pubchem: 5271015 Converted to: CHEMBL360506\n",
      "Pubchem: 11452011 Converted to: CHEMBL219691\n",
      "Pubchem: 11463022 Converted to: CHEMBL221054\n",
      "Pubchem: 155521397 Converted to: CHEMBL4449833\n",
      "Pubchem: 45111031 Converted to: CHEMBL3290663\n",
      "Pubchem: 122873 Converted to: CHEMBL392630\n"
     ]
    }
   ],
   "source": [
    "pchem2chembl_list = cid2chembl(mpox_pchem)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "id": "ab0eefa9",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'CHEMBL1257073',\n",
       " 'CHEMBL220150',\n",
       " 'CHEMBL220610',\n",
       " 'CHEMBL221054',\n",
       " 'CHEMBL375768'}"
      ]
     },
     "execution_count": 20,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "z = set(mpox_chembl).intersection(pchem2chembl_list)\n",
    "z"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "id": "ce595d49",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "33"
      ]
     },
     "execution_count": 21,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "chemblid = mpox_chembl+pchem2chembl_list\n",
    "len(chemblid)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "id": "e38c0240",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "24"
      ]
     },
     "execution_count": 22,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "chemblid = set(chemblid)\n",
    "chemblid = list(chemblid)\n",
    "len(chemblid)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "id": "6d509845",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[{'mechanism_of_action': 'Envelope phospholipase F13 (p37) inhibitor', 'target_chembl_id': 'CHEMBL4296170'}]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[{'mechanism_of_action': 'Human herpesvirus 1 DNA polymerase inhibitor', 'target_chembl_id': 'CHEMBL1872'}]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[{'mechanism_of_action': \"Inosine-5'-monophosphate dehydrogenase 1 inhibitor\", 'target_chembl_id': 'CHEMBL1822'}, {'mechanism_of_action': 'Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor', 'target_chembl_id': 'CHEMBL5375'}, {'mechanism_of_action': 'RNA inhibitor', 'target_chembl_id': 'CHEMBL2363073'}]\n"
     ]
    }
   ],
   "source": [
    "chembl2mech = RetMech(chemblid)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "id": "47177306",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[{'mesh_heading': 'Virus Diseases'}, {'mesh_heading': 'Smallpox'}]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[{'mesh_heading': 'Virus Diseases'}, {'mesh_heading': 'Infections'}, {'mesh_heading': 'Kidney Diseases'}, {'mesh_heading': 'Sarcoma'}, '...(remaining elements truncated)...']\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[]\n",
      "[{'mesh_heading': 'Leukemia, Myeloid, Acute'}, {'mesh_heading': 'Hepatitis C, Chronic'}, {'mesh_heading': 'Hepatitis C'}, {'mesh_heading': 'Hepatitis B, Chronic'}, '...(remaining elements truncated)...']\n"
     ]
    }
   ],
   "source": [
    "chembl2dis = RetDrugInd(chemblid)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "id": "60b7c623",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Returns a dictionary\n",
    "def RetAct(chemblIds,j):\n",
    "    GetAct = new_client.activity\n",
    "    ActList = []\n",
    "    #for i in range(len(chemblIds)):\n",
    "    #print(chemblIds[0])\n",
    "    for i in range(len(chemblIds)):\n",
    "        filtered_list=['assay_chembl_id','assay_type','pchembl_value','target_chembl_id','target_organism','bao_label','target_type']\n",
    "        acts = GetAct.filter(molecule_chembl_id=chemblIds[i],pchembl_value__isnull=False,assay_type_iregex='(B|F)',target_organism='Homo sapiens').only(filtered_list)\n",
    "        #acts = GetAct.filter(molecule_chembl_id=chemblIds[i],pchembl_value__isnull=False,target_organism='Homo sapiens').only(filtered_list)\n",
    "        #acts = GetAct.filter(molecule_chembl_id=chemblIds[i],pchembl_value__isnull=False)\n",
    "        j=j+1\n",
    "\n",
    "        #acts = [d for d in acts if d.get('target_organism') == 'Homo sapiens']\n",
    "        #acts = [d for d in acts if d.get('bao_label') == 'single protein format']\n",
    "        #acts = [d for d in acts if d.get('type') in ['Ki', 'IC50']]\n",
    "        acts = [d for d in acts if float(d.get('pchembl_value')) >= 6]\n",
    "        print(j)\n",
    "        #print(len(acts))\n",
    "        #acts = acts[:5]\n",
    "        print(acts)\n",
    "        ActList.append(list(acts))\n",
    "    #print(ActList)\n",
    "    named_ActList = dict(zip(chemblIds,ActList))\n",
    "    named_ActList = {k: v for k, v in named_ActList.items() if v}\n",
    "    return(named_ActList)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 37,
   "id": "2bea413b",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "1\n",
      "[]\n",
      "2\n",
      "[{'assay_chembl_id': 'CHEMBL3294635', 'assay_type': 'B', 'bao_label': 'single protein format', 'pchembl_value': '7.62', 'target_chembl_id': 'CHEMBL2664', 'target_organism': 'Homo sapiens', 'type': 'IC50', 'value': '24.0'}, {'assay_chembl_id': 'CHEMBL3294636', 'assay_type': 'B', 'bao_label': 'cell-based format', 'pchembl_value': '8.03', 'target_chembl_id': 'CHEMBL2664', 'target_organism': 'Homo sapiens', 'type': 'IC50', 'value': '9.4'}]\n",
      "3\n",
      "[]\n",
      "4\n",
      "[]\n",
      "5\n",
      "[]\n",
      "6\n",
      "[]\n",
      "7\n",
      "[]\n",
      "8\n",
      "[]\n",
      "9\n",
      "[]\n",
      "10\n",
      "[]\n",
      "11\n",
      "[]\n",
      "12\n",
      "[]\n",
      "13\n",
      "[]\n",
      "14\n",
      "[]\n",
      "15\n",
      "[{'assay_chembl_id': 'CHEMBL3757541', 'assay_type': 'B', 'bao_label': 'single protein format', 'pchembl_value': '8.49', 'target_chembl_id': 'CHEMBL3751646', 'target_organism': 'Homo sapiens', 'type': 'IC50', 'value': '3.2'}]\n",
      "16\n",
      "[]\n",
      "17\n",
      "[]\n",
      "18\n",
      "[{'assay_chembl_id': 'CHEMBL746888', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '6.30', 'target_chembl_id': 'CHEMBL614200', 'target_organism': 'Homo sapiens', 'type': 'IC50', 'value': '0.5'}, {'assay_chembl_id': 'CHEMBL689980', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '6.22', 'target_chembl_id': 'CHEMBL613888', 'target_organism': 'Homo sapiens', 'type': 'EC50', 'value': '0.6'}, {'assay_chembl_id': 'CHEMBL689981', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '6.00', 'target_chembl_id': 'CHEMBL613888', 'target_organism': 'Homo sapiens', 'type': 'EC50', 'value': '1.0'}, {'assay_chembl_id': 'CHEMBL689978', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '6.80', 'target_chembl_id': 'CHEMBL613888', 'target_organism': 'Homo sapiens', 'type': 'EC50', 'value': '0.16'}, {'assay_chembl_id': 'CHEMBL689979', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '6.30', 'target_chembl_id': 'CHEMBL613888', 'target_organism': 'Homo sapiens', 'type': 'EC50', 'value': '0.5'}, {'assay_chembl_id': 'CHEMBL691435', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '6.24', 'target_chembl_id': 'CHEMBL613888', 'target_organism': 'Homo sapiens', 'type': 'EC50', 'value': '0.57'}, {'assay_chembl_id': 'CHEMBL838065', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '6.22', 'target_chembl_id': 'CHEMBL613888', 'target_organism': 'Homo sapiens', 'type': 'EC50', 'value': '0.6'}, {'assay_chembl_id': 'CHEMBL838053', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '6.00', 'target_chembl_id': 'CHEMBL613888', 'target_organism': 'Homo sapiens', 'type': 'EC50', 'value': '1.0'}]\n",
      "19\n",
      "[]\n",
      "20\n",
      "[{'assay_chembl_id': 'CHEMBL800629', 'assay_type': 'B', 'bao_label': 'single protein format', 'pchembl_value': '6.55', 'target_chembl_id': 'CHEMBL2664', 'target_organism': 'Homo sapiens', 'type': 'IC50', 'value': '0.28'}]\n",
      "21\n",
      "[]\n",
      "22\n",
      "[]\n",
      "23\n",
      "[]\n",
      "24\n",
      "[{'assay_chembl_id': 'CHEMBL674318', 'assay_type': 'F', 'bao_label': 'cell-based format', 'pchembl_value': '8.30', 'target_chembl_id': 'CHEMBL614149', 'target_organism': 'Homo sapiens', 'type': 'EC50', 'value': '0.005'}, {'assay_chembl_id': 'CHEMBL1614544', 'assay_type': 'F', 'bao_label': 'assay format', 'pchembl_value': '8.40', 'target_chembl_id': 'CHEMBL1293235', 'target_organism': 'Homo sapiens', 'type': 'Potency', 'value': '0.004'}, {'assay_chembl_id': 'CHEMBL1614108', 'assay_type': 'A', 'bao_label': 'single protein format', 'pchembl_value': '6.10', 'target_chembl_id': 'CHEMBL340', 'target_organism': 'Homo sapiens', 'type': 'Potency', 'value': '0.7943'}, {'assay_chembl_id': 'CHEMBL1613886', 'assay_type': 'A', 'bao_label': 'single protein format', 'pchembl_value': '6.10', 'target_chembl_id': 'CHEMBL340', 'target_organism': 'Homo sapiens', 'type': 'Potency', 'value': '0.7943'}]\n"
     ]
    }
   ],
   "source": [
    "#chemblid = ['CHEMBL3294635','CHEMBL221054']\n",
    "chembl2act = RetAct(chemblid,0)\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "id": "760230b5",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['CHEMBL614200',\n",
       " 'CHEMBL614149',\n",
       " 'CHEMBL1872',\n",
       " 'CHEMBL613888',\n",
       " 'CHEMBL1822',\n",
       " 'CHEMBL3988586',\n",
       " 'CHEMBL340',\n",
       " 'CHEMBL2664',\n",
       " 'CHEMBL4296170',\n",
       " 'CHEMBL1293235',\n",
       " 'CHEMBL2363073',\n",
       " 'CHEMBL5375',\n",
       " 'CHEMBL3751646']"
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "prtn_as_chembl = Ret_chembl_protein(chembl2act) + Ret_chembl_protein(chembl2mech)\n",
    "prtn_as_chembl = set(prtn_as_chembl)\n",
    "prtn_as_chembl = list(prtn_as_chembl)\n",
    "prtn_as_chembl"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "id": "73cb4e9e",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "old 9\n",
      "newLen 7\n",
      "2\n"
     ]
    }
   ],
   "source": [
    "chembl2uprot = chembl2uniprot(prtn_as_chembl,0)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "id": "48d0f511",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'CHEMBL1822': [{'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73817',\n",
       "   'xref_name': 'Purine ribonucleoside monophosphate biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20839'},\n",
       "  {'component_synonym': 'IMPDH1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3988586': [{'accession': 'P06856'},\n",
       "  {'component_synonym': 'POL', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL340': [{'xref_id': 'R-HSA-211981',\n",
       "   'xref_name': 'Xenobiotics.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5423646',\n",
       "   'xref_name': 'Aflatoxin activation and detoxification.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027307',\n",
       "   'xref_name': 'Biosynthesis of maresin-like SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08684'},\n",
       "  {'component_synonym': 'CYP3A4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2664': [{'xref_id': 'R-HSA-156581',\n",
       "   'xref_name': 'Methylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1614635',\n",
       "   'xref_name': 'Sulfur amino acid metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2408508',\n",
       "   'xref_name': 'Metabolism of ingested SeMet, Sec, MeSec into H2Se.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5578997',\n",
       "   'xref_name': 'Defective AHCY causes HMAHCHD.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P23526'},\n",
       "  {'component_synonym': 'AHCY', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293235': [{'xref_id': 'R-HSA-1221632',\n",
       "   'xref_name': 'Meiotic synapsis. [P02545-2]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2980766',\n",
       "   'xref_name': 'Nuclear Envelope Breakdown.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2995383',\n",
       "   'xref_name': 'Initiation of Nuclear Envelope (NE) Reformation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-352238',\n",
       "   'xref_name': 'Breakdown of the nuclear lamina. [P02545-1]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381038',\n",
       "   'xref_name': 'XBP1(S) activates chaperone genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4419969',\n",
       "   'xref_name': 'Depolymerisation of the Nuclear Lamina.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802952',\n",
       "   'xref_name': 'Signaling by BRAF and RAF fusions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8862803',\n",
       "   'xref_name': \"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models. [P02545-1]\",\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P02545'},\n",
       "  {'component_synonym': 'LMNA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5375': [{'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q8JXU8'},\n",
       "  {'component_synonym': 'NS5B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3751646': [{'xref_id': 'R-HSA-112043',\n",
       "   'xref_name': 'PLC beta mediated events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1489509',\n",
       "   'xref_name': 'DAG and IP3 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2029485',\n",
       "   'xref_name': 'Role of phospholipids in phagocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2871809',\n",
       "   'xref_name': 'FCERI mediated Ca+2 mobilization.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-422356',\n",
       "   'xref_name': 'Regulation of insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5218921',\n",
       "   'xref_name': 'VEGFR2 mediated cell proliferation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5578775',\n",
       "   'xref_name': 'Ion homeostasis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5607763',\n",
       "   'xref_name': 'CLEC7A (Dectin-1) induces NFAT activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9664323',\n",
       "   'xref_name': 'FCGR3A-mediated IL10 synthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983695',\n",
       "   'xref_name': 'Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O43865'},\n",
       "  {'component_synonym': 'AHCYL1', 'syn_type': 'GENE_SYMBOL'}]}"
      ]
     },
     "execution_count": 12,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "chembl2uprot"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "id": "992bc3b9",
   "metadata": {},
   "outputs": [],
   "source": [
    "#update chembl protein nodes with gene symbol\n",
    "#use previously created variable that stores activity info\n",
    "chembl2act = chembl2gene2path(chembl2uprot,chembl2act)\n",
    "chembl2mech = chembl2gene2path(chembl2uprot,chembl2mech)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "bff2e2f5",
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": 111,
   "id": "2bd41ffc",
   "metadata": {},
   "outputs": [],
   "source": [
    "mpox_graph = pybel.BELGraph(name='Monkeypox Graph')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 112,
   "id": "3b1cfaa4",
   "metadata": {
    "scrolled": false
   },
   "outputs": [],
   "source": [
    "mpox_graph = chem2moa_rel_2(chembl2mech,'HGNC',mpox_graph)\n",
    "mpox_graph = chem2dis_rel(chembl2dis,mpox_graph)\n",
    "mpox_graph = chem2act_rel_2(chembl2act,'HGNC',mpox_graph)\n",
    "mpox_graph = chem2gene2path_rel(chembl2uprot,'HGNC',mpox_graph)\n",
    "#to_jupyter(mpox_graph)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "5a73cd11",
   "metadata": {},
   "outputs": [],
   "source": [
    "# filename = ('data/normalized_data/monkeypox_pickle2')\n",
    "# outfile = open(filename,'wb')\n",
    "# pickle.dump(mpox_graph,outfile)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "d57b51dc",
   "metadata": {},
   "outputs": [],
   "source": [
    "#import monkey pox graph\n",
    "infile = open('data/normalized_data/monkeypox_pickle2','rb')\n",
    "mpox_graph = pickle.load(infile)\n",
    "infile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 113,
   "id": "b7813a04",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "            <h2>Metadata</h2>\n",
       "            <table>\n",
       "<tbody>\n",
       "<tr><td>Name   </td><td>Monkeypox Graph</td></tr>\n",
       "<tr><td>Version</td><td>               </td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Statistics</h2>\n",
       "            <table>\n",
       "<tbody>\n",
       "<tr><td>Nodes          </td><td style=\"text-align: right;\">103     </td></tr>\n",
       "<tr><td>Namespaces     </td><td style=\"text-align: right;\">  6     </td></tr>\n",
       "<tr><td>Edges          </td><td style=\"text-align: right;\">218     </td></tr>\n",
       "<tr><td>Annotations    </td><td style=\"text-align: right;\">  0     </td></tr>\n",
       "<tr><td>Citations      </td><td style=\"text-align: right;\">  1     </td></tr>\n",
       "<tr><td>Authors        </td><td style=\"text-align: right;\">  0     </td></tr>\n",
       "<tr><td>Components     </td><td style=\"text-align: right;\">  3     </td></tr>\n",
       "<tr><td>Warnings       </td><td style=\"text-align: right;\">  0     </td></tr>\n",
       "<tr><td>Network Density</td><td style=\"text-align: right;\">  0.0208</td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Nodes</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Type             </th><th style=\"text-align: right;\">  Count</th><th>Example                                          </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>Pathology        </td><td style=\"text-align: right;\">     36</td><td>path(Disease:&quot;Kidney Diseases&quot;)                  </td></tr>\n",
       "<tr><td>BiologicalProcess</td><td style=\"text-align: right;\">     34</td><td>bp(Reactome:&quot;Biosynthesis of maresin-like SPMs.&quot;)</td></tr>\n",
       "<tr><td>Abundance        </td><td style=\"text-align: right;\">     20</td><td>a(ChEMBLAssay:CHEMBL3294635)                     </td></tr>\n",
       "<tr><td>Protein          </td><td style=\"text-align: right;\">     13</td><td>p(HGNC:CHEMBL613888)                             </td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Namespaces</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Prefix     </th><th>Name                            </th><th style=\"text-align: right;\">  Count</th><th>Example                                                     </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>Disease    </td><td>                                </td><td style=\"text-align: right;\">     36</td><td>path(Disease:Thrombocytopenia)                              </td></tr>\n",
       "<tr><td>Reactome   </td><td>Reactome                        </td><td style=\"text-align: right;\">     28</td><td>bp(Reactome:&quot;Meiotic synapsis. [P02545-2]&quot;)                 </td></tr>\n",
       "<tr><td>HGNC       </td><td>HUGO Gene Nomenclature Committee</td><td style=\"text-align: right;\">     13</td><td>p(HGNC:CHEMBL4296170)                                       </td></tr>\n",
       "<tr><td>ChEMBLAssay</td><td>                                </td><td style=\"text-align: right;\">     13</td><td>a(ChEMBLAssay:CHEMBL689979)                                 </td></tr>\n",
       "<tr><td>ChEMBL     </td><td>ChEMBL                          </td><td style=\"text-align: right;\">      7</td><td>a(ChEMBL:CHEMBL3753637)                                     </td></tr>\n",
       "<tr><td>MOA        </td><td>                                </td><td style=\"text-align: right;\">      6</td><td>bp(MOA:&quot;Inosine-5&#x27;-monophosphate dehydrogenase 1 inhibitor&quot;)</td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Edges</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Edge Type                              </th><th style=\"text-align: right;\">  Count</th><th>Example                                                                               </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>Pathology association Abundance        </td><td style=\"text-align: right;\">     42</td><td>path(Disease:&quot;Diabetes Mellitus, Type 1&quot;) association a(ChEMBL:CHEMBL1643)            </td></tr>\n",
       "<tr><td>Protein association BiologicalProcess  </td><td style=\"text-align: right;\">     29</td><td>p(HGNC:AHCYL1) association bp(Reactome:&quot;Role of phospholipids in phagocytosis.&quot;)      </td></tr>\n",
       "<tr><td>Protein association Abundance          </td><td style=\"text-align: right;\">     19</td><td>p(HGNC:AHCY) association a(ChEMBLAssay:CHEMBL3294636)                                 </td></tr>\n",
       "<tr><td>BiologicalProcess association Abundance</td><td style=\"text-align: right;\">      6</td><td>bp(MOA:&quot;Human herpesvirus 1 DNA polymerase inhibitor&quot;) association a(ChEMBL:CHEMBL152)</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/plain": [
       "<pybel.struct.graph.SummarizeDispatch at 0x198025c16f0>"
      ]
     },
     "execution_count": 113,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mpox_graph.summarize"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "id": "0472efdc",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['P20839', 'P06856', 'P08684', 'P23526', 'P02545', 'Q8JXU8', 'O43865']"
      ]
     },
     "execution_count": 18,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Fetch all proteins from the graph\n",
    "chemblProt = Ret_uprotid(chembl2uprot)\n",
    "chemblProt\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "3d1d07c3",
   "metadata": {},
   "source": [
    "# Working with monkeypox proteins from uniprot"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 32,
   "id": "7388ac2f",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "C:\\Users\\reagon.karki\\Anaconda3\\envs\\bycovid_new\\lib\\site-packages\\openpyxl\\styles\\stylesheet.py:226: UserWarning: Workbook contains no default style, apply openpyxl's default\n",
      "  warn(\"Workbook contains no default style, apply openpyxl's default\")\n"
     ]
    },
    {
     "data": {
      "text/plain": [
       "['Q8V4Y0',\n",
       " 'Q8V4S4',\n",
       " 'Q8V571',\n",
       " 'P04363',\n",
       " 'Q8V4V3',\n",
       " 'Q8V4U9',\n",
       " 'Q8V4T3',\n",
       " 'Q8V518',\n",
       " 'Q8V4V4',\n",
       " 'Q8V4T7',\n",
       " 'Q8V566']"
      ]
     },
     "execution_count": 32,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mpox_prot_df = pd.read_excel('data/normalized_data/uniprot-taxonomy Monkeypox+virus+[10244] -filtered-reviewed yes.xlsx')\n",
    "mpox_prot= list(mpox_prot_df['Entry'])\n",
    "mpox_prot"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "94e19f34",
   "metadata": {},
   "source": [
    "# Genes from Malacards"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "id": "c7fac4b6",
   "metadata": {},
   "outputs": [],
   "source": [
    "mpox_genes_df = pd.read_excel('data/normalized_data/malacardsGenes.xlsx')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "id": "e6bb6787",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "13"
      ]
     },
     "execution_count": 20,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mpox_genes = list(mpox_genes_df['Entry'])\n",
    "len(mpox_genes)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "id": "ab671397",
   "metadata": {},
   "outputs": [],
   "source": [
    "uprots = mpox_genes+chemblProt"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "id": "ff5140f3",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['P0C0L4',\n",
       " 'P0C0L5',\n",
       " 'Q9Y258',\n",
       " 'Q07444',\n",
       " 'P01730',\n",
       " 'P01732',\n",
       " 'Q8NH81',\n",
       " 'P26718',\n",
       " 'P08174',\n",
       " 'P00387',\n",
       " 'P15529',\n",
       " 'Q14653',\n",
       " 'P01562',\n",
       " 'P20839',\n",
       " 'P06856',\n",
       " 'P08684',\n",
       " 'P23526',\n",
       " 'P02545',\n",
       " 'Q8JXU8',\n",
       " 'O43865']"
      ]
     },
     "execution_count": 22,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "uprots"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "id": "4e754a4a",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "https://www.uniprot.org/uniprot/P0C0L4.txt\n",
      "{'Gene': 'C4A'}\n",
      "https://www.uniprot.org/uniprot/P0C0L5.txt\n",
      "{'Gene': 'C4B'}\n",
      "https://www.uniprot.org/uniprot/Q9Y258.txt\n",
      "https://www.uniprot.org/uniprot/Q07444.txt\n",
      "{'Gene': 'KLRC3'}\n",
      "https://www.uniprot.org/uniprot/P01730.txt\n",
      "{'Gene': 'CD4'}\n",
      "https://www.uniprot.org/uniprot/P01732.txt\n",
      "{'Gene': 'CD8A'}\n",
      "https://www.uniprot.org/uniprot/Q8NH81.txt\n",
      "{'Gene': 'OR10G6'}\n",
      "https://www.uniprot.org/uniprot/P26718.txt\n",
      "{'Gene': 'KLRK1'}\n",
      "https://www.uniprot.org/uniprot/P08174.txt\n",
      "{'Gene': 'CD55'}\n",
      "https://www.uniprot.org/uniprot/P00387.txt\n",
      "https://www.uniprot.org/uniprot/P15529.txt\n",
      "{'Gene': 'CD46'}\n",
      "https://www.uniprot.org/uniprot/Q14653.txt\n",
      "https://www.uniprot.org/uniprot/P01562.txt\n",
      "{'Gene': 'IFNA1'}\n",
      "https://www.uniprot.org/uniprot/P20839.txt\n",
      "https://www.uniprot.org/uniprot/P06856.txt\n",
      "{'Gene': 'POL'}\n",
      "https://www.uniprot.org/uniprot/P08684.txt\n",
      "https://www.uniprot.org/uniprot/P23526.txt\n",
      "{'Gene': 'AHCY'}\n",
      "https://www.uniprot.org/uniprot/P02545.txt\n",
      "{'Gene': 'LMNA'}\n",
      "https://www.uniprot.org/uniprot/Q8JXU8.txt\n",
      "https://www.uniprot.org/uniprot/O43865.txt\n"
     ]
    }
   ],
   "source": [
    "uprots_ext = ExtractFromUniProt(uprots)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "id": "c6f7d424",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "https://www.uniprot.org/uniprot/Q8V4Y0.txt\n",
      "https://www.uniprot.org/uniprot/Q8V4S4.txt\n",
      "https://www.uniprot.org/uniprot/Q8V571.txt\n",
      "{'Gene': 'p28'}\n",
      "https://www.uniprot.org/uniprot/P04363.txt\n",
      "{'Gene': 'TK'}\n",
      "https://www.uniprot.org/uniprot/Q8V4V3.txt\n",
      "{'Gene': 'RPO132'}\n",
      "https://www.uniprot.org/uniprot/Q8V4U9.txt\n",
      "https://www.uniprot.org/uniprot/Q8V4T3.txt\n",
      "https://www.uniprot.org/uniprot/Q8V518.txt\n",
      "https://www.uniprot.org/uniprot/Q8V4V4.txt\n",
      "{'Gene': 'VITF3L'}\n",
      "https://www.uniprot.org/uniprot/Q8V4T7.txt\n",
      "https://www.uniprot.org/uniprot/Q8V566.txt\n"
     ]
    }
   ],
   "source": [
    "mpox_prot_ext = ExtractFromUniProt(mpox_prot)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "id": "2eb172a9",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'Q8V4Y0': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {'carbonate dehydratase activity': 'GO:0004089',\n",
       "   'zinc ion binding': 'GO:0008270'},\n",
       "  'BioProcess': {'viral entry into host cell': 'GO:0046718',\n",
       "   'virion attachment to host cell': 'GO:0019062'},\n",
       "  'Gene': {}},\n",
       " 'Q8V4S4': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {\"2',3'-cyclic GMP-AMP binding\": 'GO:0061507',\n",
       "   'nuclease activity': 'GO:0004518'},\n",
       "  'BioProcess': {'suppression by virus of host innate immune response': 'GO:0039503'},\n",
       "  'Gene': 'B4R'},\n",
       " 'Q8V571': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {'acid-amino acid ligase activity': 'GO:0016881',\n",
       "   'metal ion binding': 'GO:0046872',\n",
       "   'transferase activity': 'GO:0016740'},\n",
       "  'BioProcess': {'modulation by virus of host apoptotic process': 'GO:0039526',\n",
       "   'modulation by virus of host protein ubiquitination': 'GO:0039648'},\n",
       "  'Gene': 'p28'},\n",
       " 'P04363': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {'ATP binding': 'GO:0005524',\n",
       "   'metal ion binding': 'GO:0046872',\n",
       "   'thymidine kinase activity': 'GO:0004797'},\n",
       "  'BioProcess': {'DNA biosynthetic process': 'GO:0071897'},\n",
       "  'Gene': 'TK'},\n",
       " 'Q8V4V3': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {'DNA binding': 'GO:0003677',\n",
       "   \"DNA-directed 5'-3' RNA polymerase activity\": 'GO:0003899',\n",
       "   'metal ion binding': 'GO:0046872',\n",
       "   'ribonucleoside binding': 'GO:0032549'},\n",
       "  'BioProcess': {'transcription, DNA-templated': 'GO:0006351'},\n",
       "  'Gene': 'RPO132'},\n",
       " 'Q8V4U9': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {},\n",
       "  'BioProcess': {'membrane fusion involved in viral entry into host cell': 'GO:0039663',\n",
       "   'viral entry into host cell': 'GO:0046718'},\n",
       "  'Gene': {}},\n",
       " 'Q8V4T3': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {'metal ion binding': 'GO:0046872'},\n",
       "  'BioProcess': {'superoxide metabolic process': 'GO:0006801'},\n",
       "  'Gene': {}},\n",
       " 'Q8V518': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {'DNA binding': 'GO:0003677'},\n",
       "  'BioProcess': {},\n",
       "  'Gene': {}},\n",
       " 'Q8V4V4': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {},\n",
       "  'BioProcess': {},\n",
       "  'Gene': 'VITF3L'},\n",
       " 'Q8V4T7': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {'actin binding': 'GO:0003779'},\n",
       "  'BioProcess': {},\n",
       "  'Gene': {}},\n",
       " 'Q8V566': {'Disease': {},\n",
       "  'Reactome': {},\n",
       "  'Function': {},\n",
       "  'BioProcess': {'viral process': 'GO:0016032'},\n",
       "  'Gene': {}}}"
      ]
     },
     "execution_count": 34,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mpox_prot_ext"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 30,
   "id": "fd9c0889",
   "metadata": {},
   "outputs": [],
   "source": [
    "\n",
    "# function to create relationships for dict created using ExtractFromUniProt\n",
    "def uniprot_rel(named_uprotList,org,itmpGraph):\n",
    "    for item in named_uprotList:\n",
    "        # print(named_uprotList[item]['Function'].keys())\n",
    "        fun = list(named_uprotList[item]['Function'].keys())\n",
    "        bp = list(named_uprotList[item]['BioProcess'].keys())\n",
    "        for f in fun:\n",
    "            if str(named_uprotList[item]['Gene']) != 'nan' and not isinstance(named_uprotList[item]['Gene'], dict):\n",
    "                itmpGraph.add_association(Protein(namespace=org, name=named_uprotList[item]['Gene']),\n",
    "                                          BiologicalProcess(namespace='GOMF', name=f),\n",
    "                                          citation='UniProt database', evidence='UniProt query')\n",
    "            else:\n",
    "                itmpGraph.add_association(Protein(namespace=org, name=item),\n",
    "                                          BiologicalProcess(namespace='GOMF', name=f),\n",
    "                                          citation='UniProt database', evidence='UniProt query')\n",
    "\n",
    "        for b in bp:\n",
    "            if str(named_uprotList[item]['Gene']) != 'nan' and not isinstance(named_uprotList[item]['Gene'], dict):\n",
    "                itmpGraph.add_association(Protein(namespace=org, name=named_uprotList[item]['Gene']),\n",
    "                                          BiologicalProcess(namespace='GOBP', name=b),\n",
    "                                          citation='UniProt database', evidence='UniProt query')\n",
    "            else:\n",
    "                itmpGraph.add_association(Protein(namespace=org, name=item),\n",
    "                                          BiologicalProcess(namespace='GOBP', name=b),\n",
    "                                          citation='UniProt database', evidence='UniProt query')\n",
    "\n",
    "    return (itmpGraph)\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 114,
   "id": "090ac595",
   "metadata": {},
   "outputs": [],
   "source": [
    "mpox_graph = uniprot_rel(uprots_ext,'HGNC',mpox_graph)\n",
    "mpox_graph = uniprot_rel(mpox_prot_ext,'MPXV',mpox_graph)\n",
    "#to_jupyter(mpox_graph)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "id": "92755a69",
   "metadata": {},
   "outputs": [],
   "source": [
    "# filename = 'data/normalized_data/monkeypox_pickle_25thJuly'\n",
    "# outfile = open(filename,'wb')\n",
    "# pickle.dump(mpox_graph,outfile)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 70,
   "id": "7c5d3a05",
   "metadata": {},
   "outputs": [],
   "source": [
    "#import monkey pox graph\n",
    "infile = open('data/normalized_data/monkeypox_pickle_25thjuly','rb')\n",
    "mpox_graph = pickle.load(infile)\n",
    "infile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "2aeb9c6a",
   "metadata": {},
   "outputs": [],
   "source": [
    "to_jupyter(mpox_graph)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "id": "d67f059b",
   "metadata": {},
   "outputs": [],
   "source": [
    "def _get_target_data(protein_list: list, organism: str):\n",
    "    \"\"\"Get chemical for target data from ChEMBL\"\"\"\n",
    "    df_data = []\n",
    "\n",
    "    target = new_client.target\n",
    "    activity = new_client.activity\n",
    "\n",
    "    for protein in protein_list:\n",
    "        if pd.isna(protein):\n",
    "            continue\n",
    "        try:\n",
    "            prot_data = [target.search(protein)[0]]\n",
    "\n",
    "            # Search for protein with same synonym\n",
    "            if prot_data == [None]:\n",
    "                prot_data = target.filter(\n",
    "                    target_synonym__icontains=protein, target_organism__istartswith=organism\n",
    "                ).only(['target_chembl_id', 'target_pref_name', 'molecule_chembl_id', 'molecule_pref_name'])\n",
    "        except HttpBadRequest:\n",
    "            print(f'Cannot search for {protein} due to chembl error')\n",
    "            continue\n",
    "\n",
    "        # No results found\n",
    "        if not prot_data:\n",
    "            continue\n",
    "\n",
    "        for prot in tqdm(prot_data, f'Analying data for {protein}'):\n",
    "            # Absence of chembl id\n",
    "            if not prot['target_chembl_id']:\n",
    "                continue\n",
    "\n",
    "            prot_activity_data = activity.filter(\n",
    "                target_chembl_id=prot['target_chembl_id'],\n",
    "                assay_type_iregex='(B|F)',\n",
    "            ).only([\n",
    "                'pchembl_value', 'molecule_chembl_id', 'activity_id', 'target_pref_name', 'molecule_pref_name'\n",
    "            ])\n",
    "\n",
    "            if len(prot_activity_data) < 1:\n",
    "                continue\n",
    "\n",
    "            for i in prot_activity_data:\n",
    "                tmp = {}\n",
    "\n",
    "                if i['pchembl_value'] is None:\n",
    "                    continue\n",
    "\n",
    "                pchembl_val = i['pchembl_value']\n",
    "\n",
    "                if float(pchembl_val) < 6:\n",
    "                    tmp['activity'] = 'inhibitor'\n",
    "                else:\n",
    "                    tmp['activity'] = 'activator'\n",
    "\n",
    "                tmp['protein_symbol'] = protein\n",
    "                tmp['protein_name'] = i['target_pref_name']\n",
    "                tmp['aid'] = str(i['activity_id'])\n",
    "                tmp['chembl_id'] = i['molecule_chembl_id']\n",
    "                tmp['compound_name'] = i['molecule_pref_name'].capitalize() if i['molecule_pref_name'] else ''\n",
    "                df_data.append(tmp)\n",
    "\n",
    "    # Merge duplicated protein-chemical entries into one\n",
    "    df = pd.DataFrame()\n",
    "\n",
    "    for idx, row in tqdm(enumerate(df_data), total=len(df_data), desc='Preparing data'):\n",
    "        if idx == 0:\n",
    "            df = df.append(row, ignore_index=True)\n",
    "        else:\n",
    "            _in_df = df.loc[\n",
    "                (df['protein_symbol'] == row['protein_symbol']) & (df['chembl_id'] == row['chembl_id'])\n",
    "            ]\n",
    "\n",
    "            if _in_df.empty:\n",
    "                df = df.append(row, ignore_index=True)\n",
    "            else:\n",
    "                row_index = _in_df.index\n",
    "\n",
    "                # Check existing citations\n",
    "                existing_assays = set(df.loc[row_index, 'aid'].values[0].split(' | '))\n",
    "                old_count = len(existing_assays)\n",
    "                existing_assays.add(row['aid'])\n",
    "                new_count = len(existing_assays)\n",
    "\n",
    "                # Check if new citation added, if yes - add respective data\n",
    "                if old_count < new_count:\n",
    "                    df.loc[row_index, 'aid'] = ' | '.join(existing_assays)\n",
    "    df = df[['activity', 'protein_symbol', 'protein_name', 'aid', 'chembl_id', 'compound_name']]\n",
    "    return df\n",
    "\n",
    "def target_list_to_chemical(\n",
    "    proteins: list,\n",
    "    organism: str = 'Homo sapiens',\n",
    "    output_dir: str = ''\n",
    ") -> None:\n",
    "    \"\"\"Extract chemical information on list of targets\n",
    "    Usage:\n",
    "    >> target_list_to_chemical(proteins=['RIPK'])\n",
    "    \"\"\"\n",
    "\n",
    "    df = _get_target_data(protein_list=proteins, organism=organism)\n",
    "    #os.makedirs(output_dir, exist_ok=True)\n",
    "    #df.to_csv(os.path.join(output_dir, 'chemical_annotated.csv'), sep='\\t', index=False)\n",
    "    return(df)\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "ee3badd9",
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "id": "7fb99090",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Analying data for Q14653: 100%|██████████| 1/1 [00:00<00:00, 143.42it/s]\n",
      "Analying data for P00387: 100%|██████████| 1/1 [00:00<00:00, 125.41it/s]\n",
      "Analying data for P01730: 100%|██████████| 1/1 [00:00<00:00, 111.44it/s]\n",
      "Analying data for Q05823: 100%|██████████| 1/1 [00:00<00:00, 83.61it/s]\n",
      "Analying data for P01562: 100%|██████████| 1/1 [00:00<00:00, 250.80it/s]\n",
      "Analying data for P07315: 100%|██████████| 1/1 [00:00<00:00, 125.42it/s]\n",
      "Analying data for P23919: 100%|██████████| 1/1 [00:00<00:00, 83.56it/s]\n",
      "Analying data for P01574: 100%|██████████| 1/1 [00:00<00:00, 250.66it/s]\n",
      "Analying data for P20839: 100%|██████████| 1/1 [00:00<00:00, 66.89it/s]\n",
      "Analying data for P23526: 100%|██████████| 1/1 [00:00<00:00, 22.80it/s]\n",
      "Analying data for O43865: 100%|██████████| 1/1 [00:00<00:00, 200.53it/s]\n",
      "Analying data for Q8JXU8:   0%|          | 0/1 [01:07<?, ?it/s]\n"
     ]
    },
    {
     "ename": "HttpApplicationError",
     "evalue": "Error for url https://www.ebi.ac.uk/chembl/api/data/activity.json, server response: <!doctype html>\r\n<!-- paulirish.com/2008/conditional-stylesheets-vs-css-hacks-answer-neither/ -->\r\n<!--[if lt IE 7]> <html class=\"no-js ie6 oldie\" lang=\"en\"> <![endif]-->\r\n<!--[if IE 7]>    <html class=\"no-js ie7 oldie\" lang=\"en\"> <![endif]-->\r\n<!--[if IE 8]>    <html class=\"no-js ie8 oldie\" lang=\"en\"> <![endif]-->\r\n<!-- Consider adding an manifest.appcache: h5bp.com/d/Offline -->\r\n<!--[if gt IE 8]><!--> <html class=\"no-js\" lang=\"en\"> <!--<![endif]-->\r\n<head>\r\n    <meta charset=\"utf-8\">\r\n\r\n    <!-- Use the .htaccess and remove these lines to avoid edge case issues.\r\n More info: h5bp.com/b/378 -->\r\n    <!-- <meta http-equiv=\"X-UA-Compatible\" content=\"IE=edge,chrome=1\"> --> <!-- Not yet implemented -->\r\n\r\n    <title>Server error &lt; EMBL-EBI</title>\r\n    <meta name=\"description\" content=\"EMBL-EBI\"><!-- Describe what this page is about -->\r\n    <meta name=\"keywords\" content=\"bioinformatics, europe, institute\"><!-- A few keywords that relate to the content of THIS PAGE (not the whol project) -->\r\n    <meta name=\"author\" content=\"EMBL-EBI\"><!-- Your [project-name] here -->\r\n\r\n    <!-- Mobile viewport optimized: j.mp/bplateviewport -->\r\n    <meta name=\"viewport\" content=\"width=device-width,initial-scale=1\">\r\n\r\n    <!-- Place favicon.ico and apple-touch-icon.png in the root directory: mathiasbynens.be/notes/touch-icons -->\r\n\r\n    <!-- CSS: implied media=all -->\r\n    <!-- CSS concatenated and minified via ant build script-->\r\n    <link rel=\"stylesheet\" href=\"//www.ebi.ac.uk/web_guidelines/css/compliance/develop/boilerplate-style.css\">\r\n    <link rel=\"stylesheet\" href=\"//www.ebi.ac.uk/web_guidelines/css/compliance/develop/ebi-global.css\" type=\"text/css\" media=\"screen\">\r\n    <link rel=\"stylesheet\" href=\"//www.ebi.ac.uk/web_guidelines/css/compliance/develop/ebi-visual.css\" type=\"text/css\" media=\"screen\">\r\n    <link rel=\"stylesheet\" href=\"//www.ebi.ac.uk/web_guidelines/css/compliance/develop/984-24-col-fluid.css\" type=\"text/css\" media=\"screen\">\r\n\r\n    <!-- you can replace this with [projectname]-colours.css. 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We're very sorry.</p>\r\n<p>Please try again but if it keeps happening, you can <a fix=\"h-\" href=\"//www.ebi.ac.uk/support\">contact us</a> and we will try to help you.</p>\r\n</div>\r\n      </div>\r\n</div>\r\n  </div>\r\n\r\n  \r\n  \r\n</div>\r\n  </div>\r\n\r\n\r\n    \r\n  <div class=\"content\">\r\n    <form id=\"ebi_search\" action=\"/ebisearch/search.ebi\">\r\n  <fieldset><legend><span>Explore the EBI:</span></legend>\r\n    <input id=\"query\" title=\"EB-eye Search\" tabindex=\"1\" type=\"text\" name=\"query\" value=\"\" size=\"35\" maxlength=\"2048\" style=\"width: 80%\" /><input id=\"search_submit\" class=\"submit\" tabindex=\"2\" type=\"submit\" value=\"Search\" name=\"submit\" /><input id=\"allebi\" type=\"hidden\" name=\"db\" value=\"allebi\" checked=\"checked\" /><input type=\"hidden\" name=\"requestFrom\" value=\"ebi_error\" /><div>\r\n     <p id=\"example\">Examples: <a href=\"/ebisearch/search.ebi?db=allebi&amp;requestFrom=ebi_error&amp;query=blast\">blast</a>, <a href=\"/ebisearch/search.ebi?db=allebi&amp;query=keratin&amp;requestFrom=ebi_error\">keratin</a>, <a href=\"/ebisearch/search.ebi?db=allebi&amp;query=bfl1&amp;requestFrom=ebi_error\">bfl1</a>...</p>\r\n    </div>\r\n  </fieldset></form>  </div>\r\n\r\n\t\t\t\t\t\t\t\t\t\t\r\n      \t\t\t\t\t\t\t\t\t\t\r\n\t\t</section>    </section>\r\n\r\n        <!-- End example layout containers -->\r\n\r\n</div>\r\n\r\n<footer>\r\n\r\n    <!-- Optional local footer (insert citation / project-specific copyright / etc here -->\r\n        <!--\r\n        <div id=\"local-footer\" class=\"grid_24 clearfix\">\r\n      <p>How to reference this page: ...</p>\r\n    </div>\r\n        -->\r\n        <!-- End optional local footer -->\r\n        \r\n    <div id=\"global-footer\" class=\"grid_24\">\r\n\r\n        <nav id=\"global-nav-expanded\">\r\n\r\n            <div class=\"grid_4 alpha\">\r\n                <h3 class=\"embl-ebi\"><a href=\"//www.ebi.ac.uk/\" title=\"EMBL-EBI\">EMBL-EBI</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4\">\r\n                <h3 class=\"services\"><a href=\"//www.ebi.ac.uk/services\">Services</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4\">\r\n                <h3 class=\"research\"><a href=\"//www.ebi.ac.uk/research\">Research</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4\">\r\n                <h3 class=\"training\"><a href=\"//www.ebi.ac.uk/training\">Training</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4\">\r\n                <h3 class=\"industry\"><a href=\"//www.ebi.ac.uk/industry\">Industry</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4 omega\">\r\n                <h3 class=\"about\"><a href=\"//www.ebi.ac.uk/about\">About us</a></h3>\r\n            </div>\r\n\r\n        </nav>\r\n\r\n        <section id=\"ebi-footer-meta\">\r\n            <p class=\"address\">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK &nbsp; &nbsp; +44 (0)1223 49 44 44</p>\r\n            <p class=\"legal\">Copyright &copy; EMBL-EBI 2013 | EBI is an Outstation of the <a href=\"http://www.embl.org\">European Molecular Biology Laboratory</a> | <a href=\"/about/privacy\">Privacy</a> | <a href=\"/about/cookies\">Cookies</a> | <a href=\"/about/terms-of-use\">Terms of use</a></p>\r\n        </section>\r\n\r\n    </div>\r\n        \r\n</footer>\r\n</div> <!--! end of #wrapper -->\r\n\r\n\r\n<!-- JavaScript at the bottom for fast page loading -->\r\n\r\n<!-- Grab Google CDN's jQuery, with a protocol relative URL; fall back to local if offline -->\r\n<!--\r\n<script src=\"//ajax.googleapis.com/ajax/libs/jquery/1.6.2/jquery.min.js\"></script>\r\n<script>window.jQuery || document.write('<script src=\"../js/libs/jquery-1.6.2.min.js\"><\\/script>')</script>\r\n-->\r\n\r\n\r\n<!-- Your custom JavaScript file can go here... change names accordingly -->\r\n<script defer=\"defer\" src=\"//www.ebi.ac.uk/web_guidelines/js/cookiebanner.js\"></script>\r\n<script defer=\"defer\" src=\"//www.ebi.ac.uk/web_guidelines/js/foot.js\"></script>\r\n<!-- end scripts-->\r\n\r\n<!-- Google Analytics details... -->\r\n<!-- Change UA-XXXXX-X to be your site's ID -->\r\n<!--\r\n<script>\r\n  window._gaq = [['_setAccount','UAXXXXXXXX1'],['_trackPageview'],['_trackPageLoadTime']];\r\n  Modernizr.load({\r\n    load: ('https:' == location.protocol ? '//ssl' : '//www') + '.google-analytics.com/ga.js'\r\n  });\r\n</script>\r\n-->\r\n\r\n\r\n<!-- Prompt IE 6 users to install Chrome Frame. Remove this if you want to support IE 6.\r\nchromium.org/developers/how-tos/chrome-frame-getting-started -->\r\n<!--[if lt IE 7 ]>\r\n<script src=\"//ajax.googleapis.com/ajax/libs/chrome-frame/1.0.3/CFInstall.min.js\"></script>\r\n<script>window.attachEvent('onload',function(){CFInstall.check({mode:'overlay'})})</script>\r\n<![endif]-->\r\n\r\n\r\n</body>\r\n</html>\r\n",
     "output_type": "error",
     "traceback": [
      "\u001b[1;31m---------------------------------------------------------------------------\u001b[0m",
      "\u001b[1;31mHttpApplicationError\u001b[0m                      Traceback (most recent call last)",
      "Input \u001b[1;32mIn [16]\u001b[0m, in \u001b[0;36m<cell line: 1>\u001b[1;34m()\u001b[0m\n\u001b[1;32m----> 1\u001b[0m uprot2chem \u001b[38;5;241m=\u001b[39m \u001b[43mtarget_list_to_chemical\u001b[49m\u001b[43m(\u001b[49m\u001b[43muprots\u001b[49m\u001b[43m)\u001b[49m\n",
      "Input \u001b[1;32mIn [15]\u001b[0m, in \u001b[0;36mtarget_list_to_chemical\u001b[1;34m(proteins, organism, output_dir)\u001b[0m\n\u001b[0;32m     90\u001b[0m \u001b[38;5;28;01mdef\u001b[39;00m \u001b[38;5;21mtarget_list_to_chemical\u001b[39m(\n\u001b[0;32m     91\u001b[0m     proteins: \u001b[38;5;28mlist\u001b[39m,\n\u001b[0;32m     92\u001b[0m     organism: \u001b[38;5;28mstr\u001b[39m \u001b[38;5;241m=\u001b[39m \u001b[38;5;124m'\u001b[39m\u001b[38;5;124mHomo sapiens\u001b[39m\u001b[38;5;124m'\u001b[39m,\n\u001b[0;32m     93\u001b[0m     output_dir: \u001b[38;5;28mstr\u001b[39m \u001b[38;5;241m=\u001b[39m \u001b[38;5;124m'\u001b[39m\u001b[38;5;124m'\u001b[39m\n\u001b[0;32m     94\u001b[0m ) \u001b[38;5;241m-\u001b[39m\u001b[38;5;241m>\u001b[39m \u001b[38;5;28;01mNone\u001b[39;00m:\n\u001b[0;32m     95\u001b[0m     \u001b[38;5;124;03m\"\"\"Extract chemical information on list of targets\u001b[39;00m\n\u001b[0;32m     96\u001b[0m \u001b[38;5;124;03m    Usage:\u001b[39;00m\n\u001b[0;32m     97\u001b[0m \u001b[38;5;124;03m    >> target_list_to_chemical(proteins=['RIPK'])\u001b[39;00m\n\u001b[0;32m     98\u001b[0m \u001b[38;5;124;03m    \"\"\"\u001b[39;00m\n\u001b[1;32m--> 100\u001b[0m     df \u001b[38;5;241m=\u001b[39m \u001b[43m_get_target_data\u001b[49m\u001b[43m(\u001b[49m\u001b[43mprotein_list\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mproteins\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43morganism\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43morganism\u001b[49m\u001b[43m)\u001b[49m\n\u001b[0;32m    101\u001b[0m     \u001b[38;5;66;03m#os.makedirs(output_dir, exist_ok=True)\u001b[39;00m\n\u001b[0;32m    102\u001b[0m     \u001b[38;5;66;03m#df.to_csv(os.path.join(output_dir, 'chemical_annotated.csv'), sep='\\t', index=False)\u001b[39;00m\n\u001b[0;32m    103\u001b[0m     \u001b[38;5;28;01mreturn\u001b[39;00m(df)\n",
      "Input \u001b[1;32mIn [15]\u001b[0m, in \u001b[0;36m_get_target_data\u001b[1;34m(protein_list, organism)\u001b[0m\n\u001b[0;32m     39\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mlen\u001b[39m(prot_activity_data) \u001b[38;5;241m<\u001b[39m \u001b[38;5;241m1\u001b[39m:\n\u001b[0;32m     40\u001b[0m     \u001b[38;5;28;01mcontinue\u001b[39;00m\n\u001b[1;32m---> 42\u001b[0m \u001b[38;5;28;01mfor\u001b[39;00m i \u001b[38;5;129;01min\u001b[39;00m prot_activity_data:\n\u001b[0;32m     43\u001b[0m     tmp \u001b[38;5;241m=\u001b[39m {}\n\u001b[0;32m     45\u001b[0m     \u001b[38;5;28;01mif\u001b[39;00m i[\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mpchembl_value\u001b[39m\u001b[38;5;124m'\u001b[39m] \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m:\n",
      "File \u001b[1;32m~\\Anaconda3\\envs\\bycovid_new\\lib\\site-packages\\chembl_webresource_client\\query_set.py:127\u001b[0m, in \u001b[0;36mQuerySet.__next__\u001b[1;34m(self)\u001b[0m\n\u001b[0;32m    126\u001b[0m \u001b[38;5;28;01mdef\u001b[39;00m \u001b[38;5;21m__next__\u001b[39m(\u001b[38;5;28mself\u001b[39m):\n\u001b[1;32m--> 127\u001b[0m     \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mnext\u001b[49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\n",
      "File \u001b[1;32m~\\Anaconda3\\envs\\bycovid_new\\lib\\site-packages\\chembl_webresource_client\\query_set.py:115\u001b[0m, in \u001b[0;36mQuerySet.next\u001b[1;34m(self)\u001b[0m\n\u001b[0;32m    113\u001b[0m     \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mchunk \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mquery\u001b[38;5;241m.\u001b[39mget_page()\n\u001b[0;32m    114\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mchunk \u001b[38;5;129;01mor\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mcurrent_index \u001b[38;5;241m>\u001b[39m\u001b[38;5;241m=\u001b[39m \u001b[38;5;28mlen\u001b[39m(\u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mchunk):\n\u001b[1;32m--> 115\u001b[0m     \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mchunk \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mquery\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mnext_page\u001b[49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\n\u001b[0;32m    116\u001b[0m     \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mchunk:\n\u001b[0;32m    117\u001b[0m         \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mStopIteration\u001b[39;00m\n",
      "File \u001b[1;32m~\\Anaconda3\\envs\\bycovid_new\\lib\\site-packages\\chembl_webresource_client\\url_query.py:434\u001b[0m, in \u001b[0;36mUrlQuery.next_page\u001b[1;34m(self)\u001b[0m\n\u001b[0;32m    432\u001b[0m start \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mstart\n\u001b[0;32m    433\u001b[0m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mcurrent_index \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mint\u001b[39m(start \u001b[38;5;241m+\u001b[39m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mlimit \u001b[38;5;241m*\u001b[39m (\u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mcurrent_page \u001b[38;5;241m+\u001b[39m \u001b[38;5;241m1\u001b[39m))\n\u001b[1;32m--> 434\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mget_page\u001b[49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\n",
      "File \u001b[1;32m~\\Anaconda3\\envs\\bycovid_new\\lib\\site-packages\\chembl_webresource_client\\url_query.py:394\u001b[0m, in \u001b[0;36mUrlQuery.get_page\u001b[1;34m(self)\u001b[0m\n\u001b[0;32m    392\u001b[0m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mlogger\u001b[38;5;241m.\u001b[39minfo(\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mFrom cache: \u001b[39m\u001b[38;5;132;01m{0}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;241m.\u001b[39mformat(res\u001b[38;5;241m.\u001b[39mfrom_cache \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mhasattr\u001b[39m(res, \u001b[38;5;124m'\u001b[39m\u001b[38;5;124mfrom_cache\u001b[39m\u001b[38;5;124m'\u001b[39m) \u001b[38;5;28;01melse\u001b[39;00m \u001b[38;5;28;01mFalse\u001b[39;00m))\n\u001b[0;32m    393\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m res\u001b[38;5;241m.\u001b[39mok:\n\u001b[1;32m--> 394\u001b[0m     \u001b[43mhandle_http_error\u001b[49m\u001b[43m(\u001b[49m\u001b[43mres\u001b[49m\u001b[43m)\u001b[49m\n\u001b[0;32m    395\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mfrmt \u001b[38;5;241m==\u001b[39m \u001b[38;5;124m'\u001b[39m\u001b[38;5;124mjson\u001b[39m\u001b[38;5;124m'\u001b[39m:\n\u001b[0;32m    396\u001b[0m     json_data \u001b[38;5;241m=\u001b[39m res\u001b[38;5;241m.\u001b[39mjson()\n",
      "File \u001b[1;32m~\\Anaconda3\\envs\\bycovid_new\\lib\\site-packages\\chembl_webresource_client\\http_errors.py:113\u001b[0m, in \u001b[0;36mhandle_http_error\u001b[1;34m(request)\u001b[0m\n\u001b[0;32m    111\u001b[0m exception_class \u001b[38;5;241m=\u001b[39m status_to_exception\u001b[38;5;241m.\u001b[39mget(request\u001b[38;5;241m.\u001b[39mstatus_code, BaseHttpException)\n\u001b[0;32m    112\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m request\u001b[38;5;241m.\u001b[39mtext:\n\u001b[1;32m--> 113\u001b[0m     \u001b[38;5;28;01mraise\u001b[39;00m exception_class(request\u001b[38;5;241m.\u001b[39murl, request\u001b[38;5;241m.\u001b[39mtext)\n\u001b[0;32m    114\u001b[0m \u001b[38;5;28;01mraise\u001b[39;00m exception_class(request\u001b[38;5;241m.\u001b[39murl, request\u001b[38;5;241m.\u001b[39mcontent)\n",
      "\u001b[1;31mHttpApplicationError\u001b[0m: Error for url https://www.ebi.ac.uk/chembl/api/data/activity.json, server response: <!doctype html>\r\n<!-- paulirish.com/2008/conditional-stylesheets-vs-css-hacks-answer-neither/ -->\r\n<!--[if lt IE 7]> <html class=\"no-js ie6 oldie\" lang=\"en\"> <![endif]-->\r\n<!--[if IE 7]>    <html class=\"no-js ie7 oldie\" lang=\"en\"> <![endif]-->\r\n<!--[if IE 8]>    <html class=\"no-js ie8 oldie\" lang=\"en\"> <![endif]-->\r\n<!-- Consider adding an manifest.appcache: h5bp.com/d/Offline -->\r\n<!--[if gt IE 8]><!--> <html class=\"no-js\" lang=\"en\"> <!--<![endif]-->\r\n<head>\r\n    <meta charset=\"utf-8\">\r\n\r\n    <!-- Use the .htaccess and remove these lines to avoid edge case issues.\r\n More info: h5bp.com/b/378 -->\r\n    <!-- <meta http-equiv=\"X-UA-Compatible\" content=\"IE=edge,chrome=1\"> --> <!-- Not yet implemented -->\r\n\r\n    <title>Server error &lt; EMBL-EBI</title>\r\n    <meta name=\"description\" content=\"EMBL-EBI\"><!-- Describe what this page is about -->\r\n    <meta name=\"keywords\" content=\"bioinformatics, europe, institute\"><!-- A few keywords that relate to the content of THIS PAGE (not the whol project) -->\r\n    <meta name=\"author\" content=\"EMBL-EBI\"><!-- Your [project-name] here -->\r\n\r\n    <!-- Mobile viewport optimized: j.mp/bplateviewport -->\r\n    <meta name=\"viewport\" content=\"width=device-width,initial-scale=1\">\r\n\r\n    <!-- Place favicon.ico and apple-touch-icon.png in the root directory: mathiasbynens.be/notes/touch-icons -->\r\n\r\n    <!-- CSS: implied media=all -->\r\n    <!-- CSS concatenated and minified via ant build script-->\r\n    <link rel=\"stylesheet\" href=\"//www.ebi.ac.uk/web_guidelines/css/compliance/develop/boilerplate-style.css\">\r\n    <link rel=\"stylesheet\" href=\"//www.ebi.ac.uk/web_guidelines/css/compliance/develop/ebi-global.css\" type=\"text/css\" media=\"screen\">\r\n    <link rel=\"stylesheet\" href=\"//www.ebi.ac.uk/web_guidelines/css/compliance/develop/ebi-visual.css\" type=\"text/css\" media=\"screen\">\r\n    <link rel=\"stylesheet\" href=\"//www.ebi.ac.uk/web_guidelines/css/compliance/develop/984-24-col-fluid.css\" type=\"text/css\" media=\"screen\">\r\n\r\n    <!-- you can replace this with [projectname]-colours.css. 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We're very sorry.</p>\r\n<p>Please try again but if it keeps happening, you can <a fix=\"h-\" href=\"//www.ebi.ac.uk/support\">contact us</a> and we will try to help you.</p>\r\n</div>\r\n      </div>\r\n</div>\r\n  </div>\r\n\r\n  \r\n  \r\n</div>\r\n  </div>\r\n\r\n\r\n    \r\n  <div class=\"content\">\r\n    <form id=\"ebi_search\" action=\"/ebisearch/search.ebi\">\r\n  <fieldset><legend><span>Explore the EBI:</span></legend>\r\n    <input id=\"query\" title=\"EB-eye Search\" tabindex=\"1\" type=\"text\" name=\"query\" value=\"\" size=\"35\" maxlength=\"2048\" style=\"width: 80%\" /><input id=\"search_submit\" class=\"submit\" tabindex=\"2\" type=\"submit\" value=\"Search\" name=\"submit\" /><input id=\"allebi\" type=\"hidden\" name=\"db\" value=\"allebi\" checked=\"checked\" /><input type=\"hidden\" name=\"requestFrom\" value=\"ebi_error\" /><div>\r\n     <p id=\"example\">Examples: <a href=\"/ebisearch/search.ebi?db=allebi&amp;requestFrom=ebi_error&amp;query=blast\">blast</a>, <a href=\"/ebisearch/search.ebi?db=allebi&amp;query=keratin&amp;requestFrom=ebi_error\">keratin</a>, <a href=\"/ebisearch/search.ebi?db=allebi&amp;query=bfl1&amp;requestFrom=ebi_error\">bfl1</a>...</p>\r\n    </div>\r\n  </fieldset></form>  </div>\r\n\r\n\t\t\t\t\t\t\t\t\t\t\r\n      \t\t\t\t\t\t\t\t\t\t\r\n\t\t</section>    </section>\r\n\r\n        <!-- End example layout containers -->\r\n\r\n</div>\r\n\r\n<footer>\r\n\r\n    <!-- Optional local footer (insert citation / project-specific copyright / etc here -->\r\n        <!--\r\n        <div id=\"local-footer\" class=\"grid_24 clearfix\">\r\n      <p>How to reference this page: ...</p>\r\n    </div>\r\n        -->\r\n        <!-- End optional local footer -->\r\n        \r\n    <div id=\"global-footer\" class=\"grid_24\">\r\n\r\n        <nav id=\"global-nav-expanded\">\r\n\r\n            <div class=\"grid_4 alpha\">\r\n                <h3 class=\"embl-ebi\"><a href=\"//www.ebi.ac.uk/\" title=\"EMBL-EBI\">EMBL-EBI</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4\">\r\n                <h3 class=\"services\"><a href=\"//www.ebi.ac.uk/services\">Services</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4\">\r\n                <h3 class=\"research\"><a href=\"//www.ebi.ac.uk/research\">Research</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4\">\r\n                <h3 class=\"training\"><a href=\"//www.ebi.ac.uk/training\">Training</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4\">\r\n                <h3 class=\"industry\"><a href=\"//www.ebi.ac.uk/industry\">Industry</a></h3>\r\n            </div>\r\n\r\n            <div class=\"grid_4 omega\">\r\n                <h3 class=\"about\"><a href=\"//www.ebi.ac.uk/about\">About us</a></h3>\r\n            </div>\r\n\r\n        </nav>\r\n\r\n        <section id=\"ebi-footer-meta\">\r\n            <p class=\"address\">EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK &nbsp; &nbsp; +44 (0)1223 49 44 44</p>\r\n            <p class=\"legal\">Copyright &copy; EMBL-EBI 2013 | EBI is an Outstation of the <a href=\"http://www.embl.org\">European Molecular Biology Laboratory</a> | <a href=\"/about/privacy\">Privacy</a> | <a href=\"/about/cookies\">Cookies</a> | <a href=\"/about/terms-of-use\">Terms of use</a></p>\r\n        </section>\r\n\r\n    </div>\r\n        \r\n</footer>\r\n</div> <!--! end of #wrapper -->\r\n\r\n\r\n<!-- JavaScript at the bottom for fast page loading -->\r\n\r\n<!-- Grab Google CDN's jQuery, with a protocol relative URL; fall back to local if offline -->\r\n<!--\r\n<script src=\"//ajax.googleapis.com/ajax/libs/jquery/1.6.2/jquery.min.js\"></script>\r\n<script>window.jQuery || document.write('<script src=\"../js/libs/jquery-1.6.2.min.js\"><\\/script>')</script>\r\n-->\r\n\r\n\r\n<!-- Your custom JavaScript file can go here... change names accordingly -->\r\n<script defer=\"defer\" src=\"//www.ebi.ac.uk/web_guidelines/js/cookiebanner.js\"></script>\r\n<script defer=\"defer\" src=\"//www.ebi.ac.uk/web_guidelines/js/foot.js\"></script>\r\n<!-- end scripts-->\r\n\r\n<!-- Google Analytics details... -->\r\n<!-- Change UA-XXXXX-X to be your site's ID -->\r\n<!--\r\n<script>\r\n  window._gaq = [['_setAccount','UAXXXXXXXX1'],['_trackPageview'],['_trackPageLoadTime']];\r\n  Modernizr.load({\r\n    load: ('https:' == location.protocol ? '//ssl' : '//www') + '.google-analytics.com/ga.js'\r\n  });\r\n</script>\r\n-->\r\n\r\n\r\n<!-- Prompt IE 6 users to install Chrome Frame. Remove this if you want to support IE 6.\r\nchromium.org/developers/how-tos/chrome-frame-getting-started -->\r\n<!--[if lt IE 7 ]>\r\n<script src=\"//ajax.googleapis.com/ajax/libs/chrome-frame/1.0.3/CFInstall.min.js\"></script>\r\n<script>window.attachEvent('onload',function(){CFInstall.check({mode:'overlay'})})</script>\r\n<![endif]-->\r\n\r\n\r\n</body>\r\n</html>\r\n"
     ]
    }
   ],
   "source": [
    "uprot2chem = target_list_to_chemical(uprots)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "c4e28fe2",
   "metadata": {},
   "outputs": [],
   "source": [
    "uprot2chem"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "fa50a0d8",
   "metadata": {},
   "outputs": [],
   "source": [
    "# filename = 'data/normalized_data/uprot2chembl'\n",
    "# outfile = open(filename,'wb')\n",
    "# pickle.dump(uprot2chem,outfile)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "id": "59c68fa6",
   "metadata": {},
   "outputs": [],
   "source": [
    "infile = open('data/normalized_data/uprot2chembl','rb')\n",
    "uprot2chem = pickle.load(infile)\n",
    "infile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "id": "c91e637b",
   "metadata": {},
   "outputs": [],
   "source": [
    "uprot2chem.to_csv('data/normalized_data/uprot2chembl.csv',sep=',')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "id": "58cf982f",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'O43865',\n",
       " 'P00387',\n",
       " 'P01730',\n",
       " 'P02545',\n",
       " 'P06856',\n",
       " 'P08684',\n",
       " 'P20839',\n",
       " 'P23526',\n",
       " 'Q14653',\n",
       " 'Q8JXU8'}"
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "uprot2chem=set(uprot2chem['protein_symbol'])\n",
    "uprot2chem"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "id": "f9de9bf8",
   "metadata": {},
   "outputs": [],
   "source": [
    "uprots= ['Q8NH81',\n",
    " 'Q68D06',\n",
    " 'Q14653',\n",
    " 'Q8WVL7',\n",
    " 'Q9Y258',\n",
    " 'Q8IYM2',\n",
    " 'P01732',\n",
    " 'P00387',\n",
    " 'P0C0L4',\n",
    " 'P01730',\n",
    " 'Q05823',\n",
    " 'P0C0L5',\n",
    " 'P01562',\n",
    " 'P07315',\n",
    " 'P15529',\n",
    " 'P26718',\n",
    " 'P08174',\n",
    " 'P23919',\n",
    " 'P01574',\n",
    " 'P20839',\n",
    " 'P23526',\n",
    " 'O43865',\n",
    " 'Q8JXU8',\n",
    " 'P08684']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "id": "cd7a945c",
   "metadata": {},
   "outputs": [],
   "source": [
    "active = uprot2chem.loc[uprot2chem['activity'].str.contains('activator',na=False)]\n",
    "active = active.reset_index(drop=True)\n",
    "#active.to_csv('data/normalized_data/active_uprot2chem.csv',sep=',')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 40,
   "id": "8fd8a07d",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>activity</th>\n",
       "      <th>protein_symbol</th>\n",
       "      <th>protein_name</th>\n",
       "      <th>aid</th>\n",
       "      <th>chembl_id</th>\n",
       "      <th>compound_name</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>activator</td>\n",
       "      <td>P01730</td>\n",
       "      <td>T-cell surface antigen CD4</td>\n",
       "      <td>105411</td>\n",
       "      <td>CHEMBL506605</td>\n",
       "      <td>Isocomplestatin</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>activator</td>\n",
       "      <td>P01730</td>\n",
       "      <td>T-cell surface antigen CD4</td>\n",
       "      <td>106547</td>\n",
       "      <td>CHEMBL525803</td>\n",
       "      <td>Chloropeptin</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>activator</td>\n",
       "      <td>P01730</td>\n",
       "      <td>T-cell surface antigen CD4</td>\n",
       "      <td>106550</td>\n",
       "      <td>CHEMBL3143464</td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>activator</td>\n",
       "      <td>P01730</td>\n",
       "      <td>T-cell surface antigen CD4</td>\n",
       "      <td>20710180</td>\n",
       "      <td>CHEMBL1852155</td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>activator</td>\n",
       "      <td>P01730</td>\n",
       "      <td>T-cell surface antigen CD4</td>\n",
       "      <td>22435351</td>\n",
       "      <td>CHEMBL1819181</td>\n",
       "      <td>Cyclotriazadisulfonamide hydrochloride</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9031</th>\n",
       "      <td>activator</td>\n",
       "      <td>P08684</td>\n",
       "      <td>Cytochrome P450 3A4</td>\n",
       "      <td>22851099</td>\n",
       "      <td>CHEMBL4739976</td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9032</th>\n",
       "      <td>activator</td>\n",
       "      <td>P08684</td>\n",
       "      <td>Cytochrome P450 3A4</td>\n",
       "      <td>22851101</td>\n",
       "      <td>CHEMBL4760660</td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9033</th>\n",
       "      <td>activator</td>\n",
       "      <td>P08684</td>\n",
       "      <td>Cytochrome P450 3A4</td>\n",
       "      <td>22851104</td>\n",
       "      <td>CHEMBL4758649</td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9034</th>\n",
       "      <td>activator</td>\n",
       "      <td>P08684</td>\n",
       "      <td>Cytochrome P450 3A4</td>\n",
       "      <td>22851106</td>\n",
       "      <td>CHEMBL4788002</td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9035</th>\n",
       "      <td>activator</td>\n",
       "      <td>P08684</td>\n",
       "      <td>Cytochrome P450 3A4</td>\n",
       "      <td>22900688</td>\n",
       "      <td>CHEMBL4779873</td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>9036 rows × 6 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "       activity protein_symbol                protein_name       aid  \\\n",
       "0     activator         P01730  T-cell surface antigen CD4    105411   \n",
       "1     activator         P01730  T-cell surface antigen CD4    106547   \n",
       "2     activator         P01730  T-cell surface antigen CD4    106550   \n",
       "3     activator         P01730  T-cell surface antigen CD4  20710180   \n",
       "4     activator         P01730  T-cell surface antigen CD4  22435351   \n",
       "...         ...            ...                         ...       ...   \n",
       "9031  activator         P08684         Cytochrome P450 3A4  22851099   \n",
       "9032  activator         P08684         Cytochrome P450 3A4  22851101   \n",
       "9033  activator         P08684         Cytochrome P450 3A4  22851104   \n",
       "9034  activator         P08684         Cytochrome P450 3A4  22851106   \n",
       "9035  activator         P08684         Cytochrome P450 3A4  22900688   \n",
       "\n",
       "          chembl_id                           compound_name  \n",
       "0      CHEMBL506605                         Isocomplestatin  \n",
       "1      CHEMBL525803                            Chloropeptin  \n",
       "2     CHEMBL3143464                                          \n",
       "3     CHEMBL1852155                                          \n",
       "4     CHEMBL1819181  Cyclotriazadisulfonamide hydrochloride  \n",
       "...             ...                                     ...  \n",
       "9031  CHEMBL4739976                                          \n",
       "9032  CHEMBL4760660                                          \n",
       "9033  CHEMBL4758649                                          \n",
       "9034  CHEMBL4788002                                          \n",
       "9035  CHEMBL4779873                                          \n",
       "\n",
       "[9036 rows x 6 columns]"
      ]
     },
     "execution_count": 40,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "active"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 42,
   "id": "92efadb1",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "True"
      ]
     },
     "execution_count": 42,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "active['compound_name'][3] == ''"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "id": "a6cf1268",
   "metadata": {},
   "outputs": [],
   "source": [
    "active = active[active['compound_name'] != '']\n",
    "active = active.reset_index(drop=True)\n",
    "active.to_csv('data/normalized_data/active_uprot2chem.csv',sep=',')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 44,
   "id": "eb73f671",
   "metadata": {},
   "outputs": [],
   "source": [
    "chem = active['chembl_id']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "783d5001",
   "metadata": {},
   "outputs": [],
   "source": [
    "len(chem)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "d39dbf5b",
   "metadata": {},
   "outputs": [],
   "source": [
    "chem = ['CHEMBL506605',\n",
    " 'CHEMBL525803',\n",
    " 'CHEMBL3143464',\n",
    " 'CHEMBL3138360',\n",
    " 'CHEMBL3138345',\n",
    " 'CHEMBL3138187',\n",
    " 'CHEMBL3138374',\n",
    " 'CHEMBL3138095',\n",
    " 'CHEMBL3138378',\n",
    " 'CHEMBL3138119',\n",
    " 'CHEMBL231224',\n",
    " 'CHEMBL267655',\n",
    " 'CHEMBL388209',\n",
    " 'CHEMBL230799',\n",
    " 'CHEMBL267658',\n",
    " 'CHEMBL388208',\n",
    " 'CHEMBL267657',\n",
    " 'CHEMBL230798',\n",
    " 'CHEMBL388207',\n",
    " 'CHEMBL230796',\n",
    " 'CHEMBL1852155',\n",
    " 'CHEMBL1819181',\n",
    " 'CHEMBL4783030',\n",
    " 'CHEMBL4755141',\n",
    " 'CHEMBL4783761',\n",
    " 'CHEMBL4750160',\n",
    " 'CHEMBL4743003',\n",
    " 'CHEMBL4782080',\n",
    " 'CHEMBL4746252',\n",
    " 'CHEMBL4747494',\n",
    " 'CHEMBL4758659',\n",
    " 'CHEMBL4750983',\n",
    " 'CHEMBL4786809',\n",
    " 'CHEMBL4748787',\n",
    " 'CHEMBL4785236',\n",
    " 'CHEMBL4791666',\n",
    " 'CHEMBL4525466',\n",
    " 'CHEMBL4471585']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "31bb0d77",
   "metadata": {},
   "outputs": [],
   "source": [
    "chem2dis = RetDrugInd(chem)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "1eae6f27",
   "metadata": {
    "scrolled": true
   },
   "outputs": [],
   "source": [
    "chem2mech = RetMech(chem)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "a481e91e",
   "metadata": {},
   "outputs": [],
   "source": [
    "chem2act = RetAct(chem,0)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "51fa67ad",
   "metadata": {},
   "outputs": [],
   "source": [
    "chembl2actmechdis = {}\n",
    "chembl2actmechdis['activity'] = chem2act\n",
    "chembl2actmechdis['mechanism'] = chem2mech\n",
    "chembl2actmechdis['disease']= chem2dis"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "a052b005",
   "metadata": {},
   "outputs": [],
   "source": [
    "# filename = 'data/normalized_data/chembl2actmechdis'\n",
    "# outfile = open(filename,'wb')\n",
    "# pickle.dump(chembl2actmechdis,outfile)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 45,
   "id": "1383a3aa",
   "metadata": {},
   "outputs": [],
   "source": [
    "infile = open('data/normalized_data/chembl2actmechdis','rb')\n",
    "chembl2actmechdis = pickle.load(infile)\n",
    "infile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 46,
   "id": "2f4da688",
   "metadata": {},
   "outputs": [],
   "source": [
    "chem2act = chembl2actmechdis['activity']\n",
    "chem2mech = chembl2actmechdis['mechanism']\n",
    "chem2dis = chembl2actmechdis['disease']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 47,
   "id": "a74204d3",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['CHEMBL1824',\n",
       " 'CHEMBL1791',\n",
       " 'CHEMBL1942',\n",
       " 'CHEMBL217',\n",
       " 'CHEMBL3959',\n",
       " 'CHEMBL614649',\n",
       " 'CHEMBL227',\n",
       " 'CHEMBL4956',\n",
       " 'CHEMBL1293298',\n",
       " 'CHEMBL1867',\n",
       " 'CHEMBL614358',\n",
       " 'CHEMBL2111463',\n",
       " 'CHEMBL2071',\n",
       " 'CHEMBL614274',\n",
       " 'CHEMBL209',\n",
       " 'CHEMBL1803',\n",
       " 'CHEMBL2392',\n",
       " 'CHEMBL385',\n",
       " 'CHEMBL613107',\n",
       " 'CHEMBL249',\n",
       " 'CHEMBL262',\n",
       " 'CHEMBL325',\n",
       " 'CHEMBL5463',\n",
       " 'CHEMBL1293267',\n",
       " 'CHEMBL4685',\n",
       " 'CHEMBL3401',\n",
       " 'CHEMBL2094257',\n",
       " 'CHEMBL1293255',\n",
       " 'CHEMBL3923',\n",
       " 'CHEMBL1697668',\n",
       " 'CHEMBL1293235',\n",
       " 'CHEMBL2421',\n",
       " 'CHEMBL1908',\n",
       " 'CHEMBL1875',\n",
       " 'CHEMBL3227',\n",
       " 'CHEMBL1822',\n",
       " 'CHEMBL4681',\n",
       " 'CHEMBL4523354',\n",
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       " 'CHEMBL1293249',\n",
       " 'CHEMBL1936',\n",
       " 'CHEMBL3729',\n",
       " 'CHEMBL399',\n",
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       " 'CHEMBL2093872',\n",
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       " 'CHEMBL613517',\n",
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       " 'CHEMBL2002',\n",
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       " 'CHEMBL390',\n",
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       " 'CHEMBL240',\n",
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       " 'CHEMBL4204',\n",
       " 'CHEMBL1615322',\n",
       " 'CHEMBL613508',\n",
       " 'CHEMBL225',\n",
       " 'CHEMBL1287622',\n",
       " 'CHEMBL1997',\n",
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       " 'CHEMBL614208',\n",
       " 'CHEMBL2111457',\n",
       " 'CHEMBL3596077',\n",
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       " 'CHEMBL2094109',\n",
       " 'CHEMBL400',\n",
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       " 'CHEMBL3587',\n",
       " 'CHEMBL4096',\n",
       " 'CHEMBL235',\n",
       " 'CHEMBL5162',\n",
       " 'CHEMBL614610',\n",
       " 'CHEMBL3594',\n",
       " 'CHEMBL1293237',\n",
       " 'CHEMBL223',\n",
       " 'CHEMBL1641347',\n",
       " 'CHEMBL1978',\n",
       " 'CHEMBL2094125',\n",
       " 'CHEMBL2095173',\n",
       " 'CHEMBL202',\n",
       " 'CHEMBL242',\n",
       " 'CHEMBL2366156',\n",
       " 'CHEMBL1899',\n",
       " 'CHEMBL1293236',\n",
       " 'CHEMBL2095203',\n",
       " 'CHEMBL3251',\n",
       " 'CHEMBL5843',\n",
       " 'CHEMBL4878',\n",
       " 'CHEMBL1833',\n",
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       " 'CHEMBL1075189',\n",
       " 'CHEMBL260',\n",
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       " 'CHEMBL1827',\n",
       " 'CHEMBL3026',\n",
       " 'CHEMBL3426',\n",
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       " 'CHEMBL2095186',\n",
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       " 'CHEMBL264',\n",
       " 'CHEMBL1293278',\n",
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       " 'CHEMBL215',\n",
       " 'CHEMBL4079',\n",
       " 'CHEMBL287',\n",
       " 'CHEMBL232',\n",
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       " 'CHEMBL3371',\n",
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       " 'CHEMBL614685',\n",
       " 'CHEMBL5905',\n",
       " 'CHEMBL1293226',\n",
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       " 'CHEMBL1994',\n",
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       " 'CHEMBL1907588',\n",
       " 'CHEMBL4234',\n",
       " 'CHEMBL1907589',\n",
       " 'CHEMBL3623',\n",
       " 'CHEMBL614279',\n",
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       " 'CHEMBL238',\n",
       " 'CHEMBL1293232',\n",
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       " 'CHEMBL614177',\n",
       " 'CHEMBL2096670',\n",
       " 'CHEMBL5514',\n",
       " 'CHEMBL614213',\n",
       " 'CHEMBL331',\n",
       " 'CHEMBL614245',\n",
       " 'CHEMBL612250',\n",
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       " 'CHEMBL388',\n",
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       " 'CHEMBL203',\n",
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       " 'CHEMBL256',\n",
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       " 'CHEMBL5847',\n",
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       " 'CHEMBL254',\n",
       " 'CHEMBL3025',\n",
       " 'CHEMBL2664',\n",
       " 'CHEMBL382',\n",
       " 'CHEMBL614255',\n",
       " 'CHEMBL289',\n",
       " 'CHEMBL2014',\n",
       " 'CHEMBL614149',\n",
       " 'CHEMBL6007',\n",
       " 'CHEMBL1293224',\n",
       " 'CHEMBL229',\n",
       " 'CHEMBL1860',\n",
       " 'CHEMBL1916',\n",
       " 'CHEMBL2094124',\n",
       " 'CHEMBL614184',\n",
       " 'CHEMBL612794',\n",
       " 'CHEMBL4429',\n",
       " 'CHEMBL6120',\n",
       " 'CHEMBL4355',\n",
       " 'CHEMBL1782',\n",
       " 'CHEMBL4302',\n",
       " 'CHEMBL4729',\n",
       " 'CHEMBL1293256',\n",
       " 'CHEMBL3629',\n",
       " 'CHEMBL383',\n",
       " 'CHEMBL3622',\n",
       " 'CHEMBL1937',\n",
       " 'CHEMBL2424',\n",
       " 'CHEMBL230',\n",
       " 'CHEMBL2039',\n",
       " 'CHEMBL2097163',\n",
       " 'CHEMBL614879',\n",
       " 'CHEMBL3437',\n",
       " 'CHEMBL4445',\n",
       " 'CHEMBL1808',\n",
       " 'CHEMBL1075138',\n",
       " 'CHEMBL614997',\n",
       " 'CHEMBL4040',\n",
       " 'CHEMBL613977',\n",
       " 'CHEMBL4506',\n",
       " 'CHEMBL1951',\n",
       " 'CHEMBL1829',\n",
       " 'CHEMBL2093863',\n",
       " 'CHEMBL1781',\n",
       " 'CHEMBL3772',\n",
       " 'CHEMBL213',\n",
       " 'CHEMBL4159',\n",
       " 'CHEMBL5141',\n",
       " 'CHEMBL3192',\n",
       " 'CHEMBL3009',\n",
       " 'CHEMBL2637',\n",
       " 'CHEMBL5619',\n",
       " 'CHEMBL4641',\n",
       " 'CHEMBL4499',\n",
       " 'CHEMBL5558',\n",
       " 'CHEMBL1075149',\n",
       " 'CHEMBL2094256',\n",
       " 'CHEMBL3880',\n",
       " 'CHEMBL3759',\n",
       " 'CHEMBL4398',\n",
       " 'CHEMBL614335',\n",
       " 'CHEMBL4235',\n",
       " 'CHEMBL234',\n",
       " 'CHEMBL613827',\n",
       " 'CHEMBL2061',\n",
       " 'CHEMBL1821',\n",
       " 'CHEMBL2093866',\n",
       " 'CHEMBL394',\n",
       " 'CHEMBL231',\n",
       " 'CHEMBL2094',\n",
       " 'CHEMBL614127',\n",
       " 'CHEMBL4179',\n",
       " 'CHEMBL1293299',\n",
       " 'CHEMBL279',\n",
       " 'CHEMBL222',\n",
       " 'CHEMBL217',\n",
       " 'CHEMBL1941',\n",
       " 'CHEMBL2364041',\n",
       " 'CHEMBL2093865',\n",
       " 'CHEMBL227',\n",
       " 'CHEMBL2364028',\n",
       " 'CHEMBL2364704',\n",
       " 'CHEMBL2111463',\n",
       " 'CHEMBL2034',\n",
       " 'CHEMBL2111462',\n",
       " 'CHEMBL220',\n",
       " 'CHEMBL3390826',\n",
       " 'CHEMBL2311224',\n",
       " 'CHEMBL2362972',\n",
       " 'CHEMBL2096972',\n",
       " 'CHEMBL2363064',\n",
       " 'CHEMBL2094124',\n",
       " 'CHEMBL3310',\n",
       " 'CHEMBL2095186',\n",
       " 'CHEMBL6120',\n",
       " 'CHEMBL2821',\n",
       " 'CHEMBL2364679',\n",
       " 'CHEMBL1782',\n",
       " 'CHEMBL2364675',\n",
       " 'CHEMBL249',\n",
       " 'CHEMBL264',\n",
       " 'CHEMBL5375',\n",
       " 'CHEMBL3242',\n",
       " 'CHEMBL215',\n",
       " 'CHEMBL2362989',\n",
       " 'CHEMBL2095200',\n",
       " 'CHEMBL325',\n",
       " 'CHEMBL1874',\n",
       " 'CHEMBL287',\n",
       " 'CHEMBL1937',\n",
       " 'CHEMBL2363076',\n",
       " 'CHEMBL230',\n",
       " 'CHEMBL206',\n",
       " 'CHEMBL2331043',\n",
       " 'CHEMBL3923',\n",
       " 'CHEMBL1994',\n",
       " 'CHEMBL1886',\n",
       " 'CHEMBL1875',\n",
       " 'CHEMBL1808',\n",
       " 'CHEMBL1822',\n",
       " 'CHEMBL1907589',\n",
       " 'CHEMBL2363066',\n",
       " 'CHEMBL218',\n",
       " 'CHEMBL3729',\n",
       " 'CHEMBL2354204',\n",
       " 'CHEMBL2311221',\n",
       " 'CHEMBL2094253',\n",
       " 'CHEMBL2093872',\n",
       " 'CHEMBL613897',\n",
       " 'CHEMBL3391661',\n",
       " 'CHEMBL238',\n",
       " 'CHEMBL1983',\n",
       " 'CHEMBL210',\n",
       " 'CHEMBL1829',\n",
       " 'CHEMBL2362992',\n",
       " 'CHEMBL216',\n",
       " 'CHEMBL2311225',\n",
       " 'CHEMBL2093863',\n",
       " 'CHEMBL5216',\n",
       " 'CHEMBL2023',\n",
       " 'CHEMBL1839',\n",
       " 'CHEMBL1932894',\n",
       " 'CHEMBL4770',\n",
       " 'CHEMBL213',\n",
       " 'CHEMBL3192',\n",
       " 'CHEMBL205',\n",
       " 'CHEMBL2364668',\n",
       " 'CHEMBL2362988',\n",
       " 'CHEMBL2362996',\n",
       " 'CHEMBL243',\n",
       " 'CHEMBL1876',\n",
       " 'CHEMBL1930',\n",
       " 'CHEMBL2364705',\n",
       " 'CHEMBL2094132',\n",
       " 'CHEMBL261',\n",
       " 'CHEMBL1871',\n",
       " 'CHEMBL247',\n",
       " 'CHEMBL2111369',\n",
       " 'CHEMBL2362997',\n",
       " 'CHEMBL1972',\n",
       " 'CHEMBL2363135',\n",
       " 'CHEMBL225',\n",
       " 'CHEMBL1997',\n",
       " 'CHEMBL2331075',\n",
       " 'CHEMBL2364678',\n",
       " 'CHEMBL2111329',\n",
       " 'CHEMBL2363042',\n",
       " 'CHEMBL2363033',\n",
       " 'CHEMBL2120',\n",
       " 'CHEMBL4524006',\n",
       " 'CHEMBL1949',\n",
       " 'CHEMBL245',\n",
       " 'CHEMBL2311222',\n",
       " 'CHEMBL1987',\n",
       " 'CHEMBL228',\n",
       " 'CHEMBL2364702',\n",
       " 'CHEMBL223',\n",
       " 'CHEMBL234',\n",
       " 'CHEMBL2095182',\n",
       " 'CHEMBL4305',\n",
       " 'CHEMBL1780',\n",
       " 'CHEMBL2094125',\n",
       " 'CHEMBL2095158',\n",
       " 'CHEMBL224',\n",
       " 'CHEMBL2093866',\n",
       " 'CHEMBL1952',\n",
       " 'CHEMBL2363073',\n",
       " 'CHEMBL2095229',\n",
       " 'CHEMBL231',\n",
       " 'CHEMBL219',\n",
       " 'CHEMBL2331074',\n",
       " 'CHEMBL301',\n",
       " 'CHEMBL202',\n",
       " 'CHEMBL1872',\n",
       " 'CHEMBL242',\n",
       " 'CHEMBL2095203',\n",
       " 'CHEMBL222']"
      ]
     },
     "execution_count": 47,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "chemid2 = Ret_chembl_protein(chem2act) + Ret_chembl_protein(chem2mech)\n",
    "chemid2"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 48,
   "id": "4f5c77b3",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "old 372\n",
      "newLen 367\n",
      "5\n"
     ]
    }
   ],
   "source": [
    "chem2uni = chembl2uniprot(chemid2,0)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 59,
   "id": "d585fac3",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'CHEMBL1824': [{'xref_id': 'R-HSA-1227986',\n",
       "   'xref_name': 'Signaling by ERBB2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1250196',\n",
       "   'xref_name': 'SHC1 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1251932',\n",
       "   'xref_name': 'PLCG1 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1306955',\n",
       "   'xref_name': 'GRB7 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1358803',\n",
       "   'xref_name': 'Downregulation of ERBB2:ERBB3 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1963640',\n",
       "   'xref_name': 'GRB2 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1963642',\n",
       "   'xref_name': 'PI3K events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2219530',\n",
       "   'xref_name': 'Constitutive Signaling by Aberrant PI3K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416572',\n",
       "   'xref_name': 'Sema4D induced cell migration and growth-cone collapse.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673001',\n",
       "   'xref_name': 'RAF/MAP kinase cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785631',\n",
       "   'xref_name': 'ERBB2 Regulates Cell Motility.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8847993',\n",
       "   'xref_name': 'ERBB2 Activates PTK6 Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8863795',\n",
       "   'xref_name': 'Downregulation of ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8866910',\n",
       "   'xref_name': 'TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9634285',\n",
       "   'xref_name': 'Constitutive Signaling by Overexpressed ERBB2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9652282',\n",
       "   'xref_name': 'Drug-mediated inhibition of ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9664565',\n",
       "   'xref_name': 'Signaling by ERBB2 KD Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665233',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to trastuzumab.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665244',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to sapitinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665245',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to tesevatinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665246',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to neratinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665247',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to osimertinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665249',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to afatinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665250',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to AEE788.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665251',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to lapatinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665348',\n",
       "   'xref_name': 'Signaling by ERBB2 ECD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665686',\n",
       "   'xref_name': 'Signaling by ERBB2 TMD/JMD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665737',\n",
       "   'xref_name': 'Drug resistance in ERBB2 TMD/JMD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P04626'},\n",
       "  {'component_synonym': 'ERBB2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1791': [{'xref_id': 'R-HSA-2672351',\n",
       "   'xref_name': 'Stimuli-sensing channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P37088'},\n",
       "  {'component_synonym': 'SCNN1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1942': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-392023',\n",
       "   'xref_name': 'Adrenaline signalling through Alpha-2 adrenergic receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418597',\n",
       "   'xref_name': 'G alpha (z) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P18089'},\n",
       "  {'component_synonym': 'ADRA2B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL217': [{'xref_id': 'R-HSA-390651',\n",
       "   'xref_name': 'Dopamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P14416'},\n",
       "  {'component_synonym': 'DRD2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3959': [{'xref_id': 'R-HSA-211945',\n",
       "   'xref_name': 'Phase I - Functionalization of compounds.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P16083'},\n",
       "  {'component_synonym': 'NQO2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL227': [{'xref_id': 'R-HSA-375276',\n",
       "   'xref_name': 'Peptide ligand-binding receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856825',\n",
       "   'xref_name': 'Cargo recognition for clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856828',\n",
       "   'xref_name': 'Clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P30556'},\n",
       "  {'component_synonym': 'AGTR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4956': [{'xref_id': 'R-HSA-977443',\n",
       "   'xref_name': 'GABA receptor activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P47869'},\n",
       "  {'component_synonym': 'GABRA2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293298': [{'xref_id': 'R-HSA-9619665',\n",
       "   'xref_name': 'EGR2 and SOX10-mediated initiation of Schwann cell myelination.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q01453'},\n",
       "  {'component_synonym': 'PMP22', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1867': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-392023',\n",
       "   'xref_name': 'Adrenaline signalling through Alpha-2 adrenergic receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400042',\n",
       "   'xref_name': 'Adrenaline,noradrenaline inhibits insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418597',\n",
       "   'xref_name': 'G alpha (z) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5683826',\n",
       "   'xref_name': 'Surfactant metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08913'},\n",
       "  {'component_synonym': 'ADRA2A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2111463': [{'xref_id': 'R-HSA-1296041',\n",
       "   'xref_name': 'Activation of G protein gated Potassium channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-420499',\n",
       "   'xref_name': 'Class C/3 (Metabotropic glutamate/pheromone receptors).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-977444',\n",
       "   'xref_name': 'GABA B receptor activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-997272',\n",
       "   'xref_name': 'Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9UBS5'},\n",
       "  {'component_synonym': 'GABBR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2071': [{'xref_id': 'R-HSA-1296025',\n",
       "   'xref_name': 'ATP sensitive Potassium channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-422356',\n",
       "   'xref_name': 'Regulation of insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5683177',\n",
       "   'xref_name': 'Defective ABCC8 can cause hypo- and hyper-glycemias.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q09428'},\n",
       "  {'component_synonym': 'ABCC8', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL209': [{'xref_id': 'R-HSA-1592389',\n",
       "   'xref_name': 'Activation of Matrix Metalloproteinases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-196741',\n",
       "   'xref_name': 'Cobalamin (Cbl, vitamin B12) transport and metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P07477'},\n",
       "  {'component_synonym': 'PRSS1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1803': [{'xref_id': 'R-HSA-198933',\n",
       "   'xref_name': 'Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202733',\n",
       "   'xref_name': 'Cell surface interactions at the vascular wall.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-216083',\n",
       "   'xref_name': 'Integrin cell surface interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8949275',\n",
       "   'xref_name': 'RUNX3 Regulates Immune Response and Cell Migration.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20701'},\n",
       "  {'component_synonym': 'ITGAL', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2392': [{'xref_id': 'R-HSA-110362',\n",
       "   'xref_name': 'POLB-Dependent Long Patch Base Excision Repair.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-110373',\n",
       "   'xref_name': 'Resolution of AP sites via the multiple-nucleotide patch replacement pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-110381',\n",
       "   'xref_name': 'Resolution of AP sites via the single-nucleotide replacement pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5649702',\n",
       "   'xref_name': 'APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5651801',\n",
       "   'xref_name': 'PCNA-Dependent Long Patch Base Excision Repair.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689880',\n",
       "   'xref_name': 'Ub-specific processing proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73930',\n",
       "   'xref_name': 'Abasic sugar-phosphate removal via the single-nucleotide replacement pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P06746'},\n",
       "  {'component_synonym': 'POLB', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL249': [{'xref_id': 'R-HSA-380095',\n",
       "   'xref_name': 'Tachykinin receptors bind tachykinins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856825',\n",
       "   'xref_name': 'Cargo recognition for clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856828',\n",
       "   'xref_name': 'Clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P25103'},\n",
       "  {'component_synonym': 'TACR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL262': [{'xref_id': 'R-HSA-195253',\n",
       "   'xref_name': 'Degradation of beta-catenin by the destruction complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-196299',\n",
       "   'xref_name': 'Beta-catenin phosphorylation cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-198323',\n",
       "   'xref_name': 'AKT phosphorylates targets in the cytosol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371453',\n",
       "   'xref_name': 'Regulation of HSF1-mediated heat shock response.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-399956',\n",
       "   'xref_name': 'CRMPs in Sema3A signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4641262',\n",
       "   'xref_name': 'Disassembly of the destruction complex and recruitment of AXIN to the membrane.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5250924',\n",
       "   'xref_name': 'B-WICH complex positively regulates rRNA expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5339716',\n",
       "   'xref_name': 'Signaling by GSK3beta mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5358747',\n",
       "   'xref_name': \"S33 mutants of beta-catenin aren't phosphorylated.\",\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5358749',\n",
       "   'xref_name': \"S37 mutants of beta-catenin aren't phosphorylated.\",\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5358751',\n",
       "   'xref_name': \"S45 mutants of beta-catenin aren't phosphorylated.\",\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5358752',\n",
       "   'xref_name': \"T41 mutants of beta-catenin aren't phosphorylated.\",\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5467337',\n",
       "   'xref_name': 'APC truncation mutants have impaired AXIN binding.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5467340',\n",
       "   'xref_name': 'AXIN missense mutants destabilize the destruction complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5467348',\n",
       "   'xref_name': 'Truncations of AMER1 destabilize the destruction complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5610783',\n",
       "   'xref_name': 'Degradation of GLI2 by the proteasome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5610785',\n",
       "   'xref_name': 'GLI3 is processed to GLI3R by the proteasome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5674400',\n",
       "   'xref_name': 'Constitutive Signaling by AKT1 E17K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-75815',\n",
       "   'xref_name': 'Ubiquitin-dependent degradation of Cyclin D.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939902',\n",
       "   'xref_name': 'Regulation of RUNX2 expression and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9682706',\n",
       "   'xref_name': 'Replication of the SARS-CoV-1 genome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9683610',\n",
       "   'xref_name': 'Maturation of nucleoprotein.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9694631',\n",
       "   'xref_name': 'Maturation of nucleoprotein.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9694686',\n",
       "   'xref_name': 'Replication of the SARS-CoV-2 genome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P49841'},\n",
       "  {'component_synonym': 'GSK3B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL325': [{'xref_id': 'R-HSA-1362277',\n",
       "   'xref_name': 'Transcription of E2F targets under negative control by DREAM complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1362300',\n",
       "   'xref_name': 'Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1538133',\n",
       "   'xref_name': 'G0 and Early G1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193670',\n",
       "   'xref_name': 'p75NTR negatively regulates cell cycle via SC1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-201722',\n",
       "   'xref_name': 'Formation of the beta-catenin:TCF transactivating complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2122947',\n",
       "   'xref_name': 'NOTCH1 Intracellular Domain Regulates Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2173795',\n",
       "   'xref_name': 'Downregulation of SMAD2/3:SMAD4 transcriptional activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2173796',\n",
       "   'xref_name': 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2644606',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2894862',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214815',\n",
       "   'xref_name': 'HDACs deacetylate histones.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-350054',\n",
       "   'xref_name': 'Notch-HLH transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3769402',\n",
       "   'xref_name': 'Deactivation of the beta-catenin transactivating complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-427389',\n",
       "   'xref_name': 'ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-427413',\n",
       "   'xref_name': 'NoRC negatively regulates rRNA expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4551638',\n",
       "   'xref_name': 'SUMOylation of chromatin organization proteins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4641265',\n",
       "   'xref_name': 'Repression of WNT target genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804758',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Acetylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69205',\n",
       "   'xref_name': 'G1/S-Specific Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73762',\n",
       "   'xref_name': 'RNA Polymerase I Transcription Initiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8936459',\n",
       "   'xref_name': 'RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8943724',\n",
       "   'xref_name': 'Regulation of PTEN gene transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018519',\n",
       "   'xref_name': 'Estrogen-dependent gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022538',\n",
       "   'xref_name': 'Loss of MECP2 binding ability to 5mC-DNA.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022692',\n",
       "   'xref_name': 'Regulation of MECP2 expression and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022699',\n",
       "   'xref_name': 'MECP2 regulates neuronal receptors and channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022702',\n",
       "   'xref_name': 'MECP2 regulates transcription of neuronal ligands.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9615017',\n",
       "   'xref_name': 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983231',\n",
       "   'xref_name': 'Factors involved in megakaryocyte development and platelet production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13547'},\n",
       "  {'component_synonym': 'HDAC1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5463': [{'xref_id': 'R-HSA-1660662',\n",
       "   'xref_name': 'Glycosphingolipid metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13510'},\n",
       "  {'component_synonym': 'ASAH1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293267': [{'xref_id': 'R-HSA-373076',\n",
       "   'xref_name': 'Class A/1 (Rhodopsin-like receptors).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9HC97'},\n",
       "  {'component_synonym': 'GPR35', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4685': [{'xref_id': 'R-HSA-71240',\n",
       "   'xref_name': 'Tryptophan catabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P14902'},\n",
       "  {'component_synonym': 'IDO1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3401': [{'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors. [O75469-1]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O75469'},\n",
       "  {'component_synonym': 'NR1I2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094257': [{'xref_id': 'R-HSA-417973',\n",
       "   'xref_name': 'Adenosine P1 receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5683826',\n",
       "   'xref_name': 'Surfactant metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P29275'},\n",
       "  {'component_synonym': 'ADORA2B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293255': [{'xref_id': 'R-HSA-2142700',\n",
       "   'xref_name': 'Synthesis of Lipoxins (LX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2162123',\n",
       "   'xref_name': 'Synthesis of Prostaglandins (PG) and Thromboxanes (TX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018676',\n",
       "   'xref_name': 'Biosynthesis of D-series resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018896',\n",
       "   'xref_name': 'Biosynthesis of E-series 18(S)-resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P15428'},\n",
       "  {'component_synonym': 'HPGD', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3923': [{'xref_id': 'R-HSA-9013149',\n",
       "   'xref_name': 'RAC1 GTPase cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9696264',\n",
       "   'xref_name': 'RND3 GTPase cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9696270',\n",
       "   'xref_name': 'RND2 GTPase cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9Y2I1'},\n",
       "  {'component_synonym': 'NISCH', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1697668': [{'xref_id': 'R-HSA-159418',\n",
       "   'xref_name': 'Recycling of bile acids and salts.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-189483',\n",
       "   'xref_name': 'Heme degradation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5619110',\n",
       "   'xref_name': 'Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-879518',\n",
       "   'xref_name': 'Transport of organic anions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9Y6L6'},\n",
       "  {'component_synonym': 'SLCO1B1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293235': [{'xref_id': 'R-HSA-1221632',\n",
       "   'xref_name': 'Meiotic synapsis. [P02545-2]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2980766',\n",
       "   'xref_name': 'Nuclear Envelope Breakdown.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2995383',\n",
       "   'xref_name': 'Initiation of Nuclear Envelope (NE) Reformation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-352238',\n",
       "   'xref_name': 'Breakdown of the nuclear lamina. [P02545-1]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381038',\n",
       "   'xref_name': 'XBP1(S) activates chaperone genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4419969',\n",
       "   'xref_name': 'Depolymerisation of the Nuclear Lamina.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802952',\n",
       "   'xref_name': 'Signaling by BRAF and RAF fusions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8862803',\n",
       "   'xref_name': \"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models. [P02545-1]\",\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P02545'},\n",
       "  {'component_synonym': 'LMNA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2421': [{'xref_id': 'R-HSA-194002',\n",
       "   'xref_name': 'Glucocorticoid biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08185'},\n",
       "  {'component_synonym': 'SERPINA6', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1908': [{'xref_id': 'R-HSA-194002',\n",
       "   'xref_name': 'Glucocorticoid biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211976',\n",
       "   'xref_name': 'Endogenous sterols.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5579017',\n",
       "   'xref_name': 'Defective CYP11B1 causes AH4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P15538'},\n",
       "  {'component_synonym': 'CYP11B1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1875': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13639'},\n",
       "  {'component_synonym': 'HTR4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3227': [{'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-420499',\n",
       "   'xref_name': 'Class C/3 (Metabotropic glutamate/pheromone receptors).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6794361',\n",
       "   'xref_name': 'Neurexins and neuroligins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P41594'},\n",
       "  {'component_synonym': 'GRM5', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1822': [{'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73817',\n",
       "   'xref_name': 'Purine ribonucleoside monophosphate biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20839'},\n",
       "  {'component_synonym': 'IMPDH1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4681': [{'xref_id': 'R-HSA-193368',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193775',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 24-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193807',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 27-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2162123',\n",
       "   'xref_name': 'Synthesis of Prostaglandins (PG) and Thromboxanes (TX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5365859',\n",
       "   'xref_name': 'RA biosynthesis pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-975634',\n",
       "   'xref_name': 'Retinoid metabolism and transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P42330'},\n",
       "  {'component_synonym': 'AKR1C3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4523354': [{'xref_id': 'R-HSA-197264',\n",
       "   'xref_name': 'Nicotinamide salvaging.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q6XQN6'},\n",
       "  {'component_synonym': 'NAPRT', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293249': [{'xref_id': 'R-HSA-381340',\n",
       "   'xref_name': 'Transcriptional regulation of white adipocyte differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9616222',\n",
       "   'xref_name': 'Transcriptional regulation of granulopoiesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13887'},\n",
       "  {'component_synonym': 'KLF5', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1936': [{'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1433557',\n",
       "   'xref_name': 'Signaling by SCF-KIT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1433559',\n",
       "   'xref_name': 'Regulation of KIT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2219530',\n",
       "   'xref_name': 'Constitutive Signaling by Aberrant PI3K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673001',\n",
       "   'xref_name': 'RAF/MAP kinase cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8866910',\n",
       "   'xref_name': 'TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669914',\n",
       "   'xref_name': 'Dasatinib-resistant KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669917',\n",
       "   'xref_name': 'Imatinib-resistant KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669921',\n",
       "   'xref_name': 'KIT mutants bind TKIs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669924',\n",
       "   'xref_name': 'Masitinib-resistant KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669926',\n",
       "   'xref_name': 'Nilotinib-resistant KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669929',\n",
       "   'xref_name': 'Regorafenib-resistant KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669933',\n",
       "   'xref_name': 'Signaling by kinase domain mutants of KIT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669934',\n",
       "   'xref_name': 'Sunitinib-resistant KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669935',\n",
       "   'xref_name': 'Signaling by juxtamembrane domain KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9669936',\n",
       "   'xref_name': 'Sorafenib-resistant KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9670439',\n",
       "   'xref_name': 'Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9680187',\n",
       "   'xref_name': 'Signaling by extracellular domain mutants of KIT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P10721'},\n",
       "  {'component_synonym': 'KIT', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3729': [{'xref_id': 'R-HSA-1237044',\n",
       "   'xref_name': 'Erythrocytes take up carbon dioxide and release oxygen.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1247673',\n",
       "   'xref_name': 'Erythrocytes take up oxygen and release carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P22748'},\n",
       "  {'component_synonym': 'CA4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5112': [{'xref_id': 'R-HSA-977443',\n",
       "   'xref_name': 'GABA receptor activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P31644'},\n",
       "  {'component_synonym': 'GABRA5', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2093872': [{'xref_id': 'R-HSA-1236394',\n",
       "   'xref_name': 'Signaling by ERBB4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-977443',\n",
       "   'xref_name': 'GABA receptor activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P14867'},\n",
       "  {'component_synonym': 'GABRA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3746': [{'xref_id': 'R-HSA-194002',\n",
       "   'xref_name': 'Glucocorticoid biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P80365'},\n",
       "  {'component_synonym': 'HSD11B2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2093861': [{'xref_id': 'R-HSA-201722',\n",
       "   'xref_name': 'Formation of the beta-catenin:TCF transactivating complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2173796',\n",
       "   'xref_name': 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3769402',\n",
       "   'xref_name': 'Deactivation of the beta-catenin transactivating complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381426',\n",
       "   'xref_name': 'Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5626467',\n",
       "   'xref_name': 'RHO GTPases activate IQGAPs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8957275',\n",
       "   'xref_name': 'Post-translational protein phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O00255'},\n",
       "  {'component_synonym': 'MEN1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2023': [{'xref_id': 'R-HSA-156581',\n",
       "   'xref_name': 'Methylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-379397',\n",
       "   'xref_name': 'Enzymatic degradation of dopamine by COMT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-379398',\n",
       "   'xref_name': 'Enzymatic degradation of Dopamine by monoamine oxidase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P21964'},\n",
       "  {'component_synonym': 'COMT', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2002': [{'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73817',\n",
       "   'xref_name': 'Purine ribonucleoside monophosphate biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P12268'},\n",
       "  {'component_synonym': 'IMPDH2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3577': [{'xref_id': 'R-HSA-5365859',\n",
       "   'xref_name': 'RA biosynthesis pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-70350',\n",
       "   'xref_name': 'Fructose catabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-71384',\n",
       "   'xref_name': 'Ethanol oxidation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00352'},\n",
       "  {'component_synonym': 'ALDH1A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL340': [{'xref_id': 'R-HSA-211981',\n",
       "   'xref_name': 'Xenobiotics.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5423646',\n",
       "   'xref_name': 'Aflatoxin activation and detoxification.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027307',\n",
       "   'xref_name': 'Biosynthesis of maresin-like SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08684'},\n",
       "  {'component_synonym': 'CYP3A4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2903': [{'xref_id': 'R-HSA-2142691',\n",
       "   'xref_name': 'Synthesis of Leukotrienes (LT) and Eoxins (EX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142712',\n",
       "   'xref_name': 'Synthesis of 12-eicosatetraenoic acid derivatives.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142770',\n",
       "   'xref_name': 'Synthesis of 15-eicosatetraenoic acid derivatives.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785807',\n",
       "   'xref_name': 'Interleukin-4 and Interleukin-13 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018677',\n",
       "   'xref_name': 'Biosynthesis of DHA-derived SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018681',\n",
       "   'xref_name': 'Biosynthesis of protectins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018896',\n",
       "   'xref_name': 'Biosynthesis of E-series 18(S)-resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9023661',\n",
       "   'xref_name': 'Biosynthesis of E-series 18(R)-resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9025106',\n",
       "   'xref_name': 'Biosynthesis of DPAn-6 SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9026286',\n",
       "   'xref_name': 'Biosynthesis of DPAn-3-derived protectins and resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P16050'},\n",
       "  {'component_synonym': 'ALOX15', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094132': [{'xref_id': 'R-HSA-112314',\n",
       "   'xref_name': 'Neurotransmitter receptors and postsynaptic signal transmission.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P46098'},\n",
       "  {'component_synonym': 'HTR3A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1871': [{'xref_id': 'R-HSA-3371497',\n",
       "   'xref_name': 'HSP90 chaperone cycle for steroid hormone receptors (SHR).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5625886',\n",
       "   'xref_name': 'Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689880',\n",
       "   'xref_name': 'Ub-specific processing proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8940973',\n",
       "   'xref_name': 'RUNX2 regulates osteoblast differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P10275'},\n",
       "  {'component_synonym': 'AR', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL221': [{'xref_id': 'R-HSA-140180',\n",
       "   'xref_name': 'COX reactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2162123',\n",
       "   'xref_name': 'Synthesis of Prostaglandins (PG) and Thromboxanes (TX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P23219'},\n",
       "  {'component_synonym': 'PTGS1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1898': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P28222'},\n",
       "  {'component_synonym': 'HTR1B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1801': [{'xref_id': 'R-HSA-114608',\n",
       "   'xref_name': 'Platelet degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1474228',\n",
       "   'xref_name': 'Degradation of the extracellular matrix.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1592389',\n",
       "   'xref_name': 'Activation of Matrix Metalloproteinases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-186797',\n",
       "   'xref_name': 'Signaling by PDGF.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381426',\n",
       "   'xref_name': 'Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-75205',\n",
       "   'xref_name': 'Dissolution of Fibrin Clot.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00747'},\n",
       "  {'component_synonym': 'PLG', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3832943': [{'xref_id': 'R-HSA-1483191',\n",
       "   'xref_name': 'Synthesis of PC.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-201688',\n",
       "   'xref_name': 'WNT mediated activation of DVL.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2514853',\n",
       "   'xref_name': 'Condensation of Prometaphase Chromosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-445144',\n",
       "   'xref_name': 'Signal transduction by L1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804756',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6814122',\n",
       "   'xref_name': 'Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8932339',\n",
       "   'xref_name': 'ROS sensing by NFE2L2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8934903',\n",
       "   'xref_name': 'Receptor Mediated Mitophagy.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939243',\n",
       "   'xref_name': 'RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8948751',\n",
       "   'xref_name': 'Regulation of PTEN stability and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P67870'},\n",
       "  {'component_synonym': 'CSNK2B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094251': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416482',\n",
       "   'xref_name': 'G alpha (12/13) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35348'},\n",
       "  {'component_synonym': 'ADRA1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3902': [{'xref_id': 'R-HSA-156590',\n",
       "   'xref_name': 'Glutathione conjugation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3299685',\n",
       "   'xref_name': 'Detoxification of Reactive Oxygen Species.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P09211'},\n",
       "  {'component_synonym': 'GSTP1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL228': [{'xref_id': 'R-HSA-380615',\n",
       "   'xref_name': 'Serotonin clearance from the synaptic cleft.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P31645'},\n",
       "  {'component_synonym': 'SLC6A4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4550': [{'xref_id': 'R-HSA-2142688',\n",
       "   'xref_name': 'Synthesis of 5-eicosatetraenoic acids.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142691',\n",
       "   'xref_name': 'Synthesis of Leukotrienes (LT) and Eoxins (EX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142700',\n",
       "   'xref_name': 'Synthesis of Lipoxins (LX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20292'},\n",
       "  {'component_synonym': 'ALOX5AP', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2095158': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-392023',\n",
       "   'xref_name': 'Adrenaline signalling through Alpha-2 adrenergic receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400042',\n",
       "   'xref_name': 'Adrenaline,noradrenaline inhibits insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418597',\n",
       "   'xref_name': 'G alpha (z) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5683826',\n",
       "   'xref_name': 'Surfactant metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08913'},\n",
       "  {'component_synonym': 'ADRA2A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1902': [{'xref_id': 'R-HSA-166208',\n",
       "   'xref_name': 'mTORC1-mediated signalling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2025928',\n",
       "   'xref_name': 'Calcineurin activates NFAT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2173789',\n",
       "   'xref_name': 'TGF-beta receptor signaling activates SMADs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2173791',\n",
       "   'xref_name': 'TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3656535',\n",
       "   'xref_name': 'TGFBR1 LBD Mutants in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P62942'},\n",
       "  {'component_synonym': 'FKBP1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2231': [{'xref_id': 'R-HSA-1989781',\n",
       "   'xref_name': 'PPARA activates gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211981',\n",
       "   'xref_name': 'Xenobiotics.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142670',\n",
       "   'xref_name': 'Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142816',\n",
       "   'xref_name': 'Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018681',\n",
       "   'xref_name': 'Biosynthesis of protectins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P04798'},\n",
       "  {'component_synonym': 'CYP1A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2095229': [{'xref_id': 'R-HSA-400042',\n",
       "   'xref_name': 'Adrenaline,noradrenaline inhibits insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-419037',\n",
       "   'xref_name': 'NCAM1 interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-422356',\n",
       "   'xref_name': 'Regulation of insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576892',\n",
       "   'xref_name': 'Phase 0 - rapid depolarisation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576893',\n",
       "   'xref_name': 'Phase 2 - plateau phase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13936'},\n",
       "  {'component_synonym': 'CACNA1C', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2056': [{'xref_id': 'R-HSA-390651',\n",
       "   'xref_name': 'Dopamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P21728'},\n",
       "  {'component_synonym': 'DRD1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL301': [{'xref_id': 'R-HSA-1538133',\n",
       "   'xref_name': 'G0 and Early G1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-171319',\n",
       "   'xref_name': 'Telomere Extension By Telomerase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-176187',\n",
       "   'xref_name': 'Activation of ATR in response to replication stress.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-176408',\n",
       "   'xref_name': 'Regulation of APC/C activators between G1/S and early anaphase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-187577',\n",
       "   'xref_name': 'SCF(Skp2)-mediated degradation of p27/p21.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559582',\n",
       "   'xref_name': 'Senescence-Associated Secretory Phenotype (SASP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559586',\n",
       "   'xref_name': 'DNA Damage/Telomere Stress Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5693607',\n",
       "   'xref_name': 'Processing of DNA double-strand break ends.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804116',\n",
       "   'xref_name': 'TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804756',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804757',\n",
       "   'xref_name': 'Regulation of TP53 Degradation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-68911',\n",
       "   'xref_name': 'G2 Phase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-68949',\n",
       "   'xref_name': 'Orc1 removal from chromatin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-68962',\n",
       "   'xref_name': 'Activation of the pre-replicative complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69017',\n",
       "   'xref_name': 'CDK-mediated phosphorylation and removal of Cdc6.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69200',\n",
       "   'xref_name': 'Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69202',\n",
       "   'xref_name': 'Cyclin E associated events during G1/S transition.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69231',\n",
       "   'xref_name': 'Cyclin D associated events in G1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69273',\n",
       "   'xref_name': 'Cyclin A/B1/B2 associated events during G2/M transition.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69563',\n",
       "   'xref_name': 'p53-Dependent G1 DNA Damage Response.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69656',\n",
       "   'xref_name': 'Cyclin A:Cdk2-associated events at S phase entry.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8849470',\n",
       "   'xref_name': 'PTK6 Regulates Cell Cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-912446',\n",
       "   'xref_name': 'Meiotic recombination.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9616222',\n",
       "   'xref_name': 'Transcriptional regulation of granulopoiesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9661069',\n",
       "   'xref_name': 'Defective binding of RB1 mutants to E2F1,(E2F2, E2F3).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983231',\n",
       "   'xref_name': 'Factors involved in megakaryocyte development and platelet production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P24941'},\n",
       "  {'component_synonym': 'CDK2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3883320': [{'xref_id': 'R-HSA-3214841',\n",
       "   'xref_name': 'PKMTs methylate histone lysines.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214847',\n",
       "   'xref_name': 'HATs acetylate histones.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214858',\n",
       "   'xref_name': 'RMTs methylate histone arginines.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5617472',\n",
       "   'xref_name': 'Activation of anterior HOX genes in hindbrain development during early embryogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8936459',\n",
       "   'xref_name': 'RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8951664',\n",
       "   'xref_name': 'Neddylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P61964'},\n",
       "  {'component_synonym': 'WDR5', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4522': [{'accession': 'Q9NSY1'},\n",
       "  {'component_synonym': 'BMP2K', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094127': [{'xref_id': 'R-HSA-110056',\n",
       "   'xref_name': 'MAPK3 (ERK1) activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-113507',\n",
       "   'xref_name': 'E2F-enabled inhibition of pre-replication complex formation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1362300',\n",
       "   'xref_name': 'Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-162658',\n",
       "   'xref_name': 'Golgi Cisternae Pericentriolar Stack Reorganization.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-170145',\n",
       "   'xref_name': 'Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-174048',\n",
       "   'xref_name': 'APC/C:Cdc20 mediated degradation of Cyclin B.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-174184',\n",
       "   'xref_name': 'Cdc20:Phospho-APC/C mediated degradation of Cyclin A.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-176408',\n",
       "   'xref_name': 'Regulation of APC/C activators between G1/S and early anaphase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-176412',\n",
       "   'xref_name': 'Phosphorylation of the APC/C.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-176417',\n",
       "   'xref_name': 'Phosphorylation of Emi1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2299718',\n",
       "   'xref_name': 'Condensation of Prophase Chromosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2465910',\n",
       "   'xref_name': 'MASTL Facilitates Mitotic Progression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2500257',\n",
       "   'xref_name': 'Resolution of Sister Chromatid Cohesion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2514853',\n",
       "   'xref_name': 'Condensation of Prometaphase Chromosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2565942',\n",
       "   'xref_name': 'Regulation of PLK1 Activity at G2/M Transition.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2980767',\n",
       "   'xref_name': 'Activation of NIMA Kinases NEK9, NEK6, NEK7.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2995383',\n",
       "   'xref_name': 'Initiation of Nuclear Envelope (NE) Reformation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3301854',\n",
       "   'xref_name': 'Nuclear Pore Complex (NPC) Disassembly.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380259',\n",
       "   'xref_name': 'Loss of Nlp from mitotic centrosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380270',\n",
       "   'xref_name': 'Recruitment of mitotic centrosome proteins and complexes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380284',\n",
       "   'xref_name': 'Loss of proteins required for interphase microtubule organization from the centrosome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380320',\n",
       "   'xref_name': 'Recruitment of NuMA to mitotic centrosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4419969',\n",
       "   'xref_name': 'Depolymerisation of the Nuclear Lamina.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5620912',\n",
       "   'xref_name': 'Anchoring of the basal body to the plasma membrane.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5687128',\n",
       "   'xref_name': 'MAPK6/MAPK4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689896',\n",
       "   'xref_name': 'Ovarian tumor domain proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804114',\n",
       "   'xref_name': 'TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804757',\n",
       "   'xref_name': 'Regulation of TP53 Degradation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-68875',\n",
       "   'xref_name': 'Mitotic Prophase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69205',\n",
       "   'xref_name': 'G1/S-Specific Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69273',\n",
       "   'xref_name': 'Cyclin A/B1/B2 associated events during G2/M transition.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69478',\n",
       "   'xref_name': 'G2/M DNA replication checkpoint.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-75035',\n",
       "   'xref_name': 'Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8852276',\n",
       "   'xref_name': 'The role of GTSE1 in G2/M progression after G2 checkpoint.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8854518',\n",
       "   'xref_name': 'AURKA Activation by TPX2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8878166',\n",
       "   'xref_name': 'Transcriptional regulation by RUNX2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P06493'},\n",
       "  {'component_synonym': 'CDK1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2736': [{'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-420499',\n",
       "   'xref_name': 'Class C/3 (Metabotropic glutamate/pheromone receptors).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q14833'},\n",
       "  {'component_synonym': 'GRM4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1941': [{'xref_id': 'R-HSA-390650',\n",
       "   'xref_name': 'Histamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P25021'},\n",
       "  {'component_synonym': 'HRH2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2608': [{'xref_id': 'R-HSA-5357609',\n",
       "   'xref_name': 'Glycogen storage disease type II (GAA).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-70221',\n",
       "   'xref_name': 'Glycogen breakdown (glycogenolysis).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P10253'},\n",
       "  {'component_synonym': 'GAA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4422': [{'xref_id': 'R-HSA-381771',\n",
       "   'xref_name': 'Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400511',\n",
       "   'xref_name': 'Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-434316',\n",
       "   'xref_name': 'Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-444209',\n",
       "   'xref_name': 'Free fatty acid receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O14842'},\n",
       "  {'component_synonym': 'FFAR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL253': [{'xref_id': 'R-HSA-373076',\n",
       "   'xref_name': 'Class A/1 (Rhodopsin-like receptors).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P34972'},\n",
       "  {'component_synonym': 'CNR2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4261': [{'xref_id': 'R-HSA-1234158',\n",
       "   'xref_name': 'Regulation of gene expression by Hypoxia-inducible Factor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1234174',\n",
       "   'xref_name': 'Cellular response to hypoxia.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1234176',\n",
       "   'xref_name': 'Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2122947',\n",
       "   'xref_name': 'NOTCH1 Intracellular Domain Regulates Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400253',\n",
       "   'xref_name': 'Circadian Clock.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689880',\n",
       "   'xref_name': 'Ub-specific processing proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785807',\n",
       "   'xref_name': 'Interleukin-4 and Interleukin-13 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8849473',\n",
       "   'xref_name': 'PTK6 Expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8857538',\n",
       "   'xref_name': 'PTK6 promotes HIF1A stabilization.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8951664',\n",
       "   'xref_name': 'Neddylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q16665'},\n",
       "  {'component_synonym': 'HIF1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3849': [{'xref_id': 'R-HSA-191273',\n",
       "   'xref_name': 'Cholesterol biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211976',\n",
       "   'xref_name': 'Endogenous sterols.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2426168',\n",
       "   'xref_name': 'Activation of gene expression by SREBF (SREBP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9619665',\n",
       "   'xref_name': 'EGR2 and SOX10-mediated initiation of Schwann cell myelination.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q16850'},\n",
       "  {'component_synonym': 'CYP51A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3913': [{'xref_id': 'R-HSA-166663',\n",
       "   'xref_name': 'Initial triggering of complement.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-173623',\n",
       "   'xref_name': 'Classical antibody-mediated complement activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-977606',\n",
       "   'xref_name': 'Regulation of Complement cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P09871'},\n",
       "  {'component_synonym': 'C1S', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL214': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08908'},\n",
       "  {'component_synonym': 'HTR1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4931': [{'xref_id': 'R-HSA-6807047',\n",
       "   'xref_name': 'Cholesterol biosynthesis via desmosterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6807062',\n",
       "   'xref_name': 'Cholesterol biosynthesis via lathosterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q15125'},\n",
       "  {'component_synonym': 'EBP', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3683': [{'xref_id': 'R-HSA-451307',\n",
       "   'xref_name': 'Activation of Na-permeable kainate receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-451308',\n",
       "   'xref_name': 'Activation of Ca-permeable Kainate Receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13002'},\n",
       "  {'component_synonym': 'GRIK2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4523454': [{'xref_id': 'R-HSA-381753',\n",
       "   'xref_name': 'Olfactory Signaling Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9H255'},\n",
       "  {'component_synonym': 'OR51E2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1918': [{'xref_id': 'R-HSA-451307',\n",
       "   'xref_name': 'Activation of Na-permeable kainate receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-451308',\n",
       "   'xref_name': 'Activation of Ca-permeable Kainate Receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P39086'},\n",
       "  {'component_synonym': 'GRIK1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1947': [{'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P10828'},\n",
       "  {'component_synonym': 'THRB', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094115': [{'xref_id': 'R-HSA-168638',\n",
       "   'xref_name': 'NOD1/2 Signaling Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-171007',\n",
       "   'xref_name': 'p38MAPK events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-376172',\n",
       "   'xref_name': 'DSCAM interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4420097',\n",
       "   'xref_name': 'VEGFA-VEGFR2 Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O15264'},\n",
       "  {'component_synonym': 'MAPK13', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2096905': [{'xref_id': 'R-HSA-390651',\n",
       "   'xref_name': 'Dopamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P14416'},\n",
       "  {'component_synonym': 'DRD2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1963': [{'xref_id': 'R-HSA-375281',\n",
       "   'xref_name': 'Hormone ligand-binding receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P16473'},\n",
       "  {'component_synonym': 'TSHR', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2096682': [{'xref_id': 'R-HSA-445095',\n",
       "   'xref_name': 'Interaction between L1 and Ankyrins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576892',\n",
       "   'xref_name': 'Phase 0 - rapid depolarisation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35498'},\n",
       "  {'component_synonym': 'SCN1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2842': [{'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1632852',\n",
       "   'xref_name': 'Macroautophagy.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-165159',\n",
       "   'xref_name': 'MTOR signalling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-166208',\n",
       "   'xref_name': 'mTORC1-mediated signalling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371571',\n",
       "   'xref_name': 'HSF1-dependent transactivation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380972',\n",
       "   'xref_name': 'Energy dependent regulation of mTOR by LKB1-AMPK.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-389357',\n",
       "   'xref_name': 'CD28 dependent PI3K/Akt signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5218920',\n",
       "   'xref_name': 'VEGFR2 mediated vascular permeability.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5628897',\n",
       "   'xref_name': 'TP53 Regulates Metabolic Genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5674400',\n",
       "   'xref_name': 'Constitutive Signaling by AKT1 E17K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804757',\n",
       "   'xref_name': 'Regulation of TP53 Degradation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8943724',\n",
       "   'xref_name': 'Regulation of PTEN gene transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9639288',\n",
       "   'xref_name': 'Amino acids regulate mTORC1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P42345'},\n",
       "  {'component_synonym': 'MTOR', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL206': [{'xref_id': 'R-HSA-1251985',\n",
       "   'xref_name': 'Nuclear signaling by ERBB4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2219530',\n",
       "   'xref_name': 'Constitutive Signaling by Aberrant PI3K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689896',\n",
       "   'xref_name': 'Ovarian tumor domain proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8866910',\n",
       "   'xref_name': 'TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8931987',\n",
       "   'xref_name': 'RUNX1 regulates estrogen receptor mediated transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939211',\n",
       "   'xref_name': 'ESR-mediated signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939256',\n",
       "   'xref_name': 'RUNX1 regulates transcription of genes involved in WNT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939902',\n",
       "   'xref_name': 'Regulation of RUNX2 expression and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9009391',\n",
       "   'xref_name': 'Extra-nuclear estrogen signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018519',\n",
       "   'xref_name': 'Estrogen-dependent gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P03372'},\n",
       "  {'component_synonym': 'ESR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4105907': [{'accession': 'Q5BJF2'},\n",
       "  {'component_synonym': 'TMEM97', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1641348': [{'xref_id': 'R-HSA-561048',\n",
       "   'xref_name': 'Organic anion transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q8TCC7'},\n",
       "  {'component_synonym': 'SLC22A8', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293294': [{'xref_id': 'R-HSA-6811440',\n",
       "   'xref_name': 'Retrograde transport at the Trans-Golgi-Network.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8873719',\n",
       "   'xref_name': 'RAB geranylgeranylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8876198',\n",
       "   'xref_name': 'RAB GEFs exchange GTP for GDP on RABs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9706019',\n",
       "   'xref_name': 'RHOBTB3 ATPase cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P51151'},\n",
       "  {'component_synonym': 'RAB9A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL240': [{'xref_id': 'R-HSA-1296072',\n",
       "   'xref_name': 'Voltage gated Potassium channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576890',\n",
       "   'xref_name': 'Phase 3 - rapid repolarisation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q12809'},\n",
       "  {'component_synonym': 'KCNH2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2414': [{'xref_id': 'R-HSA-380108',\n",
       "   'xref_name': 'Chemokine receptors bind chemokines.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P51679'},\n",
       "  {'component_synonym': 'CCR4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5014': [{'xref_id': 'R-HSA-168638',\n",
       "   'xref_name': 'NOD1/2 Signaling Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202424',\n",
       "   'xref_name': 'Downstream TCR signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-209543',\n",
       "   'xref_name': 'p75NTR recruits signalling complexes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-445989',\n",
       "   'xref_name': 'TAK1 activates NFkB by phosphorylation and activation of IKKs complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450302',\n",
       "   'xref_name': 'activated TAK1 mediates p38 MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450321',\n",
       "   'xref_name': 'JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689896',\n",
       "   'xref_name': 'Ovarian tumor domain proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9020702',\n",
       "   'xref_name': 'Interleukin-1 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O43353'},\n",
       "  {'component_synonym': 'RIPK2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1983': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P28221'},\n",
       "  {'component_synonym': 'HTR1D', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL210': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689880',\n",
       "   'xref_name': 'Ub-specific processing proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856825',\n",
       "   'xref_name': 'Cargo recognition for clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856828',\n",
       "   'xref_name': 'Clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P07550'},\n",
       "  {'component_synonym': 'ADRB2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5586': [{'xref_id': 'R-HSA-2162123',\n",
       "   'xref_name': 'Synthesis of Prostaglandins (PG) and Thromboxanes (TX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P16152'},\n",
       "  {'component_synonym': 'CBR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2364163': [{'xref_id': 'R-HSA-166665',\n",
       "   'xref_name': 'Terminal pathway of complement.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-174577',\n",
       "   'xref_name': 'Activation of C3 and C5.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-375276',\n",
       "   'xref_name': 'Peptide ligand-binding receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-977606',\n",
       "   'xref_name': 'Regulation of Complement cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P01031'},\n",
       "  {'component_synonym': 'C5', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2327': [{'xref_id': 'R-HSA-380095',\n",
       "   'xref_name': 'Tachykinin receptors bind tachykinins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P21452'},\n",
       "  {'component_synonym': 'TACR2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1075322': [{'xref_id': 'R-HSA-373076',\n",
       "   'xref_name': 'Class A/1 (Rhodopsin-like receptors).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9Y2T6'},\n",
       "  {'component_synonym': 'GPR55', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL205': [{'xref_id': 'R-HSA-1237044',\n",
       "   'xref_name': 'Erythrocytes take up carbon dioxide and release oxygen.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1247673',\n",
       "   'xref_name': 'Erythrocytes take up oxygen and release carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00918'},\n",
       "  {'component_synonym': 'CA2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1962': [{'xref_id': 'R-HSA-1236394',\n",
       "   'xref_name': 'Signaling by ERBB4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-977443',\n",
       "   'xref_name': 'GABA receptor activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P14867'},\n",
       "  {'component_synonym': 'GABRA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL208': [{'xref_id': 'R-HSA-1251985',\n",
       "   'xref_name': 'Nuclear signaling by ERBB4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371497',\n",
       "   'xref_name': 'HSP90 chaperone cycle for steroid hormone receptors (SHR).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018519',\n",
       "   'xref_name': 'Estrogen-dependent gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P06401'},\n",
       "  {'component_synonym': 'PGR', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL261': [{'xref_id': 'R-HSA-1237044',\n",
       "   'xref_name': 'Erythrocytes take up carbon dioxide and release oxygen.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1247673',\n",
       "   'xref_name': 'Erythrocytes take up oxygen and release carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8950505',\n",
       "   'xref_name': 'Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00915'},\n",
       "  {'component_synonym': 'CA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1075163': [{'accession': 'Q8TF76'},\n",
       "  {'component_synonym': 'HASPIN', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL204': [{'xref_id': 'R-HSA-140837',\n",
       "   'xref_name': 'Intrinsic Pathway of Fibrin Clot Formation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-140875',\n",
       "   'xref_name': 'Common Pathway of Fibrin Clot Formation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-159740',\n",
       "   'xref_name': 'Gamma-carboxylation of protein precursors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-159763',\n",
       "   'xref_name': 'Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-159782',\n",
       "   'xref_name': 'Removal of aminoterminal propeptides from gamma-carboxylated proteins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202733',\n",
       "   'xref_name': 'Cell surface interactions at the vascular wall.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-375276',\n",
       "   'xref_name': 'Peptide ligand-binding receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381426',\n",
       "   'xref_name': 'Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-456926',\n",
       "   'xref_name': 'Thrombin signalling through proteinase activated receptors (PARs).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-76009',\n",
       "   'xref_name': 'Platelet Aggregation (Plug Formation).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9657688',\n",
       "   'xref_name': 'Defective factor XII causes hereditary angioedema.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9672391',\n",
       "   'xref_name': 'Defective F8 cleavage by thrombin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-977606',\n",
       "   'xref_name': 'Regulation of Complement cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00734'},\n",
       "  {'component_synonym': 'F2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4204': [{'accession': 'Q9HBH9'},\n",
       "  {'component_synonym': 'MKNK2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL225': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P28335'},\n",
       "  {'component_synonym': 'HTR2C', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1287622': [{'xref_id': 'R-HSA-6804760',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Methylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9Y468'},\n",
       "  {'component_synonym': 'L3MBTL1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1997': [{'xref_id': 'R-HSA-83936',\n",
       "   'xref_name': 'Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q99808'},\n",
       "  {'component_synonym': 'SLC29A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1914': [{'xref_id': 'R-HSA-112311',\n",
       "   'xref_name': 'Neurotransmitter clearance.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1483191',\n",
       "   'xref_name': 'Synthesis of PC.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-422085',\n",
       "   'xref_name': 'Synthesis, secretion, and deacylation of Ghrelin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P06276'},\n",
       "  {'component_synonym': 'BCHE', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2111457': [{'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9Y2D0'},\n",
       "  {'component_synonym': 'CA5B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3596077': [{'xref_id': 'R-HSA-9037629',\n",
       "   'xref_name': 'Lewis blood group biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q11130'},\n",
       "  {'component_synonym': 'FUT7', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2326': [{'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P43166'},\n",
       "  {'component_synonym': 'CA7', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094109': [{'xref_id': 'R-HSA-390648',\n",
       "   'xref_name': 'Muscarinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-399997',\n",
       "   'xref_name': 'Acetylcholine regulates insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20309'},\n",
       "  {'component_synonym': 'CHRM3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3587': [{'xref_id': 'R-HSA-110056',\n",
       "   'xref_name': 'MAPK3 (ERK1) activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-170968',\n",
       "   'xref_name': 'Frs2-mediated activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-445144',\n",
       "   'xref_name': 'Signal transduction by L1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5210891',\n",
       "   'xref_name': 'Uptake and function of anthrax toxins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673000',\n",
       "   'xref_name': 'RAF activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5674135',\n",
       "   'xref_name': 'MAP2K and MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5674499',\n",
       "   'xref_name': 'Negative feedback regulation of MAPK pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5684264',\n",
       "   'xref_name': 'MAP3K8 (TPL2)-dependent MAPK1/3 activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802946',\n",
       "   'xref_name': 'Signaling by moderate kinase activity BRAF mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802948',\n",
       "   'xref_name': 'Signaling by high-kinase activity BRAF mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802952',\n",
       "   'xref_name': 'Signaling by BRAF and RAF fusions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802955',\n",
       "   'xref_name': 'Paradoxical activation of RAF signaling by kinase inactive BRAF.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9649948',\n",
       "   'xref_name': 'Signaling downstream of RAS mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9652169',\n",
       "   'xref_name': 'Signaling by MAP2K mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9656223',\n",
       "   'xref_name': 'Signaling by RAF1 mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q02750'},\n",
       "  {'component_synonym': 'MAP2K1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4096': [{'xref_id': 'R-HSA-111448',\n",
       "   'xref_name': 'Activation of NOXA and translocation to mitochondria.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-139915',\n",
       "   'xref_name': 'Activation of PUMA and translocation to mitochondria.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1912408',\n",
       "   'xref_name': 'Pre-NOTCH Transcription and Translation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559580',\n",
       "   'xref_name': 'Oxidative Stress Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559584',\n",
       "   'xref_name': 'Formation of Senescence-Associated Heterochromatin Foci (SAHF).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559585',\n",
       "   'xref_name': 'Oncogene Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559586',\n",
       "   'xref_name': 'DNA Damage/Telomere Stress Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3232118',\n",
       "   'xref_name': 'SUMOylation of transcription factors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-349425',\n",
       "   'xref_name': 'Autodegradation of the E3 ubiquitin ligase COP1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-390471',\n",
       "   'xref_name': 'Association of TriC/CCT with target proteins during biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5620971',\n",
       "   'xref_name': 'Pyroptosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5628897',\n",
       "   'xref_name': 'TP53 Regulates Metabolic Genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689880',\n",
       "   'xref_name': 'Ub-specific processing proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5689896',\n",
       "   'xref_name': 'Ovarian tumor domain proteases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5693565',\n",
       "   'xref_name': 'Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785807',\n",
       "   'xref_name': 'Interleukin-4 and Interleukin-13 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6796648',\n",
       "   'xref_name': 'TP53 Regulates Transcription of DNA Repair Genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6803204',\n",
       "   'xref_name': 'TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6803205',\n",
       "   'xref_name': 'TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6803207',\n",
       "   'xref_name': 'TP53 Regulates Transcription of Caspase Activators and Caspases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6803211',\n",
       "   'xref_name': 'TP53 Regulates Transcription of Death Receptors and Ligands.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804114',\n",
       "   'xref_name': 'TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804115',\n",
       "   'xref_name': 'TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804116',\n",
       "   'xref_name': 'TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804754',\n",
       "   'xref_name': 'Regulation of TP53 Expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804756',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804757',\n",
       "   'xref_name': 'Regulation of TP53 Degradation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804758',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Acetylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804759',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Association with Co-factors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804760',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Methylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811555',\n",
       "   'xref_name': 'PI5P Regulates TP53 Acetylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69473',\n",
       "   'xref_name': 'G2/M DNA damage checkpoint.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69481',\n",
       "   'xref_name': 'G2/M Checkpoints.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69541',\n",
       "   'xref_name': 'Stabilization of p53.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69895',\n",
       "   'xref_name': 'Transcriptional activation of cell cycle inhibitor p21.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8852276',\n",
       "   'xref_name': 'The role of GTSE1 in G2/M progression after G2 checkpoint.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8853884',\n",
       "   'xref_name': 'Transcriptional Regulation by VENTX.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8941855',\n",
       "   'xref_name': 'RUNX3 regulates CDKN1A transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8943724',\n",
       "   'xref_name': 'Regulation of PTEN gene transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983231',\n",
       "   'xref_name': 'Factors involved in megakaryocyte development and platelet production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P04637'},\n",
       "  {'component_synonym': 'TP53', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL235': [{'xref_id': 'R-HSA-1989781',\n",
       "   'xref_name': 'PPARA activates gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381340',\n",
       "   'xref_name': 'Transcriptional regulation of white adipocyte differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8943724',\n",
       "   'xref_name': 'Regulation of PTEN gene transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022707',\n",
       "   'xref_name': 'MECP2 regulates transcription factors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P37231'},\n",
       "  {'component_synonym': 'PPARG', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5162': [{'xref_id': 'R-HSA-375276',\n",
       "   'xref_name': 'Peptide ligand-binding receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q6W5P4'},\n",
       "  {'component_synonym': 'NPSR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3594': [{'xref_id': 'R-HSA-1234158',\n",
       "   'xref_name': 'Regulation of gene expression by Hypoxia-inducible Factor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q16790'},\n",
       "  {'component_synonym': 'CA9', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293237': [{'xref_id': 'R-HSA-174414',\n",
       "   'xref_name': 'Processive synthesis on the C-strand of the telomere.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3108214',\n",
       "   'xref_name': 'SUMOylation of DNA damage response and repair proteins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5685938',\n",
       "   'xref_name': 'HDR through Single Strand Annealing (SSA).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5685942',\n",
       "   'xref_name': 'HDR through Homologous Recombination (HRR).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5693554',\n",
       "   'xref_name': 'Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5693568',\n",
       "   'xref_name': 'Resolution of D-loop Structures through Holliday Junction Intermediates.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5693579',\n",
       "   'xref_name': 'Homologous DNA Pairing and Strand Exchange.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5693607',\n",
       "   'xref_name': 'Processing of DNA double-strand break ends.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5693616',\n",
       "   'xref_name': 'Presynaptic phase of homologous DNA pairing and strand exchange.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804756',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69473',\n",
       "   'xref_name': 'G2/M DNA damage checkpoint.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-912446',\n",
       "   'xref_name': 'Meiotic recombination.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P54132'},\n",
       "  {'component_synonym': 'BLM', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL223': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416482',\n",
       "   'xref_name': 'G alpha (12/13) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P25100'},\n",
       "  {'component_synonym': 'ADRA1D', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1641347': [{'xref_id': 'R-HSA-561048',\n",
       "   'xref_name': 'Organic anion transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q4U2R8'},\n",
       "  {'component_synonym': 'SLC22A6', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1978': [{'xref_id': 'R-HSA-193144',\n",
       "   'xref_name': 'Estrogen biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211976',\n",
       "   'xref_name': 'Endogenous sterols.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5579030',\n",
       "   'xref_name': 'Defective CYP19A1 causes AEXS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P11511'},\n",
       "  {'component_synonym': 'CYP19A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094125': [{'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q14432'},\n",
       "  {'component_synonym': 'PDE3A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2095173': [{'xref_id': 'R-HSA-936837',\n",
       "   'xref_name': 'Ion transport by P-type ATPases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20648'},\n",
       "  {'component_synonym': 'ATP4A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL202': [{'xref_id': 'R-HSA-1474151',\n",
       "   'xref_name': 'Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-196757',\n",
       "   'xref_name': 'Metabolism of folate and pterines.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69205',\n",
       "   'xref_name': 'G1/S-Specific Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00374'},\n",
       "  {'component_synonym': 'DHFR', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL242': [{'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2219530',\n",
       "   'xref_name': 'Constitutive Signaling by Aberrant PI3K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939211',\n",
       "   'xref_name': 'ESR-mediated signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9009391',\n",
       "   'xref_name': 'Extra-nuclear estrogen signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q92731'},\n",
       "  {'component_synonym': 'ESR2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1899': [{'xref_id': 'R-HSA-112314',\n",
       "   'xref_name': 'Neurotransmitter receptors and postsynaptic signal transmission.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P46098'},\n",
       "  {'component_synonym': 'HTR3A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293236': [{'accession': 'P46063'},\n",
       "  {'component_synonym': 'RECQL', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2095203': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416482',\n",
       "   'xref_name': 'G alpha (12/13) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35348'},\n",
       "  {'component_synonym': 'ADRA1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3251': [{'xref_id': 'R-HSA-1169091',\n",
       "   'xref_name': 'Activation of NF-kappaB in B cells.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1810476',\n",
       "   'xref_name': 'RIP-mediated NFkB activation via ZBP1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193692',\n",
       "   'xref_name': 'Regulated proteolysis of p75NTR.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202424',\n",
       "   'xref_name': 'Downstream TCR signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-209560',\n",
       "   'xref_name': 'NF-kB is activated and signals survival.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559582',\n",
       "   'xref_name': 'Senescence-Associated Secretory Phenotype (SASP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2871837',\n",
       "   'xref_name': 'FCERI mediated NF-kB activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3134963',\n",
       "   'xref_name': 'DEx/H-box helicases activate type I IFN and inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214841',\n",
       "   'xref_name': 'PKMTs methylate histone lysines.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381340',\n",
       "   'xref_name': 'Transcriptional regulation of white adipocyte differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-445989',\n",
       "   'xref_name': 'TAK1 activates NFkB by phosphorylation and activation of IKKs complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-448706',\n",
       "   'xref_name': 'Interleukin-1 processing.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5603029',\n",
       "   'xref_name': 'IkBA variant leads to EDA-ID.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5607764',\n",
       "   'xref_name': 'CLEC7A (Dectin-1) signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5621575',\n",
       "   'xref_name': 'CD209 (DC-SIGN) signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5660668',\n",
       "   'xref_name': 'CLEC7A/inflammasome pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5684264',\n",
       "   'xref_name': 'MAP3K8 (TPL2)-dependent MAPK1/3 activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-844456',\n",
       "   'xref_name': 'The NLRP3 inflammasome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8853884',\n",
       "   'xref_name': 'Transcriptional Regulation by VENTX.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9020702',\n",
       "   'xref_name': 'Interleukin-1 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-933542',\n",
       "   'xref_name': 'TRAF6 mediated NF-kB activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9609690',\n",
       "   'xref_name': 'HCMV Early Events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660826',\n",
       "   'xref_name': 'Purinergic signaling in leishmaniasis infection.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P19838'},\n",
       "  {'component_synonym': 'NFKB1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5843': [{'xref_id': 'R-HSA-5609977',\n",
       "   'xref_name': 'Defective GALE can cause Epimerase-deficiency galactosemia (EDG).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-70370',\n",
       "   'xref_name': 'Galactose catabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q14376'},\n",
       "  {'component_synonym': 'GALE', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4878': [{'xref_id': 'R-HSA-211976',\n",
       "   'xref_name': 'Endogenous sterols.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142670',\n",
       "   'xref_name': 'Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142816',\n",
       "   'xref_name': 'Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5579000',\n",
       "   'xref_name': 'Defective CYP1B1 causes Glaucoma.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q16678'},\n",
       "  {'component_synonym': 'CYP1B1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1833': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P41595'},\n",
       "  {'component_synonym': 'HTR2B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3397': [{'xref_id': 'R-HSA-211981',\n",
       "   'xref_name': 'Xenobiotics.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211999',\n",
       "   'xref_name': 'CYP2E1 reactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142670',\n",
       "   'xref_name': 'Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142816',\n",
       "   'xref_name': 'Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027307',\n",
       "   'xref_name': 'Biosynthesis of maresin-like SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P11712'},\n",
       "  {'component_synonym': 'CYP2C9', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1075189': [{'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-70171',\n",
       "   'xref_name': 'Glycolysis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P14618'},\n",
       "  {'component_synonym': 'PKM', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL260': [{'xref_id': 'R-HSA-168638',\n",
       "   'xref_name': 'NOD1/2 Signaling Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-171007',\n",
       "   'xref_name': 'p38MAPK events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-198753',\n",
       "   'xref_name': 'ERK/MAPK targets.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2151209',\n",
       "   'xref_name': 'Activation of PPARGC1A (PGC-1alpha) by phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559580',\n",
       "   'xref_name': 'Oxidative Stress Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-376172',\n",
       "   'xref_name': 'DSCAM interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418592',\n",
       "   'xref_name': 'ADP signalling through P2Y purinoceptor 1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-432142',\n",
       "   'xref_name': 'Platelet sensitization by LDL.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4420097',\n",
       "   'xref_name': 'VEGFA-VEGFR2 Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450302',\n",
       "   'xref_name': 'activated TAK1 mediates p38 MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450341',\n",
       "   'xref_name': 'Activation of the AP-1 family of transcription factors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450604',\n",
       "   'xref_name': 'KSRP (KHSRP) binds and destabilizes mRNA.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-525793',\n",
       "   'xref_name': 'Myogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5668599',\n",
       "   'xref_name': 'RHO GTPases Activate NADPH Oxidases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804756',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9662834',\n",
       "   'xref_name': 'CD163 mediating an anti-inflammatory response.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q16539'},\n",
       "  {'component_synonym': 'MAPK14', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2265': [{'xref_id': 'R-HSA-2022377',\n",
       "   'xref_name': 'Metabolism of Angiotensinogen to Angiotensins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211945',\n",
       "   'xref_name': 'Phase I - Functionalization of compounds.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P23141'},\n",
       "  {'component_synonym': 'CES1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1907594': [{'xref_id': 'R-HSA-629587',\n",
       "   'xref_name': 'Highly sodium permeable postsynaptic acetylcholine nicotinic receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-629594',\n",
       "   'xref_name': 'Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-629597',\n",
       "   'xref_name': 'Highly calcium permeable nicotinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P30926'},\n",
       "  {'component_synonym': 'CHRNB4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2034': [{'xref_id': 'R-HSA-3371497',\n",
       "   'xref_name': 'HSP90 chaperone cycle for steroid hormone receptors (SHR).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400253',\n",
       "   'xref_name': 'Circadian Clock.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8849473',\n",
       "   'xref_name': 'PTK6 Expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939902',\n",
       "   'xref_name': 'Regulation of RUNX2 expression and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9615017',\n",
       "   'xref_name': 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P04150'},\n",
       "  {'component_synonym': 'NR3C1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL220': [{'xref_id': 'R-HSA-112311',\n",
       "   'xref_name': 'Neurotransmitter clearance.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1483191',\n",
       "   'xref_name': 'Synthesis of PC.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-422085',\n",
       "   'xref_name': 'Synthesis, secretion, and deacylation of Ghrelin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P22303'},\n",
       "  {'component_synonym': 'ACHE', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4331': [{'xref_id': 'R-HSA-1237044',\n",
       "   'xref_name': 'Erythrocytes take up carbon dioxide and release oxygen.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1247673',\n",
       "   'xref_name': 'Erythrocytes take up oxygen and release carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2168880',\n",
       "   'xref_name': 'Scavenging of heme from plasma.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9613829',\n",
       "   'xref_name': 'Chaperone Mediated Autophagy.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9615710',\n",
       "   'xref_name': 'Late endosomal microautophagy.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9707564',\n",
       "   'xref_name': 'Cytoprotection by HMOX1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9707616',\n",
       "   'xref_name': 'Heme signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983231',\n",
       "   'xref_name': 'Factors involved in megakaryocyte development and platelet production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P68871'},\n",
       "  {'component_synonym': 'HBB', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1827': [{'xref_id': 'R-HSA-418457',\n",
       "   'xref_name': 'cGMP effects.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9013422',\n",
       "   'xref_name': 'RHOBTB1 GTPase cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O76074'},\n",
       "  {'component_synonym': 'PDE5A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3026': [{'xref_id': 'R-HSA-977443',\n",
       "   'xref_name': 'GABA receptor activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P34903'},\n",
       "  {'component_synonym': 'GABRA3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3426': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P47898'},\n",
       "  {'component_synonym': 'HTR5A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2104': [{'xref_id': 'R-HSA-139853',\n",
       "   'xref_name': 'Elevation of cytosolic Ca2+ levels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418346',\n",
       "   'xref_name': 'Platelet homeostasis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660826',\n",
       "   'xref_name': 'Purinergic signaling in leishmaniasis infection.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q99571'},\n",
       "  {'component_synonym': 'P2RX4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2095186': [{'xref_id': 'R-HSA-5578775',\n",
       "   'xref_name': 'Ion homeostasis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-936837',\n",
       "   'xref_name': 'Ion transport by P-type ATPases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P05023'},\n",
       "  {'component_synonym': 'ATP1A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1940': [{'xref_id': 'R-HSA-400042',\n",
       "   'xref_name': 'Adrenaline,noradrenaline inhibits insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-419037',\n",
       "   'xref_name': 'NCAM1 interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-422356',\n",
       "   'xref_name': 'Regulation of insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576892',\n",
       "   'xref_name': 'Phase 0 - rapid depolarisation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576893',\n",
       "   'xref_name': 'Phase 2 - plateau phase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13936'},\n",
       "  {'component_synonym': 'CACNA1C', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL264': [{'xref_id': 'R-HSA-390650',\n",
       "   'xref_name': 'Histamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9Y5N1'},\n",
       "  {'component_synonym': 'HRH3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293278': [{'xref_id': 'R-HSA-68827',\n",
       "   'xref_name': 'CDT1 association with the CDC6:ORC:origin complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-68962',\n",
       "   'xref_name': 'Activation of the pre-replicative complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O75496'},\n",
       "  {'component_synonym': 'GMNN', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3242': [{'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O43570'},\n",
       "  {'component_synonym': 'CA12', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL215': [{'xref_id': 'R-HSA-2142688',\n",
       "   'xref_name': 'Synthesis of 5-eicosatetraenoic acids.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142691',\n",
       "   'xref_name': 'Synthesis of Leukotrienes (LT) and Eoxins (EX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142700',\n",
       "   'xref_name': 'Synthesis of Lipoxins (LX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785807',\n",
       "   'xref_name': 'Interleukin-4 and Interleukin-13 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9012546',\n",
       "   'xref_name': 'Interleukin-18 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018676',\n",
       "   'xref_name': 'Biosynthesis of D-series resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018682',\n",
       "   'xref_name': 'Biosynthesis of maresins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018896',\n",
       "   'xref_name': 'Biosynthesis of E-series 18(S)-resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9020265',\n",
       "   'xref_name': 'Biosynthesis of aspirin-triggered D-series resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9023661',\n",
       "   'xref_name': 'Biosynthesis of E-series 18(R)-resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9026286',\n",
       "   'xref_name': 'Biosynthesis of DPAn-3-derived protectins and resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9026290',\n",
       "   'xref_name': 'Biosynthesis of DPAn-3-derived maresins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9026403',\n",
       "   'xref_name': 'Biosynthesis of DPAn-3-derived 13-series resolvins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027604',\n",
       "   'xref_name': 'Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P09917'},\n",
       "  {'component_synonym': 'ALOX5', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4079': [{'xref_id': 'R-HSA-111933',\n",
       "   'xref_name': 'Calmodulin induced events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5635838',\n",
       "   'xref_name': 'Activation of SMO.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856825',\n",
       "   'xref_name': 'Cargo recognition for clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P25098'},\n",
       "  {'component_synonym': 'GRK2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL287': [{'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q99720'},\n",
       "  {'component_synonym': 'SIGMAR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL232': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416482',\n",
       "   'xref_name': 'G alpha (12/13) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35368'},\n",
       "  {'component_synonym': 'ADRA1B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3922': [{'xref_id': 'R-HSA-2514859',\n",
       "   'xref_name': 'Inactivation, recovery and regulation of the phototransduction cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P50579'},\n",
       "  {'component_synonym': 'METAP2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3371': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P50406'},\n",
       "  {'component_synonym': 'HTR6', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5905': [{'xref_id': 'R-HSA-193368',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193775',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 24-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193807',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 27-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-975634',\n",
       "   'xref_name': 'Retinoid metabolism and transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q04828'},\n",
       "  {'component_synonym': 'AKR1C1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293226': [{'accession': 'B2RXH2'},\n",
       "  {'component_synonym': 'KDM4E', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4036': [{'xref_id': 'R-HSA-180024',\n",
       "   'xref_name': 'DARPP-32 events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-399956',\n",
       "   'xref_name': 'CRMPs in Sema3A signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804756',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8862803',\n",
       "   'xref_name': \"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.\",\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9031628',\n",
       "   'xref_name': 'NGF-stimulated transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9032845',\n",
       "   'xref_name': 'Activated NTRK2 signals through CDK5.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983231',\n",
       "   'xref_name': 'Factors involved in megakaryocyte development and platelet production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q00535'},\n",
       "  {'component_synonym': 'CDK5', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1994': [{'xref_id': 'R-HSA-3371497',\n",
       "   'xref_name': 'HSP90 chaperone cycle for steroid hormone receptors (SHR).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08235'},\n",
       "  {'component_synonym': 'NR3C2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3592': [{'xref_id': 'R-HSA-191273',\n",
       "   'xref_name': 'Cholesterol biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2426168',\n",
       "   'xref_name': 'Activation of gene expression by SREBF (SREBP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q14534'},\n",
       "  {'component_synonym': 'SQLE', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094118': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08588'},\n",
       "  {'component_synonym': 'ADRB1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1907588': [{'xref_id': 'R-HSA-629594',\n",
       "   'xref_name': 'Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-629597',\n",
       "   'xref_name': 'Highly calcium permeable nicotinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P02708'},\n",
       "  {'component_synonym': 'CHRNA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4234': [{'xref_id': 'R-HSA-193048',\n",
       "   'xref_name': 'Androgen biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-75876',\n",
       "   'xref_name': 'Synthesis of very long-chain fatty acyl-CoAs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P37058'},\n",
       "  {'component_synonym': 'HSD17B3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1907589': [{'xref_id': 'R-HSA-629587',\n",
       "   'xref_name': 'Highly sodium permeable postsynaptic acetylcholine nicotinic receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-629594',\n",
       "   'xref_name': 'Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-629597',\n",
       "   'xref_name': 'Highly calcium permeable nicotinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P17787'},\n",
       "  {'component_synonym': 'CHRNB2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3623': [{'xref_id': 'R-HSA-350562',\n",
       "   'xref_name': 'Regulation of ornithine decarboxylase (ODC).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P15559'},\n",
       "  {'component_synonym': 'NQO1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2754': [{'xref_id': 'R-HSA-1462054',\n",
       "   'xref_name': 'Alpha-defensins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-167590',\n",
       "   'xref_name': 'Nef Mediated CD4 Down-regulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-173107',\n",
       "   'xref_name': 'Binding and entry of HIV virion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-180534',\n",
       "   'xref_name': 'Vpu mediated degradation of CD4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202424',\n",
       "   'xref_name': 'Downstream TCR signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202427',\n",
       "   'xref_name': 'Phosphorylation of CD3 and TCR zeta chains.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202430',\n",
       "   'xref_name': 'Translocation of ZAP-70 to Immunological synapse.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202433',\n",
       "   'xref_name': 'Generation of second messenger molecules.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-389948',\n",
       "   'xref_name': 'PD-1 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-449836',\n",
       "   'xref_name': 'Other interleukin signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856825',\n",
       "   'xref_name': 'Cargo recognition for clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856828',\n",
       "   'xref_name': 'Clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P01730'},\n",
       "  {'component_synonym': 'CD4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL238': [{'xref_id': 'R-HSA-379401',\n",
       "   'xref_name': 'Dopamine clearance from the synaptic cleft.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-442660',\n",
       "   'xref_name': 'Na+/Cl- dependent neurotransmitter transporters.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5619081',\n",
       "   'xref_name': 'Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5660724',\n",
       "   'xref_name': 'Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q01959'},\n",
       "  {'component_synonym': 'SLC6A3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293232': [{'xref_id': 'R-HSA-191859',\n",
       "   'xref_name': 'snRNP Assembly.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q16637'},\n",
       "  {'component_synonym': 'SMN1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL216': [{'xref_id': 'R-HSA-390648',\n",
       "   'xref_name': 'Muscarinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P11229'},\n",
       "  {'component_synonym': 'CHRM1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3344': [{'xref_id': 'R-HSA-163560',\n",
       "   'xref_name': 'Triglyceride catabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P05413'},\n",
       "  {'component_synonym': 'FABP3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2096670': [{'xref_id': 'R-HSA-399710',\n",
       "   'xref_name': 'Activation of AMPA receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-399719',\n",
       "   'xref_name': 'Trafficking of AMPA receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416993',\n",
       "   'xref_name': 'Trafficking of GluR2-containing AMPA receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-438066',\n",
       "   'xref_name': 'Unblocking of NMDA receptors, glutamate binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8849932',\n",
       "   'xref_name': 'Synaptic adhesion-like molecules.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P48058'},\n",
       "  {'component_synonym': 'GRIA4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5514': [{'xref_id': 'R-HSA-9022692',\n",
       "   'xref_name': 'Regulation of MECP2 expression and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P42858'},\n",
       "  {'component_synonym': 'HTT', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL331': [{'xref_id': 'R-HSA-187577',\n",
       "   'xref_name': 'SCF(Skp2)-mediated degradation of p27/p21.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559580',\n",
       "   'xref_name': 'Oxidative Stress Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559582',\n",
       "   'xref_name': 'Senescence-Associated Secretory Phenotype (SASP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559585',\n",
       "   'xref_name': 'Oncogene Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214858',\n",
       "   'xref_name': 'RMTs methylate histone arginines.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381340',\n",
       "   'xref_name': 'Transcriptional regulation of white adipocyte differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69231',\n",
       "   'xref_name': 'Cyclin D associated events in G1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-75815',\n",
       "   'xref_name': 'Ubiquitin-dependent degradation of Cyclin D.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8849470',\n",
       "   'xref_name': 'PTK6 Regulates Cell Cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8878166',\n",
       "   'xref_name': 'Transcriptional regulation by RUNX2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-912446',\n",
       "   'xref_name': 'Meiotic recombination.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9616222',\n",
       "   'xref_name': 'Transcriptional regulation of granulopoiesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9630791',\n",
       "   'xref_name': 'Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9630794',\n",
       "   'xref_name': 'Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9632697',\n",
       "   'xref_name': 'Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9632700',\n",
       "   'xref_name': 'Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9661069',\n",
       "   'xref_name': 'Defective binding of RB1 mutants to E2F1,(E2F2, E2F3).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P11802'},\n",
       "  {'component_synonym': 'CDK4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL211': [{'xref_id': 'R-HSA-390648',\n",
       "   'xref_name': 'Muscarinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856825',\n",
       "   'xref_name': 'Cargo recognition for clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856828',\n",
       "   'xref_name': 'Clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08172'},\n",
       "  {'component_synonym': 'CHRM2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4611': [{'xref_id': 'R-HSA-166663',\n",
       "   'xref_name': 'Initial triggering of complement.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-173623',\n",
       "   'xref_name': 'Classical antibody-mediated complement activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-977606',\n",
       "   'xref_name': 'Regulation of Complement cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00736'},\n",
       "  {'component_synonym': 'C1R', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4191': [{'xref_id': 'R-HSA-1482883',\n",
       "   'xref_name': 'Acyl chain remodeling of DAG and TAG.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-163560',\n",
       "   'xref_name': 'Triglyceride catabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-426048',\n",
       "   'xref_name': 'Arachidonate production from DAG.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q99685'},\n",
       "  {'component_synonym': 'MGLL', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2722': [{'xref_id': 'R-HSA-193993',\n",
       "   'xref_name': 'Mineralocorticoid biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-194002',\n",
       "   'xref_name': 'Glucocorticoid biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211976',\n",
       "   'xref_name': 'Endogenous sterols.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5579009',\n",
       "   'xref_name': 'Defective CYP11B2 causes CMO-1 deficiency.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P19099'},\n",
       "  {'component_synonym': 'CYP11B2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3305': [{'accession': 'P04278'},\n",
       "  {'component_synonym': 'SHBG', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3356': [{'xref_id': 'R-HSA-156581',\n",
       "   'xref_name': 'Methylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211957',\n",
       "   'xref_name': 'Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142670',\n",
       "   'xref_name': 'Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142816',\n",
       "   'xref_name': 'Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5423646',\n",
       "   'xref_name': 'Aflatoxin activation and detoxification.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018681',\n",
       "   'xref_name': 'Biosynthesis of protectins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027307',\n",
       "   'xref_name': 'Biosynthesis of maresin-like SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P05177'},\n",
       "  {'component_synonym': 'CYP1A2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL203': [{'xref_id': 'R-HSA-1227986',\n",
       "   'xref_name': 'Signaling by ERBB2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1236382',\n",
       "   'xref_name': 'Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1236394',\n",
       "   'xref_name': 'Signaling by ERBB4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1250196',\n",
       "   'xref_name': 'SHC1 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1251932',\n",
       "   'xref_name': 'PLCG1 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-177929',\n",
       "   'xref_name': 'Signaling by EGFR.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-179812',\n",
       "   'xref_name': 'GRB2 events in EGFR signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-180292',\n",
       "   'xref_name': 'GAB1 signalosome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-180336',\n",
       "   'xref_name': 'SHC1 events in EGFR signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-182971',\n",
       "   'xref_name': 'EGFR downregulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1963640',\n",
       "   'xref_name': 'GRB2 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1963642',\n",
       "   'xref_name': 'PI3K events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-212718',\n",
       "   'xref_name': 'EGFR interacts with phospholipase C-gamma.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2179392',\n",
       "   'xref_name': 'EGFR Transactivation by Gastrin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2219530',\n",
       "   'xref_name': 'Constitutive Signaling by Aberrant PI3K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-445144',\n",
       "   'xref_name': 'Signal transduction by L1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5637810',\n",
       "   'xref_name': 'Constitutive Signaling by EGFRvIII.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5638303',\n",
       "   'xref_name': 'Inhibition of Signaling by Overexpressed EGFR.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673001',\n",
       "   'xref_name': 'RAF/MAP kinase cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785631',\n",
       "   'xref_name': 'ERBB2 Regulates Cell Motility.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8847993',\n",
       "   'xref_name': 'ERBB2 Activates PTK6 Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856825',\n",
       "   'xref_name': 'Cargo recognition for clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856828',\n",
       "   'xref_name': 'Clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8857538',\n",
       "   'xref_name': 'PTK6 promotes HIF1A stabilization.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8863795',\n",
       "   'xref_name': 'Downregulation of ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8866910',\n",
       "   'xref_name': 'TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9009391',\n",
       "   'xref_name': 'Extra-nuclear estrogen signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9013507',\n",
       "   'xref_name': 'NOTCH3 Activation and Transmission of Signal to the Nucleus.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9609690',\n",
       "   'xref_name': 'HCMV Early Events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9634638',\n",
       "   'xref_name': 'Estrogen-dependent nuclear events downstream of ESR-membrane signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9664565',\n",
       "   'xref_name': 'Signaling by ERBB2 KD Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665348',\n",
       "   'xref_name': 'Signaling by ERBB2 ECD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665686',\n",
       "   'xref_name': 'Signaling by ERBB2 TMD/JMD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00533'},\n",
       "  {'component_synonym': 'EGFR', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3522': [{'xref_id': 'R-HSA-193048',\n",
       "   'xref_name': 'Androgen biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-194002',\n",
       "   'xref_name': 'Glucocorticoid biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5579028',\n",
       "   'xref_name': 'Defective CYP17A1 causes AH5.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P05093'},\n",
       "  {'component_synonym': 'CYP17A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2885': [{'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P07451'},\n",
       "  {'component_synonym': 'CA3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1949': [{'xref_id': 'R-HSA-114608',\n",
       "   'xref_name': 'Platelet degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-162585',\n",
       "   'xref_name': 'Uncoating of the HIV Virion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-162588',\n",
       "   'xref_name': 'Budding and maturation of HIV virion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-162592',\n",
       "   'xref_name': 'Integration of provirus.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-162594',\n",
       "   'xref_name': 'Early Phase of HIV Life Cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-164516',\n",
       "   'xref_name': 'Minus-strand DNA synthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-164525',\n",
       "   'xref_name': 'Plus-strand DNA synthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-173107',\n",
       "   'xref_name': 'Binding and entry of HIV virion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-175474',\n",
       "   'xref_name': 'Assembly Of The HIV Virion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-180689',\n",
       "   'xref_name': 'APOBEC3G mediated resistance to HIV-1 infection.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2025928',\n",
       "   'xref_name': 'Calcineurin activates NFAT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-210991',\n",
       "   'xref_name': 'Basigin interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8950505',\n",
       "   'xref_name': 'Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P62937'},\n",
       "  {'component_synonym': 'PPIA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2675': [{'xref_id': 'R-HSA-451308',\n",
       "   'xref_name': 'Activation of Ca-permeable Kainate Receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q16478'},\n",
       "  {'component_synonym': 'GRIK5', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3155': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9706019',\n",
       "   'xref_name': 'RHOBTB3 ATPase cycle. [P34969-2]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P34969'},\n",
       "  {'component_synonym': 'HTR7', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4295974': [{'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418597',\n",
       "   'xref_name': 'G alpha (z) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9UGC6'},\n",
       "  {'component_synonym': 'RGS17', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4305': [{'xref_id': 'R-HSA-1296052',\n",
       "   'xref_name': 'Ca2+ activated K+ channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O15554'},\n",
       "  {'component_synonym': 'KCNN4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL256': [{'xref_id': 'R-HSA-417973',\n",
       "   'xref_name': 'Adenosine P1 receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P0DMS8'},\n",
       "  {'component_synonym': 'ADORA3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL224': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P28223'},\n",
       "  {'component_synonym': 'HTR2A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3510': [{'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9ULX7'},\n",
       "  {'component_synonym': 'CA14', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1741189': [{'xref_id': 'R-HSA-1268020',\n",
       "   'xref_name': 'Mitochondrial protein import.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P55789'},\n",
       "  {'component_synonym': 'GFER', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5847': [{'xref_id': 'R-HSA-193368',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193775',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 24-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193807',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 27-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P52895'},\n",
       "  {'component_synonym': 'AKR1C2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL275': [{'xref_id': 'R-HSA-180024',\n",
       "   'xref_name': 'DARPP-32 events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q07343'},\n",
       "  {'component_synonym': 'PDE4B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2998': [{'xref_id': 'R-HSA-139853',\n",
       "   'xref_name': 'Elevation of cytosolic Ca2+ levels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418346',\n",
       "   'xref_name': 'Platelet homeostasis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P56373'},\n",
       "  {'component_synonym': 'P2RX3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2083': [{'xref_id': 'R-HSA-163560',\n",
       "   'xref_name': 'Triglyceride catabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381340',\n",
       "   'xref_name': 'Transcriptional regulation of white adipocyte differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P15090'},\n",
       "  {'component_synonym': 'FABP4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL254': [{'xref_id': 'R-HSA-180024',\n",
       "   'xref_name': 'DARPP-32 events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P27815'},\n",
       "  {'component_synonym': 'PDE4A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3025': [{'xref_id': 'R-HSA-1475029',\n",
       "   'xref_name': 'Reversible hydration of carbon dioxide.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P23280'},\n",
       "  {'component_synonym': 'CA6', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2664': [{'xref_id': 'R-HSA-156581',\n",
       "   'xref_name': 'Methylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1614635',\n",
       "   'xref_name': 'Sulfur amino acid metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2408508',\n",
       "   'xref_name': 'Metabolism of ingested SeMet, Sec, MeSec into H2Se.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5578997',\n",
       "   'xref_name': 'Defective AHCY causes HMAHCHD.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P23526'},\n",
       "  {'component_synonym': 'AHCY', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL289': [{'xref_id': 'R-HSA-211935',\n",
       "   'xref_name': 'Fatty acids.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211958',\n",
       "   'xref_name': 'Miscellaneous substrates.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211981',\n",
       "   'xref_name': 'Xenobiotics.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211999',\n",
       "   'xref_name': 'CYP2E1 reactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027307',\n",
       "   'xref_name': 'Biosynthesis of maresin-like SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P10635'},\n",
       "  {'component_synonym': 'CYP2D6', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2014': [{'xref_id': 'R-HSA-375276',\n",
       "   'xref_name': 'Peptide ligand-binding receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P41146'},\n",
       "  {'component_synonym': 'OPRL1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL6007': [{'xref_id': 'R-HSA-3295583',\n",
       "   'xref_name': 'TRP channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O75762'},\n",
       "  {'component_synonym': 'TRPA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293224': [{'xref_id': 'R-HSA-264870',\n",
       "   'xref_name': 'Caspase-mediated cleavage of cytoskeletal proteins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9619483',\n",
       "   'xref_name': 'Activation of AMPK downstream of NMDARs. [P10636-8]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P10636'},\n",
       "  {'component_synonym': 'MAPT', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL229': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416482',\n",
       "   'xref_name': 'G alpha (12/13) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35348'},\n",
       "  {'component_synonym': 'ADRA1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1860': [{'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors. [P10827-2]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P10827'},\n",
       "  {'component_synonym': 'THRA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1916': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-392023',\n",
       "   'xref_name': 'Adrenaline signalling through Alpha-2 adrenergic receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400042',\n",
       "   'xref_name': 'Adrenaline,noradrenaline inhibits insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418597',\n",
       "   'xref_name': 'G alpha (z) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5683826',\n",
       "   'xref_name': 'Surfactant metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P18825'},\n",
       "  {'component_synonym': 'ADRA2C', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094124': [{'xref_id': 'R-HSA-3928662',\n",
       "   'xref_name': 'EPHB-mediated forward signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-438066',\n",
       "   'xref_name': 'Unblocking of NMDA receptors, glutamate binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-442982',\n",
       "   'xref_name': 'Ras activation upon Ca2+ influx through NMDA receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673001',\n",
       "   'xref_name': 'RAF/MAP kinase cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6794361',\n",
       "   'xref_name': 'Neurexins and neuroligins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8849932',\n",
       "   'xref_name': 'Synaptic adhesion-like molecules.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9609736',\n",
       "   'xref_name': 'Assembly and cell surface presentation of NMDA receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9617324',\n",
       "   'xref_name': 'Negative regulation of NMDA receptor-mediated neuronal transmission.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9620244',\n",
       "   'xref_name': 'Long-term potentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q05586'},\n",
       "  {'component_synonym': 'GRIN1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4429': [{'xref_id': 'R-HSA-380095',\n",
       "   'xref_name': 'Tachykinin receptors bind tachykinins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P29371'},\n",
       "  {'component_synonym': 'TACR3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL6120': [{'xref_id': 'R-HSA-561048',\n",
       "   'xref_name': 'Organic anion transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5619071',\n",
       "   'xref_name': 'Defective SLC22A12 causes renal hypouricemia 1 (RHUC1).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q96S37'},\n",
       "  {'component_synonym': 'SLC22A12', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4355': [{'xref_id': 'R-HSA-432722',\n",
       "   'xref_name': 'Golgi Associated Vesicle Biogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856828',\n",
       "   'xref_name': 'Clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O14976'},\n",
       "  {'component_synonym': 'GAK', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1782': [{'xref_id': 'R-HSA-191273',\n",
       "   'xref_name': 'Cholesterol biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2426168',\n",
       "   'xref_name': 'Activation of gene expression by SREBF (SREBP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P14324'},\n",
       "  {'component_synonym': 'FDPS', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4302': [{'xref_id': 'R-HSA-2161517',\n",
       "   'xref_name': 'Abacavir transmembrane transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-382556',\n",
       "   'xref_name': 'ABC-family proteins mediated transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08183'},\n",
       "  {'component_synonym': 'ABCB1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4729': [{'xref_id': 'R-HSA-211935',\n",
       "   'xref_name': 'Fatty acids.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211981',\n",
       "   'xref_name': 'Xenobiotics.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211999',\n",
       "   'xref_name': 'CYP2E1 reactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20813'},\n",
       "  {'component_synonym': 'CYP2B6', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293256': [{'xref_id': 'R-HSA-76009',\n",
       "   'xref_name': 'Platelet Aggregation (Plug Formation).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P40225'},\n",
       "  {'component_synonym': 'THPO', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3629': [{'xref_id': 'R-HSA-1483191',\n",
       "   'xref_name': 'Synthesis of PC.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-201688',\n",
       "   'xref_name': 'WNT mediated activation of DVL.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2514853',\n",
       "   'xref_name': 'Condensation of Prometaphase Chromosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-445144',\n",
       "   'xref_name': 'Signal transduction by L1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804756',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Phosphorylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6814122',\n",
       "   'xref_name': 'Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8932339',\n",
       "   'xref_name': 'ROS sensing by NFE2L2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8934903',\n",
       "   'xref_name': 'Receptor Mediated Mitophagy.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939243',\n",
       "   'xref_name': 'RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8948751',\n",
       "   'xref_name': 'Regulation of PTEN stability and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P68400'},\n",
       "  {'component_synonym': 'CSNK2A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3622': [{'xref_id': 'R-HSA-211981',\n",
       "   'xref_name': 'Xenobiotics.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211999',\n",
       "   'xref_name': 'CYP2E1 reactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142670',\n",
       "   'xref_name': 'Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142816',\n",
       "   'xref_name': 'Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P33261'},\n",
       "  {'component_synonym': 'CYP2C19', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1937': [{'xref_id': 'R-HSA-193670',\n",
       "   'xref_name': 'p75NTR negatively regulates cell cycle via SC1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2122947',\n",
       "   'xref_name': 'NOTCH1 Intracellular Domain Regulates Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2644606',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2894862',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214815',\n",
       "   'xref_name': 'HDACs deacetylate histones.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-350054',\n",
       "   'xref_name': 'Notch-HLH transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-427389',\n",
       "   'xref_name': 'ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-427413',\n",
       "   'xref_name': 'NoRC negatively regulates rRNA expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4551638',\n",
       "   'xref_name': 'SUMOylation of chromatin organization proteins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804758',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Acetylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73762',\n",
       "   'xref_name': 'RNA Polymerase I Transcription Initiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8943724',\n",
       "   'xref_name': 'Regulation of PTEN gene transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022692',\n",
       "   'xref_name': 'Regulation of MECP2 expression and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022699',\n",
       "   'xref_name': 'MECP2 regulates neuronal receptors and channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9615017',\n",
       "   'xref_name': 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9619665',\n",
       "   'xref_name': 'EGR2 and SOX10-mediated initiation of Schwann cell myelination.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983231',\n",
       "   'xref_name': 'Factors involved in megakaryocyte development and platelet production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q92769'},\n",
       "  {'component_synonym': 'HDAC2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2424': [{'xref_id': 'R-HSA-70268',\n",
       "   'xref_name': 'Pyruvate metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q04760'},\n",
       "  {'component_synonym': 'GLO1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL230': [{'xref_id': 'R-HSA-197264',\n",
       "   'xref_name': 'Nicotinamide salvaging.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142770',\n",
       "   'xref_name': 'Synthesis of 15-eicosatetraenoic acid derivatives.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2162123',\n",
       "   'xref_name': 'Synthesis of Prostaglandins (PG) and Thromboxanes (TX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6783783',\n",
       "   'xref_name': 'Interleukin-10 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785807',\n",
       "   'xref_name': 'Interleukin-4 and Interleukin-13 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018677',\n",
       "   'xref_name': 'Biosynthesis of DHA-derived SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018679',\n",
       "   'xref_name': 'Biosynthesis of EPA-derived SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9025094',\n",
       "   'xref_name': 'Biosynthesis of DPAn-3 SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027604',\n",
       "   'xref_name': 'Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35354'},\n",
       "  {'component_synonym': 'PTGS2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2039': [{'xref_id': 'R-HSA-141333',\n",
       "   'xref_name': 'Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P27338'},\n",
       "  {'component_synonym': 'MAOB', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2097163': [{'accession': 'Q13956'},\n",
       "  {'component_synonym': 'PDE6H', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3437': [{'xref_id': 'R-HSA-211945',\n",
       "   'xref_name': 'Phase I - Functionalization of compounds.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q16853'},\n",
       "  {'component_synonym': 'AOC3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4445': [{'xref_id': 'R-HSA-180024',\n",
       "   'xref_name': 'DARPP-32 events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2025928',\n",
       "   'xref_name': 'Calcineurin activates NFAT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2871809',\n",
       "   'xref_name': 'FCERI mediated Ca+2 mobilization.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4086398',\n",
       "   'xref_name': 'Ca2+ pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5607763',\n",
       "   'xref_name': 'CLEC7A (Dectin-1) induces NFAT activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q08209'},\n",
       "  {'component_synonym': 'PPP3CA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1808': [{'xref_id': 'R-HSA-2022377',\n",
       "   'xref_name': 'Metabolism of Angiotensinogen to Angiotensins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P12821'},\n",
       "  {'component_synonym': 'ACE', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1075138': [{'xref_id': 'R-HSA-5693571',\n",
       "   'xref_name': 'Nonhomologous End-Joining (NHEJ).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9NUW8'},\n",
       "  {'component_synonym': 'TDP1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4040': [{'xref_id': 'R-HSA-111995',\n",
       "   'xref_name': 'phospho-PLA2 pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-112409',\n",
       "   'xref_name': 'RAF-independent MAPK1/3 activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-112411',\n",
       "   'xref_name': 'MAPK1 (ERK2) activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1295596',\n",
       "   'xref_name': 'Spry regulation of FGF signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-162658',\n",
       "   'xref_name': 'Golgi Cisternae Pericentriolar Stack Reorganization.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-170968',\n",
       "   'xref_name': 'Frs2-mediated activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-198753',\n",
       "   'xref_name': 'ERK/MAPK targets.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-202670',\n",
       "   'xref_name': 'ERKs are inactivated.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2029482',\n",
       "   'xref_name': 'Regulation of actin dynamics for phagocytic cup formation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559580',\n",
       "   'xref_name': 'Oxidative Stress Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559582',\n",
       "   'xref_name': 'Senescence-Associated Secretory Phenotype (SASP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2559585',\n",
       "   'xref_name': 'Oncogene Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2871796',\n",
       "   'xref_name': 'FCERI mediated MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371453',\n",
       "   'xref_name': 'Regulation of HSF1-mediated heat shock response.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-375165',\n",
       "   'xref_name': 'NCAM signaling for neurite out-growth.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-437239',\n",
       "   'xref_name': 'Recycling pathway of L1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-444257',\n",
       "   'xref_name': 'RSK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-445144',\n",
       "   'xref_name': 'Signal transduction by L1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450341',\n",
       "   'xref_name': 'Activation of the AP-1 family of transcription factors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-456926',\n",
       "   'xref_name': 'Thrombin signalling through proteinase activated receptors (PARs).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654726',\n",
       "   'xref_name': 'Negative regulation of FGFR1 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654727',\n",
       "   'xref_name': 'Negative regulation of FGFR2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654732',\n",
       "   'xref_name': 'Negative regulation of FGFR3 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654733',\n",
       "   'xref_name': 'Negative regulation of FGFR4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5663213',\n",
       "   'xref_name': 'RHO GTPases Activate WASPs and WAVEs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5668599',\n",
       "   'xref_name': 'RHO GTPases Activate NADPH Oxidases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673001',\n",
       "   'xref_name': 'RAF/MAP kinase cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5674135',\n",
       "   'xref_name': 'MAP2K and MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5674499',\n",
       "   'xref_name': 'Negative feedback regulation of MAPK pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5675221',\n",
       "   'xref_name': 'Negative regulation of MAPK pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802946',\n",
       "   'xref_name': 'Signaling by moderate kinase activity BRAF mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802948',\n",
       "   'xref_name': 'Signaling by high-kinase activity BRAF mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802952',\n",
       "   'xref_name': 'Signaling by BRAF and RAF fusions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802955',\n",
       "   'xref_name': 'Paradoxical activation of RAF signaling by kinase inactive BRAF.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-74749',\n",
       "   'xref_name': 'Signal attenuation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-879415',\n",
       "   'xref_name': 'Advanced glycosylation endproduct receptor signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-881907',\n",
       "   'xref_name': 'Gastrin-CREB signalling pathway via PKC and MAPK.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939211',\n",
       "   'xref_name': 'ESR-mediated signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8940973',\n",
       "   'xref_name': 'RUNX2 regulates osteoblast differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8943724',\n",
       "   'xref_name': 'Regulation of PTEN gene transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9627069',\n",
       "   'xref_name': 'Regulation of the apoptosome activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9634635',\n",
       "   'xref_name': 'Estrogen-stimulated signaling through PRKCZ.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9634638',\n",
       "   'xref_name': 'Estrogen-dependent nuclear events downstream of ESR-membrane signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9635465',\n",
       "   'xref_name': 'Suppression of apoptosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9649948',\n",
       "   'xref_name': 'Signaling downstream of RAS mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9652169',\n",
       "   'xref_name': 'Signaling by MAP2K mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9652817',\n",
       "   'xref_name': 'Signaling by MAPK mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9656223',\n",
       "   'xref_name': 'Signaling by RAF1 mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9664422',\n",
       "   'xref_name': 'FCGR3A-mediated phagocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-982772',\n",
       "   'xref_name': 'Growth hormone receptor signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P28482'},\n",
       "  {'component_synonym': 'MAPK1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4506': [{'xref_id': 'R-HSA-3371453',\n",
       "   'xref_name': 'Regulation of HSF1-mediated heat shock response.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400253',\n",
       "   'xref_name': 'Circadian Clock.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-427359',\n",
       "   'xref_name': 'SIRT1 negatively regulates rRNA expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9617629',\n",
       "   'xref_name': 'Regulation of FOXO transcriptional activity by acetylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9707616',\n",
       "   'xref_name': 'Heme signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q96EB6'},\n",
       "  {'component_synonym': 'SIRT1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1951': [{'xref_id': 'R-HSA-141333',\n",
       "   'xref_name': 'Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-181430',\n",
       "   'xref_name': 'Norepinephrine Neurotransmitter Release Cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-379397',\n",
       "   'xref_name': 'Enzymatic degradation of dopamine by COMT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-379398',\n",
       "   'xref_name': 'Enzymatic degradation of Dopamine by monoamine oxidase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380612',\n",
       "   'xref_name': 'Metabolism of serotonin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5579012',\n",
       "   'xref_name': 'Defective MAOA causes BRUNS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785807',\n",
       "   'xref_name': 'Interleukin-4 and Interleukin-13 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P21397'},\n",
       "  {'component_synonym': 'MAOA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1829': [{'xref_id': 'R-HSA-1368071',\n",
       "   'xref_name': 'NR1D1 (REV-ERBA) represses gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193670',\n",
       "   'xref_name': 'p75NTR negatively regulates cell cycle via SC1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1989781',\n",
       "   'xref_name': 'PPARA activates gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2122947',\n",
       "   'xref_name': 'NOTCH1 Intracellular Domain Regulates Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2151201',\n",
       "   'xref_name': 'Transcriptional activation of mitochondrial biogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2644606',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2894862',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214815',\n",
       "   'xref_name': 'HDACs deacetylate histones.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-350054',\n",
       "   'xref_name': 'Notch-HLH transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381340',\n",
       "   'xref_name': 'Transcriptional regulation of white adipocyte differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-390471',\n",
       "   'xref_name': 'Association of TriC/CCT with target proteins during biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400206',\n",
       "   'xref_name': 'Regulation of lipid metabolism by PPARalpha.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400253',\n",
       "   'xref_name': 'Circadian Clock.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5617472',\n",
       "   'xref_name': 'Activation of anterior HOX genes in hindbrain development during early embryogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8940973',\n",
       "   'xref_name': 'RUNX2 regulates osteoblast differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8943724',\n",
       "   'xref_name': 'Regulation of PTEN gene transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022537',\n",
       "   'xref_name': 'Loss of MECP2 binding ability to the NCoR/SMRT complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022692',\n",
       "   'xref_name': 'Regulation of MECP2 expression and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9029569',\n",
       "   'xref_name': 'NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9609690',\n",
       "   'xref_name': 'HCMV Early Events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9707564',\n",
       "   'xref_name': 'Cytoprotection by HMOX1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9707616',\n",
       "   'xref_name': 'Heme signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O15379'},\n",
       "  {'component_synonym': 'HDAC3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2093863': [{'xref_id': 'R-HSA-180024',\n",
       "   'xref_name': 'DARPP-32 events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P27815'},\n",
       "  {'component_synonym': 'PDE4A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1781': [{'xref_id': 'R-HSA-4615885',\n",
       "   'xref_name': 'SUMOylation of DNA replication proteins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P11387'},\n",
       "  {'component_synonym': 'TOP1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3772': [{'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-420499',\n",
       "   'xref_name': 'Class C/3 (Metabotropic glutamate/pheromone receptors).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6794361',\n",
       "   'xref_name': 'Neurexins and neuroligins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13255'},\n",
       "  {'component_synonym': 'GRM1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL213': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418555',\n",
       "   'xref_name': 'G alpha (s) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9660821',\n",
       "   'xref_name': 'ADORA2B mediated anti-inflammatory cytokines production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08588'},\n",
       "  {'component_synonym': 'ADRB1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4159': [{'xref_id': 'R-HSA-6785470',\n",
       "   'xref_name': 'tRNA processing in the mitochondrion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6787450',\n",
       "   'xref_name': 'tRNA modification in the mitochondrion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-70895',\n",
       "   'xref_name': 'Branched-chain amino acid catabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8868766',\n",
       "   'xref_name': 'rRNA processing in the mitochondrion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q99714'},\n",
       "  {'component_synonym': 'HSD17B10', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5141': [{'xref_id': 'R-HSA-211916',\n",
       "   'xref_name': 'Vitamins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5365859',\n",
       "   'xref_name': 'RA biosynthesis pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O43174'},\n",
       "  {'component_synonym': 'CYP26A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3192': [{'xref_id': 'R-HSA-2122947',\n",
       "   'xref_name': 'NOTCH1 Intracellular Domain Regulates Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2467813',\n",
       "   'xref_name': 'Separation of Sister Chromatids. [Q9BY41-1]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2500257',\n",
       "   'xref_name': 'Resolution of Sister Chromatid Cohesion. [Q9BY41-1]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2644606',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2894862',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214815',\n",
       "   'xref_name': 'HDACs deacetylate histones.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-350054',\n",
       "   'xref_name': 'Notch-HLH transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9BY41'},\n",
       "  {'component_synonym': 'HDAC8', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3009': [{'xref_id': 'R-HSA-1227986',\n",
       "   'xref_name': 'Signaling by ERBB2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1236394',\n",
       "   'xref_name': 'Signaling by ERBB4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1250196',\n",
       "   'xref_name': 'SHC1 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1250342',\n",
       "   'xref_name': 'PI3K events in ERBB4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1250347',\n",
       "   'xref_name': 'SHC1 events in ERBB4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1251985',\n",
       "   'xref_name': 'Nuclear signaling by ERBB4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1253288',\n",
       "   'xref_name': 'Downregulation of ERBB4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1963640',\n",
       "   'xref_name': 'GRB2 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1963642',\n",
       "   'xref_name': 'PI3K events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2219530',\n",
       "   'xref_name': 'Constitutive Signaling by Aberrant PI3K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673001',\n",
       "   'xref_name': 'RAF/MAP kinase cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785631',\n",
       "   'xref_name': 'ERBB2 Regulates Cell Motility.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8847993',\n",
       "   'xref_name': 'ERBB2 Activates PTK6 Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8863795',\n",
       "   'xref_name': 'Downregulation of ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018519',\n",
       "   'xref_name': 'Estrogen-dependent gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9620244',\n",
       "   'xref_name': 'Long-term potentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9664565',\n",
       "   'xref_name': 'Signaling by ERBB2 KD Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665686',\n",
       "   'xref_name': 'Signaling by ERBB2 TMD/JMD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q15303'},\n",
       "  {'component_synonym': 'ERBB4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2637': [{'xref_id': 'R-HSA-2559580',\n",
       "   'xref_name': 'Oxidative Stress Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2871796',\n",
       "   'xref_name': 'FCERI mediated MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450321',\n",
       "   'xref_name': 'JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450341',\n",
       "   'xref_name': 'Activation of the AP-1 family of transcription factors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P53779'},\n",
       "  {'component_synonym': 'MAPK10', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5619': [{'xref_id': 'R-HSA-110357',\n",
       "   'xref_name': 'Displacement of DNA glycosylase by APEX1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-110362',\n",
       "   'xref_name': 'POLB-Dependent Long Patch Base Excision Repair.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-110373',\n",
       "   'xref_name': 'Resolution of AP sites via the multiple-nucleotide patch replacement pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5651801',\n",
       "   'xref_name': 'PCNA-Dependent Long Patch Base Excision Repair.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73930',\n",
       "   'xref_name': 'Abasic sugar-phosphate removal via the single-nucleotide replacement pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73933',\n",
       "   'xref_name': 'Resolution of Abasic Sites (AP sites).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P27695'},\n",
       "  {'component_synonym': 'APEX1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4641': [{'xref_id': 'R-HSA-419037',\n",
       "   'xref_name': 'NCAM1 interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O43497'},\n",
       "  {'component_synonym': 'CACNA1G', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4499': [{'xref_id': 'R-HSA-611105',\n",
       "   'xref_name': 'Respiratory electron transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6799198',\n",
       "   'xref_name': 'Complex I biogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P03905'},\n",
       "  {'component_synonym': 'MT-ND4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5558': [{'xref_id': 'R-HSA-419037',\n",
       "   'xref_name': 'NCAM1 interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9P0X4'},\n",
       "  {'component_synonym': 'CACNA1I', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1075149': [{'xref_id': 'R-HSA-210991',\n",
       "   'xref_name': 'Basigin interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-352230',\n",
       "   'xref_name': 'Amino acid transport across the plasma membrane.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9UPY5'},\n",
       "  {'component_synonym': 'SLC7A11', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094256': [{'xref_id': 'R-HSA-375276',\n",
       "   'xref_name': 'Peptide ligand-binding receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856825',\n",
       "   'xref_name': 'Cargo recognition for clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8856828',\n",
       "   'xref_name': 'Clathrin-mediated endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P30556'},\n",
       "  {'component_synonym': 'AGTR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3880': [{'xref_id': 'R-HSA-1227986',\n",
       "   'xref_name': 'Signaling by ERBB2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1236382',\n",
       "   'xref_name': 'Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1474151',\n",
       "   'xref_name': 'Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168928',\n",
       "   'xref_name': 'DDX58/IFIH1-mediated induction of interferon-alpha/beta.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-192905',\n",
       "   'xref_name': 'vRNP Assembly.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2029482',\n",
       "   'xref_name': 'Regulation of actin dynamics for phagocytic cup formation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-203615',\n",
       "   'xref_name': 'eNOS activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2565942',\n",
       "   'xref_name': 'Regulation of PLK1 Activity at G2/M Transition.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3000484',\n",
       "   'xref_name': 'Scavenging by Class F Receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371497',\n",
       "   'xref_name': 'HSP90 chaperone cycle for steroid hormone receptors (SHR).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371511',\n",
       "   'xref_name': 'HSF1 activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371568',\n",
       "   'xref_name': 'Attenuation phase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371571',\n",
       "   'xref_name': 'HSF1-dependent transactivation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380259',\n",
       "   'xref_name': 'Loss of Nlp from mitotic centrosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380270',\n",
       "   'xref_name': 'Recruitment of mitotic centrosome proteins and complexes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380284',\n",
       "   'xref_name': 'Loss of proteins required for interphase microtubule organization from the centrosome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380320',\n",
       "   'xref_name': 'Recruitment of NuMA to mitotic centrosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-399954',\n",
       "   'xref_name': 'Sema3A PAK dependent Axon repulsion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4420097',\n",
       "   'xref_name': 'VEGFA-VEGFR2 Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5218920',\n",
       "   'xref_name': 'VEGFR2 mediated vascular permeability.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5336415',\n",
       "   'xref_name': 'Uptake and function of diphtheria toxin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5601884',\n",
       "   'xref_name': 'PIWI-interacting RNA (piRNA) biogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5620912',\n",
       "   'xref_name': 'Anchoring of the basal body to the plasma membrane.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5637810',\n",
       "   'xref_name': 'Constitutive Signaling by EGFRvIII.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5675482',\n",
       "   'xref_name': 'Regulation of necroptotic cell death.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785807',\n",
       "   'xref_name': 'Interleukin-4 and Interleukin-13 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8852276',\n",
       "   'xref_name': 'The role of GTSE1 in G2/M progression after G2 checkpoint.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8854518',\n",
       "   'xref_name': 'AURKA Activation by TPX2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8863795',\n",
       "   'xref_name': 'Downregulation of ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939211',\n",
       "   'xref_name': 'ESR-mediated signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9009391',\n",
       "   'xref_name': 'Extra-nuclear estrogen signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9013418',\n",
       "   'xref_name': 'RHOBTB2 GTPase cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018519',\n",
       "   'xref_name': 'Estrogen-dependent gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9613829',\n",
       "   'xref_name': 'Chaperone Mediated Autophagy.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9634285',\n",
       "   'xref_name': 'Constitutive Signaling by Overexpressed ERBB2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9646399',\n",
       "   'xref_name': 'Aggrephagy.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9652282',\n",
       "   'xref_name': 'Drug-mediated inhibition of ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9664565',\n",
       "   'xref_name': 'Signaling by ERBB2 KD Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665233',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to trastuzumab.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665244',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to sapitinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665245',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to tesevatinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665246',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to neratinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665247',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to osimertinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665249',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to afatinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665250',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to AEE788.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665251',\n",
       "   'xref_name': 'Resistance of ERBB2 KD mutants to lapatinib.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665348',\n",
       "   'xref_name': 'Signaling by ERBB2 ECD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665686',\n",
       "   'xref_name': 'Signaling by ERBB2 TMD/JMD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665737',\n",
       "   'xref_name': 'Drug resistance in ERBB2 TMD/JMD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P07900'},\n",
       "  {'component_synonym': 'HSP90AA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3759': [{'xref_id': 'R-HSA-390650',\n",
       "   'xref_name': 'Histamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9H3N8'},\n",
       "  {'component_synonym': 'HRH4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4398': [{'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-417957',\n",
       "   'xref_name': 'P2Y receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5683826',\n",
       "   'xref_name': 'Surfactant metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P41231'},\n",
       "  {'component_synonym': 'P2RY2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4235': [{'xref_id': 'R-HSA-194002',\n",
       "   'xref_name': 'Glucocorticoid biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P28845'},\n",
       "  {'component_synonym': 'HSD11B1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL234': [{'xref_id': 'R-HSA-390651',\n",
       "   'xref_name': 'Dopamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35462'},\n",
       "  {'component_synonym': 'DRD3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2061': [{'xref_id': 'R-HSA-1368082',\n",
       "   'xref_name': 'RORA activates gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1368108',\n",
       "   'xref_name': 'BMAL1:CLOCK,NPAS2 activates circadian gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-159418',\n",
       "   'xref_name': 'Recycling of bile acids and salts.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-192105',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193368',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193807',\n",
       "   'xref_name': 'Synthesis of bile acids and bile salts via 27-hydroxycholesterol.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1989781',\n",
       "   'xref_name': 'PPARA activates gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-200425',\n",
       "   'xref_name': 'Carnitine metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-204174',\n",
       "   'xref_name': 'Regulation of pyruvate dehydrogenase (PDH) complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-211976',\n",
       "   'xref_name': 'Endogenous sterols.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2151201',\n",
       "   'xref_name': 'Transcriptional activation of mitochondrial biogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2426168',\n",
       "   'xref_name': 'Activation of gene expression by SREBF (SREBP).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-381340',\n",
       "   'xref_name': 'Transcriptional regulation of white adipocyte differentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400206',\n",
       "   'xref_name': 'Regulation of lipid metabolism by PPARalpha.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-400253',\n",
       "   'xref_name': 'Circadian Clock.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5362517',\n",
       "   'xref_name': 'Signaling by Retinoic Acid.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5617472',\n",
       "   'xref_name': 'Activation of anterior HOX genes in hindbrain development during early embryogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9029558',\n",
       "   'xref_name': 'NR1H2 & NR1H3 regulate gene expression linked to lipogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9029569',\n",
       "   'xref_name': 'NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9031525',\n",
       "   'xref_name': 'NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9031528',\n",
       "   'xref_name': 'NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9616222',\n",
       "   'xref_name': 'Transcriptional regulation of granulopoiesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9623433',\n",
       "   'xref_name': 'NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9632974',\n",
       "   'xref_name': 'NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9707564',\n",
       "   'xref_name': 'Cytoprotection by HMOX1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9707616',\n",
       "   'xref_name': 'Heme signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P19793'},\n",
       "  {'component_synonym': 'RXRA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1821': [{'xref_id': 'R-HSA-390648',\n",
       "   'xref_name': 'Muscarinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08173'},\n",
       "  {'component_synonym': 'CHRM4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2093866': [{'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2219530',\n",
       "   'xref_name': 'Constitutive Signaling by Aberrant PI3K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939211',\n",
       "   'xref_name': 'ESR-mediated signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9009391',\n",
       "   'xref_name': 'Extra-nuclear estrogen signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q92731'},\n",
       "  {'component_synonym': 'ESR2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL231': [{'xref_id': 'R-HSA-390650',\n",
       "   'xref_name': 'Histamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35367'},\n",
       "  {'component_synonym': 'HRH1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094': [{'xref_id': 'R-HSA-139853',\n",
       "   'xref_name': 'Elevation of cytosolic Ca2+ levels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418346',\n",
       "   'xref_name': 'Platelet homeostasis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P51575'},\n",
       "  {'component_synonym': 'P2RX1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4179': [{'xref_id': 'R-HSA-2559580',\n",
       "   'xref_name': 'Oxidative Stress Induced Senescence.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2871796',\n",
       "   'xref_name': 'FCERI mediated MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450321',\n",
       "   'xref_name': 'JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-450341',\n",
       "   'xref_name': 'Activation of the AP-1 family of transcription factors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P45984'},\n",
       "  {'component_synonym': 'MAPK9', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1293299': [{'xref_id': 'R-HSA-3214841',\n",
       "   'xref_name': 'PKMTs methylate histone lysines.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8936459',\n",
       "   'xref_name': 'RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8939236',\n",
       "   'xref_name': 'RUNX1 regulates transcription of genes involved in differentiation of HSCs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9616222',\n",
       "   'xref_name': 'Transcriptional regulation of granulopoiesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q03164'},\n",
       "  {'component_synonym': 'KMT2A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL279': [{'xref_id': 'R-HSA-194306',\n",
       "   'xref_name': 'Neurophilin interactions with VEGF and VEGFR.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-195399',\n",
       "   'xref_name': 'VEGF binds to VEGFR leading to receptor dimerization.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-216083',\n",
       "   'xref_name': 'Integrin cell surface interactions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4420097',\n",
       "   'xref_name': 'VEGFA-VEGFR2 Pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5218921',\n",
       "   'xref_name': 'VEGFR2 mediated cell proliferation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9673768',\n",
       "   'xref_name': 'Signaling by membrane-tethered fusions of PDGFRA or PDGFRB.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35968'},\n",
       "  {'component_synonym': 'KDR', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL222': [{'xref_id': 'R-HSA-442660',\n",
       "   'xref_name': 'Na+/Cl- dependent neurotransmitter transporters.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5619109',\n",
       "   'xref_name': 'Defective SLC6A2 causes orthostatic intolerance (OI).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P23975'},\n",
       "  {'component_synonym': 'SLC6A2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2093865': [{'xref_id': 'R-HSA-1362277',\n",
       "   'xref_name': 'Transcription of E2F targets under negative control by DREAM complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1362300',\n",
       "   'xref_name': 'Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1538133',\n",
       "   'xref_name': 'G0 and Early G1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-193670',\n",
       "   'xref_name': 'p75NTR negatively regulates cell cycle via SC1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-201722',\n",
       "   'xref_name': 'Formation of the beta-catenin:TCF transactivating complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2122947',\n",
       "   'xref_name': 'NOTCH1 Intracellular Domain Regulates Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2173795',\n",
       "   'xref_name': 'Downregulation of SMAD2/3:SMAD4 transcriptional activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2173796',\n",
       "   'xref_name': 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2644606',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2894862',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3214815',\n",
       "   'xref_name': 'HDACs deacetylate histones.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-350054',\n",
       "   'xref_name': 'Notch-HLH transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3769402',\n",
       "   'xref_name': 'Deactivation of the beta-catenin transactivating complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-427389',\n",
       "   'xref_name': 'ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-427413',\n",
       "   'xref_name': 'NoRC negatively regulates rRNA expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4551638',\n",
       "   'xref_name': 'SUMOylation of chromatin organization proteins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4641265',\n",
       "   'xref_name': 'Repression of WNT target genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6804758',\n",
       "   'xref_name': 'Regulation of TP53 Activity through Acetylation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69205',\n",
       "   'xref_name': 'G1/S-Specific Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73762',\n",
       "   'xref_name': 'RNA Polymerase I Transcription Initiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8936459',\n",
       "   'xref_name': 'RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8943724',\n",
       "   'xref_name': 'Regulation of PTEN gene transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018519',\n",
       "   'xref_name': 'Estrogen-dependent gene expression.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022538',\n",
       "   'xref_name': 'Loss of MECP2 binding ability to 5mC-DNA.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022692',\n",
       "   'xref_name': 'Regulation of MECP2 expression and activity.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022699',\n",
       "   'xref_name': 'MECP2 regulates neuronal receptors and channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022702',\n",
       "   'xref_name': 'MECP2 regulates transcription of neuronal ligands.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9615017',\n",
       "   'xref_name': 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983231',\n",
       "   'xref_name': 'Factors involved in megakaryocyte development and platelet production.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13547'},\n",
       "  {'component_synonym': 'HDAC1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2111462': [{'xref_id': 'R-HSA-383280',\n",
       "   'xref_name': 'Nuclear Receptor transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-4090294',\n",
       "   'xref_name': 'SUMOylation of intracellular receptors. [P10827-2]',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P10827'},\n",
       "  {'component_synonym': 'THRA', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2311224': [{'accession': 'P0AES6'},\n",
       "  {'component_synonym': 'gyrB', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2362972': [{'accession': 'P72355'},\n",
       "  {'component_synonym': 'pbp4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2096972': [{'xref_id': 'R-HSA-1296025',\n",
       "   'xref_name': 'ATP sensitive Potassium channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-382556',\n",
       "   'xref_name': 'ABC-family proteins mediated transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-422356',\n",
       "   'xref_name': 'Regulation of insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5578775',\n",
       "   'xref_name': 'Ion homeostasis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5678420',\n",
       "   'xref_name': 'Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5683177',\n",
       "   'xref_name': 'Defective ABCC8 can cause hypo- and hyper-glycemias.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q14654'},\n",
       "  {'component_synonym': 'KCNJ11', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2363064': [{'xref_id': 'R-HSA-380615',\n",
       "   'xref_name': 'Serotonin clearance from the synaptic cleft.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P31645'},\n",
       "  {'component_synonym': 'SLC6A4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3310': [{'xref_id': 'R-HSA-2122947',\n",
       "   'xref_name': 'NOTCH1 Intracellular Domain Regulates Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2644606',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2894862',\n",
       "   'xref_name': 'Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-350054',\n",
       "   'xref_name': 'Notch-HLH transcription pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q96DB2'},\n",
       "  {'component_synonym': 'HDAC11', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2821': [{'xref_id': 'R-HSA-140837',\n",
       "   'xref_name': 'Intrinsic Pathway of Fibrin Clot Formation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9657688',\n",
       "   'xref_name': 'Defective factor XII causes hereditary angioedema.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9657689',\n",
       "   'xref_name': 'Defective SERPING1 causes hereditary angioedema.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P00748'},\n",
       "  {'component_synonym': 'F12', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2364675': [{'xref_id': 'R-HSA-211981',\n",
       "   'xref_name': 'Xenobiotics.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5423646',\n",
       "   'xref_name': 'Aflatoxin activation and detoxification.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027307',\n",
       "   'xref_name': 'Biosynthesis of maresin-like SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P08684'},\n",
       "  {'component_synonym': 'CYP3A4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5375': [{'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q8JXU8'},\n",
       "  {'component_synonym': 'NS5B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2362989': [{'accession': 'Q969P6'},\n",
       "  {'component_synonym': 'TOP1MT', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2095200': [{'xref_id': 'R-HSA-390666',\n",
       "   'xref_name': 'Serotonin receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P41595'},\n",
       "  {'component_synonym': 'HTR2B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1874': [{'xref_id': 'R-HSA-426117',\n",
       "   'xref_name': 'Cation-coupled Chloride cotransporters.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5619104',\n",
       "   'xref_name': 'Defective SLC12A1 causes Bartter syndrome 1 (BS1).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q13621'},\n",
       "  {'component_synonym': 'SLC12A1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2363076': [{'accession': 'P0AFI2'},\n",
       "  {'component_synonym': 'parC', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2331043': [{'xref_id': 'R-HSA-445095',\n",
       "   'xref_name': 'Interaction between L1 and Ankyrins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576892',\n",
       "   'xref_name': 'Phase 0 - rapid depolarisation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35498'},\n",
       "  {'component_synonym': 'SCN1A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1886': [{'xref_id': 'R-HSA-1296025',\n",
       "   'xref_name': 'ATP sensitive Potassium channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-382556',\n",
       "   'xref_name': 'ABC-family proteins mediated transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-422356',\n",
       "   'xref_name': 'Regulation of insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5578775',\n",
       "   'xref_name': 'Ion homeostasis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5678420',\n",
       "   'xref_name': 'Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5683177',\n",
       "   'xref_name': 'Defective ABCC8 can cause hypo- and hyper-glycemias.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q14654'},\n",
       "  {'component_synonym': 'KCNJ11', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2363066': [{'xref_id': 'R-HSA-418457',\n",
       "   'xref_name': 'cGMP effects.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9013422',\n",
       "   'xref_name': 'RHOBTB1 GTPase cycle.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'O76074'},\n",
       "  {'component_synonym': 'PDE5A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL218': [{'xref_id': 'R-HSA-373076',\n",
       "   'xref_name': 'Class A/1 (Rhodopsin-like receptors).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P21554'},\n",
       "  {'component_synonym': 'CNR1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2354204': [{'accession': 'P24228'},\n",
       "  {'component_synonym': 'dacB', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2094253': [{'xref_id': 'R-HSA-197264',\n",
       "   'xref_name': 'Nicotinamide salvaging.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2142770',\n",
       "   'xref_name': 'Synthesis of 15-eicosatetraenoic acid derivatives.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2162123',\n",
       "   'xref_name': 'Synthesis of Prostaglandins (PG) and Thromboxanes (TX).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6783783',\n",
       "   'xref_name': 'Interleukin-10 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6785807',\n",
       "   'xref_name': 'Interleukin-4 and Interleukin-13 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018677',\n",
       "   'xref_name': 'Biosynthesis of DHA-derived SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9018679',\n",
       "   'xref_name': 'Biosynthesis of EPA-derived SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9025094',\n",
       "   'xref_name': 'Biosynthesis of DPAn-3 SPMs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027604',\n",
       "   'xref_name': 'Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35354'},\n",
       "  {'component_synonym': 'PTGS2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL3391661': [{'xref_id': 'R-HSA-1614635',\n",
       "   'xref_name': 'Sulfur amino acid metabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798163',\n",
       "   'xref_name': 'Choline catabolism.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q93088'},\n",
       "  {'component_synonym': 'BHMT', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2362992': [{'xref_id': 'R-HSA-73817',\n",
       "   'xref_name': 'Purine ribonucleoside monophosphate biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q06203'},\n",
       "  {'component_synonym': 'PPAT', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2311225': [{'accession': 'P0A4L9'},\n",
       "  {'component_synonym': 'gyrB', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL5216': [{'xref_id': 'R-HSA-500753',\n",
       "   'xref_name': 'Pyrimidine biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P11172'},\n",
       "  {'component_synonym': 'UMPS', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1839': [{'xref_id': 'R-HSA-209968',\n",
       "   'xref_name': 'Thyroxine biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P07202'},\n",
       "  {'component_synonym': 'TPO', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1932894': [{'xref_id': 'R-HSA-168255',\n",
       "   'xref_name': 'Influenza Infection.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168275',\n",
       "   'xref_name': 'Entry of Influenza Virion into Host Cell via Endocytosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168288',\n",
       "   'xref_name': 'Fusion of the Influenza Virion to the Host Cell Endosome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168298',\n",
       "   'xref_name': 'Release.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168302',\n",
       "   'xref_name': 'Budding.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168303',\n",
       "   'xref_name': 'Packaging of Eight RNA Segments.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168316',\n",
       "   'xref_name': 'Assembly of Viral Components at the Budding Site.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168336',\n",
       "   'xref_name': 'Uncoating of the Influenza Virion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-168874',\n",
       "   'xref_name': 'Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-192823',\n",
       "   'xref_name': 'Viral mRNA Translation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P06821'},\n",
       "  {'component_synonym': 'M', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4770': [{'xref_id': 'R-HSA-1296025',\n",
       "   'xref_name': 'ATP sensitive Potassium channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q15842'},\n",
       "  {'component_synonym': 'KCNJ8', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2364668': [{'accession': 'P0AC13'},\n",
       "  {'component_synonym': 'folP', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2362988': [{'accession': 'A2PZ98'},\n",
       "  {'component_synonym': 'Ace1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2362996': [{'xref_id': 'R-HSA-1296072',\n",
       "   'xref_name': 'Voltage gated Potassium channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576893',\n",
       "   'xref_name': 'Phase 2 - plateau phase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5576890',\n",
       "   'xref_name': 'Phase 3 - rapid repolarisation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P51787'},\n",
       "  {'component_synonym': 'KCNQ1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL243': [{'accession': 'Q72874'},\n",
       "  {'component_synonym': 'pol', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1876': [{'xref_id': 'R-HSA-426117',\n",
       "   'xref_name': 'Cation-coupled Chloride cotransporters.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5619087',\n",
       "   'xref_name': 'Defective SLC12A3 causes Gitelman syndrome (GS).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P55017'},\n",
       "  {'component_synonym': 'SLC12A3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1930': [{'xref_id': 'R-HSA-6806664',\n",
       "   'xref_name': 'Metabolism of vitamin K.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q9BQB6'},\n",
       "  {'component_synonym': 'VKORC1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL247': [{'accession': 'Q72547'},\n",
       "  {'component_synonym': 'pol', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2111369': [{'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-73817',\n",
       "   'xref_name': 'Purine ribonucleoside monophosphate biosynthesis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9679191',\n",
       "   'xref_name': 'Potential therapeutics for SARS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20839'},\n",
       "  {'component_synonym': 'IMPDH1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2362997': [{'xref_id': 'R-HSA-629594',\n",
       "   'xref_name': 'Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-629597',\n",
       "   'xref_name': 'Highly calcium permeable nicotinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P02708'},\n",
       "  {'component_synonym': 'CHRNA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1972': [{'xref_id': 'R-HSA-438066',\n",
       "   'xref_name': 'Unblocking of NMDA receptors, glutamate binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6794361',\n",
       "   'xref_name': 'Neurexins and neuroligins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8849932',\n",
       "   'xref_name': 'Synaptic adhesion-like molecules.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9022699',\n",
       "   'xref_name': 'MECP2 regulates neuronal receptors and channels.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9609736',\n",
       "   'xref_name': 'Assembly and cell surface presentation of NMDA receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9617324',\n",
       "   'xref_name': 'Negative regulation of NMDA receptor-mediated neuronal transmission.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9620244',\n",
       "   'xref_name': 'Long-term potentiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'Q12879'},\n",
       "  {'component_synonym': 'GRIN2A', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2363135': [{'accession': 'P0A7V0'},\n",
       "  {'component_synonym': 'rpsB', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2331075': [{'xref_id': 'R-HSA-390651',\n",
       "   'xref_name': 'Dopamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P14416'},\n",
       "  {'component_synonym': 'DRD2', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2364678': [{'accession': 'P0AEK4'},\n",
       "  {'component_synonym': 'fabI', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2111329': [{'xref_id': 'R-HSA-417973',\n",
       "   'xref_name': 'Adenosine P1 receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P30542'},\n",
       "  {'component_synonym': 'ADORA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2363042': [{'xref_id': 'R-HSA-113501',\n",
       "   'xref_name': 'Inhibition of replication initiation of damaged DNA by RB1/E2F1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-174411',\n",
       "   'xref_name': 'Polymerase switching on the C-strand of the telomere.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-174430',\n",
       "   'xref_name': 'Telomere C-strand synthesis initiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-68952',\n",
       "   'xref_name': 'DNA replication initiation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-68962',\n",
       "   'xref_name': 'Activation of the pre-replicative complex.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69091',\n",
       "   'xref_name': 'Polymerase switching.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69166',\n",
       "   'xref_name': 'Removal of the Flap Intermediate.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69183',\n",
       "   'xref_name': 'Processive synthesis on the lagging strand.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69205',\n",
       "   'xref_name': 'G1/S-Specific Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9710421',\n",
       "   'xref_name': 'Defective pyroptosis.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P09884'},\n",
       "  {'component_synonym': 'POLA1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2363033': [{'accession': 'P72525'},\n",
       "  {'component_synonym': 'parC', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2120': [{'xref_id': 'R-HSA-109704',\n",
       "   'xref_name': 'PI3K Cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1257604',\n",
       "   'xref_name': 'PIP3 activates AKT signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1839122',\n",
       "   'xref_name': 'Signaling by activated point mutants of FGFR1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1839130',\n",
       "   'xref_name': 'Signaling by activated point mutants of FGFR3.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190322',\n",
       "   'xref_name': 'FGFR4 ligand binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190370',\n",
       "   'xref_name': 'FGFR1b ligand binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190371',\n",
       "   'xref_name': 'FGFR3b ligand binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190372',\n",
       "   'xref_name': 'FGFR3c ligand binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190373',\n",
       "   'xref_name': 'FGFR1c ligand binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190375',\n",
       "   'xref_name': 'FGFR2c ligand binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190377',\n",
       "   'xref_name': 'FGFR2b ligand binding and activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2033514',\n",
       "   'xref_name': 'FGFR3 mutant receptor activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2033519',\n",
       "   'xref_name': 'Activated point mutants of FGFR2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2219530',\n",
       "   'xref_name': 'Constitutive Signaling by Aberrant PI3K in Cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654219',\n",
       "   'xref_name': 'Phospholipase C-mediated cascade: FGFR1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654221',\n",
       "   'xref_name': 'Phospholipase C-mediated cascade, FGFR2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654227',\n",
       "   'xref_name': 'Phospholipase C-mediated cascade, FGFR3.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654228',\n",
       "   'xref_name': 'Phospholipase C-mediated cascade, FGFR4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654687',\n",
       "   'xref_name': 'Downstream signaling of activated FGFR1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654688',\n",
       "   'xref_name': 'SHC-mediated cascade:FGFR1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654689',\n",
       "   'xref_name': 'PI-3K cascade:FGFR1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654693',\n",
       "   'xref_name': 'FRS-mediated FGFR1 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654695',\n",
       "   'xref_name': 'PI-3K cascade:FGFR2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654699',\n",
       "   'xref_name': 'SHC-mediated cascade:FGFR2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654700',\n",
       "   'xref_name': 'FRS-mediated FGFR2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654704',\n",
       "   'xref_name': 'SHC-mediated cascade:FGFR3.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654706',\n",
       "   'xref_name': 'FRS-mediated FGFR3 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654710',\n",
       "   'xref_name': 'PI-3K cascade:FGFR3.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654712',\n",
       "   'xref_name': 'FRS-mediated FGFR4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654719',\n",
       "   'xref_name': 'SHC-mediated cascade:FGFR4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654720',\n",
       "   'xref_name': 'PI-3K cascade:FGFR4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654726',\n",
       "   'xref_name': 'Negative regulation of FGFR1 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654727',\n",
       "   'xref_name': 'Negative regulation of FGFR2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654732',\n",
       "   'xref_name': 'Negative regulation of FGFR3 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654733',\n",
       "   'xref_name': 'Negative regulation of FGFR4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5655253',\n",
       "   'xref_name': 'Signaling by FGFR2 in disease.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5655302',\n",
       "   'xref_name': 'Signaling by FGFR1 in disease.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673001',\n",
       "   'xref_name': 'RAF/MAP kinase cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811558',\n",
       "   'xref_name': 'PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8851708',\n",
       "   'xref_name': 'Signaling by FGFR2 IIIa TM.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8853338',\n",
       "   'xref_name': 'Signaling by FGFR3 point mutants in cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P05230'},\n",
       "  {'component_synonym': 'FGF1', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL4524006': [{'xref_id': 'R-HSA-112412',\n",
       "   'xref_name': 'SOS-mediated signalling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1169092',\n",
       "   'xref_name': 'Activation of RAS in B cells.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1236382',\n",
       "   'xref_name': 'Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1250196',\n",
       "   'xref_name': 'SHC1 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1250347',\n",
       "   'xref_name': 'SHC1 events in ERBB4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1433557',\n",
       "   'xref_name': 'Signaling by SCF-KIT.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-167044',\n",
       "   'xref_name': 'Signalling to RAS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-171007',\n",
       "   'xref_name': 'p38MAPK events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-179812',\n",
       "   'xref_name': 'GRB2 events in EGFR signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-180336',\n",
       "   'xref_name': 'SHC1 events in EGFR signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-186763',\n",
       "   'xref_name': 'Downstream signal transduction.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-1963640',\n",
       "   'xref_name': 'GRB2 events in ERBB2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-210993',\n",
       "   'xref_name': 'Tie2 Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2179392',\n",
       "   'xref_name': 'EGFR Transactivation by Gastrin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2424491',\n",
       "   'xref_name': 'DAP12 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2428933',\n",
       "   'xref_name': 'SHC-related events triggered by IGF1R.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2871796',\n",
       "   'xref_name': 'FCERI mediated MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-375165',\n",
       "   'xref_name': 'NCAM signaling for neurite out-growth.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3928662',\n",
       "   'xref_name': 'EPHB-mediated forward signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-442982',\n",
       "   'xref_name': 'Ras activation upon Ca2+ influx through NMDA receptor.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5218921',\n",
       "   'xref_name': 'VEGFR2 mediated cell proliferation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5621575',\n",
       "   'xref_name': 'CD209 (DC-SIGN) signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5637810',\n",
       "   'xref_name': 'Constitutive Signaling by EGFRvIII.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654688',\n",
       "   'xref_name': 'SHC-mediated cascade:FGFR1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654693',\n",
       "   'xref_name': 'FRS-mediated FGFR1 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654699',\n",
       "   'xref_name': 'SHC-mediated cascade:FGFR2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654700',\n",
       "   'xref_name': 'FRS-mediated FGFR2 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654704',\n",
       "   'xref_name': 'SHC-mediated cascade:FGFR3.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654706',\n",
       "   'xref_name': 'FRS-mediated FGFR3 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654712',\n",
       "   'xref_name': 'FRS-mediated FGFR4 signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5654719',\n",
       "   'xref_name': 'SHC-mediated cascade:FGFR4.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5655253',\n",
       "   'xref_name': 'Signaling by FGFR2 in disease.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5655291',\n",
       "   'xref_name': 'Signaling by FGFR4 in disease.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5655302',\n",
       "   'xref_name': 'Signaling by FGFR1 in disease.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5658442',\n",
       "   'xref_name': 'Regulation of RAS by GAPs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673000',\n",
       "   'xref_name': 'RAF activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5673001',\n",
       "   'xref_name': 'RAF/MAP kinase cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5674135',\n",
       "   'xref_name': 'MAP2K and MAPK activation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5675221',\n",
       "   'xref_name': 'Negative regulation of MAPK pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802946',\n",
       "   'xref_name': 'Signaling by moderate kinase activity BRAF mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802948',\n",
       "   'xref_name': 'Signaling by high-kinase activity BRAF mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802952',\n",
       "   'xref_name': 'Signaling by BRAF and RAF fusions.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802953',\n",
       "   'xref_name': 'RAS signaling downstream of NF1 loss-of-function variants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6802955',\n",
       "   'xref_name': 'Paradoxical activation of RAF signaling by kinase inactive BRAF.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-74751',\n",
       "   'xref_name': 'Insulin receptor signalling cascade.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8849471',\n",
       "   'xref_name': 'PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8851805',\n",
       "   'xref_name': 'MET activates RAS signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8853334',\n",
       "   'xref_name': 'Signaling by FGFR3 fusions in cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8853338',\n",
       "   'xref_name': 'Signaling by FGFR3 point mutants in cancer.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9026519',\n",
       "   'xref_name': 'Activated NTRK2 signals through RAS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9027284',\n",
       "   'xref_name': 'Erythropoietin activates RAS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9028731',\n",
       "   'xref_name': 'Activated NTRK2 signals through FRS2 and FRS3.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9034864',\n",
       "   'xref_name': 'Activated NTRK3 signals through RAS.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9607240',\n",
       "   'xref_name': 'FLT3 Signaling.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9634285',\n",
       "   'xref_name': 'Constitutive Signaling by Overexpressed ERBB2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9634635',\n",
       "   'xref_name': 'Estrogen-stimulated signaling through PRKCZ.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9648002',\n",
       "   'xref_name': 'RAS processing.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9649913',\n",
       "   'xref_name': 'RAS GTPase cycle mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9649948',\n",
       "   'xref_name': 'Signaling downstream of RAS mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9656223',\n",
       "   'xref_name': 'Signaling by RAF1 mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9664565',\n",
       "   'xref_name': 'Signaling by ERBB2 KD Mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665348',\n",
       "   'xref_name': 'Signaling by ERBB2 ECD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9665686',\n",
       "   'xref_name': 'Signaling by ERBB2 TMD/JMD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9670439',\n",
       "   'xref_name': 'Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9673767',\n",
       "   'xref_name': 'Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9673770',\n",
       "   'xref_name': 'Signaling by PDGFRA extracellular domain mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9703465',\n",
       "   'xref_name': 'Signaling by FLT3 fusion proteins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9703648',\n",
       "   'xref_name': 'Signaling by FLT3 ITD and TKD mutants.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P01112'},\n",
       "  {'component_synonym': 'HRAS', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL245': [{'xref_id': 'R-HSA-390648',\n",
       "   'xref_name': 'Muscarinic acetylcholine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-399997',\n",
       "   'xref_name': 'Acetylcholine regulates insulin secretion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P20309'},\n",
       "  {'component_synonym': 'CHRM3', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1987': [{'xref_id': 'R-HSA-391908',\n",
       "   'xref_name': 'Prostanoid ligand receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P43088'},\n",
       "  {'component_synonym': 'PTGFR', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2364702': [{'accession': 'E0VCW8'},\n",
       "  {'component_synonym': '8238086', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2095182': [{'xref_id': 'R-HSA-1445148',\n",
       "   'xref_name': 'Translocation of SLC2A4 (GLUT4) to the plasma membrane.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190840',\n",
       "   'xref_name': 'Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-190861',\n",
       "   'xref_name': 'Gap junction assembly.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2132295',\n",
       "   'xref_name': 'MHC class II antigen presentation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2467813',\n",
       "   'xref_name': 'Separation of Sister Chromatids.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2500257',\n",
       "   'xref_name': 'Resolution of Sister Chromatid Cohesion.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-2565942',\n",
       "   'xref_name': 'Regulation of PLK1 Activity at G2/M Transition.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-3371497',\n",
       "   'xref_name': 'HSP90 chaperone cycle for steroid hormone receptors (SHR).',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380259',\n",
       "   'xref_name': 'Loss of Nlp from mitotic centrosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380270',\n",
       "   'xref_name': 'Recruitment of mitotic centrosome proteins and complexes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380284',\n",
       "   'xref_name': 'Loss of proteins required for interphase microtubule organization from the centrosome.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-380320',\n",
       "   'xref_name': 'Recruitment of NuMA to mitotic centrosomes.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-389957',\n",
       "   'xref_name': 'Prefoldin mediated transfer of substrate to CCT/TriC.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-389960',\n",
       "   'xref_name': 'Formation of tubulin folding intermediates by CCT/TriC.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-389977',\n",
       "   'xref_name': 'Post-chaperonin tubulin folding pathway.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-437239',\n",
       "   'xref_name': 'Recycling pathway of L1.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5610787',\n",
       "   'xref_name': \"Hedgehog 'off' state.\",\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5617833',\n",
       "   'xref_name': 'Cilium Assembly.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5620912',\n",
       "   'xref_name': 'Anchoring of the basal body to the plasma membrane.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5620924',\n",
       "   'xref_name': 'Intraflagellar transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5626467',\n",
       "   'xref_name': 'RHO GTPases activate IQGAPs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-5663220',\n",
       "   'xref_name': 'RHO GTPases Activate Formins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6798695',\n",
       "   'xref_name': 'Neutrophil degranulation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6807878',\n",
       "   'xref_name': 'COPI-mediated anterograde transport.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811434',\n",
       "   'xref_name': 'COPI-dependent Golgi-to-ER retrograde traffic.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-6811436',\n",
       "   'xref_name': 'COPI-independent Golgi-to-ER retrograde traffic.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-68877',\n",
       "   'xref_name': 'Mitotic Prometaphase.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8852276',\n",
       "   'xref_name': 'The role of GTSE1 in G2/M progression after G2 checkpoint.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8854518',\n",
       "   'xref_name': 'AURKA Activation by TPX2.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-8955332',\n",
       "   'xref_name': 'Carboxyterminal post-translational modifications of tubulin.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9609690',\n",
       "   'xref_name': 'HCMV Early Events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9609736',\n",
       "   'xref_name': 'Assembly and cell surface presentation of NMDA receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9619483',\n",
       "   'xref_name': 'Activation of AMPK downstream of NMDARs.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9646399',\n",
       "   'xref_name': 'Aggrephagy.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9648025',\n",
       "   'xref_name': 'EML4 and NUDC in mitotic spindle formation.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-9668328',\n",
       "   'xref_name': 'Sealing of the nuclear envelope (NE) by ESCRT-III.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-983189',\n",
       "   'xref_name': 'Kinesins.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P68371'},\n",
       "  {'component_synonym': 'TUBB4B', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1780': [{'accession': 'P10613'},\n",
       "  {'component_synonym': 'ERG11', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL1952': [{'xref_id': 'R-HSA-499943',\n",
       "   'xref_name': 'Interconversion of nucleotide di- and triphosphates.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-69205',\n",
       "   'xref_name': 'G1/S-Specific Transcription.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P04818'},\n",
       "  {'component_synonym': 'TYMS', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL219': [{'xref_id': 'R-HSA-390651',\n",
       "   'xref_name': 'Dopamine receptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-418594',\n",
       "   'xref_name': 'G alpha (i) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P21917'},\n",
       "  {'component_synonym': 'DRD4', 'syn_type': 'GENE_SYMBOL'}],\n",
       " 'CHEMBL2331074': [{'xref_id': 'R-HSA-390696',\n",
       "   'xref_name': 'Adrenoceptors.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416476',\n",
       "   'xref_name': 'G alpha (q) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'xref_id': 'R-HSA-416482',\n",
       "   'xref_name': 'G alpha (12/13) signalling events.',\n",
       "   'xref_src_db': 'Reactome'},\n",
       "  {'accession': 'P35348'},\n",
       "  {'component_synonym': 'ADRA1A', 'syn_type': 'GENE_SYMBOL'}]}"
      ]
     },
     "execution_count": 59,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "chem2uni"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 53,
   "id": "2d04e21d",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "309"
      ]
     },
     "execution_count": 53,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "protList = Ret_uprotid(chem2uni)\n",
    "len(protList)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 54,
   "id": "131b541c",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
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      "https://www.uniprot.org/uniprot/P20292.txt\n",
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      "{'Gene': 'HTR2C'}\n",
      "https://www.uniprot.org/uniprot/Q9Y468.txt\n",
      "{'Gene': 'L3MBTL1'}\n",
      "https://www.uniprot.org/uniprot/Q99808.txt\n",
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      "{'Gene': 'BCHE'}\n",
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      "https://www.uniprot.org/uniprot/P20309.txt\n",
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      "https://www.uniprot.org/uniprot/Q02750.txt\n",
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      "{'Gene': 'NPSR1'}\n",
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      "https://www.uniprot.org/uniprot/P54132.txt\n",
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      "https://www.uniprot.org/uniprot/P25100.txt\n",
      "{'Gene': 'ADRA1D'}\n",
      "https://www.uniprot.org/uniprot/Q4U2R8.txt\n",
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      "{'Gene': 'HTR3A'}\n",
      "https://www.uniprot.org/uniprot/P46063.txt\n",
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      "{'Gene': 'PKM'}\n",
      "https://www.uniprot.org/uniprot/Q16539.txt\n",
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      "https://www.uniprot.org/uniprot/P30926.txt\n",
      "{'Gene': 'CHRNB4'}\n",
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      "{'Gene': 'NR3C1'}\n",
      "https://www.uniprot.org/uniprot/P22303.txt\n",
      "https://www.uniprot.org/uniprot/P68871.txt\n",
      "{'Gene': 'HBB'}\n",
      "https://www.uniprot.org/uniprot/O76074.txt\n",
      "https://www.uniprot.org/uniprot/P34903.txt\n",
      "{'Gene': 'GABRA3'}\n",
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      "{'Gene': 'HTR5A'}\n",
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      "{'Gene': 'ATP1A1'}\n",
      "https://www.uniprot.org/uniprot/Q13936.txt\n",
      "{'Gene': 'CACNA1C'}\n",
      "https://www.uniprot.org/uniprot/Q9Y5N1.txt\n",
      "{'Gene': 'HRH3'}\n",
      "https://www.uniprot.org/uniprot/O75496.txt\n",
      "{'Gene': 'GMNN'}\n",
      "https://www.uniprot.org/uniprot/O43570.txt\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "https://www.uniprot.org/uniprot/P09917.txt\n",
      "https://www.uniprot.org/uniprot/P25098.txt\n",
      "https://www.uniprot.org/uniprot/Q99720.txt\n",
      "{'Gene': 'SIGMAR1'}\n",
      "https://www.uniprot.org/uniprot/P35368.txt\n",
      "{'Gene': 'ADRA1B'}\n",
      "https://www.uniprot.org/uniprot/P50579.txt\n",
      "https://www.uniprot.org/uniprot/P50406.txt\n",
      "{'Gene': 'HTR6'}\n",
      "https://www.uniprot.org/uniprot/Q04828.txt\n",
      "{'Gene': 'AKR1C1'}\n",
      "https://www.uniprot.org/uniprot/B2RXH2.txt\n",
      "{'Gene': 'KDM4E'}\n",
      "https://www.uniprot.org/uniprot/Q00535.txt\n",
      "https://www.uniprot.org/uniprot/P08235.txt\n",
      "{'Gene': 'NR3C2'}\n",
      "https://www.uniprot.org/uniprot/Q14534.txt\n",
      "{'Gene': 'SQLE'}\n",
      "https://www.uniprot.org/uniprot/P08588.txt\n",
      "https://www.uniprot.org/uniprot/P02708.txt\n",
      "{'Gene': 'CHRNA1'}\n",
      "https://www.uniprot.org/uniprot/P37058.txt\n",
      "https://www.uniprot.org/uniprot/P17787.txt\n",
      "{'Gene': 'CHRNB2'}\n",
      "https://www.uniprot.org/uniprot/P15559.txt\n",
      "https://www.uniprot.org/uniprot/P01730.txt\n",
      "{'Gene': 'CD4'}\n",
      "https://www.uniprot.org/uniprot/Q01959.txt\n",
      "{'Gene': 'SLC6A3'}\n",
      "https://www.uniprot.org/uniprot/Q16637.txt\n",
      "{'Gene': 'SMN1'}\n",
      "https://www.uniprot.org/uniprot/P11229.txt\n",
      "{'Gene': 'CHRM1'}\n",
      "https://www.uniprot.org/uniprot/P05413.txt\n",
      "{'Gene': 'FABP3'}\n",
      "https://www.uniprot.org/uniprot/P48058.txt\n",
      "https://www.uniprot.org/uniprot/P42858.txt\n",
      "{'Gene': 'HTT'}\n",
      "https://www.uniprot.org/uniprot/P11802.txt\n",
      "{'Gene': 'CDK4'}\n",
      "https://www.uniprot.org/uniprot/P08172.txt\n",
      "{'Gene': 'CHRM2'}\n",
      "https://www.uniprot.org/uniprot/P00736.txt\n",
      "{'Gene': 'C1R'}\n",
      "https://www.uniprot.org/uniprot/Q99685.txt\n",
      "https://www.uniprot.org/uniprot/P19099.txt\n",
      "https://www.uniprot.org/uniprot/P04278.txt\n",
      "{'Gene': 'SHBG'}\n",
      "https://www.uniprot.org/uniprot/P05177.txt\n",
      "https://www.uniprot.org/uniprot/P00533.txt\n",
      "https://www.uniprot.org/uniprot/P05093.txt\n",
      "https://www.uniprot.org/uniprot/P07451.txt\n",
      "https://www.uniprot.org/uniprot/P62937.txt\n",
      "{'Gene': 'PPIA'}\n",
      "https://www.uniprot.org/uniprot/Q16478.txt\n",
      "{'Gene': 'GRIK5'}\n",
      "https://www.uniprot.org/uniprot/P34969.txt\n",
      "{'Gene': 'HTR7'}\n",
      "https://www.uniprot.org/uniprot/Q9UGC6.txt\n",
      "{'Gene': 'RGS17'}\n",
      "https://www.uniprot.org/uniprot/O15554.txt\n",
      "{'Gene': 'KCNN4'}\n",
      "https://www.uniprot.org/uniprot/P0DMS8.txt\n",
      "https://www.uniprot.org/uniprot/P28223.txt\n",
      "{'Gene': 'HTR2A'}\n",
      "https://www.uniprot.org/uniprot/Q9ULX7.txt\n",
      "{'Gene': 'CA14'}\n",
      "https://www.uniprot.org/uniprot/P55789.txt\n",
      "{'Gene': 'GFER'}\n",
      "https://www.uniprot.org/uniprot/P52895.txt\n",
      "{'Gene': 'AKR1C2'}\n",
      "https://www.uniprot.org/uniprot/Q07343.txt\n",
      "https://www.uniprot.org/uniprot/P56373.txt\n",
      "{'Gene': 'P2RX3'}\n",
      "https://www.uniprot.org/uniprot/P15090.txt\n",
      "{'Gene': 'FABP4'}\n",
      "https://www.uniprot.org/uniprot/P27815.txt\n",
      "{'Gene': 'PDE4A'}\n",
      "https://www.uniprot.org/uniprot/P23280.txt\n",
      "{'Gene': 'CA6'}\n",
      "https://www.uniprot.org/uniprot/P23526.txt\n",
      "{'Gene': 'AHCY'}\n",
      "https://www.uniprot.org/uniprot/P10635.txt\n",
      "https://www.uniprot.org/uniprot/P41146.txt\n",
      "{'Gene': 'OPRL1'}\n",
      "https://www.uniprot.org/uniprot/O75762.txt\n",
      "https://www.uniprot.org/uniprot/P10636.txt\n",
      "https://www.uniprot.org/uniprot/P35348.txt\n",
      "{'Gene': 'ADRA1A'}\n",
      "https://www.uniprot.org/uniprot/P10827.txt\n",
      "{'Gene': 'THRA'}\n",
      "https://www.uniprot.org/uniprot/P18825.txt\n",
      "{'Gene': 'ADRA2C'}\n",
      "https://www.uniprot.org/uniprot/Q05586.txt\n",
      "{'Gene': 'GRIN1'}\n",
      "https://www.uniprot.org/uniprot/P29371.txt\n",
      "{'Gene': 'TACR3'}\n",
      "https://www.uniprot.org/uniprot/Q96S37.txt\n",
      "{'Gene': 'SLC22A12'}\n",
      "https://www.uniprot.org/uniprot/O14976.txt\n",
      "{'Gene': 'GAK'}\n",
      "https://www.uniprot.org/uniprot/P14324.txt\n",
      "https://www.uniprot.org/uniprot/P08183.txt\n",
      "https://www.uniprot.org/uniprot/P20813.txt\n",
      "https://www.uniprot.org/uniprot/P40225.txt\n",
      "{'Gene': 'THPO'}\n",
      "https://www.uniprot.org/uniprot/P68400.txt\n",
      "{'Gene': 'CSNK2A1'}\n",
      "https://www.uniprot.org/uniprot/P33261.txt\n",
      "{'Gene': 'CYP2C19'}\n",
      "https://www.uniprot.org/uniprot/Q92769.txt\n",
      "https://www.uniprot.org/uniprot/Q04760.txt\n",
      "{'Gene': 'GLO1'}\n",
      "https://www.uniprot.org/uniprot/P35354.txt\n",
      "https://www.uniprot.org/uniprot/P27338.txt\n",
      "https://www.uniprot.org/uniprot/Q13956.txt\n",
      "{'Gene': 'PDE6H'}\n",
      "https://www.uniprot.org/uniprot/Q16853.txt\n",
      "{'Gene': 'AOC3'}\n",
      "https://www.uniprot.org/uniprot/Q08209.txt\n",
      "https://www.uniprot.org/uniprot/P12821.txt\n",
      "{'Gene': 'ACE'}\n",
      "https://www.uniprot.org/uniprot/Q9NUW8.txt\n",
      "{'Gene': 'TDP1'}\n",
      "https://www.uniprot.org/uniprot/P28482.txt\n",
      "https://www.uniprot.org/uniprot/Q96EB6.txt\n",
      "https://www.uniprot.org/uniprot/P21397.txt\n",
      "https://www.uniprot.org/uniprot/O15379.txt\n",
      "{'Gene': 'HDAC3'}\n",
      "https://www.uniprot.org/uniprot/P27815.txt\n",
      "{'Gene': 'PDE4A'}\n",
      "https://www.uniprot.org/uniprot/P11387.txt\n",
      "{'Gene': 'TOP1'}\n",
      "https://www.uniprot.org/uniprot/Q13255.txt\n",
      "{'Gene': 'GRM1'}\n",
      "https://www.uniprot.org/uniprot/P08588.txt\n",
      "https://www.uniprot.org/uniprot/Q99714.txt\n",
      "{'Gene': 'HSD17B10'}\n",
      "https://www.uniprot.org/uniprot/O43174.txt\n",
      "https://www.uniprot.org/uniprot/Q9BY41.txt\n",
      "https://www.uniprot.org/uniprot/Q15303.txt\n",
      "{'Gene': 'ERBB4'}\n",
      "https://www.uniprot.org/uniprot/P53779.txt\n",
      "{'Gene': 'MAPK10'}\n",
      "https://www.uniprot.org/uniprot/P27695.txt\n",
      "{'Gene': 'APEX1'}\n",
      "https://www.uniprot.org/uniprot/O43497.txt\n",
      "{'Gene': 'CACNA1G'}\n",
      "https://www.uniprot.org/uniprot/P03905.txt\n",
      "{'Gene': 'MT-ND4'}\n",
      "https://www.uniprot.org/uniprot/Q9P0X4.txt\n",
      "{'Gene': 'CACNA1I'}\n",
      "https://www.uniprot.org/uniprot/Q9UPY5.txt\n",
      "{'Gene': 'SLC7A11'}\n",
      "https://www.uniprot.org/uniprot/P30556.txt\n",
      "https://www.uniprot.org/uniprot/P07900.txt\n",
      "https://www.uniprot.org/uniprot/Q9H3N8.txt\n",
      "{'Gene': 'HRH4'}\n",
      "https://www.uniprot.org/uniprot/P41231.txt\n",
      "{'Gene': 'P2RY2'}\n",
      "https://www.uniprot.org/uniprot/P28845.txt\n",
      "https://www.uniprot.org/uniprot/P35462.txt\n",
      "https://www.uniprot.org/uniprot/P19793.txt\n",
      "{'Gene': 'RXRA'}\n",
      "https://www.uniprot.org/uniprot/P08173.txt\n",
      "{'Gene': 'CHRM4'}\n",
      "https://www.uniprot.org/uniprot/Q92731.txt\n",
      "{'Gene': 'ESR2'}\n",
      "https://www.uniprot.org/uniprot/P35367.txt\n",
      "{'Gene': 'HRH1'}\n",
      "https://www.uniprot.org/uniprot/P51575.txt\n",
      "{'Gene': 'P2RX1'}\n",
      "https://www.uniprot.org/uniprot/P45984.txt\n",
      "{'Gene': 'MAPK9'}\n",
      "https://www.uniprot.org/uniprot/Q03164.txt\n",
      "{'Gene': 'KMT2A'}\n",
      "https://www.uniprot.org/uniprot/P35968.txt\n",
      "https://www.uniprot.org/uniprot/P23975.txt\n",
      "{'Gene': 'SLC6A2'}\n",
      "https://www.uniprot.org/uniprot/Q13547.txt\n",
      "https://www.uniprot.org/uniprot/P10827.txt\n",
      "{'Gene': 'THRA'}\n",
      "https://www.uniprot.org/uniprot/P0AES6.txt\n",
      "https://www.uniprot.org/uniprot/P72355.txt\n",
      "https://www.uniprot.org/uniprot/Q14654.txt\n",
      "{'Gene': 'KCNJ11'}\n",
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      "{'Gene': 'SLC6A4'}\n",
      "https://www.uniprot.org/uniprot/Q96DB2.txt\n",
      "{'Gene': 'HDAC11'}\n",
      "https://www.uniprot.org/uniprot/P00748.txt\n",
      "{'Gene': 'F12'}\n",
      "https://www.uniprot.org/uniprot/P08684.txt\n",
      "https://www.uniprot.org/uniprot/Q8JXU8.txt\n",
      "https://www.uniprot.org/uniprot/Q969P6.txt\n",
      "{'Gene': 'TOP1MT'}\n",
      "https://www.uniprot.org/uniprot/P41595.txt\n",
      "{'Gene': 'HTR2B'}\n",
      "https://www.uniprot.org/uniprot/Q13621.txt\n",
      "{'Gene': 'SLC12A1'}\n",
      "https://www.uniprot.org/uniprot/P0AFI2.txt\n",
      "https://www.uniprot.org/uniprot/P35498.txt\n",
      "{'Gene': 'SCN1A'}\n",
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      "{'Gene': 'KCNJ11'}\n",
      "https://www.uniprot.org/uniprot/O76074.txt\n",
      "https://www.uniprot.org/uniprot/P21554.txt\n",
      "{'Gene': 'CNR1'}\n",
      "https://www.uniprot.org/uniprot/P24228.txt\n",
      "{'Gene': 'dacB'}\n",
      "https://www.uniprot.org/uniprot/P35354.txt\n",
      "https://www.uniprot.org/uniprot/Q93088.txt\n",
      "https://www.uniprot.org/uniprot/Q06203.txt\n",
      "{'Gene': 'PPAT'}\n",
      "https://www.uniprot.org/uniprot/P0A4L9.txt\n",
      "https://www.uniprot.org/uniprot/P11172.txt\n",
      "https://www.uniprot.org/uniprot/P07202.txt\n",
      "https://www.uniprot.org/uniprot/P06821.txt\n",
      "https://www.uniprot.org/uniprot/Q15842.txt\n",
      "{'Gene': 'KCNJ8'}\n",
      "https://www.uniprot.org/uniprot/P0AC13.txt\n",
      "{'Gene': 'folP'}\n",
      "https://www.uniprot.org/uniprot/A2PZ98.txt\n",
      "https://www.uniprot.org/uniprot/P51787.txt\n",
      "https://www.uniprot.org/uniprot/Q72874.txt\n",
      "https://www.uniprot.org/uniprot/P55017.txt\n",
      "{'Gene': 'SLC12A3'}\n",
      "https://www.uniprot.org/uniprot/Q9BQB6.txt\n",
      "{'Gene': 'VKORC1'}\n",
      "https://www.uniprot.org/uniprot/Q72547.txt\n",
      "https://www.uniprot.org/uniprot/P20839.txt\n",
      "https://www.uniprot.org/uniprot/P02708.txt\n",
      "{'Gene': 'CHRNA1'}\n",
      "https://www.uniprot.org/uniprot/Q12879.txt\n",
      "{'Gene': 'GRIN2A'}\n",
      "https://www.uniprot.org/uniprot/P0A7V0.txt\n",
      "{'Gene': 'rpsB'}\n",
      "https://www.uniprot.org/uniprot/P14416.txt\n",
      "{'Gene': 'DRD2'}\n",
      "https://www.uniprot.org/uniprot/P0AEK4.txt\n",
      "{'Gene': 'fabI'}\n",
      "https://www.uniprot.org/uniprot/P30542.txt\n",
      "{'Gene': 'ADORA1'}\n",
      "https://www.uniprot.org/uniprot/P09884.txt\n",
      "{'Gene': 'POLA1'}\n",
      "https://www.uniprot.org/uniprot/P72525.txt\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "https://www.uniprot.org/uniprot/P05230.txt\n",
      "{'Gene': 'FGF1'}\n",
      "https://www.uniprot.org/uniprot/P01112.txt\n",
      "{'Gene': 'HRAS'}\n",
      "https://www.uniprot.org/uniprot/P20309.txt\n",
      "{'Gene': 'CHRM3'}\n",
      "https://www.uniprot.org/uniprot/P43088.txt\n",
      "{'Gene': 'PTGFR'}\n",
      "https://www.uniprot.org/uniprot/E0VCW8.txt\n",
      "https://www.uniprot.org/uniprot/P68371.txt\n",
      "{'Gene': 'TUBB4B'}\n",
      "https://www.uniprot.org/uniprot/P10613.txt\n",
      "https://www.uniprot.org/uniprot/P04818.txt\n",
      "https://www.uniprot.org/uniprot/P21917.txt\n",
      "{'Gene': 'DRD4'}\n",
      "https://www.uniprot.org/uniprot/P35348.txt\n",
      "{'Gene': 'ADRA1A'}\n"
     ]
    }
   ],
   "source": [
    "protList_ext = ExtractFromUniProt(protList)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 55,
   "id": "cde94c89",
   "metadata": {},
   "outputs": [],
   "source": [
    "# filename = 'data/normalized_data/allprot_fromchembl'\n",
    "# outfile = open(filename,'wb')\n",
    "# pickle.dump(protList_ext,outfile)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 57,
   "id": "6a6f2a6f",
   "metadata": {},
   "outputs": [],
   "source": [
    "infile = open('data/normalized_data/allprot_fromchembl','rb')\n",
    "allprot = pickle.load(infile)\n",
    "infile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 76,
   "id": "8275de1f",
   "metadata": {},
   "outputs": [],
   "source": [
    "#mpox_graph = pybel.BELGraph(name='Monkeypox Graph')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 115,
   "id": "95598efb",
   "metadata": {},
   "outputs": [],
   "source": [
    "mpox_graph = uniprot_rel(allprot,'HGNC',mpox_graph)\n",
    "pchem_act_new= chembl2gene2path(chem2uni,chem2act)\n",
    "pchem_mech_new = chembl2gene2path(chem2uni,chem2mech)\n",
    "mpox_graph = chem2act_rel_2(pchem_act_new,'HGNC',mpox_graph)\n",
    "mpox_graph = chem2moa_rel_2(pchem_mech_new,'HGNC',mpox_graph)\n",
    "mpox_graph = chem2dis_rel(chem2dis,mpox_graph)\n",
    "mpox_graph = chem2gene2path_rel(chem2uni,'HGNC',mpox_graph)\n",
    "#to_jupyter(mpox_graph)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "347a0872",
   "metadata": {},
   "outputs": [],
   "source": [
    "chem2uni['CHEMBL2094125'][2]['component_synonym']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 82,
   "id": "df267060",
   "metadata": {},
   "outputs": [],
   "source": [
    "# filename = 'data/normalized_data/monkeypox_pickle_final_25thJuly'\n",
    "# outfile = open(filename,'wb')\n",
    "# pickle.dump(mpox_graph,outfile)\n",
    "# outfile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 74,
   "id": "ebf58a54",
   "metadata": {},
   "outputs": [],
   "source": [
    "infile = open('data/normalized_data/monkeypox_pickle_final_25thJuly','rb')\n",
    "mpox_graph = pickle.load(infile)\n",
    "infile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 116,
   "id": "d8d8479d",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "            <h2>Metadata</h2>\n",
       "            <table>\n",
       "<tbody>\n",
       "<tr><td>Name   </td><td>Monkeypox Graph</td></tr>\n",
       "<tr><td>Version</td><td>               </td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Statistics</h2>\n",
       "            <table>\n",
       "<tbody>\n",
       "<tr><td>Nodes          </td><td style=\"text-align: right;\"> 4916       </td></tr>\n",
       "<tr><td>Namespaces     </td><td style=\"text-align: right;\">    9       </td></tr>\n",
       "<tr><td>Edges          </td><td style=\"text-align: right;\">20962       </td></tr>\n",
       "<tr><td>Annotations    </td><td style=\"text-align: right;\">    0       </td></tr>\n",
       "<tr><td>Citations      </td><td style=\"text-align: right;\">    2       </td></tr>\n",
       "<tr><td>Authors        </td><td style=\"text-align: right;\">    0       </td></tr>\n",
       "<tr><td>Components     </td><td style=\"text-align: right;\">    3       </td></tr>\n",
       "<tr><td>Warnings       </td><td style=\"text-align: right;\">    0       </td></tr>\n",
       "<tr><td>Network Density</td><td style=\"text-align: right;\">    0.000868</td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Nodes</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Type             </th><th style=\"text-align: right;\">  Count</th><th>Example                                               </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>BiologicalProcess</td><td style=\"text-align: right;\">   2195</td><td>bp(GOBP:&quot;regulation of cell population proliferation&quot;)</td></tr>\n",
       "<tr><td>Abundance        </td><td style=\"text-align: right;\">   1427</td><td>a(ChEMBLAssay:CHEMBL655882)                           </td></tr>\n",
       "<tr><td>Pathology        </td><td style=\"text-align: right;\">    907</td><td>path(Disease:&quot;Guillain-Barre Syndrome&quot;)               </td></tr>\n",
       "<tr><td>Protein          </td><td style=\"text-align: right;\">    387</td><td>p(HGNC:CHEMBL614184)                                  </td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Namespaces</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Prefix     </th><th>Name                            </th><th style=\"text-align: right;\">  Count</th><th>Example                                                             </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>Disease    </td><td>                                </td><td style=\"text-align: right;\">    907</td><td>path(Disease:&quot;Amyotrophic Lateral Sclerosis&quot;)                       </td></tr>\n",
       "<tr><td>ChEMBLAssay</td><td>                                </td><td style=\"text-align: right;\">    862</td><td>a(ChEMBLAssay:CHEMBL821993)                                         </td></tr>\n",
       "<tr><td>GOBP       </td><td>Gene Ontology                   </td><td style=\"text-align: right;\">    774</td><td>bp(GOBP:&quot;negative regulation of transcription by RNA polymerase II&quot;)</td></tr>\n",
       "<tr><td>Reactome   </td><td>Reactome                        </td><td style=\"text-align: right;\">    751</td><td>bp(Reactome:&quot;Interleukin-1 processing.&quot;)                            </td></tr>\n",
       "<tr><td>ChEMBL     </td><td>ChEMBL                          </td><td style=\"text-align: right;\">    565</td><td>a(ChEMBL:CHEMBL24640)                                               </td></tr>\n",
       "<tr><td>GOMF       </td><td>Gene Ontology                   </td><td style=\"text-align: right;\">    537</td><td>bp(GOMF:&quot;structural constituent of cytoskeleton&quot;)                   </td></tr>\n",
       "<tr><td>HGNC       </td><td>HUGO Gene Nomenclature Committee</td><td style=\"text-align: right;\">    377</td><td>p(HGNC:CHRM2)                                                       </td></tr>\n",
       "<tr><td>MOA        </td><td>                                </td><td style=\"text-align: right;\">    133</td><td>bp(MOA:&quot;Tubulin inhibitor&quot;)                                         </td></tr>\n",
       "<tr><td>MPXV       </td><td>                                </td><td style=\"text-align: right;\">     10</td><td>p(MPXV:Q8V4T3)                                                      </td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Edges</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Edge Type                              </th><th style=\"text-align: right;\">  Count</th><th>Example                                                                             </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>Protein association BiologicalProcess  </td><td style=\"text-align: right;\">   4054</td><td>p(HGNC:TPO) association bp(GOMF:&quot;calcium ion binding&quot;)                              </td></tr>\n",
       "<tr><td>Pathology association Abundance        </td><td style=\"text-align: right;\">   3401</td><td>path(Disease:&quot;Lung Diseases&quot;) association a(ChEMBL:CHEMBL269732)                    </td></tr>\n",
       "<tr><td>Protein association Abundance          </td><td style=\"text-align: right;\">   1090</td><td>p(HGNC:RAB9A) association a(ChEMBLAssay:CHEMBL1613838)                              </td></tr>\n",
       "<tr><td>BiologicalProcess association Abundance</td><td style=\"text-align: right;\">    246</td><td>bp(MOA:&quot;Alpha-1d adrenergic receptor antagonist&quot;) association a(ChEMBL:CHEMBL142635)</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/plain": [
       "<pybel.struct.graph.SummarizeDispatch at 0x198025c16f0>"
      ]
     },
     "execution_count": 116,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mpox_graph.summarize"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 85,
   "id": "77a6c09c",
   "metadata": {},
   "outputs": [],
   "source": [
    "chembl_id = []\n",
    "for node in mpox_graph.nodes():\n",
    "    if isinstance(node,pybel.dsl.Abundance):\n",
    "        if node.namespace == 'ChEMBL':\n",
    "            chembl_id.append(node.name)\n",
    "            \n",
    "    "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 86,
   "id": "c95e946c",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "565"
      ]
     },
     "execution_count": 86,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(chembl_id)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 117,
   "id": "1fff6fe5",
   "metadata": {},
   "outputs": [],
   "source": [
    "def chembl2rxn_rel(itmpGraph):\n",
    "    \n",
    "    infile = open('data/normalized_data/drugReactions.pkl','rb')\n",
    "    rxn_df = pickle.load(infile)\n",
    "    infile.close()\n",
    "    \n",
    "    chembl_id = []\n",
    "    for node in itmpGraph.nodes():\n",
    "        if isinstance(node,pybel.dsl.Abundance):\n",
    "            if node.namespace == 'ChEMBL':\n",
    "                chembl_id.append(node.name)\n",
    "            \n",
    "    chembl_id_rxn = rxn_df[rxn_df['chembl_id'].isin(chembl_id)]\n",
    "    chembl_id_rxn = chembl_id_rxn.reset_index(drop=True)\n",
    "    for i in range(len(chembl_id_rxn)):\n",
    "        itmpGraph.add_association(Abundance(namespace='ChEMBL',name = chembl_id_rxn['chembl_id'][i]),\n",
    "                                  Pathology(namespace='SideEffect',name = chembl_id_rxn['event'][i]),\n",
    "                                  citation = \"OpenTargets Platform\",evidence = 'DrugReactions')\n",
    "        \n",
    "    return(itmpGraph)\n",
    "                                                                                            \n",
    "    "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 118,
   "id": "9d071c3c",
   "metadata": {},
   "outputs": [],
   "source": [
    "mpox_graph = chembl2rxn_rel(mpox_graph)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 119,
   "id": "13e75ada",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "            <h2>Metadata</h2>\n",
       "            <table>\n",
       "<tbody>\n",
       "<tr><td>Name   </td><td>Monkeypox Graph</td></tr>\n",
       "<tr><td>Version</td><td>               </td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Statistics</h2>\n",
       "            <table>\n",
       "<tbody>\n",
       "<tr><td>Nodes          </td><td style=\"text-align: right;\"> 8235       </td></tr>\n",
       "<tr><td>Namespaces     </td><td style=\"text-align: right;\">   10       </td></tr>\n",
       "<tr><td>Edges          </td><td style=\"text-align: right;\">40422       </td></tr>\n",
       "<tr><td>Annotations    </td><td style=\"text-align: right;\">    0       </td></tr>\n",
       "<tr><td>Citations      </td><td style=\"text-align: right;\">    3       </td></tr>\n",
       "<tr><td>Authors        </td><td style=\"text-align: right;\">    0       </td></tr>\n",
       "<tr><td>Components     </td><td style=\"text-align: right;\">    3       </td></tr>\n",
       "<tr><td>Warnings       </td><td style=\"text-align: right;\">    0       </td></tr>\n",
       "<tr><td>Network Density</td><td style=\"text-align: right;\">    0.000596</td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Nodes</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Type             </th><th style=\"text-align: right;\">  Count</th><th>Example                                     </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>Pathology        </td><td style=\"text-align: right;\">   4226</td><td>path(SideEffect:&quot;anal atresia&quot;)             </td></tr>\n",
       "<tr><td>BiologicalProcess</td><td style=\"text-align: right;\">   2195</td><td>bp(GOMF:&quot;lysine-acetylated histone binding&quot;)</td></tr>\n",
       "<tr><td>Abundance        </td><td style=\"text-align: right;\">   1427</td><td>a(ChEMBLAssay:CHEMBL1060408)                </td></tr>\n",
       "<tr><td>Protein          </td><td style=\"text-align: right;\">    387</td><td>p(HGNC:PDE4B)                               </td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Namespaces</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Prefix     </th><th>Name                            </th><th style=\"text-align: right;\">  Count</th><th>Example                                                   </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>SideEffect </td><td>                                </td><td style=\"text-align: right;\">   3319</td><td>path(SideEffect:&quot;antidiuretic hormone abnormality&quot;)       </td></tr>\n",
       "<tr><td>Disease    </td><td>                                </td><td style=\"text-align: right;\">    907</td><td>path(Disease:&quot;Lymphoma, Follicular&quot;)                      </td></tr>\n",
       "<tr><td>ChEMBLAssay</td><td>                                </td><td style=\"text-align: right;\">    862</td><td>a(ChEMBLAssay:CHEMBL648617)                               </td></tr>\n",
       "<tr><td>GOBP       </td><td>Gene Ontology                   </td><td style=\"text-align: right;\">    774</td><td>bp(GOBP:&quot;apoptotic cell clearance&quot;)                       </td></tr>\n",
       "<tr><td>Reactome   </td><td>Reactome                        </td><td style=\"text-align: right;\">    751</td><td>bp(Reactome:&quot;Dopamine clearance from the synaptic cleft.&quot;)</td></tr>\n",
       "<tr><td>ChEMBL     </td><td>ChEMBL                          </td><td style=\"text-align: right;\">    565</td><td>a(ChEMBL:CHEMBL822)                                       </td></tr>\n",
       "<tr><td>GOMF       </td><td>Gene Ontology                   </td><td style=\"text-align: right;\">    537</td><td>bp(GOMF:&quot;3&#x27;-tyrosyl-DNA phosphodiesterase activity&quot;)      </td></tr>\n",
       "<tr><td>HGNC       </td><td>HUGO Gene Nomenclature Committee</td><td style=\"text-align: right;\">    377</td><td>p(HGNC:CHEMBL614245)                                      </td></tr>\n",
       "<tr><td>MOA        </td><td>                                </td><td style=\"text-align: right;\">    133</td><td>bp(MOA:&quot;Glucocorticoid receptor agonist&quot;)                 </td></tr>\n",
       "<tr><td>MPXV       </td><td>                                </td><td style=\"text-align: right;\">     10</td><td>p(MPXV:p28)                                               </td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "            <h2>Edges</h2>\n",
       "            <table>\n",
       "<thead>\n",
       "<tr><th>Edge Type                              </th><th style=\"text-align: right;\">  Count</th><th>Example                                                                                         </th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "<tr><td>Pathology association Abundance        </td><td style=\"text-align: right;\">  13131</td><td>path(Disease:&quot;Kidney Diseases&quot;) association a(ChEMBL:CHEMBL163)                                 </td></tr>\n",
       "<tr><td>Protein association BiologicalProcess  </td><td style=\"text-align: right;\">   4054</td><td>p(HGNC:CYP26A1) association bp(GOBP:&quot;retinoic acid catabolic process&quot;)                          </td></tr>\n",
       "<tr><td>Protein association Abundance          </td><td style=\"text-align: right;\">   1090</td><td>p(HGNC:KDR) association a(ChEMBLAssay:CHEMBL676766)                                             </td></tr>\n",
       "<tr><td>BiologicalProcess association Abundance</td><td style=\"text-align: right;\">    246</td><td>bp(MOA:&quot;Human immunodeficiency virus type 1 protease inhibitor&quot;) association a(ChEMBL:CHEMBL116)</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/plain": [
       "<pybel.struct.graph.SummarizeDispatch at 0x198025c16f0>"
      ]
     },
     "execution_count": 119,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mpox_graph.summarize"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 121,
   "id": "c21e3929",
   "metadata": {},
   "outputs": [],
   "source": [
    "filename = 'data/normalized_data/monkeypox_pickle_final_25thJuly.pkl'\n",
    "outfile = open(filename,'wb')\n",
    "pickle.dump(mpox_graph,outfile)\n",
    "outfile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "id": "c8f98ab8",
   "metadata": {},
   "outputs": [],
   "source": [
    "infile = open('data/normalized_data/monkeypox_pickle_final_25thJuly.pkl','rb')\n",
    "mpox_graph = pickle.load(infile)\n",
    "infile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 92,
   "id": "3a31fb54",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Type (4)             Count  Example\n",
      "-----------------  -------  ------------------------------------------------\n",
      "Pathology             4226  path(SideEffect:\"endometrial cancer\")\n",
      "BiologicalProcess     2195  bp(GOBP:\"cellular response to glucose stimulus\")\n",
      "Abundance             1427  a(ChEMBL:CHEMBL1514715)\n",
      "Protein                387  p(HGNC:BLM)\n"
     ]
    }
   ],
   "source": [
    "test = mpox_graph.summarize.nodes()\n",
    "test"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "607283c6",
   "metadata": {},
   "outputs": [],
   "source": [
    "mpox_graph"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "id": "c6fb5a8f",
   "metadata": {},
   "outputs": [],
   "source": [
    "infile = open('data/normalized_data/targets.pkl','rb')\n",
    "targetability = pickle.load(infile)\n",
    "infile.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "id": "2ef1846a",
   "metadata": {},
   "outputs": [],
   "source": [
    "protein = []\n",
    "for node in mpox_graph.nodes():\n",
    "    if isinstance(node,pybel.dsl.Protein):\n",
    "        if node.namespace == 'HGNC':\n",
    "            protein.append(node.name)\n",
    "            \n",
    "            "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "id": "95116643",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "377"
      ]
     },
     "execution_count": 7,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(protein)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "id": "f9c0a7ef",
   "metadata": {},
   "outputs": [],
   "source": [
    "targetability = targetability[targetability['approvedSymbol'].isin(protein)]\n",
    "targetability = targetability.reset_index(drop=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "id": "a0bdc62d",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>id</th>\n",
       "      <th>approvedSymbol</th>\n",
       "      <th>biotype</th>\n",
       "      <th>transcriptIds</th>\n",
       "      <th>genomicLocation</th>\n",
       "      <th>alternativeGenes</th>\n",
       "      <th>approvedName</th>\n",
       "      <th>go</th>\n",
       "      <th>hallmarks</th>\n",
       "      <th>synonyms</th>\n",
       "      <th>...</th>\n",
       "      <th>obsoleteNames</th>\n",
       "      <th>constraint</th>\n",
       "      <th>tep</th>\n",
       "      <th>proteinIds</th>\n",
       "      <th>dbXrefs</th>\n",
       "      <th>chemicalProbes</th>\n",
       "      <th>homologues</th>\n",
       "      <th>tractability</th>\n",
       "      <th>safetyLiabilities</th>\n",
       "      <th>pathways</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>ENSG00000115705</td>\n",
       "      <td>TPO</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000650224, ENST00000382269, ENST0000032...</td>\n",
       "      <td>{'chromosome': '2', 'start': 1374066, 'end': 1...</td>\n",
       "      <td>None</td>\n",
       "      <td>thyroid peroxidase</td>\n",
       "      <td>[{'id': 'GO:0098869', 'source': 'GO_REF:000010...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': 'Thyroid peroxidase', 'source': 'un...</td>\n",
       "      <td>...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': -0.8653900...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P07202', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '12015', 'source': 'HGNC'}, {'id': 'CH...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'speciesId': '9598', 'speciesName': 'Chimpan...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-209968', 'pathway': 'Thy...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>ENSG00000080824</td>\n",
       "      <td>HSP90AA1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000216281, ENST00000557089, ENST0000056...</td>\n",
       "      <td>{'chromosome': '14', 'start': 102080742, 'end'...</td>\n",
       "      <td>None</td>\n",
       "      <td>heat shock protein 90 alpha family class A mem...</td>\n",
       "      <td>[{'id': 'GO:0005829', 'source': 'Reactome:R-HS...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': 'Heat shock protein HSP 90-alpha', ...</td>\n",
       "      <td>...</td>\n",
       "      <td>[{'label': 'heat shock 90kD protein 1, alpha',...</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': -8.6224002...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P07900', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '5253', 'source': 'HGNC'}, {'id': '1BY...</td>\n",
       "      <td>[{'control': None, 'drugId': 'CHEMBL467399', '...</td>\n",
       "      <td>[{'speciesId': '9606', 'speciesName': 'Human',...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-9009391', 'pathway': 'Ex...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ENSG00000158748</td>\n",
       "      <td>HTR6</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000289753]</td>\n",
       "      <td>{'chromosome': '1', 'start': 19664875, 'end': ...</td>\n",
       "      <td>None</td>\n",
       "      <td>5-hydroxytryptamine receptor 6</td>\n",
       "      <td>[{'id': 'GO:0030425', 'source': 'PMID:21873635...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': '5-hydroxytryptamine receptor 6', '...</td>\n",
       "      <td>...</td>\n",
       "      <td>[{'label': '5-hydroxytryptamine (serotonin) re...</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': -0.9145399...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P50406', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '5301', 'source': 'HGNC'}, {'id': 'CHE...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'speciesId': '9606', 'speciesName': 'Human',...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>[{'event': 'receptor binding', 'eventId': None...</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-418555', 'pathway': 'G a...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ENSG00000123595</td>\n",
       "      <td>RAB9A</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000464506, ENST00000618931, ENST0000024...</td>\n",
       "      <td>{'chromosome': 'X', 'start': 13689128, 'end': ...</td>\n",
       "      <td>None</td>\n",
       "      <td>RAB9A, member RAS oncogene family</td>\n",
       "      <td>[{'id': 'GO:0042470', 'source': 'GO_REF:000002...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': 'Ras-related protein Rab-9A', 'sour...</td>\n",
       "      <td>...</td>\n",
       "      <td>[{'label': 'RAB9, member RAS oncogene family',...</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': 0.95749002...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P51151', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '9792', 'source': 'HGNC'}, {'id': '1WM...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'speciesId': '9606', 'speciesName': 'Human',...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-8873719', 'pathway': 'RA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ENSG00000170425</td>\n",
       "      <td>ADORA2B</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000304222, ENST00000582124]</td>\n",
       "      <td>{'chromosome': '17', 'start': 15945130, 'end':...</td>\n",
       "      <td>None</td>\n",
       "      <td>adenosine A2b receptor</td>\n",
       "      <td>[{'id': 'GO:0005886', 'source': 'Reactome:R-HS...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': 'Adenosine receptor A2b', 'source':...</td>\n",
       "      <td>...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': 0.42638000...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P29275', 'source': 'uniprot_swissprot'}]</td>\n",
       "      <td>[{'id': '264', 'source': 'HGNC'}, {'id': 'CHEM...</td>\n",
       "      <td>[{'control': None, 'drugId': None, 'id': 'MRS1...</td>\n",
       "      <td>[{'speciesId': '9606', 'speciesName': 'Human',...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>[{'event': 'increased/decreased inflammation',...</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-417973', 'pathway': 'Ade...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>275</th>\n",
       "      <td>ENSG00000244731</td>\n",
       "      <td>C4A</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000460060, ENST00000470365, ENST0000046...</td>\n",
       "      <td>{'chromosome': '6', 'start': 31982057, 'end': ...</td>\n",
       "      <td>[ENSG00000227746, ENSG00000206340]</td>\n",
       "      <td>complement C4A (Rodgers blood group)</td>\n",
       "      <td>[{'id': 'GO:0005886', 'source': 'Reactome:R-HS...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': 'Complement C4-A', 'source': 'unipr...</td>\n",
       "      <td>...</td>\n",
       "      <td>[{'label': 'complement component 4A', 'source'...</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': 1.40649998...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P0C0L4', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '1323', 'source': 'HGNC'}, {'id': '1HZ...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'speciesId': '9598', 'speciesName': 'Chimpan...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-977606', 'pathway': 'Reg...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>276</th>\n",
       "      <td>ENSG00000175591</td>\n",
       "      <td>P2RY2</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000393597, ENST00000393596, ENST0000031...</td>\n",
       "      <td>{'chromosome': '11', 'start': 73218281, 'end':...</td>\n",
       "      <td>None</td>\n",
       "      <td>purinergic receptor P2Y2</td>\n",
       "      <td>[{'id': 'GO:0007186', 'source': 'PMID:21873635...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': 'P2Y purinoceptor 2', 'source': 'un...</td>\n",
       "      <td>...</td>\n",
       "      <td>[{'label': 'purinergic receptor P2Y, G-protein...</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': 0.44786998...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P41231', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '8541', 'source': 'HGNC'}, {'id': 'CHE...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'speciesId': '9606', 'speciesName': 'Human',...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-417957', 'pathway': 'P2Y...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>277</th>\n",
       "      <td>ENSG00000133895</td>\n",
       "      <td>MEN1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000312049, ENST00000672079, ENST0000067...</td>\n",
       "      <td>{'chromosome': '11', 'start': 64803510, 'end':...</td>\n",
       "      <td>None</td>\n",
       "      <td>menin 1</td>\n",
       "      <td>[{'id': 'GO:0032925', 'source': 'GO_REF:000010...</td>\n",
       "      <td>{'attributes': [{'pmid': 25822367, 'descriptio...</td>\n",
       "      <td>[{'label': 'Menin', 'source': 'uniprot'}, {'la...</td>\n",
       "      <td>...</td>\n",
       "      <td>[{'label': 'multiple endocrine neoplasia I', '...</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': 0.75444000...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'O00255', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '7010', 'source': 'HGNC'}, {'id': '3U8...</td>\n",
       "      <td>[{'control': None, 'drugId': None, 'id': 'MI-2...</td>\n",
       "      <td>[{'speciesId': '9598', 'speciesName': 'Chimpan...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-5626467', 'pathway': 'RH...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>278</th>\n",
       "      <td>ENSG00000178035</td>\n",
       "      <td>IMPDH2</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000496837, ENST00000677168, ENST0000067...</td>\n",
       "      <td>{'chromosome': '3', 'start': 49024325, 'end': ...</td>\n",
       "      <td>None</td>\n",
       "      <td>inosine monophosphate dehydrogenase 2</td>\n",
       "      <td>[{'id': 'GO:0097294', 'source': 'GO_REF:000010...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': 'Inosine-5'-monophosphate dehydroge...</td>\n",
       "      <td>...</td>\n",
       "      <td>[{'label': 'IMP (inosine 5'-monophosphate) deh...</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': -0.9308099...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P12268', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '6053', 'source': 'HGNC'}, {'id': '1B3...</td>\n",
       "      <td>[{'control': None, 'drugId': None, 'id': 'BMS ...</td>\n",
       "      <td>[{'speciesId': '9606', 'speciesName': 'Human',...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-6798695', 'pathway': 'Ne...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>279</th>\n",
       "      <td>ENSG00000196262</td>\n",
       "      <td>PPIA</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>[ENST00000678805, ENST00000678165, ENST0000067...</td>\n",
       "      <td>{'chromosome': '7', 'start': 44796680, 'end': ...</td>\n",
       "      <td>None</td>\n",
       "      <td>peptidylprolyl isomerase A</td>\n",
       "      <td>[{'id': 'GO:0005829', 'source': 'Reactome:R-HS...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'label': 'Peptidyl-prolyl cis-trans isomeras...</td>\n",
       "      <td>...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'constraintType': 'syn', 'score': -0.0022607...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'id': 'P62937', 'source': 'uniprot_swissprot...</td>\n",
       "      <td>[{'id': '9253', 'source': 'HGNC'}, {'id': '1AK...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'speciesId': '9606', 'speciesName': 'Human',...</td>\n",
       "      <td>[{'modality': 'SM', 'id': 'Approved Drug', 'va...</td>\n",
       "      <td>None</td>\n",
       "      <td>[{'pathwayId': 'R-HSA-114608', 'pathway': 'Pla...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>280 rows × 26 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                  id approvedSymbol         biotype  \\\n",
       "0    ENSG00000115705            TPO  protein_coding   \n",
       "1    ENSG00000080824       HSP90AA1  protein_coding   \n",
       "2    ENSG00000158748           HTR6  protein_coding   \n",
       "3    ENSG00000123595          RAB9A  protein_coding   \n",
       "4    ENSG00000170425        ADORA2B  protein_coding   \n",
       "..               ...            ...             ...   \n",
       "275  ENSG00000244731            C4A  protein_coding   \n",
       "276  ENSG00000175591          P2RY2  protein_coding   \n",
       "277  ENSG00000133895           MEN1  protein_coding   \n",
       "278  ENSG00000178035         IMPDH2  protein_coding   \n",
       "279  ENSG00000196262           PPIA  protein_coding   \n",
       "\n",
       "                                         transcriptIds  \\\n",
       "0    [ENST00000650224, ENST00000382269, ENST0000032...   \n",
       "1    [ENST00000216281, ENST00000557089, ENST0000056...   \n",
       "2                                    [ENST00000289753]   \n",
       "3    [ENST00000464506, ENST00000618931, ENST0000024...   \n",
       "4                   [ENST00000304222, ENST00000582124]   \n",
       "..                                                 ...   \n",
       "275  [ENST00000460060, ENST00000470365, ENST0000046...   \n",
       "276  [ENST00000393597, ENST00000393596, ENST0000031...   \n",
       "277  [ENST00000312049, ENST00000672079, ENST0000067...   \n",
       "278  [ENST00000496837, ENST00000677168, ENST0000067...   \n",
       "279  [ENST00000678805, ENST00000678165, ENST0000067...   \n",
       "\n",
       "                                       genomicLocation  \\\n",
       "0    {'chromosome': '2', 'start': 1374066, 'end': 1...   \n",
       "1    {'chromosome': '14', 'start': 102080742, 'end'...   \n",
       "2    {'chromosome': '1', 'start': 19664875, 'end': ...   \n",
       "3    {'chromosome': 'X', 'start': 13689128, 'end': ...   \n",
       "4    {'chromosome': '17', 'start': 15945130, 'end':...   \n",
       "..                                                 ...   \n",
       "275  {'chromosome': '6', 'start': 31982057, 'end': ...   \n",
       "276  {'chromosome': '11', 'start': 73218281, 'end':...   \n",
       "277  {'chromosome': '11', 'start': 64803510, 'end':...   \n",
       "278  {'chromosome': '3', 'start': 49024325, 'end': ...   \n",
       "279  {'chromosome': '7', 'start': 44796680, 'end': ...   \n",
       "\n",
       "                       alternativeGenes  \\\n",
       "0                                  None   \n",
       "1                                  None   \n",
       "2                                  None   \n",
       "3                                  None   \n",
       "4                                  None   \n",
       "..                                  ...   \n",
       "275  [ENSG00000227746, ENSG00000206340]   \n",
       "276                                None   \n",
       "277                                None   \n",
       "278                                None   \n",
       "279                                None   \n",
       "\n",
       "                                          approvedName  \\\n",
       "0                                   thyroid peroxidase   \n",
       "1    heat shock protein 90 alpha family class A mem...   \n",
       "2                       5-hydroxytryptamine receptor 6   \n",
       "3                    RAB9A, member RAS oncogene family   \n",
       "4                               adenosine A2b receptor   \n",
       "..                                                 ...   \n",
       "275               complement C4A (Rodgers blood group)   \n",
       "276                           purinergic receptor P2Y2   \n",
       "277                                            menin 1   \n",
       "278              inosine monophosphate dehydrogenase 2   \n",
       "279                         peptidylprolyl isomerase A   \n",
       "\n",
       "                                                    go  \\\n",
       "0    [{'id': 'GO:0098869', 'source': 'GO_REF:000010...   \n",
       "1    [{'id': 'GO:0005829', 'source': 'Reactome:R-HS...   \n",
       "2    [{'id': 'GO:0030425', 'source': 'PMID:21873635...   \n",
       "3    [{'id': 'GO:0042470', 'source': 'GO_REF:000002...   \n",
       "4    [{'id': 'GO:0005886', 'source': 'Reactome:R-HS...   \n",
       "..                                                 ...   \n",
       "275  [{'id': 'GO:0005886', 'source': 'Reactome:R-HS...   \n",
       "276  [{'id': 'GO:0007186', 'source': 'PMID:21873635...   \n",
       "277  [{'id': 'GO:0032925', 'source': 'GO_REF:000010...   \n",
       "278  [{'id': 'GO:0097294', 'source': 'GO_REF:000010...   \n",
       "279  [{'id': 'GO:0005829', 'source': 'Reactome:R-HS...   \n",
       "\n",
       "                                             hallmarks  \\\n",
       "0                                                 None   \n",
       "1                                                 None   \n",
       "2                                                 None   \n",
       "3                                                 None   \n",
       "4                                                 None   \n",
       "..                                                 ...   \n",
       "275                                               None   \n",
       "276                                               None   \n",
       "277  {'attributes': [{'pmid': 25822367, 'descriptio...   \n",
       "278                                               None   \n",
       "279                                               None   \n",
       "\n",
       "                                              synonyms  ...  \\\n",
       "0    [{'label': 'Thyroid peroxidase', 'source': 'un...  ...   \n",
       "1    [{'label': 'Heat shock protein HSP 90-alpha', ...  ...   \n",
       "2    [{'label': '5-hydroxytryptamine receptor 6', '...  ...   \n",
       "3    [{'label': 'Ras-related protein Rab-9A', 'sour...  ...   \n",
       "4    [{'label': 'Adenosine receptor A2b', 'source':...  ...   \n",
       "..                                                 ...  ...   \n",
       "275  [{'label': 'Complement C4-A', 'source': 'unipr...  ...   \n",
       "276  [{'label': 'P2Y purinoceptor 2', 'source': 'un...  ...   \n",
       "277  [{'label': 'Menin', 'source': 'uniprot'}, {'la...  ...   \n",
       "278  [{'label': 'Inosine-5'-monophosphate dehydroge...  ...   \n",
       "279  [{'label': 'Peptidyl-prolyl cis-trans isomeras...  ...   \n",
       "\n",
       "                                         obsoleteNames  \\\n",
       "0                                                   []   \n",
       "1    [{'label': 'heat shock 90kD protein 1, alpha',...   \n",
       "2    [{'label': '5-hydroxytryptamine (serotonin) re...   \n",
       "3    [{'label': 'RAB9, member RAS oncogene family',...   \n",
       "4                                                   []   \n",
       "..                                                 ...   \n",
       "275  [{'label': 'complement component 4A', 'source'...   \n",
       "276  [{'label': 'purinergic receptor P2Y, G-protein...   \n",
       "277  [{'label': 'multiple endocrine neoplasia I', '...   \n",
       "278  [{'label': 'IMP (inosine 5'-monophosphate) deh...   \n",
       "279                                                 []   \n",
       "\n",
       "                                            constraint   tep  \\\n",
       "0    [{'constraintType': 'syn', 'score': -0.8653900...  None   \n",
       "1    [{'constraintType': 'syn', 'score': -8.6224002...  None   \n",
       "2    [{'constraintType': 'syn', 'score': -0.9145399...  None   \n",
       "3    [{'constraintType': 'syn', 'score': 0.95749002...  None   \n",
       "4    [{'constraintType': 'syn', 'score': 0.42638000...  None   \n",
       "..                                                 ...   ...   \n",
       "275  [{'constraintType': 'syn', 'score': 1.40649998...  None   \n",
       "276  [{'constraintType': 'syn', 'score': 0.44786998...  None   \n",
       "277  [{'constraintType': 'syn', 'score': 0.75444000...  None   \n",
       "278  [{'constraintType': 'syn', 'score': -0.9308099...  None   \n",
       "279  [{'constraintType': 'syn', 'score': -0.0022607...  None   \n",
       "\n",
       "                                            proteinIds  \\\n",
       "0    [{'id': 'P07202', 'source': 'uniprot_swissprot...   \n",
       "1    [{'id': 'P07900', 'source': 'uniprot_swissprot...   \n",
       "2    [{'id': 'P50406', 'source': 'uniprot_swissprot...   \n",
       "3    [{'id': 'P51151', 'source': 'uniprot_swissprot...   \n",
       "4    [{'id': 'P29275', 'source': 'uniprot_swissprot'}]   \n",
       "..                                                 ...   \n",
       "275  [{'id': 'P0C0L4', 'source': 'uniprot_swissprot...   \n",
       "276  [{'id': 'P41231', 'source': 'uniprot_swissprot...   \n",
       "277  [{'id': 'O00255', 'source': 'uniprot_swissprot...   \n",
       "278  [{'id': 'P12268', 'source': 'uniprot_swissprot...   \n",
       "279  [{'id': 'P62937', 'source': 'uniprot_swissprot...   \n",
       "\n",
       "                                               dbXrefs  \\\n",
       "0    [{'id': '12015', 'source': 'HGNC'}, {'id': 'CH...   \n",
       "1    [{'id': '5253', 'source': 'HGNC'}, {'id': '1BY...   \n",
       "2    [{'id': '5301', 'source': 'HGNC'}, {'id': 'CHE...   \n",
       "3    [{'id': '9792', 'source': 'HGNC'}, {'id': '1WM...   \n",
       "4    [{'id': '264', 'source': 'HGNC'}, {'id': 'CHEM...   \n",
       "..                                                 ...   \n",
       "275  [{'id': '1323', 'source': 'HGNC'}, {'id': '1HZ...   \n",
       "276  [{'id': '8541', 'source': 'HGNC'}, {'id': 'CHE...   \n",
       "277  [{'id': '7010', 'source': 'HGNC'}, {'id': '3U8...   \n",
       "278  [{'id': '6053', 'source': 'HGNC'}, {'id': '1B3...   \n",
       "279  [{'id': '9253', 'source': 'HGNC'}, {'id': '1AK...   \n",
       "\n",
       "                                        chemicalProbes  \\\n",
       "0                                                 None   \n",
       "1    [{'control': None, 'drugId': 'CHEMBL467399', '...   \n",
       "2                                                 None   \n",
       "3                                                 None   \n",
       "4    [{'control': None, 'drugId': None, 'id': 'MRS1...   \n",
       "..                                                 ...   \n",
       "275                                               None   \n",
       "276                                               None   \n",
       "277  [{'control': None, 'drugId': None, 'id': 'MI-2...   \n",
       "278  [{'control': None, 'drugId': None, 'id': 'BMS ...   \n",
       "279                                               None   \n",
       "\n",
       "                                            homologues  \\\n",
       "0    [{'speciesId': '9598', 'speciesName': 'Chimpan...   \n",
       "1    [{'speciesId': '9606', 'speciesName': 'Human',...   \n",
       "2    [{'speciesId': '9606', 'speciesName': 'Human',...   \n",
       "3    [{'speciesId': '9606', 'speciesName': 'Human',...   \n",
       "4    [{'speciesId': '9606', 'speciesName': 'Human',...   \n",
       "..                                                 ...   \n",
       "275  [{'speciesId': '9598', 'speciesName': 'Chimpan...   \n",
       "276  [{'speciesId': '9606', 'speciesName': 'Human',...   \n",
       "277  [{'speciesId': '9598', 'speciesName': 'Chimpan...   \n",
       "278  [{'speciesId': '9606', 'speciesName': 'Human',...   \n",
       "279  [{'speciesId': '9606', 'speciesName': 'Human',...   \n",
       "\n",
       "                                          tractability  \\\n",
       "0    [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "1    [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "2    [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "3    [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "4    [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "..                                                 ...   \n",
       "275  [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "276  [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "277  [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "278  [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "279  [{'modality': 'SM', 'id': 'Approved Drug', 'va...   \n",
       "\n",
       "                                     safetyLiabilities  \\\n",
       "0                                                 None   \n",
       "1                                                 None   \n",
       "2    [{'event': 'receptor binding', 'eventId': None...   \n",
       "3                                                 None   \n",
       "4    [{'event': 'increased/decreased inflammation',...   \n",
       "..                                                 ...   \n",
       "275                                               None   \n",
       "276                                               None   \n",
       "277                                               None   \n",
       "278                                               None   \n",
       "279                                               None   \n",
       "\n",
       "                                              pathways  \n",
       "0    [{'pathwayId': 'R-HSA-209968', 'pathway': 'Thy...  \n",
       "1    [{'pathwayId': 'R-HSA-9009391', 'pathway': 'Ex...  \n",
       "2    [{'pathwayId': 'R-HSA-418555', 'pathway': 'G a...  \n",
       "3    [{'pathwayId': 'R-HSA-8873719', 'pathway': 'RA...  \n",
       "4    [{'pathwayId': 'R-HSA-417973', 'pathway': 'Ade...  \n",
       "..                                                 ...  \n",
       "275  [{'pathwayId': 'R-HSA-977606', 'pathway': 'Reg...  \n",
       "276  [{'pathwayId': 'R-HSA-417957', 'pathway': 'P2Y...  \n",
       "277  [{'pathwayId': 'R-HSA-5626467', 'pathway': 'RH...  \n",
       "278  [{'pathwayId': 'R-HSA-6798695', 'pathway': 'Ne...  \n",
       "279  [{'pathwayId': 'R-HSA-114608', 'pathway': 'Pla...  \n",
       "\n",
       "[280 rows x 26 columns]"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#targetability[targetability['approvedSymbol']=='C1R']\n",
    "targetability.dropna(subset=['tractability'],inplace=True)\n",
    "targetability = targetability.reset_index(drop=True)\n",
    "targetability\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "id": "60671f23",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "RGS17\n",
      "C4B\n",
      "C5\n",
      "IFNA1\n",
      "IRF3\n",
      "KLRC3\n",
      "SERPINA6\n",
      "SLC7A11\n",
      "CCL26\n",
      "NAPRT\n",
      "TMEM97\n",
      "CD8A\n",
      "CD4\n",
      "CSNK2B\n",
      "ASAH1\n",
      "AHCYL1\n",
      "FUT7\n",
      "KLRK1\n",
      "CD46\n",
      "FABP3\n",
      "CD55\n",
      "OR10G6\n",
      "CYB5R3\n",
      "C4A\n",
      "MEN1\n"
     ]
    }
   ],
   "source": [
    "gene = []\n",
    "flag = []\n",
    "i = 0\n",
    "j = 0\n",
    "for i in range(len(targetability)):\n",
    "    #j = j+1\n",
    "    #print(j)\n",
    "#     if not targetability['tractability'][i]:\n",
    "#         continue\n",
    "        \n",
    "    #if pd.isna(targetability['tractability'][i].any() != True): \n",
    "    if targetability['tractability'][i][7]['value'] == True:\n",
    "        #i = i+1\n",
    "        #print(i)\n",
    "        #print(targetability['tractability'][i])\n",
    "        #print(targetability['approvedSymbol'][i])\n",
    "        #print(targetability['tractability'][i][7]['value'])\n",
    "        gene.append(targetability['approvedSymbol'][i])\n",
    "        flag.append('Yes')\n",
    "        \n",
    "    else:\n",
    "        print(targetability['approvedSymbol'][i])\n",
    "        gene.append(targetability['approvedSymbol'][i])\n",
    "        flag.append('No')\n",
    "\n",
    "        "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "id": "67d8f8fb",
   "metadata": {},
   "outputs": [],
   "source": [
    "druggability = pd.DataFrame()\n",
    "druggability['Gene'] = gene\n",
    "druggability['Druggable Family'] = flag\n",
    "druggability.to_csv('data/normalized_data/druggability.csv',sep=',')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "2b0ba0aa",
   "metadata": {},
   "outputs": [],
   "source": [
    "if targetability['tractability'][144].any():\n",
    "    print('ok')\n",
    "    targetability['tractability'][144]\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "45eb39bf",
   "metadata": {},
   "outputs": [],
   "source": [
    "if targetability['tractability'][144].any:\n",
    "    print(targetability['tractability'][144])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "fb1596e2",
   "metadata": {},
   "outputs": [],
   "source": [
    "pd.isna(targetability['tractability'][144]) != True"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "5e65baa4",
   "metadata": {},
   "outputs": [],
   "source": [
    "targetability['tractability'][144]\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "97f8a275",
   "metadata": {},
   "outputs": [],
   "source": [
    "pybel.to_graphml(mpox_graph,'data/normalized_data/Monkeypox_KG_20thJuly.graphml')\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "8b579f2e",
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "e9a8a247",
   "metadata": {},
   "outputs": [],
   "source": [
    "sns.set_theme(style=\"whitegrid\")\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "36d9798b",
   "metadata": {},
   "outputs": [],
   "source": [
    "tips"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "aecbe56b",
   "metadata": {},
   "outputs": [],
   "source": [
    "node_data = {'Node':['Pathology','BiologicalProcess','Abundance','Protein'],\n",
    "       'Number':[3347,2068,1420,381]}\n",
    "node = pd.DataFrame(node_data)\n",
    "a = sns.barplot(x=\"Node\", y=\"Number\", data=node)\n",
    "a.set(xlabel='Node',ylabel='Number',title= 'KG nodes in numbers (Total=7216)')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "b200742e",
   "metadata": {},
   "outputs": [],
   "source": [
    "nspace_data = {'Namespace':['ChEMBLAssay','ChEMBL','GOBP','GOMF','Protein','Disease','SideEffect','Reactome','MOA'],\n",
    "       'Number':[862,558,774,537,381,36,3311,751,6]}\n",
    "nspace = pd.DataFrame(nspace_data)\n",
    "a = sns.barplot(x=\"Number\", y=\"Namespace\", data=nspace_data)\n",
    "a.set(xlabel='Number',ylabel='Namespace',title= 'KG Namespace in numbers')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "5be2a659",
   "metadata": {},
   "outputs": [],
   "source": []
  }
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