blood-metabolites-regulation

This repository contains the analysis scripts for the study, Reconstructing the blood metabolome and genotype using long-range chromatin interactions¹. The study identifies target genes of 130 genetic variants that modulate about 400 blood metabolites² using chromatin interactions (from Hi-C)³ and expression quantitative trait loci (eQTL)⁴ data.

References

1. Fadason, T. et al. Reconstructing the blood metabolome and genotype using long-range chromatin interactions. BiorXiv, (2019).
2. Shin, S.-Y. et al. An atlas of genetic influences on human blood metabolites. Nat. Genet. 46, 543–550 (2014).
3. Rao, S. S. P. et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159, 1665–1680 (2014).
4. Ardlie, K. G. et al. The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans. Science (80-. ). 348, 648–660 (2015).