diff --git a/Project.toml b/Project.toml
index 47a91f0c..d25d100a 100644
--- a/Project.toml
+++ b/Project.toml
@@ -1,6 +1,6 @@
 name = "Gtk4"
 uuid = "9db2cae5-386f-4011-9d63-a5602296539b"
-version = "0.6.5"
+version = "0.6.6"
 
 [deps]
 BitFlags = "d1d4a3ce-64b1-5f1a-9ba4-7e7e69966f35"
@@ -33,20 +33,20 @@ Cairo = "1.0.0"
 Cairo_jll = "1.16.0"
 ColorTypes = "0.10, 0.11"
 FixedPointNumbers = "0.5, 0.6, 0.7, 0.8"
-GTK4_jll = "4.6.0"
-Glib_jll = "2.74.0"
+GTK4_jll = "4.12.0"
+Glib_jll = "2.78.0"
 Graphene_jll = "1.10"
 Graphics = "1"
 JLLWrappers = "1.4.0"
 Libdl = "1.6"
 libpng_jll = "<1.6.42"
 Librsvg_jll = "2.54"
-Pango_jll = "1.50"
+Pango_jll = "1.51"
 Preferences = "1"
 Reexport = "1.0"
 Scratch = "1.1.0"
 Xorg_xkeyboard_config_jll = "2.27.0"
 adwaita_icon_theme_jll = "3,43"
-gdk_pixbuf_jll = "2.38.2"
+gdk_pixbuf_jll = "2.42.0"
 hicolor_icon_theme_jll = "0.17.0"
 julia = "1.6"
diff --git a/src/GLib/GLib.jl b/src/GLib/GLib.jl
index f1a9c369..38a659e0 100644
--- a/src/GLib/GLib.jl
+++ b/src/GLib/GLib.jl
@@ -202,6 +202,11 @@ include("gio.jl")
 
 const exiting = Ref(false)
 function __init__()
+    # check that libglib is compatible with what the GI generated code expects
+    vercheck = G_.check_version(MAJOR_VERSION,MINOR_VERSION,0)
+    if vercheck !== nothing
+        @warn "GLib version check failed: $vercheck"
+    end
     global JuliaClosureMarshal = @cfunction(GClosureMarshal, Nothing,
         (Ptr{Nothing}, Ptr{GValue}, Cuint, Ptr{GValue}, Ptr{Nothing}, Ptr{Nothing}))
     exiting[] = false
diff --git a/src/Gtk4.jl b/src/Gtk4.jl
index f35f24cd..6d361e7e 100644
--- a/src/Gtk4.jl
+++ b/src/Gtk4.jl
@@ -125,6 +125,12 @@ end
 function __init__()
     in("Gtk",[x.name for x in keys(Base.loaded_modules)]) && error("Gtk4 is incompatible with Gtk.")
 
+    # check that GTK is compatible with what the GI generated code expects
+    vercheck = G_.check_version(MAJOR_VERSION,MINOR_VERSION,0)
+    if vercheck !== nothing
+        @warn "Gtk4 version check failed: $vercheck"
+    end
+
     # Set XDG_DATA_DIRS so that Gtk can find its icons and schemas
     ENV["XDG_DATA_DIRS"] = join(filter(x -> x !== nothing, [
         dirname(adwaita_icons_dir),
diff --git a/src/Pango/Pango.jl b/src/Pango/Pango.jl
index d6ffff07..e0998cf1 100644
--- a/src/Pango/Pango.jl
+++ b/src/Pango/Pango.jl
@@ -55,8 +55,13 @@ for func in filter(x->startswith(string(x),"set_"),Base.names(G_,all=true))
 end
 
 function __init__()
-   gtype_wrapper_cache_init()
-   gboxed_cache_init()
+    # check that libpango is compatible with what the GI generated code expects
+    vercheck = G_.version_check(VERSION_MAJOR,VERSION_MINOR,0)
+    if vercheck !== nothing
+        @warn "Pango version check failed: $vercheck"
+    end
+    gtype_wrapper_cache_init()
+    gboxed_cache_init()
 end
 
 default_font_map() = G_.font_map_get_default()