MRC Network project

This repo has the code for the MRC network multi-ancestry drug MR project.

Organisation

data_generation - use this folder for the per-study / per-ancestry phenotype harmonisation and GWAS analysis scripts
analysis - use this folder for the upstream and downstream analysis components of the project (e.g. using the GWAS results for downstream analysis)

Analysis

Genome-wide association analyses

Phenotypes of interest:

LDL cholesterol
HDL cholesterol
Triglycerides
Systolic blood pressure
Diastolic blood pressure
Pulse pressure
Coronary heart disease
Hypertension
Stroke

Data source	Ancestry	GWAS software
UK Biobank	AFR	GENESIS
	EAS	GENESIS
	EUR	BOLT-LMM
	SAS	GENESIS
Ugandan Genome Resource	Continental AFR	GENESIS

Meta-analyses using METAL

Analysis:

Inverse variance weighted approach weighted on sample size

Comparison of effects across ancestry

Analysis: