diff --git a/ui/pages/confirmations/components/confirm/footer/footer.test.tsx b/ui/pages/confirmations/components/confirm/footer/footer.test.tsx
index 5fb6b7e5ac76..4122f82028e4 100644
--- a/ui/pages/confirmations/components/confirm/footer/footer.test.tsx
+++ b/ui/pages/confirmations/components/confirm/footer/footer.test.tsx
@@ -88,11 +88,23 @@ describe('ConfirmFooter', () => {
       // TODO: Replace `any` with type
       // eslint-disable-next-line @typescript-eslint/no-explicit-any
       .mockImplementation(() => ({} as any));
+    const updateCustomNonceSpy = jest
+      .spyOn(Actions, 'updateCustomNonce')
+      // TODO: Replace `any` with type
+      // eslint-disable-next-line @typescript-eslint/no-explicit-any
+      .mockImplementation(() => ({} as any));
+    const setNextNonceSpy = jest
+      .spyOn(Actions, 'setNextNonce')
+      // TODO: Replace `any` with type
+      // eslint-disable-next-line @typescript-eslint/no-explicit-any
+      .mockImplementation(() => ({} as any));
     fireEvent.click(cancelButton);
     expect(rejectSpy).toHaveBeenCalled();
+    expect(updateCustomNonceSpy).toHaveBeenCalledWith('');
+    expect(setNextNonceSpy).toHaveBeenCalledWith('');
   });
 
-  it('invoke action resolvePendingApproval when submit button is clicked', () => {
+  it('invoke required actions when submit button is clicked', () => {
     const { getAllByRole } = render();
     const submitButton = getAllByRole('button')[1];
     const resolveSpy = jest
@@ -100,8 +112,20 @@ describe('ConfirmFooter', () => {
       // TODO: Replace `any` with type
       // eslint-disable-next-line @typescript-eslint/no-explicit-any
       .mockImplementation(() => ({} as any));
+    const updateCustomNonceSpy = jest
+      .spyOn(Actions, 'updateCustomNonce')
+      // TODO: Replace `any` with type
+      // eslint-disable-next-line @typescript-eslint/no-explicit-any
+      .mockImplementation(() => ({} as any));
+    const setNextNonceSpy = jest
+      .spyOn(Actions, 'setNextNonce')
+      // TODO: Replace `any` with type
+      // eslint-disable-next-line @typescript-eslint/no-explicit-any
+      .mockImplementation(() => ({} as any));
     fireEvent.click(submitButton);
     expect(resolveSpy).toHaveBeenCalled();
+    expect(updateCustomNonceSpy).toHaveBeenCalledWith('');
+    expect(setNextNonceSpy).toHaveBeenCalledWith('');
   });
 
   it('displays a danger "Confirm" button there are danger alerts', async () => {
diff --git a/ui/pages/confirmations/components/confirm/footer/footer.tsx b/ui/pages/confirmations/components/confirm/footer/footer.tsx
index 6c70277b7ba5..e0d61f66f421 100644
--- a/ui/pages/confirmations/components/confirm/footer/footer.tsx
+++ b/ui/pages/confirmations/components/confirm/footer/footer.tsx
@@ -22,7 +22,11 @@ import useAlerts from '../../../../../hooks/useAlerts';
 import {
   rejectPendingApproval,
   resolvePendingApproval,
+  setNextNonce,
+  ///: BEGIN:ONLY_INCLUDE_IF(build-main,build-beta,build-flask)
   updateAndApproveTx,
+  ///: END:ONLY_INCLUDE_IF
+  updateCustomNonce,
 } from '../../../../../store/actions';
 import { confirmSelector } from '../../../selectors';
 import { REDESIGN_DEV_TRANSACTION_TYPES } from '../../../utils';
@@ -156,6 +160,8 @@ const Footer = () => {
       dispatch(
         rejectPendingApproval(currentConfirmation.id, serializeError(error)),
       );
+      dispatch(updateCustomNonce(''));
+      dispatch(setNextNonce(''));
     },
     [currentConfirmation],
   );
@@ -186,6 +192,8 @@ const Footer = () => {
       mmiOnSignCallback();
       ///: END:ONLY_INCLUDE_IF
     }
+    dispatch(updateCustomNonce(''));
+    dispatch(setNextNonce(''));
   }, [currentConfirmation, customNonceValue]);
 
   const onFooterCancel = useCallback(() => {
diff --git a/ui/pages/confirmations/confirm-transaction-base/confirm-transaction-base.component.js b/ui/pages/confirmations/confirm-transaction-base/confirm-transaction-base.component.js
index 5330a3685d47..f344a9392455 100644
--- a/ui/pages/confirmations/confirm-transaction-base/confirm-transaction-base.component.js
+++ b/ui/pages/confirmations/confirm-transaction-base/confirm-transaction-base.component.js
@@ -134,6 +134,7 @@ export default class ConfirmTransactionBase extends Component {
     image: PropTypes.string,
     type: PropTypes.string,
     getNextNonce: PropTypes.func,
+    setNextNonce: PropTypes.func,
     nextNonce: PropTypes.number,
     tryReverseResolveAddress: PropTypes.func.isRequired,
     hideSenderToRecipient: PropTypes.bool,
@@ -696,12 +697,14 @@ export default class ConfirmTransactionBase extends Component {
       history,
       mostRecentOverviewPage,
       updateCustomNonce,
+      setNextNonce,
     } = this.props;
 
     this._removeBeforeUnload();
-    updateCustomNonce('');
     await cancelTransaction(txData);
     history.push(mostRecentOverviewPage);
+    updateCustomNonce('');
+    setNextNonce('');
   }
 
   handleSubmit() {
@@ -723,6 +726,7 @@ export default class ConfirmTransactionBase extends Component {
       history,
       mostRecentOverviewPage,
       updateCustomNonce,
+      setNextNonce,
       methodData,
       maxFeePerGas,
       customTokenAmount,
@@ -786,6 +790,9 @@ export default class ConfirmTransactionBase extends Component {
 
         sendTransaction(txData, false, loadingIndicatorMessage)
           .then(() => {
+            updateCustomNonce('');
+            setNextNonce('');
+
             if (!this._isMounted) {
               return;
             }
@@ -796,11 +803,12 @@ export default class ConfirmTransactionBase extends Component {
               },
               () => {
                 history.push(mostRecentOverviewPage);
-                updateCustomNonce('');
               },
             );
           })
           .catch((error) => {
+            updateCustomNonce('');
+            setNextNonce('');
             if (!this._isMounted) {
               return;
             }
@@ -808,7 +816,6 @@ export default class ConfirmTransactionBase extends Component {
               submitting: false,
               submitError: error.message,
             });
-            updateCustomNonce('');
           });
       },
     );
@@ -822,6 +829,7 @@ export default class ConfirmTransactionBase extends Component {
       history,
       mostRecentOverviewPage,
       updateCustomNonce,
+      setNextNonce,
       unapprovedTxCount,
       accountType,
       isNotification,
@@ -894,6 +902,8 @@ export default class ConfirmTransactionBase extends Component {
 
         sendTransaction(txData)
           .then(() => {
+            updateCustomNonce('');
+            setNextNonce('');
             if (txData.custodyStatus) {
               showCustodianDeepLink({
                 fromAddress,
@@ -912,7 +922,6 @@ export default class ConfirmTransactionBase extends Component {
                   }
                   this.setState({ submitting: false }, () => {
                     history.push(mostRecentOverviewPage);
-                    updateCustomNonce('');
                   });
                 },
               });
@@ -926,12 +935,14 @@ export default class ConfirmTransactionBase extends Component {
                 },
                 () => {
                   history.push(mostRecentOverviewPage);
-                  updateCustomNonce('');
                 },
               );
             }
           })
           .catch((error) => {
+            updateCustomNonce('');
+            setNextNonce('');
+
             if (!this._isMounted) {
               return;
             }
@@ -943,7 +954,6 @@ export default class ConfirmTransactionBase extends Component {
               submitError: error.message,
             });
             setWaitForConfirmDeepLinkDialog(true);
-            updateCustomNonce('');
           });
       },
     );
diff --git a/ui/pages/confirmations/confirm-transaction-base/confirm-transaction-base.container.js b/ui/pages/confirmations/confirm-transaction-base/confirm-transaction-base.container.js
index cc3de6095f2d..0efa6fe9c58b 100644
--- a/ui/pages/confirmations/confirm-transaction-base/confirm-transaction-base.container.js
+++ b/ui/pages/confirmations/confirm-transaction-base/confirm-transaction-base.container.js
@@ -29,6 +29,7 @@ import {
   updateEditableParams,
   setSwapsFeatureFlags,
   fetchSmartTransactionsLiveness,
+  setNextNonce,
 } from '../../../store/actions';
 import { isBalanceSufficient } from '../send/send.utils';
 import { shortenAddress, valuesFor } from '../../../helpers/utils/util';
@@ -429,6 +430,7 @@ export const mapDispatchToProps = (dispatch) => {
       dispatch(fetchSmartTransactionsLiveness());
     },
     getNextNonce: () => dispatch(getNextNonce()),
+    setNextNonce: (val) => dispatch(setNextNonce(val)),
     setDefaultHomeActiveTabName: (tabName) =>
       dispatch(setDefaultHomeActiveTabName(tabName)),
     updateTransactionGasFees: (gasFees) => {