GitHub - ModelDBRepository/184054: CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)

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CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)

modeldb.science/184054

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Name		Name	Last commit message	Last commit date
Latest commit History 2 Commits
commonFcns		commonFcns
fullMorphCaLTP8		fullMorphCaLTP8
mosinit.hoc		mosinit.hoc
readme.html		readme.html
screenshot1.png		screenshot1.png
screenshot2.png		screenshot2.png

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<html><pre>
This is the readme for the model associated with the paper:

Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N (2015) Dendritic
sodium spikes are required for long-term potentiation at distal
synapses on hippocampal pyramidal neurons. Elife

This model was adapted based on previously published models (as
described in the paper). The neuron was reconstructed from a
55-day-old male rat.

This model requires NEURON which is freely available at
<a href="http://www.neuron.yale.edu">http://www.neuron.yale.edu</a>.

Usage:

Auto-launch from modeldb or download and extract the model.  Compile
the mod files in fullMorphCaLTP8 subfolder with nrnivmodl (unix/linux)
or mknrndll (mswin or max os x).  Use "start.hoc" to start the program
("nrngui start.hoc" on unix/linux, double click start.hoc in windows
explorer (mswin), or drag and drop start.hoc onto the nrngui icon
(mac)).

After the simulation runs for a couple of minutes you should see the
following figures which are similar to those in figure 8 in the paper:

<img src="./screenshot1.png" alt="screenshot1" width="550">
<img src="./screenshot2.png" alt="screenshot2" width="550">

Questions can be directed to Ching-Lung Hsu (hsuc at
janelia.hhmi.org), Mark Cembrowski (cembrowskim at janelia.hhmi.org)
or Nelson Spruston (sprustonn at janelia.hhmi.org).

20150830 New version supplied by Ching-Lung Hsu corrects typos and
simplifies init.hoc to omit caimax.mod, caiPeaks.mod, and vmax.mod
from model.
</pre></html>