Two versions of the model of an un-myelinated, C-fiber sensory neuron from:
Sundt D, Gamper N, and Jaffe DB. Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study. J Neurophysiol. 2015 Dec 1;114(6):3140-53. doi:10.1152/jn.00226.2015
The two versions, located in separate folders, generate Figures 5d and 8c. Figure5d varies M-channel density and illustrates where the reflecting spike generated. Figure8c illustrates the effect of the Na/K pump on membrane potential and spike failure at the T-junction.
Here is a sketch of how to run the programs. There is more help available at https://modeldb.science/NEURON_DwnldGuide.
-
Compile the ".mod files" within the mods folder.
-
For each version of the model, compile the mod files within the mod folder (
Figure5d/mods
&Figure8c/mods
). -
For either version (
Figure5d.hoc
orFigure8c.hoc
), run the simulation using the "special" executable. -
Data output,
Fig5doutput.dat
orFig8coutput.dat
, can be viewed using the python scripts provided (Plot5d.py
andPlot8c.py
, respectively). You should see the following graphs:
2024-10-01 Updated links and converted readme to markdown