GitHub - ModelDBRepository/245417: Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)

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Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)

modeldb.science/245417

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Name		Name	Last commit message	Last commit date
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README.html		README.html
cacumm.mod		cacumm.mod
can2t.mod		can2t.mod
fig4_modeldb.hoc		fig4_modeldb.hoc
fig4_modeldb.ses		fig4_modeldb.ses
kaprox.mod		kaprox.mod
kdrca1.mod		kdrca1.mod
kir.mod		kir.mod
kmb.mod		kmb.mod
mosinit.hoc		mosinit.hoc
naxn_J.mod		naxn_J.mod
screenshot1.png		screenshot1.png
screenshot2.png		screenshot2.png

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<html>
<p>Model
files in the NEURON simulation environment (v7.5) from the paper:</p>
<p><b>The
subthreshold-active Kv7 current limits spike-induced Ca2+
influx in hippocampal mossy fiber synaptic terminals to regulate
neurotransmission.”</b></p>
<p>By
Katiuscia Martinello , Elisabetta Giacalone , Michele Migliore ,
David A. Brown and Mala M. Shah</p>
<p>Communications
Biology, 2019</p>
<p></p>
<p>Auto-launch
from ModelDB or:</p>
<p>Compile
the mod files with mknrndll (mswin or graphical mac) or nrnivmodl
(unix/linux)). Start the simulation by (unix/linux) typing on the
command line:</p>
<p>nrngui
mosinit.hoc</p>
<p>or
(mac os x) drag and dropping the mosinit.hoc file on the nrngui icon
or (mswin) double clicking on the mosinit.hoc file.</p>
<p><br/>
<br/>

</p>
<p>Select
“Single AP” or “50 Hz train” to reproduce respectively
figures 4b,c and d of the paper.</p>
<p>The
simulations will reproduce functional effects of Km removal in mossy
fiber boutons.</p>
<p><br/>
  After you press the "Single AP" button you should see images like these:<p/>
  <img src="./screenshot1.png" alt="screenshot 1"><p/>
  and after you press "50 Hz train" you should see the below:<p/>
  <img src="./screenshot2.png" alt="screenshot 2"><p/>
  If you need more help running the model on your platform, please consult this page:<p/>
  <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a>
 
<br/>
</p>
</html>