vc_demo.hoc

// vc_demo.hoc
// demonstrates the six-state Na current model in voltage clamp from
// Baranauskas and Martina 2006 J Neurosci 26(2):671-684

// soma is used as a patch of membrane to insert Na model
create soma
access soma

insert MCna1

Na_extern_MCna1=10
Na_intern_MCna1=34

objref VC
soma VC = new VClamp(0.5)

VC.amp[0]=-76
VC.amp[1]=-116
VC.amp[2]=-36
VC.dur[0]=100
VC.dur[1]=70
VC.dur[2]=70
tstop = 240

objref g1, g2
g1 = new Graph()
g1.exec_menu("Keep Lines")
g2 = new Graph()
g2.exec_menu("Keep Lines")

objref cur, t_vec, x, y
cur = new Vector()   // record the Na current
t_vec = new Vector() // record the time steps

cur.record(&soma.ina_MCna1(0.5))
t_vec.record(&t)

celsius = 12

first_stop = int((VC.dur[0]+VC.dur[1])/dt)
last_stop = tstop/dt

for i=1,8 { 
	init() 
	run() 
	x = t_vec.c(0,first_stop)
	y = cur.c(0,first_stop)
	y.line(g1,x)

	x = t_vec.c(first_stop,last_stop)
	y = cur.c(first_stop,last_stop)
	y.line(g2,x)
	VC.amp[1] += 10
}

g1.exec_menu("View = plot")
g2.exec_menu("View = plot")