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Team-10_database.html
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Team-10_database.html
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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>cEpiReg: A Database for TF-gene-CRE regulations and their implications in Alzheimer's disease genetics - Revealing the hidden link</title>
<link rel="stylesheet" href="styles.css">
<link href="https://fonts.googleapis.com/css2?family=Montserrat:wght@400;700&family=Open+Sans:wght@400;700&display=swap" rel="stylesheet">
<style>
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</style>
</head>
<body>
<header>
<div class="container">
<div class="logo-container">
<div class="logo">
<img class="db-logo" src="/images/students_24/neharao/NR-biorender-cepireg-logo.png" alt="db Logo">
</div>
<div class="logo-text">
<h2>Context-specific epigenetic regulatory network database</h2>
<h3>A Database for TF-gene-CRE regulations and their implications in Alzheimer's disease genetics</h3>
</div>
</div>
<nav>
<ul>
<li><a class="menu__item" href="Team-10_database.html">Home</a></li>
<li><a class="menu__item" href="GRN-test.html">GRN</a></li>
<li><a class="menu__item" href="ATAC.html">CRE Explorer</a></li>
<li><a class="menu__item" href="eQTL-data.html">CRE + genes</a></li>
<li><a class="menu__item" href="help.html">Help Page</a></li>
<li><a class="menu__item" href="https://hougroup.xyz/" target="_blank">Hou Lab</a></li>
</ul>
</nav>
</div>
</header>
<main>
<div class="container">
<section class="video-section">
<video width="100%" controls>
<source src="/images/students_24/Team_10/Database_Overview.mp4" type="video/mp4">
Your browser does not support the video tag.
</video>
<section class="content">
<p>cEpiReg constructs a comprehensive database elucidating the intricate regulatory mechanisms underlying Alzheimer's Disease (AD) genetics.Through integrating data from scRNA seq and sc-ATAC seq, we identified the cis-regulatory elements (CREs) by comparing our results against various databases like ENCODE, Epimap, GWAS Catalog, and publicly available datasets. This project establishes a robust framework connecting transcription factors (TFs), CREs, and target genes. cEpiReg uncovers hidden regulatory links that could piece together missing links crucial for understanding AD pathogenesis.</p>
<p>The cEpiReg Database was developed at Boston University as part of BF768, Spring 2024 course, under the instruction of Dr Gary Benson, Dr Lei Hou and Dr Ting-Ting Fu.</p>
</section>
</div>
</main>
<footer>
<div class="container">
<h2>Website and database created by Neha Rao, Bhavana Kapalli, and Jawahar Mahendran</h2>
</div>
<div class="container contact">
<h3>Contact Us</h3>
<hr>
<p>Principal Investigator: Lei Hou, Ph.D.<br>
Section of Biomedical Genetics, Department of Medicine,<br>
Boston University Chobanian & Avedisian School of Medicine<br>
Email: LeiHou@BU.Edu</p>
</div>
</footer>
</body>
</html>