diff --git a/pkgs/development/python-modules/pylsl/default.nix b/pkgs/development/python-modules/pylsl/default.nix
new file mode 100644
index 0000000000000..f58a67956e36a
--- /dev/null
+++ b/pkgs/development/python-modules/pylsl/default.nix
@@ -0,0 +1,43 @@
+{
+  lib,
+  liblsl,
+  fetchFromGitHub,
+  buildPythonPackage,
+  setuptools,
+  wheel,
+}:
+
+buildPythonPackage rec {
+  pname = "pylsl";
+  version = "1.16.2";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "labstreaminglayer";
+    repo = "pylsl";
+    rev = "v${version}";
+    hash = "sha256-rReoPirf1rdQppKEBfHMk3J2htdsnFfIdlNQIprOoUg=";
+  };
+
+  postPatch = ''
+    substituteInPlace pylsl/pylsl.py \
+      --replace "def find_liblsl_libraries(verbose=False):" "$(echo -e "def find_liblsl_libraries(verbose=False):\n    yield '${liblsl}/lib/liblsl.so'")"
+  '';
+
+  nativeBuildInputs = [
+    setuptools
+    wheel
+  ];
+
+  buildImputs = [ liblsl ];
+
+  pythonImportsCheck = [ "pylsl" ];
+
+  meta = with lib; {
+    description = "Python bindings (pylsl) for liblsl";
+    homepage = "https://github.com/labstreaminglayer/pylsl";
+    license = licenses.mit;
+    maintainers = with maintainers; [ abcsds ];
+    mainProgram = "pylsl";
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index edde228999dde..e62b76bd072f5 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10264,6 +10264,8 @@ self: super: with self; {
 
   pyloadapi = callPackage ../development/python-modules/pyloadapi { };
 
+  pylsl = callPackage ../development/python-modules/pylsl { };
+
   pyngo = callPackage ../development/python-modules/pyngo { };
 
   pyngrok = callPackage ../development/python-modules/pyngrok { };