RNaseViz is a web-based application built with R Shiny, providing an interactive platform for visualizing RNase sequences, their conservation across different species, and the mutations associated with Mendelian diseases. https://norreanea.shinyapps.io/RNaseViz/
- Selection of RNase enzymes from a predefined list.
- Visualization of sequence conservation using multiple sequence alignments.
- Interactive phylogenetic trees illustrating evolutionary relationships.
- Highlighting specific mutations and their positions within the sequences.
- Support for various RNase enzymes with associated Mendelian disease mutations.
To use the RNaseViz application:
- Visualize: From the dropdown menu labeled "Choose RNase:", select the RNase enzyme you wish to analyze and click the 'Visualize' button.
- Highlight Mutation: Use the "Select organism:" dropdown to choose the organism of interest, enter a position number in the reference sequence, and click 'Highlight position' to view specific mutations.
- RNase info: Provides in-depth information about the selected RNase enzyme, including the potential molecular consequences of its mutations.
- Residue Highlighting: Highlights the specified residue within the sequence alignment, along with the two adjacent residues on either side, to emphasize key positions.
- Explore Tree: The displayed tree structure allows you to explore how different RNase sequences relate to different species.
- Inspect Residues: Select and highlight any residue within the sequence alignment for detailed examination and analysis.
- Download Global Alignment: Download sequence alignments in FASTA or PDF formats for offline analysis.
For questions or support, please open an issue on this GitHub repository.