v1.0.0 - Initial Release
RNaseViz is a web-based application built with R Shiny, providing an interactive platform for visualizing RNase sequences, their conservation across different species, and the mutations associated with Mendelian diseases.
Features
- Selection of RNase enzymes: Users can select RNase enzymes from a predefined list.
- Sequence Conservation Visualization: Visualize sequence conservation using multiple sequence alignments.
- Interactive Phylogenetic Trees: Illustrates evolutionary relationships.
- Mutation Highlighting: Highlights specific mutations and their positions within the sequences.
- Support for Various RNase Enzymes: Includes associated Mendelian disease mutations.
Usage
- Select RNase: Choose an RNase enzyme from the dropdown menu to begin the analysis.
- Visualize: Click the 'Visualize' button to load the sequence data and related visualizations.
- Highlight Mutation: Enter a position number in the human reference sequence and click 'Highlight position' to view specific mutations.
- Explore Tree: Click on different parts of the phylogenetic tree to see detailed evolutionary relationships.
- Inspect Mutations: The sequence visualization will show highlighted regions corresponding to entered mutations.
Bug Fixes
- Initial release, no prior bugs to fix.
Improvements
- Initial release, no prior improvements.
Breaking Changes
- None
Known Issues
- Visualization may not support all sequence formats.
- Some interactive features may not work on older browsers.
Contact
For questions or support, please open an issue on this GitHub repository.
Note: This is the initial release of the RNaseViz application. Future updates will include additional features and improvements based on user feedback.