Pediatric Qualification Package for CYP3A4 Ontogeny

In this repository the electronic package for qualification of CYP3A4 ontogeny using in vivo probe substances are stored, including

• Input files

For the Qualification of the CYP3A4 mediated elimination of compounds, the following probe substances were included:

• Alfentanil [1]
• Sufentanil [2]

Necessary software to execute the qualification workflow (see http://setup.open-systems-pharmacology.org for download links and instructions):

• QualificationRunner
• Reporting-Engine
• Markdown-joiner

References

[1] Alfentanil-Model, Whole-body PBPK model of Alfentanil.

[2] Sufentanil-Model, Whole-body PBPK model of Sufentanil.