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fix spellcheck and convert hyperlinks to lowcase (#15)
* fix spellcheck and convert hyperlinks to lowcase * fix spellcheck and convert hyperlinks to lowcase * fix spellcheck and convert hyperlinks to lowcase Co-authored-by: Yuri05 <Yuri05@github.com>
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The release of the snapshot containing the respective simulations can be found here: | ||
https://github.com/Open-Systems-Pharmacology/Cimetidine-Alfentanil-DDI/releases/tag/v1.1. | ||
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The cimetidine-alfentanil interaction was evaluated using a single clinical DDI study quantifying the interaction following two different dosing regimens ([Kienlen 1993](#4-References)). | ||
The cimetidine-alfentanil interaction was evaluated using a single clinical DDI study quantifying the interaction following two different dosing regimens ([Kienlen 1993](#4-references)). | ||
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| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study | | ||
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- | | ||
| 1344 | CYP3A4 | Cimetidine / alfentanil | Cimetidine: 1200 mg iv OD over 3 days<br />Alfentanil: 125 µg/kg iv on day 3 concomitantly with the cimetidine dose | No cross-over study! Parallel group design -> the two groups may not really be comparable given the low number of subjects and considering alfentanil PK variability | [Kienlen 1993](#4-References) | | ||
| 1344 | CYP3A4 | Cimetidine / alfentanil | Cimetidine: 1200 mg iv OD over 3 days<br />Alfentanil: 125 µg/kg iv on day 3 concomitantly with the cimetidine dose | No cross-over study! Parallel group design -> the two groups may not really be comparable given the low number of subjects and considering alfentanil PK variability | [Kienlen 1993](#4-references) | | ||
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The release of the snapshot containing the respective simulations can be found here: | ||
https://github.com/Open-Systems-Pharmacology/Cimetidine-Alprazolam-DDI/releases/tag/v1.1. | ||
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The cimetidine-alprazolam interaction was evaluated using two clinical DDI studies quantifying the interaction following two different dosing regimens ([Pourbaix 1985](#4-References), [Abernethy 1983](#4-References)). | ||
The cimetidine-alprazolam interaction was evaluated using two clinical DDI studies quantifying the interaction following two different dosing regimens ([Pourbaix 1985](#4-references), [Abernethy 1983](#4-references)). | ||
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| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study | | ||
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- | | ||
| 1340 | CYP3A4 | Cimetidine / alprazolam | Cimetidine: 200 mg po TID and 400 mg at bedtime over two weeks<br />Alprazolam: 0.5 mg po OD in the second week concomitantly with morning dose | | [Pourbaix 1985](#4-References) | | ||
| 1332 | CYP3A4 | Cimetidine / alprazolam | Cimetidine: 300 mg po QID (4 times)<br />Alprazolam: 1 mg po single dose concomitantly with cimetidine dose at 12 h | | [Abernethy 1983](#4-References) | | ||
| 1340 | CYP3A4 | Cimetidine / alprazolam | Cimetidine: 200 mg po TID and 400 mg at bedtime over two weeks<br />Alprazolam: 0.5 mg po OD in the second week concomitantly with morning dose | | [Pourbaix 1985](#4-references) | | ||
| 1332 | CYP3A4 | Cimetidine / alprazolam | Cimetidine: 300 mg po QID (4 times)<br />Alprazolam: 1 mg po single dose concomitantly with cimetidine dose at 12 h | | [Abernethy 1983](#4-references) | | ||
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The release of the snapshot containing the respective simulations can be found here: | ||
https://github.com/Open-Systems-Pharmacology/Cimetidine-Midazolam-DDI/releases/tag/v1.1. | ||
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The cimetidine-midazolam interaction was evaluated using five clinical DDI studies quantifying the interaction following six different dosing regimens ([Elliott 1984](#4-References), [Fee 1987](#4-References), [Greenblatt 1986](#4-References), [Martinez 1999](#4-References), [Salonen 1986](#4-References)). | ||
The cimetidine-midazolam interaction was evaluated using five clinical DDI studies quantifying the interaction following six different dosing regimens ([Elliott 1984](#4-references), [Fee 1987](#4-references), [Greenblatt 1986](#4-references), [Martinez 1999](#4-references), [Salonen 1986](#4-references)). | ||
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| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study | | ||
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- | | ||
| 1346 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 200 mg po TID and 400 mg nocte on day before study and 200 mg on study day <br />Midazolam: 7.5 mg po single dose, 2.5 hours after last cimetidine dose | | [Elliott 1984](#4-References) | | ||
| 1324 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 400 mg po BID (3 times)<br />Midazolam: 15 mg po single dose, 1 hour after the last cimetidine dose | | [Fee 1987](#4-References) | | ||
| 1319 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 300 mg po QID (8 times)<br />Midazolam: 5 mg iv single dose, concomitantly with the 5<sup>th</sup> cimetidine dose | | [Greenblatt 1986](#4-References) | | ||
| 1321 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 300 mg po QID (8 times)<br />Midazolam: 15 mg po single dose concomitantly with the 5<sup>th</sup> cimetidine dose | | [Greenblatt 1986](#4-References) | | ||
| 1322 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 800 mg po single dose <br />Midazolam: 7.5 mg po single dose concomitantly with cimetidine dose | | [Martinez 1999](#4-References) | | ||
| 1326 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 400 mg po single dose<br />Midazolam: 15 mg po single dose 2 hours after cimetidine dose | | [Salonen 1986](#4-References) | | ||
| 1346 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 200 mg po TID and 400 mg nocte on day before study and 200 mg on study day <br />Midazolam: 7.5 mg po single dose, 2.5 hours after last cimetidine dose | | [Elliott 1984](#4-references) | | ||
| 1324 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 400 mg po BID (3 times)<br />Midazolam: 15 mg po single dose, 1 hour after the last cimetidine dose | | [Fee 1987](#4-references) | | ||
| 1319 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 300 mg po QID (8 times)<br />Midazolam: 5 mg iv single dose, concomitantly with the 5<sup>th</sup> cimetidine dose | | [Greenblatt 1986](#4-references) | | ||
| 1321 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 300 mg po QID (8 times)<br />Midazolam: 15 mg po single dose concomitantly with the 5<sup>th</sup> cimetidine dose | | [Greenblatt 1986](#4-references) | | ||
| 1322 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 800 mg po single dose <br />Midazolam: 7.5 mg po single dose concomitantly with cimetidine dose | | [Martinez 1999](#4-references) | | ||
| 1326 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 400 mg po single dose<br />Midazolam: 15 mg po single dose 2 hours after cimetidine dose | | [Salonen 1986](#4-references) | | ||
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The release of the snapshot containing the respective simulations can be found here: | ||
https://github.com/Open-Systems-Pharmacology/Cimetidine-Triazolam-DDI/releases/tag/v1.1. | ||
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The cimetidine-triazolam interaction was evaluated using four clinical DDI studies quantifying the interaction following four different dosing regimens ([Pourbaix 1985](#4-References), [Abernethy 1983](#4-References), [Cox 1986](#4-References), [Friedman 1988](#4-References)). | ||
The cimetidine-triazolam interaction was evaluated using four clinical DDI studies quantifying the interaction following four different dosing regimens ([Pourbaix 1985](#4-references), [Abernethy 1983](#4-references), [Cox 1986](#4-references), [Friedman 1988](#4-references)). | ||
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| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study | | ||
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- | | ||
| 1342 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 200 mg po TID and 400 mg at bedtime over two weeks<br />Triazolam: 0.5 mg po OD in the second week concomitantly with bedtime dose | | [Pourbaix 1985](#4-References) | | ||
| 1334 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (4 times)<br />Triazolam: 0.5 mg po single dose concomitantly with cimetidine dose at 12 h | | [Abernethy 1983](#4-References) | | ||
| 1338 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (4 times)<br />Triazolam: 0.5 mg intraduodenal single dose, 13 hours after study start | | [Cox 1986](#4-References) | | ||
| 1336 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (8 times)<br />Triazolam: 0.5 mg po single dose concomitantly with the 5<sup>th</sup> cimetidine dose | | [Friedman 1988](#4-References) | | ||
| 1342 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 200 mg po TID and 400 mg at bedtime over two weeks<br />Triazolam: 0.5 mg po OD in the second week concomitantly with bedtime dose | | [Pourbaix 1985](#4-references) | | ||
| 1334 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (4 times)<br />Triazolam: 0.5 mg po single dose concomitantly with cimetidine dose at 12 h | | [Abernethy 1983](#4-references) | | ||
| 1338 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (4 times)<br />Triazolam: 0.5 mg intraduodenal single dose, 13 hours after study start | | [Cox 1986](#4-references) | | ||
| 1336 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (8 times)<br />Triazolam: 0.5 mg po single dose concomitantly with the 5<sup>th</sup> cimetidine dose | | [Friedman 1988](#4-references) | | ||
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The release of the snapshot containing the respective simulations can be found here: | ||
https://github.com/Open-Systems-Pharmacology/Cimetidine-Verapamil-DDI/releases/tag/v1.1. | ||
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The cimetidine-verapamil interaction was evaluated using a single clinical DDI study quantifying the interaction following two different dosing regimens ([Smith 1984](#4-References)). | ||
The cimetidine-verapamil interaction was evaluated using a single clinical DDI study quantifying the interaction following two different dosing regimens ([Smith 1984](#4-references)). | ||
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| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study | | ||
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- | | ||
| 1328 | CYP3A4 | Cimetidine / verapamil | Cimetidine: 300 mg po QID over eight days<br />Verapamil: 10 mg iv on day 8 concomitantly with the morning dose | | [Smith 1984](#4-References) | | ||
| 1330 | CYP3A4 | Cimetidine / verapamil | Cimetidine: 300 mg po QID over eight days<br />Verapamil: 120 mg po on day 8 concomitantly with the morning dose | | [Smith 1984](#4-References) | | ||
| 1328 | CYP3A4 | Cimetidine / verapamil | Cimetidine: 300 mg po QID over eight days<br />Verapamil: 10 mg iv on day 8 concomitantly with the morning dose | | [Smith 1984](#4-references) | | ||
| 1330 | CYP3A4 | Cimetidine / verapamil | Cimetidine: 300 mg po QID over eight days<br />Verapamil: 120 mg po on day 8 concomitantly with the morning dose | | [Smith 1984](#4-references) | | ||
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