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fix spellcheck and convert hyperlinks to lowcase (#15)
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* fix spellcheck and convert hyperlinks to lowcase

* fix spellcheck and convert hyperlinks to lowcase

* fix spellcheck and convert hyperlinks to lowcase

Co-authored-by: Yuri05 <Yuri05@github.com>
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Yuri05 and Yuri05 authored Oct 1, 2021
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27 changes: 24 additions & 3 deletions .github/workflows/wordlist.txt
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Expand Up @@ -1491,6 +1491,27 @@ Zhou
Zimmermann
Zoller
Zullino
fluvoxamine
triazolam
verapamil
fluvoxamine
triazolam
verapamil
Andersson
Bäckström
Bertilsson
Björkhem
Bredberg
Casjens
Chattopadhyay
Diczfalusy
glucuronidation
hydroxycholesterol
Kanacher
Kearney
Ligges
Massetto
Mosgau
Nii
Nylén
Ploeger
Rönquist
Schultze
vilaprisan
8 changes: 4 additions & 4 deletions .spellcheck.yml
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Expand Up @@ -9,10 +9,10 @@ matrix:
pipeline:
- pyspelling.filters.markdown:
- pyspelling.filters.html:
comments: false
ignores:
- code
- pre
comments: false
ignores:
- code
- pre
sources:
- '**/*.md'
default_encoding: utf-8
4 changes: 2 additions & 2 deletions Qualification/Input/Content/Cimetidine-Alfentanil-DDI.md
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The release of the snapshot containing the respective simulations can be found here:
https://github.com/Open-Systems-Pharmacology/Cimetidine-Alfentanil-DDI/releases/tag/v1.1.

The cimetidine-alfentanil interaction was evaluated using a single clinical DDI study quantifying the interaction following two different dosing regimens ([Kienlen 1993](#4-References)).
The cimetidine-alfentanil interaction was evaluated using a single clinical DDI study quantifying the interaction following two different dosing regimens ([Kienlen 1993](#4-references)).



| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study |
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- |
| 1344 | CYP3A4 | Cimetidine / alfentanil | Cimetidine: 1200 mg iv OD over 3 days<br />Alfentanil: 125 µg/kg iv on day 3 concomitantly with the cimetidine dose | No cross-over study! Parallel group design -> the two groups may not really be comparable given the low number of subjects and considering alfentanil PK variability | [Kienlen 1993](#4-References) |
| 1344 | CYP3A4 | Cimetidine / alfentanil | Cimetidine: 1200 mg iv OD over 3 days<br />Alfentanil: 125 µg/kg iv on day 3 concomitantly with the cimetidine dose | No cross-over study! Parallel group design -> the two groups may not really be comparable given the low number of subjects and considering alfentanil PK variability | [Kienlen 1993](#4-references) |

6 changes: 3 additions & 3 deletions Qualification/Input/Content/Cimetidine-Alprazolam-DDI.md
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The release of the snapshot containing the respective simulations can be found here:
https://github.com/Open-Systems-Pharmacology/Cimetidine-Alprazolam-DDI/releases/tag/v1.1.

The cimetidine-alprazolam interaction was evaluated using two clinical DDI studies quantifying the interaction following two different dosing regimens ([Pourbaix 1985](#4-References), [Abernethy 1983](#4-References)).
The cimetidine-alprazolam interaction was evaluated using two clinical DDI studies quantifying the interaction following two different dosing regimens ([Pourbaix 1985](#4-references), [Abernethy 1983](#4-references)).



| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study |
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- |
| 1340 | CYP3A4 | Cimetidine / alprazolam | Cimetidine: 200 mg po TID and 400 mg at bedtime over two weeks<br />Alprazolam: 0.5 mg po OD in the second week concomitantly with morning dose | | [Pourbaix 1985](#4-References) |
| 1332 | CYP3A4 | Cimetidine / alprazolam | Cimetidine: 300 mg po QID (4 times)<br />Alprazolam: 1 mg po single dose concomitantly with cimetidine dose at 12 h | | [Abernethy 1983](#4-References) |
| 1340 | CYP3A4 | Cimetidine / alprazolam | Cimetidine: 200 mg po TID and 400 mg at bedtime over two weeks<br />Alprazolam: 0.5 mg po OD in the second week concomitantly with morning dose | | [Pourbaix 1985](#4-references) |
| 1332 | CYP3A4 | Cimetidine / alprazolam | Cimetidine: 300 mg po QID (4 times)<br />Alprazolam: 1 mg po single dose concomitantly with cimetidine dose at 12 h | | [Abernethy 1983](#4-references) |

14 changes: 7 additions & 7 deletions Qualification/Input/Content/Cimetidine-Midazolam-DDI.md
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@@ -1,16 +1,16 @@
The release of the snapshot containing the respective simulations can be found here:
https://github.com/Open-Systems-Pharmacology/Cimetidine-Midazolam-DDI/releases/tag/v1.1.

The cimetidine-midazolam interaction was evaluated using five clinical DDI studies quantifying the interaction following six different dosing regimens ([Elliott 1984](#4-References), [Fee 1987](#4-References), [Greenblatt 1986](#4-References), [Martinez 1999](#4-References), [Salonen 1986](#4-References)).
The cimetidine-midazolam interaction was evaluated using five clinical DDI studies quantifying the interaction following six different dosing regimens ([Elliott 1984](#4-references), [Fee 1987](#4-references), [Greenblatt 1986](#4-references), [Martinez 1999](#4-references), [Salonen 1986](#4-references)).



| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study |
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- |
| 1346 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 200 mg po TID and 400 mg nocte on day before study and 200 mg on study day <br />Midazolam: 7.5 mg po single dose, 2.5 hours after last cimetidine dose | | [Elliott 1984](#4-References) |
| 1324 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 400 mg po BID (3 times)<br />Midazolam: 15 mg po single dose, 1 hour after the last cimetidine dose | | [Fee 1987](#4-References) |
| 1319 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 300 mg po QID (8 times)<br />Midazolam: 5 mg iv single dose, concomitantly with the 5<sup>th</sup> cimetidine dose | | [Greenblatt 1986](#4-References) |
| 1321 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 300 mg po QID (8 times)<br />Midazolam: 15 mg po single dose concomitantly with the 5<sup>th</sup> cimetidine dose | | [Greenblatt 1986](#4-References) |
| 1322 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 800 mg po single dose <br />Midazolam: 7.5 mg po single dose concomitantly with cimetidine dose | | [Martinez 1999](#4-References) |
| 1326 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 400 mg po single dose<br />Midazolam: 15 mg po single dose 2 hours after cimetidine dose | | [Salonen 1986](#4-References) |
| 1346 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 200 mg po TID and 400 mg nocte on day before study and 200 mg on study day <br />Midazolam: 7.5 mg po single dose, 2.5 hours after last cimetidine dose | | [Elliott 1984](#4-references) |
| 1324 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 400 mg po BID (3 times)<br />Midazolam: 15 mg po single dose, 1 hour after the last cimetidine dose | | [Fee 1987](#4-references) |
| 1319 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 300 mg po QID (8 times)<br />Midazolam: 5 mg iv single dose, concomitantly with the 5<sup>th</sup> cimetidine dose | | [Greenblatt 1986](#4-references) |
| 1321 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 300 mg po QID (8 times)<br />Midazolam: 15 mg po single dose concomitantly with the 5<sup>th</sup> cimetidine dose | | [Greenblatt 1986](#4-references) |
| 1322 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 800 mg po single dose <br />Midazolam: 7.5 mg po single dose concomitantly with cimetidine dose | | [Martinez 1999](#4-references) |
| 1326 | CYP3A4 | Cimetidine / midazolam | Cimetidine: 400 mg po single dose<br />Midazolam: 15 mg po single dose 2 hours after cimetidine dose | | [Salonen 1986](#4-references) |

10 changes: 5 additions & 5 deletions Qualification/Input/Content/Cimetidine-Triazolam-DDI.md
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@@ -1,14 +1,14 @@
The release of the snapshot containing the respective simulations can be found here:
https://github.com/Open-Systems-Pharmacology/Cimetidine-Triazolam-DDI/releases/tag/v1.1.

The cimetidine-triazolam interaction was evaluated using four clinical DDI studies quantifying the interaction following four different dosing regimens ([Pourbaix 1985](#4-References), [Abernethy 1983](#4-References), [Cox 1986](#4-References), [Friedman 1988](#4-References)).
The cimetidine-triazolam interaction was evaluated using four clinical DDI studies quantifying the interaction following four different dosing regimens ([Pourbaix 1985](#4-references), [Abernethy 1983](#4-references), [Cox 1986](#4-references), [Friedman 1988](#4-references)).



| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study |
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- |
| 1342 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 200 mg po TID and 400 mg at bedtime over two weeks<br />Triazolam: 0.5 mg po OD in the second week concomitantly with bedtime dose | | [Pourbaix 1985](#4-References) |
| 1334 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (4 times)<br />Triazolam: 0.5 mg po single dose concomitantly with cimetidine dose at 12 h | | [Abernethy 1983](#4-References) |
| 1338 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (4 times)<br />Triazolam: 0.5 mg intraduodenal single dose, 13 hours after study start | | [Cox 1986](#4-References) |
| 1336 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (8 times)<br />Triazolam: 0.5 mg po single dose concomitantly with the 5<sup>th</sup> cimetidine dose | | [Friedman 1988](#4-References) |
| 1342 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 200 mg po TID and 400 mg at bedtime over two weeks<br />Triazolam: 0.5 mg po OD in the second week concomitantly with bedtime dose | | [Pourbaix 1985](#4-references) |
| 1334 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (4 times)<br />Triazolam: 0.5 mg po single dose concomitantly with cimetidine dose at 12 h | | [Abernethy 1983](#4-references) |
| 1338 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (4 times)<br />Triazolam: 0.5 mg intraduodenal single dose, 13 hours after study start | | [Cox 1986](#4-references) |
| 1336 | CYP3A4 | Cimetidine / triazolam | Cimetidine: 300 mg po QID (8 times)<br />Triazolam: 0.5 mg po single dose concomitantly with the 5<sup>th</sup> cimetidine dose | | [Friedman 1988](#4-references) |

6 changes: 3 additions & 3 deletions Qualification/Input/Content/Cimetidine-Verapamil-DDI.md
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@@ -1,12 +1,12 @@
The release of the snapshot containing the respective simulations can be found here:
https://github.com/Open-Systems-Pharmacology/Cimetidine-Verapamil-DDI/releases/tag/v1.1.

The cimetidine-verapamil interaction was evaluated using a single clinical DDI study quantifying the interaction following two different dosing regimens ([Smith 1984](#4-References)).
The cimetidine-verapamil interaction was evaluated using a single clinical DDI study quantifying the interaction following two different dosing regimens ([Smith 1984](#4-references)).



| DataID | Enzyme | Perpetrator / victim | Study design | Comment | Clinical study |
| ------ | ------ | -------------------------- | ------------------------------------------------------------ | ------------------------------------------------------------ | ------------------------------------- |
| 1328 | CYP3A4 | Cimetidine / verapamil | Cimetidine: 300 mg po QID over eight days<br />Verapamil: 10 mg iv on day 8 concomitantly with the morning dose | | [Smith 1984](#4-References) |
| 1330 | CYP3A4 | Cimetidine / verapamil | Cimetidine: 300 mg po QID over eight days<br />Verapamil: 120 mg po on day 8 concomitantly with the morning dose | | [Smith 1984](#4-References) |
| 1328 | CYP3A4 | Cimetidine / verapamil | Cimetidine: 300 mg po QID over eight days<br />Verapamil: 10 mg iv on day 8 concomitantly with the morning dose | | [Smith 1984](#4-references) |
| 1330 | CYP3A4 | Cimetidine / verapamil | Cimetidine: 300 mg po QID over eight days<br />Verapamil: 120 mg po on day 8 concomitantly with the morning dose | | [Smith 1984](#4-references) |

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