Version 7.4.0

Downloads:

• Full setup

• Gene expression database (human)

Release Notes for the Open Systems Pharmacology Software Suite 7.4

Important note – read BEFORE installation

User Template Database migration from 7.3 (and below) to 7.4 and above

New features

64bit Support

All OSP Suite components (PK-Sim, MoBi, InstallationValidator, Toolboxes for Matlab and R) are now provided in the 64-bit version only. Development of the 32-bit version has stopped.

Documentation

The OSP Suite documentation was transferred into “wiki style” online version and is available via https://docs.open-systems-pharmacology.org/
Like in any “wiki”, changes can be proposed by everybody
(s. https://docs.open-systems-pharmacology.org/how-to-contribute for details)

New versions of Matlab and R

• OSP Suite Matlab Toolbox supports Matlab 2017b or later
• OSP Suite R Toolbox supports R 3.5 (64 bit)

Fixed issues and Improvements

PK-Sim and MoBi

• Add Volume unit µl
• Feature: Clear History
• Observed Data import: location of error is difficult to spot in long lists
• Manual editing of observed data: error after deleting value
• Content data not deleted in project
• Manual editing of Observed Data will not accept system decimal separator
• Simulation Chart Editor: Changing the Layout not working

PK-Sim

• Feature wish: Multiple metabolites arising from a single enzyme
• Allow user defined variability for more parameters
• Make Ontogeny factor, ontogeny factor GI visible and editable in a simulation
• Observed data import: "whole blood" cannot be selected as Compartment
• Allow import of observed data in amount (e.g. mg)
• Errors in storage of compound value origins in snapshot
• Update from Building Block: Problem with relative Expressions
• Wrong default distribution calculation method for template Midazolam
• Hill equation & free drug concentration
• Hill kinetic for pgp transports wrong
• Rifampicin template: all intestinal permeability values selected as default
• Make Hill kinetic more robust
• Trash bin in 'Grouping' window adds bin instead of deleting one
• Tablet delay factor is not visible
• When creating a new compound Value origin for pKa is filled
• Default alternative for intestinal/organ permeability corrupted after reimport from snapshot
• Value origin not set to Unknown if parameters are changed via Scale button
• Parameters changed via Scale button are not exported to Snapshot
• Errors in Digoxin template
• Exception error after Scale Individual to invalid body size
• Scale Individual: Change method default to "Use Source Value"
• Scale Individual: Manually entered reference concentration is reset
• Scale Individual: Select proper "Value Origin" field dependent on change method
• Value origins for pregnancy population not correct

MoBi

• Comma as decimal separator - inconsistent behavior

MoBi Toolbox for Matlab

• PKSimCreatePopulation: Ontogeny factor for enzymes not set

MoBi Toolbox for R

• New function request: compareSimulations
• Feature request: Simulate to steady-state
• New function request: getSolverWarnings
• existObserver fails if "Type" is not provided
• New function request: getEndSimulationResults
• MobiSettings should stop if the library path is not found
• New function: splitSimNameFromPath