diff --git a/cf_units/__init__.py b/cf_units/__init__.py
index 33366729..da56e291 100644
--- a/cf_units/__init__.py
+++ b/cf_units/__init__.py
@@ -32,7 +32,6 @@
 )
 
 from . import config
-from ._version import version as __version__  # noqa: F401
 from .util import _OrderedHashable
 
 __all__ = [
diff --git a/cf_units/_udunits2_parser/meson.build b/cf_units/_udunits2_parser/meson.build
new file mode 100644
index 00000000..40baeee6
--- /dev/null
+++ b/cf_units/_udunits2_parser/meson.build
@@ -0,0 +1,13 @@
+python_sources = [
+  '__init__.py',
+  'compile.py',
+  'graph.py',
+]
+
+py.install_sources(
+  python_sources,
+  pure: false,
+  subdir: 'cf_units/_udunits2_parser'
+)
+
+subdir('parser')
diff --git a/cf_units/_udunits2_parser/parser/meson.build b/cf_units/_udunits2_parser/parser/meson.build
new file mode 100644
index 00000000..84202f45
--- /dev/null
+++ b/cf_units/_udunits2_parser/parser/meson.build
@@ -0,0 +1,12 @@
+python_sources = [
+  '__init__.py',
+  'udunits2Lexer.py',
+  'udunits2Parser.py',
+  'udunits2ParserVisitor.py',
+]
+
+py.install_sources(
+  python_sources,
+  pure: false,
+  subdir: 'cf_units/_udunits2_parser/parser'
+)
diff --git a/cf_units/meson.build b/cf_units/meson.build
new file mode 100644
index 00000000..0cdac030
--- /dev/null
+++ b/cf_units/meson.build
@@ -0,0 +1,25 @@
+python_sources = [
+  '__init__.py',
+  'config.py',
+  'tex.py',
+  'util.py',
+]
+
+py.install_sources(
+  python_sources,
+  pure: false,
+  subdir: 'cf_units'
+)
+
+udunits2 = dependency('udunits')
+
+py.extension_module(
+    '_udunits2',
+    ['_udunits2.pyx'],
+    dependencies: [udunits2],
+    install: true,
+    subdir: 'cf_units'
+)
+
+subdir('tests')
+subdir('_udunits2_parser')
diff --git a/cf_units/tests/integration/meson.build b/cf_units/tests/integration/meson.build
new file mode 100644
index 00000000..41196399
--- /dev/null
+++ b/cf_units/tests/integration/meson.build
@@ -0,0 +1,16 @@
+python_sources = [
+  '__init__.py',
+  'test_date2num.py',
+  'test_num2date.py',
+  'test_num2pydate.py',
+  'test__Unit_date2num.py',
+  'test__Unit_num2date.py',
+]
+
+py.install_sources(
+  python_sources,
+  pure: false,
+  subdir: 'cf_units/tests/integration'
+)
+
+subdir('parse')
diff --git a/cf_units/tests/integration/parse/meson.build b/cf_units/tests/integration/parse/meson.build
new file mode 100644
index 00000000..bc4aa016
--- /dev/null
+++ b/cf_units/tests/integration/parse/meson.build
@@ -0,0 +1,10 @@
+python_sources = [
+  'test_graph.py',
+  'test_parse.py',
+]
+
+py.install_sources(
+  python_sources,
+  pure: false,
+  subdir: 'cf_units/tests/integration/parse'
+)
diff --git a/cf_units/tests/meson.build b/cf_units/tests/meson.build
new file mode 100644
index 00000000..79e96588
--- /dev/null
+++ b/cf_units/tests/meson.build
@@ -0,0 +1,15 @@
+python_sources = [
+  '__init__.py',
+  'test_coding_standards.py',
+  'test_tex.py',
+  'test_unit.py',
+]
+
+py.install_sources(
+  python_sources,
+  pure: false,
+  subdir: 'cf_units/tests'
+)
+
+subdir('integration')
+subdir('unit')
diff --git a/cf_units/tests/unit/meson.build b/cf_units/tests/unit/meson.build
new file mode 100644
index 00000000..b0d86cec
--- /dev/null
+++ b/cf_units/tests/unit/meson.build
@@ -0,0 +1,12 @@
+python_sources = [
+  '__init__.py',
+  'test__udunits2.py',
+]
+
+py.install_sources(
+  python_sources,
+  pure: false,
+  subdir: 'cf_units/tests/unit'
+)
+
+subdir('unit')
diff --git a/cf_units/tests/unit/unit/meson.build b/cf_units/tests/unit/unit/meson.build
new file mode 100644
index 00000000..ac07c789
--- /dev/null
+++ b/cf_units/tests/unit/unit/meson.build
@@ -0,0 +1,10 @@
+python_sources = [
+  'test_as_unit.py',
+  'test_Unit.py',
+]
+
+py.install_sources(
+  python_sources,
+  pure: false,
+  subdir: 'cf_units/tests/unit/unit'
+)
diff --git a/meson.build b/meson.build
new file mode 100644
index 00000000..ebc66067
--- /dev/null
+++ b/meson.build
@@ -0,0 +1,6 @@
+project('cf-units', 'cython', version: '1.3.0')
+
+py_mod = import('python')
+py = py_mod.find_installation(pure: true)
+
+subdir('cf_units')
diff --git a/pyproject.toml b/pyproject.toml
index 3fd0732b..21c3c3b6 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,14 +1,28 @@
-[build-system]
-# Defined by PEP 518
-requires = [
-  "setuptools>=45",
-  "setuptools_scm[toml]>=7.0",
-  "wheel",
-  "oldest-supported-numpy",
-  "Cython"
+[project]
+name = "cf-units"
+dynamic = ["version"]
+description = "Units of measure as required by the Climate and Forecast (CF) Metadata Conventions"
+requires-python = ">=3.10"
+readme = "README.md"
+dependencies = [
+     'python>=3.8',
+     'cftime>=1.6',
+     'Jinja2>=3',
+     'numpy>=1.18',
+     'antlr4-python3-runtime==4.11.1',
+]
+
+[project.optional-dependencies]
+build = [
+      'Cython>=3',
+      'meson-python>=0.15.0',
+      'pytest>=7',
+      'spin>=0.8',
 ]
-# Defined by PEP 517
-build-backend = "setuptools.build_meta"
+
+[build-system]
+requires = ['meson-python', 'cython']
+build-backend = 'mesonpy'
 
 [tool.coverage.run]
 branch = true
@@ -19,8 +33,6 @@ include = [
     "cf_units/*"
 ]
 omit = [
-    "setup.py",
-    "cf_units/_version.py",
     "cf_units/etc/*",
     "cf_units/tests/*",
     "cf_units/_udunits2_parser/parser/*",
@@ -35,12 +47,6 @@ exclude_lines = [
     "if __name__ == .__main__.:"
 ]
 
-[tool.pytest.ini_options]
-addopts = "-ra -v --doctest-modules"
-doctest_optionflags = "NORMALIZE_WHITESPACE ELLIPSIS NUMBER"
-minversion = "6.0"
-testpaths = "cf_units"
-
 [tool.setuptools_scm]
 write_to = "cf_units/_version.py"
 local_scheme = "dirty-tag"
@@ -73,3 +79,22 @@ line_length = 79
 profile = "black"
 skip_gitignore = "True"
 verbose = "False"
+
+[tool.spin]
+package = 'cf_units'
+
+[tool.spin.commands]
+Build = [
+    'spin.cmds.meson.build',
+    'spin.cmds.meson.test',
+    'spin.cmds.build.sdist',
+]
+Environments = [
+    'spin.cmds.meson.run',
+    'spin.cmds.meson.python',
+]
+
+[tool.pytest.ini_options]
+addopts = "-ra -v --doctest-modules"
+doctest_optionflags = "NORMALIZE_WHITESPACE ELLIPSIS NUMBER"
+minversion = "6.0"
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 2f50d221..00000000
--- a/setup.cfg
+++ /dev/null
@@ -1,98 +0,0 @@
-[metadata]
-author = SciTools Developers
-classifiers =
-    Development Status :: 5 - Production/Stable
-    Intended Audience :: Science/Research
-    License :: OSI Approved :: BSD License
-    Operating System :: OS Independent
-    Programming Language :: Python :: 3 :: Only
-    Programming Language :: Python :: 3.9
-    Programming Language :: Python :: 3.10
-    Programming Language :: Python :: 3.11
-    Topic :: Scientific/Engineering
-description = Units of measure as required by the Climate and Forecast (CF) metadata conventions
-download_url = https://github.com/SciTools/cf-units
-keywords =
-    units
-    cf
-    netcdf
-    science
-    oceanography
-    meteorology
-    climate
-license = BSD
-license_files = LICENSE
-long_description = file: README.md
-long_description_content_type = text/markdown
-name = cf-units
-project_urls =
-    Code = https://github.com/SciTools/cf-units
-    Discussions = https://github.com/SciTools/cf-units/discussions
-    Issues = https://github.com/SciTools/cf-units/issues
-url = https://github.com/SciTools/cf-units
-version = attr: cf_units.__version__
-
-[options]
-include_package_data = True
-install_requires =
-    antlr4-python3-runtime ==4.11.1  # To update this, see cf_units/_udunits2_parser/README.md
-    cftime >=1.2
-    jinja2
-    numpy
-    # udunits2 cannot be installed with pip, and it is expected to be
-    #  installed separately.
-packages = find_namespace:
-python_requires =
-    >=3.9
-zip_safe = False
-
-[options.extras_require]
-docs =
-    sphinx
-test =
-    codecov
-    cython
-    jinja2
-    pip
-    pytest
-    pytest-cov
-all =
-    pre-commit
-    %(docs)s
-    %(test)s
-
-[flake8]
-# References:
-#   https://flake8.readthedocs.io/en/latest/user/configuration.html
-#   https://flake8.readthedocs.io/en/latest/user/error-codes.html
-#   https://pycodestyle.readthedocs.io/en/latest/intro.html#error-codes
-
-select = C,E,F,W,B,B950
-ignore =
-    # E203: whitespace before ':'
-    E203,
-    # E226: missing whitespace around arithmetic operator
-    E226,
-    # E231: missing whitespace after ',', ';', or ':'
-    E231,
-    # E402: module level imports on one line
-    E402,
-    # E501: line too long
-    E501,
-    # E731: do not assign a lambda expression, use a def
-    E731,
-    # W503: line break before binary operator
-    W503,
-    # W504: line break after binary operator
-    W504
-exclude =
-    .eggs,
-    .git,
-    build,
-    cf_units/_version.py,
-    doc,
-    etc,
-    cf_units/_udunits2_parser/parser/*
-
-[aliases]
-test = pytest
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 34fb29e4..00000000
--- a/setup.py
+++ /dev/null
@@ -1,156 +0,0 @@
-import sys
-from distutils.sysconfig import get_config_var
-from os import environ
-from pathlib import Path
-from shutil import copy
-
-from setuptools import Command, Extension, setup
-
-# Default to using cython, but use the .c files if it doesn't exist
-try:
-    from Cython.Build import cythonize
-except ImportError:
-    cythonize = False
-
-COMPILER_DIRECTIVES = {}
-DEFINE_MACROS = None
-FLAG_COVERAGE = "--cython-coverage"  # custom flag enabling Cython line tracing
-BASEDIR = Path(__file__).resolve().parent
-PACKAGE = "cf_units"
-CFUNITS_DIR = BASEDIR / PACKAGE
-
-
-class CleanCython(Command):
-    description = "Purge artifacts built by Cython"
-    user_options = []
-
-    def initialize_options(self):
-        pass
-
-    def finalize_options(self):
-        pass
-
-    def run(self):
-        for path in CFUNITS_DIR.rglob("*"):
-            if path.suffix in (".pyc", ".pyo", ".c", ".so"):
-                msg = f"clean: removing file {path}"
-                print(msg)
-                path.unlink()
-
-
-def get_include_dirs():
-    include_dirs = []
-    include_dir = environ.get("UDUNITS2_INCDIR")
-    if include_dir is None:
-        include_dir = get_config_var("INCLUDEDIR")
-    if include_dir is not None:
-        include_dirs.append(include_dir)
-    return include_dirs
-
-
-def get_library_dirs():
-    library_dirs = []
-    library_dir = environ.get("UDUNITS2_LIBDIR")
-    if library_dir is None:
-        library_dir = get_config_var("LIBDIR")
-    if library_dir is not None:
-        library_dirs.append(library_dir)
-    return library_dirs
-
-
-def get_package_data():
-    package_data = {}
-    # Determine whether we're building a wheel.
-    if "bdist_wheel" in sys.argv:
-        # The protocol is that the UDUNITS2_XML_PATH environment variable
-        # identifies the root UDUNITS2 XML file and parent directory containing
-        # all the XML resource files that require to be bundled within this
-        # wheel. Note that, this should match the UDUNITS2 distribution for the
-        # UDUNITS2 library cf-units is linking against.
-        xml_env = "UDUNITS2_XML_PATH"
-        xml_database = environ.get(xml_env)
-        if xml_database is None:
-            emsg = f"Require to set {xml_env} for a cf-units wheel build."
-            raise ValueError(emsg)
-        xml_database = Path(xml_database)
-        if not xml_database.is_file():
-            emsg = (
-                f"Can't open {xml_env} file {xml_database} "
-                "during cf-units wheel build."
-            )
-            raise ValueError(emsg)
-        # We have a valid XML file, so copy the distro bundle into the
-        # cf_units/etc/share directory.
-        xml_dir = xml_database.expanduser().resolve().parent
-        share_base = Path("etc") / "share"
-        share_dir = CFUNITS_DIR / share_base
-        if not share_dir.is_dir():
-            share_dir.mkdir(parents=True)
-        else:
-            # Purge any existing XML share files.
-            [fname.unlink() for fname in share_dir.glob("*.xml")]
-        # Bundle the UDUNITS2 XML file/s for the wheel.
-        [copy(fname, share_dir) for fname in xml_dir.glob("*.xml")]
-        # Register our additional wheel content.
-        package_data = {PACKAGE: [str(share_base / "*.xml")]}
-    return package_data
-
-
-def numpy_build_ext(pars):
-    from setuptools.command.build_ext import build_ext as _build_ext
-
-    class build_ext(_build_ext):
-        def finalize_options(self):
-            # See https://github.com/SciTools/cf-units/issues/151
-            def _set_builtin(name, value):
-                if isinstance(__builtins__, dict):
-                    __builtins__[name] = value
-                else:
-                    setattr(__builtins__, name, value)
-
-            _build_ext.finalize_options(self)
-            _set_builtin("__NUMPY_SETUP__", False)
-            import numpy
-
-            self.include_dirs.append(numpy.get_include())
-
-    return build_ext(pars)
-
-
-if FLAG_COVERAGE in sys.argv or environ.get("CYTHON_COVERAGE", None):
-    COMPILER_DIRECTIVES = {"linetrace": True}
-    DEFINE_MACROS = [("CYTHON_TRACE", "1"), ("CYTHON_TRACE_NOGIL", "1")]
-    if FLAG_COVERAGE in sys.argv:
-        sys.argv.remove(FLAG_COVERAGE)
-    print('enable: "linetrace" Cython compiler directive')
-
-library_dirs = get_library_dirs()
-
-udunits_ext = Extension(
-    f"{PACKAGE}._udunits2",
-    [str(Path(f"{PACKAGE}") / f"_udunits2.{'pyx' if cythonize else 'c'}")],
-    include_dirs=get_include_dirs(),
-    library_dirs=library_dirs,
-    libraries=["udunits2"],
-    define_macros=DEFINE_MACROS,
-    runtime_library_dirs=None
-    if sys.platform.startswith("win")
-    else library_dirs,
-)
-
-if cythonize:
-    [udunits_ext] = cythonize(
-        udunits_ext,
-        compiler_directives=COMPILER_DIRECTIVES,
-        language_level="3str",
-    )
-
-cmdclass = {"clean_cython": CleanCython, "build_ext": numpy_build_ext}
-
-kwargs = dict(
-    cmdclass=cmdclass,
-    ext_modules=[udunits_ext],
-    package_data=get_package_data(),
-)
-
-setup(**kwargs)