fix: GPR curation for transport reactions (6)

SysBioChalmers · Dec 30, 2024 · 1f8445c · 1f8445c
1 parent 008b443
commit 1f8445c
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diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
@@ -149959,7 +149959,7 @@
           - MAM02900e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021488 or ENSG00000084453 or ENSG00000111700"
+      - gene_reaction_rule: "ENSG00000084453 or ENSG00000111700"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14579113"
       - subsystem:
@@ -150129,7 +150129,7 @@
           - MAM02901e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000021488 or ENSG00000084453 or ENSG00000111700"
+      - gene_reaction_rule: "ENSG00000084453 or ENSG00000111700"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14579113"
       - subsystem:
@@ -150461,7 +150461,6 @@
           - MAM02170e: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000169710"
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.3.1.85"
       - references: "PMID:1550832;PMID:8438778"
@@ -151475,7 +151474,7 @@
           - MAM01986e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000164363 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000149150 or ENSG00000164363"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151488,7 +151487,7 @@
           - MAM01307e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000155465"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151501,7 +151500,7 @@
           - MAM01975e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000123643 or ENSG00000149150 or ENSG00000155465"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151514,7 +151513,7 @@
           - MAM02896e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000149150 or ENSG00000155465"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151527,7 +151526,7 @@
           - MAM03089e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000112394 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000112394 or ENSG00000123643 or ENSG00000149150 or ENSG00000155465 or ENSG00000167703"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151540,7 +151539,7 @@
           - MAM02724e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000112394 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000112394 or ENSG00000149150 or ENSG00000155465 or ENSG00000167703"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151553,7 +151552,7 @@
           - MAM01628e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000130876 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151566,7 +151565,7 @@
           - MAM02360e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000123643 or ENSG00000149150 or ENSG00000155465 or ENSG00000167703"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151579,7 +151578,7 @@
           - MAM02770e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000003989 or ENSG00000092068 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "ENSG00000092068 or ENSG00000123643 or ENSG00000149150 or ENSG00000155465"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151592,7 +151591,7 @@
           - MAM01369e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000123643 or ENSG00000149150 or ENSG00000155465"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151605,7 +151604,7 @@
           - MAM03135e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000123643 or ENSG00000149150 or ENSG00000155465 or ENSG00000167703"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -151618,7 +151617,7 @@
           - MAM02993e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"
+      - gene_reaction_rule: "(ENSG00000092068 and ENSG00000168003) or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -155080,7 +155079,7 @@
           - MAM02724e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -155284,7 +155283,7 @@
           - MAM02896e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000105281"
+      - gene_reaction_rule: "ENSG00000105281"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -155879,7 +155878,7 @@
           - MAM03089e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064 or ENSG00000103257"
+      - gene_reaction_rule: "ENSG00000103257"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -156015,7 +156014,6 @@
           - MAM02724e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -157647,7 +157645,6 @@
           - MAM03135e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -158225,7 +158222,6 @@
           - MAM02770e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000103064"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14770309;PMID:14770310"
       - subsystem:
@@ -161329,7 +161325,7 @@
           - MAM02403e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"
+      - gene_reaction_rule: "ENSG00000100156 or ENSG00000118596 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12739169"
       - subsystem:
@@ -161569,7 +161565,7 @@
           - MAM02833e: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"
+      - gene_reaction_rule: "ENSG00000100156 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12739169"
       - subsystem:
@@ -166585,7 +166581,6 @@
           - MAM01517g: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000174669"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -170177,7 +170172,7 @@
           - MAM02519e: -2
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000196517 or ENSG00000268104"
+      - gene_reaction_rule: "ENSG00000268104"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -173644,7 +173639,6 @@
           - MAM01642m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000125454"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:14598172"
       - subsystem:
@@ -173734,7 +173728,6 @@
           - MAM02914m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000160190"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12811562"
       - subsystem:
@@ -174045,7 +174038,6 @@
           - MAM01680m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000125454"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -174283,7 +174275,6 @@
           - MAM01756m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000125454"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -174521,7 +174512,6 @@
           - MAM01747m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000125454"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -177383,7 +177373,6 @@
           - MAM02471l: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000123643"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:12930836;PMID:16288981;PMID:911815;PMID:10049700;PMID:10574970;PMID:11389679;PMID:11557028;PMID:11564694;PMID:12824232;PMID:14574404"
       - subsystem:
@@ -177498,7 +177487,6 @@
           - MAM02993l: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000123643"
       - rxnFrom: "HMRdatabase"
       - references: "PMID:911815"
       - subsystem:
@@ -179568,7 +179556,7 @@
           - MAM02200g: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000065923 or ENSG00000197818"
+      - gene_reaction_rule: "ENSG00000065923"
       - rxnFrom: "HMRdatabase"
       - subsystem:
           - "Transport reactions"
@@ -210686,7 +210674,6 @@
           - MAM02770e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000115902"
       - rxnFrom: "Recon3D"
       - references: "PMID:14502423;PMID:11824937"
       - subsystem:
@@ -212934,7 +212921,7 @@
           - MAM02946e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000137204 or ENSG00000149452 or ENSG00000168065"
+      - gene_reaction_rule: "ENSG00000137204 or ENSG00000149452"
       - rxnFrom: "Recon3D"
       - subsystem:
           - "Transport reactions"
@@ -215404,7 +215391,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000073734 or ENSG00000108846 or ENSG00000121270"
+      - gene_reaction_rule: "ENSG00000073734 or ENSG00000108846"
       - rxnFrom: "Recon3D"
       - subsystem:
           - "Transport reactions"
@@ -265968,9 +265955,6 @@
     - !!omap
       - id: "ENSG00000160179"
       - name: "ABCG1"
-    - !!omap
-      - id: "ENSG00000160190"
-      - name: "SLC37A1"
     - !!omap
       - id: "ENSG00000160191"
       - name: "PDE9A"

diff --git a/model/genes.tsv b/model/genes.tsv
@@ -1816,7 +1816,6 @@
 "ENSG00000160014"	"ENST00000391918;ENST00000597743;ENST00000477244;ENST00000598871;ENST00000291295;ENST00000595072;ENST00000602169;ENST00000594523;ENST00000597868;ENST00000599839;ENST00000596362;ENST00000482455;ENST00000486500"	"ENSP00000375785;ENSP00000470308;ENSP00000470502;ENSP00000291295;ENSP00000499372;ENSP00000468877;ENSP00000471225;ENSP00000472141"	"P0DP25"	"CALM3"	"808"	"calmodulin 3"	"PHKD"	"Cytosol"	"SwissProt"
 "ENSG00000160087"	"ENST00000450390;ENST00000349431;ENST00000400929;ENST00000464036;ENST00000360466;ENST00000400930;ENST00000467339;ENST00000473215;ENST00000435198;ENST00000509720;ENST00000491779;ENST00000466752;ENST00000503294;ENST00000477894;ENST00000471154;ENST00000422076;ENST00000502382;ENST00000461142;ENST00000488418;ENST00000347370"	"ENSP00000407565;ENSP00000305826;ENSP00000383718;ENSP00000423880;ENSP00000353653;ENSP00000383719;ENSP00000427024;ENSP00000393301;ENSP00000425419;ENSP00000422103;ENSP00000425543;ENSP00000423480;ENSP00000401898;ENSP00000424342;ENSP00000427244;ENSP00000344857"	"Q8N2K1"	"UBE2J2"	"118424"	"ubiquitin conjugating enzyme E2 J2"	"NCUBE2;Ubc6p"	"Endoplasmic reticulum"	"SwissProt"
 "ENSG00000160179"	"ENST00000398457;ENST00000462050;ENST00000347800;ENST00000450121;ENST00000361802;ENST00000398449;ENST00000343687;ENST00000398437;ENST00000472587;ENST00000467818;ENST00000496783"	"ENSP00000381475;ENSP00000291524;ENSP00000414541;ENSP00000354995;ENSP00000381467;ENSP00000339744;ENSP00000381464"	"P45844"	"ABCG1"	"9619"	"ATP binding cassette subfamily G member 1"	"ABC8"	"Endoplasmic reticulum;Golgi apparatus"	"SwissProt;CellAtlas"
-"ENSG00000160190"	"ENST00000454800;ENST00000419522;ENST00000398341;ENST00000484887;ENST00000352133;ENST00000471277;ENST00000398343;ENST00000487951;ENST00000496416"	"ENSP00000410129;ENSP00000381383;ENSP00000344648;ENSP00000381385"	"P57057"	"SLC37A1"	"54020"	"solute carrier family 37 member 1"	""	"Cell membrane;Endoplasmic reticulum"	"DeepLoc2"
 "ENSG00000160191"	"ENST00000291539;ENST00000460905;ENST00000472401;ENST00000335512;ENST00000470987;ENST00000490803;ENST00000486902;ENST00000328862;ENST00000335440;ENST00000380328;ENST00000398225;ENST00000398227;ENST00000398229;ENST00000398232;ENST00000398234;ENST00000398236;ENST00000460989;ENST00000462571;ENST00000467403;ENST00000468805;ENST00000495521;ENST00000497805;ENST00000349112;ENST00000398224;ENST00000467162;ENST00000495343;ENST00000489319;ENST00000466472"	"ENSP00000291539;ENSP00000335242;ENSP00000328699;ENSP00000335365;ENSP00000369685;ENSP00000381281;ENSP00000381283;ENSP00000381285;ENSP00000381287;ENSP00000381289;ENSP00000381291;ENSP00000344730;ENSP00000381280"	"O76083"	"PDE9A"	"5152"	"phosphodiesterase 9A"	""	"Endoplasmic reticulum;Golgi apparatus;Nucleus;Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000160194"	"ENST00000460259;ENST00000340344;ENST00000354250;ENST00000460740"	"ENSP00000342895;ENSP00000346196"	"P56181"	"NDUFV3"	"4731"	"NADH:ubiquinone oxidoreductase subunit V3"	"CI-10k"	"Inner mitochondria"	"SwissProt;CellAtlas"
 "ENSG00000160200"	"ENST00000461686;ENST00000398158;ENST00000398165;ENST00000359624;ENST00000352178;ENST00000451248;ENST00000462349;ENST00000491776;ENST00000458223;ENST00000430013;ENST00000496485;ENST00000486098;ENST00000441030;ENST00000470912;ENST00000465732;ENST00000488526;ENST00000478709"	"ENSP00000381225;ENSP00000381231;ENSP00000352643;ENSP00000344460;ENSP00000402823;ENSP00000408014;ENSP00000405929;ENSP00000388235"	"P35520"	"CBS"	"875"	"cystathionine beta-synthase"	"HIP4"	"Nucleus;Cytosol"	"SwissProt;CellAtlas"