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Fix: GPR curation for pyrimidine metabolism #932

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merged 3 commits into from
Dec 17, 2024

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JHL-452b
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@JHL-452b JHL-452b commented Dec 5, 2024

Main improvements in this PR:

As proposed in #857

  • Remove ENSG00000143156 from MAR04006;
  • Remove ENSG00000143156 from MAR04028;
  • Remove ENSG00000125458, ENSG00000205309, ENSG00000146587 from MAR04177;
  • Remove ENSG00000205309, ENSG00000125458 from MAR04179;
  • Remove ENSG00000141560, ENSG00000172456, ENSG00000167363, ENSG00000162408, ENSG00000116199 from MAR04182;
  • Remove ENSG00000141698, ENSG00000116981, ENSG00000076685, ENSG00000146587 from MAR04484;
  • Remove ENSG00000205309 from MAR04510;
  • Remove ENSG00000125877 from MAR04643;
  • Remove ENSG00000130717 from MAR04676;
  • Remove ENSG00000092964 from MAR04346;
  • Remove ENSG00000167900 from MAR06623;
  • Remove ENSG00000143156 from MAR04030;
  • Remove ENSG00000154269 from MAR04127;
  • Remove ENSG00000125877 from MAR04211;
  • Remove ENSG00000092964 from the model as they are not connected to any reactions after this curation.

I hereby confirm that I have:

  • Tested my code on my own computer for running the model
  • Selected develop as a target branch
  • [] Any removed reactions and metabolites have been moved to the corresponding deprecated identifier lists

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github-actions bot commented Dec 5, 2024

This PR has been automatically tested with GH Actions. Here is the output of the MACAW test:

Starting dead-end test...
- Found 1514 dead-end metabolites.
- Found 1319 reactions incapable of sustaining steady-state fluxes in either direction due to these dead-ends.
- Found 1977 reversible reactions that can only carry steady-state fluxes in a single direction due to dead-ends.
Starting duplicate test...
- Skipping redox duplicates because no redox_pairs and/or proton_ids were provided.
- Found 447 reactions that were some type of duplicate:
- 0 were completely identical to at least one other reaction.
- 13 involve the same metabolites but go in the opposite direction or have the opposite reversibility as at least one other reaction.
- 447 involve the same metabolites but with different coefficients as at least one other reaction.

This and a more detailed output from MACAW are also committed to data/macawResults/.

Note: In the case of multiple test runs, this post will be edited.

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@feiranl feiranl left a comment

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LGTM!

…abolism

# Conflicts:
#	data/testResults/README.md
@edkerk edkerk merged commit 8dda4f7 into develop Dec 17, 2024
0 of 6 checks passed
@edkerk edkerk deleted the Fix-Pyrimidine_metabolism branch December 17, 2024 01:01
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3 participants