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Human 1.18.0

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@haowang-bioinfo haowang-bioinfo released this 08 Dec 14:29
· 153 commits to main since this release
  • Fixes (PR #740)
    • remove ACAD10 from the GPRs of MAR03212 and MAR03163, as well as from Human-GEM altogether, as explained in #739
  • Fixes (PR #725)
    • remove duplicate 2-oxoadipate dehydrogenase reaction MAR04239, modify GPRs of MAR04599, MAR04209, and MAR06413, remove ENSG00000197444 (OGDHL) gene, as well as incoporate other miscellaneous curations, based on investigation results presented in #719
  • Fixes (PR #724)
    • replace inaccurate GPR and reference for MAR04665 with ENSG00000182199 (SHMT2) and "PMID:11087421", as discussed in #720
  • Fixes (PR #723)
    • revise mitochondrial Glutathione transport reactions as discussed in #722, by modifying MAR08771, and removing MAR04940 and MAR06391
  • Style (PR #721)
    • add Christoff1993 as a contributor
  • Fixes (PR #717)
    • resolve duplicate chemical speices hexanoate/hexanoic acid by systematically replacing hexanoate (MAM03684c) with hexanoic acid (MAM02120c), as reported by #716
  • Fixes (PR #715)
    • curate GPRs and reaction names of 62 cytosolic short- and medium-chain fatty acid hydrolysis reactions, as proposed in #689
    • add 4 new hydrolysis reactions
    • add 2 new genes THEM4 (ENSG00000159445) and THEM5 (ENSG00000196407)
  • Fixes (PR #714)
    • refine GPRs involving LIPT1 (ENSG00000144182) gene, as explained in #683
      • remove LIPT1 (ENSG00000144182) from the GPRs of MAR01088 and MAR01091
      • remove MAR06398, MAR06399, and MAM02398c (lipoyl-AMP), MAR06408, and MAM01701c
      • replace MAM02393m with MAM00209c in MAR08433, MAM01701m with MAM00208c in MAR08434
      • remove MAM02039c and MAM02039e from MAR11346
      • remove MAM02039i and MAM02039m from MAR11361
      • make MAR11361 reversible
  • Fixes (PR #713)
    • split formuate dihydroorotate dehydrogenase reaction MAR04575 into two steps by adding new met MAM20019c (FMNH2) and new rxn MAR20167, as advised in #609
  • Fixes (PR #712)
    • update and maintain consistency in the met IDs for FMN and FMNH2 and update their annotations, according to #711
  • Fixes (PR #710)
    • remove duplicate glycerol-3-phosphate dehydrogenase rxns MAR00478 and MAR00482 and update annotations, as proposed in #599
  • Fixes (PR #709)
    • reorganize nucleotide transport reactions [c]<->[m] by adding genes, reactions, updating GPRs, and removing reactions lack of proper transporters, as listed in #694
  • Fixes (PR #708)
    • revises tryptophan metabolism reactions and GPRs, as outlined in #545
      • remove ENSG00000159423 (ALDH4A1) from MAR00051
      • remove MAR08564+MAR08565 that are duplicate to MAR04222
      • merge annotations for MAR08564+MAR08565 to that of MAR04222
      • remove derived orhpan met MAM00926c (4-(2-aminophenyl)-2,4-dioxobutanoate)
  • Fixes (PR #707)
    • remove MAR06400 and MAR06401 for being duplicate to MAR06403 and MAR06402, respectively, as illustrated in #682
    • update reaction annotation and remove derived orphan met MAM02397c (lipoyl-[ACP])
  • Fixes (PR #706)
    • remove lipoic acid transport reactions MAR01483 and MAR06406 that are less accurate duplicates of MAR09608, as notified in #679
    • merge annotations of MAR01483 and MAR06406 into MAR09608, update Rhea ids and references
  • Fixes (PR #703)
    • merge "Heme biosynthesis" subsystem into "Porphyrin metabolism", to address issues raised in #356 and #681
  • Fixes (PR #702)
    • remove MAR03940 for being redundant with MAR08539+MAR08538, as discovered in #632
  • Fixes (PR #701)
    • extensively revise cofactor transport reactions between cytosol <-> peroxisome, as proposed in #640
  • Fixes (PR #697)
    • comment-out tasks (37, 38, and 181) with NA[c] metabolite in Cellfile metabolic tasks, as discussed in #696
  • Fixes (PR #696)
    • update metabolite name from GAP[c] to D-glyceraldehyde 3-phosphate[c] in Cellfile metabolic tasks, by following the change in #500
  • Fixes (PR #582)
    • enable GitHub action check for detecting duplicate reactions by enabling sanityCheck to report reactions with identical metabolite IDs
    • remove MAR20012 and MAR20089 that are duplicate to MAR06646 and MAR04545, respectively
  • Fixes (PR #512)
    • change the dependency of Yamllint workflow to the repo hosted by metabolicatlas