Dynamic remodeling of cell type-specific epigenetic landscape driving failed repair in acute kidney injury

Yoshiharu Muto, Eryn E. Dixon, Yasuhiro Yoshimura, Nicolas Ledru, Haojia Wu and Benjamin D. Humphreys

Welcome to our GitHub repository!
Here you will find preprocessing scripts for our project where we analyzed snATACseq data for the mouse kidneys with ischemia-reperfusion injury along time course. Please contact the corresponding author, Dr. Benjamin Humphreys, with questions or comments.

Thanks,
Benjamin D. Humphreys, Yoshiharu Muto

This work is on the following manuscript

Epigenetic reprogramming driving successful and failed repair in acute kidney injury
Yoshiharu Muto, Eryn E. Dixon, Yasuhiro Yoshimura, Haojia Wu, Nicolas Ledru, Yuhei Kirita and Benjamin D. Humphreys
doi: https://doi.org/10.1101/2024.01.20.576421

Visit the Humphrey's lab website:
www.humphreyslab.com

Check out our interactive datasets with Kidney Interactive mulTiomics (KIT):
http://humphreyslab.com/SingleCell/

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• snRNA-seq data for mouse IRI kidneys (whole dataset / PTC subclustering / Immune cell subclucstering) were previously published
• Proc Natl Acad Sci U S A 2020 Jul 7;117(27):15874-15883. doi: 10.1073/pnas.2005477117 https://www.pnas.org/doi/abs/10.1073/pnas.2005477117