diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 002d3919..556f2dc1 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -52,13 +52,14 @@ jobs:
       with:
         python-version: ${{ matrix.python-version }}
         allow-prereleases: true
-        cache: pip
-        cache-dependency-path: 'requirements/*.txt'
+
+    - name: Install uv
+      uses: astral-sh/setup-uv@v1
+      with:
+        enable-cache: true
 
     - name: Install dependencies
-      run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip install --upgrade 'tox>=4.0.0rc3'
+      run: uv pip install --system tox tox-uv
 
     - name: Install percona-toolkit
       run: |
@@ -94,8 +95,11 @@ jobs:
         with:
           python-version: '3.12'
 
+      - name: Install uv
+        uses: astral-sh/setup-uv@v1
+
       - name: Install dependencies
-        run: python -m pip install --upgrade coverage[toml]
+        run: uv pip install --system coverage[toml]
 
       - name: Download data
         uses: actions/download-artifact@v4