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---
title: Andrew John Hill
layout: front_page
---
<div class="container">
<div class="section">
<div class="about-me">
<div class="about-me-content">
<img src="/images/headshot.png" alt="Andrew John Hill" class="headshot">
<div class="about-me-text">
<p class="leadText">
I am a passionate technologist and scientist with training in bioengineering, computational biology, and molecular biology. Through my roles in academia and the biotech industry, I've led highly interdisciplinary projects within fields such as high-throughput single-cell assay development, epigenetic editing in the context of gene and cell therapy, and antibody discovery and engineering.
</p>
<p class="leadText">
Please reach out if you'd like to get in touch!
</p>
{% include socialMediaLinks.html %}
</div>
</div>
</div>
</div>
<div class="section">
<div class="cv-button-container">
<a href="/documents/Hill_A CV.pdf"><span class="call-to-action-button">Download CV</span></a>
</div>
<div class="timeline">
<div class="timeline-container">
<ul class="timeline-list">
<li class="timeline-item">
<div class="timeline-info">
<span class="timeline-date">2023</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/infinimmune.jpg" alt="Infinimmune" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>Scientist (Computational Biology)</h3>
<p class="timeline-workplace">Infinimmune</p>
<p class="timeline-description">Part of a small team developing a novel antibody discovery and engineering platform.</p>
</div>
</div>
</li>
<li class="timeline-item">
<div class="timeline-info">
<span class="timeline-date">2022</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/tunetx.jpeg" alt="Tune Therapeutics" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>Senior Computational Biologist</h3>
<p class="timeline-workplace">Tune Therapeutics</p>
<p class="timeline-description">Co-led the implementation of high-throughput screening approaches for target discovery and engineering improved epigenetic editing systems.</p>
</div>
</div>
</li>
<li class="timeline-item">
<div class="timeline-info">
<span class="timeline-date">2019</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/10x_genomics.png" alt="10x Genomics" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>Senior Computational Biologist</h3>
<p class="timeline-workplace">10x Genomics</p>
<p class="timeline-description">Core contributor to Gene Expression Flex (formerly Fixed RNA Profiling), Targeted Gene Expression, and Chromium X products. Probe design work for all probe-based assays including Gene Expression Flex, Visium for FFPE, Visium HD, and Xenium In-Situ.</p>
</div>
</div>
</li>
<li class="timeline-item education">
<div class="timeline-info">
<span class="timeline-date">2014-2019</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/uw.png" alt="University of Washington" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>Ph.D. in Genome Sciences</h3>
<p class="timeline-workplace">University of Washington</p>
</div>
</div>
</li>
<li class="timeline-item">
<div class="timeline-info">
<span class="timeline-date">2016</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/10x_genomics.png" alt="10x Genomics" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>Computational Biology Intern</h3>
<p class="timeline-workplace">10x Genomics</p>
<p class="timeline-description">Contributed to software and assay development for initial Immune Profiling product. Extensive development of internal interactive visualizations that inspired Loupe for VDJ.</p>
</div>
</div>
</li>
<li class="timeline-item education">
<div class="timeline-info">
<span class="timeline-date">2014</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/uw.png" alt="University of Washington" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>Graduate Student and NSF GRFP Fellow</h3>
<p class="timeline-workplace">Shendure Lab, University of Washington</p>
<p class="timeline-description">Research focused on single-cell multiomics assays and high dimensional readouts for genetic screens.</p>
</div>
</div>
</li>
<li class="timeline-item">
<div class="timeline-info">
<span class="timeline-date">2013</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/mgh.jpg" alt="Massachusetts General Hospital" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>Research Assistant</h3>
<p class="timeline-workplace">MacArthur Lab, Massachusetts General Hospital</p>
<p class="timeline-description">Introductory projects in genomics and contributions to the ExAC project.</p>
</div>
</div>
</li>
<li class="timeline-item education">
<div class="timeline-info">
<span class="timeline-date">2008 - 2012</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/uw.png" alt="University of Washington" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>B.S. in Bioengineering (UW Honors Department)</h3>
<p class="timeline-workplace">University of Washington</p>
</div>
</div>
</li>
<li class="timeline-item education">
<div class="timeline-info">
<span class="timeline-date">2010</span>
</div>
<div class="timeline-marker"></div>
<div class="timeline-content">
<img src="/images/company_thumbnails/uw.png" alt="University of Washington" class="timeline-company-logo">
<div class="timeline-text-content">
<h3>Undergraduate Researcher</h3>
<p class="timeline-workplace">Biorobotics Lab, University of Washington</p>
<p class="timeline-description">Built a robotic device to enable charecterization of soft tissue mechanics.</p>
</div>
</div>
</li>
</ul>
</div>
</div>
</div>
<div class="section projects">
<h1>Publications</h1>
<h2>10x Genomics</h2>
<div class="project-grid">
<div class="project-tile">
<a href="/documents/publications/10x_ffpe_biorxiv.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/10x_ffpe_biorxiv.png" alt="10x Dev. Teams; bioRxiv 2022">
</div>
<div class="project-info">
<h3>High resolution mapping of the breast cancer tumor microenvironment</h3>
<p><strong>Authors:</strong> Janesick, <i>et al.</i></p>
<p><strong>Authorship:</strong> 10x Dev. Teams</p>
<p><strong>Published:</strong> bioRxiv, 2022</p>
</div>
</a>
</div>
</div>
<h2>Shendure Lab</h2>
<div class="project-grid">
<div class="project-tile">
<a href="/documents/publications/fetal_atac_atlas_science.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/fetal_atac_atlas_science.png" alt="1st Author; Science 2022">
</div>
<div class="project-info">
<h3>A human cell atlas of fetal chromatin accessibility</h3>
<p><strong>Authors:</strong> Domcke, Hill, Daza, <i>et al.</i></p>
<p><strong>Authorship:</strong> 1st Author</p>
<p><strong>Published:</strong> Science, 2022</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/emt_screen.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/emt_screen.png" alt="2nd Author; Nature Genetics 2019">
</div>
<div class="project-info">
<h3>A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition</h3>
<p><strong>Authors:</strong> McFaline-Figueroa, <i>et al.</i></p>
<p><strong>Authorship:</strong> 2nd Author</p>
<p><strong>Published:</strong> Nature Genetics, 2019</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/nature.mouse_development_atlas.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/nature.mouse_development_atlas.png" alt="Middle Author; Nature 2019">
</div>
<div class="project-info">
<h3>The single-cell transcriptional landscape of mammalian organogenesis</h3>
<p><strong>Authors:</strong> Cao and Spielmann, <i>et al.</i></p>
<p><strong>Authorship:</strong> Middle Author</p>
<p><strong>Published:</strong> Nature, 2019</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/enhancer_screen_cell.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/enhancer_screen_cell.png" alt="2nd Author; Cell 2019">
</div>
<div class="project-info">
<h3>A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens</h3>
<p><strong>Authors:</strong> Gasperini, <i>et al.</i></p>
<p><strong>Authorship:</strong> 2nd Author</p>
<p><strong>Published:</strong> Cell, 2019 (bioRxiv 2018)</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/science.aau0730.full.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/science.aau0730.full.png" alt="Middle Author; Science 2018">
</div>
<div class="project-info">
<h3>Joint profiling of chromatin accessibility and gene expression in thousands of single cells</h3>
<p><strong>Authors:</strong> Cao, <i>et al.</i></p>
<p><strong>Authorship:</strong> Middle Author</p>
<p><strong>Published:</strong> Science, 2018</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/cell.mouse_atac.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/cell.mouse_atac.png" alt="1st Author; Cell 2018">
</div>
<div class="project-info">
<h3>A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility</h3>
<p><strong>Authors:</strong> Cusanovich and Hill, <i>et al.</i></p>
<p><strong>Authorship:</strong> 1st Author</p>
<p><strong>Published:</strong> Cell, 2018</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/nmeth.4604.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/nmeth.4604.png" alt="1st Author; Nature Methods 2018">
</div>
<div class="project-info">
<h3>On the design of CRISPR-based single-cell molecular screens</h3>
<p><strong>Authors:</strong> Hill and McFaline-Figueroa, <i>et al.</i></p>
<p><strong>Authorship:</strong> 1st Author</p>
<p><strong>Published:</strong> Nature Methods, 2018</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/nmeth.census.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/nmeth.census.png" alt="2nd Author; Nature Methods 2017">
</div>
<div class="project-info">
<h3>Single-cell mRNA quantification and differential analysis with Census</h3>
<p><strong>Authors:</strong> Qiu, <i>et al.</i></p>
<p><strong>Authorship:</strong> 2nd Author</p>
<p><strong>Published:</strong> Nature Methods, 2017</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/cell.cfdna.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/cell.cfdna.png" alt="3rd Author; Cell 2016">
</div>
<div class="project-info">
<h3>Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin</h3>
<p><strong>Authors:</strong> Snyder and Kircher, <i>et al.</i></p>
<p><strong>Authorship:</strong> 3rd Author</p>
<p><strong>Published:</strong> Cell, 2016</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/genome_biology.bipartite_x.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/genome_biology.bipartite_x.png" alt="Middle Author; Genome Biology 2015">
</div>
<div class="project-info">
<h3>Bipartite structure of the inactive mouse X-chromosome</h3>
<p><strong>Authors:</strong> Deng and Ma, <i>et al.</i></p>
<p><strong>Authorship:</strong> Middle Author</p>
<p><strong>Published:</strong> Genome Biology, 2015</p>
</div>
</a>
</div>
</div>
<h2>MacArthur Lab</h2>
<div class="project-grid">
<div class="project-tile">
<a href="/documents/publications/mnvs_biorxiv.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/mnvs_biorxiv.png" alt="Middle Author; bioRxiv 2019">
</div>
<div class="project-info">
<h3>Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes</h3>
<p><strong>Authors:</strong> Wang, <i>et al.</i></p>
<p><strong>Authorship:</strong> Middle Author</p>
<p><strong>Published:</strong> bioRxiv, 2019</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/documents/publications/nature.exac.pdf">
<div class="project-thumbnail">
<img src="/images/publications_thumbnails/nature.exac.png" alt="Middle Author; Nature 2016">
</div>
<div class="project-info">
<h3>Analysis of protein-coding genetic variation in 60,706 humans</h3>
<p><strong>Authors:</strong> Lek, <i>et al.</i></p>
<p><strong>Authorship:</strong> Middle Author</p>
<p><strong>Published:</strong> Nature, 2016</p>
</div>
</a>
</div>
</div>
</div>
<div class="section projects">
<h1>Unpublished Projects</h1>
<h2>UW Genome Sciences</h2>
<div class="project-grid">
<div class="project-tile">
<a href="/publications/uw-genome-sciences/#epicviz">
<div class="project-thumbnail">
<img src="/images/projects/epicviz.png" alt="EPICViz">
</div>
<div class="project-info">
<h3>EPICViz</h3>
<p><strong>Type:</strong> Web Visualization</p>
<p><strong>Description:</strong> D3 web visualization of single-cell position and gene expression in C. Elegans.</p>
</div>
</a>
</div>
</div>
</div>
<div class="section projects">
<h2>UW Biorobotics Lab</h2>
<div class="project-grid">
<div class="project-tile">
<a href="/publications/uw-brl/#capstone">
<div class="project-thumbnail">
<img src="/images/projects/capstone.png" alt="Online Modeling of Soft-Tissue">
</div>
<div class="project-info">
<h3>Online Modeling of Soft-Tissue</h3>
<p><strong>Type:</strong> Capstone Project</p>
<p><strong>Description:</strong> System identification and signal processing in Matlab and C. Robotic device design.</p>
</div>
</a>
</div>
<div class="project-tile">
<a href="/publications/uw-brl/#haptic-glove">
<div class="project-thumbnail">
<img src="/images/projects/haptic-glove.png" alt="Haptic-Enabled Glove">
</div>
<div class="project-info">
<h3>Haptic-Enabled Glove</h3>
<p><strong>Type:</strong> Hardware Project</p>
<p><strong>Description:</strong> Microcontroller programming, hardware design, and Microsoft Kinect programming.</p>
</div>
</a>
</div>
</div>
</div>
</div>