From 6796256a42003ef9ad5760be9d10e0499eafca3b Mon Sep 17 00:00:00 2001 From: Blaise deB Frederick Date: Sat, 26 Oct 2024 20:02:55 -0400 Subject: [PATCH] Changed default correlation weighting to phat --- docs/exportlist.txt | 3818 +++++++++++++++++++++++ rapidtide/workflows/rapidtide_parser.py | 2 +- 2 files changed, 3819 insertions(+), 1 deletion(-) create mode 100644 docs/exportlist.txt diff --git a/docs/exportlist.txt b/docs/exportlist.txt new file mode 100644 index 00000000..4fa5a29a --- /dev/null +++ b/docs/exportlist.txt @@ -0,0 +1,3818 @@ +@article{RN531, + author = {Anderson, C. M. and Maas, L. C. and Frederick, B. D. and Bendor, J. T. and Spencer, T. J. and Livni, E. and Lukas, S. E. and Fischman, A. J. and Madras, B. K. and Renshaw, P. F. and Kaufman, M. J.}, + title = {Cerebellar vermis participation in cocaine-related behaviors}, + journal = {Neuropsychopharmacology}, + volume = {30}, + pages = {S211-S212}, + note = {Anderson, CM Maas, LC Frederick, BD Bendor, JT Spencer, TJ Livni, E Lukas, SE Fischman, AJ Madras, BK Renshaw, PF Kaufman, MJ +44th Annual Meeting of the American-College-Neuropsychopharmacology +DEC 11-15, 2005 +Waikoloa, HI +Vanderbilt Univ Sch Med Dept Psychiat +1}, + ISSN = {0893-133X}, + url = {://WOS:000233442100547}, + year = {2005}, + type = {Journal Article} +} + +@article{RN539, + author = {Anderson, C. M. and Maas, L. C. and Frederick, B. D. and Bendor, J. T. and Spencer, T. J. and Livni, E. and Lukas, S. E. and Fischman, A. J. and Madras, B. K. and Renshaw, P. F. and Kaufman, M. J.}, + title = {Cerebellar vermis involvement in cocaine-related behaviors}, + journal = {Neuropsychopharmacology}, + volume = {31}, + number = {6}, + pages = {1318-1326}, + note = {Anderson, CM Maas, LC Frederick, BD Bendor, JT Spencer, TJ Livni, E Lukas, SE Fischman, AJ Madras, BK Renshaw, PF Kaufman, MJ +67th Annual Scientific Meeting of the College-on-Problems-of-Drug-Dependence +2005 +Quebec City, CANADA +Coll Problems Drug Dependence}, + abstract = {Although the cerebellum is increasingly being viewed as a brain area involved in cognition, it typically is excluded from circuitry considered to mediate stimulant-associated behaviors since it is low in dopamine. Yet, the primate cerebellar vermis (lobules II-III and VIII-IX) has been reported to contain axonal dopamine transporter immunoreactivity (DAT-IR). We hypothesized that DAT-IR-containing vermis areas would be activated in cocaine abusers by cocaine-related cues and, in healthy humans, would accumulate DAT-selective ligands. We used BOLD fMRI to determine whether cocaine-related cues activated DAT-IR-enriched vermis regions in cocaine abusers and positron emission tomography imaging of healthy humans to determine whether the DAT-selective ligand [C-11] altropane accumulated in those vermis regions. Cocaine-related cues selectively induced BOLD activation in lobules II-III and VIII-IX in cocaine users, and, at early time points after ligand administration, we found appreciable [C-11] altropane accumulation in lobules VIII-IX, possibly indicating DAT presence in this region. These data suggest that parts of cerebellar vermis mediate cocaine's persisting and acute effects. In light of prior findings illustrating vermis connections to midbrain dopamine cell body regions, established roles for the vermis as a locus of sensorimotor integration and motor planning, and findings of increased vermis activation in substance abusers during reward-related and other cognitive tasks, we propose that the vermis be considered one of the structures involved in cocaine- and other incentive-related behaviors.}, + ISSN = {0893-133X}, + DOI = {10.1038/sj.npp.1300937}, + url = {://WOS:000237899600020}, + year = {2006}, + type = {Journal Article} +} + +@article{RN3668, + author = {Anderson, C. M. and Maas, L. C. and Frederick, Bd and Bendor, J. T. and Spencer, T. J. and Livni, E. and Lukas, S. E. and Fischman, A. J. and Madras, B. K. and Renshaw, P. F. and Kaufman, M. J.}, + title = {Cerebellar vermis involvement in cocaine-related behaviors}, + journal = {Neuropsychopharmacology}, + volume = {31}, + number = {6}, + pages = {1318-26}, + note = {Anderson, Carl M +Maas, Luis C +Frederick, Blaise deB +Bendor, Jacob T +Spencer, Thomas J +Livni, Eli +Lukas, Scott E +Fischman, Alan J +Madras, Bertha K +Renshaw, Perry F +Kaufman, Marc J +eng +DA00343/DA/NIDA NIH HHS/ +DA006303/DA/NIDA NIH HHS/ +DA009448/DA/NIDA NIH HHS/ +DA014178/DA/NIDA NIH HHS/ +DA014674/DA/NIDA NIH HHS/ +DA015116/DA/NIDA NIH HHS/ +DA015305/DA/NIDA NIH HHS/ +DA016222/DA/NIDA NIH HHS/ +DA017324/DA/NIDA NIH HHS/ +DA03994/DA/NIDA NIH HHS/ +DA14013/DA/NIDA NIH HHS/ +DA16746/DA/NIDA NIH HHS/ +MH31862/MH/NIMH NIH HHS/ +NS31862/NS/NINDS NIH HHS/ +RR000168/RR/NCRR NIH HHS/ +Clinical Trial +Comparative Study +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +England +Neuropsychopharmacology. 2006 Jun;31(6):1318-26. doi: 10.1038/sj.npp.1300937.}, + abstract = {Although the cerebellum is increasingly being viewed as a brain area involved in cognition, it typically is excluded from circuitry considered to mediate stimulant-associated behaviors since it is low in dopamine. Yet, the primate cerebellar vermis (lobules II-III and VIII-IX) has been reported to contain axonal dopamine transporter immunoreactivity (DAT-IR). We hypothesized that DAT-IR-containing vermis areas would be activated in cocaine abusers by cocaine-related cues and, in healthy humans, would accumulate DAT-selective ligands. We used BOLD fMRI to determine whether cocaine-related cues activated DAT-IR-enriched vermis regions in cocaine abusers and positron emission tomography imaging of healthy humans to determine whether the DAT-selective ligand [11C]altropane accumulated in those vermis regions. Cocaine-related cues selectively induced BOLD activation in lobules II-III and VIII-IX in cocaine users, and, at early time points after ligand administration, we found appreciable [11C]altropane accumulation in lobules VIII-IX, possibly indicating DAT presence in this region. These data suggest that parts of cerebellar vermis mediate cocaine's persisting and acute effects. In light of prior findings illustrating vermis connections to midbrain dopamine cell body regions, established roles for the vermis as a locus of sensorimotor integration and motor planning, and findings of increased vermis activation in substance abusers during reward-related and other cognitive tasks, we propose that the vermis be considered one of the structures involved in cocaine- and other incentive-related behaviors.}, + keywords = {Adult +Aged +Autoradiography/methods +Brain Mapping +Carbon Isotopes/pharmacokinetics +Cerebellum/blood supply/drug effects/*pathology +Cocaine/analogs & derivatives/pharmacokinetics +Cocaine-Related Disorders/*pathology/physiopathology +Female +Humans +Image Processing, Computer-Assisted/methods +In Vitro Techniques +Magnetic Resonance Imaging/methods +Male +Oxygen/blood +Positron-Emission Tomography +Postmortem Changes}, + ISSN = {0893-133X (Print) +0893-133X (Linking)}, + DOI = {10.1038/sj.npp.1300937}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16237382}, + year = {2006}, + type = {Journal Article} +} + +@article{RN525, + author = {Christensen, J. D. and Kaufman, M. J. and Frederick, B. D. and Rose, S. L. and Moore, C. M. and Lukas, S. E. and Mendelson, J. H. and Cohen, B. M. and Renshaw, P. F.}, + title = {Proton magnetic resonance spectroscopy of human basal ganglia: Response to cocaine administration}, + journal = {Biological Psychiatry}, + volume = {48}, + number = {7}, + pages = {685-692}, + note = {Christensen, JD Kaufman, MJ Frederick, BD Rose, SL Moore, CM Lukas, SE Mendelson, JH Cohen, BM Renshaw, PF}, + abstract = {Background: Proton magnetic resonance spectroscopy was used to determine the effects of intravenous cocaine or placebo administration on human basal ganglia water and metabolite resonances. Methods: Long echo time, proton magnetic resonance spectra of water and intracellular metabolites were continuously acquired from an 8-cm(3) voxel centered on the left caudate and putamen nuclei before, during, and after the intravenous administration of cocaine or a placebo in a double-blind manner. Results: Cocaine, at both 0.2 and 0.4 mg/kg, did not alter the peak area for water. Cocaine at 0.2 mg/kg induced small and reversible increases in choline-containing compounds and N-acetylaspartate peak areas. Cocaine at 0.4 mg/kg induced larger and more sustained increases in choline-containing compounds and N-acetylaspartate peak areas. No changes in either water or metabolite resonances were noted following placebo administration, Conclusions: These increases in choline-containing compounds and N-acetylaspartate peak areas may reflect increases in metabolite T2 relaxation times secondary to osmotic stress and/or increased phospholipid signaling within the basal ganglia following cocaine administration. This is the first report of acute, drug-induced changes in the intensity of human brain proton magnetic resonance spectroscopy resonance areas. (C) 2000 Society of Biological Psychiatry.}, + ISSN = {0006-3223}, + DOI = {10.1016/s0006-3223(00)00897-0}, + url = {://WOS:000089953100007}, + year = {2000}, + type = {Journal Article} +} + +@article{RN3625, + author = {Cogswell, P. M. and Davis, T. L. and Strother, M. K. and Faraco, C. C. and Scott, A. O. and Jordan, L. C. and Fusco, M. R. and Frederick, B. D. and Hendrikse, J. and Donahue, M. J.}, + title = {Impact of vessel wall lesions and vascular stenoses on cerebrovascular reactivity in patients with intracranial stenotic disease}, + journal = {J Magn Reson Imaging}, + volume = {46}, + number = {4}, + pages = {1167-1176}, + note = {Cogswell, Petrice M +Davis, Taylor L +Strother, Megan K +Faraco, Carlos C +Scott, Allison O +Jordan, Lori C +Fusco, Matthew R +Frederick, Blaise deB +Hendrikse, Jeroen +Donahue, Manus J +eng +R01 NS097763/NS/NINDS NIH HHS/ +T32 EB001628/EB/NIBIB NIH HHS/ +R01 NS097512/NS/NINDS NIH HHS/ +U54 HD083211/HD/NICHD NIH HHS/ +R01 NS078828/NS/NINDS NIH HHS/ +J Magn Reson Imaging. 2017 Oct;46(4):1167-1176. doi: 10.1002/jmri.25602. Epub 2017 Jan 6.}, + abstract = {PURPOSE: To compare cerebrovascular reactivity (CVR) and CVR lagtimes in flow territories perfused by vessels with vs. without proximal arterial wall disease and/or stenosis, separately in patients with atherosclerotic and nonatherosclerotic (moyamoya) intracranial stenosis. MATERIALS AND METHODS: Atherosclerotic and moyamoya patients with >50% intracranial stenosis and <70% cervical stenosis underwent angiography, vessel wall imaging (VWI), and CVR-weighted imaging (n = 36; vessel segments evaluated = 396). Angiography and VWI were evaluated for stenosis locations and vessel wall lesions. Maximum CVR and CVR lagtime were contrasted between vascular territories with and without proximal intracranial vessel wall lesions and stenosis, and a Wilcoxon rank-sum was test used to determine differences (criteria: corrected two-sided P < 0.05). RESULTS: CVR lagtime was prolonged in territories with vs. without a proximal vessel wall lesion or stenosis for both patient groups: moyamoya (CVR lagtime = 45.5 sec +/- 14.2 sec vs. 35.7 sec +/- 9.7 sec, P < 0.001) and atherosclerosis (CVR lagtime = 38.2 sec +/- 9.1 sec vs. 35.0 sec +/- 7.2 sec, P = 0.001). For reactivity, a significant decrease in maximum CVR in the moyamoya group only (maximum CVR = 9.8 +/- 2.2 vs. 12.0 +/- 2.4, P < 0.001) was observed. CONCLUSION: Arterial vessel wall lesions detected on noninvasive, noncontrast intracranial VWI in patients with intracranial stenosis correlate on average with tissue-level impairment on CVR-weighted imaging. LEVEL OF EVIDENCE: 4 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1167-1176.}, + keywords = {Adult +Aged +Aged, 80 and over +Atherosclerosis/*diagnostic imaging/physiopathology +Cerebral Arterial Diseases/*diagnostic imaging/physiopathology +Cerebral Arteries/diagnostic imaging/*physiopathology +Constriction, Pathologic/diagnostic imaging/physiopathology +Female +Humans +Magnetic Resonance Angiography/*methods +Male +Middle Aged +Moyamoya Disease/diagnostic imaging +Plaque, Atherosclerotic/*diagnostic imaging/physiopathology +cerebrovascular reactivity +intracranial stenosis +moyamoya +vessel wall imaging}, + ISSN = {1522-2586 (Electronic) +1053-1807 (Linking)}, + DOI = {10.1002/jmri.25602}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/28061015}, + year = {2017}, + type = {Journal Article} +} + +@article{RN2795, + author = {Copersino, M. L. and Price, J. S. and Frost, K. H. and Vitaliano, G. D. and Frederick, B. D. and Lukas, S. E. and Weiss, R. D. and Janes, A. C.}, + title = {Default Mode Network Functional Reorganization During Early Abstinence in Polysubstance-Using Emerging Adults Treated for Opioid Dependence}, + journal = {J Neuropsychiatry Clin Neurosci}, + volume = {28}, + number = {4}, + pages = {appineuropsych15090240}, + note = {Copersino, Marc L +Price, Jenessa S +Frost, Katherine H +Vitaliano, Gordana D +Frederick, Blaise deB +Lukas, Scott E +Weiss, Roger D +Janes, Amy C +eng +K01 DA029645/DA/NIDA NIH HHS/ +K23 DA027045/DA/NIDA NIH HHS/ +K24 DA022288/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +K08 DA037465/DA/NIDA NIH HHS/ +J Neuropsychiatry Clin Neurosci. 2016 Jan 21:appineuropsych15090240. doi: 10.1176/appi.neuropsych.15090240.}, + abstract = {This study examined default mode network connectivity within the first 30 days of abstinence in emerging adults entering treatment for opioid dependence. There were significant associations between abstinence duration and coupling strength with brain regions within and outside of the network.}, + ISSN = {1545-7222 (Electronic) +0895-0172 (Linking)}, + DOI = {10.1176/appi.neuropsych.15090240}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/26792100}, + year = {2016}, + type = {Journal Article} +} + +@article{RN3635, + author = {Cowan, R. L. and Frederick, B. B. and Rainey, M. and Levin, J. M. and Maas, L. C. and Bang, J. and Hennen, J. and Lukas, S. E. and Renshaw, P. F.}, + title = {Sex differences in response to red and blue light in human primary visual cortex: a bold fMRI study}, + journal = {Psychiatry Res}, + volume = {100}, + number = {3}, + pages = {129-38}, + note = {Cowan, R L +Frederick, B B +Rainey, M +Levin, J M +Maas, L C +Bang, J +Hennen, J +Lukas, S E +Renshaw, P F +eng +DA 00366-01/DA/NIDA NIH HHS/ +DA00343/DA/NIDA NIH HHS/ +DA09448/DA/NIDA NIH HHS/ +Research Support, U.S. Gov't, P.H.S. +Ireland +Psychiatry Res. 2000 Dec 22;100(3):129-38.}, + abstract = {Studies using a variety of investigative methods, including functional brain imaging and electroencephalography (EEG), have suggested that changes in central nervous system (CNS) dopamine function result in altered visual system processing. The discovery of abnormal retinal blue cone, but not red cone, electroretinogram in association with cocaine withdrawal and Parkinson's disease suggests that visual system response to blue light might be a marker for CNS dopamine tone. As there are numerous sex-related differences in central nervous system dopamine function, we predicted that blue and red light stimulation would produce sex-specific patterns of response in primary visual cortex when studied using the blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) technique. We analyzed the BOLD response to red and blue light in male and female human volunteers (N=20). Red and blue light responses in primary visual cortex (V1) to stepped intensities of red and blue light were compared by sex for threshold to detectable BOLD signal increase and for stimulus intensity vs. BOLD signal response. Near threshold, males and females showed similar BOLD signal change to red light, but males showed a threefold greater increase (0.52%) to blue light stimulation when compared to females (0.14%). Log-linear regression modeling revealed that the slope coefficients for the red light stimulus intensity vs. signal change curve were not significantly different for males and females (z=0.995, P=0.320), whereas the slope coefficients for the blue light stimulus intensity vs. signal change curve were significantly larger in males (z=2.251, P=0.024). These findings support a sex and color-dependent differential pattern of primary visual cortical response to photic stimulation and suggest a method for assessing the influence of specific dopamine agonist/antagonist medications on visual function.}, + keywords = {Adult +Brain Mapping +Color Perception/*physiology +Dopamine/physiology +Estrogens/physiology +Female +Humans +Image Enhancement +*Magnetic Resonance Imaging +Male +Oxygen/blood +Photic Stimulation +Sensory Thresholds/physiology +Sex Factors +Visual Cortex/*physiology}, + ISSN = {0165-1781 (Print) +0165-1781 (Linking)}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/11120440}, + year = {2000}, + type = {Journal Article} +} + +@article{RN524, + author = {Cowan, R. L. and Frederick, B. D. and Rainey, M. and Levin, J. M. and Maas, L. C. and Bang, J. and Hennen, J. and Lukas, S. E. and Renshaw, P. F.}, + title = {Sex differences in response to red and blue light in human primary visual cortex: a bold fMRI study}, + journal = {Psychiatry Research-Neuroimaging}, + volume = {100}, + number = {3}, + pages = {129-138}, + note = {Cowan, RL Frederick, BD Rainey, M Levin, JM Maas, LC Bang, J Hennen, J Lukas, SE Renshaw, PF}, + abstract = {Studies using a variety of investigative methods, including functional brain imaging and electroencephalography (EEG), have suggested that changes in central nervous system (CNS) dopamine function result in altered visual system processing. The discovery of abnormal retinal blue cone, but not red cone, electroretinogram in association with cocaine withdrawal and Parkinson's disease suggests that visual system response to blue light might he a marker for CNS dopamine tone. As there are numerous sex-related differences in central nervous system dopamine function, we predicted that blue and red light stimulation would produce sex-specific patterns of response in primary visual cortex when studied using the blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) technique. We analyzed the BOLD response to red and blue light in male and female human volunteers (N = 20). Red and blue light responses in primary visual cortex (V1) to stepped intensities of red and blue light were compared by sex for threshold to detectable BOLD signal increase and for stimulus intensity vs. BOLD signal response. Near threshold, males and females showed similar BOLD signal change to red light, but males showed a threefold greater increase (0.52%) to blue light stimulation when compared to females (0.14%). Log-linear regression modeling revealed that the slope coefficients for the red light stimulus intensity vs. signal change curve were not significantly different for males and females (z = 0.995, P = 0.320), whereas the slope coefficients for the blue light stimulus intensity vs. signal change curve were significantly larger in males(z = 2.251, P = 0.024). These findings support a sex and color-dependent differential pattern of primary visual cortical response to photic stimulation and suggest a method for assessing the influence of specific dopamine agonist/antagonist medications on visual function. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.}, + ISSN = {0925-4927}, + DOI = {10.1016/s0925-4927(00)00074-3}, + url = {://WOS:000166450600001}, + year = {2000}, + type = {Journal Article} +} + +@article{RN3667, + author = {Cowan, R. L. and Haga, E. and de, B. Frederick B. and Dietrich, M. S. and Vimal, R. L. and Lukas, S. E. and Renshaw, P. F.}, + title = {MDMA use is associated with increased spatial BOLD fMRI visual cortex activation in human MDMA users}, + journal = {Pharmacol Biochem Behav}, + volume = {84}, + number = {2}, + pages = {219-28}, + note = {Cowan, R L +Haga, E +deB Frederick, B +Dietrich, M S +Vimal, R L P +Lukas, S E +Renshaw, P F +eng +DA00343/DA/NIDA NIH HHS/ +DA00366/DA/NIDA NIH HHS/ +DA015137/DA/NIDA NIH HHS/ +DA03994/DA/NIDA NIH HHS/ +DA09448/DA/NIDA NIH HHS/ +DA14013/DA/NIDA NIH HHS/ +DA14178/DA/NIDA NIH HHS/ +DA15116/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +Pharmacol Biochem Behav. 2006 Jun;84(2):219-28. doi: 10.1016/j.pbb.2006.04.024. Epub 2006 Jun 19.}, + abstract = {Previous animal studies have demonstrated that 3,4-methylenedioxymethamphetamine (MDMA) exposure causes serotonin axotomy that is greatest in occipital cortex (including primary visual cortex) where serotonergic axons innervate neurons and blood vessels. Human MDMA users have altered serotonergic function and reduced gray matter density in occipital cortex. The fMRI BOLD method is potentially sensitive to both the neuronal and vascular consequences of MDMA-induced serotonin toxicity. To test the hypothesis that MDMA users have altered visual system function, we used the fMRI BOLD technique to assay visual cortical activation after photic stimulation in a group of adult MDMA users. Because MDMA users worldwide are polydrug users and therefore difficult to match to comparison groups in terms of polydrug exposure, we conducted a primary within-group analysis examining the correlation between lifetime episodes of MDMA exposure and measures of visual cortical activation. The within-group correlational analysis in the MDMA user group revealed that the degree of prior MDMA exposure was significantly positively correlated with the number of activated pixels for photic stimulation (r=0.582, p=0.007). A secondary between-group comparison of MDMA users with non-MDMA users found overall greater levels of polydrug exposure in the MDMA user cohort but no significant differences in visual cortical activation measures between the two groups. Additional research is needed to clarify the origin and significance of the current findings.}, + keywords = {Adolescent +Adult +Female +Humans +Magnetic Resonance Imaging +Male +N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects +Photic Stimulation +Substance-Related Disorders/*physiopathology +Visual Cortex/*drug effects/*physiology}, + ISSN = {0091-3057 (Print) +0091-3057 (Linking)}, + DOI = {10.1016/j.pbb.2006.04.024}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16782178}, + year = {2006}, + type = {Journal Article} +} + +@article{RN540, + author = {Cowan, R. L. and Haga, E. and Frederick, B. D. and Dietrich, M. S. and Vimal, R. L. P. and Lukas, S. E. and Renshaw, R.}, + title = {MDMA use is associated with increased spatial BOLD fMRI visual cortex activation in human MDMA users}, + journal = {Pharmacology Biochemistry and Behavior}, + volume = {84}, + number = {2}, + pages = {219-228}, + note = {Cowan, R. L. Haga, E. Frederick, B. DeB Dietrich, M. S. Vimal, R. L. P. Lukas, S. E. Renshaw, P. F.}, + abstract = {Previous animal studies have demonstrated that 3,4-methylenedioxymethamphetamine (MDMA) exposure causes serotonin axotomy that is greatest in occipital cortex (including primary visual cortex) where serotonergic axons innervate neurons and blood vessels. Human MDMA users have altered serotonergic function and reduced gray matter density in occipital cortex. The fMRI BOLD method is potentially sensitive to both the neuronal and vascular consequences of MDMA-induced serotonin toxicity. To test the hypothesis that MDMA users have altered visual system function, we used the fMRI BOLD technique to assay visual cortical activation after photic stimulation in a group of adult MDMA users. Because MDMA users worldwide are polydrug users and therefore difficult to match to comparison groups in terms of polydrug exposure, we conducted a primary within-group analysis examining the correlation between lifetime episodes of MDMA exposure and measures of visual cortical activation. The within-group cot-relational analysis in the MDMA user group revealed that the degree of prior MDMA exposure was significantly positively correlated with the number of activated pixels for photic stimulation (r=0.582, p=0.007). A secondary between-group comparison of MDMA users with non-MDMA users found overall greater levels of polydrug exposure in the MDMA user cohort but no significant differences in visual cortical activation measures between the two groups. Additional research is needed to clarify the origin and significance of the current findings. (c) 2006 Elsevier Inc. All rights reserved.}, + ISSN = {0091-3057}, + DOI = {10.1016/j.pbb.2006.04.024}, + url = {://WOS:000239856400005}, + year = {2006}, + type = {Journal Article} +} + +@article{RN3636, + author = {Cowan, R. L. and Wood, J. and Dietrich, M. S. and de, B. Frederick B. and Lukas, S. E. and Renshaw, P. F.}, + title = {Differential effects of D-amphetamine on red and blue light-induced photic activation: A novel BOLD fMRI assay of human dopamine function}, + journal = {Synapse}, + volume = {62}, + number = {4}, + pages = {268-72}, + note = {Cowan, Ronald L +Wood, Julia +Dietrich, Mary S +de B Frederick, Blaise +Lukas, Scott E +Renshaw, Perry F +eng +DA 00,343/DA/NIDA NIH HHS/ +DA 00,366-01/DA/NIDA NIH HHS/ +DA 09,448/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Synapse. 2008 Apr;62(4):268-72. doi: 10.1002/syn.20491.}, + abstract = {The neurotransmitter dopamine (DA) is implicated in the pathophysiology of central nervous system (CNS) illnesses including Parkinson's disease, attention deficit disorder, schizophrenia, and substance abuse. A better understanding of CNS DA function would be of importance in improving our understanding of these conditions. Several lines of evidence suggest that exploring visual system function may be a useful paradigm for examining DA function. Clinical and basic science findings suggest that the visual response to blue light might prove a useful assay of CNS DA tone. To test this hypothesis, we used the functional magnetic resonance imaging (fMRI) BOLD method to measure visual cortical activation in human subjects (N = 6) in response to 8 Hz flashing red and blue light stimuli during placebo conditions and during the oral administration of 2.5 mg of D-amphetamine, a drug known to increase synaptic concentrations of DA and other monoamine neurotransmitters. There was no effect of D-amphetamine administration on the percent BOLD signal change to red or blue light. However, there was a specific augmentation of the spatial extent of activation (as measured by the number of activated pixels; P = 0.018) to blue, but not red light following D-amphetamine administration. This finding is consistent with our hypothesis that blue light function may have utility as an assay of CNS DA tone. However, several limitations to the study, including the small sample size, low dosage of D-amphetamine, and the fact that D-amphetamine increases synaptic concentrations of DA and other monoamine neurotransmitters do not permit a conclusion regarding a specific role for DA in the observed increase in spatial activation to blue light in the amphetamine condition.}, + keywords = {Adult +Central Nervous System Stimulants/*pharmacology +Dextroamphetamine/*pharmacology +Dopamine/*metabolism +Female +Humans +Light +Magnetic Resonance Imaging +Male +*Photic Stimulation/methods +Visual Cortex/*drug effects/physiology}, + ISSN = {0887-4476 (Print) +0887-4476 (Linking)}, + DOI = {10.1002/syn.20491}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/18240321}, + year = {2008}, + type = {Journal Article} +} + +@article{RN543, + author = {Cowan, R. L. and Wood, J. and Dietrich, M. S. and Frederick, B. D. and Lukas, S. E. and Renshaw, P. F.}, + title = {Differential effects of D-amphetamine on red and blue light-induced photic activation: A novel BOLD fMRI assay of human dopamine function}, + journal = {Synapse}, + volume = {62}, + number = {4}, + pages = {268-272}, + note = {Cowan, Ronald L. Wood, Julia Dietrich, Mary S. Frederick, Blaise de. B. Lukas, Scott E. Renshaw, Perry F.}, + abstract = {The neurotransmitter dopamine (DA) is implicated in the pathophysiology of central nervous system (CNS) illnesses including Parkinson's disease, attention deficit disorder, schizophrenia, and substance abuse. A better understanding of CNS DA function would be of importance in improving our understanding of these conditions. Several lines of evidence suggest that exploring visual system function may be a useful paradigm for examining DA function. Clinical and basic science findings suggest that the visual response to blue light might prove a useful assay of CNS DA tone. To test this hypothesis, we used the functional magnetic resonance imaging (fMRI) BOLD method to measure visual cortical activation in human subjects (N = 6) in response to 8 Hz flashing red and blue light stimuli during placebo conditions and during the oral administration of 2.5 mg of D-amphetamine, a drug known to increase synaptic concentrations of DA and other monoamine neurotransmitters. There was no effect Of D-amphetamine administration on the percent BOLD signal change to red or blue light. However, there was a specific augmentation of the spatial extent of activation (as measured by the number of activated pixels; P = 0.018) to blue, but not red light following D-amphetamine administration. This finding is consistent with our hypothesis that blue light function may have utility as an assay of CNS DA tone. However, several limitations to the study, including the small sample size, low dosage of D-amphetamine, and the fact that D-amphetamine increases synaptic concentrations of DA and other monoamine neurotransmitters do not permit a conclusion regarding a specific role for DA in the observed increase in spatial activation to blue light in the amphetamine condition.}, + ISSN = {0887-4476}, + DOI = {10.1002/syn.20491}, + url = {://WOS:000254040200005}, + year = {2008}, + type = {Journal Article} +} + +@article{RN564, + author = {Deligiannidis, K. M. and Sikoglu, E. M. and Shaffer, S. A. and Frederick, B. and Svenson, A. E. and Kopoyan, A. and Kosma, C. A. and Rothschild, A. J. and Moore, C. M.}, + title = {GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study}, + journal = {J Psychiatr Res}, + volume = {47}, + number = {6}, + pages = {816-28}, + abstract = {Postpartum depression (PPD) affects up to 1 in 8 women. The early postpartum period is characterized by a downward physiological shift from relatively elevated levels of sex steroids during pregnancy to diminished levels after parturition. Sex steroids influence functional brain connectivity in healthy non-puerperal subjects. This study tests the hypothesis that PPD is associated with attenuation of resting-state functional connectivity (rs-fc) within corticolimbic regions implicated in depression and alterations in neuroactive steroid concentrations as compared to healthy postpartum women. Subjects (n = 32) were prospectively evaluated during pregnancy and in the postpartum with repeated plasma neuroactive steroid measurements and mood and psychosocial assessments. Healthy comparison subjects (HCS) and medication-free subjects with unipolar PPD (PPD) were examined using functional magnetic resonance imaging (fMRI) within 9 weeks of delivery. We performed rs-fc analysis with seeds placed in the anterior cingulate cortex (ACC), and bilateral amygdala (AMYG), hippocampi (HIPP) and dorsolateral prefrontal cortices (DLPFCs). Postpartum rs-fc and perinatal neuroactive steroid plasma concentrations, quantified by liquid chromatography/mass spectrometry, were compared between groups. PPD subjects showed attenuation of connectivity for each of the tested regions (i.e. ACC, AMYG, HIPP and DLPFC) and between corticocortical and corticolimbic regions vs. HCS. Perinatal concentrations of pregnanolone, allopregnanolone and pregnenolone were not different between groups. This is the first report of a disruption in the rs-fc patterns in medication-free subjects with PPD. This disruption may contribute to the development of PPD, at a time of falling neuroactive steroid concentrations.}, + ISSN = {1879-1379}, + DOI = {10.1016/j.jpsychires.2013.02.010}, + url = {http://www.ncbi.nlm.nih.gov/pubmed/23499388}, + year = {2013}, + type = {Journal Article} +} + +@article{RN3639, + author = {Deligiannidis, K. M. and Sikoglu, E. M. and Shaffer, S. A. and Frederick, B. and Svenson, A. E. and Kopoyan, A. and Kosma, C. A. and Rothschild, A. J. and Moore, C. M.}, + title = {GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study}, + journal = {J Psychiatr Res}, + volume = {47}, + number = {6}, + pages = {816-28}, + note = {Deligiannidis, Kristina M +Sikoglu, Elif M +Shaffer, Scott A +Frederick, Blaise +Svenson, Abby E +Kopoyan, Andre +Kosma, Chelsea A +Rothschild, Anthony J +Moore, Constance M +eng +K23 MH097794/MH/NIMH NIH HHS/ +L30 MH104713/MH/NIMH NIH HHS/ +R01 MH073998/MH/NIMH NIH HHS/ +UL1 TR000161/TR/NCATS NIH HHS/ +Research Support, Non-U.S. Gov't +England +J Psychiatr Res. 2013 Jun;47(6):816-28. doi: 10.1016/j.jpsychires.2013.02.010. Epub 2013 Mar 15.}, + abstract = {Postpartum depression (PPD) affects up to 1 in 8 women. The early postpartum period is characterized by a downward physiological shift from relatively elevated levels of sex steroids during pregnancy to diminished levels after parturition. Sex steroids influence functional brain connectivity in healthy non-puerperal subjects. This study tests the hypothesis that PPD is associated with attenuation of resting-state functional connectivity (rs-fc) within corticolimbic regions implicated in depression and alterations in neuroactive steroid concentrations as compared to healthy postpartum women. Subjects (n = 32) were prospectively evaluated during pregnancy and in the postpartum with repeated plasma neuroactive steroid measurements and mood and psychosocial assessments. Healthy comparison subjects (HCS) and medication-free subjects with unipolar PPD (PPD) were examined using functional magnetic resonance imaging (fMRI) within 9 weeks of delivery. We performed rs-fc analysis with seeds placed in the anterior cingulate cortex (ACC), and bilateral amygdala (AMYG), hippocampi (HIPP) and dorsolateral prefrontal cortices (DLPFCs). Postpartum rs-fc and perinatal neuroactive steroid plasma concentrations, quantified by liquid chromatography/mass spectrometry, were compared between groups. PPD subjects showed attenuation of connectivity for each of the tested regions (i.e. ACC, AMYG, HIPP and DLPFC) and between corticocortical and corticolimbic regions vs. HCS. Perinatal concentrations of pregnanolone, allopregnanolone and pregnenolone were not different between groups. This is the first report of a disruption in the rs-fc patterns in medication-free subjects with PPD. This disruption may contribute to the development of PPD, at a time of falling neuroactive steroid concentrations.}, + keywords = {Adult +Amygdala/physiopathology +Depression, Postpartum/blood/*physiopathology +Female +Gyrus Cinguli/physiopathology +Hippocampus/physiopathology +Humans +Magnetic Resonance Imaging/instrumentation/*methods +Nerve Net/*physiopathology +Pilot Projects +Postpartum Period +Prefrontal Cortex/physiopathology +Pregnancy +Pregnanolone/*blood +Pregnenolone/*blood}, + ISSN = {1879-1379 (Electronic) +0022-3956 (Linking)}, + DOI = {10.1016/j.jpsychires.2013.02.010}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/23499388}, + year = {2013}, + type = {Journal Article} +} + +@article{RN2630, + author = {Donahue, M. J. and Strother, M. K. and Lindsey, K. P. and Hocke, L. M. and Tong, Y. and Frederick, B. D.}, + title = {Time delay processing of hypercapnic fMRI allows quantitative parameterization of cerebrovascular reactivity and blood flow delays}, + journal = {J Cereb Blood Flow Metab}, + volume = {36}, + number = {10}, + pages = {1767-1779}, + note = {Donahue, Manus J +Strother, Megan K +Lindsey, Kimberly P +Hocke, Lia M +Tong, Yunjie +Frederick, Blaise deB +eng +R21 DA032746/DA/NIDA NIH HHS/ +J Cereb Blood Flow Metab. 2016 Oct;36(10):1767-1779. doi: 10.1177/0271678X15608643. Epub 2015 Oct 19.}, + abstract = {Blood oxygenation level-dependent fMRI contrast depends on the volume and oxygenation of blood flowing through the circulatory system. The effects on image intensity depend temporally on the arrival of blood within a voxel, and signal can be monitored during the time course of such blood flow. It has been previously shown that the passage of global endogenous variations in blood volume and oxygenation can be tracked as blood passes through the brain by determining the strength and peak time lag of their cross-correlation with blood oxygenation level-dependent data. By manipulating blood composition using transient hypercarbia and hyperoxia, we can induce much larger oxygenation and volume changes in the blood oxygenation level-dependent signal than result from natural endogenous fluctuations. This technique was used to examine cerebrovascular parameters in healthy subjects (n = 8) and subjects with intracranial stenosis (n = 22), with a subgroup of intracranial stenosis subjects scanned before and after surgical revascularization (n = 6). The halfwidth of cross-correlation lag times in the brain was larger in IC stenosis subjects (21.21 +/- 14.22 s) than in healthy control subjects (8.03 +/- 3.67), p < 0.001, and was subsequently reduced in regions that co-localized with surgical revascularization. These data show that blood circulatory timing can be measured robustly and longitudinally throughout the brain using simple respiratory challenges.}, + keywords = {Adult +Blood Flow Velocity/*physiology +Brain/blood supply/*diagnostic imaging/pathology/physiopathology +Carbon Dioxide/blood +Case-Control Studies +Cerebrovascular Circulation/*physiology +Cerebrovascular Disorders/*diagnostic imaging/pathology/physiopathology +Constriction, Pathologic +Female +Humans +Hypercapnia/*diagnostic imaging/physiopathology +Magnetic Resonance Imaging/*methods +Male +Oxygen/blood +Time Factors +Atherosclerosis +cerebral blood flow +cerebrovascular disease +fMRI +moyamoya +surgery/endarterectomy}, + ISSN = {1559-7016 (Electronic) +0271-678X (Linking)}, + DOI = {10.1177/0271678X15608643}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/26661192}, + year = {2016}, + type = {Journal Article} +} + +@article{RN541, + author = {Eliassen, J. C. and Adler, C. M. and Yurgelun-Todd, D. and Renshaw, P. F. and Gruber, S. and Olson, D. and Frederick, B. and Bain, E. E. and Kujawa, M. and Gharabawi, G. and Strakowski, S. M.}, + title = {Changes in fMRI brain activation in frequently relapsing bipolar patients created with long-acting injectable risperidone}, + journal = {Biological Psychiatry}, + volume = {59}, + number = {8}, + pages = {97S-97S}, + note = {Eliassen, JC Adler, CM Yurgelun-Todd, D Renshaw, PF Gruber, S Olson, D Frederick, B Bain, EE Kujawa, M Gharabawi, G Strakowski, SM +61st Annual Convention of the Society-of-Biological-Psychiatry +MAY 18-20, 2006 +Toronto, CANADA +Soc Biol Psychiat +S}, + ISSN = {0006-3223}, + url = {://WOS:000236767300310}, + year = {2006}, + type = {Journal Article} +} + +@article{RN542, + author = {Elman, I. and Frederick, B. and Ariely, D. and Dunlap, S. and Rodolico, J. and Penetar, D. and Mazar, N. and Cohan, J. and Pitman, R. and Lukas, S.}, + title = {Emotional numbing in PTSD: fMRI neuroirnaging of reward circuitry}, + journal = {Neuropsychopharmacology}, + volume = {30}, + pages = {S163-S163}, + note = {Elman, I Frederick, B Ariely, D Dunlap, S Rodolico, J Penetar, D Mazar, N Cohan, J Pitman, R Lukas, S +44th Annual Meeting of the American-College-Neuropsychopharmacology +DEC 11-15, 2005 +Waikoloa, HI +Vanderbilt Univ Sch Med Dept Psychiat +1}, + ISSN = {0893-133X}, + url = {://WOS:000233442100429}, + year = {2005}, + type = {Journal Article} +} + +@article{RN534, + author = {Elman, I. and Frederick, B. and Ariely, D. and Penetar, D. and Juliano, T. and Mazar, N. and Pitman, R. and Lukas, S.}, + title = {Effects of social and monetary stimuli on the reward circuitry activation in healthy volunteers}, + journal = {Neuropsychopharmacology}, + volume = {29}, + pages = {S79-S80}, + note = {Elman, I Frederick, B Ariely, D Penetar, D Juliano, T Mazar, N Pitman, R Lukas, S +Annual Meeting of the American-College-of-Neuropsychopharmacology +DEC 12-16, 2004 +San Juan, PR +Vanderbilt Univ, Sch Med, Dept Psychiaty, Amer Coll Neuropsychopharmacol +1}, + ISSN = {0893-133X}, + url = {://WOS:000225588000235}, + year = {2004}, + type = {Journal Article} +} + +@article{RN552, + author = {Elman, I. and Lowen, S. and Frederick, B. B. and Chi, W. and Becerra, L. and Pitman, R. K.}, + title = {Functional Neuroimaging of Reward Circuitry Responsivity to Monetary Gains and Losses in Posttraumatic Stress Disorder}, + journal = {Biological Psychiatry}, + volume = {66}, + number = {12}, + pages = {1083-1090}, + note = {Elman, Igor Lowen, Steven Frederick, Blaise B. Chi, Won Becerra, Lino Pitman, Roger K.}, + abstract = {Background: Clinical impressions and preclinical work suggest that posttraumatic stress disorder (PTSD) might be associated with dysfunctional reward processing. To pursue this issue, we administered a validated passive-viewing monetary reward task during functional magnetic resonance imaging (fMRI) to subjects with chronic PTSD and to mentally healthy individuals. \Methods: The protocol evaluated fMRI signal changes that anticipated or accompanied monetary gains and losses under varying conditions of controlled expectation. The "expectancy phase" entailed presentation of a promising, unpromising, or intermediate Wheel of Fortune-type spinner, whereas the "outcome phase" was defined by the arrow landing on one of three sectors of that spinner, thereby determining the subjects' gain or loss for that trial. Results: Neuroimaging data from 20 PTSD and 26 healthy subjects withstood quality control procedures and were included. In voxelwise and anatomically defined region-of-interest analyses, when gains were contrasted to losses, between-group comparison revealed smaller bilateral striatal activations in the PTSD subjects. In the PTSD group, less striatal activation to gains versus losses was associated with more self-reported motivational and social deficits. Conclusions: The present data support the hypothesis that PTSD is associated with abnormal processing of monetary outcomes and that this alteration might be related to some aspects of emotional numbing.}, + ISSN = {0006-3223}, + DOI = {10.1016/j.biopsych.2009.06.006}, + url = {://WOS:000272599500003}, + year = {2009}, + type = {Journal Article} +} + +@article{RN501, + author = {Elman, I. and Lowen, S. and Frederick, B. B. and Chi, W. and Becerra, L. and Pitman, R. K.}, + title = {Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder}, + journal = {Biol Psychiatry}, + volume = {66}, + number = {12}, + pages = {1083-90}, + note = {Elman, Igor +Lowen, Steven +Frederick, Blaise B +Chi, Won +Becerra, Lino +Pitman, Roger K +eng +R01 DA017959/DA/NIDA NIH HHS/ +DA017959/DA/NIDA NIH HHS/ +DA16612/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Biol Psychiatry. 2009 Dec 15;66(12):1083-90. doi: 10.1016/j.biopsych.2009.06.006. Epub 2009 Jul 29.}, + abstract = {BACKGROUND: Clinical impressions and preclinical work suggest that posttraumatic stress disorder (PTSD) might be associated with dysfunctional reward processing. To pursue this issue, we administered a validated passive-viewing monetary reward task during functional magnetic resonance imaging (fMRI) to subjects with chronic PTSD and to mentally healthy individuals. METHODS: The protocol evaluated fMRI signal changes that anticipated or accompanied monetary gains and losses under varying conditions of controlled expectation. The "expectancy phase" entailed presentation of a promising, unpromising, or intermediate Wheel of Fortune-type spinner, whereas the "outcome phase" was defined by the arrow landing on one of three sectors of that spinner, thereby determining the subjects' gain or loss for that trial. RESULTS: Neuroimaging data from 20 PTSD and 26 healthy subjects withstood quality control procedures and were included. In voxelwise and anatomically defined region-of-interest analyses, when gains were contrasted to losses, between-group comparison revealed smaller bilateral striatal activations in the PTSD subjects. In the PTSD group, less striatal activation to gains versus losses was associated with more self-reported motivational and social deficits. CONCLUSIONS: The present data support the hypothesis that PTSD is associated with abnormal processing of monetary outcomes and that this alteration might be related to some aspects of emotional numbing.}, + keywords = {Adult +Analysis of Variance +Brain/blood supply/physiopathology +*Brain Mapping +Female +Humans +Image Processing, Computer-Assisted/methods +*Magnetic Resonance Imaging +Male +Memory/physiology +Middle Aged +Nerve Net/*blood supply +Oxygen/blood +*Reward +Stress Disorders, Post-Traumatic/*pathology/physiopathology +Time Factors +Young Adult}, + ISSN = {1873-2402 (Electronic) +0006-3223 (Linking)}, + DOI = {10.1016/j.biopsych.2009.06.006}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/19640506}, + year = {2009}, + type = {Journal Article} +} + +@article{RN2636, + author = {Erdogan, S. B. and Tong, Y. and Hocke, L. M. and Lindsey, K. P. and de, B. Frederick B.}, + title = {Correcting for Blood Arrival Time in Global Mean Regression Enhances Functional Connectivity Analysis of Resting State fMRI-BOLD Signals}, + journal = {Front Hum Neurosci}, + volume = {10}, + number = {1024}, + pages = {311}, + note = {Erdogan, Sinem B +Tong, Yunjie +Hocke, Lia M +Lindsey, Kimberly P +deB Frederick, Blaise +eng +K25 DA031769/DA/NIDA NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +Switzerland +Front Hum Neurosci. 2016 Jun 28;10:311. doi: 10.3389/fnhum.2016.00311. eCollection 2016.}, + abstract = {Resting state functional connectivity analysis is a widely used method for mapping intrinsic functional organization of the brain. Global signal regression (GSR) is commonly employed for removing systemic global variance from resting state BOLD-fMRI data; however, recent studies have demonstrated that GSR may introduce spurious negative correlations within and between functional networks, calling into question the meaning of anticorrelations reported between some networks. In the present study, we propose that global signal from resting state fMRI is composed primarily of systemic low frequency oscillations (sLFOs) that propagate with cerebral blood circulation throughout the brain. We introduce a novel systemic noise removal strategy for resting state fMRI data, "dynamic global signal regression" (dGSR), which applies a voxel-specific optimal time delay to the global signal prior to regression from voxel-wise time series. We test our hypothesis on two functional systems that are suggested to be intrinsically organized into anticorrelated networks: the default mode network (DMN) and task positive network (TPN). We evaluate the efficacy of dGSR and compare its performance with the conventional "static" global regression (sGSR) method in terms of (i) explaining systemic variance in the data and (ii) enhancing specificity and sensitivity of functional connectivity measures. dGSR increases the amount of BOLD signal variance being modeled and removed relative to sGSR while reducing spurious negative correlations introduced in reference regions by sGSR, and attenuating inflated positive connectivity measures. We conclude that incorporating time delay information for sLFOs into global noise removal strategies is of crucial importance for optimal noise removal from resting state functional connectivity maps.}, + keywords = {BOLD fMRI +functional connectivity analysis +global signal regression +resting state networks +systemic noise removal +systemic oscillations}, + ISSN = {1662-5161 (Print) +1662-5161 (Linking)}, + DOI = {10.3389/fnhum.2016.00311}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/27445751}, + year = {2016}, + type = {Journal Article} +} + +@article{RN523, + author = {Franceschini, M. A. and Frederick, B. and Renshaw, P. F. and Fantini, S.}, + title = {Mapping the brain cortex with near infrared light: towards simultaneous fMRI and optical imaging of the brain}, + journal = {Neuroimage}, + volume = {13}, + number = {6}, + pages = {S11-S11}, + note = {Franceschini, MA Frederick, B Renshaw, PF Fantini, S +S +Part 2}, + ISSN = {1053-8119}, + url = {://WOS:000169106300012}, + year = {2001}, + type = {Journal Article} +} + +@article{RN3670, + author = {Frederick, B. B. and Satlin, A. and Yurgelun-Todd, D. A. and Renshaw, P. F.}, + title = {In vivo proton magnetic resonance spectroscopy of Alzheimer's disease in the parietal and temporal lobes}, + journal = {Biol Psychiatry}, + volume = {42}, + number = {2}, + pages = {147-50}, + note = {Frederick, B B +Satlin, A +Yurgelun-Todd, D A +Renshaw, P F +eng +Clinical Trial +Randomized Controlled Trial +Research Support, Non-U.S. Gov't +Biol Psychiatry. 1997 Jul 15;42(2):147-50.}, + keywords = {Aged +Aged, 80 and over +Alzheimer Disease/diagnosis/*physiopathology +Aspartic Acid/*analogs & derivatives/metabolism +Brain Mapping +Female +Humans +*Magnetic Resonance Spectroscopy +Male +Mental Status Schedule +Middle Aged +Parietal Lobe/*physiopathology +Reference Values +Temporal Lobe/*physiopathology}, + ISSN = {0006-3223 (Print) +0006-3223 (Linking)}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/9209733}, + year = {1997}, + type = {Journal Article} +} + +@article{RN545, + author = {Frederick, B. D. and Lindsey, K. P. and Nickerson, L. D. and Ryan, E. T. and Lukas, S. E.}, + title = {An MR-compatible device for delivering smoked marijuana during functional imaging}, + journal = {Pharmacology Biochemistry and Behavior}, + volume = {87}, + number = {1}, + pages = {81-89}, + note = {Frederick, Blaise deB. Lindsey, Kimberly P. Nickerson, Lisa D. Ryan, Elizabeth T. Lukas, Scott E.}, + abstract = {Smoking is the preferred method of administration for two of the most frequently abused drugs, marijuana and nicotine. The high temporal and spatial resolution of functional magnetic resonance imaging (fMRI) make it a natural choice for studying the neurobiological effects of smoked drugs if the challenges of smoking in a magnetic resonance (MR) scanner can be overcome. We report on a design for an MR-compatible smoking device that can be used for smoking marijuana (or tobacco) during fMRI examinations. Nine volunteers smoked marijuana cigarettes (3.51% Delta(9)-THC) on two occasions: with and without the device. The device allowed subjects to smoke while they lay in the scanner, while containing all smoke and odors. Plasma Delta(9)-THC, subjective reports of intoxication, and heart rate increases are reported, and were all similar in individuals smoking marijuana either with or without the device. The use of this device will help advance research studies on smoked drugs including marijuana, tobacco and crack cocaine. (c) 2007 Elsevier Inc. All rights reserved.}, + ISSN = {0091-3057}, + DOI = {10.1016/j.pbb.2007.04.006}, + url = {://WOS:000247740300010}, + year = {2007}, + type = {Journal Article} +} + +@article{RN3652, + author = {Frederick, B. D. and Lyoo, I. K. and Satlin, A. and Ahn, K. H. and Kim, M. J. and Yurgelun-Todd, D. A. and Cohen, B. M. and Renshaw, P. F.}, + title = {In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease}, + journal = {Prog Neuropsychopharmacol Biol Psychiatry}, + volume = {28}, + number = {8}, + pages = {1313-22}, + note = {Frederick, Blaise D +Lyoo, In Kyoon +Satlin, Andrew +Ahn, Kyung Heup +Kim, Minue J +Yurgelun-Todd, Deborah A +Cohen, Bruce M +Renshaw, Perry F +eng +Comparative Study +Research Support, Non-U.S. Gov't +England +Prog Neuropsychopharmacol Biol Psychiatry. 2004 Dec;28(8):1313-22. doi: 10.1016/j.pnpbp.2004.08.013.}, + abstract = {PURPOSE: Prior proton magnetic resonance spectroscopy (MRS) studies have consistently reported decreased brain n-acetyl aspartate (NAA) levels and increased myo-inositol (mI) levels in subjects with Alzheimer's disease (AD) relative to healthy comparison subjects. These studies have usually been conducted in small and homogeneous populations of patients with established Alzheimer's disease. Few studies have tested the usefulness of this finding in a general population seeking evaluation for memory loss and other cognitive declines. We designed a study to evaluate the significance of single-voxel proton MRS findings in these patients with memory loss and other cognitive declines. GENERAL METHOD: Thirty-five subjects with a primary complaint of memory loss and other cognitive declines were consecutively referred over a period of 13 months to a specialty clinic. Patients with a diagnosis of mild to moderate probable Alzheimer's disease (N = 22), non-Alzheimer's dementia (depression, multiinfarct dementia, Parkinson's Disease, Korsakoff's Psychosis, and bipolar disorder; N = 13), and healthy comparison subjects (N = 18) were examined with respect to possible differences in metabolites using proton MRS in a 3.4-ml anterior temporal lobe voxel. FINDINGS: The Alzheimer's disease group had 10.7% lower NAA/creatine (Cr) ratios relative to the healthy comparison group and 9.4% lower NAA/creatine relative to the non-Alzheimer's dementia group (15.0% lower NAA/creatine relative to the depression subgroup of the non-Alzheimer's dementia group). There were no significant differences in choline (Cho) or myo-inositol ratios among the groups. There were significant correlations between NAA/creatine ratios and mini-mental status exam (MMSE) scores in subjects with Alzheimer's disease (t = 2.41, p = 0.032) but not in subjects with non-Alzheimer's dementia or in its depression subgroup. CONCLUSIONS: This study found a reduction in the neuronal marker NAA in the anterior temporal lobe of patients diagnosed with probable Alzheimer's disease, using a short add-on proton MRS exam. This change was not observed in patients whose memory loss and other cognitive declines were not attributed to Alzheimer's disease, suggesting that it may aid in the diagnosis or detection of Alzheimer's disease.}, + keywords = {Aged +Aged, 80 and over +Alzheimer Disease/complications/*diagnosis +Analysis of Variance +Aspartic Acid/*analogs & derivatives/metabolism +Brain Mapping +Case-Control Studies +Choline/metabolism +Cognition Disorders/complications/diagnosis +Creatine/metabolism +Dementia/diagnosis/etiology +Female +Humans +Inositol/metabolism +*Magnetic Resonance Spectroscopy +Male +Memory Disorders/diagnosis/etiology +Mental Status Schedule +*Protons +Temporal Lobe/*metabolism/pathology}, + ISSN = {0278-5846 (Print) +0278-5846 (Linking)}, + DOI = {10.1016/j.pnpbp.2004.08.013}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/15588758}, + year = {2004}, + type = {Journal Article} +} + +@article{RN533, + author = {Frederick, B. D. and Lyoo, I. K. and Satlin, A. and Ahn, K. H. and Kim, M. J. and Yurgelun-Todd, D. A. and Cohen, B. M. and Renshaw, P. F.}, + title = {In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease}, + journal = {Progress in Neuro-Psychopharmacology & Biological Psychiatry}, + volume = {28}, + number = {8}, + pages = {1313-1322}, + note = {Frederick, BD Lyoo, IK Satlin, A Ahn, KH Kim, MJ Yurgelun-Todd, DA Cohen, BM Renshaw, PF}, + abstract = {Purpose: Prior proton magnetic resonance spectroscopy (MRS) studies have consistently reported decreased brain n-aceryl aspartate (NAA) levels and increased myo-inositol (ml) levels in subjects with Alzheimer's disease (AD) relative to healthy comparison subjects. These studies have usually been conducted in small and homogeneous populations of patients with established Alzheimer's disease. Few studies have tested the usefulness of this finding in a general population seeking evaluation for memory loss and other cognitive declines. We designed a study to evaluate the significance of single-voxel proton MRS findings in these patients with memory loss and other cognitive declines. General method: Thirty-five subjects with a primary complaint of memory loss and other cognitive declines were consecutively referred over a period of 13 months to a specialty clinic. Patients with a diagnosis of mild to moderate probable Alzheimer's disease (N=22), non-Alzheimer's dementia (depression, multiinfarct dementia, Parkinson's Disease, Korsakoff's Psychosis, and bipolar disorder; N=13), and healthy comparison subjects (N=18) were examined with respect to possible differences in metabolites using proton MRS in a 3.4-ml anterior temporal lobe voxel. Findings: The Alzheimer's disease group had 10.7% lower NAA/creatine (Cr) ratios relative to the healthy comparison group and 9.4% lower NAA/creatine relative to the non-Alzheimer's dementia group (15.0% lower NAA/creatine relative to the depression subgroup of the non-Alzheimer's dementia group). There were no significant differences in choline (Cho) or myo-inositol ratios among the groups. There were significant correlations between NAA/creatine ratios and mini-mental status exam (MMSE) scores in subjects with Alzheimer's disease (t=2.41, p=0.032) but not in subjects with non-Alzheimer's dementia or in its depression subgroup. Conclusions: This study found a reduction in the neuronal marker NAA in the anterior temporal lobe of patients diagnosed with probable Alzheimer's disease, using a short add-on proton MRS exam. This change was not observed in patients whose memory loss and other cognitive declines were not attributed to Alzheimer's disease, suggesting that it may aid in the diagnosis or detection of Alzheimer's disease. (C) 2004 Elsevier Inc. All rights reserved.}, + ISSN = {0278-5846}, + DOI = {10.1016/j.pnpbp.2004.08.013}, + url = {://WOS:000225907000011}, + year = {2004}, + type = {Journal Article} +} + +@article{RN505, + author = {Frederick, B. D. and Nickerson, L. D. and Tong, Y. J.}, + title = {Physiological denoising of BOLD fMRI data using Regressor Interpolation at Progressive Time Delays (RIPTiDe) processing of concurrent fMRI and near-infrared spectroscopy (NIRS)}, + journal = {Neuroimage}, + volume = {60}, + number = {3}, + pages = {1913-1923}, + note = {Frederick, Blaise deB. Nickerson, Lisa D. Tong, Yunjie}, + abstract = {Confounding noise in BOLD fMRI data arises primarily from fluctuations in blood flow and oxygenation due to cardiac and respiratory effects, spontaneous low frequency oscillations (LFO) in arterial pressure. and non-task related neural activity. Cardiac noise is particularly problematic, as the low sampling frequency of BOLD fMRI ensures that these effects are aliased in recorded data. Various methods have been proposed to estimate the noise signal through measurement and transformation of the cardiac and respiratory waveforms (e.g. RETROICOR and respiration volume per time (RVT)) and model-free estimation of noise variance through examination of spatial and temporal patterns. We have previously demonstrated that by applying a voxel-specific time delay to concurrently acquired near infrared spectroscopy (NIRS) data, we can generate regressors that reflect systemic blood flow and oxygenation fluctuations effects. Here, we apply this method to the task of removing physiological noise from BOLD data. We compare the efficacy of noise removal using various sets of noise regressors generated from NIRS data, and also compare the noise removal to RETROICOR+RVT. We compare the results of resting state analyses using the original and noise filtered data, and we evaluate the bias for the different noise filtration methods by computing null distributions from the resting data and comparing them with the expected theoretical distributions. Using the best set of processing choices, six NIRS-generated regressors with voxel-specific time delays explain a median of 10.5% of the variance throughout the brain, with the highest reductions being seen in gray matter. By comparison, the nine RETROICOR+RVT regressors together explain a median of 6.8% of the variance in the BOLD data. Detection of resting state networks was enhanced with NIRS denoising, and there were no appreciable differences in the bias of the different techniques. Physiological noise regressors generated using Regressor Interpolation at Progressive Time Delays (RIPTiDe) offer an effective method for efficiently removing hemodynamic noise from BOLD data. (C) 2012 Elsevier Inc. All rights reserved.}, + ISSN = {1053-8119}, + DOI = {10.1016/j.neuroimage.2012.01.140}, + url = {://WOS:000302202800031}, + year = {2012}, + type = {Journal Article} +} + +@article{RN520, + author = {Frederick, B. D. and Satlin, A. and Wald, L. L. and Hennen, J. and Bodick, N. and Renshaw, P. F.}, + title = {Brain proton magnetic resonance spectroscopy in Alzheimer disease - Changes after treatment with xanomeline}, + journal = {American Journal of Geriatric Psychiatry}, + volume = {10}, + number = {1}, + pages = {81-88}, + note = {Frederick, BD Satlin, A Wald, LL Hennen, J Bodick, N Renshaw, PF +6th Annual Meeting of the International-Society-for-Magnetic-Resonance-in-Medicine +APR 17-25, 1998 +SYDNEY, AUSTRALIA +Int Soc Magnet Resonance Med}, + abstract = {Patients with mild-to-moderate Alzheimer disease received transdermal xanomeline an M-1-selective cholinergic agonist, or placebo for 4 months. Clinical assessments and proton magnetic resonance spectroscopic imaging examinations were carried out at baseline, and after 8 and 16 weeks of treatment, There was a positive correlation between change from baseline in parietal lobe gray-matter cytosolic choline, expressed in terms of choline/creatine resonance ratios, and cognitive performance as measured with the Alzheimer's Disease Assessment Scale Cognitive Subscale. Specifically increased levels of cytosolic choline, a precursor pool for acetylcholine synthesis, were associated with greater progression in memory impairment during treatment.}, + ISSN = {1064-7481}, + DOI = {10.1176/appi.ajgp.10.1.81}, + url = {://WOS:000173224900010}, + year = {2002}, + type = {Journal Article} +} + +@article{RN513, + author = {Frederick, B. D. and Satlin, A. and YurgelunTodd, D. A. and Renshaw, P. F.}, + title = {In vivo proton magnetic resonance spectroscopy of Alzheimer's disease in the parietal and temporal lobes}, + journal = {Biological Psychiatry}, + volume = {42}, + number = {2}, + pages = {147-150}, + note = {Frederick, BD Satlin, A YurgelunTodd, DA Renshaw, PF}, + ISSN = {0006-3223}, + url = {://WOS:A1997XG23800011}, + year = {1997}, + type = {Journal Article} +} + +@article{RN517, + author = {Frederick, B. D. and Satlin, A. and YurgelunTodd, D. and Renshaw, P. F.}, + title = {In vivo proton MRS of Alzheimer's disease in the parietal and temporal lobes}, + journal = {Biological Psychiatry}, + volume = {39}, + number = {7}, + pages = {538-538}, + note = {Frederick, BD Satlin, A YurgelunTodd, D Renshaw, PF}, + ISSN = {0006-3223}, + url = {://WOS:A1996UE89300523}, + year = {1996}, + type = {Journal Article} +} + +@article{RN528, + author = {Frederick, B. D. and Wald, L. L. and Maas, L. C. and Renshaw, P. F.}, + title = {A phased array echoplanar imaging system for fMRI}, + journal = {Magnetic Resonance Imaging}, + volume = {17}, + number = {1}, + pages = {121-129}, + note = {Frederick, BD Wald, LL Maas, LC Renshaw, PF}, + abstract = {A fully parallel, simultaneous sampling phased array receiver system for a clinical echoplanar imaging system is described and evaluated for BOLD activation and relative cerebral blood volume (rCBV) experiments. A 4-coil array curved around the occipital lobe improved SNR by factors of 1.5 in the visual cortex and 3.1 in the visual association cortex relative to a 13-cm diameter surface coil, improving the statistical significance and coverage of visual activation maps. A I-coil bilateral array increased SNR throughout the head relative to a quadrature head coil by up to a factor of 5 in much of the cortex, with proportional improvement in the SNR of rCBV maps. (C) 1998 Elsevier Science Inc.}, + ISSN = {0730-725X}, + DOI = {10.1016/s0730-725x(98)00157-x}, + url = {://WOS:000077953600013}, + year = {1999}, + type = {Journal Article} +} + +@article{RN3664, + author = {Frederick, Bd and Lindsey, K. P. and Nickerson, L. D. and Ryan, E. T. and Lukas, S. E.}, + title = {An MR-compatible device for delivering smoked marijuana during functional imaging}, + journal = {Pharmacol Biochem Behav}, + volume = {87}, + number = {1}, + pages = {81-9}, + note = {Frederick, Blaise deB +Lindsey, Kimberly P +Nickerson, Lisa D +Ryan, Elizabeth T +Lukas, Scott E +eng +K05 DA000343-10/DA/NIDA NIH HHS/ +R01 DA003994-19S1/DA/NIDA NIH HHS/ +DA019238/DA/NIDA NIH HHS/ +DA14013/DA/NIDA NIH HHS/ +K25 DA014013/DA/NIDA NIH HHS/ +DA017712/DA/NIDA NIH HHS/ +R01 DA019238-02/DA/NIDA NIH HHS/ +K25 DA017712/DA/NIDA NIH HHS/ +DA03994/DA/NIDA NIH HHS/ +DA00343/DA/NIDA NIH HHS/ +K25 DA014013-05/DA/NIDA NIH HHS/ +R01 DA003994/DA/NIDA NIH HHS/ +K05 DA000343/DA/NIDA NIH HHS/ +K25 DA017712-02/DA/NIDA NIH HHS/ +R01 DA019238/DA/NIDA NIH HHS/ +K25 DA014013-04/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Pharmacol Biochem Behav. 2007 May;87(1):81-9. doi: 10.1016/j.pbb.2007.04.006. Epub 2007 Apr 13.}, + abstract = {Smoking is the preferred method of administration for two of the most frequently abused drugs, marijuana and nicotine. The high temporal and spatial resolution of functional magnetic resonance imaging (fMRI) make it a natural choice for studying the neurobiological effects of smoked drugs if the challenges of smoking in a magnetic resonance (MR) scanner can be overcome. We report on a design for an MR-compatible smoking device that can be used for smoking marijuana (or tobacco) during fMRI examinations. Nine volunteers smoked marijuana cigarettes (3.51% Delta9-THC) on two occasions: with and without the device. The device allowed subjects to smoke while they lay in the scanner, while containing all smoke and odors. Plasma Delta9-THC, subjective reports of intoxication, and heart rate increases are reported, and were all similar in individuals smoking marijuana either with or without the device. The use of this device will help advance research studies on smoked drugs including marijuana, tobacco and crack cocaine.}, + keywords = {Affect/drug effects +Brain/drug effects/physiology +Dronabinol/administration & dosage/analysis +Heart Rate/drug effects +Humans +Magnetic Resonance Imaging/*instrumentation +Marijuana Smoking/*physiopathology/psychology +Noise +Oxygen/blood +Reproducibility of Results +Smoke}, + ISSN = {0091-3057 (Print) +0091-3057 (Linking)}, + DOI = {10.1016/j.pbb.2007.04.006}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/17521714}, + year = {2007}, + type = {Journal Article} +} + +@article{RN2374, + author = {Frederick, Bd and Nickerson, L. D. and Tong, Y.}, + title = {Physiological denoising of BOLD fMRI data using Regressor Interpolation at Progressive Time Delays (RIPTiDe) processing of concurrent fMRI and near-infrared spectroscopy (NIRS)}, + journal = {Neuroimage}, + volume = {60}, + number = {3}, + pages = {1913-23}, + note = {Frederick, Blaise deB +Nickerson, Lisa D +Tong, Yunjie +eng +R21 DA021817/DA/NIDA NIH HHS/ +R21 DA021817-02/DA/NIDA NIH HHS/ +R21 DA027877-02/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +R21-DA021817/DA/NIDA NIH HHS/ +R21-DA027877/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Neuroimage. 2012 Apr 15;60(3):1913-23. doi: 10.1016/j.neuroimage.2012.01.140. Epub 2012 Feb 9.}, + abstract = {Confounding noise in BOLD fMRI data arises primarily from fluctuations in blood flow and oxygenation due to cardiac and respiratory effects, spontaneous low frequency oscillations (LFO) in arterial pressure, and non-task related neural activity. Cardiac noise is particularly problematic, as the low sampling frequency of BOLD fMRI ensures that these effects are aliased in recorded data. Various methods have been proposed to estimate the noise signal through measurement and transformation of the cardiac and respiratory waveforms (e.g. RETROICOR and respiration volume per time (RVT)) and model-free estimation of noise variance through examination of spatial and temporal patterns. We have previously demonstrated that by applying a voxel-specific time delay to concurrently acquired near infrared spectroscopy (NIRS) data, we can generate regressors that reflect systemic blood flow and oxygenation fluctuations effects. Here, we apply this method to the task of removing physiological noise from BOLD data. We compare the efficacy of noise removal using various sets of noise regressors generated from NIRS data, and also compare the noise removal to RETROICOR+RVT. We compare the results of resting state analyses using the original and noise filtered data, and we evaluate the bias for the different noise filtration methods by computing null distributions from the resting data and comparing them with the expected theoretical distributions. Using the best set of processing choices, six NIRS-generated regressors with voxel-specific time delays explain a median of 10.5% of the variance throughout the brain, with the highest reductions being seen in gray matter. By comparison, the nine RETROICOR+RVT regressors together explain a median of 6.8% of the variance in the BOLD data. Detection of resting state networks was enhanced with NIRS denoising, and there were no appreciable differences in the bias of the different techniques. Physiological noise regressors generated using Regressor Interpolation at Progressive Time Delays (RIPTiDe) offer an effective method for efficiently removing hemodynamic noise from BOLD data.}, + keywords = {Adult +Algorithms +*Artifacts +Brain/*physiology +Female +Functional Neuroimaging/*methods +Humans +Image Enhancement/methods +Image Interpretation, Computer-Assisted/*methods +Magnetic Resonance Imaging/*methods +Male +Oxygen Consumption/*physiology +Regression Analysis +Reproducibility of Results +Sensitivity and Specificity +Signal-To-Noise Ratio +Spectroscopy, Near-Infrared/*methods}, + ISSN = {1095-9572 (Electronic) +1053-8119 (Linking)}, + DOI = {10.1016/j.neuroimage.2012.01.140}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/22342801}, + year = {2012}, + type = {Journal Article} +} + +@article{RN503, + author = {Friedman, S. D. and Jensen, J. E. and Frederick, B. B. and Artru, A. A. and Renshaw, P. F. and Dager, S. R.}, + title = {Brain changes to hypocapnia using rapidly interleaved phosphorus-proton magnetic resonance spectroscopy at 4 T}, + journal = {J Cereb Blood Flow Metab}, + volume = {27}, + number = {3}, + pages = {646-53}, + note = {Friedman, Seth D +Jensen, J Eric +Frederick, Blaise B +Artru, Alan A +Renshaw, Perry F +Dager, Stephen R +eng +K01 MH069848/MH/NIMH NIH HHS/ +K25 DA14013/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +J Cereb Blood Flow Metab. 2007 Mar;27(3):646-53. doi: 10.1038/sj.jcbfm.9600383. Epub 2006 Aug 9.}, + abstract = {Substantial controversy persists in the literature concerning the physiologic consequences hypocapnia, or low partial pressure of carbon dioxide (PaCO(2)). Invasive animal studies have demonstrated large pH increases (>0.25 U), phosphocreatine (PCr) decreases (>30%), and adenosine triphosphate (ATP) decreases (>10%) after hyperventilation (HV) (20 mm Hg PaCO(2)). However, using magnetic resonance spectroscopy, HV studies in awake humans have demonstrated only small pH changes ( approximately 0.05 U) and no changes in PCr or ATP. It remains important to ascertain whether this failure to detect PCr changes in human studies reflects a true absence of changes, or a limitation in data fidelity. The present study used a rapidly interleaved phosphorus-proton spectroscopy acquisition from large samples at high magnetic field (4 T), to measure pH, PCr, inorganic phosphate, beta-ATP, and lactate changes with high temporal and signal sensitivity. Five of six subjects had usable data. During 20 mins HV, PaCO(2) reached a minimum at 16 mins (17 mm Hg); however, the maximum pH change (+0.047) peaked earlier (14 mins). Maximal lactate increases were measured at 15 mins. By 10 mins, maximum changes were observed for PCr (-3.4%) and inorganic phosphate (+6.4%). No changes in beta-ATP were observed. The peak in pH, despite continued decreases in PaCO(2), suggests active buffering during HV. These data, and the small magnitude of early PCr and inorganic phosphate changes, do not support substantial energy compromise during HV. Other mitigating factors, such as anesthesia-induced deregulation of the cerebrovasculature, might have contributed to the exaggerated metabolic changes observed in previous animal investigations.}, + keywords = {Adenosine Triphosphate/metabolism +Adult +Brain/*metabolism +Female +Humans +Hydrogen-Ion Concentration +Hyperventilation/complications +Hypocapnia/etiology/*physiopathology +Lactic Acid/metabolism +*Magnetic Resonance Spectroscopy +Male +Phosphates/metabolism +Phosphocreatine/metabolism +Phosphorus +Protons}, + ISSN = {0271-678X (Print) +0271-678X (Linking)}, + DOI = {10.1038/sj.jcbfm.9600383}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16896347}, + year = {2007}, + type = {Journal Article} +} + +@article{RN547, + author = {Friedman, S. D. and Jensen, J. E. and Frederick, B. B. and Artru, A. A. and Renshaw, P. F. and Dager, S. R.}, + title = {Brain changes to hypocapnia using rapidly interleaved phosphorus-proton magnetic resonance spectroscopy at 4 T}, + journal = {Journal of Cerebral Blood Flow and Metabolism}, + volume = {27}, + number = {3}, + pages = {646-653}, + note = {Friedman, Seth D. Jensen, J. Eric Frederick, Blaise B. Artru, Alan A. Renshaw, Perry F. Dager, Stephen R.}, + abstract = {Substantial controversy persists in the literature concerning the physiologic consequences hypocapnia, or low partial pressure of carbon dioxide ( PaCO2). Invasive animal studies have demonstrated large pH increases ( > 0.25 U), phosphocreatine ( PCr) decreases ( > 30%), and adenosine triphosphate ( ATP) decreases ( > 10%) after hyperventilation ( HV) ( 20mm Hg PaCO2). However, using magnetic resonance spectroscopy, HV studies in awake humans have demonstrated only small pH changes ( similar to 0.05U) and no changes in PCr or ATP. It remains important to ascertain whether this failure to detect PCr changes in human studies reflects a true absence of changes, or a limitation in data fidelity. The present study used a rapidly interleaved phosphorus- proton spectroscopy acquisition from large samples at high magnetic field ( 4 T), to measure pH, PCr, inorganic phosphate, beta-ATP, and lactate changes with high temporal and signal sensitivity. Five of six subjects had usable data. During 20 mins HV, PaCO2 reached a minimum at 16 mins ( 17mm Hg); however, the maximum pH change ( + 0.047) peaked earlier ( 14 mins). Maximal lactate increases were measured at 15 mins. By 10 mins, maximum changes were observed for PCr ( -3.4%) and inorganic phosphate ( + 6.4%). No changes in beta-ATP were observed. The peak in pH, despite continued decreases in PaCO2, suggests active buffering during HV. These data, and the small magnitude of early PCr and inorganic phosphate changes, do not support substantial energy compromise during HV. Other mitigating factors, such as anesthesia- induced deregulation of the cerebrovasculature, might have contributed to the exaggerated metabolic changes observed in previous animal investigations.}, + ISSN = {0271-678X}, + DOI = {10.1038/sj.jcbfm.9600383}, + url = {://WOS:000244387100020}, + year = {2007}, + type = {Journal Article} +} + +@article{RN2816, + author = {Hocke, L M and Oni, I K and Duszynski, C C and Corrigan, A V and Frederick, B B and Dunn, J F}, + title = {Algorithms for Functional Near-Infrared Spectroscopy, Cerebral Oximetry and Near-Infrared Imaging}, + journal = {Algorithms}, + volume = {In revision}, + year = {2018}, + type = {Journal Article} +} + +@article{RN2790, + author = {Hocke, L. M. and Cayetano, K. and Tong, Y. and Frederick, B.}, + title = {Optimized multimodal functional magnetic resonance imaging/near-infrared spectroscopy probe for ultrahigh-resolution mapping}, + journal = {Neurophotonics}, + volume = {2}, + number = {4}, + pages = {045004}, + note = {Hocke, Lia Maria +Cayetano, Kenroy +Tong, Yunjie +Frederick, Blaise +eng +K25 DA031769/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +Neurophotonics. 2015 Oct;2(4):045004. doi: 10.1117/1.NPh.2.4.045004. Epub 2015 Dec 10.}, + abstract = {Functional near-infrared spectroscopy (fNIRS) is an increasingly important noninvasive method in neuroscience due to its high temporal resolution and ability to independently measure oxy- and deoxy-hemoglobin. However, the relatively low spatial resolution of fNIRS makes it difficult to relate this signal to underlying anatomy. Simultaneous functional magnetic resonance imaging (fMRI) can complement fNIRS with superior spatial resolution and the ability to image the entire brain, providing additional information to improve fNIRS localization. However, current simultaneous fMRI/fNIRS acquisition methods are not optimal, due to the poor physical compatibility of existing MR coils and fNIRS optodes. Here, we present a technique to manufacture a true multimodal fMRI/fNIRS probe in which both modalities can be used with maximal sensitivity. To achieve this, we designed custom MR coils with integral fNIRS optodes using three-dimensional printing. This multimodal probe can be used to optimize spatial ([Formula: see text]) and temporal resolution (2.5 Hz) of fMRI, and it provides maximal MRI sensitivity, while allowing for high flexibility in the location and density of fNIRS optodes within the area of interest. Phantom and human data are shown to confirm the improvement in sensitivity in both modalities. This probe shows promise for addressing fundamental questions of the relation of fNIRS to physiology.}, + keywords = {functional magnetic resonance imaging +functional near-infrared spectroscopy +optics +simultaneous measurements +ultra-high spatial resolution +ultra-high temporal resolution}, + ISSN = {2329-423X (Print) +2329-423X (Linking)}, + DOI = {10.1117/1.NPh.2.4.045004}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/26668816}, + year = {2015}, + type = {Journal Article} +} + +@article{RN3628, + author = {Hocke, L. M. and Tong, Y. and Lindsey, K. P. and de, B. Frederick B.}, + title = {Comparison of peripheral near-infrared spectroscopy low-frequency oscillations to other denoising methods in resting state functional MRI with ultrahigh temporal resolution}, + journal = {Magn Reson Med}, + volume = {76}, + number = {6}, + pages = {1697-1707}, + note = {Hocke, Lia M +Tong, Yunjie +Lindsey, Kimberly P +de B Frederick, Blaise +eng +K25 DA031769/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +Comparative Study +Evaluation Studies +Research Support, N.I.H., Extramural +Magn Reson Med. 2016 Dec;76(6):1697-1707. doi: 10.1002/mrm.26038. Epub 2016 Feb 7.}, + abstract = {PURPOSE: Functional MRI (fMRI) blood-oxygen level-dependent (BOLD) signals result not only from neuronal activation, but also from nonneuronal physiological processes. These changes, especially in the low-frequency domain (0.01-0.2 Hz), can significantly confound inferences about neuronal processes. It is crucial to effectively identify these nuisance low-frequency oscillations (LFOs). METHOD: A high temporal resolution (repetition time, approximately 0.5 s) fMRI resting state study was conducted with simultaneous physiological measurements to compare LFOs measured directly by near-infrared spectroscopy (NIRS) in the periphery and three methods that model LFOs from the respiration or cardiac signal: 1) the respiration volume per time (RVT), 2) the respiratory variation (RVRRF), and 3) the cardiac variation method (HRCRF). The LFO noise regressors from these methods were compared temporally and spatially as well as in their denoising efficiency. RESULTS: Methods were not highly correlated with one another, temporally or spatially. The set of two NIRS LFOs combined explained over 13% of BOLD signal variance and explained equal or more variance than HRCRF and RVRRF or RVT combined (in 14 of 16 participants). CONCLUSION: LFOs collected using NIRS in the periphery contain distinct temporal and spatial information about the LFOs in BOLD fMRI that is not contained in current low-frequency denoising methods derived from respiration and cardiac pulsation. Magn Reson Med 76:1697-1707, 2016. (c) 2016 International Society for Magnetic Resonance in Medicine.}, + keywords = {Adult +Algorithms +Brain/anatomy & histology/*physiology +Female +Humans +Image Enhancement/*methods +Image Interpretation, Computer-Assisted/*methods +Magnetic Resonance Imaging/*methods +Male +Oscillometry/*methods +Reproducibility of Results +Sensitivity and Specificity +Signal-To-Noise Ratio +Spectrophotometry, Infrared/*methods +*BOLD fMRI denoising +*nirs +*cardiac +*low-frequency oscillations +*multiband +*respiration}, + ISSN = {1522-2594 (Electronic) +0740-3194 (Linking)}, + DOI = {10.1002/mrm.26038}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/26854203}, + year = {2016}, + type = {Journal Article} +} + +@article{RN2493, + author = {Hocke, LM and Cayetano, KC and Tong, Y and Frederick, BB}, + title = {An optimized multimodal fMRI/NIRS probe for ultra-high resolution mapping}, + journal = {Neurophotonics}, + volume = {In Press}, + year = {2015}, + type = {Journal Article} +} + +@article{RN571, + author = {Janes, A. C. and Farmer, S. and Frederick, Bd and Nickerson, L. D. and Lukas, S. E.}, + title = {An increase in tobacco craving is associated with enhanced medial prefrontal cortex network coupling}, + journal = {PLoS One}, + volume = {9}, + number = {2}, + pages = {e88228}, + note = {Janes, Amy C +Farmer, Stacey +Frederick, Blaise deB +Nickerson, Lisa D +Lukas, Scott E +eng +K01 DA029645/DA/NIDA NIH HHS/ +K01DA029645/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +PLoS One. 2014 Feb 5;9(2):e88228. doi: 10.1371/journal.pone.0088228. eCollection 2014.}, + abstract = {Craving is a key aspect of drug dependence that is thought to motivate continued drug use. Numerous brain regions have been associated with craving, suggesting that craving is mediated by a distributed brain network. Whether an increase in subjective craving is associated with enhanced interactions among brain regions was evaluated using resting state functional magnetic imaging (fMRI) in nicotine dependent participants. We focused on craving-related changes in the orbital and medial prefrontal cortex (OMPFC) network, which also included the subgenual anterior cingulate cortex (sgACC) extending into the ventral striatum. Brain regions in the OMPFC network are not only implicated in addiction and reward, but, due to their rich anatomic interconnections, may serve as the site of integration across craving-related brain regions. Subjective craving and resting state fMRI were evaluated twice with an approximately 1 hour delay between the scans. Cigarette craving was significantly increased at the end, relative to the beginning of the scan session. Enhanced craving was associated with heightened coupling between the OMPFC network and other cortical, limbic, striatal, and visceromotor brain regions that are both anatomically interconnected with the OMPFC, and have been implicated in addiction and craving. This is the first demonstration confirming that an increase in craving is associated with enhanced brain region interactions, which may play a role in the experience of craving.}, + keywords = {Adult +Brain Mapping +Female +Humans +Magnetic Resonance Imaging +Male +Prefrontal Cortex/*physiopathology +Tobacco/adverse effects +Tobacco Use Disorder/*physiopathology +Young Adult}, + ISSN = {1932-6203 (Electronic) +1932-6203 (Linking)}, + DOI = {10.1371/journal.pone.0088228}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/24505440}, + year = {2014}, + type = {Journal Article} +} + +@article{RN3631, + author = {Janes, A. C. and Farmer, S. and Peechatka, A. L. and Frederick Bde, B. and Lukas, S. E.}, + title = {Insula-Dorsal Anterior Cingulate Cortex Coupling is Associated with Enhanced Brain Reactivity to Smoking Cues}, + journal = {Neuropsychopharmacology}, + volume = {40}, + number = {7}, + pages = {1561-8}, + note = {Janes, Amy C +Farmer, Stacey +Peechatka, Alyssa L +Frederick, Blaise de B +Lukas, Scott E +eng +K01 DA029645/DA/NIDA NIH HHS/ +K01DA029645/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +England +Neuropsychopharmacology. 2015 Jun;40(7):1561-8. doi: 10.1038/npp.2015.9. Epub 2015 Jan 8.}, + abstract = {The insula plays a critical role in maintaining nicotine dependence and reactivity to smoking cues. More broadly, the insula and the dorsal anterior cingulate cortex (dACC) are key nodes of the salience network (SN), which integrates internal and extrapersonal information to guide behavior. Thus, insula-dACC interactions may be integral in processing salient information such as smoking cues that facilitate continued nicotine use. We evaluated functional magnetic resonance imaging (fMRI) data from nicotine-dependent participants during rest, and again when they viewed smoking-related images. Greater insula-dACC coupling at rest was significantly correlated with enhanced smoking cue-reactivity in brain areas associated with attention and motor preparation, including the visual cortex, right ventral lateral prefrontal cortex, and the dorsal striatum. In an independent cohort, we found that insula-dACC connectivity was stable over 1-h delay and was not influenced by changes in subjective craving or expired carbon monoxide, suggesting that connectivity strength between these regions may be a trait associated with heightened cue-reactivity. Finally, we also showed that insula reactivity to smoking cues correlates with a rise in cue-reactivity throughout the entire SN, indicating that the insula's role in smoking cue-reactivity is not functionally independent, and may actually represent the engagement of the entire SN. Collectively, these data provide a more network-level understanding of the insula's role in nicotine dependence and shows a relationship between inherent brain organization and smoking cue-reactivity.}, + keywords = {Adult +Brain Mapping +Cerebral Cortex/blood supply/*physiology +*Cues +Female +Gyrus Cinguli/blood supply/*physiology +Humans +Image Processing, Computer-Assisted +Magnetic Resonance Imaging +Male +Neural Pathways/blood supply/*physiology +Oxygen/blood +Photic Stimulation +Smoking/*pathology +Surveys and Questionnaires +Young Adult}, + ISSN = {1740-634X (Electronic) +0893-133X (Linking)}, + DOI = {10.1038/npp.2015.9}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/25567427}, + year = {2015}, + type = {Journal Article} +} + +@article{RN3660, + author = {Janes, A. C. and Frederick, Bd and Richardt, S. and Burbridge, C. and Merlo-Pich, E. and Renshaw, P. F. and Evins, A. E. and Fava, M. and Kaufman, M. J.}, + title = {Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence}, + journal = {Exp Clin Psychopharmacol}, + volume = {17}, + number = {6}, + pages = {365-73}, + note = {Janes, Amy C +Frederick, Blaise deB +Richardt, Sarah +Burbridge, Caitlin +Merlo-Pich, Emilio +Renshaw, Perry F +Evins, A Eden +Fava, Maurizio +Kaufman, Marc J +eng +R01DA014674/DA/NIDA NIH HHS/ +R01 DA009448/DA/NIDA NIH HHS/ +K02DA017324/DA/NIDA NIH HHS/ +K02 DA017324/DA/NIDA NIH HHS/ +R01 DA014674/DA/NIDA NIH HHS/ +T32DA015036/DA/NIDA NIH HHS/ +K24 DA015116/DA/NIDA NIH HHS/ +R01DA09448/DA/NIDA NIH HHS/ +K24DA015116/DA/NIDA NIH HHS/ +U01 DA019378/DA/NIDA NIH HHS/ +R01DA022276/DA/NIDA NIH HHS/ +R01 DA022276/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +U01DA019378/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +Research Support, U.S. Gov't, Non-P.H.S. +Exp Clin Psychopharmacol. 2009 Dec;17(6):365-73. doi: 10.1037/a0017797.}, + abstract = {Reactivity to smoking-related cues may play a role in the maintenance of smoking behavior and may change depending on smoking status. Whether smoking cue-related functional MRI (fMRI) reactivity differs between active smoking and extended smoking abstinence states currently is unknown. We used fMRI to measure brain reactivity in response to smoking-related versus neutral images in 13 tobacco-dependent subjects before a smoking cessation attempt and again during extended smoking abstinence (52 +/- 11 days) aided by nicotine replacement therapy. Prequit smoking cue induced fMRI activity patterns paralleled those reported in prior smoking cue reactivity fMRI studies. Greater fMRI activity was detected during extended smoking abstinence than during the pre-quit [corrected] assessment subcortically in the caudate nucleus and cortically in prefrontal (BA 6, 8, 9, 10, 44, 46), [corrected] primary somatosensory (BA 1, 2, 3), temporal (BA 22), [corrected] parietal (BA 5, 7, 40), occipital (BA 17, 18), [corrected] and posterior cingulate (BA 31) cortex. These data suggest that during extended smoking abstinence, fMRI reactivity to smoking versus neutral stimuli persists in brain areas involved in attention, somatosensory processing, motor planning, and conditioned cue responding. In some brain regions, fMRI smoking cue reactivity is increased during extended smoking abstinence in comparison to the prequit state, which may contribute to persisting relapse vulnerability.}, + keywords = {Adult +Brain/*blood supply/pathology +*Brain Mapping +Female +Humans +Image Processing, Computer-Assisted/methods +*Magnetic Resonance Imaging +Middle Aged +Oxygen/blood +Psychological Tests +Smoking/*pathology/psychology +*Smoking Cessation/psychology}, + ISSN = {1936-2293 (Electronic) +1064-1297 (Linking)}, + DOI = {10.1037/a0017797}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/19968401}, + year = {2009}, + type = {Journal Article} +} + +@article{RN565, + author = {Janes, A. C. and Jensen, J. E. and Farmer, S. L. and Frederick, B. D. and Pizzagalli, D. A. and Lukas, S. E.}, + title = {GABA Levels in The Dorsal Anterior Cingulate Cortex Associated with Difficulty Ignoring Smoking-Related Cues in Tobacco-Dependent Volunteers}, + journal = {Neuropsychopharmacology}, + volume = {38}, + number = {6}, + pages = {1113-20}, + abstract = {Substance abusers have difficulty ignoring drug-related cues, which is associated with relapse vulnerability. This 'attentional bias' towards drug cues translates into an inability to ignore drug-related stimuli and may reflect deficits in the brain regions, such as the dorsal anterior cingulate cortex (dACC)-a key region in cognitive control and adaptive decision making. Quantifying relationships between attentional biases to drug cues and dACC neurochemistry could aid in identifying neurobiological mechanisms associated with increased relapse vulnerability precipitated by drug cues. As gamma-aminobutyric acid (GABA) deficits have been linked to impaired cognition and addictive disorders, we hypothesized that reduced GABA in the dACC would be associated with increased attentional biases towards smoking-related cues. We confirmed this hypothesis among nicotine-dependent tobacco smokers by combining an offline behavioral measure of attentional bias with magnetic resonance spectroscopy. Smokers with the greatest attentional bias also experienced more negative affect during early nicotine withdrawal. Findings revealed a relationship between heightened reactivity to drug cues, and both decreasing dACC GABA and early withdrawal symptoms. Because reduced GABA function in frontal brain regions disrupt cognitive function, our findings suggest that smokers with diminished dACC GABA may lack the cognitive resources to successfully ignore highly salient distractors such as tobacco-related stimuli and therefore might be more prone to cue-induced relapse. This newly discovered relationship between dACC GABA and attentional bias provides evidence for a neurochemical target, which may aid smoking cessation in highly cue-reactive individuals.}, + ISSN = {1740-634X}, + DOI = {10.1038/npp.2013.10}, + url = {http://www.ncbi.nlm.nih.gov/pubmed/23306182}, + year = {2013}, + type = {Journal Article} +} + +@article{RN3642, + author = {Janes, A. C. and Jensen, J. E. and Farmer, S. L. and Frederick, B. D. and Pizzagalli, D. A. and Lukas, S. E.}, + title = {GABA levels in the dorsal anterior cingulate cortex associated with difficulty ignoring smoking-related cues in tobacco-dependent volunteers}, + journal = {Neuropsychopharmacology}, + volume = {38}, + number = {6}, + pages = {1113-20}, + note = {Janes, Amy C +Jensen, John Eric +Farmer, Stacey L +Frederick, Blaise Deb +Pizzagalli, Diego A +Lukas, Scott E +eng +K01 DA029645/DA/NIDA NIH HHS/ +K01DA029645/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +England +Neuropsychopharmacology. 2013 May;38(6):1113-20. doi: 10.1038/npp.2013.10. Epub 2013 Jan 10.}, + abstract = {Substance abusers have difficulty ignoring drug-related cues, which is associated with relapse vulnerability. This 'attentional bias' towards drug cues translates into an inability to ignore drug-related stimuli and may reflect deficits in the brain regions, such as the dorsal anterior cingulate cortex (dACC)-a key region in cognitive control and adaptive decision making. Quantifying relationships between attentional biases to drug cues and dACC neurochemistry could aid in identifying neurobiological mechanisms associated with increased relapse vulnerability precipitated by drug cues. As gamma-aminobutyric acid (GABA) deficits have been linked to impaired cognition and addictive disorders, we hypothesized that reduced GABA in the dACC would be associated with increased attentional biases towards smoking-related cues. We confirmed this hypothesis among nicotine-dependent tobacco smokers by combining an offline behavioral measure of attentional bias with magnetic resonance spectroscopy. Smokers with the greatest attentional bias also experienced more negative affect during early nicotine withdrawal. Findings revealed a relationship between heightened reactivity to drug cues, and both decreasing dACC GABA and early withdrawal symptoms. Because reduced GABA function in frontal brain regions disrupt cognitive function, our findings suggest that smokers with diminished dACC GABA may lack the cognitive resources to successfully ignore highly salient distractors such as tobacco-related stimuli and therefore might be more prone to cue-induced relapse. This newly discovered relationship between dACC GABA and attentional bias provides evidence for a neurochemical target, which may aid smoking cessation in highly cue-reactive individuals.}, + keywords = {Adolescent +Adult +Attention/*physiology +*Cues +Female +Gyrus Cinguli/*metabolism +Humans +Male +Photic Stimulation/methods +Psychomotor Performance/physiology +Reaction Time/physiology +Smoking/*metabolism/psychology +Tobacco Use Disorder/*metabolism/psychology +Young Adult +gamma-Aminobutyric Acid/*metabolism}, + ISSN = {1740-634X (Electronic) +0893-133X (Linking)}, + DOI = {10.1038/npp.2013.10}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/23306182}, + year = {2013}, + type = {Journal Article} +} + +@article{RN3647, + author = {Janes, A. C. and Nickerson, L. D. and Frederick Bde, B. and Kaufman, M. J.}, + title = {Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls}, + journal = {Drug Alcohol Depend}, + volume = {125}, + number = {3}, + pages = {252-9}, + note = {Janes, Amy C +Nickerson, Lisa D +Frederick, Blaise De B +Kaufman, Marc J +eng +K01 DA029645/DA/NIDA NIH HHS/ +T32DA015036/DA/NIDA NIH HHS/ +U01 DA019378-01/DA/NIDA NIH HHS/ +U01 DA019378/DA/NIDA NIH HHS/ +T32 DA015036-11/DA/NIDA NIH HHS/ +K01 DA029645-01A1/DA/NIDA NIH HHS/ +K01DA029645/DA/NIDA NIH HHS/ +R21DA027877/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +U01DA019378/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Ireland +Drug Alcohol Depend. 2012 Oct 1;125(3):252-9. doi: 10.1016/j.drugalcdep.2012.02.020. Epub 2012 Mar 27.}, + abstract = {BACKGROUND: Brain dysfunction in prefrontal cortex (PFC) and dorsal striatum (DS) contributes to habitual drug use. These regions are constituents of brain networks thought to be involved in drug addiction. To investigate whether networks containing these regions differ between nicotine dependent female smokers and age-matched female non-smokers, we employed functional MRI (fMRI) at rest. METHODS: Data were processed with independent component analysis (ICA) to identify resting state networks (RSNs). We identified a subcortical limbic network and three discrete PFC networks: a medial prefrontal cortex (mPFC) network and right and left lateralized fronto-parietal networks common to all subjects. We then compared these RSNs between smokers and non-smokers using a dual regression approach. RESULTS: Smokers had greater coupling versus non-smokers between left fronto-parietal and mPFC networks. Smokers with the greatest mPFC-left fronto-parietal coupling had the most DS smoking cue reactivity as measured during an fMRI smoking cue reactivity paradigm. This may be important because the DS plays a critical role in maintaining drug-cue associations. Furthermore, subcortical limbic network amplitude was greater in smokers. CONCLUSIONS: Our results suggest that prefrontal brain networks are more strongly coupled in smokers, which could facilitate drug-cue responding. Our data also are the first to document greater reward-related network fMRI amplitude in smokers. Our findings suggest that resting state PFC network interactions and limbic network amplitude can differentiate nicotine-dependent smokers from controls, and may serve as biomarkers for nicotine dependence severity and treatment efficacy.}, + keywords = {Adult +Cues +Diagnostic and Statistical Manual of Mental Disorders +Female +Humans +Image Processing, Computer-Assisted +Limbic System/drug effects/*physiology +Magnetic Resonance Imaging +Male +Middle Aged +Nerve Net/drug effects/*physiology +Parietal Lobe/drug effects/physiology +Prefrontal Cortex/drug effects/*physiology +Principal Component Analysis +Regression Analysis +Rest/physiology +Smoking/*physiopathology/psychology +Tobacco Use Disorder/*physiopathology/psychology}, + ISSN = {1879-0046 (Electronic) +0376-8716 (Linking)}, + DOI = {10.1016/j.drugalcdep.2012.02.020}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/22459914}, + year = {2012}, + type = {Journal Article} +} + +@article{RN3640, + author = {Janes, A. C. and Pizzagalli, D. A. and Richardt, S. and de, B. Frederick B. and Chuzi, S. and Pachas, G. and Culhane, M. A. and Holmes, A. J. and Fava, M. and Evins, A. E. and Kaufman, M. J.}, + title = {Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence}, + journal = {Biol Psychiatry}, + volume = {67}, + number = {8}, + pages = {722-9}, + note = {Janes, Amy C +Pizzagalli, Diego A +Richardt, Sarah +deB Frederick, Blaise +Chuzi, Sarah +Pachas, Gladys +Culhane, Melissa A +Holmes, Avram J +Fava, Maurizio +Evins, A Eden +Kaufman, Marc J +eng +R01DA014674/DA/NIDA NIH HHS/ +R01 DA009448/DA/NIDA NIH HHS/ +K02DA017324/DA/NIDA NIH HHS/ +K02 DA017324/DA/NIDA NIH HHS/ +R01 DA014674/DA/NIDA NIH HHS/ +T32DA015036/DA/NIDA NIH HHS/ +U01 DA019378-01/DA/NIDA NIH HHS/ +R01DA09448/DA/NIDA NIH HHS/ +U01 DA019378/DA/NIDA NIH HHS/ +R01DA022276/DA/NIDA NIH HHS/ +R01 DA022276/DA/NIDA NIH HHS/ +K02 DA017324-01/DA/NIDA NIH HHS/ +T32 DA015036-01/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +U01DA019378/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +Research Support, U.S. Gov't, Non-P.H.S. +Biol Psychiatry. 2010 Apr 15;67(8):722-9. doi: 10.1016/j.biopsych.2009.12.034. Epub 2010 Feb 20.}, + abstract = {BACKGROUND: Developing the means to identify smokers at high risk for relapse could advance relapse prevention therapy. We hypothesized that functional magnetic resonance imaging (fMRI) reactivity to smoking-related cues, measured before a quit attempt, could identify smokers with heightened relapse vulnerability. METHODS: Before quitting smoking, 21 nicotine-dependent women underwent fMRI during which smoking-related and neutral images were shown. These smokers also were tested for possible attentional biases to smoking-related words using a computerized emotional Stroop (ES) task previously found to predict relapse. Smokers then made a quit attempt and were grouped based on outcomes (abstinence vs. slip: smoking > or = 1 cigarette after attaining abstinence). Prequit fMRI and ES measurements in these groups were compared. RESULTS: Slip subjects had heightened fMRI reactivity to smoking-related images in brain regions implicated in emotion, interoceptive awareness, and motor planning and execution. Insula and dorsal anterior cingulate cortex (dACC) reactivity induced by smoking images correlated with an attentional bias to smoking-related words. A discriminant analysis of ES and fMRI data predicted outcomes with 79% accuracy. Additionally, smokers who slipped had decreased fMRI functional connectivity between an insula-containing network and brain regions involved in cognitive control, including the dACC and dorsal lateral prefrontal cortex, possibly reflecting reduced top-down control of cue-induced emotions. CONCLUSIONS: These findings suggest that the insula and dACC are important substrates of smoking relapse vulnerability. The data also suggest that relapse-vulnerable smokers can be identified before quit attempts, which could enable personalized treatment, improve tobacco-dependence treatment outcomes, and reduce smoking-related morbidity and mortality.}, + keywords = {Adult +Brain/*physiology +Cerebral Cortex/physiology +*Cues +Emotions/physiology +Female +Humans +Image Processing, Computer-Assisted +Magnetic Resonance Imaging +Middle Aged +Neural Pathways/physiology +Neuropsychological Tests +Principal Component Analysis +Psychiatric Status Rating Scales +Smoking/*psychology +Smoking Cessation/*psychology +Treatment Outcome}, + ISSN = {1873-2402 (Electronic) +0006-3223 (Linking)}, + DOI = {10.1016/j.biopsych.2009.12.034}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/20172508}, + year = {2010}, + type = {Journal Article} +} + +@article{RN551, + author = {Janes, A. C. and Pizzagalli, D. A. and Richardt, S. and Frederick, B. D. and Chuzi, S. and Pachas, G. and Culhane, M. A. and Holmes, A. J. and Fava, M. and Evins, A. E. and Kaufman, M. J.}, + title = {Brain Reactivity to Smoking Cues Prior to Smoking Cessation Predicts Ability to Maintain Tobacco Abstinence}, + journal = {Biological Psychiatry}, + volume = {67}, + number = {8}, + pages = {722-729}, + note = {Janes, Amy C. Pizzagalli, Diego A. Richardt, Sarah Frederick, Blaise deB. Chuzi, Sarah Pachas, Gladys Culhane, Melissa A. Holmes, Avram J. Fava, Maurizio Evins, A. Eden Kaufman, Marc J.}, + abstract = {Background: Developing the means to identify smokers at high risk for relapse could advance relapse prevention therapy. We hypothesized that functional magnetic resonance imaging (fMRI) reactivity to smoking-related cues, measured before a quit attempt, could identify smokers with heightened relapse vulnerability. Methods: Before quitting smoking, 21 nicotine-dependent women underwent fMRI during which smoking-related and neutral images were shown. These smokers also were tested for possible attentional biases to smoking-related words using a computerized emotional Stroop (ES) task previously found to predict relapse. Smokers then made a quit attempt and were grouped based on outcomes (abstinence vs. slip: smoking >= 1 cigarette after attaining abstinence). Prequit fMRI and ES measurements in these groups were compared. Results: Slip subjects had heightened fMRI reactivity to smoking-related images in brain regions implicated in emotion, interoceptive awareness, and motor planning and execution. Insula and dorsal anterior cingulate cortex (dACC) reactivity induced by smoking images correlated with an attentional bias to smoking-related words. A discriminant analysis of ES and fMRI data predicted outcomes with 79% accuracy. Additionally, smokers who slipped had decreased fMRI functional connectivity between an insula-containing network and brain regions involved in cognitive control, including the dACC and dorsal lateral prefrontal cortex, possibly reflecting reduced top-down control of cue-induced emotions. Conclusions: These findings suggest that the insula and dACC are important substrates of smoking relapse vulnerability. The data also suggest that relapse-vulnerable smokers can be identified before quit attempts, which could enable personalized treatment, improve tobacco-dependence treatment outcomes, and reduce smoking-related morbidity and mortality.}, + ISSN = {0006-3223}, + DOI = {10.1016/j.biopsych.2009.12.034}, + url = {://WOS:000276732600005}, + year = {2010}, + type = {Journal Article} +} + +@article{RN550, + author = {Janes, A. C. and Pizzagalli, D. A. and Richardt, S. and Frederick, B. D. and Chuzi, S. and Pachas, G. and Culhane, M. A. and Holmes, A. J. and Fava, M. and Evins, A. E. and Kaufman, M. J.}, + title = {Brain Reactivity to Smoking Cues Prior to Smoking Cessation Predicts Ability to Maintain Tobacco Abstinence (vol 67, pg 722, 2010)}, + journal = {Biological Psychiatry}, + volume = {67}, + number = {10}, + pages = {1002-1002}, + note = {Janes, A. C. Pizzagalli, D. A. Richardt, S. Frederick, B. D. Chuzi, S. Pachas, G. Culhane, M. A. Holmes, A. J. Fava, M. Evins, A. E. Kaufman, M. J.}, + ISSN = {0006-3223}, + DOI = {10.1016/j.biopsych.2010.03.020}, + url = {://WOS:000277629900015}, + year = {2010}, + type = {Journal Article} +} + +@article{RN557, + author = {Janes, A. C. and Pizzagalli, D. A. and Richardt, S. and Frederick, B. D. and Holmes, A. J. and Sousa, J. and Fava, M. and Evins, A. E. and Kaufman, M. J.}, + title = {Neural Substrates of Attentional Bias for Smoking-Related Cues: An fMRI Study}, + journal = {Neuropsychopharmacology}, + volume = {35}, + number = {12}, + pages = {2339-2345}, + note = {Janes, Amy C. Pizzagalli, Diego A. Richardt, Sarah Frederick, Blaise de B. Holmes, Avram J. Sousa, Jessica Fava, Maurizio Evins, A. Eden Kaufman, Marc J.}, + abstract = {Attentional bias for drug-related stimuli, as measured by emotional Stroop (ES) tasks, is predictive of treatment outcomes for tobacco smoking and other abused drugs. Characterizing relationships between smoking-related attentional bias and brain reactivity to smoking images may help in identifying neural substrates critical to relapse vulnerability. To this end, we investigated putative relationships between interference effects in an offline smoking ES task and functional MRI (fMRI) measures of brain reactivity to smoking vs neutral images in women smokers. Positive correlations were found between attentional bias and reactivity to smoking images in brain areas involved in emotion, memory, interoception, and visual processing, including the amygdala, hippocampus, parahippocampal gyrus, insula, and occipital cortex. These findings suggest that smokers with elevated attentional biases to smoking-related stimuli may more readily shift attention away from other external stimuli and toward smoking stimuli-induced internal states and emotional memories. Such attentional shifts may contribute to increased interference by smoking cues, possibly increasing relapse vulnerability. Treatments capable of inhibiting shifts to drug cue-induced memories and internal states may lead to personalized tobacco dependence treatment for smokers with high attentional bias to smoking-related stimuli. Neuropsychopharmacology (2010) 35, 2339-2345; doi: 10.1038/npp.2010.103; published online 11 August 2010}, + ISSN = {0893-133X}, + DOI = {10.1038/npp.2010.103}, + url = {://WOS:000282960200004}, + year = {2010}, + type = {Journal Article} +} + +@article{RN3658, + author = {Janes, A. C. and Pizzagalli, D. A. and Richardt, S. and Frederick Bde, B. and Holmes, A. J. and Sousa, J. and Fava, M. and Evins, A. E. and Kaufman, M. J.}, + title = {Neural substrates of attentional bias for smoking-related cues: an FMRI study}, + journal = {Neuropsychopharmacology}, + volume = {35}, + number = {12}, + pages = {2339-45}, + note = {Janes, Amy C +Pizzagalli, Diego A +Richardt, Sarah +Frederick, Blaise de B +Holmes, Avram J +Sousa, Jessica +Fava, Maurizio +Evins, A Eden +Kaufman, Marc J +eng +T32 DA015036-09/DA/NIDA NIH HHS/ +R01 DA022276-03/DA/NIDA NIH HHS/ +K02 DA017324-05/DA/NIDA NIH HHS/ +K02 DA017324/DA/NIDA NIH HHS/ +U01 DA019378-01/DA/NIDA NIH HHS/ +K24 DA030443/DA/NIDA NIH HHS/ +U01 DA019378-02/DA/NIDA NIH HHS/ +U01 DA019378/DA/NIDA NIH HHS/ +R01 DA022276/DA/NIDA NIH HHS/ +U01 DA019378-05/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +U01 DA019378-04/DA/NIDA NIH HHS/ +R01 DA022276-01/DA/NIDA NIH HHS/ +U01 DA019378-03/DA/NIDA NIH HHS/ +R01 DA022276-02/DA/NIDA NIH HHS/ +England +Neuropsychopharmacology. 2010 Nov;35(12):2339-45. doi: 10.1038/npp.2010.103. Epub 2010 Aug 11.}, + abstract = {Attentional bias for drug-related stimuli, as measured by emotional Stroop (ES) tasks, is predictive of treatment outcomes for tobacco smoking and other abused drugs. Characterizing relationships between smoking-related attentional bias and brain reactivity to smoking images may help in identifying neural substrates critical to relapse vulnerability. To this end, we investigated putative relationships between interference effects in an offline smoking ES task and functional MRI (fMRI) measures of brain reactivity to smoking vs neutral images in women smokers. Positive correlations were found between attentional bias and reactivity to smoking images in brain areas involved in emotion, memory, interoception, and visual processing, including the amygdala, hippocampus, parahippocampal gyrus, insula, and occipital cortex. These findings suggest that smokers with elevated attentional biases to smoking-related stimuli may more readily shift attention away from other external stimuli and toward smoking stimuli-induced internal states and emotional memories. Such attentional shifts may contribute to increased interference by smoking cues, possibly increasing relapse vulnerability. Treatments capable of inhibiting shifts to drug cue-induced memories and internal states may lead to personalized tobacco dependence treatment for smokers with high attentional bias to smoking-related stimuli.}, + keywords = {Adult +*Attention +Brain/*physiopathology +*Cues +Emotions/physiology +Female +Humans +Internal-External Control +Magnetic Resonance Imaging +Memory/physiology +Middle Aged +Smoking/*psychology +Stroop Test +Tobacco Use Disorder/*physiopathology/psychology}, + ISSN = {1740-634X (Electronic) +0893-133X (Linking)}, + DOI = {10.1038/npp.2010.103}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/20703221}, + year = {2010}, + type = {Journal Article} +} + +@article{RN2633, + author = {Janes, A. C. and Ross, R. S. and Farmer, S. and Frederick, B. B. and Nickerson, L. D. and Lukas, S. E. and Stern, C. E.}, + title = {Memory retrieval of smoking-related images induce greater insula activation as revealed by an fMRI-based delayed matching to sample task}, + journal = {Addict Biol}, + volume = {20}, + number = {2}, + pages = {349-56}, + note = {Janes, Amy C +Ross, Robert S +Farmer, Stacey +Frederick, Blaise B +Nickerson, Lisa D +Lukas, Scott E +Stern, Chantal E +eng +K01 DA029645/DA/NIDA NIH HHS/ +K01DA029645/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Addict Biol. 2015 Mar;20(2):349-56. doi: 10.1111/adb.12112. Epub 2013 Nov 22.}, + abstract = {Nicotine dependence is a chronic and difficult to treat disorder. While environmental stimuli associated with smoking precipitate craving and relapse, it is unknown whether smoking cues are cognitively processed differently than neutral stimuli. To evaluate working memory differences between smoking-related and neutral stimuli, we conducted a delay-match-to-sample (DMS) task concurrently with functional magnetic resonance imaging (fMRI) in nicotine-dependent participants. The DMS task evaluates brain activation during the encoding, maintenance and retrieval phases of working memory. Smoking images induced significantly more subjective craving, and greater midline cortical activation during encoding in comparison to neutral stimuli that were similar in content yet lacked a smoking component. The insula, which is involved in maintaining nicotine dependence, was active during the successful retrieval of previously viewed smoking versus neutral images. In contrast, neutral images required more prefrontal cortex-mediated active maintenance during the maintenance period. These findings indicate that distinct brain regions are involved in the different phases of working memory for smoking-related versus neutral images. Importantly, the results implicate the insula in the retrieval of smoking-related stimuli, which is relevant given the insula's emerging role in addiction.}, + keywords = {Adolescent +Adult +Cerebral Cortex/physiology +Craving +Cues +Female +Functional Neuroimaging +Humans +Magnetic Resonance Imaging +Male +Memory/physiology +Memory, Short-Term/*physiology +Photic Stimulation +Prefrontal Cortex/*physiology +Smoking/*psychology +Tobacco Use Disorder/*psychology +Young Adult +Insula +memory +nicotine dependence}, + ISSN = {1369-1600 (Electronic) +1355-6215 (Linking)}, + DOI = {10.1111/adb.12112}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/24261848}, + year = {2015}, + type = {Journal Article} +} + +@article{RN556, + author = {Janes, A. C. and Smoller, J. W. and David, S. P. and Frederick, B. D. and Haddad, S. and Basu, A. and Fava, M. and Evins, A. E. and Kaufman, M. J.}, + title = {Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women}, + journal = {Drug and Alcohol Dependence}, + volume = {120}, + number = {1-3}, + pages = {7-13}, + note = {Janes, Amy C. Smoller, Jordan W. David, Sean P. Frederick, Blaise deB. Haddad, Stephen Basu, Aditi Fava, Maurizio Evins, A. Eden Kaufman, Marc J.}, + abstract = {Background: Tobacco smoking is the leading preventable cause of death in the developed world. Identifying risk factors for smoking may lead to more effective treatments. Genome wide association studies revealed a relationship between development of nicotine dependence and a single-nucleotide polymorphism (SNP, rs16969968) of the nicotine acetylcholine receptor (nAChR) alpha-5 subunit gene (CHRNA5). The relationship between this SNP and other factors contributing to smoking behavior such as smoking cue reactivity is unclear. Methods: We assessed the role of rs16969968 on brain functional MRI (fMRI) reactivity to smoking cues by studying nicotine dependent women with the nicotine dependence 'risk' allele (A allele, N = 14) and without the 'risk' allele (G/G smokers, N = 10). Nicotine dependence severity, as assessed with the Fagerstrom test for nicotine dependence, smoking pack-years, and expired carbon monoxide levels, were equivalent in these groups. Results: We observed a group difference in fMRI reactivity; women without the A allele (G/G smokers) showed greater fMRI reactivity to smoking images in brain areas related to memory and habitual behavior such as the hippocampus and dorsal striatum. Conclusions: Our finding suggests that nicotine-dependent smokers lacking the rs16969968 A allele are more likely to recall smoking-related memories and engage in habitual responding to smoking cues than A allele smokers. Although more studies are necessary to determine the mechanism underlying and significance of this cue reactivity difference, these data suggest that smokers may develop and remain nicotine dependent due to different factors including genetics and cue reactivity. This finding may have implications for personalizing smoking treatment. (C) 2011 Elsevier Ireland Ltd. All rights reserved.}, + ISSN = {0376-8716}, + DOI = {10.1016/j.drugalcdep.2011.06.009}, + url = {://WOS:000299499800002}, + year = {2012}, + type = {Journal Article} +} + +@article{RN3641, + author = {Janes, A. C. and Smoller, J. W. and David, S. P. and Frederick, B. D. and Haddad, S. and Basu, A. and Fava, M. and Evins, A. E. and Kaufman, M. J.}, + title = {Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women}, + journal = {Drug Alcohol Depend}, + volume = {120}, + number = {1-3}, + pages = {7-13}, + note = {Janes, Amy C +Smoller, Jordan W +David, Sean P +Frederick, Blaise Deb +Haddad, Stephen +Basu, Aditi +Fava, Maurizio +Evins, A Eden +Kaufman, Marc J +eng +R01DA014674/DA/NIDA NIH HHS/ +R24 GM061374/GM/NIGMS NIH HHS/ +K02DA017324/DA/NIDA NIH HHS/ +K02 DA017324/DA/NIDA NIH HHS/ +K01 DA029645/DA/NIDA NIH HHS/ +R01 DA014674/DA/NIDA NIH HHS/ +T32DA015036/DA/NIDA NIH HHS/ +U01 DA019378-01/DA/NIDA NIH HHS/ +K24 DA030443/DA/NIDA NIH HHS/ +R01DA09448/DA/NIDA NIH HHS/ +R24 GM061374-11/GM/NIGMS NIH HHS/ +U01 DA019378/DA/NIDA NIH HHS/ +R21 DA027331-01A1/DA/NIDA NIH HHS/ +R01DA022276/DA/NIDA NIH HHS/ +R01 DA022276/DA/NIDA NIH HHS/ +K01 DA029645-01A1/DA/NIDA NIH HHS/ +K02 DA017324-01/DA/NIDA NIH HHS/ +R21DA027331/DA/NIDA NIH HHS/ +T32 DA015036-01/DA/NIDA NIH HHS/ +R01 DA009448-12/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +U01DA019378/DA/NIDA NIH HHS/ +R24GM61374/GM/NIGMS NIH HHS/ +R01 DA022276-01/DA/NIDA NIH HHS/ +R21 DA027331/DA/NIDA NIH HHS/ +R01 DA014674-01A1/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, U.S. Gov't, Non-P.H.S. +Ireland +Drug Alcohol Depend. 2012 Jan 1;120(1-3):7-13. doi: 10.1016/j.drugalcdep.2011.06.009. Epub 2011 Jul 20.}, + abstract = {BACKGROUND: Tobacco smoking is the leading preventable cause of death in the developed world. Identifying risk factors for smoking may lead to more effective treatments. Genome wide association studies revealed a relationship between development of nicotine dependence and a single-nucleotide polymorphism (SNP, rs16969968) of the nicotine acetylcholine receptor (nAChR) alpha-5 subunit gene (CHRNA5). The relationship between this SNP and other factors contributing to smoking behavior such as smoking cue reactivity is unclear. METHODS: We assessed the role of rs16969968 on brain functional MRI (fMRI) reactivity to smoking cues by studying nicotine dependent women with the nicotine dependence 'risk' allele (A allele, N=14) and without the 'risk' allele (G/G smokers, N=10). Nicotine dependence severity, as assessed with the Fagerstrom test for nicotine dependence, smoking pack-years, and expired carbon monoxide levels, were equivalent in these groups. RESULTS: We observed a group difference in fMRI reactivity; women without the A allele (G/G smokers) showed greater fMRI reactivity to smoking images in brain areas related to memory and habitual behavior such as the hippocampus and dorsal striatum. CONCLUSIONS: Our finding suggests that nicotine-dependent smokers lacking the rs16969968 A allele are more likely to recall smoking-related memories and engage in habitual responding to smoking cues than A allele smokers. Although more studies are necessary to determine the mechanism underlying and significance of this cue reactivity difference, these data suggest that smokers may develop and remain nicotine dependent due to different factors including genetics and cue reactivity. This finding may have implications for personalizing smoking treatment.}, + keywords = {Adult +Alleles +Brain/*physiopathology +Cues +Female +Functional Neuroimaging +Humans +Magnetic Resonance Imaging +Middle Aged +Nerve Tissue Proteins/*genetics +Polymorphism, Single Nucleotide/genetics +Receptors, Nicotinic/*genetics +Smoking/genetics/*physiopathology/psychology +Tobacco Use Disorder/*genetics/physiopathology/psychology}, + ISSN = {1879-0046 (Electronic) +0376-8716 (Linking)}, + DOI = {10.1016/j.drugalcdep.2011.06.009}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/21764527}, + year = {2012}, + type = {Journal Article} +} + +@article{RN530, + author = {Jensen, J. E. and Frederick, B. D. and Renshaw, P. F.}, + title = {Grey and white matter GABA level differences in the human brain using two-dimensional, J-resolved spectroscopic imaging}, + journal = {Nmr in Biomedicine}, + volume = {18}, + number = {8}, + pages = {570-576}, + note = {Jensen, JE Frederick, BD Renshaw, PF}, + abstract = {A novel, two-dimensional, J-resolved chemical-shift imaging sequence was used to collect gamma-aminobutyric acid (GABA) spectroscopic imaging data on six healthy subjects at 4T. Using image segmentation and a linear-regression analysis relating brain GABA level to tissue-type, a consistent and significant (n = 6, p < 0.01) elevation of mean GABA levels was measured in the cortical grey matter (0.96 +/- 0.24 mm) compared with white matter (0.44 +/- 0.16 mm) across all six subjects. The results suggest an approximately two-fold elevation of GABA levels in cortical grey matter compared with white matter in vivo. Our findings are consistent with ex vivo studies in the literature of both animal and human brain and demonstrate the significant potential of this technique for detecting and quantifying tissue-specific neurochemical pathology in vivo. Copyright (c) 2005 John Wiley & Sons, Ltd.}, + ISSN = {0952-3480}, + DOI = {10.1002/nbm.994}, + url = {://WOS:000234281400011}, + year = {2005}, + type = {Journal Article} +} + +@article{RN3653, + author = {Jensen, J. E. and Frederick, B. D. and Wang, L. and Brown, J. and Renshaw, P. F.}, + title = {Two-dimensional, J-resolved spectroscopic imaging of GABA at 4 Tesla in the human brain}, + journal = {Magn Reson Med}, + volume = {54}, + number = {4}, + pages = {783-8}, + note = {Jensen, J Eric +Frederick, Blaise Deb +Wang, Liqun +Brown, John +Renshaw, Perry F +eng +DA14013/DA/NIDA NIH HHS/ +Clinical Trial +Research Support, N.I.H., Extramural +Research Support, U.S. Gov't, P.H.S. +Magn Reson Med. 2005 Oct;54(4):783-8. doi: 10.1002/mrm.20644.}, + abstract = {A method for measuring brain gamma-amino butyric acid (GABA) levels is presented that combines 2D J-resolved magnetic resonance spectroscopy (J-MRS) techniques with chemical-shift imaging (2D-JMRSI) at 4 Tesla (T). The results of phantom and in vivo experiments agree well in demonstrating that the (2)CH(2) GABA resonance situated at 2.97 ppm can be resolved from the neighboring creatine (Cr) resonance at 3.03 ppm and quantified. Single-voxel, J-resolved standard and metabolite-nulled in vivo experiments on six healthy subjects reveal a broad component from the underlying macromolecules (MM) that resonates at and around 3.00 ppm, which is estimated to contribute approximately 15% to the J-resolved GABA resonance in this large voxel at a repetition time (TR) of 4.5 s. With our 2D-JMSRI at 1.25 s TR, the macromolecule resonance contribution to our GABA measurements is approximated to be 12%. Six healthy human subjects underwent scanning at 4T with this sequence, yielding a global brain GABA concentration of 0.76 +/- 0.20 mM after correction for 12% macromolecule contribution.}, + keywords = {*Algorithms +Brain/cytology/*metabolism +Humans +Image Interpretation, Computer-Assisted/*methods +Imaging, Three-Dimensional/methods +Magnetic Resonance Imaging/instrumentation/*methods +Magnetic Resonance Spectroscopy/instrumentation/*methods +Neurotransmitter Agents/analysis/metabolism +Phantoms, Imaging +Tissue Distribution +gamma-Aminobutyric Acid/analysis/*metabolism}, + ISSN = {0740-3194 (Print) +0740-3194 (Linking)}, + DOI = {10.1002/mrm.20644}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16155894}, + year = {2005}, + type = {Journal Article} +} + +@article{RN532, + author = {Jensen, J. E. and Frederick, B. D. and Wang, L. Q. and Brown, J. and Renshaw, P. F.}, + title = {Two-dimensional, J-resolved spectroscopic imaging of GABA at 4 Tesla in the human brain}, + journal = {Magnetic Resonance in Medicine}, + volume = {54}, + number = {4}, + pages = {783-788}, + note = {Jensen, JE Frederick, BD Wang, LQ Brown, J Renshaw, PF}, + abstract = {A method for measuring brain gamma-amino butyric acid (GABA) levels is presented that combines 2D J-resolved magnetic resonance spectroscopy (J-MRS) techniques with chemical-shift imaging (2D-JMRSI) at 4 Tesla (T). The results of phantom and in vivo experiments agree well in demonstrating that the (CH2)-C-2 GABA resonance situated at 2.97 ppm can be resolved from the neighboring creatine (Cr) resonance at 3.03 ppm and quantified. Single-voxel, J-resolved standard and metabolite-nulled in vivo experiments on six healthy subjects reveal a broad component from the underlying macromolecules (MM) that resonates at and around 3.00 ppm, which is estimated to contribute approximately 15% to the J-resolved GABA resonance in this large voxel at a repetition time (TR) of 4.5 s. With our 2D-JMSRI at 1.25 s TR, the macromolecule resonance contribution to our GABA measurements is approximated to be 12%. Six healthy human subjects underwent scanning at 4T with this sequence, yielding a global brain GABA concentration of 0.76 +/- 0.20 mM after correction for 12% macromolecule contribution.}, + ISSN = {0740-3194}, + DOI = {10.1002/mrm.20644}, + url = {://WOS:000232348000005}, + year = {2005}, + type = {Journal Article} +} + +@article{RN3662, + author = {Jensen, J. E. and Frederick Bde, B. and Renshaw, P. F.}, + title = {Grey and white matter GABA level differences in the human brain using two-dimensional, J-resolved spectroscopic imaging}, + journal = {NMR Biomed}, + volume = {18}, + number = {8}, + pages = {570-6}, + note = {Jensen, J Eric +Frederick, Blaise de B +Renshaw, Perry F +eng +DA14013/DA/NIDA NIH HHS/ +DA14178/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +England +NMR Biomed. 2005 Dec;18(8):570-6. doi: 10.1002/nbm.994.}, + abstract = {A novel, two-dimensional, J-resolved chemical-shift imaging sequence was used to collect gamma-aminobutyric acid (GABA) spectroscopic imaging data on six healthy subjects at 4 T. Using image segmentation and a linear-regression analysis relating brain GABA level to tissue-type, a consistent and significant (n = 6, p < 0.01) elevation of mean GABA levels was measured in the cortical grey matter (0.96 +/- 0.24 mm) compared with white matter (0.44 +/- 0.16 mm) across all six subjects. The results suggest an approximately two-fold elevation of GABA levels in cortical grey matter compared with white matter in vivo. Our findings are consistent with ex vivo studies in the literature of both animal and human brain and demonstrate the significant potential of this technique for detecting and quantifying tissue-specific neurochemical pathology in vivo.}, + keywords = {Animals +Brain/*anatomy & histology/*metabolism +Female +Humans +Magnetic Resonance Spectroscopy/*methods +Male +Regression Analysis +gamma-Aminobutyric Acid/*metabolism}, + ISSN = {0952-3480 (Print) +0952-3480 (Linking)}, + DOI = {10.1002/nbm.994}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16273508}, + year = {2005}, + type = {Journal Article} +} + +@article{RN535, + author = {Kaufman, M. J. and Henry, M. E. and Frederick, B. D. and Hennen, J. and Villafuerte, R. A. and Stoddard, E. P. and Schmidt, M. E. and Cohen, B. M. and Renshaw, P. F.}, + title = {Selective serotonin reuptake syndrome cingulate is associated with inhibitor discontinuation a rostral anterior choline metabolite decrease: A proton magnetic resonance spectroscopic imaging study}, + journal = {Biological Psychiatry}, + volume = {54}, + number = {5}, + pages = {534-539}, + note = {Kaufman, MJ Henry, ME Frederick, BD Hennen, J Villafuerte, RA Stoddard, EP Schmidt, ME Cohen, BM Renshaw, PF +9th Annual Meeting of the International-Society-for-Magnetic-Resonance-in-Medicine (ISMRM) +APR 21-27, 2001 +GLASGOW, SCOTLAND +Int Soc Magnet Resonance Med}, + abstract = {Background: The selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome (DS) is an important potential complication of treatment for major depression. We hypothesized that SSRI treatment discontinuation, resulting in change in clinical state, would be associated with reduced rostral anterior cingulate choline (Cho) metabolite ratios. Methods: Individuals with a DSM-III-R diagnosis of unipolar major depression who had been stabilized on paroxetine (n=13) or fluoxetine (n=13) were study subjects. They were monitored for change in clinical state (mood ratings, discontinuation symptoms) and underwent proton magnetic resonance spectroscopic imaging of the rostral anterior cingulate 3 days after medication substitution with active SSRI and placebo. Results: Placebo-day Cho/Cre (choline/total creatine) metabolite ratios were decreased in four paroxetine and two fluoxetine subjects meeting DS criteria, as compared with asymptomatic subjects (Mann-Whitney z=-2.31, p=.021). Conclusions: Discontinuation syndrome is associated with a rostral anterior cingulate Cho/Cre metabolite ratio decrease that may reflect dynamics of rostral anterior cingulate function.}, + ISSN = {0006-3223}, + DOI = {10.1016/s0006-3223(03)01828-0}, + url = {://WOS:000184906100005}, + year = {2003}, + type = {Journal Article} +} + +@article{RN3651, + author = {Kaufman, M. J. and Henry, M. E. and Frederick, Bd and Hennen, J. and Villafuerte, R. A. and Stoddard, E. P. and Schmidt, M. E. and Cohen, B. M. and Renshaw, P. F.}, + title = {Selective serotonin reuptake inhibitor discontinuation syndrome is associated with a rostral anterior cingulate choline metabolite decrease: a proton magnetic resonance spectroscopic imaging study}, + journal = {Biol Psychiatry}, + volume = {54}, + number = {5}, + pages = {534-9}, + note = {Kaufman, Marc J +Henry, Michael E +Frederick, Blaise deB +Hennen, John +Villafuerte, Rosemond A +Stoddard, Eve P +Schmidt, Mark E +Cohen, Bruce M +Renshaw, Perry F +eng +DA00329/DA/NIDA NIH HHS/ +DA09448/DA/NIDA NIH HHS/ +MH58681/MH/NIMH NIH HHS/ +Clinical Trial +Comparative Study +Controlled Clinical Trial +Research Support, Non-U.S. Gov't +Research Support, U.S. Gov't, P.H.S. +Biol Psychiatry. 2003 Sep 1;54(5):534-9.}, + abstract = {The selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome (DS) is an important potential complication of treatment for major depression. We hypothesized that SSRI treatment discontinuation, resulting in change in clinical state, would be associated with reduced rostral anterior cingulate choline (Cho) metabolite ratios. Individuals with a DSM-III-R diagnosis of unipolar major depression who had been stabilized on paroxetine (n = 13) or fluoxetine (n = 13) were study subjects. They were monitored for change in clinical state (mood ratings, discontinuation symptoms) and underwent proton magnetic resonance spectroscopic imaging of the rostral anterior cingulate 3 days after medication substitution with active SSRI and placebo.Placebo-day Cho/Cre (choline/total creatine) metabolite ratios were decreased in four paroxetine and two fluoxetine subjects meeting DS criteria, as compared with asymptomatic subjects (Mann-Whitney z = -2.31, p =.021). Discontinuation syndrome is associated with a rostral anterior cingulate Cho/Cre metabolite ratio decrease that may reflect dynamics of rostral anterior cingulate function.}, + keywords = {Adult +Brain Mapping +Choline/*metabolism +Depressive Disorder, Major/*drug therapy/metabolism +Female +Fluoxetine/adverse effects/therapeutic use +Gyrus Cinguli/*metabolism +Humans +Image Interpretation, Computer-Assisted +Magnetic Resonance Spectroscopy +Paroxetine/adverse effects/therapeutic use +Phosphocreatine/metabolism +Psychiatric Status Rating Scales +Serotonin Uptake Inhibitors/*adverse effects/therapeutic use +Substance Withdrawal Syndrome/etiology/*metabolism +Syndrome}, + ISSN = {0006-3223 (Print) +0006-3223 (Linking)}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/12946882}, + year = {2003}, + type = {Journal Article} +} + +@article{RN569, + author = {Kaufman, M. J. and Janes, A. C. and Frederick, Bd and Brimson-Theberge, M. and Tong, Y. and McWilliams, S. B. and Bear, A. and Gillis, T. E. and Schrode, K. M. and Renshaw, P. F. and Negus, S. S.}, + title = {A method for conducting functional MRI studies in alert nonhuman primates: initial results with opioid agonists in male cynomolgus monkeys}, + journal = {Exp Clin Psychopharmacol}, + volume = {21}, + number = {4}, + pages = {323-31}, + note = {Kaufman, Marc J +Janes, Amy C +Frederick, Blaise deB +Brimson-Theberge, Melanie +Tong, Yunjie +McWilliams, Samuel B +Bear, Ashley +Gillis, Timothy E +Schrode, Katrina M +Renshaw, Perry F +Negus, S Stevens +eng +R01 DA011460/DA/NIDA NIH HHS/ +K02 DA017324/DA/NIDA NIH HHS/ +K01 DA029645/DA/NIDA NIH HHS/ +K25 DA014013/DA/NIDA NIH HHS/ +K05 DA031247/DA/NIDA NIH HHS/ +R01 DA11460/DA/NIDA NIH HHS/ +T32 GM008471/GM/NIGMS NIH HHS/ +Comparative Study +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +Research Support, U.S. Gov't, Non-P.H.S. +Exp Clin Psychopharmacol. 2013 Aug;21(4):323-31. doi: 10.1037/a0033062. Epub 2013 Jun 17.}, + abstract = {Functional MRI (fMRI) has emerged as a powerful technique for assessing neural effects of psychoactive drugs and other stimuli. Several experimental approaches have been developed to use fMRI in anesthetized and awake animal subjects, each of which has its advantages and complexities. We sought to assess whether one particular method to scan alert postanesthetized animals can be used to assess fMRI effects of opioid agonists. To date, the use of fMRI as a method to compare pharmacological effects of opioid drugs has been limited. Such studies are important because mu and kappa opioid receptor agonists produce distinct profiles of behavioral effects related both to clinically desirable endpoints (e.g., analgesia) and to undesirable effects (e.g., abuse potential). This study sought to determine whether we could use our fMRI approach to compare acute effects of behaviorally equipotent (3.2 mug/kg) intravenous doses of fentanyl and U69,593 (doses that do not affect cardiorespiratory parameters). Scans were acquired in alert male cynomolgus macaques acclimated to undergo fMRI scans under restraint, absent excessive stress hormone increases. These opioid agonists activated bilateral striatal and nucleus accumbens regions of interest. At the dose tested, U69,593 induced greater left nucleus accumbens BOLD activation than fentanyl, while fentanyl activated left dorsal caudate nucleus more than U69,593. Our results suggest that our fMRI approach could be informative for comparing effects of opioid agonists.}, + keywords = {Adrenocorticotropic Hormone/blood +Analgesics, Opioid/administration & dosage/*pharmacology +Animals +Benzeneacetamides/administration & dosage/pharmacology +Caudate Nucleus/*drug effects/metabolism +Conditioning (Psychology) +Fentanyl/administration & dosage/pharmacology +Hydrocortisone/blood +Injections, Intravenous +Macaca fascicularis/*physiology +Magnetic Resonance Imaging/adverse effects/*veterinary +Male +Nerve Tissue Proteins/agonists/metabolism +Neurons/*drug effects/metabolism +Nucleus Accumbens/*drug effects/metabolism +Pyrrolidines/administration & dosage/pharmacology +Receptors, Opioid, kappa/agonists/metabolism +Receptors, Opioid, mu/agonists/metabolism +Restraint, Physical/adverse effects/veterinary +Stress, Physiological +Stress, Psychological/blood/etiology +Wakefulness}, + ISSN = {1936-2293 (Electronic) +1064-1297 (Linking)}, + DOI = {10.1037/a0033062}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/23773004}, + year = {2013}, + type = {Journal Article} +} + +@article{RN2458, + author = {Kaufman, M. J. and Janes, A. C. and Frederick, Bd and Brimson-Theberge, M. and Tong, Y. and McWilliams, S. B. and Bear, A. and Gillis, T. E. and Schrode, K. M. and Renshaw, P. F. and Negus, S. S.}, + title = {A method for conducting functional MRI studies in alert nonhuman primates: initial results with opioid agonists in male cynomolgus monkeys}, + journal = {Exp Clin Psychopharmacol}, + volume = {21}, + number = {4}, + pages = {323-31}, + note = {Kaufman, Marc J +Janes, Amy C +Frederick, Blaise deB +Brimson-Theberge, Melanie +Tong, Yunjie +McWilliams, Samuel B +Bear, Ashley +Gillis, Timothy E +Schrode, Katrina M +Renshaw, Perry F +Negus, S Stevens +eng +R01 DA011460/DA/NIDA NIH HHS/ +K02 DA017324/DA/NIDA NIH HHS/ +K01 DA029645/DA/NIDA NIH HHS/ +K25 DA014013/DA/NIDA NIH HHS/ +K05 DA031247/DA/NIDA NIH HHS/ +R01 DA11460/DA/NIDA NIH HHS/ +T32 GM008471/GM/NIGMS NIH HHS/ +Comparative Study +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +Research Support, U.S. Gov't, Non-P.H.S. +Exp Clin Psychopharmacol. 2013 Aug;21(4):323-31. doi: 10.1037/a0033062. Epub 2013 Jun 17.}, + abstract = {Functional MRI (fMRI) has emerged as a powerful technique for assessing neural effects of psychoactive drugs and other stimuli. Several experimental approaches have been developed to use fMRI in anesthetized and awake animal subjects, each of which has its advantages and complexities. We sought to assess whether one particular method to scan alert postanesthetized animals can be used to assess fMRI effects of opioid agonists. To date, the use of fMRI as a method to compare pharmacological effects of opioid drugs has been limited. Such studies are important because mu and kappa opioid receptor agonists produce distinct profiles of behavioral effects related both to clinically desirable endpoints (e.g., analgesia) and to undesirable effects (e.g., abuse potential). This study sought to determine whether we could use our fMRI approach to compare acute effects of behaviorally equipotent (3.2 mug/kg) intravenous doses of fentanyl and U69,593 (doses that do not affect cardiorespiratory parameters). Scans were acquired in alert male cynomolgus macaques acclimated to undergo fMRI scans under restraint, absent excessive stress hormone increases. These opioid agonists activated bilateral striatal and nucleus accumbens regions of interest. At the dose tested, U69,593 induced greater left nucleus accumbens BOLD activation than fentanyl, while fentanyl activated left dorsal caudate nucleus more than U69,593. Our results suggest that our fMRI approach could be informative for comparing effects of opioid agonists.}, + keywords = {Adrenocorticotropic Hormone/blood +Analgesics, Opioid/administration & dosage/*pharmacology +Animals +Benzeneacetamides/administration & dosage/pharmacology +Caudate Nucleus/*drug effects/metabolism +Conditioning (Psychology) +Fentanyl/administration & dosage/pharmacology +Hydrocortisone/blood +Injections, Intravenous +Macaca fascicularis/*physiology +Magnetic Resonance Imaging/adverse effects/*veterinary +Male +Nerve Tissue Proteins/agonists/metabolism +Neurons/*drug effects/metabolism +Nucleus Accumbens/*drug effects/metabolism +Pyrrolidines/administration & dosage/pharmacology +Receptors, Opioid, kappa/agonists/metabolism +Receptors, Opioid, mu/agonists/metabolism +Restraint, Physical/adverse effects/veterinary +Stress, Physiological +Stress, Psychological/blood/etiology +Wakefulness}, + ISSN = {1936-2293 (Electronic) +1064-1297 (Linking)}, + DOI = {10.1037/a0033062}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/23773004}, + year = {2013}, + type = {Journal Article} +} + +@article{RN512, + author = {Keltner, J. R. and Wald, L. L. and Frederick, B. D. and Renshaw, P. F.}, + title = {In vivo detection of GABA in human brain using a localized double-quantum filter technique}, + journal = {Magnetic Resonance in Medicine}, + volume = {37}, + number = {3}, + pages = {366-371}, + note = {Keltner, JR Wald, LL Frederick, BD Renshaw, PF}, + abstract = {A proton MR spectral editing technique employing a spatially localized, double-quantum filter (DQF) was used to measure gamma-aminobutyric acid (GABA) in the human brain at 1.5 T. The double-quantum method provided robust, single-shot suppression of uncoupled resonances from choline, creatine, and NAA and allowed detection of the gamma CH2 GABA (3.0 ppm) resonance with 30% efficiency. Spatial localization of the GABA measurement was achieved by incorporating PRESS localization within the double-quantum excitation and detection sequence, A calibration technique was developed to adjust the relative phases of the RF pulses to maximize the in vivo double-quantum detection efficiency for an arbitrary voxel location. The sequence efficiency, degree of suppression of uncoupled resonances, and characterization of the in vivo DQF technique was examined in phantom experiments and in a study of the occipital lobe of 10 normal subjects, The ratio of the 3.0-ppm GABA resonance to the 3.0-ppm creatine resonance was found to be 0.20 +/- 0.05 (SD).}, + ISSN = {0740-3194}, + DOI = {10.1002/mrm.1910370312}, + url = {://WOS:A1997WJ66400009}, + year = {1997}, + type = {Journal Article} +} + +@article{RN522, + author = {Levin, J. M. and Frederick, B. D. and Ross, M. H. and Fox, J. F. and von Rosenberg, H. L. and Kaufman, M. J. and Lange, N. and Mendelson, J. H. and Cohen, B. M. and Renshaw, P. F.}, + title = {Influence of baseline hematocrit and hemodilution on BOLD fMRI activation}, + journal = {Magnetic Resonance Imaging}, + volume = {19}, + number = {8}, + pages = {1055-1062}, + note = {Levin, JM Frederick, BD Ross, MH Fox, JF von Rosenberg, HL Kaufman, MJ Lange, N Mendelson, JH Cohen, BM Renshaw, PF}, + abstract = {Current understanding of blood oxygenation level dependent (BOLD) fMRI physiology predicts a close relationship between BOLD signal and blood hematocrit level. However, neither this relationship nor its effect on BOLD percent activation (BPA) has been empirically examined in man. To that end, BPA in primary visual cortex in response to photic stimulation was determined in a group of 24 normal subjects. A positive linear relationship between BPA and hematocrit was seen, particularly in men. To evaluate the effect of change in hematocrit on BPA, 9 men were studied before and following isotonic saline, hemodilution, resulting in an average 6% reduction in hematocrit and an 8-31% reduction in BPA. No significant change in the number of activated pixels was seen. A model of predicted BPA as a function of hematocrit and vessel size was developed, and results from this model closely mirrored the empiric data. These results suggest that hematocrit significantly influences the magnitude of BPA and that such baseline factors should be accounted for when comparing BOLD data across groups of subjects, particularly in the many instances in which hematocrit may vary systematically. Such instances include several disease states as well as studies involving sex differences, drug administration, stress and other factors. Finally, the robust agreement between predicted and empiric data serves to validate a semiquantitative approach to the analysis of BOLD fMRI data. (C) 2001 Elsevier Science Inc. All rights reserved.}, + ISSN = {0730-725X}, + DOI = {10.1016/s0730-725x(01)00460-x}, + url = {://WOS:000172312000002}, + year = {2001}, + type = {Journal Article} +} + +@article{RN2793, + author = {Levin, J. M. and Frederick Bde, B. and Ross, M. H. and Fox, J. F. and von Rosenberg, H. L. and Kaufman, M. J. and Lange, N. and Mendelson, J. H. and Cohen, B. M. and Renshaw, P. F.}, + title = {Influence of baseline hematocrit and hemodilution on BOLD fMRI activation}, + journal = {Magn Reson Imaging}, + volume = {19}, + number = {8}, + pages = {1055-62}, + note = {Levin, J M +Frederick, B de B +Ross, M H +Fox, J F +von Rosenberg, H L +Kaufman, M J +Lange, N +Mendelson, J H +Cohen, B M +Renshaw, P F +eng +DA00064/DA/NIDA NIH HHS/ +DA00297/DA/NIDA NIH HHS/ +DA00329/DA/NIDA NIH HHS/ +DA04059/DA/NIDA NIH HHS/ +DA09448/DA/NIDA NIH HHS/ +NS37483/NS/NINDS NIH HHS/ +Research Support, U.S. Gov't, P.H.S. +Netherlands +Magn Reson Imaging. 2001 Oct;19(8):1055-62.}, + abstract = {Current understanding of blood oxygenation level dependent (BOLD) fMRI physiology predicts a close relationship between BOLD signal and blood hematocrit level. However, neither this relationship nor its effect on BOLD percent activation (BPA) has been empirically examined in man. To that end, BPA in primary visual cortex in response to photic stimulation was determined in a group of 24 normal subjects. A positive linear relationship between BPA and hematocrit was seen, particularly in men. To evaluate the effect of change in hematocrit on BPA, 9 men were studied before and following isotonic saline hemodilution, resulting in an average 6% reduction in hematocrit and an 8-31% reduction in BPA. No significant change in the number of activated pixels was seen. A model of predicted BPA as a function of hematocrit and vessel size was developed, and results from this model closely mirrored the empiric data. These results suggest that hematocrit significantly influences the magnitude of BPA and that such baseline factors should be accounted for when comparing BOLD data across groups of subjects, particularly in the many instances in which hematocrit may vary systematically. Such instances include several disease states as well as studies involving sex differences, drug administration, stress and other factors. Finally, the robust agreement between predicted and empiric data serves to validate a semiquantitative approach to the analysis of BOLD fMRI data.}, + keywords = {Brain/blood supply/*physiology +Female +*Hematocrit +*Hemodilution +Humans +Magnetic Resonance Imaging/*methods +Male +Models, Biological +Oxygen/*blood +Photic Stimulation +Regression Analysis}, + ISSN = {0730-725X (Print) +0730-725X (Linking)}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/11711229}, + year = {2001}, + type = {Journal Article} +} + +@article{RN3624, + author = {Li, Y. and Zhang, H. and Yu, M. and Yu, W. and Frederick, B. D. and Tong, Y.}, + title = {Systemic low-frequency oscillations observed in the periphery of healthy human subjects}, + journal = {J Biomed Opt}, + volume = {23}, + number = {5}, + pages = {1-11}, + note = {Li, Yingwei +Zhang, Haibing +Yu, Meiling +Yu, Weiwei +Frederick, Blaise deB +Tong, Yunjie +eng +K25 DA031769/DA/NIDA NIH HHS/ +R01 NS097512/NS/NINDS NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +J Biomed Opt. 2018 May;23(5):1-11. doi: 10.1117/1.JBO.23.5.057001.}, + abstract = {This study investigated the relationships of systemic low-frequency oscillations (sLFOs) measured at different peripheral sites in resting state, during passive leg raising (PLR), and during a paced breathing (PB) test. Twenty-five healthy subjects (21 to 57 years old; males: 13 and females: 12) were recruited for these experiments. During the experiments, the fluctuations of oxyhemoglobin concentration were measured at six peripheral sites (left and right toes, fingertips, and earlobes) using a multichannel near-infrared spectroscopy instrument developed by our group. We applied cross-correlation and frequency component analyses on the data. The results showed that the sLFO signals in the symmetric peripheral sites were highly correlated, with time delays close to zero, whereas the correlation coefficients decreased between the sLFO signals of asymmetric sites, with delays up to several seconds. Furthermore, in PLR/PB tests, we found that PB caused wider and more robust changes in hemoglobin concentrations at peripheral sites compared to PLR. Among six peripheral sites, earlobes were the most sensitive to these perturbations, followed by fingertips, and then toes. Lastly, we showed that the perturbation signals may have different coupling mechanisms than the sLFO signals. The study deepened our understanding of the sLFO signals and establishes baseline measures for developing perfusion biomarkers to assess peripheral vascular integrity.}, + keywords = {near-infrared spectroscopy +paced breathing +passive leg raising +peripheral artery disease +peripheries +resting state +systemic low-frequency oscillations}, + ISSN = {1560-2281 (Electronic) +1083-3668 (Linking)}, + DOI = {10.1117/1.JBO.23.5.057001}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/29729091}, + year = {2018}, + type = {Journal Article} +} + +@article{RN561, + author = {Lindsey, K. P. and Bracken, B. K. and Maclean, R. R. and Ryan, E. T. and Lukas, S. E. and Frederick, B. D.}, + title = {Nicotine content and abstinence state have different effects on subjective ratings of positive versus negative reinforcement from smoking}, + journal = {Pharmacol Biochem Behav}, + abstract = {Despite the well-known adverse health consequences of smoking, approximately 20% of US adults smoke tobacco cigarettes. Much of the research on smoking reinforcement and the maintenance of tobacco smoking behavior have focused on nicotine; however, a number of other non-nicotine factors are likely to influence the reinforcing effects of smoked tobacco. A growing number of studies suggest that non-nicotine factors, through many pairings with nicotine, are partially responsible for the reinforcing effect of smoking. Additionally, both clinical studies and preclinical advances in our understanding of nicotinic receptor regulation suggest that abstinence from smoking may influence smoking reinforcement. These experiments were conducted for 2 reasons: to validate a MRI-compatible cigarette smoking device; and to simultaneously investigate the impact of nicotine, smoking-associated conditioned reinforcers, and smoking abstinence state on subjective ratings of smoking reinforcement. Participants smoked nicotine and placebo cigarettes through an fMRI compatible device in an overnight-abstinent state or in a nonabstinent state, after having smoked a cigarette 25minutes prior. Outcome measures were within-subject changes in physiology and subjective ratings of craving and drug effect during the smoking of nicotine or placebo cigarettes on different days in both abstinence states. Cigarette type (nicotine vs. placebo) had a significant effect on positive subjective ratings of smoking reinforcement ("High", "Like Drug", "Feel Drug"; nicotine>placebo). In contrast, abstinence state was found to have significant effects on both positive and negative ratings of smoking reinforcement ("Crave", "Anxiety", "Irritability"; abstinence>nonabstinence). Interaction effects between abstinence and nicotine provide clues about the importance of neuroadaptive mechanisms operating in dependence, as well as the impact of conditioned reinforcement on subjective ratings of smoking-induced high.}, + ISSN = {1873-5177}, + DOI = {10.1016/j.pbb.2012.11.012}, + url = {http://www.ncbi.nlm.nih.gov/pubmed/23219727}, + year = {2012}, + type = {Journal Article} +} + +@article{RN2635, + author = {Lindsey, K. P. and Bracken, B. K. and Maclean, R. R. and Ryan, E. T. and Lukas, S. E. and Frederick, B. D.}, + title = {Nicotine content and abstinence state have different effects on subjective ratings of positive versus negative reinforcement from smoking}, + journal = {Pharmacol Biochem Behav}, + volume = {103}, + number = {4}, + pages = {710-6}, + note = {Lindsey, Kimberly P +Bracken, Bethany K +Maclean, Robert R +Ryan, Elizabeth T +Lukas, Scott E +Frederick, Blaise Deb +eng +K25DA14013/DA/NIDA NIH HHS/ +K01 DA021730/DA/NIDA NIH HHS/ +R03 DA021231/DA/NIDA NIH HHS/ +T32 DA15036/DA/NIDA NIH HHS/ +R03DA021231/DA/NIDA NIH HHS/ +K25 DA014013/DA/NIDA NIH HHS/ +K01DA021730/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +K05DA00343/DA/NIDA NIH HHS/ +K05 DA000343/DA/NIDA NIH HHS/ +Comparative Study +Research Support, N.I.H., Extramural +Validation Studies +Pharmacol Biochem Behav. 2013 Feb;103(4):710-6. doi: 10.1016/j.pbb.2012.11.012. Epub 2012 Dec 3.}, + abstract = {Despite the well-known adverse health consequences of smoking, approximately 20% of US adults smoke tobacco cigarettes. Much of the research on smoking reinforcement and the maintenance of tobacco smoking behavior has focused on nicotine; however, a number of other non-nicotine factors are likely to influence the reinforcing effects of smoked tobacco. A growing number of studies suggest that non-nicotine factors, through many pairings with nicotine, are partially responsible for the reinforcing effect of smoking. Additionally, both clinical studies and preclinical advances in our understanding of nicotinic receptor regulation suggest that abstinence from smoking may influence smoking reinforcement. These experiments were conducted for 2 reasons: to validate a MRI-compatible cigarette smoking device; and to simultaneously investigate the impact of nicotine, smoking-associated conditioned reinforcers, and smoking abstinence state on subjective ratings of smoking reinforcement. Participants smoked nicotine and placebo cigarettes through an fMRI compatible device in an overnight-abstinent state or in a nonabstinent state, after having smoked a cigarette 25minutes prior. Outcome measures were within-subject changes in physiology and subjective ratings of craving and drug effect during the smoking of nicotine or placebo cigarettes on different days in both abstinence states. Cigarette type (nicotine vs. placebo) had a significant effect on positive subjective ratings of smoking reinforcement ("High", "Like Drug", "Feel Drug"; nicotine>placebo). In contrast, abstinence state was found to have significant effects on both positive and negative ratings of smoking reinforcement ("Crave", "Anxiety", "Irritability"; abstinence>nonabstinence). Interaction effects between abstinence and nicotine provide clues about the importance of neuroadaptive mechanisms operating in dependence, as well as the impact of conditioned reinforcement on subjective ratings of smoking-induced high.}, + keywords = {Adult +Behavior, Addictive/chemically induced/*psychology +Female +Humans +Male +Nicotine/*administration & dosage +*Reinforcement (Psychology) +Smoking/epidemiology/*psychology +Smoking Cessation/methods/*psychology +Young Adult}, + ISSN = {1873-5177 (Electronic) +0091-3057 (Linking)}, + DOI = {10.1016/j.pbb.2012.11.012}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/23219727}, + year = {2013}, + type = {Journal Article} +} + +@article{RN554, + author = {Lindsey, K. P. and Lukas, S. E. and MacLean, R. R. and Ryan, E. T. and Reed, K. R. and Frederick, B. D.}, + title = {Design and Validation of an Improved Nonferrous Smoking Device for Self-Administration of Smoked Drugs With Concurrent fMRI Neuroimaging}, + journal = {Clinical Eeg and Neuroscience}, + volume = {40}, + number = {1}, + pages = {21-30}, + note = {Lindsey, K. P. Lukas, S. E. MacLean, R. R. Ryan, E. T. Reed, K. R. Frederick, B. deB. +4th Joint Meeting of the EEG-and-Clinical-Neuroscience-Society/International-Society-for-NeuroIma ging-in-Psychiatry (ECNS-ISNIP) +SEP 19-23, 2007 +Montreal, CANADA +EEG & Clin Neurosci Soc, Int Soc Neuro Imaging Psychiat}, + abstract = {Several popularly abused drugs, such as nicotine (tobacco) and THC (triangle 9-tetrahydrocannabinol) (marihuana) are commonly self-administered by the smoked route. Although the neuronal substrates mediating the effect of smoked drugs are of interest, studies of their acute actions in living human brain has been difficult due to the unique constraints imposed by neuroimaging equipment and scanning environments. We have previously reported a device for the self-administration of smoked drugs with concurrent blood oxygen level dependent (BOLD) fMRI imaging. Here we report improvements to the device which result in improved drug delivery to the smoker. Gas chromatography/mass spectrometry (GCMS) analysis of nicotine recovered from filter extracts revealed that the amount of nicotine delivered to subjects smoking with our original device was reduced by approximately 44% compared to nicotine delivered by cigarettes smoked normally. Improvements were made to the smoke delivery component of our apparatus in an attempt to improve drug delivery, while not interfering with collection of MRI data. Nicotine plasma levels in 9 subjects smoking both with and without the improved smoking device in the laboratory were not significantly different. Similarly, the device produced no significant difference in either ratings of the subjective effects of nicotine, or changes in cardiovascular parameters in this experiment. The improved device does not interfere with typical drug effects produced by normal smoking. Phantom scans revealed that BOLD signal was not found to be altered by the (in-bore) installation and operation of the improved device. Preliminary data analysis of smoking induced changes in the BOLD response to visual stimulation suggest that this response is not affected by the improved device, the act of smoking, air puffing, nicotine, or other components of cigarette smoke. The improved device does not interfere with the collection of MRI neuroimaging data. Use of this device will facilitate investigations of the acute neuronal effects of smoked drugs.}, + ISSN = {1550-0594}, + url = {://WOS:000263585400005}, + year = {2009}, + type = {Journal Article} +} + +@article{RN516, + author = {Maas, L. C. and Frederick, B. D. and Renshaw, P. F.}, + title = {Decoupled rotational and translational image registration for functional MRI data sets}, + journal = {Biological Psychiatry}, + volume = {39}, + number = {7}, + pages = {480-480}, + note = {Maas, LC Frederick, BD Renshaw, PF}, + ISSN = {0006-3223}, + url = {://WOS:A1996UE89300465}, + year = {1996}, + type = {Journal Article} +} + +@article{RN514, + author = {Maas, L. C. and Frederick, B. D. and Renshaw, P. F.}, + title = {Decoupled automated rotational and translational registration for functional MRI time series data: The DART registration algorithm}, + journal = {Magnetic Resonance in Medicine}, + volume = {37}, + number = {1}, + pages = {131-139}, + note = {Maas, LC Frederick, BD Renshaw, PF +3rd Annual Meeting of the Society-of-Magnetic-Resonance +AUG 19-25, 1995 +NICE, FRANCE +Soc Magnet Resonance}, + abstract = {A rapid, in-plane image registration algorithm that accurately estimates and corrects for rotational and translational motion is described, This automated, one-pass method achieves its computational efficiency by decoupling the estimation of rotation and translation, allowing the application of rapid crosscorrelation and cross-spectrum techniques for the determination of displacement parameters, k-space regridding and modulation techniques are used for image correction as alternatives to linear interpolation, The performance of this method was analyzed with simulations and echo-planar image data from both phantoms and human subjects, The processing time for image registration on a Hewlett-Packard 735/125 is 7.5 s for a 128 x 128 pixel image and 1.7 s for a 64 x 64 pixel image, Imaging phantom data demonstrate the accuracy of the method (mean rotational error, -0.09 degrees; standard deviation = 0.17 degrees; range, -0.44 degrees to +0.31 degrees; mean translational error = -0.035 pixels; standard deviation = 0.054 pixels; range, -0.16 to +0.06 pixels). Registered human functional imaging data demonstrate a significant reduction in motion artifacts such as linear trends in pixel time series and activation artifacts due to stimulus-correlated motion, The advantages of this technique are its noniterative one-pass nature, the reduction in image degradation as compared to previous methods, and the speed of computation.}, + ISSN = {0740-3194}, + DOI = {10.1002/mrm.1910370119}, + url = {://WOS:A1997VZ62900018}, + year = {1997}, + type = {Journal Article} +} + +@article{RN515, + author = {Maas, L. C. and Frederick, B. D. and YurgelunTodd, D. A. and Renshaw, P. F.}, + title = {Autocovariance based analysis of functional MRI data}, + journal = {Biological Psychiatry}, + volume = {39}, + number = {7}, + pages = {479-479}, + note = {Maas, LC Frederick, BD YurgelunTodd, DA Renshaw, PF}, + ISSN = {0006-3223}, + url = {://WOS:A1996UE89300464}, + year = {1996}, + type = {Journal Article} +} + +@article{RN2632, + author = {Maher, S. and Ekstrom, T. and Tong, Y. and Nickerson, L. D. and Frederick, B. and Chen, Y.}, + title = {Greater sensitivity of the cortical face processing system to perceptually-equated face detection}, + journal = {Brain Res}, + volume = {1631}, + pages = {13-21}, + note = {Maher, S +Ekstrom, T +Tong, Y +Nickerson, L D +Frederick, B +Chen, Y +eng +R01 MH096793/MH/NIMH NIH HHS/ +R01MH096793/MH/NIMH NIH HHS/ +Research Support, N.I.H., Extramural +Netherlands +Brain Res. 2016 Jan 15;1631:13-21. doi: 10.1016/j.brainres.2015.11.011. Epub 2015 Nov 21.}, + abstract = {Face detection, the perceptual capacity to identify a visual stimulus as a face before probing deeper into specific attributes (such as its identity or emotion), is essential for social functioning. Despite the importance of this functional capacity, face detection and its underlying brain mechanisms are not well understood. This study evaluated the roles that the cortical face processing system, which is identified largely through studying other aspects of face perception, play in face detection. Specifically, we used functional magnetic resonance imaging (fMRI) to examine the activations of the fusifom face area (FFA), occipital face area (OFA) and superior temporal sulcus (STS) when face detection was isolated from other aspects of face perception and when face detection was perceptually-equated across individual human participants (n=20). During face detection, FFA and OFA were significantly activated, even for stimuli presented at perceptual-threshold levels, whereas STS was not. During tree detection, however, FFA and OFA were responsive only for highly salient (i.e., high contrast) stimuli. Moreover, activation of FFA during face detection predicted a significant portion of the perceptual performance levels that were determined psychophysically for each participant. This pattern of result indicates that FFA and OFA have a greater sensitivity to face detection signals and selectively support the initial process of face vs. non-face object perception.}, + keywords = {Adult +Aged +Brain/*physiology +Brain Mapping/methods +Cognition/physiology +Emotions/physiology +Face/physiology +Facial Recognition/*physiology +Female +Humans +Magnetic Resonance Imaging/methods +Male +Middle Aged +Occipital Lobe/physiology +Photic Stimulation +Psychophysics +Social Environment +Temporal Lobe/physiology +Visual Perception/*physiology +Cognition +Facial +Perception +Vision +Visual +fMRI}, + ISSN = {1872-6240 (Electronic) +0006-8993 (Linking)}, + DOI = {10.1016/j.brainres.2015.11.011}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/26592952}, + year = {2016}, + type = {Journal Article} +} + +@article{RN3644, + author = {Moore, C. M. and Breeze, J. L. and Gruber, S. A. and Babb, S. M. and Frederick, B. B. and Villafuerte, R. A. and Stoll, A. L. and Hennen, J. and Yurgelun-Todd, D. A. and Cohen, B. M. and Renshaw, P. F.}, + title = {Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex}, + journal = {Bipolar Disord}, + volume = {2}, + number = {3 Pt 2}, + pages = {207-16}, + note = {Moore, C M +Breeze, J L +Gruber, S A +Babb, S M +Frederick, B B +Villafuerte, R A +Stoll, A L +Hennen, J +Yurgelun-Todd, D A +Cohen, B M +Renshaw, P F +eng +MH58681/MH/NIMH NIH HHS/ +Research Support, Non-U.S. Gov't +Research Support, U.S. Gov't, P.H.S. +Denmark +Bipolar Disord. 2000 Sep;2(3 Pt 2):207-16.}, + abstract = {OBJECTIVES: Alterations in choline and myo-inositol metabolism have been noted in bipolar disorder, and the therapeutic efficacy of lithium in mania may be related to these effects. We wished to determine the relationship between anterior cingulate cortex choline and myo-inositol levels, assessed using proton magnetic resonance spectroscopic imaging (MRSI), and mood state in subjects with bipolar disorder. METHODS: Serial assessments of anterior cingulate cortex choline and myo-inositol metabolism were performed in nine subjects with bipolar disorder, taking either lithium or valproate, and 14 controls. Each bipolar subject was examined between one and four times (3.1 +/- 1.3). On the occasion of each examination, standardized ratings of both depression and mania were recorded. RESULTS: In the left cingulate cortex, the bipolar subjects' depression ratings correlated positively with MRSI measures of Cho/Cr-PCr. In the right cingulate cortex, the Cho/Cr-PCr ratio was significantly higher in subjects with bipolar disorder compared with control subjects. In addition, bipolar subjects not taking antidepressants had a significantly higher right cingulate cortex Cho/Cr-PCr ratio compared with patients taking antidepressants or controls. No clinical or drug-related changes were observed for the Ino/Cr-PCr ratio. CONCLUSIONS: The results of this study suggest that bipolar disorder is associated with alterations in the metabolism of cytosolic, choline-containing compounds in the anterior cingulate cortex. As this resonance arises primarily from phosphocholine and glycerophosphocholine, both of which are metabolites of phosphatidylcholine, these results are consistent with impaired intraneuronal signaling mechanisms.}, + keywords = {Adult +Affect/drug effects/*physiology +Bipolar Disorder/diagnosis/drug therapy/*physiopathology +Brain Mapping +Choline/*metabolism +Dominance, Cerebral/drug effects/physiology +Female +Gyrus Cinguli/drug effects/*physiopathology +Humans +Inositol/*metabolism +Lithium Carbonate/therapeutic use +*Magnetic Resonance Spectroscopy +Male +Middle Aged +Phosphocreatine/metabolism +Psychiatric Status Rating Scales +Valproic Acid/therapeutic use}, + ISSN = {1398-5647 (Print) +1398-5647 (Linking)}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/11249799}, + year = {2000}, + type = {Journal Article} +} + +@article{RN526, + author = {Moore, C. M. and Breeze, J. L. and Gruber, S. A. and Babb, S. M. and Frederick, B. D. and Villafuerte, R. A. and Stoll, A. L. and Hennen, J. and Yurgelun-Todd, D. A. and Cohen, B. M. and Renshaw, P. F.}, + title = {Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex}, + journal = {Bipolar Disorders}, + volume = {2}, + number = {3}, + pages = {207-216}, + note = {Moore, CM Breeze, JL Gruber, SA Babb, SM Frederick, BD Villafuerte, RA Stoll, AL Hennen, J Yurgelun-Todd, DA Cohen, BM Renshaw, PF +Part 2}, + abstract = {Objectives: Alterations in choline and myo-inositol metabolism have been noted in bipolar disorder, and the therapeutic efficacy of lithium in mania may be related to these effects. We wished to determine the relationship between anterior cingulate cortex choline and mfo-inositol levels, assessed using proton magnetic resonance spectroscopic imaging (MRSI), and mood state in subjects with bipolar disorder. Methods: Serial assessments of anterior cingulate cortex choline and myo-inositol metabolism were performed in nine subjects with bipolar disorder, taking either lithium or valproate, and 14 controls. Each bipolar subject was examined between one and four times (3.1 +/- 1.3). On the occasion of each examination, standardized ratings of both depression and mania were recorded. Results: In the left cingulate cortex; the bipolar subjects' depression ratings correlated positively with MRSI measures of Cho/Cr-PCr. In the right cingulate cortex, the Cho/Cr-PCr ratio was significantly higher in subjects with bipolar disorder compared with control subjects. In addition, bipolar subjects not taking antidepressants had a significantly higher right cingulate cortex Cho/Cr-PCr ratio compared with patients taking antidepressants or controls. No clinical or drug-related changes were observed for the Ino/Cr-PCr ratio. Conclusions: The results of this study suggest that bipolar disorder is associated with alterations in the metabolism of cytosolic, choline-containing compounds in the anterior cingulate cortex. As this resonance arises primarily from phosphocholine and glycerophosphocholine, both of which are metabolites of phosphatidylcholine, these results are consistent with impaired intraneuronal signaling mechanisms.}, + ISSN = {1398-5647}, + DOI = {10.1034/j.1399-5618.2000.20302.x}, + url = {://WOS:000168470300002}, + year = {2000}, + type = {Journal Article} +} + +@article{RN546, + author = {Moore, C. M. and Frazier, J. A. and Glod, C. A. and Breeze, J. L. and Dieterich, M. and Finn, C. T. and Frederick, B. D. and Renshaw, P. F.}, + title = {Glutamine and glutamate levels in children and adolescents with bipolar disorder: A 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex}, + journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, + volume = {46}, + number = {4}, + pages = {524-534}, + note = {Moore, Constance M. Frazier, Jean A. Glod, Carol A. Breeze, Janis L. Dieterich, Megan Finn, Chelsea T. Frederick, Blaise Deb. Renshaw, Perry F.}, + abstract = {Objective: The purpose of this study was to use proton magnetic resonance spectroscopy, at 4.0 T, to explore the glutamine and glutamate levels in the anterior cingulate cortex of children and adolescents with bipolar disorder (BPD; medicated and unmedicated) and healthy comparison subjects (HCSs). We hypothesized that unmedicated children with BPD would have reduced glutamine and glutamate levels compared with HCSs and medicated children with BPD. Method: Spectra were acquired from the anterior cingulate cortex in 22 children and adolescents with DSM-IV-TR BPD, type 1 (13 female: age 12.6 4.4 years: 7 of the subjects with BPD were unmedicated at the time of the scan) and 10 HCSs (7 female: age 12.3 +/- 2.5 years). Results: Unmedicated subjects with BPD had significantly lower glutamine levels than HCSs or medicated subjects with BPD. There were no differences in glutamate levels between the three groups. Conclusions: These results are consistent with there being an abnormality in anterior cingulate cortex glia in untreated children and adolescents with BPD. The results of this pilot study may be important in helping us better understand the pathophysiology of child and adolescent BPD. In addition, this observation may help to develop better and more targeted treatments, in particular those affecting the metabolism of glutamine, perhaps by regulation of glutamine synthetase activity.}, + ISSN = {0890-8567}, + DOI = {10.1097/chi.0b013e31802f5f2c}, + url = {://WOS:000245157800015}, + year = {2007}, + type = {Journal Article} +} + +@article{RN3655, + author = {Moore, C. M. and Frazier, J. A. and Glod, C. A. and Breeze, J. L. and Dieterich, M. and Finn, C. T. and Frederick, Bd and Renshaw, P. F.}, + title = {Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex}, + journal = {J Am Acad Child Adolesc Psychiatry}, + volume = {46}, + number = {4}, + pages = {524-34}, + note = {Moore, Constance M +Frazier, Jean A +Glod, Carol A +Breeze, Janis L +Dieterich, Megan +Finn, Chelsea T +Frederick, Blaise deB +Renshaw, Perry F +eng +K01 MH001978/MH/NIMH NIH HHS/ +MH01978/MH/NIMH NIH HHS/ +Research Support, N.I.H., Extramural +J Am Acad Child Adolesc Psychiatry. 2007 Apr;46(4):524-34. doi: 10.1097/chi.0b013e31802f5f2c.}, + abstract = {OBJECTIVE: The purpose of this study was to use proton magnetic resonance spectroscopy, at 4.0 T, to explore the glutamine and glutamate levels in the anterior cingulate cortex of children and adolescents with bipolar disorder (BPD; medicated and unmedicated) and healthy comparison subjects (HCSs). We hypothesized that unmedicated children with BPD would have reduced glutamine and glutamate levels compared with HCSs and medicated children with BPD. METHOD: Spectra were acquired from the anterior cingulate cortex in 22 children and adolescents with DSM-IV-TR BPD, type 1 (13 female: age 12.6 +/- 4.4 years: 7 of the subjects with BPD were unmedicated at the time of the scan) and 10 HCSs (7 female: age 12.3 +/- 2.5 years). RESULTS: Unmedicated subjects with BPD had significantly lower glutamine levels than HCSs or medicated subjects with BPD. There were no differences in glutamate levels between the three groups. CONCLUSIONS: These results are consistent with there being an abnormality in anterior cingulate cortex glia in untreated children and adolescents with BPD. The results of this pilot study may be important in helping us better understand the pathophysiology of child and adolescent BPD. In addition, this observation may help to develop better and more targeted treatments, in particular those affecting the metabolism of glutamine, perhaps by regulation of glutamine synthetase activity.}, + keywords = {Adolescent +Adult +Analysis of Variance +Bipolar Disorder/drug therapy/*pathology +Child +Child, Preschool +Female +Glutamic Acid/*metabolism +Glutamine/*metabolism +Gyrus Cinguli/*pathology +Humans +Magnetic Resonance Spectroscopy +Male +Neuroglia/pathology +Occipital Lobe/*pathology +Protons +Psychotropic Drugs/therapeutic use}, + ISSN = {0890-8567 (Print) +0890-8567 (Linking)}, + DOI = {10.1097/chi.0b013e31802f5f2c}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/17420688}, + year = {2007}, + type = {Journal Article} +} + +@article{RN536, + author = {Moore, C. M. and Frederick, B. D. and Henry, M. E. and Streeter, C. C. and Cohen, B. M. and Renshaw, P. F.}, + title = {Human in vivo lithium magnetic resonance spectroscopy at 4.0 tesla: Initial findings}, + journal = {Biological Psychiatry}, + volume = {53}, + number = {8}, + pages = {202S-202S}, + note = {Moore, CM Frederick, BD Henry, ME Streeter, CC Cohen, BM Renshaw, PF +58th Annual Convention and Scientific Program of the Society-of-Biological-Psychiatry +MAY 15-17, 2003 +SAN FRANCISCO, CALIFORNIA +Soc Bio Psychiatry +S}, + ISSN = {0006-3223}, + url = {://WOS:000182436000556}, + year = {2003}, + type = {Journal Article} +} + +@article{RN527, + author = {Moore, C. M. and Frederick, B. D. and Renshaw, P. F.}, + title = {Brain biochemistry using magnetic resonance spectroscopy: Relevance to psychiatric illness in the elderly}, + journal = {Journal of Geriatric Psychiatry and Neurology}, + volume = {12}, + number = {3}, + pages = {107-117}, + note = {Moore, CM Frederick, BD Renshaw, PF}, + abstract = {Magnetic resonance spectroscopy (MRS) allows for the noninvasive study of cerebral biochemistry. It has been used to investigate cerebral metabolic changes associated with mental illness in vivo and in vitro. In this review, we will discuss the application of MRS to psychiatric illness in the elderly. Following a brief description of the basic principles of MRS, the use of phosphorus (31P) and proton (1H) MRS to enable a better understanding of normal brain aging, dementia (Alzheimer's disease, multiple subcortical infarct dementia, Down syndrome, frontotemporal dementia, vascular dementia, age-associated memory impairment, and other dementias), major depression, and electroconvulsive therapy is detailed.}, + ISSN = {0891-9887}, + DOI = {10.1177/089198879901200304}, + url = {://WOS:000083882400003}, + year = {1999}, + type = {Journal Article} +} + +@article{RN3643, + author = {Moore, C. M. and Wardrop, M. and de, B. Frederick B. and Renshaw, P. F.}, + title = {Topiramate raises anterior cingulate cortex glutamine levels in healthy men; a 4.0 T magnetic resonance spectroscopy study}, + journal = {Psychopharmacology (Berl)}, + volume = {188}, + number = {2}, + pages = {236-43}, + note = {Moore, Constance M +Wardrop, Megan +deB Frederick, Blaise +Renshaw, Perry F +eng +K01 MH001978/MH/NIMH NIH HHS/ +DA014013/DA/NIDA NIH HHS/ +MH01978/MH/NIMH NIH HHS/ +Research Support, N.I.H., Extramural +Germany +Psychopharmacology (Berl). 2006 Oct;188(2):236-43. doi: 10.1007/s00213-006-0451-y. Epub 2006 Aug 31.}, + abstract = {RATIONALE: Potential mechanisms of action of topiramate include alterations of glutamatergic and GABAergic systems. In particular, topiramate has been shown to increase occipital cortex GABA levels, as measured using proton magnetic resonance spectroscopy (MRS). OBJECTIVES: The purpose of this study was to measure the effect of acute oral topiramate on the GABA precursors glutamate and glutamine in the anterior cingulate cortex (ACC) and occipital lobe (OL) using high-field (4.0 T) proton MRS (1H MRS). METHODS: Proton MR spectra were acquired from healthy men at three times: at baseline and 2 and 6 h after ingesting 50 (N=5) or 100 mg (N=5) of topiramate. Blood samples were acquired prior to each scan for the purpose of obtaining serum topiramate levels. RESULTS: A 100-mg dose of topiramate significantly increased ACC glutamine levels within 2 h of ingestion and OL glutamine levels within 6 h of ingestion. There were no measured significant effects of topiramate on ACC or OL glutamate levels. CONCLUSIONS: A 100-mg dose of oral topiramate increased serum topiramate and ACC glutamine levels within 2 h. OL glutamine levels increased within 6 h. Increased brain glutamine levels may be a consequence of topiramate positively modulating GABAA receptors. This result is of interest given the possible role for topiramate in the treatment of epilepsy, migraine headache, bipolar disorder, eating disorders, and alcohol dependence.}, + keywords = {Adolescent +Adult +Anticonvulsants/blood/*pharmacology +Fructose/*analogs & derivatives/blood/pharmacology +Glutamic Acid/metabolism +Glutamine/*metabolism +Gyrus Cinguli/*drug effects/metabolism +Humans +Magnetic Resonance Spectroscopy +Male +Middle Aged +Occipital Lobe/*drug effects/metabolism +gamma-Aminobutyric Acid/metabolism}, + ISSN = {0033-3158 (Print) +0033-3158 (Linking)}, + DOI = {10.1007/s00213-006-0451-y}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16944105}, + year = {2006}, + type = {Journal Article} +} + +@article{RN537, + author = {Moore, C. M. and Wardrop, M. and Frederick, B. D. and Renshaw, P. F.}, + title = {Topiramate raises anterior cingulate cortex glutamine levels in healthy men; a 4.0 T magnetic resonance spectroscopy study}, + journal = {Psychopharmacology}, + volume = {188}, + number = {2}, + pages = {236-243}, + note = {Moore, Constance M. Wardrop, Megan Frederick, Blaise deB. Renshaw, Perry F.}, + abstract = {Rationale Potential mechanisms of action of topiramate include alterations of glutamatergic and GABAergic systems. In particular, topiramate has been shown to increase occipital cortex GABA levels, as measured using proton magnetic resonance spectroscopy (MRS). Objectives The purpose of this study was to measure the effect of acute oral topiramate on the GABA precursors glutamate and glutamine in the anterior cingulate cortex (ACC) and occipital lobe (OL) using high-field (4.0 T) proton MRS ((1)H MRS). Methods Proton MR spectra were acquired from healthy men at three times: at baseline and 2 and 6 h after ingesting 50 (N=5) or 100 mg (N=5) of topiramate. Blood samples were acquired prior to each scan for the purpose of obtaining serum topiramate levels. Results A 100-mg dose of topiramate significantly increased ACC glutamine levels within 2 h of ingestion and OL glutamine levels within 6 h of ingestion. There were no measured significant effects of topiramate on ACC or OL glutamate levels. Conclusions A 100-mg dose of oral topiramate increased serum topiramate and ACC glutamine levels within 2 h. OL glutamine levels increased within 6 h. Increased brain glutamine levels may be a consequence of topiramate positively modulating GABA(A) receptors. This result is of interest given the possible role for topiramate in the treatment of epilepsy, migraine headache, bipolar disorder, eating disorders, and alcohol dependence.}, + ISSN = {0033-3158}, + DOI = {10.1007/s00213-006-0451-y}, + url = {://WOS:000240380000011}, + year = {2006}, + type = {Journal Article} +} + +@article{RN548, + author = {Moore, C. M. and Wardrop, M. and Frederick, B. D. and Renshaw, P. F.}, + title = {Topiramate raises anterior cingulate cortex glutamine levels in healthy men; a 4.0 T magnetic resonance spectroscopy study (vol 188, pg 236, 2006)}, + journal = {Psychopharmacology}, + volume = {190}, + number = {3}, + pages = {401-402}, + note = {Moore, Constance M. Wardrop, Megan Frederick, Blaise deB. Renshaw, Perry F.}, + ISSN = {0033-3158}, + DOI = {10.1007/s00213-006-0617-7}, + url = {://WOS:000243661700010}, + year = {2007}, + type = {Journal Article} +} + +@article{RN553, + author = {Mujica-Parodi, L. R. and Strey, H. H. and Frederick, B. and Savoy, R. and Cox, D. and Botanov, Y. and Tolkunov, D. and Rubin, D. and Weber, J.}, + title = {Chemosensory Cues to Conspecific Emotional Stress Activate Amygdala in Humans}, + journal = {Plos One}, + volume = {4}, + number = {7}, + note = {Mujica-Parodi, Lilianne R. Strey, Helmut H. Frederick, Blaise Savoy, Robert Cox, David Botanov, Yevgeny Tolkunov, Denis Rubin, Denis Weber, Jochen}, + abstract = {Alarm substances are airborne chemical signals, released by an individual into the environment, which communicate emotional stress between conspecifics. Here we tested whether humans, like other mammals, are able to detect emotional stress in others by chemosensory cues. Sweat samples collected from individuals undergoing an acute emotional stressor, with exercise as a control, were pooled and presented to a separate group of participants ( blind to condition) during four experiments. In an fMRI experiment and its replication, we showed that scanned participants showed amygdala activation in response to samples obtained from donors undergoing an emotional, but not physical, stressor. An odor-discrimination experiment suggested the effect was primarily due to emotional, and not odor, differences between the two stimuli. A fourth experiment investigated behavioral effects, demonstrating that stress samples sharpened emotion-perception of ambiguous facial stimuli. Together, our findings suggest human chemosensory signaling of emotional stress, with neurobiological and behavioral effects.}, + ISSN = {1932-6203}, + DOI = {10.1371/journal.pone.0006415}, + url = {://WOS:000268494500016}, + year = {2009}, + type = {Journal Article} +} + +@article{RN3659, + author = {Mujica-Parodi, L. R. and Strey, H. H. and Frederick, B. and Savoy, R. and Cox, D. and Botanov, Y. and Tolkunov, D. and Rubin, D. and Weber, J.}, + title = {Chemosensory cues to conspecific emotional stress activate amygdala in humans}, + journal = {PLoS One}, + volume = {4}, + number = {7}, + pages = {e6415}, + note = {Mujica-Parodi, Lilianne R +Strey, Helmut H +Frederick, Blaise +Savoy, Robert +Cox, David +Botanov, Yevgeny +Tolkunov, Denis +Rubin, Denis +Weber, Jochen +eng +M01 RR010710/RR/NCRR NIH HHS/ +5-M01-RR-10710/RR/NCRR NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, U.S. Gov't, Non-P.H.S. +PLoS One. 2009 Jul 29;4(7):e6415. doi: 10.1371/journal.pone.0006415.}, + abstract = {Alarm substances are airborne chemical signals, released by an individual into the environment, which communicate emotional stress between conspecifics. Here we tested whether humans, like other mammals, are able to detect emotional stress in others by chemosensory cues. Sweat samples collected from individuals undergoing an acute emotional stressor, with exercise as a control, were pooled and presented to a separate group of participants (blind to condition) during four experiments. In an fMRI experiment and its replication, we showed that scanned participants showed amygdala activation in response to samples obtained from donors undergoing an emotional, but not physical, stressor. An odor-discrimination experiment suggested the effect was primarily due to emotional, and not odor, differences between the two stimuli. A fourth experiment investigated behavioral effects, demonstrating that stress samples sharpened emotion-perception of ambiguous facial stimuli. Together, our findings suggest human chemosensory signaling of emotional stress, with neurobiological and behavioral effects.}, + keywords = {Amygdala/*physiology +*Emotions +Humans +Magnetic Resonance Imaging +*Stress, Psychological}, + ISSN = {1932-6203 (Electronic) +1932-6203 (Linking)}, + DOI = {10.1371/journal.pone.0006415}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/19641623}, + year = {2009}, + type = {Journal Article} +} + +@article{RN549, + author = {Negus, S. S. and Frederick, B. D. and Brimson, M. and McWilliams, S. B. and Bear, A. and Meltzer, D. and Kaufman, M. J.}, + title = {fMRI of mu and kappa opioid agonists in non-human primates}, + journal = {Neuropsychopharmacology}, + volume = {31}, + pages = {S216-S217}, + note = {Negus, S. S. Frederick, Blaise D. Brimson, Melanie McWilliams, Samuel B. Bear, Ashley Meltzer, Daniel Kaufman, Marc J. +45th Annual Meeting of the American-College-of-Neuropsychopharmacolgy +DEC 03-07, 2006 +Hollywood, FL +Amer Coll Neuropsychopharmacol +1}, + ISSN = {0893-133X}, + url = {://WOS:000242215900573}, + year = {2006}, + type = {Journal Article} +} + +@article{RN502, + author = {Nickerson, L. D. and Henry, M. E. and Renshaw, P. F. and Frederick, B. B.}, + title = {Analysis of fMRI CBV data using SSM/PCA to investigate functional brain networks: Application in a mood disorder study}, + journal = {Biological Psychiatry}, + volume = {51}, + number = {8}, + pages = {89S-89S}, + note = {Times Cited: 0 +S}, + url = {://WOS:000174980400255}, + year = {2002}, + type = {Journal Article} +} + +@article{RN511, + author = {Pearlson, G. D. and Calhoun, V. D. and Rauch, S. L. and Frederick, B. D. B. and Van Horn, J. D. and Saykin, A. J.}, + title = {Novel means for designing, analyzing and interpreting functional MRI studies}, + journal = {Biological Psychiatry}, + volume = {51}, + number = {8}, + pages = {94S-94S}, + note = {ISI Document Delivery No.: 541JA +Times Cited: 0 +Cited Reference Count: 0 +Pearlson, GD Calhoun, VD Rauch, SL Frederick, BDB Van Horn, JD Saykin, AJ +ELSEVIER SCIENCE INC +NEW YORK +S}, + ISSN = {0006-3223}, + url = {://WOS:000174980400266}, + year = {2002}, + type = {Journal Article} +} + +@article{RN3666, + author = {Prescot, A. P. and de, B. Frederick B. and Wang, L. and Brown, J. and Jensen, J. E. and Kaufman, M. J. and Renshaw, P. F.}, + title = {In vivo detection of brain glycine with echo-time-averaged (1)H magnetic resonance spectroscopy at 4.0 T}, + journal = {Magn Reson Med}, + volume = {55}, + number = {3}, + pages = {681-6}, + note = {Prescot, Andrew P +de B Frederick, Blaise +Wang, Liqun +Brown, John +Jensen, J Eric +Kaufman, Marc J +Renshaw, Perry F +eng +DA014178/DA/NIDA NIH HHS/ +DA017324/DA/NIDA NIH HHS/ +DA14013/DA/NIDA NIH HHS/ +DA15116/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +Magn Reson Med. 2006 Mar;55(3):681-6. doi: 10.1002/mrm.20807.}, + abstract = {A single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) method is described that enables the in vivo measurement of endogenous brain glycine (Gly) levels in human subjects. At 4.0 T, TE-averaging (1)H-MRS dramatically attenuates the overlapping myo-inositol (mI) resonances at 3.52 ppm, permitting a more reliable measure of the Gly singlet peak. This methodology initially is described and tested in phantoms. The phantom data infers that the 3.55-ppm peak predominantly is Gly with a smaller contribution from mI. The composite resonance thus is differentiated from pure Gly and mI and is labeled Gly*. The mI contribution was calculated as <2% of the total Gly* signal for a 1:1 mI/Gly mixture. The technique subsequently was used to acquire TE-averaged (1)H-MRS data from the occipital cortex of healthy control subjects. The resultant spectra closely resembled experimental phantom data. LC-model analysis provided a means for quantifying TE-averaged (1)H-MRS spectra and a mean test-retest variability measure of 15% was established for brain Gly* levels in studies of six healthy subjects.}, + keywords = {Adult +*Brain Chemistry +Female +Glycine/*analysis +Humans +Magnetic Resonance Spectroscopy/*methods +Male}, + ISSN = {0740-3194 (Print) +0740-3194 (Linking)}, + DOI = {10.1002/mrm.20807}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16453318}, + year = {2006}, + type = {Journal Article} +} + +@article{RN518, + author = {Renshaw, P. F. and Babb, S. M. and Wald, L. L. and Moore, C. M. and Frederick, B. D. and Yurgelun-Todd, D. A. and Satlin, A. and Cohen, B. M.}, + title = {Pharmacologic studies of brain phospholipid metabolism using MRS}, + journal = {Biological Psychiatry}, + volume = {43}, + pages = {7S-7S}, + note = {Renshaw, PF Babb, SM Wald, LL Moore, CM Frederick, BD Yurgelun-Todd, DA Satlin, A Cohen, BM +8}, + ISSN = {0006-3223}, + DOI = {10.1016/s0006-3223(98)90470-x}, + url = {://WOS:000073240700024}, + year = {1998}, + type = {Journal Article} +} + +@article{RN521, + author = {Renshaw, P. F. and Parow, A. M. and Hirashima, F. and Ke, Y. and Moore, C. M. and Frederick, B. D. and Fava, M. and Hennen, J. and Cohen, B. M.}, + title = {Multinuclear magnetic resonance spectroscopy studies of brain purines in major depression}, + journal = {American Journal of Psychiatry}, + volume = {158}, + number = {12}, + pages = {2048-2055}, + note = {Renshaw, PF Parow, AM Hirashima, F Ke, Y Moore, CM Frederick, BD Fava, M Hennen, J Cohen, BM +8th Annual Meeting of the International-Society-for-Magnetic-Resonance-in-Medicine +APR 01-07, 2000 +DENVER, COLORADO +Int Soc Magnet Resonance Med}, + abstract = {Objective: Studies of depressed adults have shown abnormalities in cerebral energy metabolism, as noted by low brain levels of nucleoside triphosphate (NTP), which primarily represents adenosine triphosphate (ATP). This study was undertaken to determine whether proton magnetic resonance spectroscopy (H-1 MRS) measures of the low-field purine resonance, which arises primarily from adenosine phosphates, can be used to assess abnormalities in cerebral purine metabolism in depressed adults. Method: Data from H-1 MRS and phosphorus-31 (P-31) MRS were acquired for depressed and nondepressed comparison subjects. Intensities of the purine resonance, by H-1 MRS (7.5-8.5 ppm), and of NTP by P-31 MRS, were determined. Results: Purine resonance intensities did not differ on average between depressed patients and comparison subjects. However, purine levels were approximately 30% lower in female depressed subjects who subsequently responded to fluoxetine treatment than in those who did not respond. Beta-NTP was lower by 21% in responders than in nonresponders and was correlated with purine levels for the depressed subjects. Conclusions: Brain purine levels are low in female depressed patients who respond to treatment with fluoxetine, suggesting that response to treatment might be predicted by using H-1 MRS. These observations also suggest that agents that increase brain adenosine levels may have antidepressant efficacy.}, + ISSN = {0002-953X}, + DOI = {10.1176/appi.ajp.158.12.2048}, + url = {://WOS:000172452100018}, + year = {2001}, + type = {Journal Article} +} + +@article{RN598, + author = {Sassaroli, A and Tong, Y and Frederick, B and Renshaw, P}, + title = {Calculations of BOLD signals by use of NIRS photon migration hitting density functions}, + journal = {Biomedical Optics}, + abstract = {» View Full Text: Acrobat PDF (101 KB) * * Note that full-text PDFs from conferences typically contain 1-3 pages of content, some or all of which might be an abstract, summary, or miscellaneous items.}, + year = {2006}, + type = {Journal Article} +} + +@article{RN3665, + author = {Sassaroli, A. and de, B. Frederick B. and Tong, Y. and Renshaw, P. F. and Fantini, S.}, + title = {Spatially weighted BOLD signal for comparison of functional magnetic resonance imaging and near-infrared imaging of the brain}, + journal = {Neuroimage}, + volume = {33}, + number = {2}, + pages = {505-14}, + note = {Sassaroli, Angelo +deB Frederick, Blaise +Tong, Yunjie +Renshaw, Perry F +Fantini, Sergio +eng +DA14178/DA/NIDA NIH HHS/ +K25DA14013/DA/NIDA NIH HHS/ +Comparative Study +Research Support, N.I.H., Extramural +Research Support, U.S. Gov't, Non-P.H.S. +Neuroimage. 2006 Nov 1;33(2):505-14. doi: 10.1016/j.neuroimage.2006.07.006. Epub 2006 Aug 30.}, + abstract = {We introduce a weighted spatial average of the functional magnetic resonance imaging (fMRI) BOLD signal (blood oxygen level-dependent) that is appropriate for comparison with the changes in oxy- and deoxy-hemoglobin concentrations measured with near-infrared spectroscopy (NIRS) during brain activation. Because the BOLD signal shows a spatial dependence (both in shape and amplitude) within the region of activation, the location of the optical probe with respect to the region of BOLD activation should be taken into account for comparison of the BOLD and NIRS signals. Our new method is based on combining weighted contributions of the BOLD signal from each activated voxel, with a weight given by a hitting density function for photons migrating between a given pair of illumination and collection points. We present a case study where we have found that the new spatially weighted BOLD signal shows a high spatial and temporal correlation with the oxy- and deoxy-hemoglobin concentration changes measured with NIRS during a hand-tapping protocol. These findings reinforce the idea that fMRI and NIRS are sensitive to similar underlying hemodynamic changes, and indicate that the proposed weighted BOLD signal is needed for a quantitative comparison of BOLD and NIRS signals.}, + keywords = {Brain/*anatomy & histology +*Brain Mapping +Cerebrovascular Circulation +Functional Laterality +Hand/innervation +Humans +Magnetic Resonance Imaging/*methods +Oxygen/blood +Photons +Spectrophotometry, Infrared/methods}, + ISSN = {1053-8119 (Print) +1053-8119 (Linking)}, + DOI = {10.1016/j.neuroimage.2006.07.006}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16945553}, + year = {2006}, + type = {Journal Article} +} + +@article{RN510, + author = {Sassaroli, A. and Frederick, B. D. and Tong, Y. J. and Renshaw, P. F. and Fantini, S.}, + title = {Spatially weighted BOLD signal for comparison of functional magnetic resonance imaging and near-infrared imaging of the brain}, + journal = {Neuroimage}, + volume = {33}, + number = {2}, + pages = {505-514}, + note = {Sassaroli, Angelo Frederick, Blaise deB. Tong, Yunjie Renshaw, Perry F. Fantini, Sergio}, + abstract = {We introduce a weighted spatial average of the functional magnetic resonance imaging (fMRI) BOLD signal (blood oxygen level-dependent) that is appropriate for comparison with the changes in oxy- and deoxy-hemoglobin concentrations measured with near-infrared spectroscopy (NIRS) during brain activation. Because the BOLD signal shows a spatial dependence (both in shape and amplitude) within the region of activation, the location of the optical probe with respect to the region of BOLD activation should be taken into account for comparison of the BOLD and NIRS signals. Our new method is based on combining weighted contributions of the BOLD signal from each activated voxel, with a weight given by a hitting density function for photons migrating between a given pair of illumination and collection points. We present a case study where we have found that the new spatially weighted BOLD signal shows a high spatial and temporal correlation with the oxy- and deoxy-hemoglobin concentration changes measured with NIRS during a hand-tapping protocol. These findings reinforce the idea that fMRI and NIRS are sensitive to similar underlying hemodynamic changes, and indicate that the proposed weighted BOLD signal is needed for a quantitative comparison of BOLD and NIRS signals. (c) 2006 Elsevier Inc. All rights reserved.}, + ISSN = {1053-8119}, + DOI = {10.1016/j.neuroimage.2006.07.006}, + url = {://WOS:000241406800008}, + year = {2006}, + type = {Journal Article} +} + +@article{RN499, + author = {Savoy, R. L. and Frederick, B. B. and Keuroghlian, A. S. and Wolk, P. C.}, + title = {Voluntary switching between identities in dissociative identity disorder: A functional MRI case study}, + journal = {Cognitive Neuroscience}, + volume = {3}, + number = {2}, + pages = {112-119}, + note = {Times Cited: 0}, + abstract = {Patients who suffer from dissociative identity disorder present unique scientific and clinical challenges for psychology and psychiatry. We have been fortunate in working with a patient who-while undergoing functional MRI-can switch rapidly and voluntarily between her main personality (a middle-aged, high-functioning woman) and an alternate personality (a 4-6-year-old girl). A unique task was designed to isolate the processes occurring during the switches between these personalities. Data are from two imaging sessions, conducted months apart, each showing the same activated areas during switches between these personalities. The activated areas include the following: the primary sensory and motor cortex, likely associated with characteristic facial movements made during switching; the nucleus accumbens bilaterally, possibly associated with aspects of reward connected with switching; and prefrontal sites, presumably associated with the executive control involved in the switching of personalities.}, + DOI = {10.1080/17588928.2012.669750}, + url = {://WOS:000305028800007}, + year = {2012}, + type = {Journal Article} +} + +@article{RN3646, + author = {Savoy, R. L. and Frederick, B. B. and Keuroghlian, A. S. and Wolk, P. C.}, + title = {Voluntary switching between identities in dissociative identity disorder: A functional MRI case study}, + journal = {Cogn Neurosci}, + volume = {3}, + number = {2}, + pages = {112-9}, + note = {Savoy, R L +Frederick, B B +Keuroghlian, A S +Wolk, P C +eng +England +Cogn Neurosci. 2012;3(2):112-9. doi: 10.1080/17588928.2012.669750. Epub 2012 Mar 23.}, + abstract = {Patients who suffer from dissociative identity disorder present unique scientific and clinical challenges for psychology and psychiatry. We have been fortunate in working with a patient who-while undergoing functional MRI-can switch rapidly and voluntarily between her main personality (a middle-aged, high-functioning woman) and an alternate personality (a 4-6-year-old girl). A unique task was designed to isolate the processes occurring during the switches between these personalities. Data are from two imaging sessions, conducted months apart, each showing the same activated areas during switches between these personalities. The activated areas include the following: the primary sensory and motor cortex, likely associated with characteristic facial movements made during switching; the nucleus accumbens bilaterally, possibly associated with aspects of reward connected with switching; and prefrontal sites, presumably associated with the executive control involved in the switching of personalities.}, + ISSN = {1758-8936 (Electronic) +1758-8928 (Linking)}, + DOI = {10.1080/17588928.2012.669750}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/24168692}, + year = {2012}, + type = {Journal Article} +} + +@article{RN538, + author = {Schneider, E. and Bolo, N. R. and Frederick, B. and Wilkinson, S. and Hirashima, F. and Nassar, L. and Lyoo, I. K. and Koch, P. and Jones, S. and Hwang, J. and Sung, Y. and Villafuerte, R. A. and Maier, G. and Hsu, R. and Hashoian, R. and Renshaw, P. F.}, + title = {Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole}, + journal = {Journal of Clinical Pharmacy and Therapeutics}, + volume = {31}, + number = {3}, + pages = {261-273}, + note = {Schneider, E Bolo, NR Frederick, B Wilkinson, S Hirashima, F Nassar, L Lyoo, IK Koch, P Jones, S Hwang, J Sung, Y Villafuerte, RA Maier, G Hsu, R Hashoian, R Renshaw, PF}, + abstract = {Background and objective: The study of biodistribution and in situ pharmacokinetics is a challenging, but sometimes very important, aspect of premarketing characterization of drugs. We aimed to develop a non-invasive fluorine magnetic resonance (MR) spectroscopic method for the absolute quantitation of a mono-fluorinated compound and of its metabolites in the heart and liver of healthy subjects for this purpose. Method: We used fluorine MR spectroscopy (MRS) at 4 T (Tesla) and external standardization in an open label multiple-dose study. Twenty-three healthy adult subjects were enrolled in the study. The surface coil localized fluorine MR spectrum was monitored in the heart and liver at baseline and after oral administration of multiple doses of tecastemizole. Steady-state measurements were made at set time points that depended upon dose, and washout measurements were made only on subjects in which in vivo fluorine signal was observed. Results and discussion: At 4 T, under the given experimental conditions, the method had a lower limit of quantitation (LLOQ) of about 2.6 mu M and a limit of detection (LOD) of about 0.3 mu M for solution state samples (linewidth approximately 15 Hz). The measurement reproducibility was 6.4% using a 50 mu M phantom. The effect of MR operator and spectral analyst on the calculated calibration curve slope was small, with inter-rater correlation coefficients of 0.999 and 0.998 respectively. MR signal from fluorine-containing tecastemizole-related moieties was observed in situ only at day 8 in the liver of three of five subjects dosed at 270 mg/day. The average in situ concentration was estimated to be 58 +/- 22 mu M, with an average test-retest reproducibility of 216%. Extrapolating the in vitro results to human measurements, with an approximate linewidth of 250 Hz, predicts in situ LOD and LLOQ values of approximately 6 and 44 mu M respectively. However, the human study had a fluorine MRS LOD of approximately 20 mu M. The decrease in sensitivity and the increase in variability of the in vivo, in situ measurements compared with the validation study most likely arose from coil placement and incomplete rephasing of the MR signal by the respiratory phase compensation method. Conclusion: The measured concentrations were the lowest ever recorded for a multi-dose exogenous mono-fluorinated compound in the human liver using a validated fluorine MR quantitation method. The proposed non-invasive MR method for studying the biodistribution and in situ pharmacokinetics of mono-fluorinated compounds in the liver and heart should have broader application to the development of non-invasive biomarkers.}, + ISSN = {0269-4727}, + DOI = {10.1111/j.1365-2710.2006.00735.x}, + url = {://WOS:000238065300008}, + year = {2006}, + type = {Journal Article} +} + +@article{RN3663, + author = {Schneider, E. and Bolo, N. R. and Frederick, B. and Wilkinson, S. and Hirashima, F. and Nassar, L. and Lyoo, I. K. and Koch, P. and Jones, S. and Hwang, J. and Sung, Y. and Villafuerte, R. A. and Maier, G. and Hsu, R. and Hashoian, R. and Renshaw, P. F.}, + title = {Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole}, + journal = {J Clin Pharm Ther}, + volume = {31}, + number = {3}, + pages = {261-73}, + note = {Schneider, E +Bolo, N R +Frederick, B +Wilkinson, S +Hirashima, F +Nassar, L +Lyoo, I K +Koch, P +Jones, S +Hwang, J +Sung, Y +Villafuerte, R A +Maier, G +Hsu, R +Hashoian, R +Renshaw, P F +eng +DA14013/DA/NIDA NIH HHS/ +DA14178/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +England +J Clin Pharm Ther. 2006 Jun;31(3):261-73. doi: 10.1111/j.1365-2710.2006.00735.x.}, + abstract = {BACKGROUND AND OBJECTIVE: The study of biodistribution and in situ pharmacokinetics is a challenging, but sometimes very important, aspect of premarketing characterization of drugs. We aimed to develop a non-invasive fluorine magnetic resonance (MR) spectroscopic method for the absolute quantitation of a mono-fluorinated compound and of its metabolites in the heart and liver of healthy subjects for this purpose. METHOD: We used fluorine MR spectroscopy (MRS) at 4 T (Tesla) and external standardization in an open label multiple-dose study. Twenty-three healthy adult subjects were enrolled in the study. The surface coil localized fluorine MR spectrum was monitored in the heart and liver at baseline and after oral administration of multiple doses of tecastemizole. Steady-state measurements were made at set time points that depended upon dose, and washout measurements were made only on subjects in which in vivo fluorine signal was observed. RESULTS AND DISCUSSION: At 4 T, under the given experimental conditions, the method had a lower limit of quantitation (LLOQ) of about 2.6 microm and a limit of detection (LOD) of about 0.3 microm for solution state samples (linewidth approximately 15 Hz). The measurement reproducibility was 6.4% using a 50 microm phantom. The effect of MR operator and spectral analyst on the calculated calibration curve slope was small, with inter-rater correlation coefficients of 0.999 and 0.998 respectively. MR signal from fluorine-containing tecastemizole-related moieties was observed in situ only at day 8 in the liver of three of five subjects dosed at 270 mg/day. The average in situ concentration was estimated to be 58+/-22 microm, with an average test-retest reproducibility of 216%. Extrapolating the in vitro results to human measurements, with an approximate linewidth of 250 Hz, predicts in situ LOD and LLOQ values of approximately 6 and 44 microm respectively. However, the human study had a fluorine MRS LOD of approximately 20 microm. The decrease in sensitivity and the increase in variability of the in vivo, in situ measurements compared with the validation study most likely arose from coil placement and incomplete rephasing of the MR signal by the respiratory phase compensation method. CONCLUSION: The measured concentrations were the lowest ever recorded for a multi-dose exogenous mono-fluorinated compound in the human liver using a validated fluorine MR quantitation method. The proposed non-invasive MR method for studying the biodistribution and in situ pharmacokinetics of mono-fluorinated compounds in the liver and heart should have broader application to the development of non-invasive biomarkers.}, + keywords = {Adult +Animals +Anti-Allergic Agents/*pharmacokinetics +Benzimidazoles/*pharmacokinetics +Chromatography, High Pressure Liquid +Dogs +Dose-Response Relationship, Drug +Echo-Planar Imaging +Female +Fluorine Compounds/*pharmacokinetics +Fluorine Radioisotopes +Half-Life +Humans +Liver/*metabolism +Magnetic Resonance Spectroscopy +Male +Middle Aged +Myocardium/*metabolism +Piperidines/*pharmacokinetics +Reproducibility of Results +Tissue Distribution}, + ISSN = {0269-4727 (Print) +0269-4727 (Linking)}, + DOI = {10.1111/j.1365-2710.2006.00735.x}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16789992}, + year = {2006}, + type = {Journal Article} +} + +@article{RN558, + author = {Streeter, C. C. and Frederick, B. D. and Rohsenow, D. J. and Howland, J.}, + title = {COMPENSATORY RECRUITMENT OF PREFRONTAL CORTEX DURING CORRECT RESPONSES IN A CONTINUOUS PERFORMANCE TASK DURING A HANGOVER CONDITION COMPARED TO A PLACEBO CONDITION}, + journal = {Alcoholism-Clinical and Experimental Research}, + volume = {34}, + number = {8}, + pages = {61A-61A}, + note = {Streeter, C. C. Frederick, B. de B. Rohsenow, D. J. Howland, J. +World Congress on International-Society-for-Biomedical-Research-on-Alcoholism +SEP 13-16, 2010 +Paris, FRANCE +Int Soc Biomed Res Alcoholism, Soc Francaise Alcoolog +S}, + ISSN = {0145-6008}, + url = {://WOS:000280252600188}, + year = {2010}, + type = {Journal Article} +} + +@article{RN497, + author = {Streeter, C. C. and Woodward, S. H. and Kaloupek, D. G. and Wald, L. L. and Tian, H. and Kwak, T. and Lane, B. and Frederick, B. B. and Stegman, W. K. and Kutter, C. J. and Stewart, L. P. and Prestel, R. S. and Renshaw, P. F.}, + title = {Hippocampal volumes in PTSD with and without alcohol dependence}, + journal = {Alcoholism-Clinical and Experimental Research}, + volume = {28}, + number = {5}, + pages = {20A-20A}, + note = {Times Cited: 0 +S +27th Annual Meeting of the Research-Society-on-Alcoholism +JUN 26-30, 2004 +Vancouver, CANADA +Res Soc Alcoholism}, + url = {://WOS:000221549300081}, + year = {2004}, + type = {Journal Article} +} + +@article{RN3650, + author = {Tong, Y. and Bergethon, P. R. and Frederick, B. D.}, + title = {An improved method for mapping cerebrovascular reserve using concurrent fMRI and near-infrared spectroscopy with Regressor Interpolation at Progressive Time Delays (RIPTiDe)}, + journal = {Neuroimage}, + volume = {56}, + number = {4}, + pages = {2047-57}, + note = {Tong, Yunjie +Bergethon, Peter R +Frederick, Blaise Deb +eng +R21 DA021817/DA/NIDA NIH HHS/ +R21 DA021817-02/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +R21-DA021817/DA/NIDA NIH HHS/ +R01 NS059933/NS/NINDS NIH HHS/ +R21-DA027877/DA/NIDA NIH HHS/ +R01 NS059933-04/NS/NINDS NIH HHS/ +R21 DA027877-01A1/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Neuroimage. 2011 Jun 15;56(4):2047-57. doi: 10.1016/j.neuroimage.2011.03.071. Epub 2011 Apr 1.}, + abstract = {Cerebrovascular reserve (CVR) reflects the compensatory dilatory capacity of cerebral vasculature to a dilatory stimulus. Blood oxygen-level dependent (BOLD) fMRI has been proven to be an effective imaging technique to obtain CVR maps when subjects perform CO(2) inhalation or a breath-holding (BH) task. Here we propose a novel way to process the fMRI data obtained during a blocked BH task by using simultaneously collected near-infrared spectroscopy (NIRS) data as regressors to estimate the vascular contribution to the BOLD signal. Six healthy subjects underwent a 6min 30s resting state (RS) fMRI scan, followed by a scan of the same duration with a blocked BH task (5 breath holds with 20s durations separated by ~50s of regular breathing). NIRS data were recorded from a probe over the subjects' right prefrontal area. For each scan, the time course of changes in total hemoglobin (Delta[tHb]) was calculated from the NIRS data, time shifted by various amounts, and resampled to the fMRI acquisition rate. Each shifted time course was used as regressor in a general linear model analysis. The maximum parameter estimate across all time shifts was calculated at all voxels in both the BH and RS scans, and then converted into signal percentage changes. The ratio of these signal changes generates a CVR map of the BH response, normalized to the resting state. The NIRS regressor method makes no assumptions about the shape (or presence) of the BH response, and allows direct, quantitative comparison of the vascular BOLD response to BH to the baseline map obtained in the resting state.}, + keywords = {Adult +Brain/*blood supply +Brain Mapping/*methods +Cerebrovascular Circulation/*physiology +Female +Humans +Image Interpretation, Computer-Assisted/methods +Magnetic Resonance Imaging/*methods +Male +Oxygen/blood +Spectroscopy, Near-Infrared/*methods}, + ISSN = {1095-9572 (Electronic) +1053-8119 (Linking)}, + DOI = {10.1016/j.neuroimage.2011.03.071}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/21459147}, + year = {2011}, + type = {Journal Article} +} + +@article{RN1408, + author = {Tong, Y. and Frederick, B. D.}, + title = {Time lag dependent multimodal processing of concurrent fMRI and near-infrared spectroscopy (NIRS) data suggests a global circulatory origin for low-frequency oscillation signals in human brain}, + journal = {Neuroimage}, + volume = {53}, + number = {2}, + pages = {553-64}, + note = {Tong, Yunjie +Frederick, Blaise Deb +eng +R21 DA021817/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +R21-DA021817/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Neuroimage. 2010 Nov 1;53(2):553-64. doi: 10.1016/j.neuroimage.2010.06.049. Epub 2010 Jun 28.}, + abstract = {Low frequency oscillations (LFOs), characterized by frequencies in the range 0.01-0.1 Hz are commonly observed in blood-related brain functional measurements such as near-infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI). While their physiological origin and implications are not fully understood, these signals are believed to reflect some types of neuronal signaling, systemic hemodynamics, and/or cerebral vascular auto-regulation processes. Here, we examine a new method of integrated processing of concurrent NIRS and fMRI data collected on six human subjects during a whole brain resting state acquisition. The method combines the high spatial resolution offered by fMRI (approximately 3mm) and the high temporal resolution offered by NIRS (approximately 80 ms) to allow for the quantitative assessment of temporal relationships between the LFOs observed at different spatial locations in fMRI data. This temporal relationship allowed us to infer that the origin of a large proportion of the LFOs is independent of the baseline neural activity. The spatio-temporal pattern of LFOs detected by NIRS and fMRI evolves temporally through the brain in a way that resembles cerebral blood flow dynamics. Our results suggest that a major component of the LFOs arise from fluctuations in the blood flow and hemoglobin oxygenation at a global circulatory system level.}, + keywords = {Adult +Brain/*anatomy & histology/physiology +Cerebrovascular Circulation/*physiology +Female +Heart Rate/physiology +Hemodynamics +Hemoglobins/metabolism +Humans +Image Processing, Computer-Assisted/*methods +Magnetic Resonance Imaging/*methods +Male +Models, Statistical +Oximetry +Oxygen/blood +Spectroscopy, Near-Infrared/*methods}, + ISSN = {1095-9572 (Electronic) +1053-8119 (Linking)}, + DOI = {10.1016/j.neuroimage.2010.06.049}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/20600975}, + year = {2010}, + type = {Journal Article} +} + +@article{RN1470, + author = {Tong, Y. and Frederick, B. D.}, + title = {Studying the Spatial Distribution of Physiological Effects on BOLD Signals Using Ultrafast fMRI}, + journal = {Front Hum Neurosci}, + volume = {8}, + number = {196}, + pages = {196}, + note = {Tong, Yunjie +Frederick, Blaise Deb +eng +K25 DA031769/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +Switzerland +Front Hum Neurosci. 2014 Apr 1;8:196. doi: 10.3389/fnhum.2014.00196. eCollection 2014.}, + abstract = {The blood-oxygen-level dependent (BOLD) signal in functional MRI (fMRI) reflects both neuronal activations and global physiological fluctuations. These physiological fluctuations can be attributed to physiological low frequency oscillations (pLFOs), respiration, and cardiac pulsation. With typical TR values, i.e., 2 s or longer, the high frequency physiological signals (i.e., from respiration and cardiac pulsation) are aliased into the low frequency band, making it hard to study the individual effect of these physiological processes on BOLD. Recently developed multiband EPI sequences, which offer full brain coverage with extremely short TR values (400 ms or less) allow these physiological signals to be spectrally separated. In this study, we applied multiband resting state scans on nine healthy participants with TR = 0.4 s. The spatial distribution of each physiological process on BOLD fMRI was explored using their spectral features and independent component analysis (ICA). We found that the spatial distributions of different physiological processes are distinct. First, cardiac pulsation affects mostly the base of the brain, where high density of arteries exists. Second, respiration affects prefrontal and occipital areas, suggesting the motion associated with breathing might contribute to the noise. Finally, and most importantly, we found that the effects of pLFOs dominated many prominent ICA components, which suggests that, contrary to the popular belief that aliased cardiac and respiration signals are the main physiological noise source in BOLD fMRI, pLFOs may be the most influential physiological signals. Understanding and measuring these pLFOs are important for denoising and accurately modeling BOLD signals.}, + keywords = {BOLD fMRI +independent component analysis +low frequency oscillations +multiband EPI +physiological noise}, + ISSN = {1662-5161 (Print) +1662-5161 (Linking)}, + DOI = {10.3389/fnhum.2014.00196}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/24744722}, + year = {2014}, + type = {Journal Article} +} + +@article{RN3645, + author = {Tong, Y. and Frederick, Bd}, + title = {Concurrent fNIRS and fMRI processing allows independent visualization of the propagation of pressure waves and bulk blood flow in the cerebral vasculature}, + journal = {Neuroimage}, + volume = {61}, + number = {4}, + pages = {1419-27}, + note = {Tong, Yunjie +Frederick, Blaise deB +eng +R21 DA027877-02/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +T32-DA015036-11/DA/NIDA NIH HHS/ +T32 DA015036-11/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +R21-DA027877/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Neuroimage. 2012 Jul 16;61(4):1419-27. doi: 10.1016/j.neuroimage.2012.03.009. Epub 2012 Mar 13.}, + abstract = {Blood Oxygen Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) measures changes in blood oxygenation, which is affected by physiological processes, including cardiac pulsation, breathing, and low frequency oscillations (LFO). It is challenging to identify spatial and temporal effects of these processes on the BOLD signal because the low sampling rate of BOLD leads to aliasing of higher frequency physiological signal components. In this study, we used concurrent functional near infrared spectroscopy (fNIRS) and fMRI on 6 subjects during a resting state scan. To reduce aliasing, the BOLD fMRI acquisition was repeatedly performed on a set of sequentially acquired slice stacks to lower the TR to 0.5s while retaining high spatial resolution. Regressor interpolation at progressive time delays (RIPTiDe) method was used, in which physiological signal acquired by fNIRS (without aliasing) and its temporal shifts were used as regressors in the fMRI analysis to determine the magnitude and timing of the effects of various physiological processes on the BOLD signal. The details of the timing of the passage of the cardiac pulsation wave and of the cerebral blood itself were mapped. The result suggests that the cardiac signal affects the voxels near large blood vessels (arteries and veins) most strongly, while LFO mostly affected the drainage veins. We hypothesize that this could be the result of differences in the cerebral blood path lengths, and differences in the dynamics of the propagation of the signals. Together these results validate and extend a novel imaging technique to dynamically track the pulse-wave and bulk blood flow with concurrent fMRI and fNIRS.}, + keywords = {Adult +Brain/*blood supply/physiology +Brain Mapping/*methods +Cerebrovascular Circulation/*physiology +Female +Hemodynamics/physiology +Humans +Image Interpretation, Computer-Assisted/*methods +Magnetic Resonance Imaging/*methods +Male +Oxygen/blood +Spectroscopy, Near-Infrared/*methods}, + ISSN = {1095-9572 (Electronic) +1053-8119 (Linking)}, + DOI = {10.1016/j.neuroimage.2012.03.009}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/22440649}, + year = {2012}, + type = {Journal Article} +} + +@article{RN566, + author = {Tong, Y. and Frederick, Bd}, + title = {Tracking cerebral blood flow in BOLD fMRI using recursively generated regressors}, + journal = {Hum Brain Mapp}, + volume = {35}, + number = {11}, + pages = {5471-85}, + note = {Tong, Yunjie +Frederick, Blaise deB +eng +K25 DA031769/DA/NIDA NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Hum Brain Mapp. 2014 Nov;35(11):5471-85. doi: 10.1002/hbm.22564. Epub 2014 Jun 23.}, + abstract = {BOLD functional MRI (fMRI) data are dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portions of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong et al. [2013]: NeuroImage 76:202-215). They are commonly treated as physiological noise in fMRI studies. In this study, we propose and test a novel data-driven analytical method that uses these systemic low frequency oscillations in the BOLD signal as a tracer to follow cerebral blood flow dynamically. Our findings demonstrate that: (1) systemic oscillations pervade the BOLD signal; (2) the temporal traces evolve as the blood propagates though the brain; and, (3) they can be effectively extracted via a recursive procedure and used to derive the cerebral circulation map. Moreover, this method is independent from functional analyses, and thus allows simultaneous and independent assessment of information about cerebral blood flow to be conducted in parallel with the functional studies. In this study, the method was applied to data from the resting state scans, acquired using a multiband EPI sequence (fMRI scan with much shorter TRs), of seven healthy participants. Dynamic maps with consistent features resembling cerebral blood circulation were derived, confirming the robustness and repeatability of the method.}, + keywords = {Adolescent +Adult +*Brain Mapping +Cerebral Cortex/*blood supply +Cerebrovascular Circulation/*physiology +Female +Humans +Image Processing, Computer-Assisted +*Magnetic Resonance Imaging +Male +Nonlinear Dynamics +Oxygen/blood +Regression Analysis +Time Factors +Young Adult +BOLD fMRI +cerebral blood flow +low frequency oscillations +recursive procedure}, + ISSN = {1097-0193 (Electronic) +1065-9471 (Linking)}, + DOI = {10.1002/hbm.22564}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/24954380}, + year = {2014}, + type = {Journal Article} +} + +@article{RN3629, + author = {Tong, Y. and Hocke, L. M. and Fan, X. and Janes, A. C. and Frederick, Bd}, + title = {Can apparent resting state connectivity arise from systemic fluctuations?}, + journal = {Front Hum Neurosci}, + volume = {9}, + number = {63}, + pages = {285}, + note = {Tong, Yunjie +Hocke, Lia M +Fan, Xiaoying +Janes, Amy C +Frederick, Blaise deB +eng +K01 DA029645/DA/NIDA NIH HHS/ +K25 DA031769/DA/NIDA NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +Switzerland +Front Hum Neurosci. 2015 May 15;9:285. doi: 10.3389/fnhum.2015.00285. eCollection 2015.}, + abstract = {It is widely accepted that the fluctuations in resting state blood oxygenation level dependent (BOLD) functional MRI (fMRI) reflect baseline neuronal activation through neurovascular coupling; this data is used to infer functional connectivity in the human brain during rest. Consistent activation patterns, i.e., resting state networks (RSN) are seen across groups, conditions, and even species. In this study, we show that some of these patterns can also be generated from the dynamic, systemic, non-neuronal physiological low frequency oscillations (sLFOs) in the BOLD signal alone. We have previously used multimodal imaging to demonstrate the wide presence of the same sLFOs in the brain (BOLD) and periphery with different time delays. This study shows that these sLFOs from BOLD signals alone can give rise to stable spatial patterns, which can be detected during resting state analyses. We generated synthetic resting state data for 11 subjects based only on subject-specific, dynamic sLFO information obtained from resting state data using concurrent peripheral optical imaging or a novel recursive procedure. We compared the results obtained by performing a group independent component analysis (ICA) on this synthetic data (i.e., the result from simulation) to the results obtained from analysis of the real data. ICA detected most of the eight well-known RSNs, including visual, motor, and default mode networks (DMNs), in both the real and the synthetic data sets. These findings suggest that RSNs may reflect, to some extent, vascular anatomy associated with systemic fluctuations, rather than neuronal connectivity.}, + keywords = {BOLD fMRI +cerebral blood flow +resting state networks +slow oscillations +systemic oscillations}, + ISSN = {1662-5161 (Print) +1662-5161 (Linking)}, + DOI = {10.3389/fnhum.2015.00285}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/26029095}, + year = {2015}, + type = {Journal Article} +} + +@article{RN1469, + author = {Tong, Y. and Hocke, L. M. and Frederick, Bd}, + title = {Isolating the sources of widespread physiological fluctuations in functional near-infrared spectroscopy signals}, + journal = {J Biomed Opt}, + volume = {16}, + number = {10}, + pages = {106005}, + note = {Tong, Yunjie +Hocke, Lia Maria +Frederick, Blaise deB +eng +R21 DA027877/DA/NIDA NIH HHS/ +R21DA027877/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +J Biomed Opt. 2011 Oct;16(10):106005. doi: 10.1117/1.3638128.}, + abstract = {Physiological fluctuations at low frequency (<0.1 Hz) are prominent in functional near-infrared spectroscopy (fNIRS) measurements in both resting state and functional task studies. In this study, we used the high spatial resolution and full brain coverage of functional magnetic resonance imaging (fMRI) to understand the origins and commonalities of these fluctuations. Specifically, we applied a newly developed method, regressor interpolation at progressive time delays, to analyze concurrently recorded fNIRS and fMRI data acquired both in a resting state study and in a finger tapping study. The method calculates the voxelwise correlations between blood oxygen level dependent (BOLD) fMRI and fNIRS signals with different time shifts and localizes the areas in the brain that highly correlate with the fNIRS signal recorded at the surface of the head. The results show the wide spatial distribution of this physiological fluctuation in BOLD data, both in task and resting states. The brain areas that are highly correlated with global physiological fluctuations observed by fNIRS have a pattern that resembles the venous system of the brain, indicating the blood fluctuation from veins on the brain surface might strongly contribute to the overall fNIRS signal.}, + keywords = {Adult +Brain/*physiology +Data Interpretation, Statistical +Female +Hemoglobins/metabolism +Humans +Magnetic Resonance Imaging/*statistics & numerical data +Male +Models, Neurological +Optical Phenomena +Oxyhemoglobins/metabolism +Signal Processing, Computer-Assisted +Spectroscopy, Near-Infrared/*statistics & numerical data +Task Performance and Analysis +Young Adult}, + ISSN = {1560-2281 (Electronic) +1083-3668 (Linking)}, + DOI = {10.1117/1.3638128}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/22029352}, + year = {2011}, + type = {Journal Article} +} + +@article{RN3633, + author = {Tong, Y. and Hocke, L. M. and Frederick, Bd}, + title = {Short repetition time multiband echo-planar imaging with simultaneous pulse recording allows dynamic imaging of the cardiac pulsation signal}, + journal = {Magn Reson Med}, + volume = {72}, + number = {5}, + pages = {1268-76}, + note = {Tong, Yunjie +Hocke, Lia M +Frederick, Blaise deB +eng +K25DA031769/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +K25 DA031769/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +R21 DA034766/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Magn Reson Med. 2014 Nov;72(5):1268-76. doi: 10.1002/mrm.25041. Epub 2013 Nov 22.}, + abstract = {PURPOSE: Recently developed simultaneous multislice echo-planar imaging (EPI) sequences permit imaging of the whole brain at short repetition time (TR), allowing the cardiac fluctuations to be fully sampled in blood-oxygen-level dependent functional MRI (BOLD fMRI). A novel low computational analytical method was developed to dynamically map the passage of the pulsation signal through the brain and visualize the whole cerebral vasculature affected by the pulse signal. This algorithm is based on a simple combination of fast BOLD fMRI and the scanner's own built-in pulse oximeter. METHODS: Multiple, temporally shifted copies of the pulse oximeter data (with 0.08 s shifting step and coverage of a 1-s span) were downsampled and used as cardiac pulsation regressors in a general linear model based analyses (FSL) of the fMRI data. The resulting concatenated z-statistics maps show the voxels that are affected as the cardiac signal travels through the brain. RESULTS: Many voxels were highly correlated with the pulsation regressor or its temporally shifted version. The dynamic and static cardiac pulsation maps obtained from both the task and resting state scans, resembled cerebral vasculature. CONCLUSION: The results demonstrated: (i) cardiac pulsation significantly affects most voxels in the brain; (ii) combining fast fMRI and this analytical method can reveal additional clinical information to functional studies.}, + keywords = {Adult +Algorithms +Brain/*blood supply +Brain Mapping/*methods +Echo-Planar Imaging/*methods +Female +Healthy Volunteers +Heart Rate/*physiology +Humans +Image Enhancement/methods +Image Processing, Computer-Assisted/methods +Imaging, Three-Dimensional/methods +Magnetic Resonance Imaging/*methods +Male +Oximetry +BOLD fMRI +cardiac pulsation +cerebral vasculature +correlation analysis +multiband EPI}, + ISSN = {1522-2594 (Electronic) +0740-3194 (Linking)}, + DOI = {10.1002/mrm.25041}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/24272768}, + year = {2014}, + type = {Journal Article} +} + +@article{RN3637, + author = {Tong, Y. and Hocke, L. M. and Licata, S. C. and Frederick, Bd}, + title = {Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signals}, + journal = {J Biomed Opt}, + volume = {17}, + number = {10}, + pages = {106004}, + note = {Tong, Yunjie +Hocke, Lia Maria +Licata, Stephanie C +Frederick, Blaise deB +eng +K01 DA023659/DA/NIDA NIH HHS/ +R03 DA024220/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +J Biomed Opt. 2012 Oct;17(10):106004. doi: 10.1117/1.JBO.17.10.106004.}, + abstract = {Low-frequency oscillations (LFOs) in the range of 0.01-0.15 Hz are commonly observed in functional imaging studies, such as blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) and functional near-infrared spectroscopy (fNIRS). Some of these LFOs are nonneuronal and are closely related to autonomic physiological processes. In the current study, we conducted a concurrent resting-state fMRI and NIRS experiment with healthy volunteers. LFO data was collected simultaneously at peripheral sites (middle fingertip and big toes) by NIRS, and centrally in the brain by BOLD fMRI. The cross-correlations of the LFOs collected from the finger, toes, and brain were calculated. Our data show that the LFOs measured in the periphery (NIRS signals) and in the brain (BOLD fMRI) were strongly correlated with varying time delays. This demonstrates that some portion of the LFOs actually reflect systemic physiological circulatory effects. Furthermore, we demonstrated that NIRS is effective for measuring the peripheral LFOs, and that these LFOs and the temporal shifts between them are consistent in healthy participants and may serve as useful biomarkers for detecting and monitoring circulatory dysfunction.}, + keywords = {Adult +Brain/*blood supply/physiology +Female +Fingers/blood supply +Humans +Magnetic Resonance Imaging/*methods +Male +Oxygen/*blood +Signal Processing, Computer-Assisted +Spectroscopy, Near-Infrared/*methods +Toes/blood supply}, + ISSN = {1560-2281 (Electronic) +1083-3668 (Linking)}, + DOI = {10.1117/1.JBO.17.10.106004}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/23224003}, + year = {2012}, + type = {Journal Article} +} + +@article{RN3626, + author = {Tong, Y. and Hocke, L. M. and Lindsey, K. P. and Erdogan, S. B. and Vitaliano, G. and Caine, C. E. and Frederick, Bd}, + title = {Systemic Low-Frequency Oscillations in BOLD Signal Vary with Tissue Type}, + journal = {Front Neurosci}, + volume = {10}, + number = {7}, + pages = {313}, + note = {Tong, Yunjie +Hocke, Lia M +Lindsey, Kimberly P +Erdogan, Sinem B +Vitaliano, Gordana +Caine, Carolyn E +Frederick, Blaise deB +eng +K08 DA037465/DA/NIDA NIH HHS/ +K25 DA031769/DA/NIDA NIH HHS/ +Switzerland +Front Neurosci. 2016 Jun 30;10:313. doi: 10.3389/fnins.2016.00313. eCollection 2016.}, + abstract = {Blood-oxygen-level dependent (BOLD) signals are widely used in functional magnetic resonance imaging (fMRI) as a proxy measure of brain activation. However, because these signals are blood-related, they are also influenced by other physiological processes. This is especially true in resting state fMRI, during which no experimental stimulation occurs. Previous studies have found that the amplitude of resting state BOLD is closely related to regional vascular density. In this study, we investigated how some of the temporal fluctuations of the BOLD signal also possibly relate to regional vascular density. We began by identifying the blood-bound systemic low-frequency oscillation (sLFO). We then assessed the distribution of all voxels based on their correlations with this sLFO. We found that sLFO signals are widely present in resting state BOLD signals and that the proportion of these sLFOs in each voxel correlates with different tissue types, which vary significantly in underlying vascular density. These results deepen our understanding of the BOLD signal and suggest new imaging biomarkers based on fMRI data, such as amplitude of low-frequency fluctuation (ALFF) and sLFO, a combination of both, for assessing vascular density.}, + keywords = {Bold +amplitude of low-frequency fluctuation +low frequency oscillation +resting state fMRI +vascular density}, + ISSN = {1662-4548 (Print) +1662-453X (Linking)}, + DOI = {10.3389/fnins.2016.00313}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/27445680}, + year = {2016}, + type = {Journal Article} +} + +@article{RN563, + author = {Tong, Y. and Hocke, L. M. and Nickerson, L. D. and Licata, S. C. and Lindsey, K. P. and Frederick, B. D.}, + title = {Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks}, + journal = {Neuroimage}, + volume = {76}, + pages = {202-15}, + abstract = {Independent component analysis (ICA) is widely used in resting state functional connectivity studies. ICA is a data-driven method, which uses no a priori anatomical or functional assumptions. However, as a result, it still relies on the user to distinguish the independent components (ICs) corresponding to neuronal activation, peripherally originating signals (without directly attributable neuronal origin, such as respiration, cardiac pulsation and Mayer wave), and acquisition artifacts. In this concurrent near infrared spectroscopy (NIRS)/functional MRI (fMRI) resting state study, we developed a method to systematically and quantitatively identify the ICs that show strong contributions from signals originating in the periphery. We applied group ICA (MELODIC from FSL) to the resting state data of 10 healthy participants. The systemic low frequency oscillation (LFO) detected simultaneously at each participant's fingertip by NIRS was used as a regressor to correlate with every subject-specific IC time course. The ICs that had high correlation with the systemic LFO were those closely associated with previously described sensorimotor, visual, and auditory networks. The ICs associated with the default mode and frontoparietal networks were less affected by the peripheral signals. The consistency and reproducibility of the results were evaluated using bootstrapping. This result demonstrates that systemic, low frequency oscillations in hemodynamic properties overlay the time courses of many spatial patterns identified in ICA analyses, which complicates the detection and interpretation of connectivity in these regions of the brain.}, + ISSN = {1095-9572}, + DOI = {10.1016/j.neuroimage.2013.03.019}, + url = {http://www.ncbi.nlm.nih.gov/pubmed/23523805}, + year = {2013}, + type = {Journal Article} +} + +@article{RN3638, + author = {Tong, Y. and Hocke, L. M. and Nickerson, L. D. and Licata, S. C. and Lindsey, K. P. and Frederick, Bd}, + title = {Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks}, + journal = {Neuroimage}, + volume = {76}, + pages = {202-15}, + note = {Tong, Yunjie +Hocke, Lia M +Nickerson, Lisa D +Licata, Stephanie C +Lindsey, Kimberly P +Frederick, Blaise deB +eng +K01 DA023659/DA/NIDA NIH HHS/ +K25 DA031769/DA/NIDA NIH HHS/ +R21 DA027877/DA/NIDA NIH HHS/ +T32 DA015036/DA/NIDA NIH HHS/ +Evaluation Studies +Research Support, N.I.H., Extramural +Neuroimage. 2013 Aug 1;76:202-15. doi: 10.1016/j.neuroimage.2013.03.019. Epub 2013 Mar 21.}, + abstract = {Independent component analysis (ICA) is widely used in resting state functional connectivity studies. ICA is a data-driven method, which uses no a priori anatomical or functional assumptions. However, as a result, it still relies on the user to distinguish the independent components (ICs) corresponding to neuronal activation, peripherally originating signals (without directly attributable neuronal origin, such as respiration, cardiac pulsation and Mayer wave), and acquisition artifacts. In this concurrent near infrared spectroscopy (NIRS)/functional MRI (fMRI) resting state study, we developed a method to systematically and quantitatively identify the ICs that show strong contributions from signals originating in the periphery. We applied group ICA (MELODIC from FSL) to the resting state data of 10 healthy participants. The systemic low frequency oscillation (LFO) detected simultaneously at each participant's fingertip by NIRS was used as a regressor to correlate with every subject-specific IC time course. The ICs that had high correlation with the systemic LFO were those closely associated with previously described sensorimotor, visual, and auditory networks. The ICs associated with the default mode and frontoparietal networks were less affected by the peripheral signals. The consistency and reproducibility of the results were evaluated using bootstrapping. This result demonstrates that systemic, low frequency oscillations in hemodynamic properties overlay the time courses of many spatial patterns identified in ICA analyses, which complicates the detection and interpretation of connectivity in these regions of the brain.}, + keywords = {Adult +*Artifacts +Brain/*physiology +Connectome/*methods +Female +Humans +Magnetic Resonance Imaging +Male +Rest/*physiology +Spectroscopy, Near-Infrared}, + ISSN = {1095-9572 (Electronic) +1053-8119 (Linking)}, + DOI = {10.1016/j.neuroimage.2013.03.019}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/23523805}, + year = {2013}, + type = {Journal Article} +} + +@article{RN508, + author = {Tong, Y. J. and Bergethon, P. R. and Frederick, B. D.}, + title = {An improved method for mapping cerebrovascular reserve using concurrent fMRI and near-infrared spectroscopy with Regressor Interpolation at Progressive Time Delays (RIPTiDe)}, + journal = {Neuroimage}, + volume = {56}, + number = {4}, + pages = {2047-2057}, + note = {Tong, Yunjie Bergethon, Peter R. Frederick, Blaise deB}, + abstract = {Cerebrovascular reserve (CVR) reflects the compensatory dilatory capacity of cerebral vasculature to a dilatory stimulus. Blood oxygen-level dependent (BOLD) fMRI has been proven to be an effective imaging technique to obtain CVR maps when subjects perform CO(2) inhalation or a breath-holding (BH) task. Here we propose a novel way to process the fMRI data obtained during a blocked BH task by using simultaneously collected near-infrared spectroscopy (NIRS) data as regressors to estimate the vascular contribution to the BOLD signal. Six healthy subjects underwent a 6 min 30 s resting state (RS) fMRI scan, followed by a scan of the same duration with a blocked BH task (5 breath holds with 20s durations separated by similar to 50 s of regular breathing). NIRS data were recorded from a probe over the subjects' right prefrontal area. For each scan, the time course of changes in total hemoglobin (Delta[tHb]) was calculated from the NIRS data, time shifted by various amounts, and resampled to the fMRI acquisition rate. Each shifted time course was used as regressor in a general linear model analysis. The maximum parameter estimate across all time shifts was calculated at all voxels in both the BH and RS scans, and then converted into signal percentage changes. The ratio of these signal changes generates a CVR map of the BH response, normalized to the resting state. The NIRS regressor method makes no assumptions about the shape (or presence) of the BH response, and allows direct, quantitative comparison of the vascular BOLD response to BH to the baseline map obtained in the resting state. (C) 2011 Elsevier Inc. All rights reserved.}, + ISSN = {1053-8119}, + DOI = {10.1016/j.neuroimage.2011.03.071}, + url = {://WOS:000291457500017}, + year = {2011}, + type = {Journal Article} +} + +@article{RN509, + author = {Tong, Y. J. and Frederick, B. D.}, + title = {Time lag dependent multimodal processing of concurrent fMRI and near-infrared spectroscopy (NIRS) data suggests a global circulatory origin for low-frequency oscillation signals in human brain}, + journal = {Neuroimage}, + volume = {53}, + number = {2}, + pages = {553-564}, + note = {Tong, Yunjie Frederick, Blaise deB.}, + abstract = {Low frequency oscillations (LFOs), characterized by frequencies in the range 0 01-0 1 Hz are commonly observed in blood-related brain functional measurements such as near-infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI). While their physiological origin and implications are not fully understood, these signals are believed to reflect some types of neuronal signaling, systemic hemodynamics. and/or cerebral vascular auto-regulation processes Here, we examine a new method of integrated processing of concurrent NIRS and fMRI data collected on six human subjects during a whole brain resting state acquisition The method combines the high spatial resolution offered by fMRI (similar to 3 mm) and the high temporal resolution offered by NIRS (similar to 80 ms) to allow for the quantitative assessment of temporal relationships between the LFOs observed at different spatial locations in fMRI data This temporal relationship allowed us to infer that the origin of a large proportion of the LFOs is independent of the baseline neural activity The spatio-temporal pattern of LFOs detected by NIRS and fMRI evolves temporally through the brain in a way that resembles cerebral blood flow dynamics. Our results suggest that a major component of the LFOs arise from fluctuations in the blood flow and hemoglobin oxygenation at a global circulatory system level (C) 2010 Elsevier Inc All rights reserved.}, + ISSN = {1053-8119}, + DOI = {10.1016/j.neuroimage.2010.06.049}, + url = {://WOS:000281688000019}, + year = {2010}, + type = {Journal Article} +} + +@article{RN504, + author = {Tong, Y. J. and Frederick, B. D.}, + title = {Concurrent fNIRS and fMRI processing allows independent visualization of the propagation of pressure waves and bulk blood flow in the cerebral vasculature}, + journal = {Neuroimage}, + volume = {61}, + number = {4}, + pages = {1419-1427}, + note = {Tong, Yunjie Frederick, Blaise deB.}, + abstract = {Blood Oxygen Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) measures changes in blood oxygenation, which is affected by physiological processes, including cardiac pulsation, breathing, and low frequency oscillations (LFO). It is challenging to identify spatial and temporal effects of these processes on the BOLD signal because the low sampling rate of BOLD leads to aliasing of higher frequency physiological signal components. In this study, we used concurrent functional near infrared spectroscopy (fNIRS) and fMRI on 6 subjects during a resting state scan. To reduce aliasing, the BOLD fMRI acquisition was repeatedly performed on a set of sequentially acquired slice stacks to lower the TR to 0.5 s while retaining high spatial resolution. Regressor interpolation at progressive time delays (RIPTiDe) method was used, in which physiological signal acquired by fNIRS (without aliasing) and its temporal shifts were used as regressors in the fMRI analysis to determine the magnitude and timing of the effects of various physiological processes on the BOLD signal. The details of the timing of the passage of the cardiac pulsation wave and of the cerebral blood itself were mapped. The result suggests that the cardiac signal affects the voxels near large blood vessels (arteries and veins) most strongly, while LFO mostly affected the drainage veins. We hypothesize that this could be the result of differences in the cerebral blood path lengths, and differences in the dynamics of the propagation of the signals. Together these results validate and extend a novel imaging technique to dynamically track the pulse-wave and bulk blood flow with concurrent fMRI and fNIRS. (C) 2012 Elsevier Inc. All rights reserved.}, + ISSN = {1053-8119}, + DOI = {10.1016/j.neuroimage.2012.03.009}, + url = {://WOS:000305920600065}, + year = {2012}, + type = {Journal Article} +} + +@article{RN507, + author = {Tong, Y. J. and Hocke, L. M. and Frederick, B. D.}, + title = {Isolating the sources of widespread physiological fluctuations in functional near-infrared spectroscopy signals}, + journal = {Journal of Biomedical Optics}, + volume = {16}, + number = {10}, + note = {Tong, Yunjie Hocke, Lia Maria Frederick, Blaise deB}, + abstract = {Physiological fluctuations at low frequency (<0.1 Hz) are prominent in functional near-infrared spectroscopy (fNIRS) measurements in both resting state and functional task studies. In this study, we used the high spatial resolution and full brain coverage of functional magnetic resonance imaging (fMRI) to understand the origins and commonalities of these fluctuations. Specifically, we applied a newly developed method, regressor interpolation at progressive time delays, to analyze concurrently recorded fNIRS and fMRI data acquired both in a resting state study and in a finger tapping study. The method calculates the voxelwise correlations between blood oxygen level dependent (BOLD) fMRI and fNIRS signals with different time shifts and localizes the areas in the brain that highly correlate with the fNIRS signal recorded at the surface of the head. The results show the wide spatial distribution of this physiological fluctuation in BOLD data, both in task and resting states. The brain areas that are highly correlated with global physiological fluctuations observed by fNIRS have a pattern that resembles the venous system of the brain, indicating the blood fluctuation from veins on the brain surface might strongly contribute to the overall fNIRS signal. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3638128]}, + ISSN = {1083-3668}, + DOI = {10.1117/1.3638128}, + url = {://WOS:000297465200012}, + year = {2011}, + type = {Journal Article} +} + +@article{RN506, + author = {Tong, Y. J. and Lindsey, K. P. and Frederick, B. D.}, + title = {Partitioning of physiological noise signals in the brain with concurrent near-infrared spectroscopy and fMRI}, + journal = {Journal of Cerebral Blood Flow and Metabolism}, + volume = {31}, + number = {12}, + pages = {2352-2362}, + note = {Tong, Yunjie Lindsey, Kimberly P. Frederick, Blaise deB}, + abstract = {The blood-oxygen level dependent (BOLD) signals measured by functional magnetic resonance imaging (fMRI) are contaminated with noise from various physiological processes, such as spontaneous low-frequency oscillations (LFOs), respiration, and cardiac pulsation. These processes are coupled to the BOLD signal by different mechanisms, and represent variations with very different frequency content; however, because of the low sampling rate of fMRI, these signals are generally not separable by frequency, as the cardiac and respiratory waveforms alias into the LFO band. In this study, we investigated the spatial and temporal characteristics of the individual noise processes by conducting concurrent near-infrared spectroscopy (NIRS) and fMRI studies on six subjects during a resting state acquisition. Three time series corresponding to LFO, respiration, and cardiac pulsation were extracted by frequency from the NIRS signal (which has sufficient temporal resolution to critically sample the cardiac waveform) and used as regressors in a BOLD fMRI analysis. Our results suggest that LFO and cardiac signals modulate the BOLD signal independently through the circulatory system. The spatiotemporal evolution of the LFO signal in the BOLD data correlates with the global cerebral blood flow. Near-infrared spectroscopy can be used to partition these contributing factors and independently determine their contribution to the BOLD signal. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 2352-2362; doi:10.1038/jcbfm.2011.100; published online 3 August 2011}, + ISSN = {0271-678X}, + DOI = {10.1038/jcbfm.2011.100}, + url = {://WOS:000297759400012}, + year = {2011}, + type = {Journal Article} +} + +@article{RN3649, + author = {Tong, Y. and Lindsey, K. P. and de, B. Frederick B.}, + title = {Partitioning of physiological noise signals in the brain with concurrent near-infrared spectroscopy and fMRI}, + journal = {J Cereb Blood Flow Metab}, + volume = {31}, + number = {12}, + pages = {2352-62}, + note = {Tong, Yunjie +Lindsey, Kimberly P +deB Frederick, Blaise +eng +R21 DA027877/DA/NIDA NIH HHS/ +R21-DA027877/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +J Cereb Blood Flow Metab. 2011 Dec;31(12):2352-62. doi: 10.1038/jcbfm.2011.100. Epub 2011 Aug 3.}, + abstract = {The blood-oxygen level dependent (BOLD) signals measured by functional magnetic resonance imaging (fMRI) are contaminated with noise from various physiological processes, such as spontaneous low-frequency oscillations (LFOs), respiration, and cardiac pulsation. These processes are coupled to the BOLD signal by different mechanisms, and represent variations with very different frequency content; however, because of the low sampling rate of fMRI, these signals are generally not separable by frequency, as the cardiac and respiratory waveforms alias into the LFO band. In this study, we investigated the spatial and temporal characteristics of the individual noise processes by conducting concurrent near-infrared spectroscopy (NIRS) and fMRI studies on six subjects during a resting state acquisition. Three time series corresponding to LFO, respiration, and cardiac pulsation were extracted by frequency from the NIRS signal (which has sufficient temporal resolution to critically sample the cardiac waveform) and used as regressors in a BOLD fMRI analysis. Our results suggest that LFO and cardiac signals modulate the BOLD signal independently through the circulatory system. The spatiotemporal evolution of the LFO signal in the BOLD data correlates with the global cerebral blood flow. Near-infrared spectroscopy can be used to partition these contributing factors and independently determine their contribution to the BOLD signal.}, + keywords = {Adult +Brain/*physiology +Cerebrovascular Circulation/physiology +Electroencephalography +Female +Heart/physiology +Humans +Image Processing, Computer-Assisted +Magnetic Resonance Imaging/*methods +Male +Oxygen/blood +Oxyhemoglobins/analysis +Respiratory Mechanics/physiology +Spectroscopy, Near-Infrared/*methods}, + ISSN = {1559-7016 (Electronic) +0271-678X (Linking)}, + DOI = {10.1038/jcbfm.2011.100}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/21811288}, + year = {2011}, + type = {Journal Article} +} + +@article{RN3627, + author = {Tong, Y. and Lindsey, K. P. and Hocke, L. M. and Vitaliano, G. and Mintzopoulos, D. and Frederick, B. D.}, + title = {Perfusion information extracted from resting state functional magnetic resonance imaging}, + journal = {J Cereb Blood Flow Metab}, + volume = {37}, + number = {2}, + pages = {564-576}, + note = {Tong, Yunjie +Lindsey, Kimberly P +Hocke, Lia M +Vitaliano, Gordana +Mintzopoulos, Dionyssios +Frederick, Blaise deB +eng +K08 DA037465/DA/NIDA NIH HHS/ +K25 DA031769/DA/NIDA NIH HHS/ +R21 DA032746/DA/NIDA NIH HHS/ +J Cereb Blood Flow Metab. 2017 Feb;37(2):564-576. doi: 10.1177/0271678X16631755. Epub 2016 Jul 20.}, + abstract = {It is widely known that blood oxygenation level dependent (BOLD) contrast in functional magnetic resonance imaging (fMRI) is an indirect measure for neuronal activations through neurovascular coupling. The BOLD signal is also influenced by many non-neuronal physiological fluctuations. In previous resting state (RS) fMRI studies, we have identified a moving systemic low frequency oscillation (sLFO) in BOLD signal and were able to track its passage through the brain. We hypothesized that this seemingly intrinsic signal moves with the blood, and therefore, its dynamic patterns represent cerebral blood flow. In this study, we tested this hypothesis by performing Dynamic Susceptibility Contrast (DSC) MRI scans (i.e. bolus tracking) following the RS scans on eight healthy subjects. The dynamic patterns of sLFO derived from RS data were compared with the bolus flow visually and quantitatively. We found that the flow of sLFO derived from RS fMRI does to a large extent represent the blood flow measured with DSC. The small differences, we hypothesize, are largely due to the difference between the methods in their sensitivity to different vessel types. We conclude that the flow of sLFO in RS visualized by our time delay method represents the blood flow in the capillaries and veins in the brain.}, + keywords = {Adult +Brain/*blood supply +Brain Mapping/methods +*Cerebrovascular Circulation +Humans +Magnetic Resonance Imaging/*methods +Middle Aged +Oxygen/blood +Perfusion/methods +Blood oxygenation level dependent contrast +cerebral blood flow +cerebral blood flow measurement +functional magnetic resonance imaging +perfusion weighted magnetic resonance imaging}, + ISSN = {1559-7016 (Electronic) +0271-678X (Linking)}, + DOI = {10.1177/0271678X16631755}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/26873885}, + year = {2017}, + type = {Journal Article} +} + +@article{RN500, + author = {Tong, Y. and Sassaroli, A. and Frederick, B. B. and Fantini, S.}, + title = {New way of comparing near-infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI) during brain activation}, + journal = {Lasers in Surgery and Medicine}, + pages = {84-84}, + note = {Times Cited: 0 +18 +26th Annual Meeting of the American-Society-for-Laser-Medicine-and-Surgery +APR 05-09, 2006 +Boston, MA +Amer Soc Laser Med & Surg}, + url = {://WOS:000236412900255}, + year = {2006}, + type = {Journal Article} +} + +@article{RN560, + author = {Tong, Yunjie and Hocke, Lia Maria and Licata, Stephanie C and Frederick, Blaise deB}, + title = {Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signals}, + journal = {Journal of biomedical optics}, + volume = {17}, + number = {10}, + pages = {106004-1-106004-10}, + abstract = {Abstract. Low-frequency oscillations (LFOs) in the range of 0.01–0.15 Hz are commonly observed in functional imaging studies, such as blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) and functional near-infrared spectroscopy ( ...}, + DOI = {10.1117/1.JBO.17.10.106004}, + url = {http://biomedicaloptics.spiedigitallibrary.org.ezp-prod1.hul.harvard.edu/article.aspx?articleid=1372912}, + year = {2012}, + type = {Journal Article} +} + +@article{RN2810, + author = {Tong, Yunjie and Yao, Jinxia Fiona and Chen, J Jean and Frederick, Blaise deB}, + title = {The resting-state fMRI arterial signal predicts differential blood transit time through the brain.}, + journal = {J Cereb Blood Flow Metab}, + volume = {90}, + number = {1}, + pages = {271678X17753329}, + abstract = {Previous studies have found that aperiodic, systemic low-frequency oscillations (sLFOs) are present in blood-oxygen-level-dependent (BOLD) data. These signals are in the same low frequency band as the "resting state" signal; however, they are distinct signals which represent non-neuronal, physiological oscillations. The same sLFOs are found in the periphery (i.e. finger tips) as changes in oxy/deoxy-hemoglobin concentration using concurrent near-infrared spectroscopy. Together, this evidence points toward an extra-cerebral origin of these sLFOs. If this is the case, it is expected that these sLFO signals would be found in the carotid arteries with time delays that precede the signals found in the brain. To test this hypothesis, we employed the publicly available MyConnectome dataset (a two-year longitudinal study of a single subject) to extract the sLFOs in the internal carotid arteries (ICAs) with the help of the T1/T2-weighted images. Significant, but negative, correlations were found between the LFO BOLD signals from the ICAs and (1) the global signal (GS), (2) the superior sagittal sinus, and (3) the jugulars. We found the consistent time delays between the sLFO signals from ICAs, GS and veins which coincide with the blood transit time through the cerebral vascular tree.}, + url = {http://journals.sagepub.com/doi/10.1177/0271678X17753329}, + year = {2018}, + type = {Journal Article} +} + +@article{RN555, + author = {Vimal, R. L. P. and Pandey-Vimal, M. U. C. and Vimal, L. S. P. and Frederick, B. B. and Stopa, E. G. and Renshaw, P. F. and Vimal, S. P. and Harper, D. G.}, + title = {Activation of suprachiasmatic nuclei and primary visual cortex depends upon time of day}, + journal = {European Journal of Neuroscience}, + volume = {29}, + number = {2}, + pages = {399-410}, + note = {Vimal, Ram L. P. Pandey-Vimal, Manju-Uma C. Vimal, Love-Shyam P. Frederick, Blaise B. Stopa, Edward G. Renshaw, Perry F. Vimal, Shalini P. Harper, David G.}, + abstract = {The human suprachiasmatic nucleus (SCN), the master biological clock, is a small (similar to 2 mm(3)) and deep structure located in the anterior hypothalamus. Previous methods do not allow in vivo study of the human SCN in a non-invasive manner. Therefore, we explored blood oxygen level-dependent (BOLD)-functional magnetic resonance imaging (fMRI) with OFF-ON-OFF block-designed visual stimuli to record the activities in the 'SCN and peri SCN in the anterior hypothalamus' (SCN(+)) and the primary visual area V1 using a 3T Siemens scanner and six normal subjects. We found that: (i) the BOLD-fMRI response to light and the mean of percentage activation in the SCN(+) at midday was significantly less than that at night; and (ii) the number of activated voxels in most of the visual area V1 at midday was significantly higher than that at night. We conclude that BOLD-fMRI responses to light in the SCN(+) and the V1 areas vary with time of day. This conclusion is consistent with: (i) the previously measured phase-response curve to light [J. Physiol., 549.3 (2003) 945] for the SCN activity at critical intensity threshold; and (ii) the interaction of the melanopsin-based signals with the rod-cone signals at the 'giant' retinal ganglion cells [Nature, 433 (2005) 749] for the V1 activity.}, + ISSN = {0953-816X}, + DOI = {10.1111/j.1460-9568.2008.06582.x}, + url = {://WOS:000262515600017}, + year = {2009}, + type = {Journal Article} +} + +@article{RN3657, + author = {Vimal, R. L. and Pandey-Vimal, M. U. and Vimal, L. S. and Frederick, B. B. and Stopa, E. G. and Renshaw, P. F. and Vimal, S. P. and Harper, D. G.}, + title = {Activation of suprachiasmatic nuclei and primary visual cortex depends upon time of day}, + journal = {Eur J Neurosci}, + volume = {29}, + number = {2}, + pages = {399-410}, + note = {Vimal, Ram L P +Pandey-Vimal, Manju-Uma C +Vimal, Love-Shyam P +Frederick, Blaise B +Stopa, Edward G +Renshaw, Perry F +Vimal, Shalini P +Harper, David G +eng +AG20654/AG/NIA NIH HHS/ +DA09448/DA/NIDA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, Non-U.S. Gov't +France +Eur J Neurosci. 2009 Jan;29(2):399-410. doi: 10.1111/j.1460-9568.2008.06582.x.}, + abstract = {The human suprachiasmatic nucleus (SCN), the master biological clock, is a small (approximately 2 mm(3)) and deep structure located in the anterior hypothalamus. Previous methods do not allow in vivo study of the human SCN in a non-invasive manner. Therefore, we explored blood oxygen level-dependent (BOLD)-functional magnetic resonance imaging (fMRI) with OFF-ON-OFF block-designed visual stimuli to record the activities in the 'SCN and peri SCN in the anterior hypothalamus' (SCN+) and the primary visual area V1 using a 3T Siemens scanner and six normal subjects. We found that: (i) the BOLD-fMRI response to light and the mean of percentage activation in the SCN+ at midday was significantly less than that at night; and (ii) the number of activated voxels in most of the visual area V1 at midday was significantly higher than that at night. We conclude that BOLD-fMRI responses to light in the SCN+ and the V1 areas vary with time of day. This conclusion is consistent with: (i) the previously measured phase-response curve to light [J. Physiol., 549.3 (2003) 945] for the SCN activity at critical intensity threshold; and (ii) the interaction of the melanopsin-based signals with the rod-cone signals at the 'giant' retinal ganglion cells [Nature, 433 (2005) 749] for the V1 activity.}, + keywords = {Adult +Biological Clocks/physiology +Brain Mapping +Circadian Rhythm/*physiology +Female +Humans +Magnetic Resonance Imaging +Male +Photic Stimulation +Retina/cytology/*physiology +Retinal Ganglion Cells/physiology +Rod Opsins/physiology +Sensory Thresholds/physiology +Suprachiasmatic Nucleus/cytology/*physiology +Time Factors +Vision, Ocular/physiology +Visual Cortex/cytology/*physiology +Visual Pathways/cytology/*physiology +Young Adult}, + ISSN = {1460-9568 (Electronic) +0953-816X (Linking)}, + DOI = {10.1111/j.1460-9568.2008.06582.x}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/19200242}, + year = {2009}, + type = {Journal Article} +} + +@article{RN495, + author = {Vimal, Ram L. P. and Pandey-Vimal, Manju-Uma C. and Vimal, Love-Shyam P. and Frederick, Blaise B. and Stopa, Edward G. and Renshaw, Perry F. and Vimal, Shalini P. and Harper, David G.}, + title = {Activation of suprachiasmatic nuclei and primary visual cortex depends upon time of day}, + journal = {European Journal of Neuroscience}, + volume = {29}, + number = {2}, + pages = {399-410}, + note = {Times Cited: 2}, + abstract = {The human suprachiasmatic nucleus (SCN), the master biological clock, is a small (similar to 2 mm(3)) and deep structure located in the anterior hypothalamus. Previous methods do not allow in vivo study of the human SCN in a non-invasive manner. Therefore, we explored blood oxygen level-dependent (BOLD)-functional magnetic resonance imaging (fMRI) with OFF-ON-OFF block-designed visual stimuli to record the activities in the 'SCN and peri SCN in the anterior hypothalamus' (SCN(+)) and the primary visual area V1 using a 3T Siemens scanner and six normal subjects. We found that: (i) the BOLD-fMRI response to light and the mean of percentage activation in the SCN(+) at midday was significantly less than that at night; and (ii) the number of activated voxels in most of the visual area V1 at midday was significantly higher than that at night. We conclude that BOLD-fMRI responses to light in the SCN(+) and the V1 areas vary with time of day. This conclusion is consistent with: (i) the previously measured phase-response curve to light [J. Physiol., 549.3 (2003) 945] for the SCN activity at critical intensity threshold; and (ii) the interaction of the melanopsin-based signals with the rod-cone signals at the 'giant' retinal ganglion cells [Nature, 433 (2005) 749] for the V1 activity.}, + DOI = {10.1111/j.1460-9568.2008.06582.x}, + url = {://WOS:000262515600017}, + year = {2009}, + type = {Journal Article} +} + +@article{RN529, + author = {Wald, L. L. and Frederick, B. D. and Renshaw, P. F.}, + title = {NAA-weighted imaging of the human brain using a conventional readout gradient}, + journal = {Magnetic Resonance in Medicine}, + volume = {41}, + number = {1}, + pages = {187-192}, + note = {Wald, LL Frederick, BD Renshaw, PF}, + abstract = {An imaging sequence incorporating two complementary forms of water suppression was used in conjunction with conventional readout and phase-encoding gradients to acquire images of N-acetylaspartate (NAA) in human brain. The sequence consisted of CHESS water suppression pulses followed by dual echo sequence to select the imaging volume and frequency-selective refocusing pulses with asymmetric crushers to further reduce the water signal, Spectra and conventional spectroscopic images acquired with the sequence demonstrated robust suppression of water and other resonances down field from the 2.0-ppm NAA resonance with 98% of the brain signal resulting from the 3.0-ppm to 2.0-ppm region. The technique was found to provide NAA maps with a large (256 x 128) imaging matrix and to allow a flexible tradeoff between signal to noise ratio (SNR), matrix size, data acquisition window length, and imaging time. Since spectral information is not directly obtained, the length of the data acquisition window is not determined by the spectral resolution needed to resolve the components of the brain spectrum, allowing a significantly shorter readout period. The shorter acquisition window could potentially facilitate the acquisition of multi-echo or multi-slice brain NAA maps. Magn Reson Med 41:187-192, 1999. (C) 1999 Wiley-Liss, Inc.}, + ISSN = {0740-3194}, + DOI = {10.1002/(sici)1522-2594(199901)41:1<187::aid-mrm26>3.0.co;2-r}, + url = {://WOS:000078336800026}, + year = {1999}, + type = {Journal Article} +} + +@article{RN3669, + author = {Wald, L. L. and Frederick, B. and Renshaw, P. F.}, + title = {NAA-weighted imaging of the human brain using a conventional readout gradient}, + journal = {Magn Reson Med}, + volume = {41}, + number = {1}, + pages = {187-92}, + note = {Wald, L L +Frederick, B +Renshaw, P F +eng +DA-09448/DA/NIDA NIH HHS/ +MA-54695/PHS HHS/ +Comparative Study +Research Support, U.S. Gov't, P.H.S. +Magn Reson Med. 1999 Jan;41(1):187-92.}, + abstract = {An imaging sequence incorporating two complementary forms of water suppression was used in conjunction with conventional readout and phase-encoding gradients to acquire images of N-acetylaspartate (NAA) in human brain. The sequence consisted of CHESS water suppression pulses followed by dual echo sequence to select the imaging volume and frequency-selective refocusing pulses with asymmetric crushers to further reduce the water signal. Spectra and conventional spectroscopic images acquired with the sequence demonstrated robust suppression of water and other resonances down field from the 2.0-ppm NAA resonance with 98% of the brain signal resulting from the 3.0-ppm to 2.0-ppm region. The technique was found to provide NAA maps with a large (256 x 128) imaging matrix and to allow a flexible tradeoff between signal to noise ratio (SNR), matrix size, data acquisition window length, and imaging time. Since spectral information is not directly obtained, the length of the data acquisition window is not determined by the spectral resolution needed to resolve the components of the brain spectrum, allowing a significantly shorter readout period. The shorter acquisition window could potentially facilitate the acquisition of multi-echo or multi-slice brain NAA maps.}, + keywords = {Artifacts +Aspartic Acid/*analogs & derivatives/metabolism +Body Water/metabolism +Brain/*metabolism +Humans +Magnetic Resonance Imaging/*methods +Phantoms, Imaging}, + ISSN = {0740-3194 (Print) +0740-3194 (Linking)}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/10025628}, + year = {1999}, + type = {Journal Article} +} + +@article{RN3723, + author = {Watchmaker, J. M. and Frederick, B. D. and Fusco, M. R. and Davis, L. T. and Juttukonda, M. R. and Lants, S. K. and Kirshner, H. S. and Donahue, M. J.}, + title = {Clinical Use of Cerebrovascular Compliance Imaging to Evaluate Revascularization in Patients With Moyamoya}, + journal = {Neurosurgery}, + note = {Watchmaker, Jennifer M +Frederick, Blaise deB +Fusco, Matthew R +Davis, Larry T +Juttukonda, Meher R +Lants, Sarah K +Kirshner, Howard S +Donahue, Manus J +eng +R01 NS097763/NS/NINDS NIH HHS/ +T32 EB014841/EB/NIBIB NIH HHS/ +Neurosurgery. 2018 Mar 8. pii: 4924826. doi: 10.1093/neuros/nyx635.}, + abstract = {BACKGROUND: Surgical revascularization is often performed in patients with moyamoya, however routine tools for efficacy evaluation are underdeveloped. The gold standard is digital subtraction angiography (DSA); however, DSA requires ionizing radiation and procedural risk, and therefore is suboptimal for routine surveillance of parenchymal health. OBJECTIVE: To determine whether parenchymal vascular compliance measures, obtained noninvasively using magnetic resonance imaging (MRI), provide surrogates to revascularization success by comparing measures with DSA before and after surgical revascularization. METHODS: Twenty surgical hemispheres with DSA and MRI performed before and after revascularization were evaluated. Cerebrovascular reactivity (CVR)-weighted images were acquired using hypercapnic 3-Tesla gradient echo blood oxygenation level-dependent MRI. Standard and novel analysis algorithms were applied (i) to quantify relative CVR (rCVRRAW), and decompose this response into (ii) relative maximum CVR (rCVRMAX) and (iii) a surrogate measure of the time for parenchyma to respond maximally to the stimulus, CVRDELAY. Measures between time points in patients with good and poor surgical outcomes based on DSA-visualized neoangiogenesis were contrasted (signed-rank test; significance: 2-sided P < .050). RESULTS: rCVRRAW increases (P = .010) and CVRDELAY decreases (P = .001) were observed pre- vs post-revascularization in hemispheres with DSA-confirmed collateral formation; no difference was found pre- vs post-revascularization in hemispheres with poor revascularization. No significant change in rCVRMAX post-revascularization was observed in either group, or between any of the MRI measures, in the nonsurgical hemisphere. CONCLUSION: Improvement in parenchymal compliance measures post-revascularization, primarily attributed to reductions in microvascular response time, is concurrent with collateral formation visualized on DSA, and may be useful for longitudinal monitoring of surgical outcomes.}, + ISSN = {1524-4040 (Electronic) +0148-396X (Linking)}, + DOI = {10.1093/neuros/nyx635}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/29528447}, + year = {2018}, + type = {Journal Article} +} + +@article{RN3630, + author = {Wolk, Paula C. and Savoy, Robert L. and Frederick, Blaise B.}, + title = {The Neural Correlates of Vertical Splitting in a Single Case Study}, + journal = {Neuropsychoanalysis}, + volume = {14}, + number = {2}, + pages = {157-163}, + ISSN = {1529-4145 +2044-3978}, + DOI = {10.1080/15294145.2012.10773699}, + url = {http://www.tandfonline.com/doi/abs/10.1080/15294145.2012.10773699}, + year = {2012}, + type = {Journal Article} +} + +@article{RN544, + author = {Woodward, S. H. and Kaloupek, D. G. and Streeter, C. C. and Kimble, M. O. and Reiss, A. L. and Eliez, S. and Wald, L. L. and Renshaw, P. E. and Frederick, B. B.}, + title = {Brain, skull, and cerebrospinal fluid volumes in adult Posttraumatic stress disorder}, + journal = {Journal of Traumatic Stress}, + volume = {20}, + number = {5}, + pages = {763-774}, + note = {Woodward, Steven H. Kaloupek, Danny G. Streeter, Chris C. Kimble, Matthew O. Reiss, Allan L. Eliez, Stephan Wald, Lawrence L. Renshaw, Perry E. Frederick, Blaise B.}, + abstract = {Children and adolescents with maltreatment-related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among adult PTSD, early trauma, and cerebral volumes in 99 combat veterans. A bone-based estimate of cranial volume was developed to adjust for variation in body size. Posttraumatic stress disorder was not associated with smaller cerebral tissue volume, but rather with smaller cerebrospinal fluid (CSF) and cranial volumes. These findings co-occurred with expected effects of alcoholism and aging on cerebral tissue and CSF volumes. The results point to early developmental divergences between groups with and without PTSD following adult trauma.}, + ISSN = {0894-9867}, + DOI = {10.1002/jts.20241}, + url = {://WOS:000250736400012}, + year = {2007}, + type = {Journal Article} +} + +@article{RN498, + author = {Woodward, S. H. and Kaloupek, D. G. and Streeter, C. C. and Kimble, M. O. and Reiss, A. L. and Eliez, S. and Wald, L. L. and Renshaw, P. F. and Frederick, B. B. and Lane, B. and Sheikh, J. I. and Stegman, W. K. and Kutter, C. J. and Stewart, L. P. and Prestel, R. S. and Arsenault, N. J.}, + title = {Hippocampal volume, PTSD, and alcoholism in combat veterans}, + journal = {American Journal of Psychiatry}, + volume = {163}, + number = {4}, + pages = {674-681}, + note = {Times Cited: 27}, + abstract = {Studies imposing rigorous control over lifetime alcohol intake have usually not found smaller hippocampal volumes in persons with posttraumatic stress disorder. Because the majority of negative studies have used adolescent samples, it has been suggested that chronicity is a necessary condition for such findings. To test the hypothesis that a smaller hippocampus in PTSD is unrelated to comorbid alcoholism or to chronicity, this study estimated hippocampal volume in a relatively large group ( N=99) of combat veterans in which PTSD, lifetime alcohol abuse/dependence, and Vietnam versus Gulf War service were crossed. In subjects with histories of alcoholism, unadjusted hippocampal volume was 9% smaller in persons with PTSD than in those without PTSD. In nonalcoholic subjects, the PTSD-related difference in hippocampal volume was 3%. The failure to observe a strong association between PTSD and hippocampal volume in nonalcoholic subjects was not ascribable to younger age, reduced PTSD chronicity, or lower PTSD symptom severity. The possibility that smaller hippocampal volume is limited to groups in which PTSD is compounded by comorbid alcoholism is not necessarily incompatible with results suggesting a smaller hippocampus is predispositional to PTSD. Further examination of the role of alcoholism and other comorbid conditions in studies of brain structure and function in PTSD appears warranted.}, + DOI = {10.1176/appi.ajp.163.4.674}, + url = {://WOS:000236541200020}, + year = {2006}, + type = {Journal Article} +} + +@article{RN3654, + author = {Woodward, S. H. and Kaloupek, D. G. and Streeter, C. C. and Kimble, M. O. and Reiss, A. L. and Eliez, S. and Wald, L. L. and Renshaw, P. F. and Frederick, B. B. and Lane, B. and Sheikh, J. I. and Stegman, W. K. and Kutter, C. J. and Stewart, L. P. and Prestel, R. S. and Arsenault, N. J.}, + title = {Hippocampal volume, PTSD, and alcoholism in combat veterans}, + journal = {Am J Psychiatry}, + volume = {163}, + number = {4}, + pages = {674-81}, + note = {Woodward, Steven H +Kaloupek, Danny G +Streeter, Chris C +Kimble, Matthew O +Reiss, Allan L +Eliez, Stephan +Wald, Lawrence L +Renshaw, Perry F +Frederick, Blaise B +Lane, Barton +Sheikh, Javaid I +Stegman, Wendy K +Kutter, Catherine J +Stewart, Lorraine P +Prestel, Rebecca S +Arsenault, Ned J +eng +K23AA131149/AA/NIAAA NIH HHS/ +Comparative Study +Research Support, N.I.H., Extramural +Research Support, U.S. Gov't, Non-P.H.S. +Am J Psychiatry. 2006 Apr;163(4):674-81. doi: 10.1176/appi.ajp.163.4.674.}, + abstract = {Studies imposing rigorous control over lifetime alcohol intake have usually not found smaller hippocampal volumes in persons with posttraumatic stress disorder. Because the majority of negative studies have used adolescent samples, it has been suggested that chronicity is a necessary condition for such findings. To test the hypothesis that a smaller hippocampus in PTSD is unrelated to comorbid alcoholism or to chronicity, this study estimated hippocampal volume in a relatively large group (N=99) of combat veterans in which PTSD, lifetime alcohol abuse/dependence, and Vietnam versus Gulf War service were crossed. In subjects with histories of alcoholism, unadjusted hippocampal volume was 9% smaller in persons with PTSD than in those without PTSD. In nonalcoholic subjects, the PTSD-related difference in hippocampal volume was 3%. The failure to observe a strong association between PTSD and hippocampal volume in nonalcoholic subjects was not ascribable to younger age, reduced PTSD chronicity, or lower PTSD symptom severity. The possibility that smaller hippocampal volume is limited to groups in which PTSD is compounded by comorbid alcoholism is not necessarily incompatible with results suggesting a smaller hippocampus is predispositional to PTSD. Further examination of the role of alcoholism and other comorbid conditions in studies of brain structure and function in PTSD appears warranted.}, + keywords = {Adult +Age Factors +Alcoholism/*diagnosis/epidemiology/pathology +Atrophy/pathology +Combat Disorders/*diagnosis/epidemiology/pathology +Comorbidity +Depressive Disorder, Major/diagnosis/epidemiology +Diagnosis, Dual (Psychiatry) +Disease Susceptibility/diagnosis +Female +Gulf War +Hippocampus/*pathology +Humans +Male +Middle Aged +Psychiatric Status Rating Scales +Stress Disorders, Post-Traumatic/*diagnosis/epidemiology/pathology +Veterans/psychology/*statistics & numerical data +Vietnam Conflict +Wechsler Scales}, + ISSN = {0002-953X (Print) +0002-953X (Linking)}, + DOI = {10.1176/appi.ajp.163.4.674}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/16585443}, + year = {2006}, + type = {Journal Article} +} + +@article{RN3656, + author = {Woodward, S. H. and Kaloupek, D. G. and Streeter, C. C. and Kimble, M. O. and Reiss, A. L. and Eliez, S. and Wald, L. L. and Renshaw, P. F. and Frederick, B. B. and Lane, B. and Sheikh, J. I. and Stegman, W. K. and Kutter, C. J. and Stewart, L. P. and Prestel, R. S. and Arsenault, N. J.}, + title = {Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder}, + journal = {J Trauma Stress}, + volume = {20}, + number = {5}, + pages = {763-74}, + note = {Woodward, Steven H +Kaloupek, Danny G +Streeter, Chris C +Kimble, Matthew O +Reiss, Allan L +Eliez, Stephan +Wald, Lawrence L +Renshaw, Perry F +Frederick, Blaise B +Lane, Barton +Sheikh, Javaid I +Stegman, Wendy K +Kutter, Catherine J +Stewart, Lorraine P +Prestel, Rebecca S +Arsenault, Ned J +eng +K23AA13149/AA/NIAAA NIH HHS/ +Research Support, N.I.H., Extramural +Research Support, U.S. Gov't, Non-P.H.S. +J Trauma Stress. 2007 Oct;20(5):763-74. doi: 10.1002/jts.20241.}, + abstract = {Children and adolescents with maltreatment-related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among adult PTSD, early trauma, and cerebral volumes in 99 combat veterans. A bone-based estimate of cranial volume was developed to adjust for variation in body size. Posttraumatic stress disorder was not associated with smaller cerebral tissue volume, but rather with smaller cerebrospinal fluid (CSF) and cranial volumes. These findings co-occurred with expected effects of alcoholism and aging on cerebral tissue and CSF volumes. The results point to early developmental divergences between groups with and without PTSD following adult trauma.}, + keywords = {Adolescent +Brain/*physiopathology +California +Cerebrospinal Fluid/*metabolism +Child +Female +Gulf War +Humans +Magnetic Resonance Imaging +Male +Massachusetts +Skull/*physiopathology +Stress Disorders, Post-Traumatic/*physiopathology +Vietnam Conflict}, + ISSN = {0894-9867 (Print) +0894-9867 (Linking)}, + DOI = {10.1002/jts.20241}, + url = {https://www.ncbi.nlm.nih.gov/pubmed/17955544}, + year = {2007}, + type = {Journal Article} +} + +@article{RN519, + author = {Zahler, R. and Majumdar, S. and Frederick, B. and Laughlin, M. and Barrett, E. and Gore, J. C.}, + title = {NMR DETERMINATION OF MYOCARDIAL PH INVIVO - SEPARATION OF TISSUE INORGANIC-PHOSPHATE FROM BLOOD 2,3-DPG}, + journal = {Magnetic Resonance in Medicine}, + volume = {17}, + number = {2}, + pages = {368-378}, + note = {ZAHLER, R MAJUMDAR, S FREDERICK, B LAUGHLIN, M BARRETT, E GORE, JC}, + ISSN = {0740-3194}, + DOI = {10.1002/mrm.1910170209}, + url = {://WOS:A1991EW71200008}, + year = {1991}, + type = {Journal Article} +} + diff --git a/rapidtide/workflows/rapidtide_parser.py b/rapidtide/workflows/rapidtide_parser.py index b2445731..0dc40c24 100755 --- a/rapidtide/workflows/rapidtide_parser.py +++ b/rapidtide/workflows/rapidtide_parser.py @@ -72,7 +72,7 @@ class _Sentinel: DEFAULT_WINDOW_TYPE = "hamming" DEFAULT_GLOBALMASK_METHOD = "mean" DEFAULT_GLOBALSIGNAL_METHOD = "sum" -DEFAULT_CORRWEIGHTING = "regressor" +DEFAULT_CORRWEIGHTING = "phat" DEFAULT_CORRTYPE = "linear" DEFAULT_SIMILARITYMETRIC = "correlation" DEFAULT_PEAKFIT_TYPE = "gauss"