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clirec.queries.xml
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clirec.queries.xml
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<?xml version="1.0" encoding="UTF-8"?>
<queries>
<query id="A10.1" before="20091101" keywords="limb ischaemia and prostanoids">
<pop>Adults</pop>
<prob>Critical limb ischaemia</prob>
<int>Prostanoids</int>
<comp>Placebo</comp>
<out>mortality reduction</out>
</query>
<query id="A10.2" before="20091101" keywords="limb ischaemia and prostanoids">
<pop>Adults</pop>
<prob>Critical limb ischaemia</prob>
<int>Prostanoids</int>
<comp>other pharmaceuticals controls</comp>
<out>disease progression reduction</out>
</query>
<query id="A11.1" before="20090501" keywords="Quetiapine and schizophrenia">
<pop>Adults</pop>
<prob>Schizophrenia and schizophrenia-like symptoms</prob>
<int>Quetiapine</int>
<comp>Other second generation antipsychotic drugs</comp>
<out>Drug effects</out>
</query>
<query id="A12.1" before="20090201" keywords="Chronic asthma and formoterol and inhaled corticosteroids">
<pop>Adults</pop>
<prob>Chronic asthma</prob>
<int>Regular formoterol + inhaled corticosteroids</int>
<comp>Regular selmeterol + inhaled corticosteroids</comp>
<out>Mortality risk</out>
<dur>12 weeks</dur>
</query>
<query id="A12.2" before="20090201" keywords="Chronic asthma and formoterol and inhaled corticosteroids">
<pop>Adults</pop>
<prob>Chronic asthma</prob>
<int>Regular formoterol + inhaled corticosteroids</int>
<comp>Regular selmeterol + inhaled corticosteroids</comp>
<out>Non-fatal serious adverse events</out>
<dur>12 weeks</dur>
</query>
<query id="A13.1" before="20080201" keywords="hip fracture and physical and psychosocial functioning">
<pop>Older adults</pop>
<prob>Hip fracture</prob>
<int>interventions aimed at improving physical and psychosocial functioning</int>
<comp>No intervention</comp>
<out>physical and psychosocial function</out>
<dur>12 months</dur>
</query>
<query id="A13.2" before="20080201" keywords="hip fracture and physical and psychosocial functioning">
<pop>Older adults</pop>
<prob>Hip fracture</prob>
<int>interventions aimed at improving physical and psychosocial functioning</int>
<comp>No intervention</comp>
<out>"poor outcome" (composite of mortality, failure to return to independent living and/or readmission)</out>
<dur>12 months</dur>
</query>
<query id="A14.1" before="20080201" keywords="Pericoital hormonal contraception">
<pop>Women</pop>
<prob>Pericoital</prob>
<int>Pre- and postcoital hormonal contraception</int>
<comp>No intervention</comp>
<out>Pregnancy prevention</out>
<dur>12 months</dur>
</query>
<query id="A15.1" before="20090501" keywords="Labour (labor) and fluid or food restriction">
<pop>Women</pop>
<prob>Labour (labor)</prob>
<int>oral fluid or food restriction</int>
<comp>free eating and drinking</comp>
<out>Benefits and harm</out>
</query>
<query id="A16.1" before="20090101" keywords="hamstring injuries and prevention">
<pop>Young adults</pop>
<prob>Regularly practicing sports</prob>
<int>Interventions</int>
<comp>No interventions</comp>
<out>preventing hamstring injuries</out>
</query>
<query id="A16.2" before="20090101" keywords="hamstring injuries and prevention">
<pop>Young adults</pop>
<prob>Regularly practicing sports</prob>
<int>Interventions</int>
<comp>No interventions</comp>
<out>Compliance</out>
</query>
<query id="A17.1" before="20060901" keywords="Barrett's oesophagus treatment">
<pop>Adults</pop>
<prob>Barrett's oesophagus</prob>
<int>Pharmacological treatment</int>
<comp>Endoscopic Treatment</comp>
<out>Complete eradication of Barret's oesophagus</out>
<dur>12 months</dur>
</query>
<query id="A17.2" before="20060901" keywords="Barrett's oesophagus treatment">
<pop>Adults</pop>
<prob>Barrett's oesophagus</prob>
<int>Pharmacological treatment</int>
<comp>Non-resectional surgical treatment</comp>
<out>Complete eradication of dysplasia</out>
<dur>12 months</dur>
</query>
<query id="A18.1" before="20091001" keywords="risk of disease and body image and visual feedback">
<pop>Adults</pop>
<prob>Undergoing medical imaging procedures assessing risk of disease or of an existing condition</prob>
<int>Visual feedback of images of individual's bodies</int>
<comp>No feedback</comp>
<out>Increase or decrease in health behaviours</out>
</query>
<query id="A19.1" before="20090301" keywords="asthma and therapy adjustment">
<pop>Children and Adults</pop>
<prob>Asthma</prob>
<int>Methods based on exhaled nitric oxide</int>
<comp>Methods based on primarily clinical symptoms and spirometry/peak flow</comp>
<out>Efficacy of therapy adjustment</out>
</query>
<query id="A20.1" before="20040201" keywords="Tamoxifen and Hepatocellular carcinoma">
<pop>Adults</pop>
<prob>Advanced hepatocellular carcinoma</prob>
<int>Tamoxifen</int>
<comp>Placebo</comp>
<out>Survival</out>
</query>
<query id="A20.2" before="20040201" keywords="Tamoxifen and Hepatocellular carcinoma">
<pop>Adults</pop>
<prob>Advanced hepatocellular carcinoma</prob>
<int>Tamoxifen</int>
<comp>Best supportive care</comp>
<out>quality of life</out>
</query>
<query id="A21.1" before="20090801" keywords="Retinal detachment and tamponade agent">
<pop>Adults</pop>
<prob>Retinal detachment with proliferative vitreoretinopathy</prob>
<int>Surgery + silicone oil</int>
<comp>Surgery + sulphur hexafluoride</comp>
<out>adverse outcomes</out>
</query>
<query id="A1.1" before="20091101" keywords="bariatric surgery and steatohepatitis and obese">
<pop>Obese patients</pop>
<prob>Non-alcoholic steatohepatitis (NASH)</prob>
<int>Bariatric surgery</int>
<comp>No intervention</comp>
<out>All-cause mortality</out>
<dur>Maximal follow-up</dur>
</query>
<query id="A1.2" before="20091101" keywords="bariatric surgery and steatohepatitis and obese">
<pop>Obese patients</pop>
<prob>Non-alcoholic steatohepatitis (NASH)</prob>
<int>Bariatric surgery</int>
<comp>Placebo (Sham procedure)</comp>
<out>Surgical-related mortality</out>
</query>
<query id="A2.1" before="20091001" keywords="Benzodiazepines and respiratory disease">
<pop>Adult patients</pop>
<prob>advanced cancer and COPD</prob>
<int>Benzodiazepines (alprazolam, lorazepam, midazolam, etc)</int>
<comp>Placebo</comp>
<out>breathlessness relief</out>
<dur>5 days (median for all drugs)</dur>
</query>
<query id="A2.2" before="20091001" keywords="Benzodiazepines and respiratory disease">
<pop>Adult patients</pop>
<prob>advanced cancer and COPD</prob>
<int>Benzodiazepines (alprazolam, lorazepam, midazolam, etc)</int>
<comp>Morphine</comp>
<out>breathlessness relief</out>
<dur>5 days (median for all drugs)</dur>
</query>
<query id="A3.1" before="20090801" keywords="hypertension and beta-blockers">
<pop>Adult patients</pop>
<prob>Primary Hypertension</prob>
<int>Beta-blockers and drug from another class of anti-hypertensive</int>
<comp>the other drug from another class of anti-hypertensive alone</comp>
<out>effect on blood pressure and heart rate</out>
<dur>3 to 12 weeks</dur>
</query>
<query id="A22.1" before="20100501" keywords="Tamsulosin and benign prostatic hyperplasia">
<pop>Men</pop>
<prob>Benign prostatic hyperplasia</prob>
<int>Tamusolin</int>
<comp>Placebo</comp>
<out>Lower urinary tract symptoms</out>
</query>
<query id="A22.2" before="20100501" keywords="Tamsulosin and benign prostatic hyperplasia">
<pop>Men</pop>
<prob>Benign prostatic hyperplasia</prob>
<int>Tamusolin</int>
<comp>Surgical interventions</comp>
<out>Urodynamic measures</out>
</query>
<query id="A23.1" before="20070201" keywords="Propofol and general sedation and infusion">
<pop>Adults</pop>
<prob>General anaesthesia</prob>
<int>Target-controlled infusion</int>
<comp>manually-controlled infusion</comp>
<out>Sedation</out>
</query>
<query id="A23.2" before="20070201" keywords="Propofol and general sedation and infusion">
<pop>Adults</pop>
<prob>General anaesthesia</prob>
<int>Target-controlled infusion</int>
<comp>manually-controlled infusion</comp>
<out>Adverse events</out>
</query>
<query id="A24.1" before="20070201" keywords="Targeted therapy and advanced renal cell carcinoma">
<pop>Adults</pop>
<prob>Advanced renal cell carcinoma</prob>
<int>Targeted agents</int>
<comp>Different doses of same agent</comp>
<out>Remission rate</out>
</query>
<query id="A24.2" before="20070201" keywords="Targeted therapy and advanced renal cell carcinoma">
<pop>Adults</pop>
<prob>Advanced renal cell carcinoma</prob>
<int>Targeted agents</int>
<comp>Standard interferon-alfa</comp>
<out>Overall survival</out>
</query>
<query id="A25.1" before="20060201" keywords="Asthma and Tartrazine">
<pop>Adults</pop>
<prob>Asthma</prob>
<int>Tartrazine</int>
<comp>Placebo</comp>
<out>Asthma exacerbation</out>
</query>
<query id="A25.2" before="20060201" keywords="Asthma and Tartrazine">
<pop>Adults</pop>
<prob>Asthma</prob>
<int>Tartrazine dietary avoidance</int>
<comp>Normal diet</comp>
<out>Asthma exacerbation</out>
</query>
<query id="A26.1" before="20070201" keywords="Early breast cancer and Taxanes">
<pop>Women</pop>
<prob>Early breast cancer</prob>
<int>chemotherapy containing Taxane</int>
<comp>chemotherapy no containing Taxane</comp>
<out>Overall survival</out>
<dur>60.4 months (median)</dur>
</query>
<query id="A26.2" before="20070201" keywords="Early breast cancer and Taxanes">
<pop>Women</pop>
<prob>Early breast cancer</prob>
<int>chemotherapy containing Taxane</int>
<comp>chemotherapy no containing Taxane</comp>
<out>disease-free survival</out>
<dur>60.4 months (median)</dur>
</query>
<query id="A27.1" before="20030201" keywords="Caesarian section and closure techniques">
<pop>Women</pop>
<prob>Caesarean section</prob>
<int>closure of subcutaneous fat</int>
<comp>non-closure of subcutaneous fat</comp>
<out>Postoperative recovery</out>
</query>
<query id="A27.2" before="20030201" keywords="Caesarian section and closure techniques">
<pop>Women</pop>
<prob>Caesarean section</prob>
<int>any suturing technique or material used for closure of the rectus sheath</int>
<comp>any other technique</comp>
<out>Healthcare resource use</out>
</query>
<query id="A28.1" before="20050101" keywords="MMR and effectiveness">
<pop>Children</pop>
<prob>healthy, < or = 15 years old</prob>
<int>MMR</int>
<comp>Placebo</comp>
<out>Viral Infection</out>
</query>
<query id="A28.2" before="20050101" keywords="MMR and effectiveness">
<pop>Children</pop>
<prob>healthy, < or = 15 years old</prob>
<int>MMR</int>
<comp>Placebo</comp>
<out>Unintended effects</out>
</query>
<query id="A29.1" before="20081201" keywords="Anthrax and vaccines">
<pop>Adults and teenagers</pop>
<prob>Anthrax seronegative individuals (>14)</prob>
<int>anthrax vaccine</int>
<comp>Placebo</comp>
<out>Immunogenicity</out>
</query>
<query id="A29.2" before="20081201" keywords="Anthrax and vaccines">
<pop>Adults and teenagers</pop>
<prob>Anthrax seronegative individuals</prob>
<int>anthrax vaccine</int>
<comp>Placebo</comp>
<out>vaccine safety</out>
</query>
<query id="A30.1" before="20081201" keywords="Cystic fibrosis and Pseudomonas aeruginosa infection prevention">
<pop>Different ages</pop>
<prob>Cystic fibrosis</prob>
<int>Pseudomonas aeruginosa vaccines</int>
<comp>Control vaccines</comp>
<out>Pseudomonas aeruginosa</out>
</query>
<query id="A30.2" before="20081201" keywords="Cystic fibrosis and Pseudomonas aeruginosa infection prevention">
<pop>Different ages</pop>
<prob>Cystic fibrosis</prob>
<int>Pseudomonas aeruginosa vaccines</int>
<comp>No intervention</comp>
<out>Pseudomonas aeruginosa</out>
</query>
<query id="A31.1" before="20030301" keywords="vaccine and hepatitis B">
<pop>Adults</pop>
<prob>Health-care workers</prob>
<int>Hepatitis B plasma-derived vaccine</int>
<comp>Placebo</comp>
<out>Hepatitis B events</out>
<dur>maximum follow-up</dur>
</query>
<query id="A31.2" before="20030301" keywords="vaccine and hepatitis B">
<pop>Adults</pop>
<prob>Health-care workers</prob>
<int>Hepatitis B recombinant vaccine</int>
<comp>No intervention</comp>
<out>Hepatitis B events</out>
<dur>maximum follow-up</dur>
</query>
<query id="A32.1" before="20080101" keywords="influenza vaccine and asthma">
<pop>Adults and children</pop>
<prob>Asthma</prob>
<int>Influenza vaccine</int>
<comp>No vaccine</comp>
<out>Asthma exacerbations</out>
<dur>Two weeks</dur>
</query>
<query id="A33.1" before="20070401" keywords="Japanese encephalitis and vaccine">
<pop>Children</pop>
<prob>Never had Japanese encephalitis</prob>
<int>Japanese encephalitis vaccine</int>
<comp>Placebo</comp>
<out>Japanese encephalitis</out>
</query>
<query id="A33.2" before="20070401" keywords="Japanese encephalitis and vaccine">
<pop>Children</pop>
<prob>Never had Japanese encephalitis</prob>
<int>Japanese encephalitis vaccine</int>
<comp>No intervention</comp>
<out>Adverse events</out>
</query>
<query id="A34.1" before="20060401" keywords="malaria and pre-erythrocytic vaccine">
<pop>Any age people</pop>
<prob>malaria infection exposure</prob>
<int>pre-erythrocytic vaccine</int>
<comp>Placebo</comp>
<out>Malaria attack</out>
</query>
<query id="A34.2" before="20060401" keywords="malaria and pre-erythrocytic vaccine">
<pop>Any age people</pop>
<prob>malaria infection exposure</prob>
<int>pre-erythrocytic vaccine</int>
<comp>control vaccine</comp>
<out>Malaria attack</out>
</query>
<query id="A35.1" before="20070101" keywords="smallpox and vaccine">
<pop>Adults and children</pop>
<prob>No previous smallpox infection</prob>
<int>Smallpox vaccine</int>
<comp>Placebo</comp>
<out>Disease prevention</out>
</query>
<query id="A35.2" before="20070101" keywords="smallpox and vaccine">
<pop>Adults and children</pop>
<prob>No previous smallpox infection</prob>
<int>Smallpox vaccine</int>
<comp>Non-smallpox vaccine</comp>
<out>Adverse events</out>
</query>
<query id="A36.1" before="20080701" keywords="Tick-borne encephalitis and vaccine">
<pop>Adults + children</pop>
<prob>Tick-borne viral infection free</prob>
<int>Tick-borne encephalitis vaccine</int>
<comp>Placebo</comp>
<out>Immunogenicity</out>
</query>
<query id="A36.2" before="20080701" keywords="Tick-borne encephalitis and vaccine">
<pop>Adults + children</pop>
<prob>Tick-borne viral infection free</prob>
<int>Tick-borne encephalitis vaccine</int>
<comp>Control vaccines</comp>
<out>Adverse effects</out>
</query>
<query id="A37.1" before="20060901" keywords="male sterilization and vasectomy">
<pop>Adults</pop>
<prob>Males</prob>
<int>vas occlusion vasectomy technique</int>
<comp>conventional vasectomy technique</comp>
<out>azoospermia</out>
</query>
<query id="A37.2" before="20060901" keywords="male sterilization and vasectomy">
<pop>Adults</pop>
<prob>Males</prob>
<int>irrigation with water vasectomy technique</int>
<comp>no irrigation</comp>
<out>time to azoospermia</out>
</query>
<query id="A38.1" before="20030301" keywords="venous thromboembolism and low-molecular-weight heparins and vitamin K antagonists">
<pop>Adults</pop>
<prob>venous thromboembolism (VTE)</prob>
<int>low-molecular-weight heparins</int>
<comp>vitamin K antagonists</comp>
<out>recurrent symptomatic VTE</out>
<dur>3-6 months</dur>
</query>
<query id="A38.2" before="20030301" keywords="venous thromboembolism and low-molecular-weight heparins and vitamin K antagonists">
<pop>Adults</pop>
<prob>venous thromboembolism (VTE)</prob>
<int>low-molecular-weight heparins</int>
<comp>vitamin K antagonists</comp>
<out>Bleeding</out>
<dur>3-6 months</dur>
</query>
<query id="A39.1" before="20070101" keywords="Epilepsy and vitamins">
<pop>Any age individuals</pop>
<prob>Epilepsy</prob>
<int>Vitamine/s + ADEs</int>
<comp>Placebo</comp>
<out>seizure control</out>
</query>
<query id="A39.2" before="20070101" keywords="Epilepsy and vitamins">
<pop>Any age individuals</pop>
<prob>Epilepsy</prob>
<int>Vitamine/s</int>
<comp>Other treatment</comp>
<out>Seizure control</out>
</query>
<query id="A39.3" before="20070101" keywords="Epilepsy and vitamins">
<pop>Any age individuals</pop>
<prob>Epilepsy</prob>
<int>Vitamine/s + ADEs</int>
<comp>Other treatment</comp>
<out>AEDs adverse events</out>
</query>
<query id="A40.1" before="20080401" keywords="Vigabatrin and refractory partial epilepsy">
<pop>All ages</pop>
<prob>Drug-resistant partial epilepsy</prob>
<int>Vigabatrin</int>
<comp>Placebo</comp>
<out>Seizure frequency</out>
</query>
<query id="A40.2" before="20080401" keywords="Vigabatrin and refractory partial epilepsy">
<pop>All ages</pop>
<prob>Drug-resistant partial epilepsy</prob>
<int>Vigabatrin</int>
<comp>Placebo</comp>
<out>treatment withdrawn</out>
</query>
<query id="A41.1" before="20051001" keywords="peripheral neuropathy and vitamin B">
<pop>Adults</pop>
<prob>Alcoholic or diabetic neuropathy</prob>
<int>Vitamin B</int>
<comp>Placebo</comp>
<out>Symptoms improvement</out>
<dur>one month</dur>
</query>
<query id="A41.2" before="20051001" keywords="peripheral neuropathy and vitamin B">
<pop>Adults</pop>
<prob>Alcoholic or diabetic neuropathy</prob>
<int>Vitamin B high dose</int>
<comp>Vitamine B low dose</comp>
<out>Symptoms improvement</out>
<dur>2 weeks</dur>
</query>
<query id="A42.1" before="20090201" keywords="Pneumonia and vitamin C">
<pop>Adults and elderly</pop>
<prob>Pneumonia</prob>
<int>Vitamin C</int>
<comp>Placebo</comp>
<out>Duration of symptoms</out>
<dur>4 weeks - 6 months</dur>
</query>
<query id="A42.2" before="20090201" keywords="Pneumonia and vitamin C">
<pop>Adults and elderly</pop>
<prob>Pneumonia</prob>
<int>Vitamin C</int>
<comp>Placebo</comp>
<out>Mortality</out>
</query>
<query id="A42.3" before="20090201" keywords="Pneumonia and vitamin C">
<pop>Young adults</pop>
<prob>Pneumonia free</prob>
<int>Vitamin C</int>
<comp>With or without Placebo</comp>
<out>Incidence of pneumonia</out>
<dur>6 months</dur>
</query>
<query id="A43.1" before="20090501" keywords="washout and term indwelling urinary catheterization">
<pop>adults</pop>
<prob>long-term indwelling urinary catheterization</prob>
<int>Washout</int>
<comp>No-washout</comp>
<out>mean time to first catheter change</out>
<dur>8 weeks</dur>
</query>
<query id="A43.2" before="20090501" keywords="washout and term indwelling urinary catheterization">
<pop>adults</pop>
<prob>long-term indwelling urinary catheterization</prob>
<int>Saline washout solution</int>
<comp>Acidic washout solution</comp>
<out>Bacteriuria</out>
<dur>12 weeks</dur>
</query>
<query id="A44.1" before="20070701" keywords="Weighted vaginal cones and urinary incontinence">
<pop>Women</pop>
<prob>Stress urinary incontinence</prob>
<int>Weighted Passive vaginal cones</int>
<comp>Weighted Active vaginal cones</comp>
<out>Leakage activity index</out>
</query>
<query id="A44.2" before="20070701" keywords="Weighted vaginal cones and urinary incontinence">
<pop>Women</pop>
<prob>Stress urinary incontinence</prob>
<int>Weighted vaginal cones</int>
<comp>Continence Guard</comp>
<out>Stress Pad test</out>
<dur>6 months</dur>
</query>
<query id="A45.1" before="20060601" keywords="Whole grain foods and type 2 diabetes">
<pop>Adults</pop>
<prob>Obese hyperinsulinemic</prob>
<int>Diet rich in whole-grain foods</int>
<comp>Diet rich in refined grain foods</comp>
<out>change in Insulin sensitivity</out>
<dur>6 weeks</dur>
</query>
<query id="A46.1" before="19990301" keywords="2Forceps vacuum delivery">
<pop>Women</pop>
<prob>Vaginal delivery</prob>
<int>Vacuum extraction</int>
<comp>Forceps</comp>
<out>Maternal trauma</out>
</query>
<query id="A46.2" before="19990301" keywords="Forceps vacuum delivery">
<pop>Women</pop>
<prob>Vaginal delivery</prob>
<int>Vacuum extraction</int>
<comp>Forceps</comp>
<out>Neonatal morbidity</out>
</query>
<query id="A47.1" before="20071001" keywords="Vaginal chlorhexidine and group B streptococcal infection">
<pop>Women</pop>
<prob>colonized with group B beta-hemolytic streptococcus</prob>
<int>chlorhexidine during labor</int>
<comp>Placebo</comp>
<out>GBS colonization in neonates</out>
</query>
<query id="A47.2" before="20071001" keywords="Vaginal chlorhexidine and group B streptococcal infection">
<pop>Women</pop>
<prob>colonized with group B beta-hemolytic streptococcus</prob>
<int>chlorhexidine during labor</int>
<comp>No treatment</comp>
<out>early-onset GBS infection in term neonates</out>
</query>
<query id="A4.1" before="20090901" keywords="blood pressure and potassium-sparing diuretics">
<pop>adults</pop>
<prob>primary hypertension</prob>
<int>Potassium-sparing diuretics</int>
<comp>placebo</comp>
<out>blood-pressure</out>
<dur>3 to 12 weeks</dur>
</query>
<query id="A4.2" before="20090901" keywords="blood pressure and potassium-sparing diuretics">
<pop>adults</pop>
<prob>primary hypertension</prob>
<int>Potassium-sparing diuretics + another class anti-hypertensive drug</int>
<comp>same another class anti-hypertensive drug</comp>
<out>blood-pressure</out>
<dur>3 to 12 weeks</dur>
</query>
<query id="A6.1" before="20090201" keywords="cervical carcinoma and hyperthermia">
<pop>women</pop>
<prob>locally advanced cervical carcinoma</prob>
<int>hyperthermia + radiotherapy</int>
<comp>radiotherapy</comp>
<out>local tumor control</out>
</query>
<query id="A6.2" before="20090201" keywords="cervical carcinoma and hyperthermia">
<pop>women</pop>
<prob>locally advanced cervical carcinoma</prob>
<int>hyperthermia + radiotherapy</int>
<comp>radiotherapy</comp>
<out>treatment related morbidity</out>
</query>
<query id="A6.3" before="20090201" keywords="cervical carcinoma and hyperthermia">
<pop>women</pop>
<prob>locally advanced cervical carcinoma</prob>
<int>hyperthermia + radiotherapy</int>
<comp>radiotherapy</comp>
<out>survival</out>
</query>
<query id="A7.1" before="20090501" keywords="caesarean section and aspiration pneumonitis">
<pop>Women</pop>
<prob>uncomplicated pregnancy</prob>
<int>Intervention prior caesarean section</int>
<comp>No treatment</comp>
<out>Aspiration pneumonitis</out>
</query>
<query id="A8.1" before="20080201" keywords="children with Chronic kidney disease and bone disease">
<pop>Children</pop>
<prob>Chronic kidney disease</prob>
<int>Vitamin D</int>
<comp>Placebo</comp>
<out>bone disease prevention</out>
</query>
<query id="A8.2" before="20080201" keywords="children with Chronic kidney disease and bone disease">
<pop>Children</pop>
<prob>Chronic kidney disease</prob>
<int>Vitamin D</int>
<comp>Placebo</comp>
<out>bone disease improvement</out>
</query>
<query id="A9.1" before="20090201" keywords="Haemodialysis and Central venous catheters and infectious complications">
<pop>Adults</pop>
<prob>Haemodialysis patients with Central venous catheters</prob>
<int>Prophylactic topical antimicrobials</int>
<comp>Topical antiseptics</comp>
<out>Infectious complications prevention</out>
</query>
<query id="A9.2" before="20090201" keywords="Haemodialysis and Central venous catheters and infectious complications">
<pop>Adults</pop>
<prob>Haemodialysis patients with Central venous catheters</prob>
<int>Medicated dressings</int>
<comp>Non-medicated dressings</comp>
<out>Infectious complications prevention</out>
</query>
<query id="C19.1" before="20091101" keywords="Neurodevelopmental disability and polycythemia">
<pop>Post-term, term or late preterm infants</pop>
<prob>Neonatal polycythemia</prob>
<int>Partial exchange transfusion</int>
<comp>Non-treatment</comp>
<out>Developmental delay at 18 months or older</out>
<dur>Long-term</dur>
</query>
<query id="C19.2" before="20091101" keywords="Neurodevelopmental disability and polycythemia">
<pop>Post-term, term or late preterm infants</pop>
<prob>Neonatal polycythemia</prob>
<int>Partial exchange transfusion</int>
<comp>Non-treatment</comp>
<out>Neonatal mortality</out>
</query>
<query id="C19.3" before="20091101" keywords="Neurodevelopmental disability and polycythemia">
<pop>Post-term, term or late preterm infants</pop>
<prob>Neonatal polycythemia</prob>
<int>Partial exchange transfusion</int>
<comp>Non-treatment</comp>
<out>Necrotizing enterocolitis</out>
<dur>Long-term</dur>
</query>
<query id="C20.1" before="20090401" keywords="Treadmill and Parkinson’s disease">
<pop>Patients of all ages</pop>
<prob>Parkinson's disease</prob>
<int>Treadmill training</int>
<comp>No treadmill training</comp>
<out>Gait speed</out>
</query>
<query id="C20.2" before="20090401" keywords="Treadmill and Parkinson’s disease">
<pop>Patients of all ages</pop>
<prob>Parkinson's disease</prob>
<int>Treadmill training</int>
<comp>No treadmill training</comp>
<out>Stride length</out>
</query>
<query id="C20.3" before="20090401" keywords="Treadmill and Parkinson’s disease">
<pop>Patients of all ages</pop>
<prob>Parkinson's disease</prob>
<int>Treadmill training</int>
<comp>No treadmill training</comp>
<out>Walking distance</out>
</query>
<query id="C21.1" before="20090601" keywords="Management and GORD or GERD (American vs European)">
<pop>Adults 14 years and older</pop>
<prob>GORD</prob>
<int>Medical management: proton pump inhibitors/histamine receptor antagonists</int>
<comp>Laparoscopic fundoplication surgery</comp>
<out>Health-related quality of life</out>
<dur>Short-term</dur>
</query>
<query id="C21.2" before="20090601" keywords="Management and GORD or GERD (American vs European)">
<pop>Adults 14 years and older</pop>
<prob>GORD</prob>
<int>Medical management: proton pump inhibitors/histamine receptor antagonists</int>
<comp>Laparoscopic fundoplication surgery</comp>
<out>Cost</out>
<dur>Short and long-term</dur>
</query>
<query id="C21.3" before="20090601" keywords="Management and GORD or GERD (American vs European)">
<pop>Adults 14 years and older</pop>
<prob>GORD</prob>
<int>Medical management: proton pump inhibitors/histamine receptor antagonists</int>
<comp>Laparoscopic fundoplication surgery</comp>
<out>Gastrointestinal Symptom Rating Scale (GSRS)</out>
</query>
<query id="C22.1" before="20091001" keywords="Ports and laparoscopic and cholecystectomy">
<pop>Patients of all ages</pop>
<prob>Gallstones</prob>
<int>Mini-laparoscopic cholecystectomy</int>
<comp>Conventional laparoscopic cholecystectomy</comp>
<out>Bile duct injury</out>
</query>
<query id="C22.2" before="20091001" keywords="Ports and laparoscopic and cholecystectomy">
<pop>Patients of all ages</pop>
<prob>Gallstones</prob>
<int>Mini-laparoscopic cholecystectomy</int>
<comp>Conventional laparoscopic cholecystectomy</comp>
<out>Re-operation</out>
</query>
<query id="C22.3" before="20091001" keywords="Ports and laparoscopic and cholecystectomy">
<pop>Patients of all ages</pop>
<prob>Gallstones</prob>
<int>Mini-laparoscopic cholecystectomy</int>
<comp>Conventional laparoscopic cholecystectomy</comp>
<out>Conversion to open cholecystectomy</out>
</query>
<query id="C23.1" before="20100101" keywords="Acetaminophen and perineal pain">
<pop>Women</pop>
<prob>Perineal pain in the early postpartum period</prob>
<int>Paracetamol (single administration, any dose)</int>
<comp>Placebo</comp>
<out>Adequate pain relief as reported by women</out>
<dur>4 hours</dur>
</query>
<query id="C23.2" before="20100101" keywords="Acetaminophen and perineal pain">
<pop>Women</pop>
<prob>Perineal pain in the early postpartum period</prob>
<int>Paracetamol (single administration, any dose)</int>
<comp>Placebo</comp>
<out>Additional pain relief</out>
<dur>4 hours</dur>
</query>
<query id="C23.3" before="20100101" keywords="Acetaminophen and perineal pain">
<pop>Women</pop>
<prob>Perineal pain in the early postpartum period</prob>
<int>Paracetamol (single administration, any dose)</int>
<comp>Placebo</comp>
<out>Maternal nausea</out>
<dur>4 hours</dur>
</query>
<query id="C1.1" before="20080101" keywords="Osteoarthritis and Acupuncture">
<pop>adults</pop>
<prob>peripheral joint arthritis</prob>
<int>acupuncture</int>
<comp>sham acupuncture</comp>
<out>pain</out>
<dur>short term</dur>
</query>
<query id="C1.2" before="20080101" keywords="Osteoarthritis and Acupuncture">
<pop>adults</pop>
<prob>peripheral joint arthritis</prob>
<int>acupuncture</int>
<comp>sham acupuncture</comp>
<out>pain</out>
<dur>long term</dur>
</query>
<query id="C1.3" before="20080101" keywords="Osteoarthritis and Acupuncture">
<pop>adults</pop>
<prob>peripheral joint arthritis</prob>
<int>acupuncture</int>
<comp>waiting list control</comp>
<out>pain</out>
<dur>short-term</dur>
</query>
<query id="C2.1" before="20090401" keywords="Otitis media and Adenoidectomy">
<pop>children up to 18 yrs of age</pop>
<prob>otitis media</prob>
<int>adenoidectomy with unilateral tympanostomy tube</int>
<comp>unilateral tympanostomy tubes</comp>
<out>resolution otitis media effusion</out>
<dur>6 months</dur>
</query>
<query id="C2.2" before="20090401" keywords="Otitis media and Adenoidectomy">
<pop>children up to 18 yrs of age</pop>
<prob>otitis media</prob>
<int>adenoidectomy with unilateral tympanostomy tube</int>
<comp>unilateral tympanostomy tubes</comp>
<out>resolution otitis media effusion</out>
<dur>12 months</dur>
</query>
<query id="C2.3" before="20090401" keywords="Otitis media and Adenoidectomy">
<pop>children up to 18 yrs of age</pop>
<prob>otitis media</prob>
<int>adenoidectomy with unilateral tympanostomy tube</int>
<comp>unilateral tympanostomy tubes</comp>
<out>hearing loss</out>
<dur>6 months</dur>
</query>
<query id="C3.1" before="20070501" keywords="Amisulpride and Schizophrenia">
<pop>adults</pop>
<prob>schizophrenia</prob>
<int>amisulpride</int>
<comp>olanzapine</comp>
<out>global state: no clinically significant response</out>
</query>
<query id="C3.2" before="20070501" keywords="Amisulpride and Schizophrenia">
<pop>adults</pop>
<prob>schizophrenia</prob>
<int>amisulpride</int>
<comp>olanzapine</comp>
<out>global state: no clinically significant response</out>
<dur>short-term</dur>
</query>
<query id="C3.3" before="20070501" keywords="Amisulpride and Schizophrenia">
<pop>adults</pop>
<prob>schizophrenia</prob>
<int>amisulpride</int>
<comp>olanzapine</comp>
<out>general mental state</out>
<dur>short-term</dur>
</query>
<query id="C4.1" before="20090501" keywords="antenatal and cardiotocography">
<pop>women</pop>
<prob>increased risk of complications at birth</prob>
<int>antenatal cardiotocography</int>
<comp>no antenatal cardiotocography</comp>
<out>perinatal mortality</out>
</query>
<query id="C4.2" before="20090501" keywords="antenatal and cardiotocography">
<pop>women</pop>
<prob>increased risk of complications at birth</prob>
<int>antenatal cardiotocography</int>
<comp>no antenatal cardiotocography</comp>
<out>caesarian section</out>
</query>
<query id="C5.1" before="20090601" keywords="cardiotocography and pregnancy">
<pop>women</pop>
<prob>cesarean section</prob>
<int>antibiotic prophylaxis</int>
<comp>no prophylaxis</comp>
<out>febrile morbidity/fever</out>
</query>
<query id="C5.2" before="20090601" keywords="cardiotocography and pregnancy">
<pop>women</pop>
<prob>cesarean section</prob>
<int>antibiotic prophylaxis</int>
<comp>no prophylaxis</comp>
<out>maternal wound infection</out>
</query>
<query id="C5.3" before="20090601" keywords="cardiotocography and pregnancy">
<pop>women</pop>
<prob>cesarean section</prob>
<int>antibiotic prophylaxis</int>
<comp>no prophylaxis</comp>
<out>maternal endometritis</out>
</query>
<query id="C6.1" before="20090801" keywords="immunotherapy and ovarian cancer">
<pop>women</pop>
<prob>epithelial ovarian cancer</prob>
<int>intravenous monoclonal antibody</int>
<comp>placebo</comp>
<out>Survival (time to relapse)</out>
</query>
<query id="C6.2" before="20090801" keywords="immunotherapy and ovarian cancer">
<pop>women</pop>
<prob>epithelial ovarian cancer</prob>
<int>intravenous monoclonal antibody</int>
<comp>placebo</comp>
<out>humoral immune responses</out>
</query>
<query id="C6.3" before="20090801" keywords="immunotherapy and ovarian cancer">
<pop>women</pop>
<prob>epithelial ovarian cancer</prob>
<int>intradermal peptide pulsed dendritic Cells (vaccine alone)</int>
<comp>single dose of cyclophosphamide prior to first vaccination</comp>
<out>Tumor responses</out>
</query>
<query id="C7.1" before="20090601" keywords="antiviral and hepatitis C and HIV">
<pop>Adults</pop>
<prob>Chronic hepatitis C + stable HIV co-infection</prob>
<int>Peginterferon plus ribavirin</int>
<comp>Interferon plus ribavirin</comp>
<out>Sustained virological response</out>
<dur>24 weeks</dur>
</query>
<query id="C7.2" before="20090601" keywords="antiviral and hepatitis C and HIV">
<pop>Adults</pop>
<prob>Chronic hepatitis C + stable HIV co-infection</prob>
<int>Peginterferon plus ribavirin</int>
<comp>Interferon plus ribavirin</comp>
<out>End of treatment virological response</out>
<dur>24 weeks</dur>
</query>
<query id="C7.3" before="20090601" keywords="antiviral and hepatitis C and HIV">
<pop>Adults</pop>
<prob>Chronic hepatitis C + stable HIV co-infection</prob>
<int>Peginterferon plus ribavirin</int>
<comp>Interferon plus ribavirin</comp>
<out>Mortality</out>
<dur>24 weeks</dur>
</query>
<query id="C8.1" before="20090801" keywords="Ethamsylate and preterm infants">
<pop>Infants</pop>
<prob>Preterm or low birth weight</prob>
<int>Ethamsylate</int>
<comp>Placebo</comp>
<out>Neonatal mortality</out>
<dur>28 days postnatal age</dur>
</query>
<query id="C8.2" before="20090801" keywords="Ethamsylate and preterm infants">
<pop>Infants</pop>
<prob>Preterm or low birth weight</prob>
<int>Ethamsylate</int>
<comp>Placebo</comp>
<out>Mortality to hospital discharge</out>
</query>
<query id="C8.3" before="20090801" keywords="Ethamsylate and preterm infants">
<pop>Preterm infants</pop>
<prob>Preterm or low birth weight</prob>
<int>Ethamsylate</int>
<comp>Placebo</comp>
<out>Neurodevelopmental Disability</out>
<dur>2 years</dur>
</query>
<query id="C24.1" before="20090601" keywords="Planned early birth and PPROM">
<pop>Women</pop>
<prob>Preterm prelabour rupture of the membranes (PPROM) prior to 37 weeks of gestation</prob>
<int>Planned early birth</int>
<comp>Expectant management</comp>
<out>Neonatal infection/sepsis</out>
</query>
<query id="C24.2" before="20090601" keywords="Planned early birth and PPROM">
<pop>Women</pop>
<prob>Preterm prelabour rupture of the membranes (PPROM) prior to 37 weeks of gestation</prob>
<int>Planned early birth</int>
<comp>Expectant management</comp>
<out>Respiratory distress syndrome</out>
</query>
<query id="C24.3" before="20090601" keywords="Planned early birth and PPROM">
<pop>Women</pop>
<prob>Preterm prelabour rupture of the membranes (PPROM) prior to 37 weeks of gestation</prob>
<int>Planned early birth</int>
<comp>Expectant management</comp>
<out>Perinatal mortality</out>
</query>
<query id="C25.1" before="20091201" keywords="Cessation and Smoking">
<pop>Persons of any age</pop>
<prob>Cigarette smoking</prob>
<int>Reduction to quite</int>
<comp>Abrupt quitting</comp>
<out>Abstinence</out>
<dur>6 months or more</dur>
</query>
<query id="C25.2" before="20091201" keywords="Cessation and Smoking">
<pop>Persons of any age</pop>
<prob>Cigarette smoking</prob>
<int>Reduction to quite</int>
<comp>Abrupt quitting</comp>
<out>Cigarettes per day</out>
</query>
<query id="C26.1" before="20080301" keywords="Prevention and Ischemic heart disease">
<pop>Patients of all ages</pop>
<prob>Ischemic heart disease</prob>
<int>Service organization</int>
<comp>Normal care</comp>
<out>Mean systolic blood pressure</out>
<dur>18 months</dur>
</query>
<query id="C26.2" before="20080301" keywords="Prevention and Ischemic heart disease">
<pop>Patients of all ages</pop>
<prob>Ischemic heart disease</prob>
<int>Service organization</int>
<comp>Normal care</comp>
<out>Mean diastolic blood pressure</out>
<dur>18 months</dur>
</query>
<query id="C26.3" before="20080301" keywords="Prevention and Ischemic heart disease">
<pop>Patients of all ages</pop>
<prob>Ischemic heart disease</prob>
<int>Service organization</int>
<comp>Normal care</comp>
<out>Total blood cholesterol within study protocol target level (5.2 mmol/l)</out>
<dur>12 months</dur>
</query>
<query id="C27.1" before="20090201" keywords="Abatacept and rheumatoid arthritis">
<pop>Patients 16 years or older</pop>
<prob>Rheumatoid arthritis</prob>
<int>Abatacept + disease-modifying anti-rheumatic drugs (DMARDs)/biologic</int>
<comp>Placebo + DMARDs/biologic</comp>
<out>American College of Rheumatology (ACR) 50% improvement</out>
<dur>3, 6 and 12 months</dur>
</query>
<query id="C27.2" before="20090201" keywords="Abatacept and rheumatoid arthritis">
<pop>Patients 16 years or older</pop>
<prob>Rheumatoid arthritis</prob>
<int>Abatacept + disease-modifying anti-rheumatic drugs (DMARDs)/biologic</int>
<comp>Placebo + DMARDs/biologic</comp>
<out>Improvement in physical function</out>
<dur>3, 6 and 12 months</dur>
</query>
<query id="C27.3" before="20090201" keywords="Abatacept and rheumatoid arthritis">
<pop>Patients 16 years or older</pop>
<prob>Rheumatoid arthritis</prob>
<int>Abatacept + disease-modifying anti-rheumatic drugs (DMARDs)/biologic</int>
<comp>Placebo + DMARDs/biologic</comp>
<out>Achievement of low disease activity state</out>
<dur>3, 6 and 12 months</dur>
</query>
<query id="C28.1" before="20070301" keywords="Adrenergic and urinary incontinence">
<pop>Women 18 years and older</pop>
<prob>Urinary incontinence</prob>
<int>Adrenergic agonist</int>
<comp>Placebo</comp>