trans interactions QTL

[cora97846]

Hello,
I would like to ask whether interactions QTL mapping can be used for trans QTL analysis, because I only see --mode cis_nominal. Can I change it to --mode trans for trans interaction analysis?
Thank you in advance

[francois-a]

Yes, you can add an interaction term with --mode trans using --interaction.

[cora97846]

Thank you for your answer. Is that what you said?
python3 -m tensorqtl ${plink_prefix_path} ${expression_bed} ${prefix}
--covariates ${covariates_file}
--interaction ${interactions_file}
--best_only
--mode trans
But when I tried to analyze it, I found that the error message kept showing
/var/spool/slurm/d/job485300/slurm_script: line 28: 2678 Killed python3 -m tensorqtl ${plink_prefix_path} ${expression_bed} ${prefix} --covariates ${covariates_file} --interaction ${interactions_file} --best_only --mode trans
slurmstepd: error: Detected 1 oom-kill event(s) in StepId=485300.batch. Some of your processes may have been killed by the cgroup out-of-memory handler.
Although I have increased the memory to 512G, I would like to ask whether trans interaction analysis requires a huge amount of memory.