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3.8.0 - New normal panel flag method (optional)

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@keiranmraine keiranmraine released this 22 Feb 09:58
· 26 commits to dev since this release
  • Adds -noflag option to pindel.pl for use cases where flagging needs to be executed separately or not at all.
  • Add -range option to pindel_np_from_vcf.pl
    • Creates bed.gz using pindel call range instead of legacy gff3.gz
  • Adds new flag FF021, normal panel filtering using pindel call range
    • Legacy normal panel filtering remove variants with any overlap with normal panel, looses larger events that we have more confidence in with longer reads.
    • This is not included by default in any flag set
    • A different normal panel needs to be constructed to use this (bed.gz)
  • Nextflow DSL2 worflows
    • pindel_pl - wraps pindel.pl, subworkflow included for later use.
    • np_generation - Generate a normal panel from a list of input BAMs
      • Handles the complete data generation and conversion to bed/gff3.