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Gene_Signatures.gmt.txt
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Gene_Signatures.gmt.txt
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ESR1_DESMEDT na ESR1 TBC1D9 GATA3 CA12 FOXA1 MYB DNALI1 XBP1 SCUBE2 ERBB4 NAT1 ABAT AGR2 LRBA FBP1 DNAJC12 EVL MKL2 TFF1 CIRBP CYP2B6 TFF3 ZNF552 BBS1 ANXA9 SCCPDH LRIG1 KIAA1467 FAM63A GFRA1 ELOVL5 SSH3 HHAT MREG IRS1 IL6ST MTL5 NME5 MAN2B2 C3orf18 SERPINA5 HEXIM1 IFT88 SLC16A6 ROGDI PDZK1 GPD1L TJP3 TCEAL4 KIF13B COX6C KIAA0040 ELOVL2 C5orf5 TMEM9B CHAD RAB26 REEP5 CCDC56 GLI3 DCI PIGT OVOL2 C14orf79 PGR APBB2 FUT8 SLC27A2 HDAC11 ZNF446 NEDD4L RBKS AKR7A3 SLC22A18 HSD17B4 PIB5PA GALNT7 C16orf45 C1orf21 RPH3AL C20orf23 GLRB CYB5R1 MRPS30 ABCD3 GSTM3 ABCA3 ZNF20 ASAH1 BCAS1 CAMLG CREBL2 TBX3 QDPR ZMYND10 PEX12 MCCC2 SERPINB6 ZNF263 SIDT1 AFTPH SEC14L2 AGTR1 C19orf21 PIGQ HEBP1 PLAT ABLIM3 LASS4 IRX5 REPS2 COASY PTPRT PLA2G10 C9orf7 CD2BP2 NEK4 CTSF TEX264 ABCC8 GOLGA1 ASTN2 ABHD14A EEF1A2 SERPINA3 C5orf3 FAM102A C18orf1 LRRC50 PDCD4 EMP2 PIGV SREBF1 STUB1 RAB11FIP1 PRSS23 ACOX2 NR2E3 MRPS27 HSPB1 SLC9A3R1 COQ6 TTC30A GDF15 OCEL1 EXDL2 ETNK2 E4F1 PEX7 C20orf12 HSPA2 GALNT6 DHRS2 SORD PRR13 PTPN13 EGLN2 C3orf52 UBXD6 APH1B TOM1L1 DHCR24 ZNF281 AREG CITED1 SPR TPSG1 MYLIP ATAD4 EGR3 CAMK2N1 CLGN TOB1 AMIGO2 SURF1 FDXR MST1 ALCAM MIPEP SYNJ2BP NDUFAF1 LRP2 CPB1 GPRC5A GP2 APBB3 UEVLD CBFA2T3 RIC8B MPG UNG2 OVGP1 RLN2 KIAA0753 GSTZ1 TMEM80 TNNT1 RAMP1 RSAD1 ATP9A RAPGEF6 CFB GRIA2 CACNG1 TUFT1 SLC22A4 CIB1 BEX1 PAXIP1 C16orf33 WFDC2 DNAJC1 CLUAP1 MGMT C21orf59 PRKCBP1 DCXR CNNM4 DUSP13 MSX2 CDK5RAP3 ADIPOR2 IER3 C20orf44 F7 TTC12 ZNF226 POLR2L ING2 KCNJ3 SOX12 ACOX3 CCDC19 NDE1 CCRK RNF43 DIO1 DUSP5 ZNF217 C3orf60 CTNND2 ZNF239 SPOP GPR162 SLC9A1 TPD52 SSBP2 PNPO GLS2 MKS1 PLS1 C14orf93 NUBP1 LC38A1 SYT13 EPS15L1 IARS2 BCOR NOS1AP PVALB N6AMT1 WDR25 NARFL
ERBB2_DESMEDT_UP na ERBB2 PERLD1 PSMD3 PNMT GSDML CASC3 LASP1 WIPF2 EPN3 PHB CLCA2 ORMDL2 RAP1GAP CUEDC1 HOXC11 CYP2J2 HGD ABCA12 ATP2C2 ITGA3 CEACAM5 TMEM16K NR1D1
PAM50_PROLIF na BIRC5 CCNB1 CDC20 NUF2 CEP55 KNTC2 MKI67 PTTG1 RRM2 TYMS UBE2C
Immune_ESTIMATE immune signature LCP2 LSP1 FYB PLEK HCK IL10RA LILRB1 NCKAP1L LAIR1 NCF2 CYBB PTPRC IL7R LAPTM5 CD53 EVI2B SLA ITGB2 GIMAP4 MYO1F HCLS1 MNDA IL2RG CD48 AOAH CCL5 LTB GMFG GIMAP6 GZMK LST1 GPR65 LILRB2 WIPF1 CD37 BIN2 FCER1G IKZF1 TYROBP FGL2 FLI1 IRF8 ARHGAP15 SH2B3 TNFRSF1B DOCK2 CD2 ARHGEF6 CORO1A LY96 LYZ ITGAL TNFAIP3 RNASE6 TGFB1 PSTPIP1 CST7 RGS1 FGR SELL MICAL1 TRAF3IP3 ITGA4 MAFB ARHGDIB IL4R RHOH HLA-DPA1 NKG7 NCF4 LPXN ITK SELPLG HLA-DPB1 CD3D CD300A IL2RB ADCY7 PTGER4 SRGN CD247 CCR7 MSN ALOX5AP PTGER2 RAC2 GBP2 VAV1 CLEC2B P2RY14 NFKBIA S100A9 IFI30 MFSD1 RASSF2 TPP1 RHOG CLEC4A GZMB PVRIG S100A8 CASP1 BCL2A1 HLA-E KLRB1 GNLY RAB27A IL18RAP TPST2 EMP3 GMIP LCK IL32 PTPRCAP LGALS9 CCDC69 SAMHD1 TAP1 GBP1 CTSS GZMH ADAM8 GLRX PRF1 CD69 HLA-B HLA-DMA CD74 KLRK1 PTPRE HLA-DRA VNN2 TCIRG1 RABGAP1L CSTA ZAP70 HLA-F HLA-G CD52 CD302 CD27
GEPARSIXTO_IMMUNE na CXCL9 CCL5 CD8A CD80 CXCL13 IGKC CR2 INDO PDCD1 CD247 CTLA4 FOXP3
Teff-high na CD274 IFNG CXCL9
N9831_IMMUNE na KIAA1914 AMICA1 CCL21 CCR4 CD1E CD40LG CXCL12 FYN HLA-DOB IGFBP4 PTGDR PTGER4 TLR10
Stromal_ESTIMATE stromal signature DCN PAPPA SFRP4 THBS2 LY86 CXCL14 FOXF1 COL10A1 ACTG2 APBB1IP SH2D1A SULF1 MSR1 C3AR1 FAP PTGIS ITGBL1 BGN CXCL12 ECM2 FCGR2A MS4A4A WISP1 COL1A2 MS4A6A EDNRA VCAM1 GPR124 SCUBE2 AIF1 HEPH LUM PTGER3 RUNX1T1 CDH5 PIK3R5 RAMP3 LDB2 COX7A1 EDIL3 DDR2 FCGR2B LPPR4 COL15A1 AOC3 ITIH3 FMO1 PRKG1 PLXDC1 VSIG4 COL6A3 SGCD COL3A1 F13A1 OLFML1 IGSF6 COMP HGF GIMAP5 ABCA6 ITGAM MAF ITM2A CLEC7A ASPN LRRC15 ERG CD86 TRAT1 COL8A2 TCF21 CD93 CD163 GREM1 LMOD1 TLR2 ZEB2 C1QB KCNJ8 KDR CD33 RASGRP3 TNFSF4 CCR1 CSF1R BTK MFAP5 MXRA5 ISLR ARHGAP28 ZFPM2 TLR7 ADAM12 OLFML2B ENPP2 CILP SIGLEC1 SPON2 PLXNC1 ADAMTS5 SAMSN1 CH25H COL14A1 EMCN RGS4 PCDH12 RARRES2 CD248 PDGFRB C1QA COL5A3 IGF1 SP140 TFEC TNN ATP8B4 ZNF423 FRZB SERPING1 ENPEP CD14 DIO2 FPR1 IL18R1 HDC TXNDC3 PDE2A RSAD2 ITIH5 FASLG MMP3 NOX4 WNT2 LRRC32 CXCL9 ODZ4 FBLN2 EGFL6 IL1B SPON1 CD200
Stromal_FARMER na DCN CSPG2 CDH11 COL3A1 FAP PEDF FBN1 PDGFRL CTSK HTRA1 ASPN SPARC COL5A2 LOXL1 MMP2 SPON1 SFRP4 ITGBL1 CALD1 COPZ2 MFAP2 ANGPTL2 PLAU COL1A2 LRRC17 C1QTNF3 SNAI2 PCOLCE POSTN ECM2 FBLN1 ADAM12 MMP11 AEBP1 PDGFRB GAS1 COL6A3 RARRES2 COL6A1 TGFB3 NDN C1R LRP1 COL10A1 DPYSL3 OLFML2B MMP14 DACT1 MGC3047 THBS2
Stromal_DESMEDT na PLAU BMP1 MMP14 THY1 COL5A2 ADAM12 ANGPTL2 MFAP2 SERPINH1 COL6A1 ISLR PDLIM7 PARVA OLFML2B TAGLN CTSA PDGFRB MXRA8 OSMR COL3A1 GREM1 FAP DBN1 BICD2 TNFRSF12A VDR SNAI2 EPB41L2 FKBP14 NBL1 CAP1 ATP6V1B2 EPHB4 TRAM2 DDR2 GFPT2 NID1 OFD1 IGSF4 STAB1 TPST2 PPP1R15A PDLIM3 ATPIF1 TRIM33 MMP3 EPYC ANKRD46 CPNE1 BCL3 GLB1 UBL5 ULK1 NOL8 TGFB2 PDGFB BASP1 SDS RPS27A ENC1 AGC1 ZNF518 GPR89A RPL18 MEF2A DNASE1L1 MYO1B JPH2
HALLMARK_TNFA_SIGNALING_VIA_NFKB http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB JUNB CXCL2 ATF3 NFKBIA TNFAIP3 PTGS2 CXCL1 IER3 CD83 CCL20 CXCL3 MAFF NFKB2 TNFAIP2 HBEGF KLF6 BIRC3 PLAUR ZFP36 ICAM1 JUN EGR3 IL1B BCL2A1 PPP1R15A ZC3H12A SOD2 NR4A2 IL1A RELB TRAF1 BTG2 DUSP1 MAP3K8 ETS2 F3 SDC4 EGR1 IL6 TNF KDM6B NFKB1 LIF PTX3 FOSL1 NR4A1 JAG1 CCL4 GCH1 CCL2 RCAN1 DUSP2 EHD1 IER2 REL CFLAR RIPK2 NFKBIE NR4A3 PHLDA1 IER5 TNFSF9 GEM GADD45A CXCL10 PLK2 BHLHE40 EGR2 SOCS3 SLC2A6 PTGER4 DUSP5 SERPINB2 NFIL3 SERPINE1 TRIB1 TIPARP RELA BIRC2 CXCL6 LITAF TNFAIP6 CD44 INHBA PLAU MYC TNFRSF9 SGK1 TNIP1 NAMPT FOSL2 PNRC1 ID2 CD69 IL7R EFNA1 PHLDA2 PFKFB3 CCL5 YRDC IFNGR2 SQSTM1 BTG3 GADD45B KYNU G0S2 BTG1 MCL1 VEGFA MAP2K3 CDKN1A CYR61 TANK IFIT2 IL18 TUBB2A IRF1 FOS OLR1 RHOB AREG NINJ1 ZBTB10 PPAP2B KLF4 CXCL11 SAT1 CSF1 GPR183 PMEPA1 PTPRE TLR2 CXCR7 KLF10 MARCKS LAMB3 CEBPB TRIP10 F2RL1 KLF9 LDLR TGIF1 RNF19B DRAM1 B4GALT1 DNAJB4 CSF2 PDE4B SNN PLEK STAT5A DENND5A CCND1 DDX58 SPHK1 CD80 TNFAIP8 CCNL1 FUT4 CCRL2 SPSB1 TSC22D1 B4GALT5 SIK1 CLCF1 NFE2L2 FOSB PER1 NFAT5 ATP2B1 IL12B IL6ST SLC16A6 ABCA1 HES1 BCL6 IRS2 SLC2A3 CEBPD IL23A SMAD3 TAP1 MSC IFIH1 IL15RA TNIP2 BCL3 PANX1 FJX1 EDN1 EIF1 BMP2 DUSP4 PDLIM5 ICOSLG GFPT2 KLF2 TNC SERPINB8 MXD1
HALLMARK_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_HYPOXIA PGK1 PDK1 GBE1 PFKL ALDOA ENO2 PGM1 NDRG1 HK2 ALDOC GPI MXI1 SLC2A1 P4HA1 ADM P4HA2 ENO1 PFKP AK4 FAM162A PFKFB3 VEGFA BNIP3L TPI1 ERO1L KDM3A CCNG2 LDHA GYS1 GAPDH BHLHE40 ANGPTL4 JUN SERPINE1 LOX GCK PPFIA4 MAFF DDIT4 SLC2A3 IGFBP3 NFIL3 FOS RBPJ HK1 CITED2 ISG20 GALK1 WSB1 PYGM STC1 ZNF292 BTG1 PLIN2 CSRP2 VLDLR JMJD6 EXT1 F3 PDK3 ANKZF1 UGP2 ALDOB STC2 ERRFI1 ENO3 PNRC1 HMOX1 PGF GAPDHS CHST2 TMEM45A BCAN ATF3 CAV1 AMPD3 GPC3 NDST1 IRS2 SAP30 GAA SDC4 STBD1 IER3 PKLR IGFBP1 PLAUR PRKCDBP WISP2 LARGE CCRN4L S100A4 RRAGD ZFP36 EGFR EDN2 IDS CDKN1A RORA DUSP1 MIF PPP1R3C DPYSL4 KDELR3 DTNA ADORA2B HS3ST1 PTRF NR3C1 KLF6 GPC4 CYR61 TNFAIP3 CA12 HEXA BGN PPP1R15A PGM2 PIM1 PRDX5 NAGK CDKN1B BRS3 TKTL1 MT1E ATP7A MT2A SDC3 TIPARP PKP1 ANXA2 PGAM2 DDIT3 PRKCA SLC37A4 CXCR4 EFNA3 CP KLF7 CTGF CHST3 TPD52 LXN B4GALNT2 PPARGC1A BCL2 GCNT2 HAS1 KLHL24 SCARB1 SLC25A1 SDC2 CASP6 VHL FOXO3 PDGFB B3GALT6 SLC2A5 SRPX EFNA1 GLRX CXCR7 PAM TGFBI DCN SIAH2 PLAC8 FBP1 TPST2 PHKG1 MYH9 CDKN1C GRHPR PCK1 INHA HSPA5 NDST2 NEDD4L TPBG XPNPEP1 IL6 SLC6A6 MAP3K1 LDHC AKAP12 TES KIF5A LALBA COL5A1 GPC1 HDLBP ILVBL NCAN TGM2 ETS1 HOXB9 SELENBP1 FOSL2 SULT2B1 TGFB3
HALLMARK_MITOTIC_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE ARHGEF2 CLASP1 KIF11 KIF23 ALS2 ARF6 MYO9B MYH9 TUBGCP3 CKAP5 RACGAP1 PREX1 ARHGEF3 NUMA1 SPTBN1 KIF2C KIF5B TTK APC CEP250 PAFAH1B1 CDC42EP2 KIF3B CCDC88A KIF15 BIRC5 CNTROB NF1 TSC1 CDC27 CNTRL TUBGCP5 KIF4A MAPRE1 FGD6 BRCA2 PLK1 RASA1 NEK2 WASF1 TOP2A TRIO ARHGEF11 KATNB1 PRC1 ANLN CDK5RAP2 SMC3 TUBGCP2 ESPL1 MAP1S ARHGAP27 DOCK4 SAC3D1 INCENP ARHGAP5 GSN NET1 LRPPRC RABGAP1 FLNB ARAP3 FGD4 ABR CENPJ NCK1 CENPF KIF20B WASF2 MYH10 CENPE CYTH2 MID1 KLC1 MARK4 ARL8A CEP57 UXT ARHGAP4 CDC42EP4 SASS6 LATS1 OPHN1 WASL MAP3K11 SOS1 ABL1 TIAM1 KIF1B ITSN1 SHROOM1 NCK2 DLGAP5 BCR RANBP9 EPB41L2 9-Sep KATNA1 TUBD1 TPX2 KIF3C SHROOM2 TUBGCP6 SPTAN1 PALLD ARFIP2 KNTC1 HOOK3 SUN2 MID1IP1 DLG1 FLNA ARHGAP10 CDC42BPA ARHGEF12 MARCKS NIN PCM1 RALBP1 EZR SSH2 CDK1 RAB3GAP1 FARP1 SYNPO RHOF ECT2 EPB41 RAPGEF6 KIF22 PCGF5 STAU1 ARHGDIA AURKA FBXO5 NUSAP1 PXN BCAR1 CD2AP AKAP13 HDAC6 AZI1 LLGL1 ATG4B PCNT ALMS1 CRIPAK KPTN DST KIFAP3 PPP4R2 ARHGAP29 RASAL2 CCNB2 PIF1 RASA2 NEDD9 SMC1A ACTN4 PKD2 CLIP2 CDC42 NDC80 TLK1 TAOK2 TBCD CAPZB DOCK2 CTTN SMC4 ARFGEF1 TUBA4A LMNB1 ABI1 ROCK1 CEP192 BUB1 GEMIN4 PLEKHG2 RICTOR BCL2L11 DYNC1H1 FSCN1 ARHGEF7 DYNLL2 MYO1E BIN1 NOTCH2 RFC1 PDLIM5 RHOT2 SORBS2 CDC42EP1 VCL CLIP1 STK38L YWHAE RAPGEF5 CEP72 CSNK1D
HALLMARK_WNT_BETA_CATENIN_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_WNT_BETA_CATENIN_SIGNALING MYC CTNNB1 JAG2 NOTCH1 DLL1 AXIN2 PSEN2 FZD1 NOTCH4 LEF1 AXIN1 NKD1 WNT5B CUL1 JAG1 MAML1 KAT2A GNAI1 WNT6 PTCH1 NCOR2 DKK4 HDAC2 DKK1 TCF7 WNT1 NUMB ADAM17 DVL2 PPARD NCSTN HDAC5 CCND2 FRAT1 CSNK1E RBPJ FZD8 TP53 SKP2 HEY2 HEY1 HDAC11
HALLMARK_TGF_BETA_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_TGF_BETA_SIGNALING TGFBR1 SMAD7 TGFB1 SMURF2 SMURF1 BMPR2 SKIL SKI ACVR1 PMEPA1 NCOR2 SERPINE1 JUNB SMAD1 SMAD6 PPP1R15A TGIF1 FURIN SMAD3 FKBP1A MAP3K7 BMPR1A CTNNB1 HIPK2 KLF10 BMP2 ENG APC PPM1A XIAP CDH1 ID1 LEFTY2 CDKN1C TRIM33 RAB31 TJP1 SLC20A1 CDK9 ID3 NOG ARID4B IFNGR2 ID2 PPP1CA SPTBN1 WWTR1 BCAR3 THBS1 FNTA HDAC1 UBE2D3 LTBP2 RHOA
HALLMARK_IL6_JAK_STAT3_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_IL6_JAK_STAT3_SIGNALING IL4R IL6ST STAT1 IL1R1 CSF2RB SOCS3 STAT3 OSMR IL2RG IFNGR1 TYK2 IL13RA1 TLR2 IFNGR2 IL10RB IL6 IL1R2 IL3RA IFNAR1 TNFRSF1A MYD88 ACVR1B CSF3R ITGB3 REG1A CXCL1 A2M CSF2RA IL15RA IRF9 PDGFC HAX1 BAK1 EBI3 INHBE CRLF2 TNFRSF1B CD14 PTPN1 PTPN2 IL1B CSF1 IL18R1 TNF PF4 CXCL13 LTBR FAS IL17RA CXCL10 IL9R STAM2 TNFRSF12A STAT2 HMOX1 LEPR CBL CD9 CXCL3 TGFB1 MAP3K8 ITGA4 CD38 JUN SOCS1 ACVRL1 PIM1 TNFRSF21 PIK3R5 GRB2 IRF1 DNTT CSF2 IL2RA PTPN11 IL12RB1 CCR1 CNTFR PLA2G2A CXCL9 CD44 IL7 CXCL11 CCL7 LTB IL17RB CD36
HALLMARK_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR POLR2H POLR2A POLR2G POLR2E POLR2J POLR2F POLR2C POLR2K GTF2H3 POLR2D ERCC3 DDB2 POLR1C XPC PCNA POLR2I SUPT4H1 POLD3 POLR3GL POLR3C GTF2B POLR1D NCBP2 RDBP GTF2F1 ERCC5 LIG1 ERCC1 ERCC4 POLD4 COBRA1 RFC2 ELL TAF10 RRM2B SUPT5H RPA3 SNAPC5 SSRP1 RFC3 RPA2 TCEB3 TAF12 TH1L TAF13 TAF6 TAF9 GTF2A2 VPS37D NME1 RNMT ERCC2 POLE4 VPS37B NT5C3 SNAPC4 AAAS ZNRD1 RFC4 ITPA POM121 BRF2 RFC5 SAC3D1 CLP1 NME4 PRIM1 VPS28 TSG101 USP11 TAF1C TARBP2 POLH CETN2 POLD1 CANT1 PDE4B DGCR8 RAD51 SURF1 PNP ADA NME3 GTF3C5 NT5C AK1 GTF2H1 HCLS1 APRT ERCC8 IMPDH2 POLB SDCBP SF3A3 DAD1 UPF3B GUK1 TP53 ADRM1 SEC61A1 POLA2 FEN1 ZNF707 NUDT9 PDE6G TYMS BCAP31 DDB1 NFX1 RAD52 ADCY6 ARL6IP1 DGUOK POLL SMAD5 MPG DUT POLA1 EIF2C4 RALA ZWINT BCAM TK2 CSTF3 GTF2H5 HPRT1 BOLA2 GPX4 BRP44 CDA THOC4 MRPL40 NPR2 REV3L EDF1 DFNA5 TMED2 STX3 RAE1 UMPS EIF1B AK3 NUDT21 RBX1 SRSF6 GMPR2 DCTN4 COX17 CMPK2 CCNO
HALLMARK_G2M_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT AURKA CCNA2 TOP2A CCNB2 CENPA BIRC5 CDC20 PLK1 TTK PRC1 NDC80 KIF11 NUSAP1 CKS2 KIF2C MKI67 AURKB TPX2 SMC4 BUB1 CENPF RACGAP1 CENPE KIF23 UBE2C MCM6 MCM3 PTTG1 CDK1 KIF4A ESPL1 MAD2L1 NEK2 KIF22 HMMR KPNA2 CDKN3 CDC25A H2AFX CDC25B PLK4 CDC6 CCNF MCM5 LMNB1 E2F3 KIF15 CHEK1 UBE2S WHSC1 HMGB3 DBF4 TACC3 MCM2 CDKN2C CDKN1B FANCC NASP STAG1 GINS2 FBXO5 POLQ EZH2 RAD21 STMN1 SUV39H1 PRIM2 E2F1 CHAF1A NOLC1 GSPT1 BUB3 SMC1A ILF3 CDC7 INCENP CKS1B EXO1 H2AFZ TFDP1 CCND1 KPNB1 HN1 LBR HUS1 KIF20B TOP1 PDS5B SRSF1 STIL ABL1 DTYMK CDC27 BARD1 ATF5 CDC45 ODC1 XPO1 SFPQ TMPO PML BRCA2 CTCF CASC5 SETD8 SLC38A1 TRA2B MYBL2 TROAP PAPD7 CUL3 MAPK14 HIST1H2BK MYC AMD1 CBX1 CHMP1A DKC1 YTHDC1 CCNT1 TGFB1 ATRX LIG3 NUP50 SLC7A5 RBL1 NUMA1 RAD54L EFNA5 PRPF4B UCK2 ARID4A CUL1 UPF1 DR1 MNAT1 SMC2 RBM14 RPA2 SQLE ORC6 CDK4 POLE RASAL2 HOXC10 RPS6KA5 CUL4A SLC7A1 FOXN3 HMGA1 SS18 TRAIP PRMT5 CUL5 DDX39A MARCKS PBK ORC5 SAP30 KATNA1 HNRNPD POLA2 HIRA HIF1A SYNCRIP TLE3 NCL RAD23B E2F2 EGF HMGN2 SRSF10 SNRPD1 CASP8AP2 SMARCC1 SLC12A2 NOTCH2 TNPO2 SMAD3 ZAK HSPA8 G3BP1 PTTG3P DMD MEIS1 HNRNPU SRSF2 MT2A NUP98 EWSR1 KIF5B MTF2 E2F4 BCL3 PURA MEIS2 PAFAH1B1 WRN H2AFV ODF2
HALLMARK_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_APOPTOSIS CASP3 CASP9 DFFA CASP7 CFLAR BIRC3 PMAIP1 CASP8 JUN BCL2L11 MCL1 IL1B SPTAN1 DIABLO BAX BIK IL1A BID CDKN1A GADD45A DDIT3 CDKN1B TNF GSN TNFSF10 CASP6 SQSTM1 FASLG EGR3 CD44 FAS IL18 IGFBP6 PRF1 DAP CCND1 BTG3 F2R SATB1 BNIP3L CASP4 TNFRSF12A CREBBP RHOB GPX3 PDGFRB TSPO CCND2 XIAP TIMP1 CTNNB1 IRF1 HSPB1 ADD1 TIMP2 BTG2 TIMP3 LEF1 CASP1 GPX1 BCL10 IGF2R CDC25B AIFM3 CD38 PPP3R1 HGF CLU ATF3 LGALS3 LUM LMNA GADD45B CDK2 IFNB1 RETSAT SMAD7 SOD1 PTK2 ENO2 HMOX1 IER3 BCL2L10 CD2 GCH1 MMP2 VDAC2 TAP1 PLAT IFNGR1 APP BRCA1 ROCK1 PSEN1 DCN PSEN2 SOD2 BMF EREG KRT18 TGFB2 RELA WEE1 RARA CD14 CD69 PEA15 DNAJC3 CASP2 CTH PLCB2 BMP2 HMGB2 LPPR4 H1F0 TGFBR3 EBP TXNIP ANKH RHOT2 CYLD GSTM1 GSR BGN BCL2L1 GNA15 MGMT PPT1 F2 IL6 SC5DL IFITM3 RNASEL EMP1 CAV1 DNM1L ANXA1 TOP2A ISG20 SLC20A1 MADD PPP2R5B BCAP31 ERBB3 NEDD9 SAT1 PDCD4 BCL2L2 FEZ1 ERBB2 DNAJA1 DAP3 DPYD NEFH PAK1 FDXR GPX4 ETF1 CCNA1 GUCY2D AVPR1A
HALLMARK_NOTCH_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_NOTCH_SIGNALING JAG1 NOTCH3 NOTCH2 APH1A HES1 CCND1 FZD1 PSEN2 FZD7 DTX1 DLL1 FZD5 MAML2 NOTCH1 PSENEN WNT5A CUL1 WNT2 DTX4 SAP30 PPARD KAT2A HEYL SKP1 RBX1 TCF7L2 ARRB1 LFNG PRKCA DTX2 ST3GAL6 FBXW11
HALLMARK_ADIPOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS FABP4 ADIPOQ PPARG LIPE DGAT1 LPL CPT2 CD36 GPAM ADIPOR2 ACAA2 ETFB ACOX1 ACADM HADH IDH1 SORBS1 ACADS UCK1 SCP2 DECR1 CDKN2C TALDO1 TST MCCC1 PGM1 REEP5 BCL2L13 SLC25A10 ME1 PHYH PIM3 YWHAG NDUFAB1 GPD2 ADIG ECHS1 QDPR CS ECH1 SLC25A1 ACADL TOB1 GRPEL1 CRAT GBE1 SDPR SCARB1 PEMT CHCHD10 AK2 APOE UQCR10 TANK ANGPTL4 ACO2 FAH ACLY IFNGR1 SLC5A6 JAGN1 EPHX2 IDH3G GPX3 ELMOD3 ORM1 RETSAT ESRRA HIBCH SUCLG1 STAT5A ITGA7 MRAP PLIN2 CYC1 ALDH2 RNF11 ALDOA SULT1A1 DDT SDHB CD151 SLC27A1 BCKDHA C3 LEP ADCY6 ELOVL6 LTC4S SPARCL1 FAM82A2 MTCH2 ANKRD57 SLC1A5 CMPK1 REEP6 NDUFA5 FZD4 DRAM2 MGST3 ATP1B3 RETN STOM ESYT1 GHITM DNAJC15 GADD45A VEGFB PFKL COQ3 OBFC2A CYP4B1 PPM1B ARAF PTRF COL4A1 IMMT DHRS7 COL15A1 NMT1 COQ5 LAMA4 AGPAT3 BAZ2A IDH3A LIFR PREB PTGER3 GPHN PFKFB3 GPX4 SSPN SQRDL MOSC2 DLD ITIH5 CD302 ATL2 AGPAT6 LPCAT3 TKT UQCRC1 CAT OMD DLAT MRPL15 RIOK3 RTN3 CHUK G3BP2 SDHC SAMM50 ARL4A SNCG PDCD4 COQ9 APLP2 SOD1 PTCD3 PHLDB1 ENPP2 HSPB8 AIFM1 CCNG2 PPP1R15B MDH2 ABCA1 COX7B MYLK COX8A DHRS7B FAM73B MGLL ITSN1 DHCR7 RREB1 CMBL UBC ATP5O PRDX3 DBT NDUFS3 NKIRAS1 RAB34 CIDEA UQCRQ PEX14 BCL6 COX6A1 DNAJB9 MAP4K3 ANGPT1 UBQLN1 NDUFB7 SLC19A1 ABCB8 PQLC3 POR UCP2 UQCR11
HALLMARK_ESTROGEN_RESPONSE_EARLY http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY GREB1 CA12 SLC9A3R1 MYB ANXA9 IGFBP4 SYBU NPY1R PDZK1 NRIP1 MLPH HSPB8 EGR3 KRT19 LRIG1 KDM4B PGR RHOBTB3 TPD52L1 ELOVL2 RET TPBG TFF1 MAPT SCNN1A ABAT FLNB XBP1 CELSR2 RAB31 MYBL1 MREG FAM102A MSMB STC2 FAM134B SIAH2 ZNF185 SLC19A2 SLC1A4 FHL2 BCL2 PMAIP1 AREG OVOL2 TSKU ADCY9 RASGRP1 MUC1 KAZN SLC27A2 FKBP4 CXCL12 TMPRSS3 RARA IL17RB CBFA2T3 TFF3 UGCG CCND1 SLC22A5 WFS1 PTGES WWC1 WISP2 MYC ITPK1 TMEM164 ARL3 MED13L SEMA3B KRT18 SLC16A1 TJP3 SLC26A2 FAIM3 SULT2B1 SNX24 TFAP2C TTC39A GJA1 PRSS23 OLFM1 RAPGEFL1 ASB13 TIPARP ABCA3 FRK DHRS2 AQP3 KCNK15 TGIF2 FOXC1 ELF3 REEP1 PEX11A PODXL KLF4 BAG1 CELSR1 PLA2G16 SLC7A5 MPPED2 TIAM1 CLDN7 MYOF RBBP8 OLFML3 GFRA1 FARP1 SVIL TGM2 DEPTOR CYP26B1 PAPSS2 SLC1A1 DLC1 JAK2 AFF1 KLK10 P2RY2 BLVRB CISH GLA ADD3 PDLIM3 FAM63A FOS KRT8 SLC37A1 B4GALT1 CALCR ESRP2 IGF1R NBL1 SFN OPN3 ABHD2 AR SLC39A6 SYT12 CD44 MED24 BCL11B CANT1 KRT13 KRT15 TOB1 SLC7A2 LAD1 TUBB2B TBC1D30 SEC14L2 ENDOD1 HR SCARB1 NCOR2 RHOD INPP5F PPIF DHRS3 FDFT1 GAB2 UNC119 KLF10 HES1 FKBP5 SLC2A1 AMFR NADSYN1 INHBB BHLHE40 CALB2 FASN CHPT1 MYBBP1A ELOVL5 DYNLT3 ABLIM1 SOX3 SLC24A3 RAB17 MAST4 KCNK5 ELF1 RPS6KA2 ISG20L2 IL6ST SYNGR1 SH3BP5 ALDH3B1 THSD4 CLIC3 NXT1 NAV2 RRP12 ADCY1 DHCR7 MICB AKAP1
HALLMARK_ESTROGEN_RESPONSE_LATE http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE TFF1 SLC9A3R1 TPD52L1 PRSS23 CA12 PDZK1 ANXA9 CELSR2 TJP3 PGR RET MYB TPBG EGR3 ARL3 OLFM1 NPY1R SCNN1A XBP1 AREG IL17RB NRIP1 ASS1 TFF3 FKBP4 SLC27A2 SEMA3B GPER LLGL2 AGR2 KRT19 WISP2 BLVRB FLNB PDCD4 CALCR IGFBP4 DNAJC12 TIAM1 TSPAN13 CXCL12 RAB31 PKP3 CYP26B1 FKBP5 SIAH2 ISG20 TMPRSS3 SERPINA3 WFS1 MAPT PDLIM3 RBBP8 GJB3 PRLR SLC1A4 FOS PLA2G16 SLC7A5 SERPINA5 IMPA2 DHCR7 MYOF CDH1 EMP2 OVOL2 DLG5 SOX3 CHPT1 KLK10 ELOVL5 RAPGEFL1 JAK2 SLC26A2 SLC22A5 ITPK1 PCP4 PAPSS2 NAB2 FAM102A BCL2 LSR CACNA2D2 CA2 ASCL1 ACOX2 CISH GLA PTGES PERP OPN3 KRT13 HSPB8 UGDH CLIC3 KLK11 PLAC1 ABHD2 SCARB1 DCXR CCND1 SFN ABCA3 SULT2B1 CCNA1 STIL MICB ZFP36 CAV1 NBL1 CD44 HR HOMER2 BTG3 GAL ETFB BAG1 FRK SLC16A1 AFF1 TFAP2C IGSF1 HPRT1 CDC6 FARP1 AMFR DHRS2 NXT1 S100A9 SLC29A1 SLC24A3 FOXC1 KIF20A TOB1 FDFT1 DNAJC1 TPSAB1 TSTA3 FGFR3 SGK1 ID2 GALE BATF MAPK13 FABP5 MEST JAK1 CYP4F11 KCNK5 CPE XRCC3 CXCL14 SCUBE2 CDC20 IL6ST GINS2 TRIM29 UNC13B LAMC2 LARGE SLC2A8 PLXNB1 PRKAR2B RPS6KA2 HSPA4L TFPI2 SERPINA1 TNNC1 HMGCS2 ALDH3A2 CD9 IDH2 SORD MDK ALDH3B1 PTGER3 RABEP1 KLF4 PPIF SNX10 METTL3 PLK4 COX6C ST14 NCOR2 MOCS2 NMU TH RNASEH2A CHST8 TST TOP2A CKB LTF DUSP2 PTPN6 ATP2B4 ST6GALNAC2 ADD3 DYNLT3
HALLMARK_ANDROGEN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE KLK3 KLK2 ACSL3 PIAS1 CAMKK2 NKX3-1 TMPRSS2 APPBP2 CENPN BMPR1B MAF FADS1 ZBTB10 HMGCR SPCS3 INSIG1 NGLY1 UBE2J1 ELK4 ABCC4 ELOVL5 ALDH1A3 TARP AZGP1 ABHD2 SAT1 DBI DHCR24 SORD STK39 TPD52 IDI1 B2M MAP7 DNAJB9 FKBP5 HERC3 PGM3 HOMER2 ELL2 UAP1 SEC24D LMAN1 PMEPA1 INPP4B RRP12 SEPP1 NDRG1 KRT19 ITGAV B4GALT1 MAK SPDEF GSR KRT8 LIFR PPAP2A STEAP4 GUCY1A3 SRP19 CCND3 IQGAP2 RAB4A SLC26A2 SMS ZMIZ1 SGK1 MERTK HPGD ANKH GNAI3 SRF SLC38A2 HMGCS1 ARID5B CDC14B TNFAIP8 XRCC5 GPD1L ACTN1 RPS6KA3 TSC22D1 PDLIM5 TMEM50A ADAMTS1 NCOA4 AKAP12 SCD PTK2B CDK6 ADRM1 H1F0 HSD17B14 VAPA CCND1 XRCC6 MYL12A UBE2I PTPN21 AKT1 PA2G4
HALLMARK_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION ARCN1 TMED10 COPB2 RAB14 ATP7A COPB1 LAMP2 EGFR IGF2R COPE PPT1 AP3S1 BET1 CLCN3 AP2S1 CLTC AP2M1 RER1 KIF1B ARF1 OCRL ICA1 MON2 ARFGEF2 TMED2 NAPG TMX1 PAM SCAMP1 SH3GL2 RAB2A COG2 VAMP3 ERGIC3 DOPEY1 VAMP4 VPS4B NAPA GNAS STX7 SEC22B VPS45 STX16 YKT6 SNX2 ARFGEF1 CLTA CLN5 M6PR SGMS1 USO1 TSG101 DNM1L LMAN1 YIPF6 ARFIP1 ANP32E TSPAN8 DST SCRN1 SEC31A VAMP7 SCAMP3 AP2B1 RAB22A AP3B1 TPD52 ATP6V1H GBF1 KRT18 CAV2 ATP1A1 BNIP3 ZW10 GALC ADAM10 RAB5A GOLGA4 SEC24D AP1G1 MAPK1 GOSR2 RPS6KA3 STAM ABCA1 SNAP23 SOD1 GLA ATP6V1B1 STX12 CD63 TOM1L1 SSPN ARFGAP3 RAB9A CTSC
HALLMARK_INTERFERON_ALPHA_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE MX1 ISG15 OAS1 IFIT3 IFI44 IFI35 IRF7 RSAD2 IFI44L IFITM1 IFI27 IRF9 OASL EIF2AK2 IFIT2 CXCL10 TAP1 SP110 DDX60 UBE2L6 USP18 PSMB8 IFIH1 BST2 LGALS3BP ADAR ISG20 GBP2 IRF1 PLSCR1 PSMB9 HERC6 SAMD9 CMPK2 IFITM3 RTP4 STAT2 SAMD9L LY6E IFITM2 PRIC285 CXCL11 TRIM21 PARP14 TRIM26 PARP12 NMI RNF31 HLA-C CASP1 TRIM14 TDRD7 DHX58 PARP9 PNPT1 TRIM25 PSME1 WARS EPSTI1 UBA7 PSME2 B2M TRIM5 C1S LAP3 LAMP3 GBP4 NCOA7 TMEM140 CD74 GMPR PSMA3 PROCR IL7 IFI30 IRF2 CSF1 IL15 CNP FAM46A IL4R FTSJD2 CD47 LPAR6 MOV10 CASP8 TXNIP SLC25A28 SELL TRAFD1 BATF2 RIPK2 CCRL2 NUB1 OGFR FAM125A ELF1
HALLMARK_INTERFERON_GAMMA_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE STAT1 ISG15 IFIT1 MX1 IFIT3 IFI35 IRF7 IFIT2 OAS2 TAP1 EIF2AK2 RSAD2 MX2 IRF1 OAS3 TNFSF10 IRF9 CXCL10 IFI44 BST2 XAF1 SP110 OASL PSMB8 IFI44L IFITM3 DDX60 LGALS3BP GBP4 IRF8 PSMB9 PML IFIH1 UBE2L6 IFI27 ADAR LY6E STAT2 CXCL9 IL10RA PLA2G4A TRIM21 USP18 PTGS2 EPSTI1 C1S DDX58 IL15 NLRC5 NMI IDO1 PSMB10 CXCL11 ITGB7 SAMHD1 HERC6 CMPK2 SAMD9L RTP4 PTPN2 PARP14 TNFAIP2 IFITM2 PLSCR1 SOCS1 CASP1 ICAM1 WARS PSME1 ISG20 IRF2 TRIM14 FCGR1A 1-Mar SOCS3 JAK2 HLA-DMA PARP12 TNFAIP6 TRIM26 VCAM1 CD274 CIITA NAMPT SELP GPR18 FPR1 PRIC285 PSME2 SERPING1 CCL5 RNF31 SOD2 TRIM25 LAP3 PSMA3 RNF213 PELI1 CFB CD86 TXNIP HLA-DQA1 GCH1 PNP CCL7 PTPN6 SPPL2A IL4R PNPT1 DHX58 BTG1 CASP8 IFI30 CCL2 FGL2 CASP7 SECTM1 IL15RA CD40 TRAFD1 HLA-DRB1 GBP6 LCP2 HLA-G MT2A RIPK1 KLRK1 UPP1 PSMB2 TDRD7 HIF1A EIF4E3 VAMP8 PFKP CD38 ZBP1 BANK1 TOR1B RBCK1 PDE4B MVP IL7 BPGM FTSJD2 AUTS2 B2M RIPK2 CD69 MYD88 PSMA2 PIM1 NOD1 CFH TAPBP SLC25A28 PTPN1 TNFAIP3 SSPN NUP93 MTHFD2 CDKN1A IRF4 NFKB1 BATF2 HLA-B LATS2 IRF5 SLAMF7 ISOC1 P2RY14 STAT3 NCOA3 HLA-A IL6 GZMA IFNAR2 CD74 RAPGEF6 CASP4 FAS OGFR ARL4A SRI LYSMD2 CSF2RB ST3GAL5 C1R CASP3 CMKLR1 NFKBIA METTL7B ST8SIA4 XCL1 IL2RB VAMP5 IL18BP ZNFX1 ARID5B APOL6 STAT4
HALLMARK_HEDGEHOG_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_HEDGEHOG_SIGNALING SHH PTCH1 NRCAM NRP1 SCG2 AMOT UNC5C GPR56 HEY1 GLI1 THY1 SLIT1 CDK6 HEY2 NRP2 TLE3 TLE1 L1CAM PLG NKX6-1 NF1 RASA1 ETS2 RTN1 CRMP1 MYH9 VEGFA CELSR1 CNTFR ACHE PML CDK5R1 VLDLR OPHN1 LDB1 DPYSL2
HALLMARK_COMPLEMENT http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT C2 C1S CFB C1R SERPINE1 MMP14 SERPING1 CTSL1 F5 MMP13 F7 CTSS LGMN PLG C1QA CASP1 GZMA ADAM9 CALM3 C1QC TIMP1 DPP4 KLK1 KLKB1 CD59 CR2 MMP15 LAP3 SPOCK2 F10 CTSB SERPINA1 CTSO CD40LG CBLB PDP1 C4BPB PLEK GP9 PLAUR C3 F2 CASP4 STX4 CTSC USP15 CR1 DUSP6 SERPINB2 GPD2 CFH FN1 CD36 CA2 PSMB9 APOBEC3G FCN1 GZMK PDGFB CLU CASP10 LRP1 CTSD S100A9 WAS BRPF3 PLAT CDA MT3 CASP7 PRSS36 PFN1 GZMB RNF4 ZEB1 CASP5 IRF1 PGCP CDK5R1 ATOX1 PIK3CA TMPRSS6 CPM RCE1 CALM1 DOCK9 KYNU RASGRP1 USP14 LCP2 GP1BA KIF2A GNB4 LCK OLR1 PREP SEPX1 LTA4H ZFPM2 LYN ACTN2 SIRT6 APOC1 PRKCD ITGAM DGKH LTF MAFF KCNIP2 PCLO DOCK10 SH2B3 RABIF SRC HPCAL4 CD46 PRDM4 GNAI3 C9 PPP2CB IRF2 FYN JAK2 PLA2G4A PRCP USP8 RHOG L3MBTL4 LAMP2 PIM1 CXCL1 F3 GNAI2 CASP9 XPNPEP1 PLSCR1 IRF7 CD55 HSPA5 GNB2 DYRK2 PLA2G7 S100A12 GRB2 PHEX GNGT2 DOCK4 MMP12 KCNIP3 FDX1 TIMP2 MMP8 FCER1G ZFYVE20 ANXA5 CTSL2 GCA EHD1 PRSS3 COL4A2 CSRP1 PIK3R5 SERPINC1 ANG APOBEC3F GATA3 DUSP5 CASP3 USP16 CP PSEN1 LIPA PCSK9 DGKG GNG2 ME1 GMFB SCG3 PPP4C CCL5 CTSH F8 APOA4 IL6 AKAP10 ERAP2 VCPIP1 HSPA1A RAF1 NOTCH4 ADRA2B CEBPB HNF4A LGALS3 TNFAIP3 CDH13 ITIH1 TFPI2 PIK3CG S100A13
HALLMARK_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE ATF4 HERPUD1 PARN EXOSC4 HSP90B1 XBP1 EXOSC9 HSPA5 ATF3 EXOSC1 EXOSC5 ASNS ARFGAP1 WFS1 SRPRB DNAJB9 TSPYL2 NFYA CALR KHSRP DNAJC3 EXOSC2 NOP14 ATF6 HYOU1 RRP9 NOP56 CXXC1 IGFBP1 CNOT4 DCP2 PDIA6 ATP6V0D1 PREB SEC31A GOSR2 SERP1 NFYB NHP2 DCTN1 SLC7A5 SSR1 EDEM1 EDC4 EIF2AK3 MTHFD2 SRPR NOLC1 ERN1 FKBP14 ZBTB17 WIPI1 YIF1A CCL2 DKC1 EIF4EBP1 EIF4A1 EIF2S1 TATDN2 XPOT LSM4 CHAC1 STC2 PDIA5 OBFC2A LSM1 SDAD1 EIF4A2 EIF4E IARS DDX10 GEMIN4 TARS ALDH18A1 DDIT4 HSPA9 SEC11A EIF4A3 POP4 ERO1L CEBPG BAG3 KDELR3 CEBPB CNOT2 SHC1 SPCS3 H2AFX SLC1A4 RPS14 NPM1 CNOT6 CKS1B PSAT1 EIF4G1 YWHAZ SLC30A5 SKIV2L2 KIF5B DCP1A IFIT1 IMP3 SPCS1 DNAJA4 VEGFA TTC37 TUBB2A FUS EXOSC10 EEF2 EXOC2 PAIP1 BANF1
HALLMARK_PI3K_AKT_MTOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING MAPK8 PIK3R3 GRB2 NFKBIB MAP2K6 MAPK9 AKT1 MAPK1 PLCG1 TRIB3 GSK3B MAP2K3 CDKN1A RAC1 RIPK1 AKT1S1 ACTR2 PRKAR2A YWHAB HRAS PDK1 PIKFYVE TBK1 ACTR3 E2F1 MYD88 ITPR2 SQSTM1 RPS6KA1 PTPN11 MAPKAP1 PLCB1 RAF1 CAMK4 RPTOR CFL1 CDK4 TRAF2 GNGT1 UBE2N ADCY2 CDKN1B VAV3 FGF6 ECSIT RALB ARF1 MKNK1 CDK1 PTEN ARHGDIA ADRBK1 FGF17 DDIT3 IRAK4 TIAM1 CDK2 SFN PRKCB GNA14 EIF4E CLTC TSC2 FGF22 PPP1CA DUSP3 HSP90B1 IL4 STAT2 SLA EGFR PLA2G12A MAPK10 CALR THEM4 RIT1 MKNK2 PPP2R1B CAB39L ARPC3 PITX2 NCK1 IL2RG PFN1 FASLG NOD1 DAPP1 UBE2D3 CAB39 AP2M1 MAP3K7 PRKAG1 CSNK2B PRKAA2 ATF1 SLC2A1 PIN1 TNFRSF1A LCK RPS6KA3 NGF CXCR4 ACACA SMAD2 PAK4
HALLMARK_MTORC1_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING FADS1 DDIT4 CALR HK2 PGK1 SLC7A5 CTSC ACSL3 SLC1A5 M6PR TFRC DDIT3 TMEM97 IFRD1 PLOD2 TUBA4A PSAT1 CORO1A LDHA MTHFD2 FADS2 VLDLR WARS SCD P4HA1 ACTR2 IDH1 SLC2A1 GBE1 SERPINH1 NUPR1 PSMG1 PSPH NAMPT CDKN1A BHLHE40 HSPA9 HSPA5 EGLN3 LGMN PNP XBP1 SLA DDX39A HSPE1 ACLY SLC7A11 SSR1 GLA SQSTM1 PDK1 PSMC2 PRDX1 SERP1 TRIB3 NFIL3 HMGCS1 GOT1 TPI1 ELOVL6 ASNS PSMD14 PSMA4 PPA1 HPRT1 AURKA HMGCR GAPDH DHFR DHCR7 IMMT UCHL5 YKT6 INSIG1 SQLE IGFBP5 IFI30 CYP51A1 FGL2 ENO1 IDI1 CYB5B SHMT2 TXNRD1 G6PD SLC9A3R1 RAB1A EBP PNO1 PIK3R3 ACTR3 LDLR SLC2A3 UBE2D3 ELOVL5 CACYBP EDEM1 ATP6V1D TES TM7SF2 PSMA3 ITGB2 AK4 SLC1A4 TOMM40 SLC6A6 PPIA ADD3 ME1 CCNF SLC37A4 ALDOA BTG2 UFM1 CCNG1 STC1 NMT1 PSMC6 FDXR RRM2 DHCR24 PSMC4 CTH PSME3 CFP POLR3G ACACA QDPR MCM2 PSMD12 SC5DL CANX RPN1 HSPA4 FAM129A TBK1 SEC11A BCAT1 PSMB5 PSMD13 PGM1 PLK1 GLRX COPS5 ETF1 GSK3B NUP205 SORD PHGDH GMPS RRP9 EEF1E1 LTA4H SDF2L1 FKBP2 RDH11 CXCR4 MLLT11 GCLC TCEA1 MAP2K3 HSPD1 SYTL2 MCM4 PPP1R15A USO1 NFKBIB UNG GTF2H1 RPA1 HSP90B1 ERO1L GSR PITPNB EPRS SRD5A1 TUBG1 MTHFD2L ADIPOR2 NUFIP1 CDC25A PDAP1 STARD4 BUB1 ARPC5L GPI EIF2S2 CD9 ATP2A2 GGA2 HMBS RIT1 SKAP2 STIP1 DAPP1 ABCF2 NFYC ATP5G1 PFKL CCT6A
HALLMARK_E2F_TARGETS http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS AURKA BRCA2 CCP110 CENPE CKS2 DCLRE1B DNMT1 DONSON EED GINS1 GINS4 H2AFZ LIG1 MAD2L1 MCM2 MCM4 MCM5 MCM7 MELK MMS22L NAA38 NASP NUDT21 NUP205 ORC6 PCNA PLK4 POLE PRIM2 RAD51AP1 RFC2 RPA2 RPA3 SUV39H1 TMPO UBE2T WDR90 CDK1 MCM3 TOP2A MCM6 BIRC5 CCNB2 RRM2 HMGB2 BUB1B RFC3 EZH2 CHEK1 SMC4 MKI67 CDC20 PLK1 KIF2C DLGAP5 AURKB CDC25A TRIP13 H2AFX HMMR E2F8 BRCA1 MYBL2 POLD1 RACGAP1 CKS1B KPNA2 MSH2 CDKN3 ATAD2 RPA1 STMN1 TIPIN TK1 CDCA8 ESPL1 NCAPD2 RANBP1 MRE11A KIF4A LMNB1 KIF22 UNG SMC1A CCNE1 CDCA3 ASF1B POLA2 TIMELESS HELLS UBE2S PRKDC RAN USP1 SPAG5 POLD3 DUT TACC3 KIF18B CDC25B SRSF1 GINS3 NOLC1 SLBP CHEK2 SPC25 BARD1 DCTPP1 SMC3 RNASEH2A DEK CENPM RAD51C CBX5 RFC1 POLD2 DSCC1 ILF3 DEPDC1 DCK CDKN2C MYC TCF19 RAD1 LBR NBN PTTG1 UBR7 POLE4 TUBG1 CTCF RQCD1 TUBB SMC6 ZW10 PA2G4 SSRP1 NAP1L1 ANP32E HMGB3 IPO7 RAD21 CDK4 CDKN1A BRMS1L CTPS RAD50 TRA2B CSE1L PAICS STAG1 LUC7L3 PPM1D NME1 SRSF2 XPO1 HNRNPD PMS2 ASF1A EXOSC8 MLH1 NUP107 ORC2 TP53 TFRC HMGA1 PSIP1 DDX39A SNRPB CDKN1B MTHFD2 WEE1 PRDX4 PHF5A TBRG4 SHMT1 PRPS1 DIAPH3 NUP153 PSMC3IP XRCC6 PNN HUS1 RBBP7 PDS5B NOP56 MXD3 PPP1R8 GSPT1 CDKN2A AK2 CIT ING3 HN1 POP7 SYNCRIP EIF2S1 LYAR PAN2 SPC24
HALLMARK_MYC_TARGETS_V1 http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1 PCNA PSMD8 PSMD7 SET SNRPA1 RAN SRSF2 G3BP1 STARD7 NPM1 BUB3 EIF3D XPO1 FBL EIF4A1 CANX NAP1L1 CBX3 CCT3 C1QBP U2AF1 UBE2L3 SSBP1 SRSF1 TCP1 MCM2 EIF3B PSMD14 SNRPA PWP1 APEX1 TXNL4A HNRNPR PSMB2 HPRT1 MCM6 NME1 SNRPD1 EEF1B2 HSPD1 CAD RPL18 PGK1 DDX18 RPS2 LDHA RUVBL2 RNPS1 EIF2S1 RANBP1 MCM5 IARS UBE2E1 MYC AP3S1 RFC4 DUT PSMA4 RPS3 SNRPG PHB2 SSB EIF4H SRSF3 CCT4 TFDP1 EIF2S2 CDK4 SNRPD3 PSMD1 GNB2L1 GOT2 PABPC4 CCT5 PRPS2 ACP1 PRPF31 CCT2 KARS DEK EIF4G2 XPOT SRM UBA2 KPNB1 PSMA7 TRA2B COX5A PA2G4 PCBP1 HNRNPA1 CCNA2 PPIA EIF3J ORC2 PSMA2 SYNCRIP HDAC2 LSM2 VBP1 PSMA6 CNBP CDK2 TARDBP NOLC1 GSPT1 HNRNPA2B1 ETF1 RPL6 TOMM70A PTGES3 PSMA1 PSMC6 CTPS HSPE1 FAM120A PPM1G HNRNPD SERBP1 CSTF2 PRDX4 EIF4E ODC1 USP1 RPL22 HNRNPA3 NCBP1 RPLP0 ABCE1 EIF1AX YWHAE MCM7 YWHAQ VDAC1 SMARCC1 SNRPD2 HNRNPU HDDC2 PSMD3 RRM1 SF3A1 LSM7 ERH RPL14 PSMB3 IFRD1 NCBP2 GLO1 NDUFAB1 CUL1 NHP2 CLNS1A TRIM28 RSL1D1 HNRNPC COPS5 XRCC6 SLC25A3 MRPL9 POLE3 POLD2 H2AFZ AIMP2 NOP56 PRDX3 MRPS18B EPRS KPNA2 HSP90AB1 RPL34 SRPK1 MAD2L1 DHX15 MCM4 RPS5 CCT7 HDGF RPS6 SNRPB2 PSMC4 CDC20 TUFM RRP9 CDC45 TYMS ILF2 VDAC3 IMPDH2 SF3B3 NOP16 SRSF7 GNL3 EXOSC7 MRPL23 RAD23B RPS10 PHB DDX21 CYC1 PABPC1
HALLMARK_MYC_TARGETS_V2 http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2 SLC19A1 MRTO4 TMEM97 RRP9 PES1 TFB2M EXOSC5 IPO4 NDUFAF4 NOC4L MYC SRM PA2G4 GNL3 NOLC1 WDR43 RABEPK NOP16 TBRG4 DDX18 NIP7 WDR74 BYSL HSPD1 PLK4 NOP2 PPAN NOP56 RCL1 NPM1 AIMP2 RRP12 PPRC1 TCOF1 MCM5 HK2 CBX3 PLK1 PHB MCM4 CDK4 DUSP2 MYBBP1A UTP20 PRMT3 FARSA MAP3K6 LAS1L PUS1 HSPE1 SLC29A2 DCTPP1 SUPV3L1 SORD IMP4 GRWD1 UNG MPHOSPH10
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION COL3A1 COL5A2 COL5A1 FBN1 COL1A1 FN1 COL6A3 SERPINE1 COL1A2 COL4A1 COL4A2 VCAN IGFBP3 TGFBI SPARC LUM LAMC1 LOX LAMC2 CTGF TAGLN COL7A1 LOXL2 COL6A2 ITGAV THBS2 COL16A1 NNMT TPM1 CDH2 MMP2 COL11A1 THBS1 FAP BGN SERPINH1 FSTL1 POSTN THY1 SPP1 TNC TFPI2 NID2 ITGB5 MMP3 VIM LOXL1 FBLN5 COL12A1 ELN CDH11 COMP SPOCK1 BMP1 IL32 LAMA3 TIMP1 QSOX1 TIMP3 VCAM1 CYR61 EDIL3 CALD1 MAGEE1 FBLN1 SGCB ECM1 LAMA2 FSTL3 TPM2 INHBA DAB2 EMP3 BASP1 ITGA5 MGP VEGFA CXCL1 WNT5A SDC1 PLOD2 PCOLCE GREM1 ITGB1 COL5A3 RHOB HTRA1 FGF2 SNTB1 GADD45A MEST LRRC15 TNFRSF11B CD59 ACTA2 EFEMP2 MATN2 PCOLCE2 SERPINE2 GPC1 ABI3BP FUCA1 SLIT3 LAMA1 PMEPA1 COL8A2 FBN2 IGFBP2 PFN2 SDC4 CD44 GADD45B IL8 GLIPR1 ANPEP LEPRE1 VEGFC MMP14 SGCD PLOD1 MATN3 MYL9 SLC6A8 CALU PRRX1 TNFRSF12A FMOD ID2 GEM PLAUR MYLK TGFB1 SFRP1 PLOD3 IL6 APLP1 FBLN2 MSX1 PTX3 FZD8 JUN FERMT2 DKK1 SNAI2 DST TPM4 DCN GJA1 PMP22 IGFBP4 COPA LRP1 ITGA2 FLNA MFAP5 PTHLH TGFBR3 SFRP4 LGALS1 RGS4 CDH6 SAT1 NT5E DPYSL3 PPIB TGM2 SGCG ITGB3 PDLIM4 CTHRC1 ECM2 CRLF1 AREG IL15 MCM7 GAS1 PRSS2 CADM1 OXTR SCG2 CXCL6 MMP1 TNFAIP3 CAPG CAP2 MXRA5 FOXC2 NTM ENO2 FAS BDNF ADAM12 PVR CXCL12 PDGFRB SLIT2 NOTCH2 GLT25D1 GPX7 WIPF1
HALLMARK_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_INFLAMMATORY_RESPONSE CXCL10 CCL2 CCL5 FPR1 CCL20 IL1A IL8 CCL7 CCL22 CXCL11 CCR7 EDN1 CD40 CXCL9 IL6 IL1B TLR2 IL1R1 CD69 ICAM1 CCRL2 AQP9 EREG C3AR1 GNA15 CMKLR1 PTGER4 LIF IL15 NAMPT OPRK1 ITGB8 PTAFR ADM PLAUR NFKB1 INHBA OSM TNFSF10 TNFSF15 IFNGR2 EMR1 IL12B CSF1 CXCL6 TNFRSF9 LYN ACVR2A LDLR BDKRB1 HRH1 F3 BST2 PTGIR CD55 CALCRL CSF3 GPR132 IL4R NLRP3 IL15RA ADORA2B GCH1 OLR1 PTGER2 CSF3R MYC RELA TNFAIP6 IL7R IL18 GABBR1 CD82 TNFSF9 NMUR1 IL2RB TLR1 LPAR1 IRAK2 RIPK2 MMP14 P2RX7 SLC11A2 SELL P2RY2 ABCA1 FFAR2 PROK2 GNAI3 TACR1 SLC7A1 CDKN1A CYBB TIMP1 HBEGF SCARF1 EBI3 NFKBIA SRI SLC7A2 CCL17 TLR3 APLNR OSMR IL10RA PSEN1 GPR183 ATP2B1 TNFRSF1B BEST1 GPC3 SCN1B ACVR1B HPN SEMA4D KLF6 CD48 CXCR6 SLC1A2 GP1BA TAPBP RGS16 SLAMF1 LCK HIF1A AHR NMI RHOG TPBG NPFFR2 IFNAR1 ICOSLG RASGRP1 IFITM1 KCNJ2 LY6E IL18R1 IL10 KCNA3 HAS2 DCBLD2 LAMP3 VIP CD70 RGS1 SLC31A1 ADRM1 KCNMB2 SERPINE1 MXD1 AXL MEFV PVR CCL24 PDE4B LCP2 PDPN IRF7 MET ATP2A2 SLC31A2 FZD5 ITGA5 SGMS2 MARCO CD14 EIF2AK2 ROS1 ATP2C1 NDP BTG2 MSR1 PTPRE RNF144B PCDH7 SPHK1 IL18RAP RTP4 RAF1 CHST2 ITGB3 KIF1B SELE NOD2 C5AR1 EMP3 CLEC5A TACR3 SLC4A4 MEP1A SELS LTA PIK3R5 STAB1 IRF1 ICAM4 P2RX4 ABI1 CX3CL1 SLC28A2
HALLMARK_FATTY_ACID_METABOLISM http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM ACAA1 ACAA2 ACADL ACADM ACOT8 ACOX1 ACSL1 ALDH3A2 CCDC58 CPT2 CYP4A11 DECR1 ECH1 ECI1 ELOVL5 FABP1 FABP2 HADH HIBCH HMGCL HSD17B11 IDH1 ME1 MGLL MLYCD PCBD1 RETSAT S100A10 SUCLG1 VNN1 EHHADH ALDH9A1 HADHB ECHS1 ACADS CA2 HSD17B10 ALDH1A1 ACADVL HSD17B4 CA4 ADH1C ADH7 PTS MAOA HAO2 HSD17B7 MCEE ACAT2 AUH HPGD FH HMGCS2 ALAD GPD1 ACO2 CBR1 GRHPR ACOT2 G0S2 MDH2 HSP90AA1 BCKDHB UROS YWHAH LDHA CRYZ RDH16 INMT UGDH GSTZ1 IDH3B MDH1 CRAT ETFDH CD36 ECI2 SDHD ACSL5 HSDL2 HMGCS1 SDHC CD1D GCDH GPD2 ALDH3A1 SLC22A5 PDHB TDO2 FASN NBN PSME1 PPARA NCAPH2 BPHL ODC1 CA6 DLD HCCS EPHX1 DLST FMO1 AOC3 UROD CPT1A SETD8 UBE2L6 MIF SUCLG2 CPOX SMS CBR3 NTHL1 CIDEA IDI1 AADAT REEP6 HSPH1 APEX1 NSDHL ADIPOR2 ACSL4 ACSS1 ENO3 IDH3G LGALS1 METAP1 ALDOA ACSM3 LTC4S D2HGDH ADSL SUCLA2 SDHA XIST OSTC GLUL CYP4A22 GABARAPL1 AQP7 CYP1A1 PRDX6 ERP29 H2AFZ GAPDHS DHCR24 GAD2 PTPRG IL4I1 TP53INP2 PDHA1 RAP1GDS1 CEL BLVRA SERINC1 BMPR1B RDH11 ENO2
HALLMARK_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION NDUFS3 UQCRB NDUFS2 SDHA UQCRC1 NDUFA9 NDUFS4 NDUFS1 NDUFA2 NDUFS8 SDHB NNT ATP5O ATP5G3 NDUFS7 ATP5A1 NDUFV1 COX5B UQCRH NDUFA1 ATP5C1 ATP5B COX7B SDHD CYCS NDUFA6 NDUFAB1 COX8A ACO2 ATP5G1 CYC1 NDUFB6 ATP5E COX5A UQCRC2 COX6A1 ATP5D COX6C ATP5J NDUFB3 IDH3B OGDH NDUFB8 SURF1 COX6B1 NDUFB5 NDUFA4 NDUFB1 COX4I1 COX7C UQCRFS1 SDHC ATP6V1F COX7A2 SUCLG1 NDUFS6 NDUFA7 FH NDUFV2 OXA1L NDUFC1 UQCR11 NDUFA5 CS ATP6V1G1 ATP5F1 HCCS HADHB ATP5H PDHA1 NDUFA8 DLD OPA1 SLC25A11 ATP5I PDHB ATP5J2 NDUFB7 IDH2 MTX2 VDAC3 MDH1 ATP5G2 IMMT MDH2 SLC25A3 ATP6V1D VDAC2 ACADM COX7A2L TIMM17A ATP6V1E1 NDUFA3 SLC25A6 IDH3G ACADVL ETFA TIMM9 IDH3A TIMM8B ATP6AP1 TIMM13 UQCRQ ABCB7 VDAC1 ATP5L PHB2 DECR1 SUCLA2 GOT2 DLAT ATP6V1H NDUFB2 FDX1 HADHA ATP6V1C1 MAOB NDUFB4 UQCR10 ETFDH GPX4 PDHX MFN2 AIFM1 ACAA2 ETFB COX11 ECHS1 PMPCA ATP6V0B SLC25A5 DLST COX15 CYB5A ALAS1 SLC25A4 CPT1A SLC25A20 MTRR COX17 CYB5R3 TOMM22 ACAT1 MRPS11 ATP6V0C PDK4 TIMM10 LDHA ECI1 MRPL11 FXN MRPS12 COX10 RHOT1 ACAA1 ACADSB LDHB MRPS30 ATP1B1 BDH2 SLC25A12 TIMM50 MRPL34 ISCA1 MRPL35 IDH1 HSPA9 MRPL15 MRPS15 TOMM70A TCIRG1 ISCU POLR2F NQO2 NDUFC2 MRPS22 POR ATP6V0E1 PHYH BRP44L GPI AFG3L2 HSD17B10 CASP7 PRDX3 MGST3 HTRA2 BCKDHA LRPPRC RETSAT ECH1 RHOT2 BAX MTRF1 GLUD1 SUPV3L1 GRPEL1 PDP1 ALDH6A1 OAT
HALLMARK_GLYCOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS PGK1 ALDOA ENO1 TPI1 PFKP ERO1L ALDOB VEGFA MXI1 PKM2 HK2 LDHA EXT1 SLC25A10 GUSB PFKFB1 PGAM1 PYGB AK4 P4HA1 PMM2 FAM162A SDC1 EGLN3 PC B4GALT7 FBP2 IGFBP3 CHPF B3GAT3 CHST12 HS2ST1 MPI GNPDA1 AKR1A1 PPFIA4 B3GAT1 CHPF2 G6PD MDH2 CHST6 PGLS PGAM2 CHST1 GPC1 TSTA3 ALG1 GFPT1 PRPS1 GOT1 MDH1 SLC35A3 GALK1 EGFR ANGPTL4 CITED2 PLOD2 QSOX1 ME2 SPAG4 P4HA2 GAPDHS ENO2 GOT2 EXT2 SLC25A13 HMMR PDK3 CXCR4 GPC4 ECD GNE B4GALT2 FUT8 MIOX VCAN GPC3 B3GALT6 HSPA5 ME1 ADORA2B UGP2 MIF NANP ZNF292 STC2 TPST1 PGM2 GYS1 TKTL1 TGFA CHST2 PHKA2 STMN1 GALE MET LCT IRS2 POLR3K B4GALT1 EFNA3 LHX9 KDELR3 TALDO1 DPYSL4 VLDLR CD44 AGL SOX9 DDIT4 IDUA CASP6 GLCE COPB2 DSC2 HS6ST2 CDK1 PLOD1 SDC2 GMPPB PAXIP1 NSDHL RARS SLC16A3 GLRX SRD5A3 SDC3 HDLBP COL5A1 CLDN9 TFF3 STC1 KIF20A GYS2 SLC37A4 LHPP SDHC NASP AURKA B3GNT3 ISG20 LDHC ARPP19 CENPA HOMER1 BIK CYB5A HAX1 COG2 IL13RA1 NOL3 CLDN3 AGRN CLN6 TXN PAM CAPN5 PKP2 ABCB6 DCN GMPPA BPNT1 ANG GPR87 GAL3ST1 ALDH7A1 NT5E IDH1 PYGL NDUFV3 NDST3 PPP2CB PSMC4 TPBG TGFBI GALK2 CTH KIF2A CACNA1H ANKZF1 SAP30 RBCK1 ELF3 RPE B4GALT4 DEPDC1 RRAGD IER3 ALDH9A1 DLD MERTK GCLC FKBP4 SOD1 MED24 AK3 XYLT2 ARTN PPIA CHST4
HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY GSR PRDX2 TXNRD1 SOD1 GCLC CAT GPX4 MPO PRDX1 PRDX6 GCLM TXN SOD2 PRDX4 SELS PDLIM1 TXNRD2 HBXIP G6PD MSRA MBP SRXN1 NQO1 OXSR1 GLRX2 HMOX2 FES PFKP NDUFB4 GPX3 SCAF4 CDKN2D MGST1 ABCC1 FTL ATOX1 STK25 EGLN2 ERCC2 SBNO2 JUNB PPP2R4 LSP1 NDUFA6 HHEX GLRX NDUFS2 PRNP IPCEF1
HALLMARK_P53_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY CDKN1A BTG2 MDM2 CCNG1 FAS TOB1 GADD45A PHLDA3 TAP1 CDKN2B SFN ZMAT3 DDB2 EI24 PERP DDIT4 ATF3 BAX SESN1 FDXR PIDD SAT1 CDKN2A AEN PPM1D FOXO3 BTG1 TXNIP SLC19A2 IER3 TP53 NOTCH1 RRAD DCXR NINJ1 FOS S100A10 FBXW7 PLK3 XPC AK1 TRIAP1 BAK1 CCND2 APAF1 PDGFA NDRG1 RALGDS SERPINB5 DGKA CYFIP2 KLF4 IP6K2 ADA TNFSF9 KLK8 PRKAB1 STOM SOCS1 PLK2 CASP1 RCHY1 PCNA RPS27L RB1 PPP1R15A POLH RAB40C ERCC5 CDH13 DDIT3 TGFB1 FUCA1 HIST3H2A TP63 HSPA4L EPHX1 ABHD4 H2AFJ TRAF4 CTSF IER5 TAX1BP3 TSC22D1 RGS16 HRAS PVT1 ZFP36L1 SDC1 WRAP73 RAP2B ADCK3 PLXNB2 HEXIM1 PROCR SPHK1 NOL8 DEF6 SP1 JAG2 CCP110 DRAM1 RPL18 CEBPA KIF13B MXD1 TRAFD1 OSGIN1 ANKRA2 HBEGF RAD51C ITGB4 TRIB3 INHBB VAMP8 VWA5A ABAT CTSD PTPRE HINT1 ALOX15B VDR IKBKAP WWP1 NUPR1 TCN2 CDKN2AIP POM121 ZNF365 EPHA2 JUN MAPKAPK3 SLC7A11 SERTAD3 IRAK1 ABCC5 UPP1 CD81 LIF RPL36 FAM162A RNF19B CDK5R1 STEAP3 PITPNC1 SLC35D1 TPRKB RRP8 IL1A PMM1 TPD52L1 IFI30 GM2A RPS12 EPS8L2 TM4SF1 BLCAP MKNK2 CD82 GNB2L1 ST14 TCHH HDAC3 CCNK RHBDF2 NUDT15 TGFA ISCU LDHB TNNI1 FGF13 RXRA APP F2R CLCA2 CGRRF1 CSRNP2 ACVR1B BMP2 GPX2 KRT17 TM7SF3 ZBTB16 PTPN14 TSPYL2 SLC3A2 S100A4 GLS2 CCND3 PRMT2 NHLH2 BAIAP2 RETSAT LRMP HIST1H1C DNTTIP2 MXD4 SEC61A1 HMOX1 RAD9A
HALLMARK_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_ANGIOGENESIS VCAN POSTN FSTL1 LRPAP1 STC1 LPL VEGFA PF4 THBD FGFR1 TNFRSF21 CCND2 COL5A2 ITGAV SERPINA5 KCNJ8 APP JAG1 COL3A1 SPP1 NRP1 OLR1 PDGFA PTK2 SLCO2A1 PGLYRP1 VAV2 S100A4 MSX1 VTN TIMP1 APOH PRG2 JAG2 LUM CXCL6
HALLMARK_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_COAGULATION F2 PROC C1S MMP14 F10 PLG C1R SERPINE1 SERPING1 C2 F12 CFI MMP2 C3 F9 CTSO TMPRSS6 MMP9 PROZ MMP1 CFB BMP1 VWF FGA F11 THBD FURIN MMP11 F8 LGMN HPN CTSB MBL2 F13B TIMP1 CTSL2 MMP8 A2M MMP10 MASP2 FGG C8A PLAU ADAM9 GSN CAPN2 PLAT FN1 CTSH OLR1 SPARC RGN C8B LAMP2 C9 PROS1 CLU F2RL2 CD9 CFH PREP LTA4H GP9 DUSP14 CTSK GDA CASP9 APOC1 CRIP2 KLK8 SERPINC1 ANXA1 ITIH1 PRSS23 FBN1 MST1 F3 KLF7 CTSE ITGB3 CAPN5 CSRP1 KLKB1 MSRB2 TFPI2 MMP3 MEP1A GP1BA APOA1 SERPINA1 TF PEF1 GNG12 SIRT2 COMP HTRA1 MAFF LRP1 PF4 PGCP MMP15 RABIF HRG C8G APOC2 SERPINB2 RAPGEF3 CPN1 ITGA2 RAC1 DPP4 WDR1 THBS1 FYN PDGFB SH2B2 PECAM1 MMP7 DUSP6 CPB2 S100A13 CFD DCT LEFTY2 ANG C1QA HMGCS2 ISCU PLEK APOC3 P2RY1 USP11 TIMP3 ACOX2 HNF4A S100A1 GNB2 ARF4
HALLMARK_IL2_STAT5_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING SOCS2 CISH PIM1 IL2RA TNFRSF4 SOCS1 TNFRSF9 XBP1 RRAGD HK2 PHLDA1 IL2RB CTLA4 NFIL3 CD83 IKZF2 IL10 TNFRSF18 DHRS3 ECM1 ADAM19 SLC2A3 HIPK2 BATF3 BHLHE40 PTGER2 DENND5A ITIH5 PHTF2 GADD45B NRP1 NCOA3 CD79B AHR TNFRSF1B NDRG1 BCL2L1 GABARAPL1 LIF TIAM1 BMPR2 MAP3K8 RHOB MYC S100A1 METTL20 CAPG ST3GAL4 PENK IRF4 CST7 WLS TLR7 IKZF4 GBP4 RGS16 SPP1 IL13 SLC29A2 NFKBIZ IL4R MXD1 CSF2 FAH CTSZ ITGAE MUC1 MAPKAPK2 TNFRSF21 NT5E FLT3LG CCND2 TRAF1 LCLAT1 IL3RA CYFIP1 BCL2 FGL2 PRNP N6AMT2 PUS1 ITGAV NCS1 DCPS AMACR FAM126B PTH1R ODC1 IGF1R PTCH1 ENO3 CD81 MAFF EMP1 CDKN1C CAPN3 IL1R2 SYT11 TTC39B ANXA4 BATF P4HA1 GPR65 SLC1A5 IGF2R CKAP4 CCR4 CD44 P2RX4 GATA1 KLF6 ARL4A HOPX GPR83 ITGA6 CD48 CCDC164 SELP GLIPR2 SMPDL3A PLSCR1 FURIN SERPINB6 TNFSF11 GPX4 LRRC8C CCNE1 CASP3 SH3BGRL2 SNX9 PLEC BMP2 ICOS ALCAM LTB ENPP1 IL1RL1 MYO1C IFNGR1 PLIN2 IL18R1 AHNAK PRKCH TNFRSF8 SYNGR2 GALM POU2F1 EOMES NOP2 PTRH2 RHOH CDC6 MYO1E CXCL10 SNX14 IRF6 IL10RA MAP6 TNFSF10 SPRED2 SELL SERPINC1 CDCP1 RORA COCH CSF1 F2RL2 UCK2 CA2 IFITM3 UMPS HUWE1 COL6A1 ABCB1 RNH1 IRF8 GUCY1B3 AHCY PRAF2 GSTO1 TWSG1 CDC42SE2 PLAGL1 APLP1 AKAP2 PPAP2A SPRY4 SCN9A SHE PDCD2L CCND3 LRIG1 SWAP70 SLC39A8 RABGAP1L TGM2 PNP AGER ETV4 CD86
HALLMARK_ALLOGRAFT_REJECTION http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION PTPRC IL12B TGFB1 IL12A CD3E CD3D CD28 LYN HCLS1 IL18 CRTAM IFNG CD3G CD86 IL10 UBE2N BCL10 CD4 LCK NCK1 C2 HLA-A ITGB2 HLA-DQA1 CD1D CD80 HLA-DRA THY1 TLR1 HLA-G HLA-DMB IL7 IL4 TNF CD247 IL2 HLA-DMA STAT1 IRF4 SRGN INHBA TLR3 ZAP70 CD74 CD40 TRAF2 B2M BCL3 LTB IFNGR1 CCR5 CD40LG HLA-DOA GLMN IL6 HLA-E CD2 CCL5 FAS FASLG TLR6 PF4 TGFB2 CD79A INHBB ELANE SPI1 MAP3K7 IL15 CTSS CD47 PRF1 IL12RB1 LCP2 SOCS1 CDKN2A STAT4 CD7 HLA-DOB CD8A ICAM1 CCL4 GZMB CSF1 IL11 STAB1 IL2RA NLRP3 CCND3 EIF3A SIT1 IFNAR2 HDAC9 CARTPT TRAT1 CCL22 APBB1 FYB IL1B TIMP1 RPS19 JAK2 KRT1 WARS IFNGR2 CCR2 EREG MMP9 EGFR IL16 CFP WAS ITGAL KLRD1 RARS TLR2 CCND2 IL2RG ETS1 ITK NCR1 MAP4K1 CCL19 PSMB10 RPL39 EIF3J ABCE1 CD8B F2 ELF4 LY86 FCGR2B GBP2 PRKCG RPS9 MTIF2 GZMA AARS CD96 CSK HIF1A CCL2 ICOSLG NPM1 IL4R CCL11 NME1 FLNA GPR65 ACHE EIF3D IGSF6 F2R IL13 TAP1 DARS IRF7 ACVR2A CXCR3 PRKCB CXCL9 PTPN6 NCF4 UBE2D1 LIF CCR1 MBL2 DEGS1 TPD52 AKT1 RIPK2 IKBKB GCNT1 SOCS5 IRF8 TAP2 EIF4G3 ABI1 CCL7 IL2RB BRCA1 FGR IL18RAP MRPL3 CXCL13 CAPG EIF5A RPS3A GALNT1 ST8SIA4 CCL13 RPL3L LY75 TAPBP NOS2 RPL9 BCAT1 IL9 IL27RA DYRK3
HALLMARK_KRAS_SIGNALING_UP http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_UP ANGPTL4 ITGA2 SPRY2 HBEGF RBP4 HSD11B1 ETV4 GLRX DUSP6 SCG5 ETV5 ITGB2 AKT2 PPBP G0S2 GABRA3 IRF8 BIRC3 FGF9 DCBLD2 INHBA TFPI TSPAN1 ADAM8 SLPI PRKG2 MMP11 MMP10 TMEM158 TNFAIP3 PRDM1 GALNT3 ETS1 MMP9 WNT7A IGFBP3 SPP1 ETV1 CLEC4A CCND2 TSPAN7 ITGBL1 EMP1 CDADC1 KIF5C TRIB2 SDCCAG8 PCP4 CFHR2 ALDH1A2 NR0B2 ALDH1A3 AMMECR1 SATB1 GUCY1A3 CSF2 APOD TOR1AIP2 CMKLR1 TMEM176B GPR124 LAPTM5 CD37 CAB39L CIDEA ZNF639 IL1B GYPC LY96 FLT4 SPON1 BMP2 PLEK2 IGF2 NR1H4 SNAP25 ACE PRRX1 C3AR1 TRAF1 TLR8 ID2 TMEM100 PLAUR GADD45G CBX8 SCN1B PTBP2 NAP1L2 AKAP12 PLAT SCG3 ANO1 IL1RL2 CXCL10 ATG10 YRDC HDAC9 PEG3 SEMA3B TNNT2 LIF CFB BTC PPP1R15A PTPRR CCL20 ARG1 RETN KLF4 MMD PDCD1LG2 HIST1H2BB HOXD11 TRIB1 F2RL1 ANXA10 TSPAN13 MTMR10 CFH LAT2 ERO1L RELN KCNN4 TMEM176A MAP4K1 PTGS2 IL33 MAFB LCP1 NGF CA2 SERPINA3 RGS16 CTSS USP12 CPE SPARCL1 ABCB1 USH1C CSF2RA BTBD3 IL2RG DNMBP IL10RA EREG SLMO2 EPHB2 FBXO4 CROT MPZL2 ANKH CBR4 DOCK2 GPRC5B RABGAP1L MALL STRN ST6GAL1 PIGR VWA5A PSMB8 F13A1 NRP1 SOX9 JUP ELTD1 ZNF277 EPB41L3 PCSK1N FUCA1 PLVAP ADAM17 AVL9 ADAMDEC1 HKDC1 MAP7 IL7R RBM4 BPGM ENG GFPT2 PLAU GNG11 PTCD2 MAP3K1 CBL CXCR4 NIN IKZF1 WDR33 MYCN FCER1G PECAM1 FAM190B SNAP91 EVI5 TNFRSF1B GPNMB TPH1
HALLMARK_KRAS_SIGNALING_DN http://www.broadinstitute.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_DN CDH16 SPTBN2 FGFR3 NOS1 PDE6B SIDT1 NTF3 SCN10A TAS2R4 DTNB HTR1D MAST3 SLC6A3 CLDN8 TGM1 PCDHB1 THRB YPEL1 RYR2 GDNF CAMK1D AMBN LFNG SERPINA10 ALOX12B CALCB FGGY SPRR3 ATP6V1B1 EDN1 UPK3B GAMT PRODH RYR1 GPR19 SLC29A3 EDN2 GPRC5C C5 FAM164C EDAR KCNMB1 FAM46C STAG3 KRT4 SLC25A23 INSL5 GP1BA MLL2 ABCG4 MYH7 BRDT PTGFR KCNN1 SEPP1 IFI44L PROP1 LGALS7 BMPR1B PDK2 DCC SNCB COL2A1 UGT2B17 PPYR1 DLK2 WNT16 SLC6A14 ITGB1BP2 SLC12A3 YBX2 CKM CPB1 MAGIX ARHGDIG CALML5 KRT1 MTHFR ABCB11 MYOT CELSR2 KLK7 THNSL2 CHRNG NR4A2 CD40LG KRT13 GP2 CD207 CCR8 ZBTB16 PARK2 CPA2 MEFV CCNA1 SLC38A3 KLK8 CYP39A1 KCNQ2 SLC30A3 CHST2 ITIH3 EGF MSH5 TEX15 CLPS ENTPD7 CLSTN3 CYP11B2 CLDN16 HSD11B2 ADCK3 HNF1A FGF22 TFCP2L1 OXT KCND1 H2AFY2 NRIP2 RGS11 CPEB3 TG PTPRJ NUDT11 FSHB IDUA TNNI3 GTF3C5 TFF2 SSTR4 COPZ2 PDCD1 SLC16A7 KCNE2 MFSD6 KLHDC8A CNTFR IL5 NPHS1 SCGB1A1 CCDC106 PAX3 VPREB1 TSHB CACNA1F AKR1B10 P2RX6 KRT15 PAX4 BTG2 GPR3 GRID2 TCL1A PLAG1 PKP1 IRS4 IL12B EPHA5 SOX10 SNN CACNG1 SPHK2 IGFBP2 CAPN9 TCF7L1 TGFB2 SMPX LYPD3 PNMT SYNPO MX1 IFNG NR6A1 ACTC1 RSAD2 ADRA2C BARD1 HTR1B FGF16 ODZ2 CDKAL1 SHOX2 SGK1 RIBC2 SKIL NGB ASB7 MYO15A SLC5A5 KRT5 ZFP112 TFAP2B CCDC132 CD80 ATP4A ARPP21 SERPINB2 TLX1 EFHD1 P2RY4