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cthoyt committed Jun 30, 2020
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Expand Up @@ -5,7 +5,7 @@ While many roles correspond to how their substituent chemicals affect proteins a
Ying *et al.* [@raw:ying2011] previously described how these correspondences could be theoretically formalized.
This article proposes a concrete schema and axioms through which these roles can be linked to their target entities (Figure {@fig:overview}, right), a suite of open source, reusable curation tools, and ultimately a manually curated database of relationships between chemical roles and their targets.

![Schema for inference of chemicals' relations to targets via roles. Targets may be other chemicals, proteins, protein families, protein complexes, pathways, pathologies, or organisms.](images/figure_1_overview.svg){#fig:overview width="90%"}
![Schema for inference of chemicals' relations to targets via roles. Targets may be other chemicals, proteins, protein families, protein complexes, pathways, pathologies, or organisms.](images/figure_1_overview.svg){#fig:overview width="75%"}

Throughout this article, the term *role* (in the context of the ChEBI ontology) will be used in the colloquial sense described by Batchelor *et al.* [@isbn:9781607505341] rather than the formal sense prescribed by the Basic Formal Ontology [@doi:10.3233/AO-160164; @arxiv:1502.04108].

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