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pmcid: PMC10325730 | ||
image_filename: fimmu-14-1179664-g005.jpg | ||
figure_link: /pmc/articles/PMC10325730/figure/f5/ | ||
number: Figure 5 | ||
figure_title: '' | ||
caption: Significant modules and roles of PPI network (A) The top four key gene modules | ||
identified by MCODE plug-in of Cytoscape. (B) Bubble plots of Gene ontology (GO) | ||
enrichment for modules associated with the biological processes (GO-BP, blue), the | ||
cellular components (GO-CC, red), and the molecular functions (GOMF, green). (C) | ||
Bubble plots of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. | ||
article_title: Exploring the potential common denominator pathogenesis of system lupus | ||
erythematosus with COVID-19 based on comprehensive bioinformatics analysis. | ||
citation: Huiqiong Zeng, et al. Front Immunol. 2023;14:1179664. | ||
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doi: 10.3389/fimmu.2023.1179664 | ||
journal_title: Frontiers in Immunology | ||
journal_nlm_ta: Front Immunol | ||
publisher_name: Frontiers Media S.A. | ||
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keywords: | ||
- bioinformatics | ||
- system lupus erythematosus | ||
- COVID-19 | ||
- diagnostic biomarkers | ||
- immune cells infiltration | ||
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pmcid: PMC10462626 | ||
image_filename: 41598_2023_40404_Fig2_HTML.jpg | ||
figure_link: /pmc/articles/PMC10462626/figure/Fig2/ | ||
number: Figure 2 | ||
figure_title: '' | ||
caption: (A) PPI network of DEGs was established by STRING (http://string-db.org) | ||
and visualized via Cytoscape software (version 3.9.0). The red nodes indicated upregulated | ||
genes and the blue nodes indicated downregulated genes. (B) Top 20 hub genes with | ||
a higher degree of connectivity. (C) KEGG pathway enrichment analysis of the top | ||
20 hub genes. (D) The prognostic value (p < 0.05) of the top 20 hub genes in CRC | ||
patients in the disease-free survival (DFS) curve (GEPIA). (E) The expression of | ||
ORM1 between liver metastases and primary tumors, primary tumors, and normal tissues | ||
of CRC in datasets GSE14297, GSE49355, and GSE81558 respectively. Data are expressed | ||
as mean ± SD. ns p ≥ 0.05, ***p < 0.001, ****p < 0.0001 (unpaired t test or ANOVA). | ||
article_title: Orosomucoid 1 promotes colorectal cancer progression and liver metastasis | ||
by affecting PI3K/AKT pathway and inducing macrophage M2 polarization. | ||
citation: Lei Yue, et al. Sci Rep. 2023;13:14092. | ||
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doi: 10.1038/s41598-023-40404-1 | ||
journal_title: Scientific Reports | ||
journal_nlm_ta: Sci Rep | ||
publisher_name: Nature Publishing Group UK | ||
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keywords: | ||
- Cancer | ||
- Gastrointestinal cancer | ||
- Metastasis | ||
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pmcid: PMC10462740 | ||
image_filename: 41598_2023_40617_Fig3_HTML.jpg | ||
figure_link: /pmc/articles/PMC10462740/figure/Fig3/ | ||
number: Figure 3 | ||
figure_title: '' | ||
caption: 'LAMP1 protein–protein interaction network reveals its role in immune regulation. | ||
(A) KEGG-GSEA enrichment analysis of LAMP1 correlated genes on GSE6575 (upper) and | ||
GSE18123 (lower) datasets. (B) The protein–protein interacting (PPI) network of | ||
LAMP1 was obtained from STRING (string-db.org) and visualized using Cytoscape software | ||
(3.8.4). (C) The top 10 hub-gene was calculated using cytoHubba plugin in software | ||
using Maximal Clique Centrality (MCC) algorithm. (D) PPI network connectivity for | ||
LAMP1 and DEGs genes identified as up-regulated in ASD groups constructed by STRING | ||
(https://string-db.org/). (E) The WikiPathway enrichment analysis according to PPIs | ||
of the STRING enrichment results. (F) Human phenotype prediction of LAMP1 using | ||
Harmonizome database indicating as Z-score. (G) Immune cell enrichment analysis | ||
of GSE6575 using TIMER2.0 and that correlation assay between LAMP1 mRNA expression | ||
associations with neutrophil enrichment content was performed. KEGG: Kyoto Encyclopedia | ||
of Genes and Genomes.' | ||
article_title: LAMP1 as a novel molecular biomarker to predict the prognosis of the | ||
children with autism spectrum disorder using bioinformatics approaches. | ||
citation: Sisi Deng, et al. Sci Rep. 2023;13:14040. | ||
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doi: 10.1038/s41598-023-40617-4 | ||
journal_title: Scientific Reports | ||
journal_nlm_ta: Sci Rep | ||
publisher_name: Nature Publishing Group UK | ||
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keywords: | ||
- Biomarkers | ||
- Autism spectrum disorders | ||
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pmcid: PMC9751040 | ||
image_filename: fimmu-13-1058884-g006.jpg | ||
figure_link: /pmc/articles/PMC9751040/figure/f6/ | ||
number: Figure 6 | ||
figure_title: '' | ||
caption: Screening Hub genes. (A) PPI network diagram obtained after applying the | ||
k-means algorithm based on machine learning to the Co-genes. The four genes in the | ||
lower right-hand corner of the enlarged diagram are CASP1, NLRP3, IL1B, and IL18. | ||
(B) PPI network diagram after processing with Cytoscape software. (C) The Top 11 | ||
hub genes are filtered using the Degree algorithm under the CytoHubba package condition. | ||
article_title: SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in | ||
RA patients through pyroptosis. | ||
citation: Qingcong Zheng, et al. Front Immunol. 2022;13:1058884. | ||
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doi: 10.3389/fimmu.2022.1058884 | ||
journal_title: Frontiers in Immunology | ||
journal_nlm_ta: Front Immunol | ||
publisher_name: Frontiers Media S.A. | ||
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keywords: | ||
- SARS-CoV-2 | ||
- COVID-19 | ||
- rheumatoid arthritis | ||
- pyroptosis | ||
- caspase-1 | ||
- minocycline | ||
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https://www.ncbi.nlm.nih.gov/pmc/?term=(network-OR-PPI+cytoscape)+AND+(2023/07/01[PUBDATE]+%3A+3000/01/01[PUBDATE])&report=imagesdocsum&dispmax=100 | ||
https://www.ncbi.nlm.nih.gov/pmc/?term=(network-OR-PPI+cytoscape)+AND+(2023/08/01[PUBDATE]+%3A+3000/01/01[PUBDATE])&report=imagesdocsum&dispmax=100 | ||
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terms: | ||
- network OR PPI | ||
- cytoscape | ||
last_run: 2023/08/01 | ||
last_run: 2023/09/01 | ||
date_range: ~ |