diff --git a/python_modules/automation/automation/docker/images/dagster-celery-k8s-editable/Dockerfile b/python_modules/automation/automation/docker/images/dagster-celery-k8s-editable/Dockerfile
index e98552cd8bdc6..c6e0f61c2427a 100644
--- a/python_modules/automation/automation/docker/images/dagster-celery-k8s-editable/Dockerfile
+++ b/python_modules/automation/automation/docker/images/dagster-celery-k8s-editable/Dockerfile
@@ -4,9 +4,8 @@ FROM "${BASE_IMAGE}"
 ARG DAGSTER_VERSION
 
 COPY build_cache/ /
-ENV VIRTUAL_ENV=/usr/local
 RUN pip install -U uv
-RUN uv pip install \
+RUN python -m uv pip install \
     -e dagster \
     -e dagster-pipes \
     -e dagster-graphql \
diff --git a/python_modules/automation/automation/docker/images/dagster-celery-k8s/Dockerfile b/python_modules/automation/automation/docker/images/dagster-celery-k8s/Dockerfile
index 600c1b09df192..1778af2e83cce 100644
--- a/python_modules/automation/automation/docker/images/dagster-celery-k8s/Dockerfile
+++ b/python_modules/automation/automation/docker/images/dagster-celery-k8s/Dockerfile
@@ -5,9 +5,8 @@ ARG DAGSTER_VERSION
 
 # All packages are hard-pinned to `dagster`, so setting the version on just `DAGSTER` will ensure
 # compatible versions.
-ENV VIRTUAL_ENV=/usr/local
 RUN pip install -U uv
-RUN uv pip install \
+RUN python -m uv pip install \
     dagster==${DAGSTER_VERSION} \
     dagster-azure \
     dagster-postgres \
diff --git a/python_modules/automation/automation/docker/images/dagster-k8s-editable/Dockerfile b/python_modules/automation/automation/docker/images/dagster-k8s-editable/Dockerfile
index 2eb228c80cae4..afcf20b2a5f3e 100644
--- a/python_modules/automation/automation/docker/images/dagster-k8s-editable/Dockerfile
+++ b/python_modules/automation/automation/docker/images/dagster-k8s-editable/Dockerfile
@@ -4,9 +4,8 @@ FROM "${BASE_IMAGE}"
 ARG DAGSTER_VERSION
 
 COPY build_cache/ /
-ENV VIRTUAL_ENV=/usr/local
 RUN pip install -U uv
-RUN uv pip install \
+RUN python -m uv pip install \
     -e dagster \
     -e dagster-pipes \
     -e dagster-graphql \
diff --git a/python_modules/automation/automation/docker/images/dagster-k8s/Dockerfile b/python_modules/automation/automation/docker/images/dagster-k8s/Dockerfile
index 73ddf2361f97f..99074968bcc84 100644
--- a/python_modules/automation/automation/docker/images/dagster-k8s/Dockerfile
+++ b/python_modules/automation/automation/docker/images/dagster-k8s/Dockerfile
@@ -5,9 +5,8 @@ ARG DAGSTER_VERSION
 
 # All packages are hard-pinned to `dagster`, so setting the version on just `DAGSTER` will ensure
 # compatible versions.
-ENV VIRTUAL_ENV=/usr/local
 RUN pip install -U uv
-RUN uv pip install \
+RUN python -m uv pip install \
     dagster==${DAGSTER_VERSION} \
     dagster-azure \
     dagster-postgres \
diff --git a/python_modules/automation/automation/docker/images/user-code-example/Dockerfile b/python_modules/automation/automation/docker/images/user-code-example/Dockerfile
index 8e196d22e5a9a..2aad73da86745 100644
--- a/python_modules/automation/automation/docker/images/user-code-example/Dockerfile
+++ b/python_modules/automation/automation/docker/images/user-code-example/Dockerfile
@@ -5,9 +5,8 @@ ARG DAGSTER_VERSION
 
 # All packages are hard-pinned to `dagster`, so setting the version on just `DAGSTER` will ensure
 # compatible versions.
-ENV VIRTUAL_ENV=/usr/local
 RUN pip install -U uv
-RUN uv pip install \
+RUN python -m uv pip install \
     dagster==${DAGSTER_VERSION} \
     dagster-postgres \
     dagster-aws \
diff --git a/python_modules/dagster-test/Dockerfile b/python_modules/dagster-test/Dockerfile
index 975b1ab0e759a..4cbf7918c3c74 100644
--- a/python_modules/dagster-test/Dockerfile
+++ b/python_modules/dagster-test/Dockerfile
@@ -12,11 +12,10 @@ ENV DAGSTER_DISABLE_TELEMETRY=true
 # This makes sure that logs show up immediately instead of being buffered
 ENV PYTHONUNBUFFERED=1
 
-ENV VIRTUAL_ENV=/usr/local
 RUN pip install -U uv
 # dagster-celery specified twice to deal with pip resolution in pip 20.3.3 when only
 # extras are specified
-RUN uv pip install \
+RUN python -m uv pip install \
     -e modules/dagster \
     -e modules/dagster-graphql \
     -e modules/dagster-celery \