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update tmcf files
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spiekos authored Jul 17, 2024
1 parent 7b953bf commit 26c60d4
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Showing 7 changed files with 104 additions and 50 deletions.
30 changes: 17 additions & 13 deletions scripts/biomedical/PharmGKB/tMCFs/chemicals.tmcf
Original file line number Diff line number Diff line change
@@ -1,41 +1,45 @@
Node: E:chemicals->E1
typeOf: dcs:AnatomicalTherapeuticChemicalCode
dcid: C:chemicals->ATC
dcid: C:chemicals->atcCodes

Node: E:chemicals->E2
typeOf: dcs:MeSHConcept
dcid: C:chemicals->MeSH
dcid: C:chemicals->dcid_MeSHConcept

Node: E:chemicals->E3
typeOf: schema:Drug
typeOf: dcs:MeSHDescriptor
dcid: C:chemicals->dcid_MeSHDescriptor

Node: E:chemicals->E4
typeOf: dcs:ChemicalCompound
dcid: C:chemicals->dcid
name: C:chemicals->Name
atcCode: E:chemicals->E1
bindingDBID: C:chemicals->BindingDB
chebiID: C:chemicals->ChEBI
chemblID: C:chemicals->ChEMBL
chemicalAbstractServiceID: C:chemicals->CAS
clinicalAnnotationCount: C:chemicals->Clinical Annotation Count
clinicalAnnotationCount: C:chemicals->clinicalAnnotationCount
drugBankID: C:chemicals->DrugBank
drugBankMetaboliteID: C:chemicals->DrugBank Metabolite
drugBankMetaboliteID: C:chemicals->drugBankMetabolite
drugBrandMixture: C:chemicals->brandMixture
drugGenericName: C:chemicals->genericName
drugTradeName: C:chemicals->tradeName
drugType: C:chemicals->Type
geneticVariantAnnotationCount: C:chemicals->Variant Annotation Count
geneticVariantAnnotationCount: C:chemicals->variantAnnotationCount
humanMetabolomeDatabaseID: C:chemicals->HMDB
inChIKey: C:chemicals->InChI
medicalSubjectHeadingID: E:chemicals->E2
medicalSubjectHeadingID: E:chemicals->E3
medicalDictionaryForRegulatoryActivitiesId: C:chemicals->MedDRA
metabolicPathwayCount: C:chemicals->Pathway Count
metabolicPathwayCount: C:chemicals->pathwayCount
nationalClinicalTrialNumber: C:chemicals->ClinicalTrials.gov
nationalDrugFileReferenceTerminologyCode: C:chemicals->NDF-RT
pharmGKBID: C:chemicals->pharmGKBID
pubChemCompoundID: C:chemicals->PubChem Compound
pubChemCompoundID: C:chemicals->PubChem Compound Identifiers
pubChemSubstanceID: C:chemicals->PubChem Substance
rxConceptUniqueId: C:chemicals->RxNorm Identifiers
pubChemCompoundID: C:chemicals->pubChemCID
pubChemSubstanceID: C:chemicals->pubChemSubstance
rxConceptUniqueId: C:chemicals->rxNormID
simplifiedMolecularInputLineEntrySystem: C:chemicals->SMILES
topClinicalAnnotationLevel: C:chemicals->Top Clinical Annotation Level
topClinicalAnnotationLevel: C:chemicals->topClinicalAnnotationLevel
url: C:chemicals->URL
veryImportantPharmacogeneCount: C:chemicals->VIP Count
veryImportantPharmacogeneCount: C:chemicals->vipCount
47 changes: 25 additions & 22 deletions scripts/biomedical/PharmGKB/tMCFs/drugs.tmcf
Original file line number Diff line number Diff line change
@@ -1,12 +1,16 @@
Node: E:drugs->E1
typeOf: dcs:AnatomicalTherapeuticChemicalCode
dcid: C:drugs->ATC
dcid: C:drugs->atcCodes

Node: E:drugs->E2
typeOf: dcs:MeSHConcept
dcid: C:drugs->MeSH
dcid: C:drugs->dcid_MeSHConcept

Node: E:drugs->E3
typeOf: dcs:MeSHDescriptor
dcid: C:drugs->dcid_MeSHDescriptor

Node: E:drugs->E4
typeOf: schema:Drug
dcid: C:drugs->dcid
name: C:drugs->Name
Expand All @@ -17,41 +21,40 @@ chebiID: C:drugs->ChEBI
chemblID: C:drugs->ChEMBL
chemicalAbstractServiceID: C:drugs->CAS
chemSpiderID: C:drugs->ChemSpider
clinicalAnnotationCount: C:drugs->Clinical Annotation Count
dailyMedSetId: C:drugs->FDA Drug Label at DailyMed
dosageGuideline: C:drugs->Dosing Guideline
clinicalAnnotationCount: C:drugs->clinicalAnnotationCount
dailyMedSetId: C:drugs->dailyMedFdaDrugLabel
dosageGuideline: C:drugs->dosingGuideline
dosageGuidelineSource: C:drugs->dosingGuidelineSource
drugBankID: C:drugs->DrugBank
drugBrandMixture: C:drugs->brandMixture
drugGenericName: C:drugs->genericName
drugHasPrescribingInfo: C:drugs->FDA Label has Prescribing Info
drugHasPrescribingInfo: C:drugs->hasFdaPrescribingInfo
drugHasRxAnnotation: C:drugs->Has Rx Annotation
drugLabelHasDosingInformation: C:drugs->Label Has Dosing Info
drugLabelHasDosingInformation: C:drugs->hasDosingInfo
drugTradeName: C:drugs->tradeName
drugType: C:drugs->Type
fdaTopPharmacogeneticLevel: C:drugs->Top FDA Label Testing Level
geneticVariantAnnotationCount: C:drugs->Variant Annotation Count
fdaTopPharmacogeneticLevel: C:drugs->topFdaTestingLevel
geneticVariantAnnotationCount: C:drugs->variantAnnotationCount
humanMetabolomeDatabaseID: C:drugs->HMDB
inChIKey: C:drugs->InChI
iupharLigandID: C:drugs->IUPHAR Ligand
keggCompoundID: C:drugs->KEGG Compound
keggDrugID: C:drugs->KEGG Drug
iupharLigandID: C:drugs->iupharLigand
keggCompoundID: C:drugs->keggCompound
keggDrugID: C:drugs->keggDrug
medicalSubjectHeadingID: E:drugs->E2
medicalSubjectHeadingID: E:drugs->E3
medicalDictionaryForRegulatoryActivitiesId: C:drugs->MedDRA
metabolicPathwayCount: C:drugs->Pathway Count
metabolicPathwayCount: C:drugs->pathwayCount
nationalClinicalTrialNumber: C:drugs->ClinicalTrials.gov
nationalDrugFileReferenceTerminologyCode: C:drugs->NDF-RT
pharmacogeneticAssociation: C:drugs->FDA_PGx_Association
pharmGKBID: C:drugs->pharmGKBID
pkgbTags: C:drugs->PharmGKB Tags
pubChemCompoundID: C:drugs->PubChem Compound
pubChemCompoundID: C:drugs->PubChem Compound Identifiers
pubChemSubstanceID: C:drugs->PubChem Substance
rxConceptUniqueId: C:drugs->RxNorm Identifiers
pubChemCompoundID: C:drugs->pubChemCID
pubChemSubstanceID: C:drugs->pubChemSubstance
rxConceptUniqueId: C:drugs->rxNormID
rxConceptUniqueId: C:drugs->RxNorm
simplifiedMolecularInputLineEntrySystem: C:drugs->SMILES
topClinicalAnnotationLevel: C:drugs->Top Clinical Annotation Level
topCpicLevel: C:drugs->Top CPIC Pairs Level
topPharmacogeneticLevel: C:drugs->Top Any Drug Label Testing Level
topClinicalAnnotationLevel: C:drugs->topClinicalAnnotationLevel
topCpicLevel: C:drugs->topCpicPairsLevel
topPharmacogeneticLevel: C:drugs->topAnyDrugLabelTestingLevel
url: C:drugs->URL
veryImportantPharmacogeneCount: C:drugs->VIP Count
veryImportantPharmacogeneCount: C:drugs->vipCount
22 changes: 12 additions & 10 deletions scripts/biomedical/PharmGKB/tMCFs/genes.tmcf
Original file line number Diff line number Diff line change
Expand Up @@ -3,36 +3,38 @@ typeOf: dcs:GenomicCoordinates
dcid: C:genes->genomeCoordDcid38
name: C:genes->genomeCoordName38
chrom: C:genes->Chromosome
chromStart: C:genes->Chromosomal Start - GRCh38
chromEnd: C:genes->Chromosomal Stop - GRCh38
chromStart: C:genes->grCh38Start
chromEnd: C:genes->grCh38Stop
inGenomeAssembly: C:genes->GenomeAssembly38

Node: E:genes->E2
typeOf: dcs:GenomicCoordinates
dcid: C:genes->genomeCoordDcid37
name: C:genes->genomeCoordName37
chrom: C:genes->Chromosome
chromStart: C:genes->Chromosomal Start - GRCh37
chromEnd: C:genes->Chromosomal Stop - GRCh37
chromStart: C:genes->grCh37Start
chromEnd: C:genes->grCh37Stop
inGenomeAssembly: C:genes->GenomeAssembly37

Node: E:genes->E3
typeOf: dcs:Gene
dcid: C:genes->dcid
name: C:genes->Name
alternateGeneSymbol: C:genes->Alternate Symbols
comparativeToxicogenomicsDBID: C:genes->Comparative Toxicogenomics Database
alternateGeneSymbol: C:genes->alternateSymbols
comparativeToxicogenomicsDBID: C:genes->comparativeToxicogenomicsDatabase
ensemblID: C:genes->ensemblID
ensemblID: C:genes->Ensembl
genAtlasID: C:genes->GenAtlas
geneCardID: C:genes->GeneCard
geneSymbol: C:genes->Symbol
hasCpicDosingGuideline: C:genes->Has CPIC Dosing Guideline
hasGeneticVariantAnnotation: C:genes->Has Variant Annotation
hasCpicDosingGuideline: C:genes->hasCpicDosingGuideline
hasGeneticVariantAnnotation: C:genes->hasVariantAnnotation
hasGenomicCoordinates: E:genes->E1
hasGenomicCoordinates: E:genes->E2
hgncID: C:genes->hgncID
hgncID: C:genes->HGNC
isVeryImportantPharmacogene: C:genes->Is VIP
ncbiGeneID: C:genes->NCBI Gene
isVeryImportantPharmacogene: C:genes->isVIP
ncbiGeneID: C:genes->ncbiGene
ncbiGeneID: C:genes->ncbiGeneID
pharmGKBID: C:genes->pharmGKBID
synonym: C:genes->synonyms
10 changes: 8 additions & 2 deletions scripts/biomedical/PharmGKB/tMCFs/phenotypes.tmcf
Original file line number Diff line number Diff line change
@@ -1,7 +1,13 @@
Node: E:phenotypes->E1
typeOf: dcs:MeSHDescriptor
dcid: C:phenotypes->MeSHDcid
nationalDrugFileReferenceTerminologyCode: C:phenotypes->NDFRT
dcid: C:phenotypes->dcid_mesh
name: C:phenotypes->Name
medicalDictionaryForRegulatoryActivitiesId: C:phenotypes->MedDRA
medicalSubjectHeadingID: C:phenotypes->MeSH
mondoID: C:phenotypes->MONDO
nationalDrugFileReferenceTerminologyCode: C:phenotypes->NDFRT
pharmGKBID: C:phenotypes->pharmGKBID
snomedCT: C:phenotypes->SnoMedCT
synonym: C:phenotypes->synonyms
umlsConceptUniqueID: C:phenotypes->UMLS
url: C:phenotypes->URL
13 changes: 13 additions & 0 deletions scripts/biomedical/PharmGKB/tMCFs/phenotypes_mesh_qualifier.tmcf
Original file line number Diff line number Diff line change
@@ -0,0 +1,13 @@
Node: E:phenotypes_mesh_qualifier->E1
typeOf: dcs:MeSHDescriptor
dcid: C:phenotypes_mesh_qualifier->dcid_mesh
name: C:phenotypes_mesh_qualifier->Name
medicalDictionaryForRegulatoryActivitiesId: C:phenotypes_mesh_qualifier->MedDRA
medicalSubjectHeadingID: C:phenotypes_mesh_qualifier->MeSH
mondoID: C:phenotypes_mesh_qualifier->MONDO
nationalDrugFileReferenceTerminologyCode: C:phenotypes_mesh_qualifier->NDFRT
pharmGKBID: C:phenotypes_mesh_qualifier->pharmGKBID
snomedCT: C:phenotypes_mesh_qualifier->SnoMedCT
synonym: C:phenotypes_mesh_qualifier->synonyms
umlsConceptUniqueID: C:phenotypes_mesh_qualifier->UMLS
url: C:phenotypes_mesh_qualifier->URL
Original file line number Diff line number Diff line change
@@ -0,0 +1,13 @@
Node: E:phenotypes_mesh_supplementary_concept_record->E1
typeOf: dcs:MeSHDescriptor
dcid: C:phenotypes_mesh_supplementary_concept_record->dcid_mesh
name: C:phenotypes_mesh_supplementary_concept_record->Name
medicalDictionaryForRegulatoryActivitiesId: C:phenotypes_mesh_supplementary_concept_record->MedDRA
medicalSubjectHeadingID: C:phenotypes_mesh_supplementary_concept_record->MeSH
mondoID: C:phenotypes_mesh_supplementary_concept_record->MONDO
nationalDrugFileReferenceTerminologyCode: C:phenotypes_mesh_supplementary_concept_record->NDFRT
pharmGKBID: C:phenotypes_mesh_supplementary_concept_record->pharmGKBID
snomedCT: C:phenotypes_mesh_supplementary_concept_record->SnoMedCT
synonym: C:phenotypes_mesh_supplementary_concept_record->synonyms
umlsConceptUniqueID: C:phenotypes_mesh_supplementary_concept_record->UMLS
url: C:phenotypes_mesh_supplementary_concept_record->URL
19 changes: 16 additions & 3 deletions scripts/biomedical/PharmGKB/tMCFs/variants.tmcf
Original file line number Diff line number Diff line change
@@ -1,6 +1,19 @@
Node: E:variants->E1
typeOf: dcs:Gene
dcid: C:variants->dcid_gene
name: C:variants->geneSymbols
pharmGKBID: C:variants->geneID

Node: E:variants->E2
typeOf: dcs:GeneticVariant
dcid: C:variants->dcid
name: C:variants->Variant Name
pharmGKBID: C:variants->Variant ID
rsID: C:variants->Variant ID
name: C:variants->rsID
clinicalAnnotationCount: C:variants->clinicalAnnotationCount
clinicalAnnotationCountLevel1_2: C:variants->clinicalAnnotationCountLevel1_2
clinicalGuidelineAnnotationCount: C:variants->guidelineAnnotationCount
drugLabelAnnotationCount: C:variants->labelAnnotationCount
geneSymbol: E:variants->E1
geneticVariantAnnotationCount: C:variants->variantAnnotationCount
pharmGKBID: C:variants->pharmGKBID
rsID: C:variants->rsID
synonym: C:variants->Synonyms

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