PharmGKB Data Import #1056
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PharmGKB Data Import #1056
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Add README.md file that explains the import including introducing the datasets, description of the import, file artifacts, and import procedure
Add initial draft of README.md from Suhana
Add tmcf and scripts files that support import of primary and relationships data from PharmGKB
Add manual mapping file between diseases PharmGKB Ids and MeSH Descriptor Ids, which are not retrieved via name matching to existing MeSH Descriptor nodes using the datacommons API
Add the mapping files between pharmgkb ids of chemicals and drugs to dcids representing existing corresponding nodes in data commons. These files are generated as output by the `format_chemicals.py` and the `format_drugs.py` scripts respectively.
Update table of contents including adding new sections, update the import procedure, script files and links, and the Notes and Caveat subsection
Fill in Dataset Documentation and Releavant Links subsection
Fix superscripting
Add About the Dataset, Download Data, and Dataset Overview subsections
Fill in the Artifacts subsection
Fill in schema overview subsection
update paths to tmcf files and the new schema subsection
update dcid Generation subsection for phenotypes
update New Schema subsection
update information regarding tests
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Jul 17, 2024
…ng and formatting of the PharmGKB CSV+tMCF pairs. It also breaks out the phenotypes to distinguish that one is a MeSHQualifier and seven are MeSHSupplementaryConceptRecords, unlike the rest of the phenotypes which are MeSHDescriptors. Therefore these were separated into 3 CSV+tMCF pairs. In particular, the links to the enums and between entity types were fixed. This was done by initializing all nodes referenced and then pointing to them within the tMCF. Because of this any existence missing errors in the json reports can be ignored. The changes to the scripts, tMCF files, and documentation (README.md) for this import are part of GitHub PR 1056 datacommonsorg/data#1056 Schema Changes: - Add CPICLevelEnum, DosageGuidelineSourceCpicNoRecommendation, DrugTypeEnum, PGxLevelEnum, PharmacogeneticAssociationEnum. - Add properties for clinicalAnnotationCount, clinicalAnnotationCountLevel1_2, clinicalGuidelineAnnotationCount, dosageGuideline, drugHasPrescribingInfo, drugLabelAnnotationCount, drugType, fdaTopPharmacogeneticLevel, geneticVariantAnnotationCount, hasCpicDosingGuideline, hasGenomicCoordinates, hasGeneticVariantAnnotation, hasPrescribingInfo, medicalDictionaryForRegulatoryActivitiesId, metabolicPathwayCount, pharmageneticAssociation, topClinicalAnnotationLevel, topCpicLevel, topPharmacogeneticLevel, veryImportantPharmacogeneCount. - Remove properties for fdaTopPGxLevel, mintID, nationalClinicalTrialNumber, nationalDrugCode, nationalDrugFileReferenceTerminologyCode, neuroMabID, patentID,pharmGkbClinicalAnnotationCount,pharmGkbPathwayCount, pkgbTags. PiperOrigin-RevId: 653311391
copybara-service bot
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Jul 17, 2024
…ng and formatting of the PharmGKB CSV+tMCF pairs. It also breaks out the phenotypes to distinguish that one is a MeSHQualifier and seven are MeSHSupplementaryConceptRecords, unlike the rest of the phenotypes which are MeSHDescriptors. Therefore these were separated into 3 CSV+tMCF pairs. In particular, the links to the enums and between entity types were fixed. This was done by initializing all nodes referenced and then pointing to them within the tMCF. Because of this any existence missing errors in the json reports can be ignored. The changes to the scripts, tMCF files, and documentation (README.md) for this import are part of GitHub PR 1056 datacommonsorg/data#1056 Schema Changes: - Add CPICLevelEnum, DosageGuidelineSourceCpicNoRecommendation, DrugTypeEnum, PGxLevelEnum, PharmacogeneticAssociationEnum. - Add properties for clinicalAnnotationCount, clinicalAnnotationCountLevel1_2, clinicalGuidelineAnnotationCount, dosageGuideline, drugHasPrescribingInfo, drugLabelAnnotationCount, drugType, fdaTopPharmacogeneticLevel, geneticVariantAnnotationCount, hasCpicDosingGuideline, hasGenomicCoordinates, hasGeneticVariantAnnotation, hasPrescribingInfo, medicalDictionaryForRegulatoryActivitiesId, metabolicPathwayCount, pharmageneticAssociation, topClinicalAnnotationLevel, topCpicLevel, topPharmacogeneticLevel, veryImportantPharmacogeneCount. - Remove properties for fdaTopPGxLevel, mintID, nationalClinicalTrialNumber, nationalDrugCode, nationalDrugFileReferenceTerminologyCode, neuroMabID, patentID,pharmGkbClinicalAnnotationCount,pharmGkbPathwayCount, pkgbTags. PiperOrigin-RevId: 653311391
copybara-service bot
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Jul 17, 2024
…ng and formatting of the PharmGKB CSV+tMCF pairs. It also breaks out the phenotypes to distinguish that one is a MeSHQualifier and seven are MeSHSupplementaryConceptRecords, unlike the rest of the phenotypes which are MeSHDescriptors. Therefore these were separated into 3 CSV+tMCF pairs. In particular, the links to the enums and between entity types were fixed. This was done by initializing all nodes referenced and then pointing to them within the tMCF. Because of this any existence missing errors in the json reports can be ignored. The changes to the scripts, tMCF files, and documentation (README.md) for this import are part of GitHub PR 1056 datacommonsorg/data#1056 Schema Changes: - Add CPICLevelEnum, DosageGuidelineSourceCpicNoRecommendation, DrugTypeEnum, PGxLevelEnum, PharmacogeneticAssociationEnum. - Add properties for clinicalAnnotationCount, clinicalAnnotationCountLevel1_2, clinicalGuidelineAnnotationCount, dosageGuideline, drugHasPrescribingInfo, drugLabelAnnotationCount, drugType, fdaTopPharmacogeneticLevel, geneticVariantAnnotationCount, hasCpicDosingGuideline, hasGenomicCoordinates, hasGeneticVariantAnnotation, hasPrescribingInfo, medicalDictionaryForRegulatoryActivitiesId, metabolicPathwayCount, pharmageneticAssociation, topClinicalAnnotationLevel, topCpicLevel, topPharmacogeneticLevel, veryImportantPharmacogeneCount. - Remove properties for fdaTopPGxLevel, mintID, nationalClinicalTrialNumber, nationalDrugCode, nationalDrugFileReferenceTerminologyCode, neuroMabID, patentID,pharmGkbClinicalAnnotationCount,pharmGkbPathwayCount, pkgbTags. PiperOrigin-RevId: 653311391
copybara-service bot
pushed a commit
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Jul 17, 2024
…ng and formatting of the PharmGKB CSV+tMCF pairs. It also breaks out the phenotypes to distinguish that one is a MeSHQualifier and seven are MeSHSupplementaryConceptRecords, unlike the rest of the phenotypes which are MeSHDescriptors. Therefore these were separated into 3 CSV+tMCF pairs. In particular, the links to the enums and between entity types were fixed. This was done by initializing all nodes referenced and then pointing to them within the tMCF. Because of this any existence missing errors in the json reports can be ignored. The changes to the scripts, tMCF files, and documentation (README.md) for this import are part of GitHub PR 1056 datacommonsorg/data#1056 Schema Changes: - Add CPICLevelEnum, DosageGuidelineSourceCpicNoRecommendation, DrugTypeEnum, PGxLevelEnum, PharmacogeneticAssociationEnum. - Add properties for clinicalAnnotationCount, clinicalAnnotationCountLevel1_2, clinicalGuidelineAnnotationCount, dosageGuideline, drugHasPrescribingInfo, drugLabelAnnotationCount, drugType, fdaTopPharmacogeneticLevel, geneticVariantAnnotationCount, hasCpicDosingGuideline, hasGenomicCoordinates, hasGeneticVariantAnnotation, hasPrescribingInfo, medicalDictionaryForRegulatoryActivitiesId, metabolicPathwayCount, pharmageneticAssociation, topClinicalAnnotationLevel, topCpicLevel, topPharmacogeneticLevel, veryImportantPharmacogeneCount. - Remove properties for fdaTopPGxLevel, mintID, nationalClinicalTrialNumber, nationalDrugCode, nationalDrugFileReferenceTerminologyCode, neuroMabID, patentID,pharmGkbClinicalAnnotationCount,pharmGkbPathwayCount, pkgbTags. PiperOrigin-RevId: 653311391
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Jul 18, 2024
…ng and formatting of the PharmGKB CSV+tMCF pairs. It also breaks out the phenotypes to distinguish that one is a MeSHQualifier and seven are MeSHSupplementaryConceptRecords, unlike the rest of the phenotypes which are MeSHDescriptors. Therefore these were separated into 3 CSV+tMCF pairs. In particular, the links to the enums and between entity types were fixed. This was done by initializing all nodes referenced and then pointing to them within the tMCF. Because of this any existence missing errors in the json reports can be ignored. The changes to the scripts, tMCF files, and documentation (README.md) for this import are part of GitHub PR 1056 datacommonsorg/data#1056 Schema Changes: - Add CPICLevelEnum, DosageGuidelineSourceCpicNoRecommendation, DrugTypeEnum, PGxLevelEnum, PharmacogeneticAssociationEnum. - Add properties for clinicalAnnotationCount, clinicalAnnotationCountLevel1_2, clinicalGuidelineAnnotationCount, dosageGuideline, drugHasPrescribingInfo, drugLabelAnnotationCount, drugType, fdaTopPharmacogeneticLevel, geneticVariantAnnotationCount, hasCpicDosingGuideline, hasGenomicCoordinates, hasGeneticVariantAnnotation, hasPrescribingInfo, medicalDictionaryForRegulatoryActivitiesId, metabolicPathwayCount, pharmageneticAssociation, topClinicalAnnotationLevel, topCpicLevel, topPharmacogeneticLevel, veryImportantPharmacogeneCount. - Remove properties for fdaTopPGxLevel, mintID, nationalClinicalTrialNumber, nationalDrugCode, nationalDrugFileReferenceTerminologyCode, neuroMabID, patentID,pharmGkbClinicalAnnotationCount,pharmGkbPathwayCount, pkgbTags. PiperOrigin-RevId: 653311391
copybara-service bot
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Jul 23, 2024
…ng and formatting of the PharmGKB CSV+tMCF pairs. It also breaks out the phenotypes to distinguish that one is a MeSHQualifier and seven are MeSHSupplementaryConceptRecords, unlike the rest of the phenotypes which are MeSHDescriptors. Therefore these were separated into 3 CSV+tMCF pairs. In particular, the links to the enums and between entity types were fixed. This was done by initializing all nodes referenced and then pointing to them within the tMCF. Because of this any existence missing errors in the json reports can be ignored. The changes to the scripts, tMCF files, and documentation (README.md) for this import are part of GitHub PR 1056 datacommonsorg/data#1056 Schema Changes: - Add CPICLevelEnum, DosageGuidelineSourceCpicNoRecommendation, DrugTypeEnum, PGxLevelEnum, PharmacogeneticAssociationEnum. - Add properties for clinicalAnnotationCount, clinicalAnnotationCountLevel1_2, clinicalGuidelineAnnotationCount, dosageGuideline, drugHasPrescribingInfo, drugLabelAnnotationCount, drugType, fdaTopPharmacogeneticLevel, geneticVariantAnnotationCount, hasCpicDosingGuideline, hasGenomicCoordinates, hasGeneticVariantAnnotation, hasPrescribingInfo, medicalDictionaryForRegulatoryActivitiesId, metabolicPathwayCount, pharmageneticAssociation, topClinicalAnnotationLevel, topCpicLevel, topPharmacogeneticLevel, veryImportantPharmacogeneCount. - Remove properties for fdaTopPGxLevel, mintID, nationalClinicalTrialNumber, nationalDrugCode, nationalDrugFileReferenceTerminologyCode, neuroMabID, patentID,pharmGkbClinicalAnnotationCount,pharmGkbPathwayCount, pkgbTags. PiperOrigin-RevId: 653311391
copybara-service bot
pushed a commit
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Jul 23, 2024
…ng and formatting of the PharmGKB CSV+tMCF pairs. It also breaks out the phenotypes to distinguish that one is a MeSHQualifier and seven are MeSHSupplementaryConceptRecords, unlike the rest of the phenotypes which are MeSHDescriptors. Therefore these were separated into 3 CSV+tMCF pairs. In particular, the links to the enums and between entity types were fixed. This was done by initializing all nodes referenced and then pointing to them within the tMCF. Because of this any existence missing errors in the json reports can be ignored. The changes to the scripts, tMCF files, and documentation (README.md) for this import are part of GitHub PR 1056 datacommonsorg/data#1056 Schema Changes: - Add CPICLevelEnum, DosageGuidelineSourceCpicNoRecommendation, DrugTypeEnum, PGxLevelEnum, PharmacogeneticAssociationEnum. - Add properties for clinicalAnnotationCount, clinicalAnnotationCountLevel1_2, clinicalGuidelineAnnotationCount, dosageGuideline, drugHasPrescribingInfo, drugLabelAnnotationCount, drugType, fdaTopPharmacogeneticLevel, geneticVariantAnnotationCount, hasCpicDosingGuideline, hasGenomicCoordinates, hasGeneticVariantAnnotation, hasPrescribingInfo, medicalDictionaryForRegulatoryActivitiesId, metabolicPathwayCount, pharmageneticAssociation, topClinicalAnnotationLevel, topCpicLevel, topPharmacogeneticLevel, veryImportantPharmacogeneCount. - Remove properties for fdaTopPGxLevel, mintID, nationalClinicalTrialNumber, nationalDrugCode, nationalDrugFileReferenceTerminologyCode, neuroMabID, patentID,pharmGkbClinicalAnnotationCount,pharmGkbPathwayCount, pkgbTags. PiperOrigin-RevId: 655002332
Add information about dcid illegal character @ being replaced with _Cluster when generating Gene dcids.
spiekos
requested review from
dwnoble and
clincoln8
and removed request for
pradh
Update gene_var.tmcf to ssign Entity2 as Variant and Entity1 as Gene in the output csv file.
Fix references for entity1 vs entity2 in output file so that they correctly map to the GeneticVariant and Gene entities
Fix hierarchical ontology for classes used in import
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This documents the PharmGKB data import including introducing the data, the import process, new schema, scripts, tmcfs, and import process.