4b-dev-gslabel-uts.json

[
  {
    "qid": "55046d5ff8aee20f27000007",
    "question": "List signaling molecules (ligands) that interact with the receptor EGFR?",
    "answer-types": {
      "amphiregulin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "betacellulin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "transforming growth factor-α": [],
      "epiregulin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "epigen": [
        "umls:aapp"
      ],
      "heparin-binding epidermal growth factor": [
        "umls:gngm"
      ],
      "epidermal growth factor": [
        "umls:horm",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:horm": 1,
      "umls:gngm": 1,
      "umls:bacs": 3,
      "umls:phsu": 1,
      "umls:aapp": 5
    }
  },
  {
    "qid": "52f8b2902059c6d71c000053",
    "question": "Which thyroid hormone transporter is implicated in thyroid hormone resistance syndrome?",
    "answer-types": {
      "TH monocarboxylate transporter 8 (MCT8) mutation is implicated in the TH resistance syndrome": [],
      "TH monocarboxylate transporter 8": [],
      "MCT8": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "553fa78b1d53b76422000007",
    "question": "Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer?",
    "answer-types": {
      "miR-200c": [
        "umls:gngm"
      ],
      "miR-26a": [
        "umls:gngm"
      ],
      "miR-200b": [
        "umls:gngm"
      ],
      "miR-200a": [
        "umls:gngm"
      ],
      "let-7a": [
        "umls:gngm"
      ],
      "let-7b": [
        "umls:gngm"
      ],
      "miR-148a": [
        "umls:gngm"
      ],
      "miR-510": [
        "umls:gngm"
      ],
      "miR-203": [
        "umls:gngm"
      ],
      "let-7i": [
        "umls:gngm"
      ],
      "miR-132": [
        "umls:gngm"
      ],
      "miR-100": [
        "umls:gngm"
      ],
      "miR-145": [
        "umls:gngm"
      ],
      "miR-182": [
        "umls:gngm"
      ],
      "miR-21": [
        "umls:gngm"
      ],
      "miR-141": [
        "umls:gngm"
      ],
      "miR-152": [
        "umls:gngm"
      ],
      "miR-93": [
        "umls:gngm"
      ],
      "miR-92": [
        "umls:gngm"
      ],
      "miR-509-5p": []
    },
    "type-counts": {
      "umls:gngm": 19
    }
  },
  {
    "qid": "5149199dd24251bc05000040",
    "question": "Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis?",
    "answer-types": {
      "neostigmine": [
        "umls:orch",
        "umls:phsu"
      ],
      "pyridostigmine": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "5709e4b2cf1c32585100001c",
    "question": "List the human genes encoding for the dishevelled proteins?",
    "answer-types": {
      "DVL-3": [
        "umls:bacs",
        "umls:aapp"
      ],
      "DVL-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "DVL-2": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 3,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56bc751eac7ad10019000013",
    "question": "Name synonym of Acrokeratosis paraneoplastica.",
    "answer-types": {
      "Bazex syndrome": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "54d4e03a3706e89528000001",
    "question": "Which are the classes of anti-arrhythmic drugs according to Vaughan-Williams classification?",
    "answer-types": {
      "Class III: potassium channel blockers": [],
      "Class I: sodium channel blockers": [],
      "ClassII: beta blockers": [],
      "Class IV: calcium channel blockers": []
    },
    "type-counts": {}
  },
  {
    "qid": "55072c803b8a5dc045000001",
    "question": "Which are the different isoforms of the mammalian Notch receptor?",
    "answer-types": {
      "Notch-2": [
        "umls:gngm"
      ],
      "Notch-1": [
        "umls:gngm"
      ],
      "Notch-4": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Notch-3": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 3,
      "umls:aapp": 1
    }
  },
  {
    "qid": "53061af558348c0f52000002",
    "question": "Which are the major characteristics of cellular senescence?",
    "answer-types": {
      "development of aberrant gene expression with proinflammatory behavior": [],
      "altered morphology": [],
      "telomere shortening": [
        "umls:comd"
      ],
      "arrested cell-cycle progression": [
        "umls:celf"
      ]
    },
    "type-counts": {
      "umls:celf": 1,
      "umls:comd": 1
    }
  },
  {
    "qid": "56c1f01def6e394741000045",
    "question": "Orteronel was developed for treatment of which cancer?",
    "answer-types": {
      "castration-resistant prostate cancer": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "54d643023706e89528000007",
    "question": "Which is the protein that is encoded by the gene GLT8D1?",
    "answer-types": {
      "glycosyltransferase 8 domain containing 1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "53137541e3eabad021000010",
    "question": "Which are the Yamanaka factors?",
    "answer-types": {
      "OCT4": [
        "umls:gngm"
      ],
      "SOX2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "c-MYC": [
        "umls:gngm"
      ],
      "MYC": [
        "umls:bacs",
        "umls:aapp"
      ],
      "KLF4": [
        "umls:gngm"
      ],
      "Oct3/4": [],
      "Pou5f1": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 3,
      "umls:gngm": 3,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56af9f130a360a5e45000015",
    "question": "Where is the protein Pannexin1 located?",
    "answer-types": {
      "plasma membrane": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "5718bbb37de986d80d00000b",
    "question": "Which currently known mitochondrial diseases have been attributed to POLG mutations?",
    "answer-types": {
      "Ataxia Neuropathy Spectrum": [
        "umls:dsyn"
      ],
      "arPEO": [],
      "MCHS": [
        "umls:prog"
      ],
      "ANS": [
        "umls:bdsy"
      ],
      "Ataxia Neuropathy Spectrum (ANS) disorders": [
        "umls:dsyn"
      ],
      "Alpers syndrome": [
        "umls:dsyn"
      ],
      "Myoclonus Epilepsy Myopathy Sensory Ataxia": [],
      "childhood Myocerebrohepatopathy Spectrum disorders": [
        "umls:dsyn"
      ],
      "Myoclonus Epilepsy Myopathy Sensory Ataxia (MEMSA)": [],
      "childhood Myocerebrohepatopathy Spectrum disorders (MCHS)": [],
      "autosomal recessive Progressive External Ophthalmoplegia": [
        "umls:dsyn"
      ],
      "autosomal dominant Progressive External Ophthalmoplegia (adPEO)": [
        "umls:dsyn"
      ],
      "adPEO": [],
      "autosomal recessive Progressive External Ophthalmoplegia (arPEO)": [
        "umls:dsyn"
      ],
      "autosomal dominant Progressive External Ophthalmoplegia": [
        "umls:dsyn"
      ],
      "MEMSA": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:bdsy": 1,
      "umls:dsyn": 9,
      "umls:prog": 1
    }
  },
  {
    "qid": "52bf1b0a03868f1b06000009",
    "question": "What is the mode of inheritance of Wilson\u0027s disease?",
    "answer-types": {
      "autosomal recessive": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "52bf19c503868f1b06000001",
    "question": "What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?",
    "answer-types": {
      "autosomal dominant": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "54f9d3eedd3fc62544000004",
    "question": "Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex?",
    "answer-types": {
      "Calsequestrin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "CSQ": [
        "umls:inpr"
      ],
      "TRN": [
        "umls:celc"
      ],
      "JUN": [
        "umls:gngm"
      ],
      "CASQ": [
        "umls:gngm"
      ],
      "JCN": [
        "umls:bact"
      ],
      "Ryanodine receptor": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "TrD": [
        "umls:dsyn"
      ],
      "Junctin": [
        "umls:gngm"
      ],
      "RyR": [
        "umls:gngm"
      ],
      "Triadin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "JnC": [
        "umls:cgab"
      ]
    },
    "type-counts": {
      "umls:celc": 1,
      "umls:cgab": 1,
      "umls:inpr": 1,
      "umls:dsyn": 1,
      "umls:rcpt": 1,
      "umls:gngm": 4,
      "umls:bacs": 2,
      "umls:bact": 1,
      "umls:aapp": 3
    }
  },
  {
    "qid": "5505edac8e1671127b000005",
    "question": "What kind of chromatography is HILIC?",
    "answer-types": {
      "Hydrophilic Interaction Chromatography": []
    },
    "type-counts": {}
  },
  {
    "qid": "56e2cec751531f7e33000015",
    "question": "What is the structural fold of bromodomain proteins?",
    "answer-types": {
      "All-alpha-helical fold": []
    },
    "type-counts": {}
  },
  {
    "qid": "515deafd298dcd4e51000025",
    "question": "List the endoscopic diagnoses that have been reported in children with autism",
    "answer-types": {
      "Ileo-colonic lymphoid nodular hyperplasia (LNH)": [],
      "inflammation of the small bowel and colorectum": [],
      "chronic duodenitis": [
        "umls:dsyn"
      ],
      "LNH": [
        "umls:neop"
      ],
      "Achalasia": [
        "umls:dsyn"
      ],
      "Ileo-colonic lymphoid nodular hyperplasia": [],
      "Reflux esophagitis": [
        "umls:dsyn"
      ],
      "chronic gastritis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:neop": 1,
      "umls:dsyn": 4
    }
  },
  {
    "qid": "5518e7da622b194345000004",
    "question": "Which MAP kinase phosphorylates the transcription factor c-jun?",
    "answer-types": {
      "c-Jun NH2-terminal kinase": [
        "umls:imft",
        "umls:aapp"
      ],
      "JNK": [
        "umls:moft"
      ]
    },
    "type-counts": {
      "umls:moft": 1,
      "umls:imft": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "530a5117970c65fa6b000007",
    "question": "What is the meaning of the acronym \"TAILS\" used in protein N-terminomics?",
    "answer-types": {
      "TAILS: Terminal Amine Isotopic Labeling of Substrates": []
    },
    "type-counts": {}
  },
  {
    "qid": "52bf202003868f1b06000018",
    "question": "What are the main indications of lacosamide?",
    "answer-types": {
      "epilepsy": [
        "umls:dsyn"
      ],
      "refractory epilepsy": [
        "umls:dsyn"
      ],
      "analgesic": [
        "umls:hops",
        "umls:orch",
        "umls:phsu"
      ],
      "CNS disorders": [
        "umls:dsyn"
      ],
      "refractory partial-onset seizures": []
    },
    "type-counts": {
      "umls:hops": 1,
      "umls:orch": 1,
      "umls:dsyn": 3,
      "umls:phsu": 1
    }
  },
  {
    "qid": "552fac4fbc4f83e828000006",
    "question": "Which fusion protein is involved in the development of Ewing sarcoma?",
    "answer-types": {
      "EWS/FLI1": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:aapp": 1
    }
  },
  {
    "qid": "56be0da3ef6e394741000007",
    "question": "List Hemolytic Uremic Syndrome Triad.",
    "answer-types": {
      "anaemia": [
        "umls:dsyn"
      ],
      "thrombocytopenia": [
        "umls:dsyn"
      ],
      "renal failure": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 3
    }
  },
  {
    "qid": "515a7ffdd24251bc050000a5",
    "question": "What are the effects of depleting protein km23-1 (DYNLRB1) in a cell?",
    "answer-types": {
      "inhibition of cell migration of human colon carcinoma cells (HCCCs) in wound-healing assays": [],
      "decreased key TGFbeta responses": [],
      "phosphorylation of c-Jun": [],
      "inhibition of TGFβ-mediated activation of ERK and JNK": [],
      "decreased RhoA activation": [],
      "transactivation of the c-Jun promoter": [],
      "inhibition of cell migration of human colon carcinoma cells": [],
      "HCCCs": []
    },
    "type-counts": {}
  },
  {
    "qid": "54cf7051f693c3b16b000013",
    "question": "Treatment of which disease was investigated in the MR CLEAN study?",
    "answer-types": {
      "acute ischemic stroke": [
        "umls:topp"
      ]
    },
    "type-counts": {
      "umls:topp": 1
    }
  },
  {
    "qid": "56a92be0a17756b72f000009",
    "question": "Which factors activate zygotic gene expression during the maternal-to-zygotic transition in zebrafish?",
    "answer-types": {
      "Nanog": [
        "umls:gngm"
      ],
      "SoxB1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Pou5f1": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 2,
      "umls:gngm": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "54e0d1491388e8454a000014",
    "question": "Which enzyme is targeted by Evolocumab?",
    "answer-types": {
      "proprotein convertase subtilisin/kexin type 9": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "51404dd723fec90375000002",
    "question": "What is the methyl donor of DNA (cytosine-5)-methyltransferases?",
    "answer-types": {
      "S-adenosyl-L-methionine": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56d0451c3975bb303a00000e",
    "question": "Which signaling pathway does sonidegib inhibit?",
    "answer-types": {
      "Hedghog signalling pathway": []
    },
    "type-counts": {}
  },
  {
    "qid": "54ede8c594afd61504000009",
    "question": "In which phase of the cell cycle arrest is impaired in Fanconi anemia?",
    "answer-types": {
      "In Fanconi anemia cells, the S-phase checkpoint is inefficient.": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c3327c50c68dd41600000c",
    "question": "Which DNA sequences are more prone for the formation of R-loops?",
    "answer-types": {
      "(CTG)n, (CAG)n, (CGG)n, (CCG)n and (GAA)n": [
        "umls:gngm"
      ],
      "G-rich elements": [],
      "CpG islands": [
        "umls:nnon",
        "umls:bacs"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:bacs": 1,
      "umls:gngm": 1
    }
  },
  {
    "qid": "551c23bc6b348bb82c00000b",
    "question": "Mutation of which gene is implicated in the familial isolated pituitary adenoma?",
    "answer-types": {
      "aryl hydrocarbon receptor interacting protein": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "5314a7a4dae131f847000003",
    "question": "which mutations of troponin C gene have been found to cause hypertrophic cardiomyopathy?",
    "answer-types": {
      "A23Q": [],
      "D145E": [],
      "c.363dupG": [],
      "E134D": [],
      "C84Y": [],
      "A31S": [],
      "L29Q": [],
      "A8V": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c6dd275795f9a73e000008",
    "question": "Which post-translational histone modifications are characteristic of constitutive heterochromatin?",
    "answer-types": {
      "H4K20me3": [
        "umls:moft"
      ],
      "H3K9me2": [],
      "H3K9me3": [],
      "H3K79me3": [],
      "H3S10p": [],
      "H3K27me2": [
        "umls:aapp"
      ],
      "H3K27me1": [],
      "H3K36me3": [],
      "H3K27me3": [
        "umls:moft"
      ]
    },
    "type-counts": {
      "umls:moft": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56c1f02cef6e39474100004c",
    "question": "GV1001 vaccine targets which enzyme?",
    "answer-types": {
      "human telomerase reverse transcriptase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "550af222c2af5d5b7000000b",
    "question": "Which is the E3 ubiquitin ligase which ubiquitinates IkB leading to its proteasomal degradation?",
    "answer-types": {
      "SCF beta-transducin repeat-containing protein (beta-TrCP)": [],
      "SCF(β-TrCP)": [],
      "SCF beta-transducin repeat-containing protein": [],
      "beta-Trcp": [
        "umls:bacs",
        "umls:aapp"
      ],
      "beta-TrCP": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "532819afd6d3ac6a3400000f",
    "question": "Is there a crystal structure of Greek Goat Encephalitis?",
    "answer-types": {
      "No crustal structure of Greek Goat Encephalitis found": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c1f03bef6e394741000053",
    "question": "Mutation of which gene is implicated in the Brain-lung-thyroid syndrome?",
    "answer-types": {
      "thyroid transcription factor 1": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "532498959b2d7acc7e000017",
    "question": "Which enzyme is targeted by the drug Imetelstat?",
    "answer-types": {
      "Human Telomerase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56c1f005ef6e39474100003a",
    "question": "Which interleukins are inhibited by Dupilumab?",
    "answer-types": {
      "interleukin-4": [
        "umls:imft",
        "umls:aapp"
      ],
      "interleukin-13": [
        "umls:imft",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "513ce3c8bee46bd34c000008",
    "question": "Which human genes are more commonly related to craniosynostosis?",
    "answer-types": {
      "RECQL4": [
        "umls:gngm"
      ],
      "NELL1": [
        "umls:gngm"
      ],
      "MSX2": [
        "umls:gngm"
      ],
      "GNAS": [
        "umls:gngm"
      ],
      "SOX6": [
        "umls:gngm"
      ],
      "FGFR3": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "FGFR2": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "RUNX2": [
        "umls:gngm"
      ],
      "FGFR1": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "TWIST": [
        "umls:phsf"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:rcpt": 3,
      "umls:phsf": 1,
      "umls:gngm": 6,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56d06e043975bb303a000011",
    "question": "In which breast cancer patients can palbociclib be used?",
    "answer-types": {
      "hormone receptor-positive, human epidermal growth factor receptor 2-negative": []
    },
    "type-counts": {}
  },
  {
    "qid": "571e1e11bb137a4b0c000004",
    "question": "List side effects of SGLT2 inhibitors?",
    "answer-types": {
      "urinary tract infections": [
        "umls:dsyn"
      ],
      "genital infections": [
        "umls:dsyn"
      ],
      "low blood pressure": [
        "umls:fndg"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "5509f433c2af5d5b70000008",
    "question": "What is the method FASP used for?",
    "answer-types": {
      "proteomic sample preparation": []
    },
    "type-counts": {}
  },
  {
    "qid": "533f9df0c45e133714000016",
    "question": "What is being measured with an accelerometer in back pain patients",
    "answer-types": {
      "Standing time": [
        "umls:fndg"
      ],
      "PA": [
        "umls:hlca"
      ],
      "Constant Strain Postures": [],
      "CSP": [
        "umls:neop"
      ],
      "ST": [
        "umls:geoa"
      ],
      "Lying time": [
        "umls:clna"
      ],
      "Physical activity": [
        "umls:dora"
      ],
      "constant postures": [],
      "LT": [
        "umls:geoa"
      ],
      "PAL": [
        "umls:moft"
      ]
    },
    "type-counts": {
      "umls:dora": 1,
      "umls:fndg": 1,
      "umls:moft": 1,
      "umls:clna": 1,
      "umls:neop": 1,
      "umls:hlca": 1,
      "umls:geoa": 2
    }
  },
  {
    "qid": "56a3a386496b62f23f000007",
    "question": "List the releases of JASPAR database",
    "answer-types": {
      "JASPAR 2014": [],
      "JASPAR": [],
      "JASPAR 2010": [],
      "JASPAR phyloFACTS": [],
      "JASPAR FAM": [],
      "JASPAR 2008 update": [],
      "JASPAR CORE": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c1f038ef6e394741000051",
    "question": "List symptoms of the IFAP syndrome.",
    "answer-types": {
      "follicular ichthyosis": [
        "umls:cgab"
      ],
      "atrichia": [
        "umls:dsyn"
      ],
      "photophobia": [
        "umls:sosy"
      ]
    },
    "type-counts": {
      "umls:sosy": 1,
      "umls:cgab": 1,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "531a34d5b166e2b806000036",
    "question": "Which gene is required for the efficient function of clopidogrel?",
    "answer-types": {
      "cytochrome P450, CYPC19": []
    },
    "type-counts": {}
  },
  {
    "qid": "56cdf40d5795f9a73e00003d",
    "question": "Which transcription factor is considered as a master regulator of lysosomal genes?",
    "answer-types": {
      "Transcription factor EB": [
        "umls:gngm"
      ],
      "Transcription factor EB (TFEB)": [
        "umls:gngm"
      ],
      "TFEB": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 3
    }
  },
  {
    "qid": "571529efcb4ef8864c000001",
    "question": "Which antibiotics target peptidoglycan biosynthesis?",
    "answer-types": {
      "seromycin": [
        "umls:antb",
        "umls:aapp"
      ],
      "ampicillin": [
        "umls:antb",
        "umls:orch"
      ],
      "cinnamycin": [
        "umls:enzy",
        "umls:aapp"
      ],
      "colchicine": [
        "umls:orch",
        "umls:phsu"
      ],
      "vancomycin": [
        "umls:antb",
        "umls:aapp"
      ],
      "mersacidin": [
        "umls:aapp"
      ],
      "ramoplanin": [
        "umls:antb",
        "umls:aapp"
      ],
      "muraymycin": [
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      ],
      "fosfomycin": [
        "umls:antb",
        "umls:orch"
      ],
      "D-cycloserine": [
        "umls:antb",
        "umls:aapp"
      ],
      "bacitracin": [
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        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:antb": 7,
      "umls:enzy": 1,
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      "umls:phsu": 1,
      "umls:aapp": 7
    }
  },
  {
    "qid": "53358cd2d6d3ac6a3400004e",
    "question": "List two common features of Tay syndrome.",
    "answer-types": {
      "trichothiodystrophy": [
        "umls:dsyn"
      ],
      "ichthyosis": [
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    },
    "type-counts": {
      "umls:dsyn": 2
    }
  },
  {
    "qid": "52b2d405f828ad283c000009",
    "question": "Which cell types are known to be driving Rheumatoid Arthritis?",
    "answer-types": {
      "T-cells": [
        "umls:cell"
      ],
      "Dendritic cells": [
        "umls:cell"
      ],
      "Fibroblast-like synoviocytes (FLS)": [],
      "Fibroblast-like synoviocytes": [],
      "synovial fibroblasts": [],
      "Macrophages": [
        "umls:cell"
      ],
      "FLS": [
        "umls:patf"
      ]
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:cell": 3
    }
  },
  {
    "qid": "553653a5bc4f83e828000007",
    "question": "Which technique is used for detection of EWS/FLI1 fusion transcripts?",
    "answer-types": {
      "RT-PCR": [
        "umls:mbrt"
      ],
      "Reverse transcription - polymerase chain reaction": [
        "umls:mbrt"
      ],
      "Reverse transcription - polymerase chain reaction (RT-PCR)": [
        "umls:mbrt"
      ]
    },
    "type-counts": {
      "umls:mbrt": 3
    }
  },
  {
    "qid": "56c868a95795f9a73e000017",
    "question": "What is the application of the Bimolecular Fluorescence Complementation (BiFC) assay in Drosophila embryos?",
    "answer-types": {
      "The study of protein-protein interactions in a physiologically relevant developing context.": []
    },
    "type-counts": {}
  },
  {
    "qid": "516e5f41298dcd4e5100007f",
    "question": "What is the genetic basis of Rubinstein-Taybi syndrome?",
    "answer-types": {
      "Mutations or/and deletions in the genes of the cAMP-response element binding protein-BP (CREBBP) (50-60% of the cases) and of the homologous gene E1A-binding protein (EP300) at 22q13 (5%).": []
    },
    "type-counts": {}
  },
  {
    "qid": "56ed27012ac5ed145900000b",
    "question": "What is the function of the AIRE gene at the embryonic stage?",
    "answer-types": {
      "stem cell renewal and self-immune tolerance": []
    },
    "type-counts": {}
  },
  {
    "qid": "518cb4b5310faafe08000006",
    "question": "Which drugs are utilized to treat amiodarone-induced thyroitoxicosis?",
    "answer-types": {
      "Corticosteroids": [
        "umls:orch",
        "umls:horm",
        "umls:phsu"
      ],
      "Lithium": [
        "umls:elii",
        "umls:phsu"
      ],
      "Radioiodine": [
        "umls:elii",
        "umls:irda"
      ],
      "Antithyroid drugs": [
        "umls:horm",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:elii": 2,
      "umls:irda": 1,
      "umls:orch": 1,
      "umls:horm": 2,
      "umls:phsu": 3
    }
  },
  {
    "qid": "52f223e02059c6d71c00000e",
    "question": "Which is the genetic defect causing Neurofibromatosis type 1?",
    "answer-types": {
      "Mutation in NF1 gene.": [
        "umls:comd"
      ]
    },
    "type-counts": {
      "umls:comd": 1
    }
  },
  {
    "qid": "5343caffaeec6fbd07000002",
    "question": "Which is the human selenoprotein that contains several Se-Cys residues?",
    "answer-types": {
      "Selenoprotein P": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56a39d60496b62f23f000006",
    "question": "Which package is available for analysing genomic interactions in R/Bioconductor?",
    "answer-types": {
      "r3Cseq": []
    },
    "type-counts": {}
  },
  {
    "qid": "5150b807d24251bc05000072",
    "question": "How many clinical trials for off-label drugs in neonates are cited in the literature.",
    "answer-types": {
      "0": [
        "_QUANTITY"
      ],
      "zero": [
        "_QUANTITY"
      ],
      "none": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 3
    }
  },
  {
    "qid": "56c1d857ef6e394741000033",
    "question": "What enzyme is inhibied by Opicapone?",
    "answer-types": {
      "catechol-O-methyltransferase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "552faa43bc4f83e828000004",
    "question": "Which are the genes thought to be regulated by EWS/FLI?",
    "answer-types": {
      "GSTM4": [
        "umls:gngm"
      ],
      "BCL11B": [
        "umls:gngm"
      ],
      "NRoB1": [
        "umls:gngm"
      ],
      "NKX2.2": [
        "umls:gngm"
      ],
      "p53": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 5
    }
  },
  {
    "qid": "52fe58f82059c6d71c00007a",
    "question": "Do archaeal genomes contain one or multiple origins of replication?",
    "answer-types": {
      "mostly multiple": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "533c3af6c45e13371400000d",
    "question": "Which pathological conditions are caused by mutations in the CYLD gene?",
    "answer-types": {
      "Cylindromatosis": [
        "umls:neop"
      ],
      "BSS": [
        "umls:dsyn"
      ],
      "Brooke-Spiegler syndrome": [
        "umls:dsyn"
      ],
      "MFT": [
        "umls:gngm"
      ],
      "Multiple Familial Trichoepithelioma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 2,
      "umls:dsyn": 2,
      "umls:gngm": 1
    }
  },
  {
    "qid": "56c5fd325795f9a73e000005",
    "question": "Which is the genetic basis of Spinal Muscular Atrophy (SMA)?",
    "answer-types": {
      "The molecular genetic basis of spinal muscular atrophy": [],
      "SMA), an autosomal recessive neuromuscular disorder, is the loss of function of the survival motor neuron gene (SMN1": [],
      "The molecular genetic basis of spinal muscular atrophy (SMA), an autosomal recessive neuromuscular disorder, is the loss of function of the survival motor neuron gene (SMN1)": []
    },
    "type-counts": {}
  },
  {
    "qid": "571f3b320fd6f91b68000007",
    "question": "Which are the common symptoms of Cushing\u0027s syndrome?",
    "answer-types": {
      "hirsutism": [
        "umls:fndg"
      ],
      "acne": [
        "umls:dsyn"
      ],
      "weight gain": [
        "umls:fndg"
      ],
      "striae": [
        "umls:acab"
      ],
      "growth retardation": [
        "umls:patf"
      ],
      "hypertension": [
        "umls:dsyn"
      ],
      "obesity": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:patf": 1,
      "umls:acab": 1,
      "umls:dsyn": 3
    }
  },
  {
    "qid": "5319ac99b166e2b806000034",
    "question": "Which is the third subunit of the TSC1-TSC2 complex upstream of mTORC1?",
    "answer-types": {
      "TBC1D7": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "54f89e1a06d9727f76000001",
    "question": "Which kinase is inhibited by the small molecule KN-93?",
    "answer-types": {
      "CaM kinase II": [
        "umls:enzy",
        "umls:aapp"
      ],
      "The calcium/calmodulin-dependent protein kinase-II": [
        "umls:enzy",
        "umls:aapp"
      ],
      "CAMK2": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1,
      "umls:enzy": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "54d65b6b3706e8952800000c",
    "question": "List genes that have been found mutated in CMT1A (Charcot-Marie-Tooth disease type 1 A).",
    "answer-types": {
      "SH3TC2": [
        "umls:gngm"
      ],
      "MPZ": [
        "umls:gngm"
      ],
      "PMP22": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 3
    }
  },
  {
    "qid": "517a8c918ed59a060a000043",
    "question": "Which viruses are best known to cause myocarditis?",
    "answer-types": {
      "Adenovirus": [
        "umls:virs"
      ],
      "Coxsackie B virus": [
        "umls:virs"
      ],
      "Enterovirus": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:virs": 2,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "571f2b5bbb137a4b0c000010",
    "question": "Which genes have been associated with Cerebral Cavernous Malformation?",
    "answer-types": {
      "CCM3/PDCD10": [],
      "CCM1/KRIT1": [],
      "CCM2/OSM/Malcavernin": []
    },
    "type-counts": {}
  },
  {
    "qid": "571e275dbb137a4b0c000005",
    "question": "What are \u0027vildagliptin\u0027, \u0027sitagliptin\u0027, \u0027saxagliptin\u0027, \u0027alogliptin\u0027, \u0027linagliptin\u0027, and \u0027dutogliptin\u0027?",
    "answer-types": {
      "dipeptidyl peptidase-4 (DPP-4) inhibitors": [
        "umls:enzy",
        "umls:imft",
        "umls:aapp"
      ],
      "dipeptidyl peptidase-4": [
        "umls:enzy",
        "umls:imft",
        "umls:aapp"
      ],
      "DPP-4": [
        "umls:orch"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:orch": 1,
      "umls:imft": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "51739df58ed59a060a00001c",
    "question": "Which is the most important prognosis sub-classification in Chronic Lymphocytic Leukemia?",
    "answer-types": {
      "The mutational status of the IGHV genes.": []
    },
    "type-counts": {}
  },
  {
    "qid": "56e857ae42442bac75000004",
    "question": "What is needed for MMP proteins to be functional?",
    "answer-types": {
      "zinc": [
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        "umls:bacs",
        "umls:phsu"
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    "type-counts": {
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      "umls:bacs": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "5509c52f1180f13250000004",
    "question": "What is hyperosmia",
    "answer-types": {
      "increased olfactory acuity": []
    },
    "type-counts": {}
  },
  {
    "qid": "535d2cf09a4572de6f000004",
    "question": "What is the number of long non coding RNAs in the human genome",
    "answer-types": {
      "between 10,000 and 20,000": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "55475dc2f35db75526000001",
    "question": "Which is the most known bacterium responsible for botulism (sausage-poisoning)?",
    "answer-types": {
      "Clostridium botulinum": [
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      ]
    },
    "type-counts": {
      "umls:bact": 1
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  },
  {
    "qid": "56c073fcef6e394741000020",
    "question": "What is the association of spermidine with α-synuclein neurotoxicity?",
    "answer-types": {
      "Spermidine protects against α-synuclein neurotoxicity": []
    },
    "type-counts": {}
  },
  {
    "qid": "550320cbe9bde6963400002d",
    "question": "List symptoms of 4H leukodystrophy.",
    "answer-types": {
      "hypodontia": [
        "umls:cgab"
      ],
      "hypomyelination": [
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      "hypogonadotropic hypogonadism": [
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    },
    "type-counts": {
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      "umls:cgab": 1,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "511a4d391159fa8212000003",
    "question": "Which are the plant DNA (cytosine-5) methyltransferase families?",
    "answer-types": {
      "CMT": [
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      "MET": [
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        "umls:phsu"
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      "DRM": [
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      "umls:dsyn": 1,
      "umls:gngm": 1,
      "umls:bacs": 1,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52fe52702059c6d71c000078",
    "question": "Where is the histone variant CENPA preferentially localized?",
    "answer-types": {
      "Centromeres": [
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      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "517137c18ed59a060a000001",
    "question": "In which proteins is the chromodomain present?",
    "answer-types": {
      "Corto": [
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      ],
      "MRG15": [
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      "cmt3": [
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      "ScoHET2": [],
      "CDY-like protein": [
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      "MRG1": [
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      "ScoHET1": [],
      "chromodomain Y chromosome": [
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      "HP1 beta": [
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      "HP1 gamma": [
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      "PcG": [
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      "Swi6": [
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      "CDY": [
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      "Polycomb group (PcG) proteins": [
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        "umls:aapp"
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      "cpSRP43": [
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      "CHD1-like": [],
      "Chriz": [],
      "Cbx8": [
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      "CReMM": [
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      "dMi-2": [
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      "Cbx7": [
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      "Cbx6": [
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      "TgMYST-A": [],
      "Cbx4": [
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      "Cbx3": [
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      "Chp1": [
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      "Cbx2": [
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      "ADP/ATP translocase 1": [
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      "TgMYST –B": [],
      "MSL3": [
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      "CHD1L": [
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      "CDYL": [
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      "chromointegrases": [],
      "MPP8": [
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      "PKL": [
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      "HP1 alpha": [
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      "Chromodomain helicase DNA-binding protein": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Polycomb group": [
        "umls:bacs",
        "umls:aapp"
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      "CHD proteins": [],
      "like heterochromatin protein": [
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      "TIP60": [
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      "NlMof": [],
      "transposable elements": [
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      "PICKLE": [
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      "LHP1": [
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      "Kismet": [
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    },
    "type-counts": {
      "umls:nnon": 1,
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      "umls:moft": 1,
      "umls:orch": 2,
      "umls:dsyn": 1,
      "umls:bacs": 9,
      "umls:gngm": 20,
      "umls:food": 1,
      "umls:phsu": 1,
      "umls:aapp": 10,
      "umls:qnco": 1
    }
  },
  {
    "qid": "5339ecf4d6d3ac6a3400005f",
    "question": "Which is the prognostic meaning of delayed enhancement documented in patients hypertrophic cardiomyopathy?",
    "answer-types": {
      "Delayed enhancement by CMR has prognostic value in predicting adverse cardiovascular events among HCM patients.": []
    },
    "type-counts": {}
  },
  {
    "qid": "532083389b2d7acc7e000003",
    "question": "Are there drugs for Tick-borne Encephalitis?",
    "answer-types": {
      "No drug therapy available today": []
    },
    "type-counts": {}
  },
  {
    "qid": "5717d64f29809bbe7a000001",
    "question": "Which is the cellular localization of the protein Opa1?",
    "answer-types": {
      "mitochondrial intermembrane space": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "531d7430267d7dd053000008",
    "question": "Which are the drugs utilized for the burning mouth syndrome?",
    "answer-types": {
      "Capsaicina": [
        "umls:orch",
        "umls:phsu"
      ],
      "Dopaminergig drugs": [],
      "Catuama": [
        "umls:topp"
      ],
      "Alpha-lipoic acid": [
        "umls:vita",
        "umls:orch",
        "umls:phsu"
      ],
      "Clonazepam": [
        "umls:orch",
        "umls:phsu"
      ],
      "Placebo therapy": [
        "umls:topp"
      ]
    },
    "type-counts": {
      "umls:vita": 1,
      "umls:orch": 3,
      "umls:topp": 2,
      "umls:phsu": 3
    }
  },
  {
    "qid": "56c8f4615795f9a73e00001a",
    "question": "Which genome browser database for DNA shape annotations is available?",
    "answer-types": {
      "GBshape": []
    },
    "type-counts": {}
  },
  {
    "qid": "5523f1a62c8b63434a000002",
    "question": "Which mutations of phopspholamban have been found in patients with cardiomyopathy?",
    "answer-types": {
      "R9H": [],
      "R9L": [],
      "PLN R39X": [],
      "Arg(9) to Leu": [
        "umls:aapp"
      ],
      "Arg(9) to Cys": [
        "umls:bacs",
        "umls:aapp"
      ],
      "c.40_42delAGA(p.Arg14del)": [],
      "PLN L39stop": [],
      "Arg(9) to His": [
        "umls:aapp"
      ],
      "PLN R14 del": [],
      "R9C": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 2,
      "umls:aapp": 4
    }
  },
  {
    "qid": "52df8ce798d023950500000d",
    "question": "Which are the supplemental antioxidant in athletes?",
    "answer-types": {
      "Melatonin": [
        "umls:orch",
        "umls:horm",
        "umls:phsu"
      ],
      "Rhodiola Rosea": [
        "umls:plnt"
      ],
      "Astaxanthin": [
        "umls:orch",
        "umls:phsu"
      ],
      "eicosapentanoic acid": [
        "umls:orch",
        "umls:bacs",
        "umls:phsu"
      ],
      "n-3 fatty acids": [
        "umls:orch",
        "umls:bacs",
        "umls:phsu"
      ],
      "L. rhamnosus IMC 501": [],
      "Creatine": [
        "umls:bacs",
        "umls:aapp"
      ],
      "docosahexanoic acid (DHA)": [
        "umls:orch",
        "umls:phsu"
      ],
      "Zinc": [
        "umls:elii",
        "umls:bacs",
        "umls:phsu"
      ],
      "Biostimine": [],
      "whey and/or soy proteins": [],
      "Epigallocatechin gallate": [
        "umls:orch",
        "umls:phsu"
      ],
      "eicosapentanoic acid (EPA)": [
        "umls:orch",
        "umls:bacs",
        "umls:phsu"
      ],
      "Vitamin E": [
        "umls:vita",
        "umls:orch",
        "umls:phsu"
      ],
      "Resveratrol": [
        "umls:orch",
        "umls:phsu"
      ],
      "Vitamin C": [
        "umls:vita",
        "umls:orch",
        "umls:phsu"
      ],
      "EPA": [
        "umls:orch",
        "umls:bacs",
        "umls:phsu"
      ],
      "Quercetin": [
        "umls:vita",
        "umls:orch",
        "umls:phsu"
      ],
      "Isoquercetin": [
        "umls:orch",
        "umls:phsu"
      ],
      "DHA": [
        "umls:bodm",
        "umls:orch",
        "umls:phsu"
      ],
      "docosahexanoic acid": [
        "umls:orch",
        "umls:phsu"
      ],
      "coenzyme Q(10)": [
        "umls:clnd"
      ],
      "L. paracasei IMC 502": []
    },
    "type-counts": {
      "umls:elii": 1,
      "umls:bodm": 1,
      "umls:vita": 3,
      "umls:plnt": 1,
      "umls:orch": 15,
      "umls:horm": 1,
      "umls:bacs": 6,
      "umls:clnd": 1,
      "umls:aapp": 1,
      "umls:phsu": 16
    }
  },
  {
    "qid": "552421082c8b63434a000005",
    "question": "What is the enzymatic activity of the breast cancer associated gene BRCA1?",
    "answer-types": {
      "E3 ubiquitin ligase activity": []
    },
    "type-counts": {}
  },
  {
    "qid": "5505b9ff8e1671127b000001",
    "question": "List markers for autophagy.",
    "answer-types": {
      "microtubule-associated protein 1 light chain 3": [
        "umls:aapp"
      ],
      "BECN1": [
        "umls:gngm"
      ],
      "beclin 1": [
        "umls:gngm"
      ],
      "LC3-II": [
        "umls:aapp"
      ],
      "SQSTM1": [
        "umls:gngm"
      ],
      "p62": [
        "umls:gngm"
      ],
      "Sequestosome 1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 5,
      "umls:aapp": 2
    }
  },
  {
    "qid": "5719f5b27de986d80d00000c",
    "question": "What is the function of Neu5Gc (N-Glycolylneuraminic acid)?",
    "answer-types": {
      "Neu5Gc is an immune message to self": []
    },
    "type-counts": {}
  },
  {
    "qid": "5710a592cf1c32585100002a",
    "question": "Which metabolite activates AtxA?",
    "answer-types": {
      "CO2": [
        "umls:inch",
        "umls:bacs"
      ],
      "bicarbonate": [
        "umls:inch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:inch": 2,
      "umls:bacs": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "532366f09b2d7acc7e000015",
    "question": "Which amino acid residue appears mutated in most of the cases reported with cadasil syndrome?",
    "answer-types": {
      "Cysteine": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "57090784cf1c325851000011",
    "question": "Which syndromes are associated with mutations in the EZH2 gene?",
    "answer-types": {
      "AA": [
        "umls:shro"
      ],
      "Acquired aplastic anemia": [
        "umls:dsyn"
      ],
      "NHL": [
        "umls:neop"
      ],
      "non-Hodgkin lymphoma (NHL)": [
        "umls:neop"
      ],
      "myeloid leukaemia": [
        "umls:neop"
      ],
      "Weaver syndrome": [
        "umls:dsyn"
      ],
      "non-Hodgkin lymphoma": [
        "umls:neop"
      ],
      "myelodysplastic syndrome": [
        "umls:neop"
      ],
      "Acquired aplastic anemia (AA)": [
        "umls:dsyn"
      ],
      "myelodysplastic syndrome (MDS)": [
        "umls:neop"
      ],
      "MDS": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:shro": 1,
      "umls:bpoc": 1,
      "umls:neop": 6,
      "umls:dsyn": 3
    }
  },
  {
    "qid": "55414a763f2354b713000003",
    "question": "Which databases exist for experimentally determined topologies of α-helical transmembrane proteins ?",
    "answer-types": {
      "TMPDB": [],
      "ExTopoDB": []
    },
    "type-counts": {}
  },
  {
    "qid": "52ed795098d0239505000032",
    "question": "Is the transcriptional regulator BACH1 an activator or a repressor?",
    "answer-types": {
      "Repressor": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "55000cc4e9bde69634000004",
    "question": "Which disease is characterized by congenital absence of intrinsic ganglion cells of the gastrointestinal tract?",
    "answer-types": {
      "Aganlionic megacolon or Hirschsprung disease": []
    },
    "type-counts": {}
  },
  {
    "qid": "54ede28094afd61504000003",
    "question": "What is the disease in which patients are sensitive to DNA crosslinking agents, presenting with a high frequency of chromosomal aberrations?",
    "answer-types": {
      "Fanconi anemia": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "56ecfd572ac5ed1459000002",
    "question": "How is oprozomib administered?",
    "answer-types": {
      "Orally": [
        "umls:bsoj"
      ]
    },
    "type-counts": {
      "umls:bsoj": 1
    }
  },
  {
    "qid": "56ebfa13107309bc2f000004",
    "question": "Which are the roles of chromatin compartments in the eukaryotic nucleus?",
    "answer-types": {
      "efficient trancription": [],
      "providing complex regulation": [],
      "facilitating matching genes and regulatory elements": []
    },
    "type-counts": {}
  },
  {
    "qid": "533c2230c45e133714000002",
    "question": "What are the biological roles proposed for proteins containing the SPRY domain?",
    "answer-types": {
      "embryonic development": [
        "umls:ortf"
      ],
      "immunity": [
        "umls:phsf"
      ],
      "vesicular trafficking": [
        "umls:celf"
      ],
      "defence against retroviral infection": [],
      "neural differentiation": [
        "umls:celf"
      ]
    },
    "type-counts": {
      "umls:celf": 2,
      "umls:ortf": 1,
      "umls:phsf": 1
    }
  },
  {
    "qid": "514241fcd24251bc05000006",
    "question": "The protein NONO forms heterodimers. With which proteins?",
    "answer-types": {
      "SFPQ": [
        "umls:bacs",
        "umls:aapp"
      ],
      "PSPC1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5709ee36cf1c32585100001e",
    "question": "Which syndrome is associated with mutant DVL1?",
    "answer-types": {
      "Robinow syndrome": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54d649843706e89528000009",
    "question": "What is the target of the drug Olaparib?",
    "answer-types": {
      "poly(ADP-ribose) polymerase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "PARP": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "56f802ea09dd18d46b000017",
    "question": "List human proteins that are subject to a dimer-to-tetramer transition.",
    "answer-types": {
      "SHMT2": [
        "umls:gngm"
      ],
      "Orai3": [
        "umls:gngm"
      ],
      "GAC": [
        "umls:inpr"
      ],
      "Orai1": [
        "umls:gngm"
      ],
      "AMPAR": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:inpr": 1,
      "umls:rcpt": 1,
      "umls:gngm": 3,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5335c7f2d6d3ac6a34000051",
    "question": "Inhibition of which transporter is the mechanism of action of drug Canagliflozin?",
    "answer-types": {
      "sodium glucose co-transporter 2": [
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:phsu": 1
    }
  },
  {
    "qid": "531b2fc3b166e2b80600003c",
    "question": "What is the prognostic role of thyroid hormone in patients with heart failure?",
    "answer-types": {
      "There is a relationship between altered thyroid profile and mortality in patients with heart failure": []
    },
    "type-counts": {}
  },
  {
    "qid": "531376c8e3eabad021000012",
    "question": "which mutations of phospholamban gene have been found to cause hypertrophic cardiomyopathy?",
    "answer-types": {
      "PLN -42 C\u003eG": [],
      "PLN L39X nonsense mutation": [],
      "PLN Leu39Ter": [
        "umls:gngm"
      ],
      "PLN -77A--\u003eG": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 2
    }
  },
  {
    "qid": "5545186cbf90a13052000002",
    "question": "Which gene strand is targeted by transcription-coupled repair (TCR)?",
    "answer-types": {
      "the transcribed strand": []
    },
    "type-counts": {}
  },
  {
    "qid": "5312280ce3eabad02100000a",
    "question": "Abnormalities in which chromosomes were linked to the Moyamoya disease?",
    "answer-types": {
      "12": [
        "umls:qnco"
      ],
      "3": [
        "umls:qnco"
      ],
      "15": [
        "umls:bpoc"
      ],
      "6": [
        "umls:bpoc"
      ],
      "17": [
        "umls:bpoc"
      ],
      "X": [
        "umls:bpoc"
      ],
      "8": [
        "umls:qnco"
      ],
      "Y": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "21": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 5,
      "umls:bacs": 1,
      "umls:phsu": 1,
      "umls:aapp": 1,
      "umls:qnco": 3
    }
  },
  {
    "qid": "5357a6d0f1005d6b58000004",
    "question": "Which is the branch site consensus sequence in U12-dependent introns?",
    "answer-types": {
      "UUCCUUAAC": []
    },
    "type-counts": {}
  },
  {
    "qid": "5710ade4cf1c32585100002c",
    "question": "What is the suggested therapy for Mycobacterium avium infection?",
    "answer-types": {
      "Rifampin 10 mg/kg daily, ciprofloxacin 500 mg twice daily, clofazimine 100 mg every day, and ethambutol 15 mg/kg orally daily for 24 weeks, with or without amikacin 10 mg/kg intravenously or intramuscularly 5 days weekly for the first 4 weeks": []
    },
    "type-counts": {}
  },
  {
    "qid": "56ed14d92ac5ed145900000a",
    "question": "What is the genetic basis of tuberous sclerosis?",
    "answer-types": {
      "TSC1 and TSC2 genes": []
    },
    "type-counts": {}
  },
  {
    "qid": "57092332cf1c325851000018",
    "question": "What is the molecular function of the Chd1 protein?",
    "answer-types": {
      "Chd1 is an ATP-dependent DNA helicase": []
    },
    "type-counts": {}
  },
  {
    "qid": "54df69af1388e8454a000005",
    "question": "Which drugs are included in the FEC-75 regimen?",
    "answer-types": {
      "cyclophosphamide": [
        "umls:orch",
        "umls:phsu"
      ],
      "epirubicin": [
        "umls:orch",
        "umls:phsu"
      ],
      "fluorouracil": [
        "umls:nnon",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:orch": 2,
      "umls:phsu": 3
    }
  },
  {
    "qid": "5536554abc4f83e828000008",
    "question": "Between which probes does the recurrent translocation breakpoint on chromosome 22 of neuroepithelioma lie?",
    "answer-types": {
      "D22S15": [],
      "D22S1": []
    },
    "type-counts": {}
  },
  {
    "qid": "56f3f0f02ac5ed1459000017",
    "question": "Which are the most widely used computational methods for the identification of CRMs (cis-regulatory modules)?",
    "answer-types": {
      "combinatorial methods": [],
      "motif conservation": [],
      "fuzzy itemset mining": []
    },
    "type-counts": {}
  },
  {
    "qid": "56ed03862ac5ed1459000004",
    "question": "Which enzyme does MLN4924 inhibit?",
    "answer-types": {
      "NEDD8-activating enzyme": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "535d3c069a4572de6f000006",
    "question": "What is the number of protein coding genes in the human genome?",
    "answer-types": {
      "Between 20,000 and 25,000": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "54f9cb34dd3fc62544000002",
    "question": "Which protein has been found to interact with phospholamban (PLN) and is also an anti-apoptotic protein?",
    "answer-types": {
      "The HS-1 associated protein X-1": [],
      "(HAX-1)": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "515df063298dcd4e51000029",
    "question": "What is the indication for prophylactic use of antibiotics in COPD?",
    "answer-types": {
      "Reduction of number of exacerbations": []
    },
    "type-counts": {}
  },
  {
    "qid": "515db083298dcd4e51000012",
    "question": "How many genes does the human hoxD cluster contain?",
    "answer-types": {
      "9": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "54d73e223706e89528000010",
    "question": "What is the generic name of Gliolan?",
    "answer-types": {
      "5-aminolevulinic acid": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "55058af6f73303d458000004",
    "question": "Which protein is the E3-ubiquitin ligase that targets the tumor suppressor p53 for proteasomal degradation?",
    "answer-types": {
      "The mouse double minute 2": [
        "umls:gngm"
      ],
      "Hdm2": [
        "umls:gngm"
      ],
      "The human homologue of Mdm2 (Hdm2)": [],
      "The human homologue of Mdm2": [],
      "The mouse double minute 2 (mdm2)": [
        "umls:gngm"
      ],
      "mdm2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 4
    }
  },
  {
    "qid": "5156be75d24251bc05000088",
    "question": "Which diseases is microRNA 132 (miR-132) implicated in?",
    "answer-types": {
      "epilepsy": [
        "umls:dsyn"
      ],
      "CLL": [
        "umls:neop"
      ],
      "neurodegenerative disease": [
        "umls:dsyn"
      ],
      "AD": [
        "umls:qlco"
      ],
      "chronic lymphocytic leukemia (CLL)": [
        "umls:neop"
      ],
      "angiogenesis": [
        "umls:ortf"
      ],
      "Alzheimer\u0027s disease (AD)": [
        "umls:dsyn"
      ],
      "schizophrenia": [
        "umls:mobd"
      ],
      "Huntington\u0027s disease": [
        "umls:dsyn"
      ],
      "PSP taupathy": [],
      "alcoholic liver disease": [
        "umls:dsyn"
      ],
      "chronic lymphocytic leukemia": [
        "umls:neop"
      ],
      "neuroinflammation": [],
      "progressive supranuclear palsy (PSP taupathy)": [
        "umls:dsyn"
      ],
      "mild cognitive impairment": [
        "umls:mobd"
      ],
      "eye disease": [
        "umls:dsyn"
      ],
      "HD": [
        "umls:patf"
      ],
      "Huntington\u0027s disease (HD)": [
        "umls:dsyn"
      ],
      "Alzheimer\u0027s disease": [
        "umls:dsyn"
      ],
      "osteosarcoma": [
        "umls:neop"
      ],
      "progressive supranuclear palsy": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:mobd": 2,
      "umls:qlco": 1,
      "umls:neop": 4,
      "umls:ortf": 1,
      "umls:dsyn": 10
    }
  },
  {
    "qid": "57169b63cb4ef8864c00000b",
    "question": "Which are the human glutamate transporters?",
    "answer-types": {
      "GLAST": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Glutamate/aspartate transporter": [
        "umls:bacs",
        "umls:aapp"
      ],
      "AMPA receptor glutamate receptor 4": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "vesicular glutamate transporter": [
        "umls:bacs",
        "umls:aapp"
      ],
      "glutamate transporter-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "EAAC1": [
        "umls:gngm"
      ],
      "GluR4": [
        "umls:gngm"
      ],
      "VGLUT1": [
        "umls:gngm"
      ],
      "excitatory amino acid transporter 1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "EAAT3": [
        "umls:gngm"
      ],
      "GLT-1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:rcpt": 1,
      "umls:gngm": 5,
      "umls:bacs": 5,
      "umls:aapp": 6
    }
  },
  {
    "qid": "535d35779a4572de6f000005",
    "question": "What is the proportion of non canonical splice sites in the human genome?",
    "answer-types": {
      "Between 1% and 2%": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "55184d46622b194345000001",
    "question": "List protein gel staining methods visualizing the entire protein set.",
    "answer-types": {
      "Coomassie Brilliant Blue": [
        "umls:irda",
        "umls:orch",
        "umls:phsu"
      ],
      "Coomassie Blue": [
        "umls:orch",
        "umls:phsu"
      ],
      "Sypro Ruby": [
        "umls:orch"
      ],
      "fluorescence": [
        "umls:npop"
      ],
      "fluorochromes": [
        "umls:irda"
      ],
      "Silver staining": [
        "umls:lbpr"
      ],
      "Colloidal Coomassie Blue": []
    },
    "type-counts": {
      "umls:npop": 1,
      "umls:irda": 2,
      "umls:orch": 3,
      "umls:lbpr": 1,
      "umls:phsu": 2
    }
  },
  {
    "qid": "56b7083376d8bf8d13000001",
    "question": "What is the causative agent of the \"Panama disease\" affecting bananas?",
    "answer-types": {
      "Fusarium oxysporum f. sp. cubense": []
    },
    "type-counts": {}
  },
  {
    "qid": "54cf43abf693c3b16b000008",
    "question": "Synostosis of which cranial structures are characteristic to the Mercedes Benz syndrome?",
    "answer-types": {
      "lambdoid": [
        "umls:fndg"
      ],
      "sagittal": [
        "umls:spco"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:spco": 1
    }
  },
  {
    "qid": "55391ce8bc4f83e828000018",
    "question": "Which signaling pathways have been associated with medulloblastoma formation and growth?",
    "answer-types": {
      "TrkC": [
        "umls:gngm"
      ],
      "erbB2": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "Hedgehog": [
        "umls:mamm"
      ],
      "Myc": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Notch": [
        "umls:bsoj"
      ],
      "c-Met": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "IGF-R": [
        "umls:aapp"
      ],
      "Wnt": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bsoj": 1,
      "umls:enzy": 1,
      "umls:mamm": 1,
      "umls:rcpt": 2,
      "umls:bacs": 2,
      "umls:gngm": 1,
      "umls:aapp": 5
    }
  },
  {
    "qid": "51542dc3d24251bc0500007e",
    "question": "What are the symptoms of abacavir hypersensitivity?",
    "answer-types": {
      "enathema": [],
      "skin rash": [
        "umls:sosy"
      ],
      "gastrointestinal disorders": [
        "umls:dsyn"
      ],
      "respiratory symptoms": [
        "umls:sosy"
      ],
      "anaphylactic shock": [
        "umls:patf"
      ],
      "fever": [
        "umls:sosy"
      ],
      "cough": [
        "umls:sosy"
      ],
      "diarrhea": [
        "umls:sosy"
      ],
      "vomiting": [
        "umls:sosy"
      ],
      "nausea": [
        "umls:sosy"
      ]
    },
    "type-counts": {
      "umls:sosy": 7,
      "umls:patf": 1,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "55376663bc4f83e82800000a",
    "question": "Which biomarker is widely used in the diagnosis of Ewing sarcoma?",
    "answer-types": {
      "CD99": [
        "umls:imft",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "51595fb0d24251bc0500009c",
    "question": "Proteomic analyses have revealed proteins associated with the triple-negative breast cancers. List some proposed proteins.",
    "answer-types": {
      "beta-catenin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "14-3-3": [
        "umls:bacs",
        "umls:aapp"
      ],
      "CD74": [
        "umls:imft",
        "umls:aapp"
      ],
      "HSP70": [
        "umls:bacs",
        "umls:aapp"
      ],
      "PARP1": [
        "umls:gngm"
      ],
      "CRABP2": [
        "umls:gngm"
      ],
      "MUC18": [
        "umls:gngm"
      ],
      "IDH2": [
        "umls:gngm"
      ],
      "LSR": [
        "umls:gngm"
      ],
      "vimentin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "SEC14L2": [
        "umls:gngm"
      ],
      "CK18": [
        "umls:gngm"
      ],
      "Hsp90": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Mage-A4": [
        "umls:imft",
        "umls:aapp"
      ],
      "MUC1": [
        "umls:gngm"
      ],
      "RAB25": [
        "umls:gngm"
      ],
      "Actin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "moesin": [
        "umls:aapp"
      ],
      "Stat1": [
        "umls:gngm"
      ],
      "S100A14": [
        "umls:gngm"
      ],
      "CD44": [
        "umls:imft",
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 3,
      "umls:rcpt": 1,
      "umls:gngm": 11,
      "umls:bacs": 6,
      "umls:aapp": 10
    }
  },
  {
    "qid": "52f11b922059c6d71c000004",
    "question": "Which signalling pathway is involved in Tuberous Sclerosis?",
    "answer-types": {
      "Tuberous Sclerosis is caused by hyperactivation of the mTOR signalling pathway.": []
    },
    "type-counts": {}
  },
  {
    "qid": "536787467d100faa09000010",
    "question": "Which is the relation between sweating and anaerobic threshold?",
    "answer-types": {
      "There is no clear evidence of the relationship between sweating and anaerobic threshold": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c077e9ef6e394741000021",
    "question": "Name monoclonal antibody against SLAMF7.",
    "answer-types": {
      "signaling lymphocytic activation molecule-F7": []
    },
    "type-counts": {}
  },
  {
    "qid": "5547d700f35db75526000007",
    "question": "Which are the major types of the motor speech disorder dysarthria?",
    "answer-types": {
      "spastic dysarthria": [
        "umls:fndg"
      ],
      "hyperkinetic dysarthria": [
        "umls:dsyn"
      ],
      "mixed dysarthria": [
        "umls:fndg"
      ],
      "ataxic dysarthria": [
        "umls:fndg"
      ],
      "hypokinetic dysarthria": [
        "umls:dsyn"
      ],
      "flaccid dysarthria": [
        "umls:sosy"
      ]
    },
    "type-counts": {
      "umls:fndg": 3,
      "umls:sosy": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "571f609c0fd6f91b6800000c",
    "question": "Which enzyme deficiency can cause GM1 gangliosidoses?",
    "answer-types": {
      "β-galactosidase": [
        "umls:enzy",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "55032e65e9bde69634000034",
    "question": "What is the characteristic feature of the Dyke-Davidoff-Masson syndrome.",
    "answer-types": {
      "cerebral hemiatrophy": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "5717d86029809bbe7a000003",
    "question": "Which gene is involved in the development of Barth syndrome?",
    "answer-types": {
      "Tafazzin": [
        "umls:gngm"
      ],
      "Tafazzin (TAZ) gene": [
        "umls:gngm"
      ],
      "TAZ": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 1,
      "umls:gngm": 2
    }
  },
  {
    "qid": "531b1e3cb166e2b80600003b",
    "question": "Which histone modifications are associated with Polycomb group (PcG) proteins?",
    "answer-types": {
      "H3K9me3": [],
      "H3K27Ac": [
        "umls:aapp"
      ],
      "H3K36me": [
        "umls:moft"
      ],
      "H3K27me3": [
        "umls:moft"
      ]
    },
    "type-counts": {
      "umls:moft": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52d832dd98d0239505000003",
    "question": "List phosphorylation consensus motifs for Casein Kinase 1 (CK1)?",
    "answer-types": {
      "K/R-X-K/R-X-X-S/T": [],
      "SLS and acidic cluster motifs": [],
      "pSer-Xaa-Xaa-Ser": [],
      "SerP/ThrP-Xaa-Xaa-Ser/Thr": []
    },
    "type-counts": {}
  },
  {
    "qid": "56bb616dac7ad10019000008",
    "question": "What medication were compared in the ROCKET AF Trial?",
    "answer-types": {
      "rivaroxaban": [
        "umls:orch",
        "umls:phsu"
      ],
      "warfarin": [
        "umls:hops",
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:hops": 1,
      "umls:orch": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "56b3a3ce8525abca1e000005",
    "question": "List proteins of lipids droplets",
    "answer-types": {
      "lipid storage droplet protein 5": [
        "umls:gngm"
      ],
      "ADFP": [
        "umls:gngm"
      ],
      "S3-12": [
        "umls:gngm"
      ],
      "LSDP5": [
        "umls:gngm"
      ],
      "tail-interacting protein of 47 kilodaltons": [],
      "perilipins": [
        "umls:bacs",
        "umls:aapp"
      ],
      "TIP47": [
        "umls:gngm"
      ],
      "adipose differentiation-related protein": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 2,
      "umls:gngm": 5,
      "umls:aapp": 2
    }
  },
  {
    "qid": "514a0f4ad24251bc05000053",
    "question": "How many genes are in the gene signature screened by MammaPrint?",
    "answer-types": {
      "70 genes": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "51651e24298dcd4e51000054",
    "question": "How many genera comprise the Flaviviridae family?",
    "answer-types": {
      "3": [
        "_QUANTITY"
      ],
      "three": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 2
    }
  },
  {
    "qid": "535d59349a4572de6f000009",
    "question": "What are the indications for treatment with anti-hepcidin?",
    "answer-types": {
      "anemia of inflammation": [
        "umls:dsyn"
      ],
      "iron-restricted anemias": [],
      "anemia of chronic disease": [
        "umls:dsyn"
      ],
      "anemia of cancer": [
        "umls:dsyn"
      ],
      "anemia of chronic kidney disease": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 4
    }
  },
  {
    "qid": "56c1d84cef6e394741000031",
    "question": "List functions that are evaluated with the Full Outline of Unresponsiveness score?",
    "answer-types": {
      "brainstem reflexes": [
        "umls:fndg"
      ],
      "motor responses": [
        "umls:clna"
      ],
      "respiration": [
        "umls:phsf"
      ],
      "eye responses": [
        "umls:fndg"
      ]
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:clna": 1,
      "umls:phsf": 1
    }
  },
  {
    "qid": "5713bf261174fb1755000011",
    "question": "For the constructions of which organs has 3D printing been tested?",
    "answer-types": {
      "nose": [
        "umls:bpoc"
      ],
      "meniscus": [
        "umls:bpoc"
      ],
      "ear": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 3
    }
  },
  {
    "qid": "52fbe2bf2059c6d71c00006c",
    "question": "Where is the histone variant CENPA preferentially localized?",
    "answer-types": {
      "CENPA is preferentially localized in eukaryotic centromeres": []
    },
    "type-counts": {}
  },
  {
    "qid": "52b2e498f828ad283c000010",
    "question": "Mutation of which gene is associated with Achondroplasia?",
    "answer-types": {
      "fibroblast growth factor receptor 3": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "fibroblast growth factor receptor 3 (FGFR3)": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "FGFR3": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:rcpt": 3,
      "umls:aapp": 3
    }
  },
  {
    "qid": "5147c088d24251bc05000026",
    "question": "Which type of lung cancer is the most strongly associated with Lambert-Eaton syndrome?",
    "answer-types": {
      "small-cell lung cancer": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "5719f5c67de986d80d00000d",
    "question": "What distinguishes lantibiotics from antibiotics?",
    "answer-types": {
      "Lantibiotics are post-translationally modified natural peptides containing lanthionine": []
    },
    "type-counts": {}
  },
  {
    "qid": "5503263fe9bde69634000030",
    "question": "List three major features of the CCFDN syndrome.",
    "answer-types": {
      "congenital cataracts": [
        "umls:cgab"
      ],
      "peripheral neuropathy": [
        "umls:dsyn"
      ],
      "facial dysmorphism": [
        "umls:cgab"
      ]
    },
    "type-counts": {
      "umls:cgab": 2,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "5309f8f5970c65fa6b000001",
    "question": "Which oncogenes are able to induce cellular senescence?",
    "answer-types": {
      "Caveolin-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "HDAC2": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Ras": [
        "umls:gngm"
      ],
      "Myc": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Raf": [
        "umls:gngm"
      ],
      "c-Abl": [
        "umls:gngm"
      ],
      "AKT": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Mek1": [
        "umls:enzy",
        "umls:aapp"
      ],
      "BRAF": [
        "umls:gngm"
      ],
      "Skp2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "p38 MAPK": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 4,
      "umls:gngm": 4,
      "umls:bacs": 3,
      "umls:aapp": 7
    }
  },
  {
    "qid": "517901bc8ed59a060a00003b",
    "question": "The antibodies MK-3475 and CT-011 have shown promising results in treating malignancies. Which protein are they targeting?",
    "answer-types": {
      "PD-1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "5517f9286487737b43000002",
    "question": "Which are the different proteins/isoforms encoded but the ASPH (aspartate beta-hydroxylase) gene in humans?",
    "answer-types": {
      "junctin": [
        "umls:gngm"
      ],
      "Aspartyl (asparaginyl)-beta-hydroxylase": [
        "umls:aapp"
      ],
      "Aspartyl-beta-hydroxylase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "AbetaH": [],
      "AAH": [
        "umls:aapp"
      ],
      "BAH": [
        "umls:gngm"
      ],
      "junctate": [
        "umls:gngm"
      ],
      "Aspartyl": [
        "umls:aapp"
      ],
      "asparaginyl": [
        "umls:aapp"
      ],
      "junctin isoform": [],
      "humbug": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:gngm": 4,
      "umls:aapp": 5
    }
  },
  {
    "qid": "56d1d94667f0cb3d66000005",
    "question": "List processes which are under the control of the YAP protein.",
    "answer-types": {
      "cell differentiation": [
        "umls:celf"
      ],
      "organ size control": [],
      "cell proliferation": [
        "umls:celf"
      ],
      "cancer development": [
        "umls:resa"
      ],
      "tissue homeostasis": [
        "umls:orgf"
      ]
    },
    "type-counts": {
      "umls:celf": 2,
      "umls:orgf": 1,
      "umls:resa": 1
    }
  },
  {
    "qid": "54e0e902ae9738404b000001",
    "question": "What family do mDia proteins belong in?",
    "answer-types": {
      "mDia proteins are members of the formin family": []
    },
    "type-counts": {}
  },
  {
    "qid": "554356d0ed966d112c000005",
    "question": "Which is the most common measure of differences between dinucleotide relative abundance \"genomic signatures\"",
    "answer-types": {
      "delta-distance": []
    },
    "type-counts": {}
  },
  {
    "qid": "532206819b2d7acc7e00000f",
    "question": "Name a method for enrichment of arginine-methylated peptides.",
    "answer-types": {
      "Immunoaffinity purification": []
    },
    "type-counts": {}
  },
  {
    "qid": "56d29d4df22319765a000003",
    "question": "List omics technologies comprised in system biology.",
    "answer-types": {
      "degradomics": [],
      "fluxomics": [],
      "proteomics": [
        "umls:bmod"
      ],
      "metabolomics": [
        "umls:bmod"
      ],
      "glucomics": [],
      "transcriptomics": [],
      "genomics": [
        "umls:bmod"
      ],
      "epigenomics": [
        "umls:bmod"
      ]
    },
    "type-counts": {
      "umls:bmod": 4
    }
  },
  {
    "qid": "54d8fd334b1fd0d33c000005",
    "question": "Rindopepimut is an analog of which growth factor?",
    "answer-types": {
      "EGFRvIII": [
        "umls:rcpt"
      ]
    },
    "type-counts": {
      "umls:rcpt": 1
    }
  },
  {
    "qid": "52ea605098d0239505000028",
    "question": "Which gene mutations are responsible for isolated Non-compaction cardiomyopathy?",
    "answer-types": {
      "DSP": [
        "umls:orch",
        "umls:phsu"
      ],
      "β-myosin heavy chain": [],
      "troponin T": [
        "umls:bacs",
        "umls:aapp"
      ],
      "alpha-tropomyosin": [
        "umls:aapp"
      ],
      "TNNT2": [
        "umls:gngm"
      ],
      "Desmoplakin": [
        "umls:aapp"
      ],
      "mindbomb homolog 1": [
        "umls:gngm"
      ],
      "TPM1": [
        "umls:gngm"
      ],
      "MYH7": [
        "umls:gngm"
      ],
      "MIB1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:gngm": 5,
      "umls:bacs": 1,
      "umls:aapp": 3,
      "umls:phsu": 1
    }
  },
  {
    "qid": "52f350042059c6d71c000010",
    "question": "What is the incidence of Edwards syndrom in the european population?",
    "answer-types": {
      "1:5000": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "52f89fc62059c6d71c000050",
    "question": "From which tissue was the NCI-H520 cell-line derived?",
    "answer-types": {
      "Squamous cell carcinoma": [
        "umls:neop"
      ],
      "Non-small cell lung cancer": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 2
    }
  },
  {
    "qid": "54f60ae05f206a0c06000008",
    "question": "What is the substrate of the microbial enzyme inulinase?",
    "answer-types": {
      "The inulinase acts on the beta-(2,1)-D-fructoside links in inulin releasing D-fructose.": []
    },
    "type-counts": {}
  },
  {
    "qid": "517a8cc68ed59a060a000044",
    "question": "What is the treatment of acute myocarditis?",
    "answer-types": {
      "inotropic agents": [
        "umls:phsu"
      ],
      "mechanical support": [
        "umls:topp"
      ],
      "antiinflammatory steroid and non steroid drugs": []
    },
    "type-counts": {
      "umls:topp": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "5318367cb166e2b806000012",
    "question": "List causative genes for autosomal recessive forms of monogenic Parkinson\u0027s disease",
    "answer-types": {
      "PARK15": [
        "umls:gngm"
      ],
      "PINK1": [
        "umls:gngm"
      ],
      "PARK14": [
        "umls:gngm"
      ],
      "PARK9": [
        "umls:dsyn"
      ],
      "FBX07": [],
      "ATP13A2": [
        "umls:gngm"
      ],
      "DJ-1": [
        "umls:gngm"
      ],
      "PARK7": [
        "umls:bacs",
        "umls:aapp"
      ],
      "PLA2G6": [
        "umls:gngm"
      ],
      "PARK2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1,
      "umls:bacs": 1,
      "umls:gngm": 7,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52e8e98298d0239505000020",
    "question": "Which diseases are caused by mutations in Calsequestrin 2 (CASQ2) gene?",
    "answer-types": {
      "HCM": [
        "umls:hlca"
      ],
      "catecholaminergic polymorphic ventricular tachycardia": [
        "umls:dsyn"
      ],
      "CPVT": [
        "umls:irda"
      ],
      "hypertrophic cardiomyopathy": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:irda": 1,
      "umls:dsyn": 2,
      "umls:hlca": 1
    }
  },
  {
    "qid": "5324a8ac9b2d7acc7e000018",
    "question": "What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?",
    "answer-types": {
      "BCR-ABL": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "571e172bbb137a4b0c000002",
    "question": "When was empagliflozin FDA approved?",
    "answer-types": {
      "2014": [
        "umls:orch"
      ]
    },
    "type-counts": {
      "umls:orch": 1
    }
  },
  {
    "qid": "56b330bb39c782df06000001",
    "question": "Which R/bioconductor package is used for integrative genomics visualizations?",
    "answer-types": {
      "Sushi.R": []
    },
    "type-counts": {}
  },
  {
    "qid": "57090c33cf1c325851000013",
    "question": "How many genes are imprinted in the human genome?",
    "answer-types": {
      "fewer than 100": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "56be06cdef6e394741000004",
    "question": "List symptoms of congenital toxoplasmosis triad.",
    "answer-types": {
      "cerebral calcification": [
        "umls:fndg"
      ],
      "hydrocephalus": [
        "umls:dsyn"
      ],
      "chorioretinitis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "515d1ff7298dcd4e51000009",
    "question": "Which cellular processes are regulated by Nanog?",
    "answer-types": {
      "cell proliferation": [
        "umls:celf"
      ],
      "tumour development": [],
      "germ cell migration": [
        "umls:celf"
      ],
      "G1 to S transition": [
        "umls:celf"
      ],
      "cell fate determination": [
        "umls:celf"
      ],
      "pluripotency": [
        "umls:orgf"
      ]
    },
    "type-counts": {
      "umls:celf": 4,
      "umls:orgf": 1
    }
  },
  {
    "qid": "56ed27202ac5ed145900000c",
    "question": "In which cells are A-type lamins expressed?",
    "answer-types": {
      "late differentiating primary cells": []
    },
    "type-counts": {}
  },
  {
    "qid": "5157539ed24251bc0500008a",
    "question": "Gene silencing can be achieved by RNA interference (RNAi) in eukaryotic organisms. What is the name of the analogous process in prokaryotic organisms?",
    "answer-types": {
      "CRISPR-Cas": [
        "umls:orgf"
      ]
    },
    "type-counts": {
      "umls:orgf": 1
    }
  },
  {
    "qid": "530cf4e0c8a0b4a00c000004",
    "question": "Which mutations of alpha-myosin heavy chain gene are implicated in hypertrophic cardiomyopathy?",
    "answer-types": {
      "R403Q": [],
      "Arg-249--\u003eGln": [],
      "Arg403Gln": [
        "umls:gngm"
      ],
      "Q1065H": []
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "530cf4e0c8a0b4a00c000005",
    "question": "Which are the cardiac manifestations of Marfan syndrome?",
    "answer-types": {
      "aortic regurgitation": [
        "umls:dsyn"
      ],
      "mitral valve prolapse": [
        "umls:dsyn"
      ],
      "aortic root dilation": [
        "umls:dsyn"
      ],
      "mitral valve regurgitation": [
        "umls:patf"
      ]
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:dsyn": 3
    }
  },
  {
    "qid": "530cf4e0c8a0b4a00c000002",
    "question": "How is connected \"isolated Non-compaction cardiomyopathy\" with dilated cardiomyopathy?",
    "answer-types": {
      "via mutations in beta-MHC and alpha-TPM1": []
    },
    "type-counts": {}
  },
  {
    "qid": "530cf4e0c8a0b4a00c000006",
    "question": "Which is the most common cause of sudden cardiac death in young athletes?",
    "answer-types": {
      "hypertrophic cardiomyopathy": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "530cf4e0c8a0b4a00c000007",
    "question": "What is the rate of survival after commotio cordis?",
    "answer-types": {
      "10-28%": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "52e0141498d023950500000e",
    "question": "What are the results of loss of the protein Lon1 in the plant Arabidopsis?",
    "answer-types": {
      "impaired seedling establishment": [],
      "lowered activity of specific mitochondrial enzymes associated with respiratory metabolism": [],
      "growth rate deficit in both roots and shoots": []
    },
    "type-counts": {}
  },
  {
    "qid": "572096c90fd6f91b6800000e",
    "question": "Which gene is involved in Giant Axonal Neuropathy?",
    "answer-types": {
      "GAN gene": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "5173bdb38ed59a060a000020",
    "question": "How many TAp73 isoforms have been identified in humans?",
    "answer-types": {
      "7": [
        "_QUANTITY"
      ],
      "seven": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 2
    }
  },
  {
    "qid": "5518e817622b194345000006",
    "question": "Which are the different members/isoforms of the Ras oncogenes?",
    "answer-types": {
      "K-Ras4A": [
        "umls:gngm"
      ],
      "H-Ras": [
        "umls:gngm"
      ],
      "N-Ras": [
        "umls:gngm"
      ],
      "K-Ras4B": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 4
    }
  },
  {
    "qid": "53442ca9aeec6fbd0700000b",
    "question": "Which is the subcellular localization of ERAP2?",
    "answer-types": {
      "luminal side of the endoplasmic reticulum": []
    },
    "type-counts": {}
  },
  {
    "qid": "530cefaaad0bf1360c000003",
    "question": "What are the names of anti-CD52 monoclonal antibody that is used for treatment of multiple sclerosis patients?",
    "answer-types": {
      "Campath-1H": [
        "umls:orch",
        "umls:imft",
        "umls:phsu"
      ],
      "Alemtuzumab": [
        "umls:imft",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:imft": 2,
      "umls:aapp": 1,
      "umls:phsu": 2
    }
  },
  {
    "qid": "530cefaaad0bf1360c000002",
    "question": "Which brain structures have been investigated as potential targets for deep brain stimulation of patients suffering from major depression?",
    "answer-types": {
      "anterior limb of the capsula interna": [],
      "ventral caudate nucleus": [],
      "medial forebrain bundle": [
        "umls:bpoc"
      ],
      "nucleus accumbens": [
        "umls:bpoc"
      ],
      "habenula": [
        "umls:bpoc"
      ],
      "subgenual cingulate gyrus": []
    },
    "type-counts": {
      "umls:bpoc": 3
    }
  },
  {
    "qid": "530cefaaad0bf1360c000007",
    "question": "List anti-amyloid-beta monoclonal antibodies that have been investigated in clinical trials for treatment of Alzheimer disease.",
    "answer-types": {
      "solanezumab": [
        "umls:imft",
        "umls:aapp",
        "umls:phsu"
      ],
      "Gantenerumab": [
        "umls:imft",
        "umls:phsu"
      ],
      "bapineuzumab": [
        "umls:aapp",
        "umls:phsu"
      ],
      "ponezumab": [
        "umls:imft",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:imft": 3,
      "umls:phsu": 4,
      "umls:aapp": 2
    }
  },
  {
    "qid": "52ecf2dd98d023950500002e",
    "question": "Which deiodinase polymorphisms are implicated in arterial hypertension?",
    "answer-types": {
      "rs7140952 polymorphism of DIO2": [],
      "Ala92 type 2 deiodinase allele": []
    },
    "type-counts": {}
  },
  {
    "qid": "52efbfccc8da898910000018",
    "question": "At which kind of individuals is pharmacological treatment of subclinical hypothyroidism effective in reducing cardiovascular events?",
    "answer-types": {
      "effective in younger individuals": []
    },
    "type-counts": {}
  },
  {
    "qid": "52d63b2803868f1b0600003a",
    "question": "From which tissue was the NCI-H520 cell-line derived?",
    "answer-types": {
      "Lung": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 1
    }
  },
  {
    "qid": "5319abe4b166e2b80600002e",
    "question": "Which transcription factors are involved in E-cadherin repression during EMT?",
    "answer-types": {
      "Twist": [
        "umls:phsf"
      ],
      "Zeb1": [
        "umls:gngm"
      ],
      "SIP1": [
        "umls:gngm"
      ],
      "Snail1 (Snail)": [
        "umls:gngm"
      ],
      "Snail2 (Slug)": [
        "umls:gngm"
      ],
      "Snail1": [
        "umls:gngm"
      ],
      "Snail2": [
        "umls:gngm"
      ],
      "DeltaEF1": [
        "umls:gngm"
      ],
      "Snail": [
        "umls:euka"
      ],
      "Slug": [
        "umls:euka"
      ]
    },
    "type-counts": {
      "umls:euka": 2,
      "umls:phsf": 1,
      "umls:gngm": 7
    }
  },
  {
    "qid": "54ff30dc6ad7dcbc1200000f",
    "question": "List human diseases involving genomic imprinting.",
    "answer-types": {
      "Beckwith-Wiedemann syndrome": [
        "umls:dsyn"
      ],
      "Angelman syndrome": [
        "umls:dsyn"
      ],
      "Hydatidiform mole": [
        "umls:neop"
      ],
      "Silver-Russell syndrome": [
        "umls:dsyn"
      ],
      "Diabetes": [
        "umls:dsyn"
      ],
      "Cancer": [
        "umls:neop"
      ],
      "Prader Willi Syndrome": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:neop": 2,
      "umls:dsyn": 5
    }
  },
  {
    "qid": "530cefaaad0bf1360c000012",
    "question": "Which deficiency is the cause of restless leg syndrome?",
    "answer-types": {
      "iron": [
        "umls:elii",
        "umls:bacs",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:elii": 1,
      "umls:bacs": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "53398855d6d3ac6a3400005b",
    "question": "What histone modification is recognized by the bromodomain?",
    "answer-types": {
      "Acetylated lysines": []
    },
    "type-counts": {}
  },
  {
    "qid": "530cefaaad0bf1360c000011",
    "question": "What memory problems are reported in the \" Gulf war syndrome\"?",
    "answer-types": {
      "dysmnesia": [
        "umls:mobd"
      ],
      "loss of memory": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:mobd": 2
    }
  },
  {
    "qid": "55031628e9bde69634000024",
    "question": "Which neuroendocrine tumors are associated with specific tumor syndromes?",
    "answer-types": {
      "pheochromocytoma": [
        "umls:neop"
      ],
      "medullary thyroid carcinoma": [
        "umls:neop"
      ],
      "gastroenteropancreatic tumors": [],
      "paraganglioma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 3
    }
  },
  {
    "qid": "56d1da3b67f0cb3d66000006",
    "question": "How many periods of regulatory innovation led to the evolution of vertebrates?",
    "answer-types": {
      "Three": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "530cefaaad0bf1360c00000c",
    "question": "List medication interfering with purine metabolism that are used for treatment of T-cell prolymphocytic leukemia?",
    "answer-types": {
      "pentostatin": [
        "umls:nnon",
        "umls:antb"
      ],
      "deoxycoformycin": [
        "umls:nnon",
        "umls:antb"
      ],
      "nelarabine": [
        "umls:nnon",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:nnon": 3,
      "umls:antb": 2,
      "umls:phsu": 1
    }
  },
  {
    "qid": "530cefaaad0bf1360c00000d",
    "question": "Which hormone abnormalities are common in Williams syndrome ?",
    "answer-types": {
      "thyroid": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "56f6d11c09dd18d46b00000f",
    "question": "Which is the protein encoded by the human gene GRIK?",
    "answer-types": {
      "glutamate receptor ionotropic kainate": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "550c4011a103b78016000009",
    "question": "Which residue of alpha-synuclein was found to be phosphorylated in Lewy bodies?",
    "answer-types": {
      "Serine 129": []
    },
    "type-counts": {}
  },
  {
    "qid": "54d670163706e8952800000f",
    "question": "List Genes associated with adolescent idiopathic scoliosis",
    "answer-types": {
      "no associations found yet": []
    },
    "type-counts": {}
  },
  {
    "qid": "5324cf139b2d7acc7e00001f",
    "question": "List the off-label use of SSRIs",
    "answer-types": {
      "postmenopausal symptoms": [
        "umls:dsyn"
      ],
      "mood and anxiety disorders during pregnancy and breast feeding": [],
      "diabetic neuropathy": [
        "umls:dsyn"
      ],
      "chronic pain disease": [
        "umls:sosy"
      ],
      "SUI": [
        "umls:plnt"
      ],
      "depression during childhood and adolescence": [],
      "schizophrenia": [
        "umls:mobd"
      ],
      "erectile dysfunction": [
        "umls:fndg"
      ],
      "postprostatectomy established stress urinary incontinence": [],
      "Premature ejaculation": [
        "umls:mobd"
      ],
      "PE": [
        "umls:geoa"
      ],
      "fibromyalgia": [
        "umls:dsyn"
      ],
      "Insomnia": [
        "umls:sosy"
      ],
      "hot flashes": [
        "umls:sosy"
      ],
      "behavioral disorders in dementia": [
        "umls:mobd"
      ],
      "benzodiazepine/alcohol dependence": [],
      "bulimia": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:sosy": 3,
      "umls:mobd": 4,
      "umls:plnt": 1,
      "umls:dsyn": 3,
      "umls:geoa": 1
    }
  },
  {
    "qid": "54ff5197e9bde69634000001",
    "question": "How long, in kb (kilobases), is a \"Long interspersed nuclear element\"?",
    "answer-types": {
      "6-7 kb": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "56bc9268ac7ad1001900001b",
    "question": "What molecule is targeted by brodalumab?",
    "answer-types": {
      "Interleukin-17": [
        "umls:imft",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5343fc1aaeec6fbd07000003",
    "question": "Which is the gene mutated in type 1 neurofibromatosis?",
    "answer-types": {
      "NF1": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "54cf705ff693c3b16b000014",
    "question": "List receptors of the drug Cilengitide",
    "answer-types": {
      "αvβ3 integrin": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "αvβ5": [],
      "αvβ3": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "ανβ5 integrin": []
    },
    "type-counts": {
      "umls:rcpt": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "5171a1498ed59a060a000012",
    "question": "Which genes are more frequently affected by somatic mutations in Chronic Lymphocytic Leukemia",
    "answer-types": {
      "DDX3X": [
        "umls:gngm"
      ],
      "XPO1": [
        "umls:gngm"
      ],
      "NOTCH1": [
        "umls:gngm"
      ],
      "ZMYM3": [
        "umls:gngm"
      ],
      "FBXW7": [
        "umls:bacs",
        "umls:aapp"
      ],
      "KLHL6": [
        "umls:gngm"
      ],
      "MAPK1": [
        "umls:gngm"
      ],
      "ATM": [
        "umls:dsyn"
      ],
      "TP53": [
        "umls:gngm"
      ],
      "SF3B1": [
        "umls:gngm"
      ],
      "MYD88": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1,
      "umls:bacs": 1,
      "umls:gngm": 9,
      "umls:aapp": 1
    }
  },
  {
    "qid": "516be1d6298dcd4e5100006a",
    "question": "What is the mode of inheritance of nemaline myopathy?",
    "answer-types": {
      "autosomal dominant": [
        "umls:genf"
      ],
      "autosomal recessive": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 2
    }
  },
  {
    "qid": "56d860ad51531f7e33000002",
    "question": "Which syndrome is NHE6 associated with?",
    "answer-types": {
      "Christianson syndrome": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "530b01a6970c65fa6b000008",
    "question": "Why is lock mass used in Orbitrap measurements?",
    "answer-types": {
      "The lock mass is a compound of known mass and is used to compensate for drifts in instrument calibration.": []
    },
    "type-counts": {}
  },
  {
    "qid": "52bf1cad03868f1b0600000a",
    "question": "Which virus is Cidofovir (Vistide) indicated for?",
    "answer-types": {
      "cytomegalovirus": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54d77bdf3706e89528000019",
    "question": "List chromosomes that have been linked to Arnold Chiari syndrome in the literature.",
    "answer-types": {
      "22": [
        "umls:bpoc"
      ],
      "12": [
        "umls:qnco"
      ],
      "13": [
        "umls:bpoc"
      ],
      "15": [
        "umls:bpoc"
      ],
      "16": [
        "umls:bpoc"
      ],
      "18": [
        "umls:bpoc"
      ],
      "1": [
        "umls:qnco"
      ],
      "3": [
        "umls:qnco"
      ],
      "5": [
        "umls:bpoc"
      ],
      "6": [
        "umls:bpoc"
      ],
      "8": [
        "umls:qnco"
      ],
      "X": [
        "umls:bpoc"
      ],
      "9": [
        "umls:qnco"
      ],
      "Y": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:bpoc": 8,
      "umls:bacs": 1,
      "umls:phsu": 1,
      "umls:aapp": 1,
      "umls:qnco": 5
    }
  },
  {
    "qid": "552faababc4f83e828000005",
    "question": "Which translocation is the hallmark of Ewing sarcoma?",
    "answer-types": {
      "translocation t(11;22) (q24;12)": [
        "umls:lbpr"
      ]
    },
    "type-counts": {
      "umls:lbpr": 1
    }
  },
  {
    "qid": "56be0a18ef6e394741000006",
    "question": "List symptoms of Meigs\u0027 Syndrome.",
    "answer-types": {
      "ascites": [
        "umls:fndg"
      ],
      "pleural effusion": [
        "umls:dsyn"
      ],
      "benign ovarian tumor": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:neop": 1,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "55390901bc4f83e828000014",
    "question": "What is the effect of CRD-BP on the stability of c-myc mRNA?",
    "answer-types": {
      "To protect c-myc CRD from endonucleolytic attack.": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c341acfedd0b786b000001",
    "question": "What is the molecular function of psoralen photobinding on DNA?",
    "answer-types": {
      "It intercalates into the double helix.": []
    },
    "type-counts": {}
  },
  {
    "qid": "5311b99ae3eabad021000004",
    "question": "Which medical diagnostic tests are used to test kidney function?",
    "answer-types": {
      "eGFR": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "Decreased tryptophan": [
        "umls:topp"
      ],
      "Urine Tests": [
        "umls:lbpr"
      ],
      "Blood Tests": [
        "umls:lbpr"
      ],
      "TRP": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "Kidney Biopsy": [
        "umls:diap"
      ],
      "estimated GFR (eGFR)": [],
      "Decreased tryptophan (TRP)": [
        "umls:topp"
      ],
      "Imaging Tests": [
        "umls:topp"
      ],
      "estimated GFR": []
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:diap": 1,
      "umls:lbpr": 2,
      "umls:topp": 3,
      "umls:rcpt": 1,
      "umls:bacs": 1,
      "umls:phsu": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "53189656b166e2b80600001c",
    "question": "Against which protein is the antibody used for immonostaining of Lewy bodies raised?",
    "answer-types": {
      "alpha-Synuclein": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5131fa145274a5fb07000009",
    "question": "Which are the main causes of fetal echogenic bowel?",
    "answer-types": {
      "CMV infection": [
        "umls:dsyn"
      ],
      "CF": [
        "umls:geoa"
      ],
      "Cystic Fibrosis": [
        "umls:dsyn"
      ],
      "Fetal aneuploidy": [
        "umls:lbpr"
      ],
      "Cystic Fibrosis (CF)": [
        "umls:dsyn"
      ],
      "Itramniotic bleeding": []
    },
    "type-counts": {
      "umls:lbpr": 1,
      "umls:dsyn": 3,
      "umls:geoa": 1
    }
  },
  {
    "qid": "515ddda6298dcd4e5100001f",
    "question": "What is the percentage of responders to tetrabenazine treatment for dystonia in children?",
    "answer-types": {
      "up to \u003e 60%": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "54d6562c3706e8952800000b",
    "question": "Which is the enzymatic activity of the myotubularin family of proteins?",
    "answer-types": {
      "lipid inositol phosphatase activity": []
    },
    "type-counts": {}
  },
  {
    "qid": "56bc7d71ac7ad10019000018",
    "question": "Which disease can be treated with Delamanid?",
    "answer-types": {
      "tuberculosis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "51630226298dcd4e5100004d",
    "question": "What are the advantages of the top down mass spectrometric analysis of histones?",
    "answer-types": {
      "determination of the type and location of post translational modifications": [],
      "isoform characteriztion": []
    },
    "type-counts": {}
  },
  {
    "qid": "56d3346cf22319765a000008",
    "question": "What is situs inversus?",
    "answer-types": {
      "Situs inversus totalis is a rare congenital anomaly with a complete mirror image of the thoracic and abdominal organs.": []
    },
    "type-counts": {}
  },
  {
    "qid": "52b2e1d8f828ad283c00000c",
    "question": "What is the indication of Daonil (Glibenclamide)?",
    "answer-types": {
      "Diabetes mellitus": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "55411d9f379ddf3f47000001",
    "question": "Which is the most typical peptide sequence responsible for retrieval of endoplasmic reticulum (ER) lumenal proteins from the Golgi apparatus?",
    "answer-types": {
      "KDEL": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "the carboxyl-terminal Lys-Asp-Glu-Leu (KDEL)": [],
      "the carboxyl-terminal Lys-Asp-Glu-Leu": []
    },
    "type-counts": {
      "umls:rcpt": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5505eed08e1671127b000006",
    "question": "List the main proteases used for sample digestion in proteomics.",
    "answer-types": {
      "thermolysin": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Asp-N": [
        "umls:enzy",
        "umls:aapp"
      ],
      "LysC": [
        "umls:enzy",
        "umls:aapp"
      ],
      "trypsin": [
        "umls:enzy",
        "umls:aapp",
        "umls:phsu"
      ],
      "chymotrypsin": [
        "umls:enzy",
        "umls:aapp",
        "umls:phsu"
      ],
      "Glu-C": [
        "umls:nnon",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:enzy": 5,
      "umls:phsu": 2,
      "umls:aapp": 6
    }
  },
  {
    "qid": "55451e53bf90a13052000003",
    "question": "Which proteins act as factors that promote transcription-coupled repair in bacteria?",
    "answer-types": {
      "NusA": [
        "umls:euka"
      ],
      "Mfd": [
        "umls:diap"
      ]
    },
    "type-counts": {
      "umls:euka": 1,
      "umls:diap": 1
    }
  },
  {
    "qid": "54d907c84b1fd0d33c000008",
    "question": "Which molecule is targeted by a monoclonal antibody Mepolizumab?",
    "answer-types": {
      "interleukin-5": [
        "umls:imft",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "550342a8f8aee20f27000002",
    "question": "Which is the major symptom of the Doose syndrome?",
    "answer-types": {
      "myoclonic astatic epilepsy": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "52eea509c8da89891000000d",
    "question": "Which genes are affected in ROMANO-WARD syndrome?",
    "answer-types": {
      "KCNH2": [
        "umls:gngm"
      ],
      "KCNJ5": [
        "umls:gngm"
      ],
      "KCNE1": [
        "umls:gngm"
      ],
      "KCNE2": [
        "umls:gngm"
      ],
      "CAV3": [
        "umls:gngm"
      ],
      "Ankyrin-B gene": [],
      "KCNA9": [
        "umls:gngm"
      ],
      "HERG": [
        "umls:gngm"
      ],
      "KCNQ1": [
        "umls:gngm"
      ],
      "KVLQT1": [
        "umls:gngm"
      ],
      "AKAP9": [
        "umls:bacs",
        "umls:aapp"
      ],
      "SCN5A": [
        "umls:gngm"
      ],
      "SCN4B": [
        "umls:gngm"
      ],
      "SNTA1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 12,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56bdc79bef6e394741000001",
    "question": "Which eye condition is managed by the athens protocol?",
    "answer-types": {
      "Keratoconus": [
        "umls:dsyn"
      ],
      "cornea blindness due to severe corneal scarring": []
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54e1252fae9738404b000003",
    "question": "What are the major clinical Villefranche criteria for classic Ehlers-Danlos syndrome?",
    "answer-types": {
      "skin hyperextensibility": [
        "umls:fndg"
      ],
      "dystrophic scarring": [
        "umls:fndg"
      ],
      "joint hypermobility": [
        "umls:patf"
      ]
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:patf": 1
    }
  },
  {
    "qid": "515da6e2298dcd4e51000010",
    "question": "What is the treatment of neuropathic pain in children?",
    "answer-types": {
      "Oxcarbazepine": [
        "umls:orch",
        "umls:phsu"
      ],
      "Opioids alone, in rotations or with Analgesics": [],
      "Ketamine": [
        "umls:orch",
        "umls:phsu"
      ],
      "Opioids and Benzodiazepines - for terminal care": [],
      "e.g. Ketamine and Lidocaine infusion": [],
      "Opioids alone, in rotations or with Analgesics (e.g. Ketamine and Lidocaine infusion)": [],
      "Lidocaine 5% patches for chronic localized neuropathic pain": [],
      "Tricyclic Antidepressants": [
        "umls:phsu"
      ],
      "Pregabalin": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 3,
      "umls:phsu": 4
    }
  },
  {
    "qid": "5118dd1305c10fae75000001",
    "question": "Is Rheumatoid Arthritis more common in men or women?",
    "answer-types": {
      "Women": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "532aad53d6d3ac6a34000010",
    "question": "Is there a crystal structure of the full-length of the flaviviridae NS5(Methyltransferase - RNA depended RNA Polymerase) ?",
    "answer-types": {
      "Japanese encephalitis virus (Flaviviridae) NS5 - PDB:4K6M": [
        "umls:virs"
      ],
      "Japanese encephalitis virus": [
        "umls:virs"
      ],
      "Flaviviridae": [
        "umls:virs"
      ]
    },
    "type-counts": {
      "umls:virs": 3
    }
  },
  {
    "qid": "534ebb59288f4dae47000004",
    "question": "Which methyl-CpG-binding protein when mutant becomes the hallmark for Rett syndrome?",
    "answer-types": {
      "MECP2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Methyl-CpG-binding protein 2 (MECP2)": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Methyl-CpG-binding protein 2": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 3,
      "umls:aapp": 3
    }
  },
  {
    "qid": "517a8bef8ed59a060a000041",
    "question": "Which deiodinases are present in skeletal muscle?",
    "answer-types": {
      "Type 2 deiodinase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Tipe 3 deiodinase": []
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5148885ad24251bc05000032",
    "question": "Which genes are involved in patient response to warfarin?",
    "answer-types": {
      "VKORC1": [
        "umls:gngm"
      ],
      "CYP2C9": [
        "umls:enzy",
        "umls:aapp"
      ],
      "ORM1": [
        "umls:gngm"
      ],
      "PROC": [
        "umls:gngm"
      ],
      "GGCX": [
        "umls:gngm"
      ],
      "CYP4F2": [
        "umls:gngm"
      ],
      "EPHX1": [
        "umls:enzy",
        "umls:aapp"
      ],
      "protein S": [
        "umls:bacs",
        "umls:aapp"
      ],
      "clotting factor V": [
        "umls:imft",
        "umls:aapp"
      ],
      "CYP2C19": [
        "umls:enzy",
        "umls:aapp"
      ],
      "CYP3A5": [
        "umls:gngm"
      ],
      "CYP2C18": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 4,
      "umls:imft": 1,
      "umls:bacs": 1,
      "umls:gngm": 6,
      "umls:aapp": 6
    }
  },
  {
    "qid": "54d7ae1fe19bba8909000001",
    "question": "Which is the molecular weight of the protein angiogenin?",
    "answer-types": {
      "14,120 Da": []
    },
    "type-counts": {}
  },
  {
    "qid": "571e189dbb137a4b0c000003",
    "question": "List sodium glucose co-transporter-2 (SGLT2) inhibitors that have been FDA approved for type 2 diabetes mellitus treatment.",
    "answer-types": {
      "Empagliflozin": [
        "umls:orch",
        "umls:phsu"
      ],
      "Canagliflozin": [
        "umls:orch",
        "umls:phsu"
      ],
      "Dapagliflozin": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 3,
      "umls:phsu": 3
    }
  },
  {
    "qid": "532f55fed6d3ac6a34000036",
    "question": "What is the gene mutated in the Gaucher disease?",
    "answer-types": {
      "glucocerebrosidase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52bf1f4503868f1b06000016",
    "question": "For the treatment of which conditions can atypical neuroleptic drugs be used?",
    "answer-types": {
      "ADHD": [
        "umls:mobd"
      ],
      "attention deficit hyperactivity disorder": [
        "umls:mobd"
      ],
      "attention deficit hyperactivity disorder (ADHD) with negativism or conduct disorders": [
        "umls:mobd"
      ],
      "delusional disorder": [
        "umls:mobd"
      ],
      "schizophrenia psychosis": [
        "umls:mobd"
      ],
      "schizophrenia": [
        "umls:mobd"
      ],
      "psychotic disorders": [
        "umls:mobd"
      ],
      "psychotic relapse in neuroleptic malignant syndrome": [],
      "schizoaffective disorder": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:mobd": 8
    }
  },
  {
    "qid": "52eeddfcc8da898910000010",
    "question": "Which are the characteristics of Andersen syndrome?",
    "answer-types": {
      "ventricular arrhythmia": [
        "umls:dsyn"
      ],
      "skeletal dysmorphisms": [],
      "periodic paralysis": [
        "umls:dsyn"
      ],
      "abnormal QT-U complex": [],
      "facial dysmorphisms": [
        "umls:cgab"
      ]
    },
    "type-counts": {
      "umls:cgab": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "5519110f622b19434500000c",
    "question": "Which disease is included as an additional feature in the Goldberg-Shprintzen syndrome?",
    "answer-types": {
      "Craniosynostosis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54ff45966ad7dcbc12000010",
    "question": "Which protein is causing Netherton syndrome?",
    "answer-types": {
      "LEKTI": [
        "umls:gngm"
      ],
      "lymphoepithelial Kazal type-related inhibitor": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 2
    }
  },
  {
    "qid": "56f56a8609dd18d46b00000b",
    "question": "Mutations in which gene and which protein are associated with Netherton syndrome?",
    "answer-types": {
      "LEKTI protein": [
        "umls:aapp"
      ],
      "SPINK5 gene": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "550c3754a103b78016000007",
    "question": "Which disease of the central nervous system is characterized by the presence of Lewy bodies?",
    "answer-types": {
      "Parkinson\u0027s disease": [
        "umls:dsyn"
      ],
      "PD": [
        "umls:elii"
      ],
      "Parkinson\u0027s disease (PD)": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:elii": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "517a8b768ed59a060a00003f",
    "question": "Which deiodinase is known to be present in liver?",
    "answer-types": {
      "Type 1 deiodinase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "type 3 deiodinase": []
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52fa6ac72059c6d71c000055",
    "question": "Is the transcriptional regulator BACH1 an activator or a repressor?",
    "answer-types": {
      "Repressor": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "54fb6fb5d176fff445000004",
    "question": "Which proteins participate in the formation of the Notch transcriptional activation complex?",
    "answer-types": {
      "Suppressor of Hairless": [
        "umls:bacs",
        "umls:aapp"
      ],
      "NIC": [
        "umls:geoa"
      ],
      "MAML-1": [],
      "Lag-1": [
        "umls:imft",
        "umls:aapp"
      ],
      "The coactivator protein Mastermind-like 1": [
        "umls:aapp"
      ],
      "Intracellular part of Notch": [],
      "Notch intracellular domain (NICD)": [
        "umls:aapp"
      ],
      "CBF1": [
        "umls:gngm"
      ],
      "ICN": [
        "umls:pros"
      ],
      "RBP-Jkappa": [
        "umls:bacs",
        "umls:aapp"
      ],
      "NICD": [
        "umls:aapp"
      ],
      "Transcription factor CSL": [
        "umls:celc"
      ],
      "Notch intracellular domain": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:celc": 1,
      "umls:pros": 1,
      "umls:imft": 1,
      "umls:geoa": 1,
      "umls:gngm": 1,
      "umls:bacs": 2,
      "umls:aapp": 7
    }
  },
  {
    "qid": "56c1f003ef6e394741000039",
    "question": "What molecule is targeted by suvorexant?",
    "answer-types": {
      "orexin": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "571e14fbbb137a4b0c000001",
    "question": "For which type of diabetes can empagliflozin be used?",
    "answer-types": {
      "type 2 diabetes mellitus": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "532c0c21d6d3ac6a3400001b",
    "question": "Which are the main methods for pharmacophore modelling?",
    "answer-types": {
      "Ligand-based, pharmacophore modeling": [],
      "Structure-base, pharmacophore modeling": []
    },
    "type-counts": {}
  },
  {
    "qid": "52f77f4d2059c6d71c00002a",
    "question": "Which are the enzymes involved in the addition of 7-methylguanosine in mRNA?",
    "answer-types": {
      "RNA guanine-7 methyltransferase": [
        "umls:gngm"
      ],
      "RNA guanylyltransferase and 5\u0027-phosphatase": [
        "umls:gngm"
      ],
      "RNA polymerase II": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:gngm": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "57136a7e1174fb1755000006",
    "question": "How early during pregnancy does non-invasive cffDNA testing allow sex determination of the fetus?",
    "answer-types": {
      "first trimester of pregnancy": [
        "umls:tmco"
      ],
      "6th to 10th week of gestation": []
    },
    "type-counts": {
      "umls:tmco": 1
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  },
  {
    "qid": "5166f41a298dcd4e5100005b",
    "question": "Which are the inhibitors of histone methyltransferases?",
    "answer-types": {
      "Psammaplin A": [
        "umls:orch",
        "umls:phsu"
      ],
      "3-deazaneplanocin A": [
        "umls:nnon",
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      ],
      "TSA": [
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      ],
      "BIX-01294": [
        "umls:orch"
      ],
      "Sulforaphane": [
        "umls:orch",
        "umls:phsu"
      ],
      "TM2-115": [],
      "Trichostatin A": [
        "umls:antb",
        "umls:orch"
      ],
      "SFN": [
        "umls:enzy",
        "umls:irda",
        "umls:aapp"
      ],
      "DZNep": [],
      "2,4-pyridinedicarboxylic acid": [
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      ],
      "2,4-PDCA": [
        "umls:orch"
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      "PsA": [
        "umls:enzy",
        "umls:imft",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
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      "umls:orch": 6,
      "umls:imft": 1,
      "umls:aapp": 2,
      "umls:phsu": 3
    }
  },
  {
    "qid": "52efc016c8da89891000001a",
    "question": "What is the life expectancy of professional athletes in respect to the general population?",
    "answer-types": {
      "longer than the general population": []
    },
    "type-counts": {}
  },
  {
    "qid": "517539af8ed59a060a000026",
    "question": "Which genes are regulated by MEF-2 in the heart?",
    "answer-types": {
      "estrogen receptor (ER)alpha gene": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "calsequestrin gene": [
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      "phosphoglycerate mutase": [
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        "umls:aapp"
      ],
      "COX-2": [
        "umls:enzy",
        "umls:aapp"
      ],
      "estrogen receptor": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "cTnC": [],
      "PGAM-M": [
        "umls:gngm"
      ],
      "MLC-2": [],
      "alpha-cardiac myosin heavy chain gene": [
        "umls:lbpr"
      ],
      "sarco(endo)plasmic reticulum Ca2+-ATPase": [
        "umls:moft"
      ],
      "SERCA": [
        "umls:dsyn"
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      "ER": [
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      "MCK": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "cardiac troponin C": [
        "umls:gngm"
      ],
      "casq2": [
        "umls:gngm"
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      "ANF": [
        "umls:imft",
        "umls:aapp"
      ],
      "cTnT": [
        "umls:gngm"
      ],
      "alpha-cardiac actin": [
        "umls:bacs",
        "umls:aapp"
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    "type-counts": {
      "umls:fndg": 1,
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      "umls:moft": 1,
      "umls:enzy": 3,
      "umls:imft": 1,
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      "umls:lbpr": 1,
      "umls:rcpt": 3,
      "umls:bacs": 1,
      "umls:gngm": 4,
      "umls:aapp": 7
    }
  },
  {
    "qid": "53357193d6d3ac6a34000047",
    "question": "Which JAK (Janus kinase) inhibitor is approved for treatment of rheumatoid arthritis?",
    "answer-types": {
      "tofacitinib": [
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        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
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    }
  },
  {
    "qid": "52d2818403868f1b06000033",
    "question": "Which are the newly identified DNA nucleases that can be used to treat thalassemia?",
    "answer-types": {
      "Crispr/CAS": [
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      ],
      "zinc-finger nucleases": [
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        "umls:aapp"
      ],
      "TALEN": [
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        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:orgf": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "571e2beabb137a4b0c000006",
    "question": "How is OCT3 associated with serotonin?",
    "answer-types": {
      "serotonin clearance": []
    },
    "type-counts": {}
  },
  {
    "qid": "5708a845cf1c32585100000f",
    "question": "Which signaling pathway is activating the dishevelled proteins?",
    "answer-types": {
      "Wnt signaling": [
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      ]
    },
    "type-counts": {
      "umls:moft": 1
    }
  },
  {
    "qid": "51405cd123fec90375000005",
    "question": "Which is the defective protein causing the lysosomal storage disease Fabry?",
    "answer-types": {
      "alpha-galactosidase A": [
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        "umls:aapp",
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      "umls:aapp": 1
    }
  },
  {
    "qid": "571cd9537de986d80d00000e",
    "question": "List inflammatory caspase proteins?",
    "answer-types": {
      "caspase-5": [
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      ],
      "caspase-1": [
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      "caspase-4": [
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      "umls:enzy": 3,
      "umls:aapp": 3
    }
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  {
    "qid": "553c994af32186855800000b",
    "question": "List invertebrates where ultraconserved elements have been identified.",
    "answer-types": {
      "worm": [
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      ],
      "diptera": [
        "umls:euka"
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      "yeast": [
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      ],
      "tunicates": [
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      ]
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      "umls:euka": 2,
      "umls:fngs": 1,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "5503133ae9bde6963400001d",
    "question": "Which gene is most commonly associated with severe congenital and cyclic neutropenia?",
    "answer-types": {
      "The neutrophil elastase gene": [
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      ],
      "The neutrophil elastase gene (ELANE)": [
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      ],
      "ELANE": [
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    "type-counts": {
      "umls:gngm": 3
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  },
  {
    "qid": "54e061ee1388e8454a00000c",
    "question": "List two chemotherapeutic agents that are used for treatment of Subependymal Giant Cell Astrocytoma",
    "answer-types": {
      "everolimus": [
        "umls:orch",
        "umls:phsu"
      ],
      "rapamycin": [
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        "umls:orch"
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    },
    "type-counts": {
      "umls:antb": 1,
      "umls:orch": 2,
      "umls:phsu": 1
    }
  },
  {
    "qid": "553d061cf321868558000013",
    "question": "List available databases containing information about conserved noncoding elements.",
    "answer-types": {
      "TFCONES": [],
      "Ancora": [
        "umls:euka"
      ]
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    "type-counts": {
      "umls:euka": 1
    }
  },
  {
    "qid": "569e731cca240fa209000003",
    "question": "What was the purpose of the FANTOM5 project?",
    "answer-types": {
      "To provide comprehensive expression profiles and functional annotation of mammalian cell-type-specific transcriptomes with wide applications in biomedical research.": []
    },
    "type-counts": {}
  },
  {
    "qid": "52b2e409f828ad283c00000e",
    "question": "What disease in Loxapine prominently used for?",
    "answer-types": {
      "schizophrenia": [
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      ]
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    "type-counts": {
      "umls:mobd": 1
    }
  },
  {
    "qid": "56c1f040ef6e394741000055",
    "question": "Which antibodies cause Riedel thyroiditis?",
    "answer-types": {
      "IgG4": [
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      ]
    },
    "type-counts": {
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    }
  },
  {
    "qid": "5179602c8ed59a060a00003d",
    "question": "What are the effects of ILK ablation?",
    "answer-types": {
      "Ablation of ILK in liver results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration and in abnormal histology": [],
      "Ablation of ILK in podocytes caused an aberrant distribution of nephrin and alpha-actinin-4": [],
      "Ablation of ILK in fibroblasts leads to impaired healing due to a severe reduction in the number of myofibroblasts": [],
      "Ablation of ILK in osteoclasts inhibits bone resorption": [],
      "Ablation of ILK in heart results in dilated cardiomyopathy and spontaneous heart failure": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c1f043ef6e394741000057",
    "question": "Which receptors are bound by Tasimelteon?",
    "answer-types": {
      "MT2": [
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      ],
      "MT1": [
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      "umls:aapp": 1
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  },
  {
    "qid": "56f24fec2ac5ed1459000015",
    "question": "Which RNA polymerase is used for the replication of viroids?",
    "answer-types": {
      "RNAP II": [
        "umls:enzy",
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      ],
      "DNA-dependent RNA polymerase II": [
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      "RNA polymerase II": [
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    }
  },
  {
    "qid": "5318380bb166e2b806000013",
    "question": "List Parkin binding partners",
    "answer-types": {
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        "umls:rcpt",
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      ],
      "HSP90": [
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      "HSP60": [
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        "umls:aapp"
      ],
      "CDC37": [
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      "PICK1": [
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      "XAPC7": [
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      "GRP75": [
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      "PSMA7": [
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      "LRPPRC": [
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      "TUFM": [
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      "umls:gngm": 6,
      "umls:bacs": 2,
      "umls:aapp": 4
    }
  },
  {
    "qid": "56f146db2ac5ed145900000f",
    "question": "Is single guide RNA part of the CRISPR/Cas9 tool or an inhibitor of its function?",
    "answer-types": {
      "Single guide RNA is part of the CRISPR/Cas9 system.": [
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      ]
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  {
    "qid": "54e1bdacae9738404b000009",
    "question": "What is generic name of drug Adempas?",
    "answer-types": {
      "riociguat": [
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  },
  {
    "qid": "5321bc309b2d7acc7e00000d",
    "question": "What is the target protein of the drug Idelalisib?",
    "answer-types": {
      "PI3K-δ": [
        "umls:gngm"
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      "phosphoinositol-3 kinase delta isoform": []
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "51588bb2d24251bc05000091",
    "question": "Which antiepileptic drug is most strongly associated with spina bifida?",
    "answer-types": {
      "Valproate": [
        "umls:orch",
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      ]
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    "type-counts": {
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    }
  },
  {
    "qid": "571cdd227de986d80d00000f",
    "question": "Which bacteria caused plague?",
    "answer-types": {
      "Yersinia pestis": [
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    "type-counts": {
      "umls:bact": 1
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  },
  {
    "qid": "53440d2caeec6fbd07000004",
    "question": "Is the long non- coding RNA malat-1 up or downregulated in cancer?",
    "answer-types": {
      "upregulated": [
        "_CHOICE"
      ]
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    "type-counts": {
      "_CHOICE": 1
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  },
  {
    "qid": "54f9b74306d9727f76000004",
    "question": "The drug JTV519 is derivative of which group of chemical compounds?",
    "answer-types": {
      "1,4-benzothiazepine": [
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      ],
      "benzothiazepine": [
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    "type-counts": {
      "umls:orch": 2
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  },
  {
    "qid": "530c7f52970c65fa6b000010",
    "question": "Oxantel is used for periodontitis treatment. How does it work?",
    "answer-types": {
      "Oxantel disrupts polymicrobial biofilm": []
    },
    "type-counts": {}
  },
  {
    "qid": "56e6dfc2edfc094c1f000003",
    "question": "What is apelin?",
    "answer-types": {
      "Apelin, a small regulatory peptide, is the endogenous ligand for the apelin receptor (APJ) receptor.": [],
      "Apelin, a small regulatory peptide, is the endogenous ligand for the apelin receptor": [],
      "APJ": [
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      ]
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    "type-counts": {
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  },
  {
    "qid": "531d744c267d7dd053000009",
    "question": "What is the function of the protein encoded by the gene PABPC4?",
    "answer-types": {
      "PABC4 is important for mRNA stability and translation initiation, in chronic inflammation and in the pathogenesis of colorectal cancer.": []
    },
    "type-counts": {}
  },
  {
    "qid": "55241f9e2c8b63434a000004",
    "question": "What kind of enzyme is encoded by the proto-oncogene ABL1?",
    "answer-types": {
      "Nonreceptor tyrosine kinase": [
        "umls:gngm"
      ],
      "Protein-Tyrosine Kinase": [
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      "umls:aapp": 1
    }
  },
  {
    "qid": "52ee9f55c8da898910000009",
    "question": "What is the mode of inheritance of Romano Ward long QT syndrome?",
    "answer-types": {
      "autosomal dominant": [
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    "type-counts": {
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  {
    "qid": "52e92c6e98d0239505000024",
    "question": "Which gene is associated with the Mitchell-Riley syndrome?",
    "answer-types": {
      "RFX6": [
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    "type-counts": {
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  {
    "qid": "5324cca79b2d7acc7e00001d",
    "question": "What are the mobile applications fields of use for patients ?",
    "answer-types": {
      "fluid intake": [
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      ],
      "dermatology": [
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      "urine flow": [
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      "fitness": [
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      "weight loss": [
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      "exercise": [
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      "physical activity": [
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      "alcohol-use behavior change": []
    },
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      "umls:phsf": 1,
      "umls:bmod": 1
    }
  },
  {
    "qid": "54f431d664850a5854000006",
    "question": "Which are the genes responsible for Dyskeratosis Congenita?",
    "answer-types": {
      "TERT": [
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      "TERC": [
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      "DKC1": [
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      "NHP2": [
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      "C16orf57": [
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      "TIN2": [
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      "NOP10": [
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      "TCAB1": [
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      "umls:gngm": 6,
      "umls:bacs": 1,
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  },
  {
    "qid": "5354f289288f4dae47000008",
    "question": "Name five programs for transcript quantification from RNASeq experiments",
    "answer-types": {
      "Pome": [
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      "IsoformEx": [],
      "Tigar": [
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      "Flux Capacitor": [],
      "Cufflinks": [],
      "Neuma": [],
      "Montebello": [],
      "Mitie": [],
      "Miso": [
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      ],
      "Drut": [],
      "Traph": [],
      "RSEM": []
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    "type-counts": {
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      "umls:food": 1
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  },
  {
    "qid": "550c3d45a103b78016000008",
    "question": "What is the main component of the Lewy bodies?",
    "answer-types": {
      "Alpha-synuclein": [
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  },
  {
    "qid": "56ae2fab0a360a5e45000006",
    "question": "What is the link between HOT regions and RNA polymerase recruitment?",
    "answer-types": {
      "Transcription-factor occupancy at HOT regions quantitatively predicts RNA polymerase recruitment.": []
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  {
    "qid": "570a5343cf1c325851000022",
    "question": "List variants of the MC1R gene.",
    "answer-types": {
      "R151C": [],
      "R160W": [],
      "V92M": [],
      "D84E": [],
      "D294H": [],
      "V60L": [],
      "R163Q": []
    },
    "type-counts": {}
  },
  {
    "qid": "56cdf5315795f9a73e000046",
    "question": "Which is the enzyme that degrades decapped mRNAs?",
    "answer-types": {
      "XRN1": [
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    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "5713b29f1174fb175500000f",
    "question": "Which phenotypes are associated with heterozygous mutations of the BSCL2 gene?",
    "answer-types": {
      "Silver syndrome/spastic paraplegia 17": [],
      "CMT2": [
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      ],
      "Charcot-Marie-Tooth disease type 2 (CMT2) with predominant hand involvement": [
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      ],
      "Charcot-Marie-Tooth disease type 2": [
        "umls:dsyn"
      ],
      "Distal hereditary motor neuropathy type V": [
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      ]
    },
    "type-counts": {
      "umls:dsyn": 3,
      "umls:gngm": 1
    }
  },
  {
    "qid": "56f780cb09dd18d46b000011",
    "question": "Which is the target protein of the drug nivolumab?",
    "answer-types": {
      "programmed death receptor-1": [
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        "umls:rcpt",
        "umls:aapp"
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    },
    "type-counts": {
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      "umls:aapp": 1
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  },
  {
    "qid": "5141bcd423fec9037500000d",
    "question": "The CXCR2 receptor is targeted in cancer. Name five antagonists.",
    "answer-types": {
      "AZ10397767": [],
      "SCH-479833": [
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      "SB225002": [
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      "G31P": [
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      ],
      "SCH-527123": [
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      ]
    },
    "type-counts": {
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      "umls:aapp": 1
    }
  },
  {
    "qid": "5717dbfe7de986d80d000001",
    "question": "What is the functional role of the protein Drp1?",
    "answer-types": {
      "mitochondrial fission": [
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    "type-counts": {
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  },
  {
    "qid": "52bf1af803868f1b06000008",
    "question": "Which diseases are caused by mutations in Calsequestrin 2 (CASQ2) gene?",
    "answer-types": {
      "catecholaminergic polymorphic ventricular tachycardia": [
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      ],
      "catecholaminergic polymorphic ventricular tachycardia (CPVT)": [
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      "CPVT": [
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      "familial hypertrophic cardiomyopathy": [
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    },
    "type-counts": {
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      "umls:dsyn": 3
    }
  },
  {
    "qid": "56cf20eb3975bb303a000001",
    "question": "What does isradipine do to L-type channels?",
    "answer-types": {
      "blocks": [
        "umls:patf"
      ],
      "antagonizes": []
    },
    "type-counts": {
      "umls:patf": 1
    }
  },
  {
    "qid": "550303a5e9bde6963400000c",
    "question": "In which diseases have electronic patient diaries been applied ?",
    "answer-types": {
      "Chronic Obstructive Airways Disease": [
        "umls:dsyn"
      ],
      "Allergy": [
        "umls:bmod"
      ],
      "Headache": [
        "umls:sosy"
      ],
      "Parkinson\u0027s disease": [
        "umls:dsyn"
      ],
      "Migraine": [
        "umls:dsyn"
      ],
      "Migraine Disorder": [
        "umls:dsyn"
      ],
      "Migraine Headaches": [
        "umls:dsyn"
      ],
      "Niacin induced flushing": [],
      "Reflux": [
        "umls:patf"
      ],
      "Chronic  obstructive pulmonary disease": [
        "umls:dsyn"
      ],
      "GERD": [
        "umls:dsyn"
      ],
      "Esophageal reflux": [
        "umls:dsyn"
      ],
      "Chronic Obstructive Lung Disease": [
        "umls:dsyn"
      ],
      "Hemophilia": [
        "umls:dsyn"
      ],
      "Food hypersensitivity": [
        "umls:patf"
      ],
      "Heartburn": [
        "umls:sosy"
      ],
      "COPD": [
        "umls:dsyn"
      ],
      "migraine headache": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:sosy": 2,
      "umls:patf": 2,
      "umls:dsyn": 12,
      "umls:bmod": 1
    }
  },
  {
    "qid": "56ed0ffe2ac5ed1459000008",
    "question": "Which type of myeloma is ixazomib being evaluated for?",
    "answer-types": {
      "Multiple myeloma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "51bdf045047fa84d1d000003",
    "question": "Which are the Atg8 homologs in human?",
    "answer-types": {
      "GEC-1": [
        "umls:orch"
      ],
      "LC3C": [
        "umls:gngm"
      ],
      "LC3B": [
        "umls:gngm"
      ],
      "Ganglioside expression factor 2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "GEF-2": [
        "umls:gngm"
      ],
      "LC3A": [
        "umls:gngm"
      ],
      "MM46": [
        "umls:gngm"
      ],
      "General protein transport factor p16": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Early estrogen-regulated protein": [],
      "GABARAP": [
        "umls:gngm"
      ],
      "GABA(A) receptor-associated protein-like 2": [
        "umls:gngm"
      ],
      "GABA(A) receptor-associated protein-like 1": [
        "umls:gngm"
      ],
      "MAP1LC3B": [
        "umls:gngm"
      ],
      "MAP1LC3A": [
        "umls:gngm"
      ],
      "MAP1LC3C": [
        "umls:gngm"
      ],
      "GABARAPL2": [
        "umls:gngm"
      ],
      "GATE-16": [
        "umls:gngm"
      ],
      "GABARAPL1": [
        "umls:gngm"
      ],
      "microtubule-associated protein-1 light chain 3A": [],
      "microtubule-associated protein-1 light chain 3B": [
        "umls:aapp"
      ],
      "GABA(A) receptor-associated protein": [
        "umls:gngm"
      ],
      "Gamma-aminobutyric acid receptor-associated protein": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Golgi-associated ATPase enhancer of 16 kDa": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Glandular epithelial cell protein 1": [
        "umls:gngm"
      ],
      "MAP1 light chain 3-related protein": [
        "umls:bacs",
        "umls:aapp"
      ],
      "microtubule-associated protein-1 light chain 3C": [],
      "Gamma-aminobutyric acid receptor-associated protein-like 1": [],
      "Gamma-aminobutyric acid receptor-associated protein-like 2": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:bacs": 6,
      "umls:gngm": 16,
      "umls:aapp": 7
    }
  },
  {
    "qid": "56b76d916e3f8eaf4c000001",
    "question": "To which family does the Zika virus belong?",
    "answer-types": {
      "Flaviviridae": [
        "umls:virs"
      ]
    },
    "type-counts": {
      "umls:virs": 1
    }
  },
  {
    "qid": "5177def18ed59a060a000034",
    "question": "Which is the molecular mechanism underlying K-ras alterations in carcinomas?",
    "answer-types": {
      "Point mutations": [
        "umls:comd"
      ]
    },
    "type-counts": {
      "umls:comd": 1
    }
  },
  {
    "qid": "515db020298dcd4e51000011",
    "question": "List all clinical trials of the polypill.",
    "answer-types": {
      "Second Indian Polycap Study, TIPS-2": [],
      "Use of a Multidrug Pill In Reducing cardiovascular Events\u0027": [],
      "IMProving Adherence using Combination Therapy": [],
      "Kanyini-GAP": [],
      "GEMINI trial, 14-week\\, open-label trial conducted in 1220 patients from the USA": [],
      "Use of a Multidrug Pill In Reducing cardiovascular Events\u0027 (UMPIRE) trial, European Clinical Trials database\\, as EudraCT: 2009-016278-34 and the Clinical Trials Registry\\, India as CTRI/2010/091/000250.": [],
      "Cluster Randomized Usual Care vs Caduet Investigation Assessing Long-term-risk (CRUCIAL trial)": [],
      "ndian Polycap Study, TIPS": [],
      "CUSP": [
        "umls:blor"
      ],
      "IMProving Adherence using Combination Therapy (IMPACT)\u0027, Australian New Zealand Clinical Trial Registry (ACTRN12606000067572)": [],
      "IMPACT)\u0027, Australian New Zealand Clinical Trial Registry (ACTRN12606000067572": [],
      "The Caduet® in an Untreated Subject Population trial": [],
      "Kanyini Guidelines Adherence with the Polypill": [],
      "Cluster Randomized Usual Care vs Caduet Investigation Assessing Long-term-risk": [],
      "CRUCIAL trial": [],
      "CUSP (The Caduet® in an Untreated Subject Population trial)": [
        "umls:blor"
      ],
      "JEWEL 2 conducted in 1107 patients from Europe": [],
      "Phase II study of the Polycap, double-blind\\, randomised trial\\, registered with ClinicalTrials.gov\\, number NCT00443794": [],
      "A randomised controlled trial in seven countries – Australia, Brazil\\, India\\, Netherlands\\, New Zealand\\, United Kingdom and United States\\, Australian New Zealand Clinical Trials Registry": [],
      "TOGETHER trial": [],
      "UMPIRE": [],
      "JEWEL 1 conducted among 1138 patients from the UK and Canada": [],
      "A randomised controlled trial in seven countries – Australia, Brazil\\, India\\, Netherlands\\, New Zealand\\, United Kingdom and United States\\, Australian New Zealand Clinical Trials Registry (ACTRN 12607000099426)": [],
      "CAPABLE54, the Clinical Utility of Caduet in Simultaneously Achieving Blood Pressure and Lipid End Points\\, in the USA": [],
      "ACTRN 12607000099426": [],
      "Kanyini Guidelines Adherence with the Polypill (Kanyini-GAP)": [],
      "GEMINI-Australia, Asia\\, Latin America\\, Africa/Middle East (AALA) study": []
    },
    "type-counts": {
      "umls:blor": 2
    }
  },
  {
    "qid": "56f4011709dd18d46b000003",
    "question": "What is the main symptom of Marfan syndrome patients?",
    "answer-types": {
      "aortic root dissection": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "51635202298dcd4e5100004f",
    "question": "How is myotonic dystrophy inherited?",
    "answer-types": {
      "autosomal dominant": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "553f72edab98a37113000007",
    "question": "What is the typical outer diameter of microtubules (tubulin heterodimers)?",
    "answer-types": {
      "24nm - 25 nm": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "533c2a55c45e133714000003",
    "question": "Which are the mammalian orthologs of Drosophila Yki?",
    "answer-types": {
      "YAP": [
        "umls:gngm"
      ],
      "TAZ": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 1,
      "umls:gngm": 1
    }
  },
  {
    "qid": "5506ce078e1671127b00000b",
    "question": "Which protein phosphatase has been found to interact with the heat shock protein, HSP20?",
    "answer-types": {
      "PP1": [
        "umls:imft",
        "umls:aapp"
      ],
      "Protein phosphatase 1": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:imft": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "54fc99f36ad7dcbc12000004",
    "question": "Neurostimulation of which nucleus is used for treatment of dystonia?",
    "answer-types": {
      "globus pallidus internus": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 1
    }
  },
  {
    "qid": "5548da00f35db7552600000b",
    "question": "Which myosin isozymes are located within the pericuticular necklace of the hair cell?",
    "answer-types": {
      "myosin-VI": [
        "umls:aapp"
      ],
      "myosin-VIIa": [
        "umls:aapp"
      ],
      "myosins-Ibeta": []
    },
    "type-counts": {
      "umls:aapp": 2
    }
  },
  {
    "qid": "530db83b38c1322806000002",
    "question": "Which proteins cause cytoplasmic sequestration of NF-kB?",
    "answer-types": {
      "I-kBs": [],
      "p100": [
        "umls:bacs",
        "umls:aapp"
      ],
      "NF-kB2 (p100)": [
        "umls:gngm"
      ],
      "Sef": [
        "umls:gngm"
      ],
      "p105": [
        "umls:gngm"
      ],
      "NF-kB1 (p105)": [
        "umls:gngm"
      ],
      "NF-kB2": [
        "umls:gngm"
      ],
      "NF-kB1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 6,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "532f0bd6d6d3ac6a3400002d",
    "question": "What is the mode of inheritance of Marchesani syndrome?",
    "answer-types": {
      "autosomal dominant or autosomal recessive": [
        "umls:fndg"
      ]
    },
    "type-counts": {
      "umls:fndg": 1
    }
  },
  {
    "qid": "56c1f007ef6e39474100003b",
    "question": "Tumor-treating fields are effective for treatment of which cancers?",
    "answer-types": {
      "non-small cell lung cancer": [
        "umls:neop"
      ],
      "glioblastoma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 2
    }
  },
  {
    "qid": "56e46ad951531f7e3300001a",
    "question": "List angiocrine factors",
    "answer-types": {
      "neurotensin": [
        "umls:horm",
        "umls:aapp"
      ],
      "metalloproteinases-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "thrombospondin 3": [
        "umls:aapp"
      ],
      "vascular endothelial growth factor": [
        "umls:bacs",
        "umls:aapp"
      ],
      "hepatocyte growth factor": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Ccl4": [
        "umls:hops",
        "umls:orch"
      ],
      "Slit2": [
        "umls:gngm"
      ],
      "Wnt2": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:hops": 1,
      "umls:orch": 1,
      "umls:horm": 1,
      "umls:gngm": 1,
      "umls:bacs": 4,
      "umls:aapp": 6
    }
  },
  {
    "qid": "571e4293bb137a4b0c00000b",
    "question": "What is the cause of episodic ataxia type 6?",
    "answer-types": {
      "EAAT1 mutations": []
    },
    "type-counts": {}
  },
  {
    "qid": "530cf22aa177c6630c000004",
    "question": "What is the main role of Ctf4 in dna replication?",
    "answer-types": {
      "Coordination of the progression of helicase and DNA polymerase alpha at the eukaryotic replication fork.": []
    },
    "type-counts": {}
  },
  {
    "qid": "53130a77e3eabad02100000f",
    "question": "Which hormone deficiency is implicated in the Costello syndrome ?",
    "answer-types": {
      "Growth hormone": [
        "umls:horm",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:horm": 1,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "530cf22aa177c6630c000005",
    "question": "List the components of a Replisome Progression Complex (RPC).",
    "answer-types": {
      "Mrc1": [
        "umls:gngm"
      ],
      "Cdc45": [
        "umls:bacs",
        "umls:aapp"
      ],
      "FACT": [
        "umls:gngm"
      ],
      "Ctf4": [
        "umls:gngm"
      ],
      "Tof1-Csm3 complex": []
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 3,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56c5feb75795f9a73e000006",
    "question": "Which is the most common CFTR mutation in Caucasians?",
    "answer-types": {
      "deltaF508": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:aapp": 1
    }
  },
  {
    "qid": "56bf487def6e394741000011",
    "question": "Which CDK targets control cytokinesis?",
    "answer-types": {
      "Aip1": [
        "umls:gngm"
      ],
      "Inn1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Ede1": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 2,
      "umls:gngm": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "5543a1b2ee40ea110c000001",
    "question": "In what type(s) of plant organelles we can detect prolamellar bodies?",
    "answer-types": {
      "chloroplasts (in young developing leaves during the night)": [
        "umls:celc"
      ],
      "in young developing leaves during the night": [],
      "chloroplasts": [
        "umls:celc"
      ],
      "etioplasts": [
        "umls:celc"
      ],
      "etioplasts (mainly)": [
        "umls:celc"
      ],
      "mainly": [
        "umls:fndg"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:celc": 4
    }
  },
  {
    "qid": "56cf2be73975bb303a000005",
    "question": "What do mepolizumab and reslizumab have in common?",
    "answer-types": {
      "neutralize interleukin 5": [],
      "treatment for eosinophilic disease": [],
      "treatment for refractory asthma": [],
      "reduce eosinophil counts": [],
      "monoclonal antibodies": [
        "umls:imft",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54d669003706e8952800000e",
    "question": "When are itaconic acid levels elevated?",
    "answer-types": {
      "Immune Defence": []
    },
    "type-counts": {}
  },
  {
    "qid": "5713bc991174fb1755000010",
    "question": "Which genes are associated with autosomal dominant Charcot-Marie-Tooth?",
    "answer-types": {
      "YARS": [
        "umls:enzy",
        "umls:aapp"
      ],
      "EGR2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "LRSAM1": [
        "umls:gngm"
      ],
      "LITAF": [
        "umls:gngm"
      ],
      "GDAP1": [
        "umls:gngm"
      ],
      "DNM2": [
        "umls:gngm"
      ],
      "INF2": [
        "umls:gngm"
      ],
      "GJB1": [
        "umls:gngm"
      ],
      "MPZ": [
        "umls:gngm"
      ],
      "PMP22": [
        "umls:gngm"
      ],
      "GNB4": [
        "umls:gngm"
      ],
      "MFN2": [
        "umls:gngm"
      ],
      "NEFL": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:gngm": 11,
      "umls:bacs": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "54fb4b34d176fff445000001",
    "question": "Which transcription factors (TFs) participate in the formation of the interferon-beta (IFN-b) enhanceosome?",
    "answer-types": {
      "c-jun": [
        "umls:gngm"
      ],
      "NF-kappa B": [
        "umls:imft",
        "umls:aapp"
      ],
      "ATF-2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "NF-kappa B (p50/p65)": [
        "umls:imft",
        "umls:aapp"
      ],
      "IRF-3": [
        "umls:bacs",
        "umls:aapp"
      ],
      "IRF-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "IRF-7": [
        "umls:bacs",
        "umls:aapp"
      ],
      "p50/p65": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1,
      "umls:imft": 2,
      "umls:bacs": 4,
      "umls:gngm": 1,
      "umls:aapp": 6
    }
  },
  {
    "qid": "56a39a32496b62f23f000005",
    "question": "List packages for transcription factor binding sites\u0027 (TFBS) analysis available in R/Bioconductor",
    "answer-types": {
      "Neighbourhood Consistent PC (NCPC) algorithms": [],
      "TFBS": [
        "umls:bpoc"
      ],
      "MMDiff": [],
      "dPattern": [],
      "NCPC": [
        "umls:bact"
      ],
      "Neighbourhood Consistent PC": [],
      "cosmo": [
        "umls:plnt"
      ]
    },
    "type-counts": {
      "umls:plnt": 1,
      "umls:bpoc": 1,
      "umls:bact": 1
    }
  },
  {
    "qid": "56c1f010ef6e394741000041",
    "question": "Simpson grading is used to describe resection of which brain tumor?",
    "answer-types": {
      "meningioma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "51596a8ad24251bc0500009e",
    "question": "Where in the cell do we find the protein Cep135?",
    "answer-types": {
      "centrosome": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "56c1f00def6e39474100003f",
    "question": "Which enzyme is inhibited by Varespladib?",
    "answer-types": {
      "secretory phospholipase A2": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "571e12097de986d80d000017",
    "question": "Which protein does empagliflozin inhibit?",
    "answer-types": {
      "SGLT2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "515de993298dcd4e51000024",
    "question": "List all reported treatment options for anxiety in autism spectrum disorder.",
    "answer-types": {
      "Family cognitive-behavioral therapy": [],
      "Individual cognitive-behavioral therapy": [],
      "Mindfulness Based Therapy": [],
      "even when conflict and family distress is low": [],
      "Conflict management for couples": [],
      "modified version of the Coping Cat program": [],
      "Sertraline": [
        "umls:orch",
        "umls:phsu"
      ],
      "MASSI": [
        "umls:amph"
      ],
      "Mindfulness Based Therapy (MBT)": [],
      "Multimodal Anxiety and Social Skills Intervention (MASSI) program": [],
      "(cognitive-behavioral therapy; CBT": [],
      "Multimodal Anxiety and Social Skills Intervention": [],
      "MBT": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:amph": 1,
      "umls:gngm": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "54fc9b236ad7dcbc12000005",
    "question": "List adenosine A2A receptor antagonists that are used for Parkinson\u0027s disease treatment.",
    "answer-types": {
      "preladenant": [
        "umls:orch",
        "umls:phsu"
      ],
      "istradefylline": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "533ba218fd9a95ea0d000007",
    "question": "What is the clinical indication of cardiac T1 mapping magnetic resonance?",
    "answer-types": {
      "detection  of myocardial fibrosis in nonischemic cardiomyopathies": []
    },
    "type-counts": {}
  },
  {
    "qid": "5540fbce234c5a7c75000001",
    "question": "Which autophagy pathway is trigered by the KFERQ motif of cytosolic proteins?",
    "answer-types": {
      "chaperone-mediated autophagy": [
        "umls:celf"
      ],
      "CMA": [
        "umls:orch",
        "umls:horm",
        "umls:phsu"
      ],
      "chaperone-mediated autophagy (CMA)": [
        "umls:celf"
      ]
    },
    "type-counts": {
      "umls:celf": 2,
      "umls:orch": 1,
      "umls:horm": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "52f77f042059c6d71c000029",
    "question": "Which are the clinical characteristics of TSC?",
    "answer-types": {
      "Pulmonary lymphangioleiomyomatosis": [
        "umls:neop"
      ],
      "mental detardation": [],
      "renal angiomyolipoma": [
        "umls:neop"
      ],
      "Brain lesions": [
        "umls:dsyn"
      ],
      "subependymal giant cell astrocytoma (SEGA)": [
        "umls:neop"
      ],
      "subependymal giant cell astrocytoma": [
        "umls:neop"
      ],
      "hepatic lesions": [
        "umls:fndg"
      ],
      "Lung lesions": [
        "umls:fndg"
      ],
      "Kidney lesions": [
        "umls:dsyn"
      ],
      "seizures": [
        "umls:sosy"
      ],
      "SEGA": [
        "umls:neop"
      ],
      "autism": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:sosy": 1,
      "umls:mobd": 1,
      "umls:neop": 5,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "54fe09036ad7dcbc12000009",
    "question": "List fish anti-freeze proteins.",
    "answer-types": {
      "anti-freeze protein-3": [],
      "AFP-III": [
        "umls:bacs",
        "umls:aapp"
      ],
      "AFP-I": [
        "umls:aapp"
      ],
      "anti-freeze glycoprotein": [],
      "AFP-II": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Thermal hysteresis protein": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 3,
      "umls:aapp": 4
    }
  },
  {
    "qid": "5343bdd6aeec6fbd07000001",
    "question": "Which is the phosphorylated residue in the promoter paused form of RNA polymerase II?",
    "answer-types": {
      "Serine 5": [
        "umls:orch"
      ]
    },
    "type-counts": {
      "umls:orch": 1
    }
  },
  {
    "qid": "517295c18ed59a060a000016",
    "question": "Name the major classes of small non coding RNAs in mammalians?",
    "answer-types": {
      "snoRNAs": [
        "umls:nnon",
        "umls:bacs"
      ],
      "scaRNAs": [],
      "miRNA": [
        "umls:nnon",
        "umls:bacs"
      ],
      "piRNAS": [
        "umls:nnon",
        "umls:bacs"
      ],
      "snRNA": [
        "umls:nnon",
        "umls:bacs"
      ]
    },
    "type-counts": {
      "umls:nnon": 4,
      "umls:bacs": 4
    }
  },
  {
    "qid": "5311bcc2e3eabad021000005",
    "question": "Describe a diet that reduces the chance of kidney stones.",
    "answer-types": {
      "reducing sodium": []
    },
    "type-counts": {}
  },
  {
    "qid": "5505c9008e1671127b000002",
    "question": "List the components of mTOR Complex 2 (mTORC2).",
    "answer-types": {
      "PRR5": [
        "umls:gngm"
      ],
      "mSin1": [
        "umls:aapp"
      ],
      "Rictor": [
        "umls:gngm"
      ],
      "mTOR": [
        "umls:enzy",
        "umls:aapp"
      ],
      "mLST8/GβL": []
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:gngm": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "52fe54252059c6d71c000079",
    "question": "Which proteins act as histone-like molecules in prokaryotes?",
    "answer-types": {
      "IHF": [
        "umls:bacs",
        "umls:aapp"
      ],
      "H-NS": [
        "umls:bacs",
        "umls:aapp"
      ],
      "HU": [
        "umls:geoa"
      ]
    },
    "type-counts": {
      "umls:geoa": 1,
      "umls:bacs": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "5326c6fed6d3ac6a3400000c",
    "question": "Which are the mains risk factors of metabolic syndrome?",
    "answer-types": {
      "Hypertension": [
        "umls:dsyn"
      ],
      "Obesity": [
        "umls:dsyn"
      ],
      "HDL": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Low high-density cholesterol (HDL) levels": [
        "umls:fndg"
      ],
      "High serum triglycerides": [
        "umls:fndg"
      ],
      "Dyslipidaemia": [
        "umls:dsyn"
      ],
      "High blood pressure": [
        "umls:dsyn"
      ],
      "Low high-density cholesterol": [
        "umls:fndg"
      ],
      "Diabetes type 2": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:fndg": 3,
      "umls:dsyn": 5,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5319a6c9b166e2b806000022",
    "question": "Which multiple kinase inhibitors are used in cancer therapy?",
    "answer-types": {
      "AG-013736": [
        "umls:orch",
        "umls:phsu"
      ],
      "sorafenib": [
        "umls:orch",
        "umls:phsu"
      ],
      "AEE 788": [
        "umls:orch",
        "umls:phsu"
      ],
      "ZD6474": [
        "umls:orch",
        "umls:phsu"
      ],
      "SU11248": [
        "umls:orch",
        "umls:phsu"
      ],
      "vatalanib": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 6,
      "umls:phsu": 6
    }
  },
  {
    "qid": "56a37e33496b62f23f000003",
    "question": "List types of avoided words in bacterial genomes",
    "answer-types": {
      "4, 5 and 6 bp palindromes": [],
      "Short palindromic sequences": [],
      "Short palindromic sequences (4, 5 and 6 bp palindromes)": [],
      "Palindromes corresponding to sites for restriction enzymes from other species": []
    },
    "type-counts": {}
  },
  {
    "qid": "5518414a15fa47643f000001",
    "question": "Which gene(s) should be genotyped in order to prescribe the drug Cetuximab (anti-EGFR)?",
    "answer-types": {
      "T53": [
        "umls:bact"
      ],
      "KRAS": [
        "umls:gngm"
      ],
      "BRAF": [
        "umls:gngm"
      ],
      "EGFR": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:rcpt": 1,
      "umls:gngm": 2,
      "umls:aapp": 1,
      "umls:bact": 1
    }
  },
  {
    "qid": "56ae57350a360a5e4500000a",
    "question": "Which is the physiological target for LeuRS translational quality control?",
    "answer-types": {
      "Norvaline": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:aapp": 1
    }
  },
  {
    "qid": "56e6ec49edfc094c1f000005",
    "question": "Which is the target of the drug Denosumab?",
    "answer-types": {
      "RANKL": [
        "umls:bacs",
        "umls:aapp"
      ],
      "receptor activator of nuclear factor-κB ligand": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "53357ca0d6d3ac6a3400004b",
    "question": "Which enzyme is inhibited by a drug fostamatinib?",
    "answer-types": {
      "spleen tyrosine kinase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "51542dabd24251bc0500007d",
    "question": "Which gene test can be used for the X-linked myotubular myopathy?",
    "answer-types": {
      "MTM1 gene test": [
        "umls:medd"
      ]
    },
    "type-counts": {
      "umls:medd": 1
    }
  },
  {
    "qid": "571ce13f7de986d80d000011",
    "question": "In which cells are gasdermins expressed?",
    "answer-types": {
      "epithelial cells": [
        "umls:cell"
      ]
    },
    "type-counts": {
      "umls:cell": 1
    }
  },
  {
    "qid": "550718e9fd1abe1741000001",
    "question": "Where in a protein can a signal sequence be found?",
    "answer-types": {
      "N-terminally": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56c1f039ef6e394741000052",
    "question": "Which antibody is implicated in the Bickerstaff\u0027s brainstem encephalitis?",
    "answer-types": {
      "antiganglioside antibody": [
        "umls:irda"
      ]
    },
    "type-counts": {
      "umls:irda": 1
    }
  },
  {
    "qid": "533c3533c45e133714000004",
    "question": "Which micro-RNAs have been associated in the pathogenesis of Rheumatoid Arthritis?",
    "answer-types": {
      "miR-124a": [
        "umls:gngm"
      ],
      "miR-146a": [
        "umls:gngm"
      ],
      "miR-15a": [
        "umls:gngm"
      ],
      "miR-18a": [
        "umls:gngm"
      ],
      "miR-223": [
        "umls:gngm"
      ],
      "miR-498": [
        "umls:gngm"
      ],
      "miR-16": [
        "umls:nnon"
      ],
      "miR-346": [
        "umls:gngm"
      ],
      "miR-203": [
        "umls:gngm"
      ],
      "miR-363": [
        "umls:gngm"
      ],
      "miR-132": [
        "umls:gngm"
      ],
      "miR-155": [
        "umls:gngm"
      ],
      "miR-222": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:gngm": 12
    }
  },
  {
    "qid": "52f112bb2059c6d71c000002",
    "question": "Which are the enzymes involved in the addition of 7-methylguanosine in mRNA?",
    "answer-types": {
      "RNMT-activating mini-protein": [
        "umls:gngm"
      ],
      "RNGTT": [
        "umls:gngm"
      ],
      "RNMT or hMTr1": [],
      "S-adenosylhomocysteine hydrolase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "RNMT-activating mini-protein (RAM)": [
        "umls:gngm"
      ],
      "RNA guanine-7 methyltransferase": [
        "umls:gngm"
      ],
      "SAHH": [
        "umls:gngm"
      ],
      "RNA guanine-7 methyltransferase (RNMT or hMTr1)": [
        "umls:enzy",
        "umls:aapp"
      ],
      "S-adenosylhomocysteine hydrolase (SAHH)": [
        "umls:enzy",
        "umls:aapp"
      ],
      "RNA guanylyltransferase and 5\u0027-phosphatase (RNGTT)": [
        "umls:gngm"
      ],
      "Myc": [
        "umls:bacs",
        "umls:aapp"
      ],
      "RNA guanylyltransferase and 5\u0027-phosphatase": [
        "umls:gngm"
      ],
      "RNA polymerase II": [
        "umls:enzy",
        "umls:aapp"
      ],
      "RAM": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:enzy": 4,
      "umls:bpoc": 1,
      "umls:bacs": 1,
      "umls:gngm": 7,
      "umls:aapp": 5
    }
  },
  {
    "qid": "55203ae78e534a4535000001",
    "question": "In which condition was protein S100A7 originally identified?",
    "answer-types": {
      "psoriasis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "514217a6d24251bc05000005",
    "question": "Which are the available biomedical text mining tools for the detection of protein-protein interactions?",
    "answer-types": {
      "PPI finder": [],
      "Protopia": [],
      "eFIP": [],
      "Textomy": [],
      "PreBIND": [],
      "STRING": [
        "umls:medd"
      ],
      "Extracting Functional Impact of Phosphorylation": [],
      "GeneView": [],
      "BioMap": []
    },
    "type-counts": {
      "umls:medd": 1
    }
  },
  {
    "qid": "532670e7d6d3ac6a34000008",
    "question": "What is the typical alteration of the thyroid profile metabolism early after coronary artery bypass graft surgery?",
    "answer-types": {
      "Low T3 syndrome occurs frequently after CABG": []
    },
    "type-counts": {}
  },
  {
    "qid": "5358e067f1005d6b5800000b",
    "question": "Which proteins are involved in actin bundling and filopodia formation and function?",
    "answer-types": {
      "VASP": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Diaphanous-related formin": [
        "umls:gngm"
      ],
      "Insulin receptor tyrosine kinase substrate p53 (IRSp53)": [],
      "Diaphanous-related formin (dDia2)": [
        "umls:gngm"
      ],
      "Cysteine-rich protein 1": [
        "umls:gngm"
      ],
      "Cysteine-rich protein 1 (CRP1)": [
        "umls:gngm"
      ],
      "Missing in metastasis protein (MIM)": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Missing in metastasis protein": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Macrophage actin-associated tyrosine phosphorylated protein (MAYP/PSTPIP2)": [
        "umls:gngm"
      ],
      "Insulin receptor tyrosine kinase substrate p53": [],
      "Vasodilator-stimulated phosphoprotein": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Fascin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "CRP1": [
        "umls:gngm"
      ],
      "MIM": [
        "umls:gngm"
      ],
      "Vasodilator-stimulated phosphoprotein (VASP)": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Eps8": [
        "umls:gngm"
      ],
      "MAYP/PSTPIP2": [],
      "IRSp53": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Macrophage actin-associated tyrosine phosphorylated protein": [
        "umls:gngm"
      ],
      "dDia2": []
    },
    "type-counts": {
      "umls:gngm": 9,
      "umls:bacs": 7,
      "umls:aapp": 7
    }
  },
  {
    "qid": "56b76f496e3f8eaf4c000002",
    "question": "What does the SAGA complex acronym stands for?",
    "answer-types": {
      "Spt-Ada-Gcn5-acetyltransferase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56cae60f5795f9a73e00002b",
    "question": "Which polyQ tract protein is linked to Spinocerebellar Ataxia type 2?",
    "answer-types": {
      "Ataxin 2": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56e0447a51531f7e3300000b",
    "question": "Which are the smallest known subviral pathogens of plants?",
    "answer-types": {
      "Viroids": [
        "umls:virs"
      ]
    },
    "type-counts": {
      "umls:virs": 1
    }
  },
  {
    "qid": "56bb621fac7ad10019000009",
    "question": "What causes Katayama Fever?",
    "answer-types": {
      "Schistosoma spp": []
    },
    "type-counts": {}
  },
  {
    "qid": "52f893f92059c6d71c00003c",
    "question": "List clinical trials for prevention of sarcopenia",
    "answer-types": {
      "androgen replacement trials": [],
      "NCT00794079": [],
      "omega-3 fatty acid supplementation": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "554140ad182542114d000003",
    "question": "Which is the database of molecular recognition features in membrane proteins?",
    "answer-types": {
      "mpMoRFsDB": []
    },
    "type-counts": {}
  },
  {
    "qid": "554148c23f2354b713000001",
    "question": "Which database is available for the identification of chorion proteins in Lepidopteran proteomes?",
    "answer-types": {
      "LepChorionDB": []
    },
    "type-counts": {}
  },
  {
    "qid": "56cb9b065795f9a73e000032",
    "question": "Which kinase is inhibited by Tripolin A?",
    "answer-types": {
      "Aurora A": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52d1389303868f1b06000032",
    "question": "List the existing methods for genetic manipulation of cells.",
    "answer-types": {
      "Microinjection": [
        "umls:topp"
      ],
      "liposomes": [
        "umls:orch"
      ],
      "via viral vectors": [],
      "electroporation": [
        "umls:lbpr"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:lbpr": 1,
      "umls:topp": 1
    }
  },
  {
    "qid": "56bdfa73ef6e394741000003",
    "question": "List symptoms of Hakim Triad.",
    "answer-types": {
      "gait disturbances": [
        "umls:fndg"
      ],
      "dementia": [
        "umls:mobd"
      ],
      "urinary incontinence": [
        "umls:patf"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:patf": 1,
      "umls:mobd": 1
    }
  },
  {
    "qid": "53188480b166e2b806000018",
    "question": "Which is the cellular target of gefitinib?",
    "answer-types": {
      "Epidermal growth factor receptor (EGFR)": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "Epidermal growth factor receptor": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "EGFR": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 3,
      "umls:rcpt": 3,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56f96333cf1c325851000004",
    "question": "What kind of bonds are connecting keratin molecules?",
    "answer-types": {
      "amide bonds": [],
      "cystine disulfide bonds": [],
      "hydrogen bonds": [
        "umls:npop"
      ]
    },
    "type-counts": {
      "umls:npop": 1
    }
  },
  {
    "qid": "52c7311903868f1b0600001d",
    "question": "How many different mutations have been associated with Muenke syndrome?",
    "answer-types": {
      "One": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "54ede76294afd61504000008",
    "question": "What is the risk of developing acute myelogenous leukemia in Fanconi anemia?",
    "answer-types": {
      "At least 15%, based on the International Fanconi Anemia Registry": [],
      "At least 15%, based on the International Fanconi Anemia Registry (IFAR)": [],
      "IFAR": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:rcpt": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "571366ba1174fb1755000005",
    "question": "How can the fetal Rhesus be determined with non-invasive testing?",
    "answer-types": {
      "free fetal DNA from maternal cirulcation": []
    },
    "type-counts": {}
  },
  {
    "qid": "54c90dabf693c3b16b000004",
    "question": "Which genes have been proposed as potential candidates for gene therapy of heart failure?",
    "answer-types": {
      "(I-1)": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "(YAP)": [
        "umls:gngm"
      ],
      "S100A1": [
        "umls:gngm"
      ],
      "Yes Associated Protein": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Inhibitor 1 of Protein Phosphatase 1B": [
        "umls:gngm"
      ],
      "Protein Phosphatase 1B": [
        "umls:enzy",
        "umls:aapp"
      ],
      "(SERCA2A)": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Sarco-Endoplasmic Reticulum Calcium ATPase 2A": [],
      "Survivin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "(PP1B)": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:rcpt": 1,
      "umls:bacs": 2,
      "umls:gngm": 4,
      "umls:aapp": 5
    }
  },
  {
    "qid": "54f1e031c409818c32000001",
    "question": "DX-88 is investigational name of which drug?",
    "answer-types": {
      "Ecallantide": [
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56c4d14ab04e159d0e000003",
    "question": "Do the Sleeping Beauty or the piggyBac transposons have higher transposition efficiency?",
    "answer-types": {
      "piggyBac": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "52f8995b2059c6d71c00004a",
    "question": "Which genes have been found to be associated with restless leg syndrome",
    "answer-types": {
      "The genotypes of five specific single-nucleotide polymorphisms (SNPs) in three genes": [],
      "MEIS1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Intragenic guanosine triphosphate cyclohydrolase-1 duplication": [],
      "Homozygosity for the T-allele of BTBD9 rs9296249": [],
      "SNPs": [
        "umls:nusq"
      ],
      "Human L-Ferritin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "LRRK2 gene mutation": [
        "umls:lbpr"
      ],
      "The genotypes of five specific single-nucleotide polymorphisms": []
    },
    "type-counts": {
      "umls:lbpr": 1,
      "umls:nusq": 1,
      "umls:bacs": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "530cf4d5e2bfff940c000003",
    "question": "Which are the known inhibitors of the TPL2/MAP3K8 protein?",
    "answer-types": {
      "indazoles": [
        "umls:orch"
      ],
      "thieno-pyrimidines": [],
      "quinoline-3-carbonitriles": []
    },
    "type-counts": {
      "umls:orch": 1
    }
  },
  {
    "qid": "52bf1dea03868f1b06000012",
    "question": "What are the side effects of Nalmefene?",
    "answer-types": {
      "(horses) some passage of semifluid fecal material": [],
      "fatigue": [
        "umls:sosy"
      ],
      "(horses) intermittent penile relaxation": [],
      "increased self-rated alertness": [],
      "(horses) mild sedation": [],
      "reduced caloric intake / apetite": [],
      "dizziness / lightheadedness": [
        "umls:fndg"
      ],
      "decreased tiredness": [],
      "vomiting": [
        "umls:sosy"
      ],
      "nausea": [
        "umls:sosy"
      ],
      "insomnia": [
        "umls:sosy"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:sosy": 4
    }
  },
  {
    "qid": "530cf4d5e2bfff940c000004",
    "question": "Which are the most common methods for gene prioritization analysis?",
    "answer-types": {
      "network-based methods": []
    },
    "type-counts": {}
  },
  {
    "qid": "513ce494bee46bd34c000009",
    "question": "Which is the most common disease attributed to malfunction or absence of primary cilia?",
    "answer-types": {
      "Polycystic kidney disease (PKD)": [
        "umls:dsyn"
      ],
      "PKD": [
        "umls:gngm"
      ],
      "Polycystic kidney disease": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 2,
      "umls:gngm": 1
    }
  },
  {
    "qid": "56c86aa95795f9a73e000018",
    "question": "Treprostinil is an analogue for which prostaglandin?",
    "answer-types": {
      "Prostaglandin I(2)": [
        "umls:orch",
        "umls:bacs",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:bacs": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "571f5e740fd6f91b6800000b",
    "question": "Which enzyme is deficient in Gaucher\u0027s disease?",
    "answer-types": {
      "Beta glucocerebrosidase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "55376f19bc4f83e82800000c",
    "question": "Which is the most common type of pediatric cerebellar tumor?",
    "answer-types": {
      "Medulloblastoma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "5319a7d2b166e2b806000029",
    "question": "Which is the E3 ubiquitin ligase of Hsp90?",
    "answer-types": {
      "Carboxyl terminus of hsc70-interacting protein (CHIP)": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Carboxyl terminus of hsc70-interacting protein": [
        "umls:enzy",
        "umls:aapp"
      ],
      "CHIP": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:orch": 1,
      "umls:phsu": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "55439140ed966d112c00000a",
    "question": "Which are the major phycobiliproteins present in cyanobacteria?",
    "answer-types": {
      "C-Phycocyanin (C-Pc)": [
        "umls:bacs",
        "umls:aapp"
      ],
      "R-phycoerythrin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "C-Phycocyanin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "C-Pc": [
        "umls:orch"
      ],
      "APC": [
        "umls:cell"
      ],
      "R-PE": [
        "umls:bact"
      ],
      "B-Phycoerythrin (B-PE)": [],
      "B-Phycoerythrin": [],
      "allophycocyanin": [
        "umls:aapp"
      ],
      "allophycocyanin (APC)": [
        "umls:aapp"
      ],
      "B-PE": [
        "umls:orch"
      ],
      "R-phycoerythrin (R-PE)": []
    },
    "type-counts": {
      "umls:cell": 1,
      "umls:orch": 2,
      "umls:bacs": 3,
      "umls:bact": 1,
      "umls:aapp": 5
    }
  },
  {
    "qid": "5547a01cf35db75526000005",
    "question": "In which kingdom do microsporidia belong, according to their current classification scheme?",
    "answer-types": {
      "Fungi": [
        "umls:fngs"
      ]
    },
    "type-counts": {
      "umls:fngs": 1
    }
  },
  {
    "qid": "51656c94298dcd4e51000058",
    "question": "What is the inheritance pattern of Emery-Dreifuss muscular dystrophy?",
    "answer-types": {
      "X-linked": [
        "umls:genf"
      ],
      "autosomal dominant": [
        "umls:genf"
      ],
      "autosomal recessive": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 3
    }
  },
  {
    "qid": "56b710f276d8bf8d13000003",
    "question": "What is the effect of a defective CLN3 gene?",
    "answer-types": {
      "Batten disease": [
        "umls:dsyn"
      ],
      "juvenile-onset neuronal ceroid lipofuscinosis": [],
      "JNCL": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 2
    }
  },
  {
    "qid": "517539ca8ed59a060a000027",
    "question": "Which genes are regulated by TRalpha2 in the heart?",
    "answer-types": {
      "p38": [
        "umls:moft"
      ],
      "TAK1": [
        "umls:gngm"
      ],
      "ARB1": [
        "umls:gngm"
      ],
      "ARB2": [
        "umls:gngm"
      ],
      "TRalpha1": []
    },
    "type-counts": {
      "umls:moft": 1,
      "umls:gngm": 3
    }
  },
  {
    "qid": "554143ad182542114d000004",
    "question": "List available methods for transmembrane protein topology prediction.",
    "answer-types": {
      "MEMSAT3": [],
      "HMM-TM": [],
      "HMMTOP": [],
      "MetaTM": [],
      "Phobius": [],
      "SignalP": [
        "umls:inpr"
      ],
      "HMM_RA": [],
      "Philius": [],
      "TMHMM": [
        "umls:inpr"
      ],
      "HMMpTM": []
    },
    "type-counts": {
      "umls:inpr": 2
    }
  },
  {
    "qid": "56b739d976d8bf8d13000005",
    "question": "List available genetic multicolor cell labeling techiniques in Drosophila",
    "answer-types": {
      "Drosophila Brainbow": [],
      "Flybow": []
    },
    "type-counts": {}
  },
  {
    "qid": "5319abffb166e2b80600002f",
    "question": "Which growth factors are known to be involved in the induction of EMT?",
    "answer-types": {
      "IGF-I": [
        "umls:bacs",
        "umls:aapp"
      ],
      "EGF": [
        "umls:bacs",
        "umls:aapp"
      ],
      "GF-β": [],
      "Sonic Hedgehog (SHh)": [
        "umls:gngm"
      ],
      "CCN family": [
        "umls:bacs",
        "umls:aapp"
      ],
      "FGFs": [
        "umls:bacs",
        "umls:aapp"
      ],
      "bFGF": [
        "umls:bacs",
        "umls:aapp"
      ],
      "fibroblast growth factors": [
        "umls:bacs",
        "umls:aapp"
      ],
      "fibroblast growth factors (FGFs)": [
        "umls:bacs",
        "umls:aapp"
      ],
      "SHh": [
        "umls:bacs",
        "umls:aapp"
      ],
      "TNF-α": [
        "umls:imft",
        "umls:aapp"
      ],
      "Notch1": [
        "umls:gngm"
      ],
      "Sonic Hedgehog": [
        "umls:gngm"
      ],
      "TGF-β1": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "TGF-β2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Wnt": [
        "umls:bacs",
        "umls:aapp"
      ],
      "IGF-II": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 1,
      "umls:gngm": 3,
      "umls:bacs": 12,
      "umls:phsu": 1,
      "umls:aapp": 13
    }
  },
  {
    "qid": "5319a6e9b166e2b806000023",
    "question": "Which is the genetic lesion associated with Huntington’s disease?",
    "answer-types": {
      "A CAG trinucleotide repeat expansion in the HD gene": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c703445795f9a73e00000a",
    "question": "Which histone modification discriminates between active and poised enhancers?",
    "answer-types": {
      "H3K4me1": [
        "umls:aapp"
      ],
      "H3K27ac": [
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      ]
    },
    "type-counts": {
      "umls:aapp": 2
    }
  },
  {
    "qid": "56c344abfedd0b786b000003",
    "question": "What are the properties of super-enhancers?",
    "answer-types": {
      "associated with genes driving cell differentiation": [],
      "their magnitude of size": [],
      "binding of transcriptional machinery": [],
      "transcription factor density": []
    },
    "type-counts": {}
  },
  {
    "qid": "52bf208003868f1b06000019",
    "question": "What is the inheritance pattern of Li–Fraumeni syndrome?",
    "answer-types": {
      "Autosomal dominant": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "514a51c2d24251bc0500005c",
    "question": "Which pituitary adenoma is common cause of infertility is women?",
    "answer-types": {
      "prolactinoma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "534bb147aeec6fbd07000014",
    "question": "Which are the cardiac effects of thyronamines?",
    "answer-types": {
      "negative chronotropy": [
        "umls:ortf"
      ],
      "reduced cardiac output": [
        "umls:topp"
      ],
      "resistance to ischemic injury": [],
      "negative inotropy": [
        "umls:ortf"
      ],
      "lower heart rate": [
        "umls:patf"
      ]
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:topp": 1,
      "umls:ortf": 2
    }
  },
  {
    "qid": "55086ea1098a1b487b000001",
    "question": "Matuzumab has been tested for treatment of which cancers?",
    "answer-types": {
      "esophageal": [
        "umls:dsyn"
      ],
      "gastric": [
        "umls:bpoc"
      ],
      "ovarian": [
        "umls:bpoc"
      ],
      "colorectal": [
        "umls:spco"
      ],
      "primary peritoneal": [
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      ],
      "pancreatic": [
        "umls:bpoc"
      ],
      "cervical": [
        "umls:blor"
      ],
      "non-small cell lung": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:spco": 1,
      "umls:neop": 2,
      "umls:bpoc": 3,
      "umls:dsyn": 1,
      "umls:blor": 1
    }
  },
  {
    "qid": "5171651e8ed59a060a000009",
    "question": "Which are the synonyms of prostate-specific antigen?",
    "answer-types": {
      "hK3": [
        "umls:moft"
      ],
      "human kallikrein-related peptidase 3": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:moft": 1,
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56b397a98525abca1e000003",
    "question": "What is the lipid droplet used for in the cell?",
    "answer-types": {
      "lipid storage and lipid mobilization": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c58ceeb04e159d0e000004",
    "question": "What is the function of circular RNA?",
    "answer-types": {
      "miRNA": [
        "umls:nnon",
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      ],
      "Recent research has revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression.": [],
      "Recent research has revealed that circRNAs can function as microRNA": []
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:bacs": 1
    }
  },
  {
    "qid": "55414c65472cfd8617000001",
    "question": "List available biomedical question answering systems.",
    "answer-types": {
      "askHERMES": [],
      "EAGLi": [],
      "INDOC": [],
      "HONQA": []
    },
    "type-counts": {}
  },
  {
    "qid": "517a8c238ed59a060a000042",
    "question": "Which dediodinases are present in kidney?",
    "answer-types": {
      "Type 1 deiodinase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Tipe 3 deiodinase": []
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54edf72c94afd61504000013",
    "question": "What is the presumed key event in Fanconi anemia pathogenesis?",
    "answer-types": {
      "FANCD2 monoubiquitination": []
    },
    "type-counts": {}
  },
  {
    "qid": "56d138fe3975bb303a000015",
    "question": "Which trancription factor activates the betalain pathway?",
    "answer-types": {
      "The beet Y locus encodes an anthocyanin MYB-like protein that activates the betalain red pigment pathway.": []
    },
    "type-counts": {}
  },
  {
    "qid": "530e1c985937551c09000004",
    "question": "List common symptoms of patients with the DOORS syndrome.",
    "answer-types": {
      "mental retardation": [
        "umls:mobd"
      ],
      "seizures": [
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      ],
      "onychodystrophy": [
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      ],
      "deafness": [
        "umls:fndg"
      ],
      "osteodystrophy": [
        "umls:cgab",
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:sosy": 1,
      "umls:cgab": 1,
      "umls:mobd": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "512d2fff5274a5fb07000006",
    "question": "Is the H3K4me3 histone mark related to transcriptional initiation or elongation?",
    "answer-types": {
      "transcriptional initiation": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "515db3d8298dcd4e51000015",
    "question": "What is the average diameter of intermediate filaments?",
    "answer-types": {
      "10 nm": [
        "_QUANTITY"
      ],
      "10 nanometers": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 2
    }
  },
  {
    "qid": "5326a85ad6d3ac6a3400000b",
    "question": "What does polyadenylate-binding protein 4 (PABP4) bind to?",
    "answer-types": {
      "PABP4  binds mRNA poly(A) tails.": []
    },
    "type-counts": {}
  },
  {
    "qid": "51680a6d298dcd4e51000063",
    "question": "What is the function of cryptochrome-1 in mouse?",
    "answer-types": {
      "component of the central and peripheral circadian clocks for generation of circadian rhythms in mice": []
    },
    "type-counts": {}
  },
  {
    "qid": "5540ca8a0083d1bf0e000003",
    "question": "Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?",
    "answer-types": {
      "Nestin": [
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        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "51585b28d24251bc0500008d",
    "question": "Which enzyme is involved in the maintenance of DNA (cytosine-5-)-methylation?",
    "answer-types": {
      "MET1": [
        "umls:gngm"
      ],
      "DNMT1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 2
    }
  },
  {
    "qid": "515dd3d5298dcd4e5100001c",
    "question": "In what proportion of children with heart failure has Enalapril been shown to be safe and effective?",
    "answer-types": {
      "50% to 80%": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "516c0ebc298dcd4e5100006e",
    "question": "Which genes does thyroid hormone receptor beta1 regulate in the liver?",
    "answer-types": {
      "ChREBP": [
        "umls:gngm"
      ],
      "Carbohydrate response element binding protein": [
        "umls:gngm"
      ],
      "cytochrome P450 oxidoreductase": [
        "umls:gngm"
      ],
      "ME": [
        "umls:dsyn"
      ],
      "malic enzyme": [
        "umls:enzy",
        "umls:aapp"
      ],
      "LDL receptor": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:dsyn": 1,
      "umls:rcpt": 1,
      "umls:gngm": 3,
      "umls:aapp": 2
    }
  },
  {
    "qid": "54e262daae9738404b000018",
    "question": "Which cell type has the protein Chromogranin A as marker?",
    "answer-types": {
      "neuroendocrine cells": [
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      ]
    },
    "type-counts": {
      "umls:cell": 1
    }
  },
  {
    "qid": "5713b0a51174fb175500000e",
    "question": "Which disease phenotypes are associated to PRPS1 mutations?",
    "answer-types": {
      "X-linked Charcot-Marie-Tooth disease type 5 (CMTX5)": [],
      "Non-syndromic sensorineural deafness (DFN2)": [],
      "Arts syndrome": [
        "umls:dsyn"
      ],
      "CMTX5": [
        "umls:gngm"
      ],
      "X-linked Charcot-Marie-Tooth disease type 5": [],
      "DFN2": [
        "umls:dsyn"
      ],
      "Non-syndromic sensorineural deafness": []
    },
    "type-counts": {
      "umls:dsyn": 2,
      "umls:gngm": 1
    }
  },
  {
    "qid": "56c8605b5795f9a73e000014",
    "question": "Which kinases does baricitinib inhibit?",
    "answer-types": {
      "JAK2": [
        "umls:enzy",
        "umls:aapp"
      ],
      "JAK1": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "550b0408c2af5d5b7000000c",
    "question": "Magnetic beads has been used in numerous applications. List some coatings used.",
    "answer-types": {
      "streptavidin": [
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        "umls:bacs",
        "umls:aapp"
      ],
      "C8": [
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        "umls:aapp"
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      "concanavalin A": [
        "umls:bacs",
        "umls:aapp"
      ],
      "carboxylic-modified": [],
      "SELEX library": [],
      "oligo(dT)": [
        "umls:nnon"
      ],
      "enzymes": [
        "umls:enzy",
        "umls:aapp"
      ],
      "antibodies": [
        "umls:imft",
        "umls:aapp"
      ],
      "C18": [
        "umls:gngm"
      ],
      "aptamers": [
        "umls:nnon"
      ],
      "synthesized DNA": [],
      "TiO2": [
        "umls:inch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:nnon": 2,
      "umls:inch": 1,
      "umls:enzy": 1,
      "umls:irda": 1,
      "umls:imft": 2,
      "umls:gngm": 1,
      "umls:bacs": 2,
      "umls:phsu": 1,
      "umls:aapp": 5
    }
  },
  {
    "qid": "56d1f790f22319765a000001",
    "question": "Which gene harbors the mutation T790M?",
    "answer-types": {
      "epidermal growth factor receptor": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "EGFR": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:rcpt": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "51477de5d24251bc05000020",
    "question": "Tumors of which three organs are classically associated with the multiple endocrine neoplasia type 1 syndrome?",
    "answer-types": {
      "parathyroid gland": [
        "umls:bpoc"
      ],
      "pancreas": [
        "umls:bpoc"
      ],
      "pituitary gland": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 3
    }
  },
  {
    "qid": "57138eb21174fb175500000a",
    "question": "Which is the protein implicated in Spinocerebellar ataxia type 3?",
    "answer-types": {
      "Ataxin-3": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:aapp": 1
    }
  },
  {
    "qid": "513ce5f2bee46bd34c00000a",
    "question": "Which is the prevalence of cystic fibrosis in the human population?",
    "answer-types": {
      "0.7–7/100000 inhabitants": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "5524562387ecba3764000001",
    "question": "Which are the different homologs or family members of the hedgehog proteins in mammals?",
    "answer-types": {
      "Desert hedgehog": [
        "umls:gngm"
      ],
      "Sonic hedgehog": [
        "umls:gngm"
      ],
      "SHH": [
        "umls:bacs",
        "umls:aapp"
      ],
      "DHH": [
        "umls:gngm"
      ],
      "Indian hedgehog": [
        "umls:gngm"
      ],
      "IHH": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1,
      "umls:bacs": 1,
      "umls:gngm": 4,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5505a587f73303d458000005",
    "question": "What does mTOR stands for?",
    "answer-types": {
      "mammalian target of rapamycin": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "51486f7dd24251bc0500002e",
    "question": "Which scales are recommended by the American Heart Association for depression screening in cardiovascular patients?",
    "answer-types": {
      "patient health questionnaire-2": [
        "umls:inpr"
      ],
      "patient health questionnaire-9": [
        "umls:inpr"
      ]
    },
    "type-counts": {
      "umls:inpr": 2
    }
  },
  {
    "qid": "56cf236f3975bb303a000002",
    "question": "Which calcium channels does ethosuximide target?",
    "answer-types": {
      "T-type calcium channels": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "55201a316b348bb82c000019",
    "question": "What is the sedimentation coefficient of the mammalian mitoribosome?",
    "answer-types": {
      "55 S": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52ef7754c8da898910000014",
    "question": "Which proteins act as histone-like molecules in prokaryotes?",
    "answer-types": {
      "IHF": [
        "umls:bacs",
        "umls:aapp"
      ],
      "H-NS": [
        "umls:bacs",
        "umls:aapp"
      ],
      "HU": [
        "umls:geoa"
      ]
    },
    "type-counts": {
      "umls:geoa": 1,
      "umls:bacs": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "55032efde9bde69634000035",
    "question": "Which receptor is targeted by telcagepant?",
    "answer-types": {
      "calcitonin gene-related peptide": [
        "umls:horm",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:horm": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5319a724b166e2b806000025",
    "question": "Which trinucleotide repeat disorders are affecting the nervous system?",
    "answer-types": {
      "FRAXE": [
        "umls:dsyn"
      ],
      "Dentatorubral-pallidoluysian atrophy": [
        "umls:dsyn"
      ],
      "X-linked spinal and bulbar muscular atrophy (SBMA)": [
        "umls:dsyn"
      ],
      "SBMA": [
        "umls:gngm"
      ],
      "SCA1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Fragile X syndrome of mental retardation (FRAXE)": [
        "umls:dsyn"
      ],
      "X-linked spinal and bulbar muscular atrophy": [
        "umls:dsyn"
      ],
      "Huntington\u0027s disease": [
        "umls:dsyn"
      ],
      "Fragile X syndrome of mental retardation": [
        "umls:dsyn"
      ],
      "Spinocerebellar ataxia type 1 (SCA1)": [
        "umls:dsyn"
      ],
      "DRPLA": [
        "umls:dsyn"
      ],
      "Fragile X syndrome of mental retardation (FRAXA)": [
        "umls:dsyn"
      ],
      "Spinocerebellar ataxia type 1": [
        "umls:dsyn"
      ],
      "HD": [
        "umls:patf"
      ],
      "Huntington\u0027s disease (HD)": [
        "umls:dsyn"
      ],
      "Dentatorubral-pallidoluysian atrophy (DRPLA)": [
        "umls:dsyn"
      ],
      "FRAXA": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:dsyn": 14,
      "umls:bacs": 1,
      "umls:gngm": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "53188992b166e2b806000019",
    "question": "Which are the cellular targets of imatinib mesylate?",
    "answer-types": {
      "Platelet-derived growth factor receptor (PDGFR)": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "c-Kit": [
        "umls:gngm"
      ],
      "BCR-ABL": [
        "umls:gngm"
      ],
      "Platelet-derived growth factor receptor": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "PDGFR": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 3,
      "umls:rcpt": 3,
      "umls:gngm": 2,
      "umls:aapp": 3
    }
  },
  {
    "qid": "52ebb2c698d0239505000029",
    "question": "Which are the clinical characteristics of Tuberous Sclerosis?",
    "answer-types": {
      "epilepsy": [
        "umls:dsyn"
      ],
      "mental retardation": [
        "umls:mobd"
      ],
      "renal angiomyolipomas": [
        "umls:dsyn"
      ],
      "rhabdomyoma": [
        "umls:neop"
      ],
      "angiofibromas": [
        "umls:neop"
      ],
      "cortical tubers": [
        "umls:fndg"
      ],
      "behavioral disorders": [
        "umls:mobd"
      ],
      "subependymal giant cell astrocytomas": [
        "umls:neop"
      ],
      "neurofibromas": [
        "umls:neop"
      ],
      "lymphangioleiomyomatosis": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:mobd": 2,
      "umls:neop": 5,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "54f0920f94afd61504000018",
    "question": "List drugs included in the DHAP-R chemotherapy regiment.",
    "answer-types": {
      "dexamethasone": [
        "umls:orch",
        "umls:phsu"
      ],
      "cytarabine": [
        "umls:nnon",
        "umls:phsu"
      ],
      "cisplatin": [
        "umls:inch",
        "umls:phsu"
      ],
      "rituximab": [
        "umls:imft",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:inch": 1,
      "umls:orch": 1,
      "umls:imft": 1,
      "umls:aapp": 1,
      "umls:phsu": 4
    }
  },
  {
    "qid": "57220e400fd6f91b68000015",
    "question": "Which are the most common symptoms in Lambert-Eaton Myasthenic Syndrome?",
    "answer-types": {
      "fatigability": [
        "umls:sosy"
      ],
      "autonomic symptoms": [
        "umls:fndg"
      ],
      "small-cell lung cancer": [
        "umls:neop"
      ],
      "proximal limb muscle weakness": [
        "umls:fndg"
      ],
      "decreased deep-tendon reflexes": [
        "umls:sosy"
      ]
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:sosy": 2,
      "umls:neop": 1
    }
  },
  {
    "qid": "553babc0f321868558000007",
    "question": "Which types of bacterial microflora are associated with the progression of peri-implantitis?",
    "answer-types": {
      "P. gingivalis": [
        "umls:aapp"
      ],
      "A. actinomycetemcomitans": [
        "umls:bact"
      ],
      "F. nucleatum": [],
      "T. denticola": [],
      "P. intermedia": [
        "umls:fngs"
      ],
      "T. forsythia": []
    },
    "type-counts": {
      "umls:fngs": 1,
      "umls:bact": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5162c8a8298dcd4e51000047",
    "question": "What are the known families of deadenylases?",
    "answer-types": {
      "PAN2": [
        "umls:gngm"
      ],
      "2\u0027-PDE": [
        "umls:gngm"
      ],
      "POP2": [
        "umls:gngm"
      ],
      "PARN": [
        "umls:gngm"
      ],
      "Nocturnin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "ANGEL": [
        "umls:orch",
        "umls:phsu"
      ],
      "CCR4": [
        "umls:gngm"
      ],
      "CAF1Z": []
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:bacs": 1,
      "umls:gngm": 5,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "553656c4bc4f83e828000009",
    "question": "Which translocation is harbored in the Askin tumor cells?",
    "answer-types": {
      "reciprocal translocation t(11;22) (q24;q12)": []
    },
    "type-counts": {}
  },
  {
    "qid": "56bdcc4cef6e394741000002",
    "question": "Which R/bioconductor package utilizes the Hilbert curve in order to visualize genomic data?",
    "answer-types": {
      "HilbertVis": []
    },
    "type-counts": {}
  },
  {
    "qid": "56a3bf0f496b62f23f00000a",
    "question": "Which packages are used for performing overlap analysis of genomic regions in R/bioconductor?",
    "answer-types": {
      "IRanges": [],
      "GenomicRanges": [],
      "GenomicFeatures": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c1d856ef6e394741000032",
    "question": "Which pathway is activated by ficolin-3?",
    "answer-types": {
      "lectin complement pathway": [
        "umls:moft"
      ]
    },
    "type-counts": {
      "umls:moft": 1
    }
  },
  {
    "qid": "516281e6298dcd4e51000040",
    "question": "Global quantitative phosphoproteomic analyses are emerging. List the preferred technologies for the enrichment for phosphorylated peptides?",
    "answer-types": {
      "antiphosphotyrosine antibodies": [],
      "enriched for phosphorylated peptides using titanium dioxide": [],
      "simple derivatization procedure based on phosphoramidate chemistry": [],
      "sequential elution from IMAC": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c3326750c68dd41600000b",
    "question": "Which histone modifications are correlated with transcription elongation?",
    "answer-types": {
      "H3K36me3": []
    },
    "type-counts": {}
  },
  {
    "qid": "54d646403706e89528000008",
    "question": "List disorders that have been associated to the polymorphism rs2535629.",
    "answer-types": {
      "major depressive disorder": [
        "umls:mobd"
      ],
      "schizophrenia": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:mobd": 2
    }
  },
  {
    "qid": "56c1f01aef6e394741000043",
    "question": "What is targeted by monoclonal antibody Pembrolizumab?",
    "answer-types": {
      "programmed cell death 1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "52e8e93498d023950500001e",
    "question": "What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?",
    "answer-types": {
      "autosomal dominant": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "534df8c9aeec6fbd07000016",
    "question": "List diseases where protein citrullination plays an important role.",
    "answer-types": {
      "Multiple Sclerosis": [
        "umls:dsyn"
      ],
      "Prion Diseases": [
        "umls:dsyn"
      ],
      "Rheumatoid Arthritis": [
        "umls:dsyn"
      ],
      "Alzheimer disease": [
        "umls:dsyn"
      ],
      "Cancer": [
        "umls:neop"
      ],
      "RA": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:neop": 1,
      "umls:dsyn": 5
    }
  },
  {
    "qid": "53035d7c2059c6d71c000085",
    "question": "What is commotio cordis?",
    "answer-types": {
      "blunt thoracic impact causing sudden death": []
    },
    "type-counts": {}
  },
  {
    "qid": "56bb68f9ac7ad1001900000b",
    "question": "What is the cause of Phthiriasis Palpebrarum?",
    "answer-types": {
      "Pthirus pubis": [
        "umls:euka"
      ]
    },
    "type-counts": {
      "umls:euka": 1
    }
  },
  {
    "qid": "56c1f020ef6e394741000047",
    "question": "Which disorder is rated by Palmini classification?",
    "answer-types": {
      "focal cortical dysplasia": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "54f9ae2506d9727f76000002",
    "question": "Which gene is mutated in a subtype of arrhythmogenic right ventricular cardiomyopathy known as Naxos disease?",
    "answer-types": {
      "plakoglobin[jup]": [
        "umls:fndg"
      ],
      "The Plakoglobin gene": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:gngm": 1
    }
  },
  {
    "qid": "56e30dd551531f7e33000016",
    "question": "List core circadian clock genes.",
    "answer-types": {
      "Cry": [
        "umls:inbe"
      ],
      "Per": [
        "umls:geoa"
      ],
      "BMAL1": [
        "umls:gngm"
      ],
      "CLOCK": [
        "umls:gngm"
      ],
      "CKlε": []
    },
    "type-counts": {
      "umls:inbe": 1,
      "umls:geoa": 1,
      "umls:gngm": 2
    }
  },
  {
    "qid": "5713c8d71174fb1755000015",
    "question": "Which peripheral neuropathy has been associated with NDRG1 mutations?",
    "answer-types": {
      "Charcot-Marie-Tooth (CMT) 4D disease": [
        "umls:dsyn"
      ],
      "Charcot-Marie-Tooth": [
        "umls:dsyn"
      ],
      "CMT": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 3
    }
  },
  {
    "qid": "51bdd9c2047fa84d1d000002",
    "question": "Which is the receptor for substrates of Chaperone Mediated Autophagy?",
    "answer-types": {
      "Lysosome-associated membrane protein 2 isoform A": [],
      "LAMP2A": []
    },
    "type-counts": {}
  },
  {
    "qid": "52f509512059c6d71c000020",
    "question": "What is the mode of inheritance of short QT syndrome?",
    "answer-types": {
      "autosomal dominant mode of inheritance": []
    },
    "type-counts": {}
  },
  {
    "qid": "530e0d6e5937551c09000001",
    "question": "List clinical trials that have directly compared microsurgical clipping with endovascular coiling for treatment of ruptured brain aneurysms?",
    "answer-types": {
      "international subarachnoid aneurysmal trial (BRAT)": [],
      "FIAT study": [],
      "international subarachnoid aneurysmal trial": [],
      "Barrow Ruptured Aneurysm Trial": [],
      "Barrow Ruptured Aneurysm Trial (BRAT)": [],
      "BRAT": [
        "umls:prog"
      ]
    },
    "type-counts": {
      "umls:prog": 1
    }
  },
  {
    "qid": "530cf54dab4de4de0c000009",
    "question": "What is the reason for the narcolepsy cases developed after H1N1 influenza vaccination?",
    "answer-types": {
      "The proposed mechanism for postvaccination narcolepsy is one in which an environmental trigger causes or enhances an antibody-mediated autoimmune response in patients with a preexisting genetic susceptibility.": []
    },
    "type-counts": {}
  },
  {
    "qid": "5311bf53e3eabad021000006",
    "question": "Which are the biotracers used for detection of Alzheimer\u0027s disease using PET?",
    "answer-types": {
      "flute": [],
      "BAY 94-9172": [
        "umls:orch"
      ],
      "Florbetaben": [
        "umls:orch"
      ],
      "Florbetapir F 18": [
        "umls:elii",
        "umls:irda"
      ],
      "Pittsburgh compound B": [
        "umls:orch"
      ],
      "18F flutemetamol": [
        "umls:elii",
        "umls:irda",
        "umls:phsu"
      ],
      "Florbetapir F 18 (18F-AV-45)": [
        "umls:elii",
        "umls:irda"
      ],
      "18F flutemetamol (flute)": [
        "umls:elii",
        "umls:irda",
        "umls:phsu"
      ],
      "18F-AV-45": [
        "umls:orch",
        "umls:phsu"
      ],
      "Florbetaben (BAY 94-9172)": [
        "umls:orch"
      ]
    },
    "type-counts": {
      "umls:elii": 4,
      "umls:irda": 4,
      "umls:orch": 5,
      "umls:phsu": 3
    }
  },
  {
    "qid": "569e79ecceceede94d000002",
    "question": "What was the purpose of the FANTOM3 project?",
    "answer-types": {
      "The comprehensive characterization of the mouse transcriptome.": []
    },
    "type-counts": {}
  },
  {
    "qid": "515bd543298dcd4e51000001",
    "question": "In which isochores are Alu elements enriched?",
    "answer-types": {
      "H2": [
        "umls:bpoc"
      ],
      "H3": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bpoc": 1,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52e6c92598d0239505000019",
    "question": "Which are the mutational hotspots of the human KRAS oncogene?",
    "answer-types": {
      "Codon 61": [
        "umls:lbpr"
      ],
      "Codon 31": [],
      "Codon 18": [],
      "Codon 15": [
        "umls:gngm"
      ],
      "Codon 146": [
        "umls:lbpr"
      ],
      "Codon 13": [
        "umls:comd"
      ],
      "Codon 12": [
        "umls:comd"
      ]
    },
    "type-counts": {
      "umls:lbpr": 2,
      "umls:comd": 2,
      "umls:gngm": 1
    }
  },
  {
    "qid": "57279ef20fd6f91b68000018",
    "question": "Which intraflagellar transport (IFT) motor protein has been linked to human skeletal ciliopathies?",
    "answer-types": {
      "Intraflagellar transport": [
        "umls:celf"
      ],
      "IFT": [
        "umls:celf"
      ],
      "Intraflagellar transport (IFT) motor protein DYNC2H1": [
        "umls:celf"
      ]
    },
    "type-counts": {
      "umls:celf": 3
    }
  },
  {
    "qid": "56a8d660a17756b72f000006",
    "question": "What is the link between Nonidet-40 (NP-40) and biotinylation?",
    "answer-types": {
      "Reduction of contamination by endogenous biotinylated carboxylases during purification of biotin tagged nuclear proteins.": []
    },
    "type-counts": {}
  },
  {
    "qid": "5353aedb288f4dae47000006",
    "question": "Which is the transcript responsible for X-chromosome inactivation?",
    "answer-types": {
      "Xist": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "56c83f365795f9a73e000011",
    "question": "Which domain allowing self-association do exist in TDP-43 and FUS proteins?",
    "answer-types": {
      "Prion-like domain": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "531778ddb166e2b80600000f",
    "question": "Which are the Chompret criteria for Li-Fraumeni syndrome?",
    "answer-types": {
      "ACC": [
        "umls:bpoc"
      ],
      "All families with a p53 mutation must have at least one family member with a sarcoma, breast, brain, or adrenocortical carcinoma": [],
      "All families with a p53 mutation must have at least one family member with a sarcoma, breast, brain, or adrenocortical carcinoma (ACC).": [],
      "Any patient with adrenocortical cancer (ACC), irrespective of age and family history.": [],
      "Any patient with adrenocortical cancer": []
    },
    "type-counts": {
      "umls:bpoc": 1
    }
  },
  {
    "qid": "56d042ae3975bb303a00000d",
    "question": "When ceritinib used instead of crizotinib?",
    "answer-types": {
      "crizotinib-naïve ALK-positive metastatic NSCLC patients": [],
      "crizotinib-resistant ALK-positive metastatic NSCLC patients": []
    },
    "type-counts": {}
  },
  {
    "qid": "52bf1f1303868f1b06000014",
    "question": "What type of enzyme is peroxiredoxin 2 (PRDX2)?",
    "answer-types": {
      "antioxidant": [
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:phsu": 1
    }
  },
  {
    "qid": "52fb42752059c6d71c00005e",
    "question": "Which are the thyroid hormone analogs utilized in human studies?",
    "answer-types": {
      "TRIAC": [
        "umls:orch",
        "umls:phsu"
      ],
      "TETRAC": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "56be0e4aef6e394741000008",
    "question": "List Kartagener Syndrome Triad.",
    "answer-types": {
      "sinusitis": [
        "umls:dsyn"
      ],
      "bronchiectasis": [
        "umls:dsyn"
      ],
      "situs inversus": [
        "umls:cgab"
      ]
    },
    "type-counts": {
      "umls:cgab": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "550f0e4c6a8cde6b72000003",
    "question": "Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?",
    "answer-types": {
      "Facioscapulohumeral dystrophy": [
        "umls:dsyn"
      ],
      "FSHD": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 2
    }
  },
  {
    "qid": "5319ac36b166e2b806000031",
    "question": "Which G protein is essential in the formation and function of lamellipodia?",
    "answer-types": {
      "Rac1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "54dfc6501388e8454a000009",
    "question": "Which are the main functions of the APOBEC3 family of proteins?",
    "answer-types": {
      "host-mediated defense against exogenous viruses": [],
      "defense against endogenous transposable elements": []
    },
    "type-counts": {}
  },
  {
    "qid": "52e0c9a298d0239505000010",
    "question": "Which histone modifications are associated with constitutive heterochromatin?",
    "answer-types": {
      "H3K9Me2": [],
      "H4K20me3": [
        "umls:moft"
      ],
      "H3K9Me1": [],
      "H3K9me3": [],
      "H3S10": [
        "umls:moft"
      ],
      "H3K79me3": [],
      "H3K27me2": [
        "umls:aapp"
      ],
      "H3K27me1": []
    },
    "type-counts": {
      "umls:moft": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "530cf54dab4de4de0c00000c",
    "question": "What is the main application of SWATH-MS in proteomics?",
    "answer-types": {
      "The identification and quantification of any protein.": []
    },
    "type-counts": {}
  },
  {
    "qid": "52bf217003868f1b0600001b",
    "question": "What can Nothobranchius furzeri be used as a model system for?",
    "answer-types": {
      "aging research": []
    },
    "type-counts": {}
  },
  {
    "qid": "54f2228e64850a5854000002",
    "question": "Which is the mass-tag that reveal the ubiquitination of a lysine residue?",
    "answer-types": {
      "Lys-ɛ-Gly-Gly (K-ɛ-GG) is the remnant produced by trypsin digestion of proteins having ubiquitinated lysine side chains.": [],
      "K-ɛ-GG": [],
      "Lys-ɛ-Gly-Gly": []
    },
    "type-counts": {}
  },
  {
    "qid": "5323640b9b2d7acc7e000014",
    "question": "Which gene is involved in CADASIL?",
    "answer-types": {
      "Notch3 gene": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "51487ef9d24251bc05000031",
    "question": "Which two catechol-O-methyl transferase (COMT) inhibitors can be used for treatment of Parkinson disease?",
    "answer-types": {
      "tolcapone": [
        "umls:orch",
        "umls:phsu"
      ],
      "entacapone": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "5505db6a8e1671127b000003",
    "question": "What are the structures formed when keratin molecules come together?",
    "answer-types": {
      "Intermediate filaments": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "531d1998267d7dd053000001",
    "question": "Which is the prognostic impact of hypothyroidism in patients with acute myocardial infarction?",
    "answer-types": {
      "Low T3 Syndrome isassociatedwithpoor prognosis in patients with acute myocardial infarction": []
    },
    "type-counts": {}
  },
  {
    "qid": "54c225bcf693c3b16b000002",
    "question": "Mutations of which genes have been associated with Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)?",
    "answer-types": {
      "ryanodine receptor 2": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "RYR2": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "triadin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "calmodulin 1": [
        "umls:gngm"
      ],
      "potassium channel, inwardly rectifying subfamily J, member 2": [
        "umls:gngm"
      ],
      "calsequestrin 2": [
        "umls:gngm"
      ],
      "CASQ2": [
        "umls:gngm"
      ],
      "CALM1": [
        "umls:gngm"
      ],
      "KCNJ2": [
        "umls:gngm"
      ],
      "TRDN": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:rcpt": 2,
      "umls:gngm": 7,
      "umls:bacs": 1,
      "umls:aapp": 3
    }
  },
  {
    "qid": "532c0d7fd6d3ac6a3400001c",
    "question": "List programs suitable for pharmacophore modelling",
    "answer-types": {
      "MOE": [
        "umls:dsyn"
      ],
      "Pharmacophore Elucidation": [],
      "LigandScout program": [],
      "Molecular Operating Environment": [],
      "Molecular Operating Environment (MOE)": [],
      "HypoGen module": [],
      "PharmaGist": [],
      "Genetic Algorithm Similarity Program": [],
      "GASP": [
        "umls:sosy"
      ],
      "Discovery Studio program": [],
      "Genetic Algorithm Similarity Program (GASP)": [],
      "HipHop module": [],
      "Catalyst": [
        "umls:phpr"
      ],
      "3D QSAR Pharmacophore Generation module": []
    },
    "type-counts": {
      "umls:sosy": 1,
      "umls:dsyn": 1,
      "umls:phpr": 1
    }
  },
  {
    "qid": "530c844e970c65fa6b000014",
    "question": "List disorders that are caused by mutations in the mitochondrial MTND6 gene.",
    "answer-types": {
      "Leigh syndrome": [
        "umls:dsyn"
      ],
      "Leber\u0027s hereditary optic neuropathy and/or dystonia": []
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "571653aecb4ef8864c000005",
    "question": "Which are the most common methods for ctDNA (circulating tumour DNA) detection?",
    "answer-types": {
      "nanoplasmonics": [],
      "electrochemical sensors": [],
      "CAPP-Seq": [],
      "biosensors": [
        "umls:resd"
      ],
      "Cancer personalized profiling by deep sequencing": [],
      "liquid biopsy": [
        "umls:diap"
      ]
    },
    "type-counts": {
      "umls:resd": 1,
      "umls:diap": 1
    }
  },
  {
    "qid": "52bf1d2e03868f1b0600000c",
    "question": "Which gene is associated with Muenke syndrome?",
    "answer-types": {
      "Fibroblast Growth Factor Receptor 3": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "Fibroblast Growth Factor Receptor 3 (FGFR3)": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "FGFR3": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:rcpt": 3,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56bc77a3ac7ad10019000015",
    "question": "RTS S AS01 vaccine was developed to prevent which disease?",
    "answer-types": {
      "malaria": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "517a8bab8ed59a060a000040",
    "question": "Which deiodinases are best known to be present in brain?",
    "answer-types": {
      "Type 2 deiodinase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Type 3 deiodinase": []
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5149a61ed24251bc05000044",
    "question": "What are the computational methods for the prediction of beta-barrel transmembrane proteins?",
    "answer-types": {
      "BTMX": [],
      "BETAWARE": [],
      "TBBPred": [],
      "BBF": [
        "umls:euka"
      ],
      "TMB-Hunt": [],
      "TransFold": [],
      "beta-barrel finder": [],
      "PROFtmb": [],
      "HHomp": [],
      "TMBHMM": [],
      "OMBBpred": [],
      "BOCTOPUS": [],
      "BOMP": [
        "umls:topp"
      ],
      "TMBKNN": [],
      "TMBETA-NET": [],
      "Wimley": [],
      "TMBpro": [],
      "HMM-B2TMR": [],
      "PRED-TMBB": [],
      "Beta barrel TransMembrane eXposure": [],
      "TMBETAPRED-RBF": []
    },
    "type-counts": {
      "umls:euka": 1,
      "umls:topp": 1
    }
  },
  {
    "qid": "54cb9c94f693c3b16b000005",
    "question": "Which is the main regulatory molecule of SERCA2A function in the cardiac muscle?",
    "answer-types": {
      "PLN": [
        "umls:gngm"
      ],
      "plb": [
        "umls:gngm"
      ],
      "Phospholamban": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:gngm": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5519113b622b19434500000f",
    "question": "Which gene is responsible for the development of the Mowat-Wilson syndrome?",
    "answer-types": {
      "ZEB2": [
        "umls:gngm"
      ],
      "ZFHX1B": [
        "umls:gngm"
      ],
      "SIP-1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 3
    }
  },
  {
    "qid": "531d6bfc267d7dd053000007",
    "question": "How is active neurotoxin of Clostridium botulinum detected?",
    "answer-types": {
      "FDC (functional dual coating) microtitre plate immuno-biochemical assay": [
        "umls:dsyn"
      ],
      "mouse lethality assay": [],
      "FDC": [
        "umls:dsyn"
      ],
      "endopeptidase activity monitored via UV-Visible spectroscopy": [],
      "differentiated cell models": [],
      "by mass spectrometry": [
        "umls:mbrt"
      ],
      "bioassay": [
        "umls:lbpr"
      ],
      "peptide cleavage assay": [],
      "functional dual coating": []
    },
    "type-counts": {
      "umls:lbpr": 1,
      "umls:dsyn": 2,
      "umls:mbrt": 1
    }
  },
  {
    "qid": "56d19a363975bb303a000017",
    "question": "Which factor interacts with Treslin/TICRR throughout the cell cycle of human cells?",
    "answer-types": {
      "MDM two binding protein": [],
      "MTBP": [
        "umls:gngm"
      ],
      "MDM two binding protein (MTBP)": []
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "5149f494d24251bc0500004c",
    "question": "Which medication should be administered when managing patients with suspected acute opioid overdose?",
    "answer-types": {
      "naloxone": [
        "umls:orch"
      ]
    },
    "type-counts": {
      "umls:orch": 1
    }
  },
  {
    "qid": "56c33e5695c1e7cc5b000001",
    "question": "In which nuclear compartments is heterochromatin located?",
    "answer-types": {
      "pericentromeric heterochromatin": [],
      "perinucleolar heterochromatin": [],
      "peripheral heterochromatin": []
    },
    "type-counts": {}
  },
  {
    "qid": "5547a7e9f35db75526000006",
    "question": "Which enzymes are involved in global genome nucleotide excision repair (GG-NER) in bacteria?",
    "answer-types": {
      "PcrA helicase (instead of Uvrd, in gram-positive bacteria)": [],
      "UvrC nuclease": [],
      "Ligase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "instead of Uvrd, in gram-positive bacteria": [],
      "UvrA": [
        "umls:enzy",
        "umls:aapp"
      ],
      "UvrB": [
        "umls:celc"
      ],
      "PcrA helicase": [],
      "Cho nuclease": [],
      "DNA polymerase I": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Cho nuclease (instead of UvrC)": [],
      "UvrD 1A helicase": [],
      "instead of UvrC": []
    },
    "type-counts": {
      "umls:celc": 1,
      "umls:enzy": 3,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56cdf3e55795f9a73e00003c",
    "question": "Which type of GTPases is required for amino acid-dependent activation of mTORC1?",
    "answer-types": {
      "Heterodimeric Rag GTPases": []
    },
    "type-counts": {}
  },
  {
    "qid": "570921e4cf1c325851000017",
    "question": "In which genomic regions are Alu enriched?",
    "answer-types": {
      "gene conversion-prone regions": [],
      "genes which are involved in metabolism, transport, and signaling processes": []
    },
    "type-counts": {}
  },
  {
    "qid": "54df695b1388e8454a000004",
    "question": "What is the synonym of the lubag disease?",
    "answer-types": {
      "X-linked dystonia-parkinsonism": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "56bcdf1ad36b5da378000009",
    "question": "Dracorhodin perchlorate was tested for treatment of which cancers?",
    "answer-types": {
      "prostate cancer": [
        "umls:neop"
      ],
      "melanoma": [
        "umls:neop"
      ],
      "premyelocytic leukemia": [],
      "gastric tumor": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 3
    }
  },
  {
    "qid": "51724fca8ed59a060a000013",
    "question": "Which is the execution time (complexity) of the Smith-Waterman algorithm for the alignment of two sequences",
    "answer-types": {
      "quadratic": [
        "umls:qnco"
      ]
    },
    "type-counts": {
      "umls:qnco": 1
    }
  },
  {
    "qid": "56bcc455d36b5da378000003",
    "question": "List mutations that are implicated in the Gray Platelet Syndrome.",
    "answer-types": {
      "GFI1B": [
        "umls:gngm"
      ],
      "NBEAL2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 2
    }
  },
  {
    "qid": "5506c3e38e1671127b00000a",
    "question": "The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?",
    "answer-types": {
      "NCX": [
        "umls:gngm"
      ],
      "Na(+)/Ca(2+) exchanger": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54fc4e2e6ea36a810c000003",
    "question": "What is Piebaldism?",
    "answer-types": {
      "Piebaldism is a rare autosomal dominant disorder of melanocyte development characterized by a congenital white forelock and multiple symmetrical stable hypopigmented or depigmented macules.": []
    },
    "type-counts": {}
  },
  {
    "qid": "56d85e7751531f7e33000001",
    "question": "Which SLC family is FLVCR1 a member of?",
    "answer-types": {
      "SLC49": []
    },
    "type-counts": {}
  },
  {
    "qid": "56e47e0051531f7e3300001c",
    "question": "Where are the orexigenic peptides synthesized?",
    "answer-types": {
      "The orexigenic peptides are sythesized in the hypothalamus.": []
    },
    "type-counts": {}
  },
  {
    "qid": "5721f4b30fd6f91b68000011",
    "question": "Which inherited disorder is known to be caused by mutations in the NEMO gene?",
    "answer-types": {
      "Incontinentia pigmenti or Bloch-Sulzberger syndrome": []
    },
    "type-counts": {}
  },
  {
    "qid": "52f89fd32059c6d71c000051",
    "question": "List interaction partners for the protein GATA1.",
    "answer-types": {
      "MeCP1": [
        "umls:gngm"
      ],
      "EKLF": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Gfi-1b": [
        "umls:bacs",
        "umls:aapp"
      ],
      "PIAS3": [
        "umls:gngm"
      ],
      "Ldb1": [
        "umls:gngm"
      ],
      "LMO2-C": [],
      "PU.1": [
        "umls:gngm"
      ],
      "RUNX1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Ski": [
        "umls:blor"
      ],
      "SP1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "ACF/WCRF complex": [],
      "CBP/p300": [
        "umls:bacs",
        "umls:aapp"
      ],
      "FOG-1": [
        "umls:aapp"
      ],
      "TAL-1": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:blor": 1,
      "umls:bacs": 6,
      "umls:gngm": 4,
      "umls:aapp": 7
    }
  },
  {
    "qid": "533675ced6d3ac6a34000056",
    "question": "What histone variants play a role in the DNA damage reponse?",
    "answer-types": {
      "H1R": [
        "umls:gngm"
      ],
      "H2A.Z": [
        "umls:gngm"
      ],
      "H2A.X": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52f895602059c6d71c000040",
    "question": "List tele monitoring applications of miniaturised sensors",
    "answer-types": {
      "vital signs": [
        "umls:hlca"
      ],
      "Temperature": [
        "umls:orga"
      ],
      "Blood pressure control": [
        "umls:topp"
      ],
      "Step-counting": [],
      "Body weight": [
        "umls:orga"
      ],
      "uterine contractions": [
        "umls:ortf"
      ],
      "ECG": [
        "umls:fndg"
      ],
      "fetal heart signal": [
        "umls:hlca"
      ],
      "Oxygen saturation": [
        "umls:moft"
      ],
      "Falls detector": [],
      "Sleep monitoring": [
        "umls:diap"
      ],
      "Electrocardiograms": [
        "umls:fndg"
      ],
      "breath rate": [
        "umls:clna"
      ],
      "SaO2": [
        "umls:ortf"
      ],
      "Heart failure control": [
        "umls:clna"
      ]
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:clna": 2,
      "umls:moft": 1,
      "umls:orga": 2,
      "umls:diap": 1,
      "umls:ortf": 2,
      "umls:topp": 1,
      "umls:hlca": 2
    }
  },
  {
    "qid": "553c9f96f32186855800000c",
    "question": "How are ultraconserved elements called when they form clusters?",
    "answer-types": {
      "gene regulatory blocks (GRBs)": [],
      "gene regulatory blocks": [],
      "GRBs": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "56cf36263975bb303a000007",
    "question": "Which disease has been associated to a disruptive ALX1 protein?",
    "answer-types": {
      "frontonasal dysplasia": [
        "umls:cgab"
      ]
    },
    "type-counts": {
      "umls:cgab": 1
    }
  },
  {
    "qid": "517170c48ed59a060a00000d",
    "question": "How many selenoproteins are encoded in the human genome?",
    "answer-types": {
      "25": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "534eb34b288f4dae47000002",
    "question": "In which process Src, Cortactin and MT1-MMP are playing an essential role?",
    "answer-types": {
      "Src, Cortactin and MT1-MMP play an essential role in the formation and function of invadopodia.": []
    },
    "type-counts": {}
  },
  {
    "qid": "5710e131a5ed216440000001",
    "question": "In which yeast chromosome does the rDNA cluster reside?",
    "answer-types": {
      "chromosome XII": [],
      "chromosome 12": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "56e2acfe51531f7e33000014",
    "question": "During which stage of the cell cycle is cohesin deposited on the yeast genome?",
    "answer-types": {
      "S-phase": [
        "umls:tmco"
      ]
    },
    "type-counts": {
      "umls:tmco": 1
    }
  },
  {
    "qid": "517818508ed59a060a000035",
    "question": "Which is the neurodevelopmental disorder associated to mutations in the X- linked gene mecp2?",
    "answer-types": {
      "Rett syndrome": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "56a8ee75a17756b72f000007",
    "question": "What is the link between Dax1 and Esrrb?",
    "answer-types": {
      "Dax1 associates with Esrrb and regulates its function in embryonic stem cells.": []
    },
    "type-counts": {}
  },
  {
    "qid": "56d04a533975bb303a000010",
    "question": "What is dovitinib?",
    "answer-types": {
      "tyrosine kinase receptor inhibitor": [
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:phsu": 1
    }
  },
  {
    "qid": "551829a76487737b43000009",
    "question": "List the diseases for which there are point-of-care breath tests",
    "answer-types": {
      "lung cancer": [
        "umls:neop"
      ],
      "respiratory distress syndrome": [
        "umls:dsyn"
      ],
      "heart failure": [
        "umls:dsyn"
      ],
      "methanol intoxication": [],
      "Helicobacter pylori infection": [
        "umls:dsyn"
      ],
      "kidney diseases": [
        "umls:dsyn"
      ],
      "tuberculosis": [
        "umls:dsyn"
      ],
      "asthma": [
        "umls:dsyn"
      ],
      "liver diseases": [
        "umls:dsyn"
      ],
      "pulmonary embolism": [
        "umls:dsyn"
      ],
      "diabetes": [
        "umls:dsyn"
      ],
      "sepsis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:neop": 1,
      "umls:dsyn": 10
    }
  },
  {
    "qid": "534abe8aaeec6fbd07000013",
    "question": "Which heat shock protein is found to be upregulated during Hsp90 inhibition?",
    "answer-types": {
      "HSP70": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "571f33bd0fd6f91b68000003",
    "question": "Which gene is responsible for the development of Sotos syndrome?",
    "answer-types": {
      "NSD1 gene": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "53617eeb7d100faa0900000a",
    "question": "What is the name for anorexia in gymnasts?",
    "answer-types": {
      "Anorexia Athletica": []
    },
    "type-counts": {}
  },
  {
    "qid": "52bf209303868f1b0600001a",
    "question": "What are the indications for alteplase?",
    "answer-types": {
      "Arterial Thrombotic Occlusion": [
        "umls:patf"
      ],
      "Pulmonary Thromboembolism": [
        "umls:dsyn"
      ],
      "myocardial infarction": [
        "umls:dsyn"
      ],
      "central venous catheter (CVC) occlusions": [
        "umls:topp"
      ],
      "central venous catheter": [
        "umls:medd"
      ],
      "acute pulmonary embolism": [
        "umls:dsyn"
      ],
      "Acute Myocardial Infarction": [
        "umls:dsyn"
      ],
      "CVC": [
        "umls:medd"
      ],
      "deep vein thrombosis": [
        "umls:dsyn"
      ],
      "limb artery occlusions": [],
      "thrombolysis": [
        "umls:clna"
      ],
      "Vein Thrombosis": [
        "umls:patf"
      ],
      "Ischaemic Stroke": [
        "umls:dsyn"
      ],
      "MI": [
        "umls:geoa"
      ],
      "AMI": [
        "umls:dsyn"
      ],
      "ischemic stroke": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:clna": 1,
      "umls:patf": 2,
      "umls:medd": 2,
      "umls:topp": 1,
      "umls:dsyn": 8,
      "umls:geoa": 1
    }
  },
  {
    "qid": "55152bd246478f2f2c000002",
    "question": "List scaffold proteins of the ERK signaling pathway.",
    "answer-types": {
      "14-3-3": [
        "umls:bacs",
        "umls:aapp"
      ],
      "MP-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "IQ motif-containing GTPase-activating protein 1": [
        "umls:gngm"
      ],
      "beta-arrestin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "hDlg": [
        "umls:gngm"
      ],
      "mitogen-activated protein kinase organizer 1": [
        "umls:gngm"
      ],
      "IQGAP1": [
        "umls:gngm"
      ],
      "KSR": [
        "umls:gngm"
      ],
      "kinase suppressor of Ras": [
        "umls:enzy",
        "umls:aapp"
      ],
      "MEK partner-1": [
        "umls:gngm"
      ],
      "caveolin-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Human disc-large homolog": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Sef": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:gngm": 7,
      "umls:bacs": 5,
      "umls:aapp": 6
    }
  },
  {
    "qid": "516c3960298dcd4e51000073",
    "question": "Which are the families of mammalian DNA-(cytosine-5)-methyltransferases?",
    "answer-types": {
      "DNMT3": [
        "umls:amas"
      ],
      "DNMT1": [
        "umls:gngm"
      ],
      "DNMT2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:amas": 1,
      "umls:gngm": 2
    }
  },
  {
    "qid": "54e0ac041388e8454a00000f",
    "question": "Which classes of endogenous retroelements are known to date?",
    "answer-types": {
      "Long Terminal Repeats": [
        "umls:nnon"
      ],
      "retrotransposons containing LTRs": [],
      "retrostransposons lacking LTRs (Long Terminal Repeats)": [],
      "retrostransposons lacking LTRs": [],
      "retrotransposons containing LTRs (Long Terminal Repeats)": []
    },
    "type-counts": {
      "umls:nnon": 1
    }
  },
  {
    "qid": "553a7a59f321868558000002",
    "question": "List GATA-1 interacting partners as discovered with the help of the biotinylation tagging approach.",
    "answer-types": {
      "Gfi-1b": [
        "umls:bacs",
        "umls:aapp"
      ],
      "fog-1": [
        "umls:aapp"
      ],
      "tal-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "ACF/WCRF complex": [],
      "MeCP1 complex": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1,
      "umls:bacs": 2,
      "umls:aapp": 3
    }
  },
  {
    "qid": "52f129d92059c6d71c000009",
    "question": "Which diseases are associated with Alu element insertion?",
    "answer-types": {
      "HNPCC": [
        "umls:neop"
      ],
      "myotonic dystrophy type 2": [
        "umls:dsyn"
      ],
      "anterior pituitary aplasia": [
        "umls:fndg"
      ],
      "autosomal dominant optic atrophy": [
        "umls:dsyn"
      ],
      "FAP": [
        "umls:neop"
      ],
      "HIGM": [
        "umls:dsyn"
      ],
      "hyper-IgM with immunodeficiency syndrome (HIGM)": [
        "umls:dsyn"
      ],
      "Friedreich ataxia": [
        "umls:dsyn"
      ],
      "hyper-IgM with immunodeficiency syndrome": [
        "umls:dsyn"
      ],
      "spinocerebellar ataxia type 10": [
        "umls:dsyn"
      ],
      "Menkes disease": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:neop": 2,
      "umls:dsyn": 8
    }
  },
  {
    "qid": "534e364e288f4dae47000001",
    "question": "Approximately how many recombination hotspots have been found in the yeast genome?",
    "answer-types": {
      "200": [
        "_QUANTITY"
      ],
      "~200": [
        "_QUANTITY"
      ],
      "Approximately 200": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 3
    }
  },
  {
    "qid": "533ea8fcc45e133714000010",
    "question": "What is the name of the stem loop present in the 3\u0027 end of genes encoding for selenoproteins?",
    "answer-types": {
      "SECIS": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "55192f20622b194345000014",
    "question": "Which proteins are the different members of the NF-kappaB family of transcription factors?",
    "answer-types": {
      "c-Rel": [
        "umls:gngm"
      ],
      "NF-kB2/p52": [],
      "NF-kB1/p50": [],
      "RelA": [
        "umls:gngm"
      ],
      "p65": [
        "umls:bacs",
        "umls:aapp"
      ],
      "RelB": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 3,
      "umls:aapp": 1
    }
  },
  {
    "qid": "571e417bbb137a4b0c00000a",
    "question": "What are the symptoms of Rotor syndrome?",
    "answer-types": {
      "near-absent hepatic uptake of anionic diagnostics": [],
      "coproporphyrinuria": [
        "umls:dsyn"
      ],
      "conjugated hyperbilirubinemia": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 2
    }
  },
  {
    "qid": "52fa73e82059c6d71c000059",
    "question": "List the existing methods for genetic manipulation of cells.",
    "answer-types": {
      "transformation-competent artificial chromosome": [],
      "BACs": [
        "umls:inpr"
      ],
      "direct delivery methods": [],
      "Agrobacterium-mediated delivery": [],
      "direct in vitro transposition of viral genomes with a BAC cassette, and subsequent recovery in Escherichia coli": [],
      "TAC": [
        "umls:diap"
      ],
      "methods using plant artificial chromosomes": [],
      "combined use of Red/ET recombination and unique restriction site elimination": [],
      "Bacterial artificial chromosomes": [
        "umls:resd"
      ],
      "site-directed plasmid mutagenesis": [],
      "Bacterial artificial chromosomes (BACs)": [
        "umls:resd"
      ],
      "transformation-competent artificial chromosome (TAC)-based acceptor vector, by exploiting the CreloxP recombination system and homing endonucleases": []
    },
    "type-counts": {
      "umls:resd": 2,
      "umls:inpr": 1,
      "umls:diap": 1
    }
  },
  {
    "qid": "54edf81f94afd61504000014",
    "question": "Which SWI/SNF protein complex subunit has been demonstrated to interact with the FANCA gene product?",
    "answer-types": {
      "BRG1": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "554397f6ed966d112c00000c",
    "question": "List representatives of the major fungal hypoxanthine-adenine-guanine transporter families.",
    "answer-types": {
      "Fcy21p": [],
      "AzgA": []
    },
    "type-counts": {}
  },
  {
    "qid": "551910d3622b194345000008",
    "question": "Which proteins have been identified as RET ligands?",
    "answer-types": {
      "persephin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "GDNF": [
        "umls:bacs",
        "umls:aapp"
      ],
      "PSPN": [
        "umls:gngm"
      ],
      "ARTN": [
        "umls:gngm"
      ],
      "artemin": [
        "umls:gngm"
      ],
      "glial cell-line-derived neurotrophic factor": [
        "umls:bacs",
        "umls:aapp"
      ],
      "NTN": [
        "umls:gngm"
      ],
      "neurturin": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:gngm": 4,
      "umls:bacs": 4,
      "umls:aapp": 4
    }
  },
  {
    "qid": "5314b20bdae131f847000005",
    "question": "Which substances are dangerous to g6PD deficient individuals?",
    "answer-types": {
      "chloroquine": [
        "umls:orch",
        "umls:phsu"
      ],
      "primaquine": [
        "umls:orch",
        "umls:phsu"
      ],
      "pamaquine": [
        "umls:orch",
        "umls:phsu"
      ],
      "sulfonamides": [
        "umls:orch"
      ],
      "antibiotics": [
        "umls:antb"
      ],
      "henna": [
        "umls:orch",
        "umls:phsu"
      ],
      "fava beans": [
        "umls:plnt"
      ]
    },
    "type-counts": {
      "umls:antb": 1,
      "umls:plnt": 1,
      "umls:orch": 5,
      "umls:phsu": 4
    }
  },
  {
    "qid": "52ef7786c8da898910000015",
    "question": "Do archaeal genomes contain one or multiple origins of replication?",
    "answer-types": {
      "Multiple": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "52fb78d82059c6d71c000068",
    "question": "Which mutations of SCN5A gene are implicated in Brugada syndrome?",
    "answer-types": {
      "8x": [
        "umls:orch"
      ],
      "N1443S": [],
      "p.R965C": [],
      "c.664C\u003eT; p.Arg222X": [],
      "p.1876insM": [],
      "H558R": [],
      "E1784K": [],
      "R1232W/T1620M": [],
      "R1192Q": [],
      "E1152X": [],
      "G1408R": [],
      "G1743R": [],
      "W822X": [],
      "D1795": [],
      "G400A": [],
      "V728I": [],
      "11x": [
        "umls:bact"
      ],
      "Val1340\u003eIle": [],
      "K1527R": [],
      "E1784K (14x)": [],
      "F861WfsX90": [],
      "A1569P": [],
      "Ala735\u003eThr": [],
      "7x": [
        "umls:bacs",
        "umls:phsu"
      ],
      "D356N (8x)": [],
      "delF1617": [],
      "Q55X": [],
      "F861WfsX90 (11x)": [],
      "D356N": [],
      "p.W1095X, c.3284G\u003eA": [],
      "Ala2\u003eThr, Ala735": [],
      "V95I": [],
      "E901K": [],
      "c.4810+3_4810+6dupGGGT": [],
      "A735V": [],
      "14x": [
        "umls:bact"
      ],
      "R27H": [],
      "I137M": [],
      "G1408R (7x)": [],
      "IVS18-1G\u003eA": [],
      "R367H": [],
      "A1649V": [],
      "p.I848fs": []
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:bacs": 1,
      "umls:phsu": 1,
      "umls:bact": 2
    }
  },
  {
    "qid": "535d5bac7d100faa09000001",
    "question": "List all articles on network meta-analysis for smoking cessation",
    "answer-types": {
      "Effectiveness and cost-effectiveness of computer and other electronic aids for smoking cessation: a systematic review and network meta-analysis.": [],
      "Smoking cessation interventions in COPD: a network meta-analysis of randomised trials.": [],
      "Pharmacological interventions for smoking cessation: an overview and network meta-analysis": [],
      "Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis.": []
    },
    "type-counts": {}
  },
  {
    "qid": "55200c606b348bb82c000013",
    "question": "Which clotting factor is inhibited by betrixaban?",
    "answer-types": {
      "Xa": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "55031270e9bde6963400001a",
    "question": "Which are the most frequent syndromes associated with inherited bone marrow failure?",
    "answer-types": {
      "Diamond-Blackfan anemia": [
        "umls:dsyn"
      ],
      "Shwachman-Diamond syndrome": [
        "umls:dsyn"
      ],
      "Fanconi anemia": [
        "umls:dsyn"
      ],
      "Dyskeratosis congenita": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 4
    }
  },
  {
    "qid": "56a8b8b5a17756b72f000005",
    "question": "What is the outcome of TAF10 interacting with the GATA1 transcription factor?",
    "answer-types": {
      "Control of Mouse Erythropoiesis": []
    },
    "type-counts": {}
  },
  {
    "qid": "56d2ac03f22319765a000004",
    "question": "Which ones are the ESKAPE organisms?",
    "answer-types": {
      "Enterococcus faecium": [
        "umls:bact"
      ],
      "Acinetobacter baumannii": [
        "umls:bact"
      ],
      "Pseudomonas aeruginosa": [
        "umls:bact"
      ],
      "Staphylococcus aureus": [
        "umls:bact"
      ],
      "Enterobacter species": [
        "umls:bact"
      ],
      "Klebsiella pneumoniae": [
        "umls:bact"
      ]
    },
    "type-counts": {
      "umls:bact": 6
    }
  },
  {
    "qid": "5324bdba9b2d7acc7e00001a",
    "question": "How is bladder wall thickness measured?",
    "answer-types": {
      "Ultrasound": [
        "umls:diap"
      ]
    },
    "type-counts": {
      "umls:diap": 1
    }
  },
  {
    "qid": "54f35ad864850a5854000004",
    "question": "LY450139 is investigational name of which drug?",
    "answer-types": {
      "semagacestat": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "5727ab040fd6f91b68000019",
    "question": "Which gene has been found to be mutant in Lesch-Nyhan Disease patients?",
    "answer-types": {
      "Hypoxanthine guanine phosphoribosyl transferase": [
        "umls:dsyn"
      ],
      "Hypoxanthine guanine phosphoribosyl transferase (HPRT) gene": [
        "umls:dsyn"
      ],
      "HPRT": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:dsyn": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "516e7fda298dcd4e51000081",
    "question": "Which is the methyl donor of histone methyltransferases?",
    "answer-types": {
      "adenosylmethionine": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "S-adenosyl-L–methionine": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "SAM": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "S-Adenosylmethionine": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "AdoMet": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "S-Adenosyl methionine": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:bacs": 6,
      "umls:phsu": 6,
      "umls:aapp": 6
    }
  },
  {
    "qid": "515870cdd24251bc0500008f",
    "question": "Carbapenemase-producing gram-negative bacteria is a major health concern because their resistance to antibiotics. List the most frequent carbapenemases found in Enterobacteriaceae.",
    "answer-types": {
      "GES": [
        "umls:gngm"
      ],
      "IMI": [
        "umls:dsyn"
      ],
      "NMC": [
        "umls:bacs"
      ],
      "MBL": [
        "umls:aapp",
        "umls:phsu"
      ],
      "NDM": [
        "umls:enzy",
        "umls:aapp"
      ],
      "SME": [
        "umls:orch",
        "umls:phsu"
      ],
      "VIM": [
        "umls:gngm"
      ],
      "OXA-48": [
        "umls:enzy",
        "umls:aapp"
      ],
      "IMP": [
        "umls:nnon",
        "umls:bacs"
      ],
      "KPC": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:enzy": 2,
      "umls:orch": 1,
      "umls:dsyn": 2,
      "umls:bacs": 2,
      "umls:gngm": 2,
      "umls:phsu": 2,
      "umls:aapp": 3
    }
  },
  {
    "qid": "5171438a8ed59a060a000007",
    "question": "What is the gene frequently mutated in Multiple endocrine neoplasia 2 (MEN2) and Hisrchsprung disease?",
    "answer-types": {
      "Ret": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 1
    }
  },
  {
    "qid": "52f4f1d62059c6d71c00001c",
    "question": "Which are the clinical characteristics of isolated Non-compaction cardiomyopathy?",
    "answer-types": {
      "heart failure": [
        "umls:dsyn"
      ],
      "ventricular arrhythmias": [
        "umls:dsyn"
      ],
      "complete left branch conductive block": [],
      "paroxysmal supraventricular tachycardia": [
        "umls:dsyn"
      ],
      "excessively thickened endocardial layer with deep intertrabecular recesses": [],
      "syncope": [
        "umls:sosy"
      ],
      "stroke": [
        "umls:dsyn"
      ],
      "ratio of non-compacted to compacted myocardium \u003e2": [],
      "sick sinus syndrome": [
        "umls:dsyn"
      ],
      "Pulmonary hypertension": [
        "umls:patf"
      ]
    },
    "type-counts": {
      "umls:sosy": 1,
      "umls:patf": 1,
      "umls:dsyn": 5
    }
  },
  {
    "qid": "533c384dc45e133714000006",
    "question": "In which genomic positions is the histone variant macroH2A enriched?",
    "answer-types": {
      "Repressed regions": [],
      "Centromeres": [
        "umls:celc"
      ],
      "Inactive X chromosome": []
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "56ffd08bcf1c325851000009",
    "question": "From which sequence does the Alu repeat originate from?",
    "answer-types": {
      "7SL RNA": [
        "umls:nnon",
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5313058de3eabad02100000e",
    "question": "Abnormality in which vertebral region is important in the Bertolotti\u0027s syndrome?",
    "answer-types": {
      "lumbosacral": [
        "umls:spco"
      ]
    },
    "type-counts": {
      "umls:spco": 1
    }
  },
  {
    "qid": "5348307daeec6fbd07000011",
    "question": "What does iBAQ stand for in proteomic analysis?",
    "answer-types": {
      "intensity-based absolute quantification": []
    },
    "type-counts": {}
  },
  {
    "qid": "54da32bc0f63c58e6e000001",
    "question": "Which is the main target of the anti-arrhythmic activity of flecainide?",
    "answer-types": {
      "The sodium channel": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54d8ea2c4b1fd0d33c000002",
    "question": "Which is the most prevalent form of arrhythmia worldwide?",
    "answer-types": {
      "atrial fibrilation": [],
      "AF": [
        "umls:geoa"
      ]
    },
    "type-counts": {
      "umls:geoa": 1
    }
  },
  {
    "qid": "54e071e11388e8454a00000d",
    "question": "Which agents are included in the FLAMSA chemotherapy regimen?",
    "answer-types": {
      "cytarabine": [
        "umls:nnon",
        "umls:phsu"
      ],
      "fludarabine": [
        "umls:nnon",
        "umls:phsu"
      ],
      "amsacrine": [
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        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:nnon": 2,
      "umls:orch": 1,
      "umls:phsu": 3
    }
  },
  {
    "qid": "5506e2ff8e1671127b00000d",
    "question": "Which are the subunits of the IkB protein kinase (IKK)?",
    "answer-types": {
      "IKKgamma": [],
      "IKKγ": [],
      "IKKbeta": [
        "umls:bacs",
        "umls:aapp"
      ],
      "IKKα": [],
      "IKK1": [
        "umls:gngm"
      ],
      "IKKβ": [],
      "IKK2": [
        "umls:gngm"
      ],
      "IKKalpha": [
        "umls:celc"
      ],
      "NEMO": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:celc": 1,
      "umls:gngm": 3,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "53189b05b166e2b80600001e",
    "question": "Which glands are subject to attack by lymphocytes in Sjogren\u0027s syndrome?",
    "answer-types": {
      "The lacrimal and/or salivary glands": [
        "umls:cgab"
      ]
    },
    "type-counts": {
      "umls:cgab": 1
    }
  },
  {
    "qid": "51716a438ed59a060a00000a",
    "question": "Name five popular computer programs used to identify genes in genomic sequences",
    "answer-types": {
      "Glimmer": [
        "umls:sbst"
      ],
      "GeneID": [
        "umls:inpr"
      ],
      "Genscan": [],
      "Fgenesh": [],
      "Augustus": [
        "umls:fngs"
      ]
    },
    "type-counts": {
      "umls:inpr": 1,
      "umls:sbst": 1,
      "umls:fngs": 1
    }
  },
  {
    "qid": "514168ab23fec9037500000a",
    "question": "Which are the major transcription factors regulating glycolysis in mammals?",
    "answer-types": {
      "NF-κB": [
        "umls:imft",
        "umls:aapp"
      ],
      "Oct1": [
        "umls:gngm"
      ],
      "c-Myc": [
        "umls:gngm"
      ],
      "Src": [
        "umls:gngm"
      ],
      "STAT3": [
        "umls:bacs",
        "umls:aapp"
      ],
      "SIRT6": [
        "umls:gngm"
      ],
      "HNF4-alpha": [
        "umls:gngm"
      ],
      "HIF1-alpha": [
        "umls:gngm"
      ],
      "PVHL": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:imft": 1,
      "umls:bacs": 1,
      "umls:gngm": 6,
      "umls:aapp": 3
    }
  },
  {
    "qid": "51542e44d24251bc05000081",
    "question": "Mutations in which gene determine response to both erlotinib and gefitinib?",
    "answer-types": {
      "epidermal growth factor receptor": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "epidermal growth factor receptor (EGFR) gene": [
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        "umls:rcpt",
        "umls:aapp"
      ],
      "EGFR": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 3,
      "umls:rcpt": 3,
      "umls:aapp": 3
    }
  },
  {
    "qid": "53215fca9b2d7acc7e000005",
    "question": "Which protein complexes contain mitofilin?",
    "answer-types": {
      "mitochondrial inter-membrane space bridging complex": [],
      "MitOS": [
        "umls:celf"
      ],
      "mitochondrial inner membrane organizing system": [
        "umls:gngm"
      ],
      "MIB": [
        "umls:gngm"
      ],
      "MINOS": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:celf": 1,
      "umls:enzy": 1,
      "umls:gngm": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5148e1d6d24251bc0500003a",
    "question": "Mutation of which gene and which chromosome cause Neurofibromatosis type I?",
    "answer-types": {
      "NF1 gene": [
        "umls:gngm"
      ],
      "chromosome 17": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1,
      "umls:gngm": 1
    }
  },
  {
    "qid": "515c4f05298dcd4e51000006",
    "question": "Which genes does thyroid hormone receptor alpha1 regulate in the heart?",
    "answer-types": {
      "HCN4": [
        "umls:gngm"
      ],
      "β-myosin heavy chain": [],
      "KCNE1": [
        "umls:gngm"
      ],
      "KCND2": [
        "umls:gngm"
      ],
      "KCND3": [
        "umls:gngm"
      ],
      "SR(Ca)ATPase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "alpha-myosin heavy chain": [
        "umls:gngm"
      ],
      "KCNA4": [
        "umls:gngm"
      ],
      "nucleotide-gated potassium channel 2": [
        "umls:gngm"
      ],
      "phospholamban": [
        "umls:enzy",
        "umls:aapp"
      ],
      "HCN2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:gngm": 8,
      "umls:aapp": 2
    }
  },
  {
    "qid": "54d662113706e8952800000d",
    "question": "What is the content of the METLIN database?",
    "answer-types": {
      "METLIN is a metabolite database containing tandem mass spectrometry data for each metabolite.": []
    },
    "type-counts": {}
  },
  {
    "qid": "550739cf3b8a5dc045000002",
    "question": "Which is the RNA sequence of the canonical polyadenylation signal?",
    "answer-types": {
      "AAUAAA": [
        "umls:nnon",
        "umls:bacs"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:bacs": 1
    }
  },
  {
    "qid": "56ae40110a360a5e45000009",
    "question": "Which computational frameworks are available for predicting enhancers?",
    "answer-types": {
      "DEEP": [
        "umls:spco"
      ],
      "PRISM": [
        "umls:inpr"
      ]
    },
    "type-counts": {
      "umls:inpr": 1,
      "umls:spco": 1
    }
  },
  {
    "qid": "5311d130e3eabad021000009",
    "question": "Which proteins in the cerebro-spinal fluid can be used for early diagnosis of Alzheimer\u0027s disease?",
    "answer-types": {
      "beta-amyloid": [
        "umls:lbpr"
      ],
      "phosphorylated tau": [
        "umls:lbpr"
      ]
    },
    "type-counts": {
      "umls:lbpr": 2
    }
  },
  {
    "qid": "56ae70050a360a5e4500000f",
    "question": "What is the role of the RUNX1-MYEF2 complex?",
    "answer-types": {
      "The repression of hematopoietic genes in erythroid cells.": []
    },
    "type-counts": {}
  },
  {
    "qid": "52f509232059c6d71c00001f",
    "question": "Which genes are implicated in short QT syndrome?",
    "answer-types": {
      "KCNH2": [
        "umls:gngm"
      ],
      "inward rectifier potassium channel gene": [],
      "HERG": [
        "umls:gngm"
      ],
      "KCNQ1": [
        "umls:gngm"
      ],
      "CACNA2D1": [
        "umls:gngm"
      ],
      "CACNB2b": [],
      "KCNJ2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 5
    }
  },
  {
    "qid": "535d69177d100faa09000003",
    "question": "What is SCENAR therapy used for?",
    "answer-types": {
      "pain in postherpetic neuralgia": [],
      "duodenal ulcer": [
        "umls:dsyn"
      ],
      "peritonitis postoperative": [
        "umls:patf"
      ],
      "nocturnal enuresis": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:mobd": 1,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "56be1723ef6e39474100000c",
    "question": "List symptoms of Gradenigo\u0027s syndrome.",
    "answer-types": {
      "abducens nerve paralysis": [
        "umls:dsyn"
      ],
      "otitis media": [
        "umls:dsyn"
      ],
      "deep facial pain": []
    },
    "type-counts": {
      "umls:dsyn": 2
    }
  },
  {
    "qid": "53261e79600967d132000003",
    "question": "What is the relationship between thyroid hormone and inflammatory markers in heart failure patients?",
    "answer-types": {
      "There is an inverse correlation between inflammatory markers and FT3 circulating levels": []
    },
    "type-counts": {}
  },
  {
    "qid": "550e9d2cb305b40c5c000001",
    "question": "Which variables are included in the SPAN-100 score?",
    "answer-types": {
      "NIH Stroke Scale score": [
        "umls:fndg"
      ],
      "Age": [
        "umls:orga"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:orga": 1
    }
  },
  {
    "qid": "516c0ed3298dcd4e5100006f",
    "question": "Which genes does thyroid hormone receptor alpha1 regulate in the liver?",
    "answer-types": {
      "deiodinase 1": [
        "umls:enzy",
        "umls:aapp"
      ],
      "phosphoenolpyruvate-carboxykinase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "pyruvate kinase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "D1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 3,
      "umls:gngm": 1,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56f961b3cf1c325851000003",
    "question": "What is the color of the protein Ranasmurfin?",
    "answer-types": {
      "Blue": [
        "umls:qlco"
      ]
    },
    "type-counts": {
      "umls:qlco": 1
    }
  },
  {
    "qid": "516ec97f298dcd4e51000087",
    "question": "By which methods can we evaluate the reliability of a phylogenetic tree?",
    "answer-types": {
      "jackknife": [
        "umls:dsyn"
      ],
      "bootstrap": [
        "umls:qnco"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1,
      "umls:qnco": 1
    }
  },
  {
    "qid": "53372ba3d6d3ac6a34000058",
    "question": "Which histone modification is primarily linked to elongating transcription?",
    "answer-types": {
      "H3K36 trimethylation": [],
      "H3K36me3": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c1f02aef6e39474100004b",
    "question": "Which interleukin is blocked by Siltuximab?",
    "answer-types": {
      "interleukin-6": [
        "umls:imft",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "551fd9c06b348bb82c000012",
    "question": "ROSIER scale is used for which disorder?",
    "answer-types": {
      "stroke": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54d7a1047035c08008000002",
    "question": "Which is the subcellular localization of the protein angiogenin?",
    "answer-types": {
      "Both nucleolar and cytoplasmic": []
    },
    "type-counts": {}
  },
  {
    "qid": "5324d0169b2d7acc7e000022",
    "question": "List FDA approved treatments for androgenetic allopecia",
    "answer-types": {
      "Finasteride": [
        "umls:orch",
        "umls:horm",
        "umls:phsu"
      ],
      "Laser hair comb": [
        "umls:medd"
      ],
      "Minoxidil": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 2,
      "umls:medd": 1,
      "umls:horm": 1,
      "umls:phsu": 2
    }
  },
  {
    "qid": "55054f8af73303d458000002",
    "question": "Which bone protein is used in archaelogy for dating and species identification?",
    "answer-types": {
      "Collagen": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:aapp": 1
    }
  },
  {
    "qid": "54fc9ca16ad7dcbc12000006",
    "question": "Which receptors are targeted by suvorexant?",
    "answer-types": {
      "orexin 1": [
        "umls:gngm"
      ],
      "orexin 2": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:rcpt": 1,
      "umls:gngm": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "515d7693298dcd4e5100000c",
    "question": "A common problem in proteomics is the contamination of samples with exogenous proteins (often from other species). These proteins can be found in specific databases. List some contaminants.",
    "answer-types": {
      "Keratins": [
        "umls:aapp"
      ],
      "Proteases": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Antibodies": [
        "umls:imft",
        "umls:aapp"
      ],
      "Bovine serum proteins": []
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:imft": 1,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56f7c15a09dd18d46b000012",
    "question": "Which gene has been implicated in Majeed Syndrome?",
    "answer-types": {
      "LPIN2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "5523e7837b523f2123000006",
    "question": "What is Trypan blue used for?",
    "answer-types": {
      "cell viability - cell death assessment": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c1f045ef6e394741000058",
    "question": "Selexipag is used for which disease?",
    "answer-types": {
      "pulmonary arterial hypertension": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "56c1f030ef6e39474100004d",
    "question": "List features of the DEND syndrome.",
    "answer-types": {
      "epilepsy": [
        "umls:dsyn"
      ],
      "neonatal diabetes": [
        "umls:dsyn"
      ],
      "developmental delay": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:mobd": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "5708992ccf1c32585100000d",
    "question": "What is the RESID database?",
    "answer-types": {
      "The RESID Database of Protein Modifications is a comprehensive collection of annotations and structures for protein modifications and cross-links including pre-, co-, and post-translational modifications": []
    },
    "type-counts": {}
  },
  {
    "qid": "52d8494698d0239505000007",
    "question": "Which genes have been found mutated in Gray platelet syndrome patients?",
    "answer-types": {
      "GFI1B": [
        "umls:gngm"
      ],
      "neurobeachin-like 2": [
        "umls:gngm"
      ],
      "NBEAL2": [
        "umls:gngm"
      ],
      "GATA1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 4
    }
  },
  {
    "qid": "550ea8f1b305b40c5c000005",
    "question": "Pridopidine has been tested for treatment of which disorder?",
    "answer-types": {
      "Huntington disease": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "5319a708b166e2b806000024",
    "question": "Which is the target of bortezomib used in cancer therapy?",
    "answer-types": {
      "The ubiquitin/proteasome pathway": []
    },
    "type-counts": {}
  },
  {
    "qid": "550312b4e9bde6963400001c",
    "question": "Which genes are known to be involved in Diamond-Blackfan anemia?",
    "answer-types": {
      "RPS26": [
        "umls:gngm"
      ],
      "RPL5": [
        "umls:gngm"
      ],
      "RPS17": [
        "umls:gngm"
      ],
      "RPS7": [
        "umls:gngm"
      ],
      "RPS19": [
        "umls:bacs",
        "umls:aapp"
      ],
      "RPL11": [
        "umls:gngm"
      ],
      "RPL35A": [
        "umls:gngm"
      ],
      "RPL26": [
        "umls:gngm"
      ],
      "GATA1": [
        "umls:gngm"
      ],
      "RPS10": [
        "umls:gngm"
      ],
      "RPS24": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 10,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56cf3f4f3975bb303a000008",
    "question": "Which is the chromosomal location of the gene MAOA?",
    "answer-types": {
      "Xp21-p11": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c079b1ef6e394741000022",
    "question": "Idarucizumab is an antidote of which drug?",
    "answer-types": {
      "dabigatran": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "56d8b47a51531f7e33000004",
    "question": "What are the main clinical characteristics of Pendred syndrome?",
    "answer-types": {
      "goiter": [
        "umls:patf"
      ],
      "congenital sensorineural deafness": [
        "umls:cgab"
      ],
      "impaired iodide organification": []
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:cgab": 1
    }
  },
  {
    "qid": "5709f027cf1c32585100001f",
    "question": "What is the Pfam database?",
    "answer-types": {
      "The Pfam database is a collection of curated protein families.": []
    },
    "type-counts": {}
  },
  {
    "qid": "5178d6be8ed59a060a000038",
    "question": "What is a popular mesaure of gene expression in RNA-seq experiments?",
    "answer-types": {
      "Reads Per Kilobase per Million mapped reads": [],
      "Reads Per Kilobase per Million mapped reads (RPKM)": [],
      "RPKM": []
    },
    "type-counts": {}
  },
  {
    "qid": "531dd4af267d7dd05300000d",
    "question": "Inhibition of which enzyme is mechanism of action of alisertib?",
    "answer-types": {
      "aurora kinase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54edaee3445c3b5a5f000003",
    "question": "List the three most prevalent pathogenic species of Borrelia in Europe.",
    "answer-types": {
      "B. garinii": [
        "umls:clna"
      ],
      "B. afzelii": [
        "umls:euka"
      ],
      "B. burgdorferi ss.": []
    },
    "type-counts": {
      "umls:clna": 1,
      "umls:euka": 1
    }
  },
  {
    "qid": "52ece29f98d023950500002c",
    "question": "Which thyroid hormone transporter is implicated in thyroid hormone resistance syndrome?",
    "answer-types": {
      "monocarboxylate transporter 8": [
        "umls:gngm"
      ],
      "MCT8": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 2
    }
  },
  {
    "qid": "5506eca18e1671127b00000f",
    "question": "Which are the subunits of the transcription factor NF-kappaB in the canonical pathway activation?",
    "answer-types": {
      "NF-κB1": [],
      "p50": [
        "umls:fndg"
      ],
      "p65": [
        "umls:bacs",
        "umls:aapp"
      ],
      "RelA": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:gngm": 1,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5148691bd24251bc0500002d",
    "question": "Which protein is affected by dusp8 activation?",
    "answer-types": {
      "JNK": [
        "umls:moft"
      ]
    },
    "type-counts": {
      "umls:moft": 1
    }
  },
  {
    "qid": "5335d4e8d6d3ac6a34000053",
    "question": "Which receptors are targeted by a drug Macitentan?",
    "answer-types": {
      "endothelin receptor B": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "endothelin receptor A": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:rcpt": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "518ba4b5310faafe08000005",
    "question": "Which drugs are utilized to treat eosinophilic esophagitis?",
    "answer-types": {
      "budesonide": [
        "umls:orch",
        "umls:phsu"
      ],
      "proton pump inhibitors": [
        "umls:phsu"
      ],
      "immunosoppressive drugs": []
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 2
    }
  },
  {
    "qid": "56c3320a50c68dd416000008",
    "question": "What is the incidence of cystic fibrosis in the caucasian population?",
    "answer-types": {
      "1:2000": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "56b7210b76d8bf8d13000004",
    "question": "What is the effect of thapsigargin treatment?",
    "answer-types": {
      "Thapsigargin is a sarcoplasmic/endoplasmic Ca(2+)-ATPase (SERCA) inhibitor.": []
    },
    "type-counts": {}
  },
  {
    "qid": "5318929fb166e2b80600001b",
    "question": "What is the Her2 status in Li-Fraumeni syndrome?",
    "answer-types": {
      "Her2 status is positive": []
    },
    "type-counts": {}
  },
  {
    "qid": "51475d5cd24251bc0500001b",
    "question": "Where is X-ray free electron laser used?",
    "answer-types": {
      "high resolution protein structure determination": [],
      "study of enzyme kinetics": [],
      "molecular imaging": [
        "umls:diap"
      ],
      "single-particle imaging": [],
      "time resolved protein crystallography": []
    },
    "type-counts": {
      "umls:diap": 1
    }
  },
  {
    "qid": "54db7c4ac0bb8dce23000001",
    "question": "Which protein kinases have been found to phosphorylate Phospholamban and affect its biological activity?",
    "answer-types": {
      "CaMKII": [
        "umls:enzy",
        "umls:aapp"
      ],
      "akt kinase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "PKA": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Ca(2+) /calmodulin-dependent protein kinase II": [
        "umls:enzy",
        "umls:aapp"
      ],
      "protein kinase G": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Akt": [
        "umls:enzy",
        "umls:aapp"
      ],
      "protein kinase A": [
        "umls:enzy",
        "umls:aapp"
      ],
      "PKG": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 8,
      "umls:aapp": 8
    }
  },
  {
    "qid": "54e0c3e71388e8454a000013",
    "question": "Which enzyme is inhibited by Orteronel?",
    "answer-types": {
      "CYP17A1": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54db5e24bcba1b1817000002",
    "question": "What is the disorder in which mutations in U4atac snRNA are detected?",
    "answer-types": {
      "Microcephalic osteodysplastic primordial dwarfism type I (MOPDI)": [
        "umls:cgab"
      ],
      "MOPDI": [
        "umls:cgab"
      ],
      "Microcephalic osteodysplastic primordial dwarfism type I": [
        "umls:cgab"
      ]
    },
    "type-counts": {
      "umls:cgab": 3
    }
  },
  {
    "qid": "515d692c298dcd4e5100000a",
    "question": "Which is the binding site motif of Sp1?",
    "answer-types": {
      "(G/T)GGGCGG(G/A)(G/A)(C/T)": []
    },
    "type-counts": {}
  },
  {
    "qid": "56f8077a8b98c98849000002",
    "question": "List autoimmune disorders associated with GAD65 autoantibodies.",
    "answer-types": {
      "cerebellar ataxia": [
        "umls:sosy"
      ],
      "type 1 diabetes": [
        "umls:dsyn"
      ],
      "stiff-person syndrome": [
        "umls:dsyn"
      ],
      "limbic encephalitis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:sosy": 1,
      "umls:dsyn": 3
    }
  },
  {
    "qid": "5503145ee9bde69634000022",
    "question": "How many different subtypes of thyroid cancer exist?",
    "answer-types": {
      "Hürthle cell carcinoma": [
        "_QUANTITY"
      ],
      "Follicular thyroid carcinoma": [
        "_QUANTITY"
      ],
      "Medullary thyroid carcinoma": [
        "_QUANTITY"
      ],
      "Papillary thyroid carcinoma": [
        "_QUANTITY"
      ],
      "Anaplastic thyroid carcinoma": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 5
    }
  },
  {
    "qid": "530cf51d5610acba0c000001",
    "question": "What is the clinical indication of cardiac T1 mapping magnetic resonance?",
    "answer-types": {
      "T1 mapping can quantitatively characterize myocardial tissue, i.e. fibrosis and edema.": []
    },
    "type-counts": {}
  },
  {
    "qid": "53175e9fb166e2b80600000a",
    "question": "What is the physiological role of LKB1 involved in Peutz-Jeghers syndrome?",
    "answer-types": {
      "LKB1 plays a physiological role in controlling the Wnt-signaling.": []
    },
    "type-counts": {}
  },
  {
    "qid": "53265dd4d6d3ac6a34000007",
    "question": "What is the prognostic role of alterred thyroid profile after cardiosurgery?",
    "answer-types": {
      "Altered thyroid profile after cardiosurgery is associated with several events in adults and in children": []
    },
    "type-counts": {}
  },
  {
    "qid": "56be15ffef6e39474100000b",
    "question": "List Pentalogy of Fallot.",
    "answer-types": {
      "patent foramen ovale": [
        "umls:cgab"
      ],
      "overriding aorta": [
        "umls:cgab",
        "umls:dsyn"
      ],
      "ventricular septal defect": [
        "umls:cgab"
      ],
      "right ventricular hypertrophy": [
        "umls:dsyn"
      ],
      "pulmonic stenosis": [
        "umls:dsyn",
        "umls:anab"
      ]
    },
    "type-counts": {
      "umls:cgab": 3,
      "umls:dsyn": 3,
      "umls:anab": 1
    }
  },
  {
    "qid": "55149f156a8cde6b72000013",
    "question": "Which gene fusion is the result of the \"philadelphia translocation\" or the \"philadelphia chromosome\" mutation?",
    "answer-types": {
      "ABL/BCR fusion": [
        "umls:bacs",
        "umls:aapp"
      ],
      "The BCR/ABL gene fusion": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52f637972059c6d71c000025",
    "question": "Which gene mutations are responsible for isolated Non-compaction cardiomyopathy?",
    "answer-types": {
      "c.349G\u003eA (p.D117N) in the ZASP gene": [],
      "mutation in the isoform-1 specific region of the DSP C-terminus": [],
      "p.D117N": [],
      "c.349G\u003eA": [],
      "MYH7": [
        "umls:gngm"
      ],
      "pE96K mutation": []
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "571e40a8bb137a4b0c000009",
    "question": "Which syndrome is associated with OATP1B1 and OATP1B3 deficiency?",
    "answer-types": {
      "Rotor syndrome": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "530cf4fe960c95ad0c00000b",
    "question": "Which type of lung cancer is afatinib used for?",
    "answer-types": {
      "EGFR-mutant NSCLC": [],
      "EGFR-mutant non small cell lung carcinoma": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c1f009ef6e39474100003c",
    "question": "Which disease is treated with Eliglustat?",
    "answer-types": {
      "Gaucher\u0027s disease type 1": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "5333f728d6d3ac6a34000041",
    "question": "List algorithms suitable for predicting protein complexes",
    "answer-types": {
      "CPM": [
        "umls:orch",
        "umls:phsu"
      ],
      "Negatome": [],
      "ClusterONE": [],
      "NFC": [],
      "PIPE": [
        "umls:phsu"
      ],
      "Support Vector Machine": [
        "umls:qnco"
      ],
      "EAGLE": [
        "umls:bird"
      ],
      "Core-Attachment": [],
      "NDComplex": [],
      "CMC": [
        "umls:topp"
      ],
      "PROCOMOSS": [],
      "Struct2net": [],
      "NWE": [],
      "Naïve Bayes Classifier": [],
      "HKC": [],
      "PPI network": [],
      "EPOF": [],
      "DPClus": [],
      "ProRank": [],
      "metaPIS": [],
      "SPICi": [],
      "MCODE": [],
      "CFinder": [],
      "IPCA": [
        "umls:orch",
        "umls:phsu"
      ],
      "Affinity Propagation": [],
      "RNSC": [],
      "PEWCC": [],
      "iPTMClust": [],
      "MCL": [
        "umls:neop"
      ],
      "Spectral": [
        "umls:qnco"
      ],
      "CP-DR": []
    },
    "type-counts": {
      "umls:bird": 1,
      "umls:neop": 1,
      "umls:orch": 2,
      "umls:topp": 1,
      "umls:qnco": 2,
      "umls:phsu": 3
    }
  },
  {
    "qid": "54e0ace81388e8454a000010",
    "question": "Is APOBEC3B protein predominantly cytoplasmic or nuclear?",
    "answer-types": {
      "nuclear": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "56afe6d40a360a5e45000017",
    "question": "Which tool is used for promoterome mining using CAGE data?",
    "answer-types": {
      "CAGEr": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52e62bae98d0239505000015",
    "question": "What is the life expectancy of professional athletes in respect to the general population?",
    "answer-types": {
      "No clear results indicating improved life expectancy in professional athletes": []
    },
    "type-counts": {}
  },
  {
    "qid": "51434c74d24251bc0500000c",
    "question": "What are the computational tools for the prediction of beta-barrel transmembrane proteins?",
    "answer-types": {
      "BTMX": [],
      "BETAWARE": [],
      "PV": [
        "umls:antb",
        "umls:orch"
      ],
      "transFold": [],
      "TMB finding pipeline": [],
      "TMB-Hunt": [],
      "TMBHMM": [],
      "OMPdb": [],
      "BOCTOPUS": [],
      "BOMP": [
        "umls:topp"
      ],
      "PROB": [
        "umls:orch",
        "umls:phsu"
      ],
      "TMBKNN": [],
      "TMBETA-NET": [],
      "ProfTMB": [],
      "TMBpro": [],
      "PRED-TMBB": [],
      "HMM-B2TMR": [],
      "TMB-Hunt2": [],
      "TMBETAPRED-RBF": [],
      "TMBETADISC-RBF": []
    },
    "type-counts": {
      "umls:antb": 1,
      "umls:orch": 2,
      "umls:topp": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "56c1f00cef6e39474100003e",
    "question": "Aleglitazar is agonist of which receptor?",
    "answer-types": {
      "peroxisome proliferator-activated receptor-α/γ": []
    },
    "type-counts": {}
  },
  {
    "qid": "515b30d8d24251bc050000b0",
    "question": "Where can we find the protein lacritin?",
    "answer-types": {
      "thyroid": [
        "umls:dsyn"
      ],
      "tear fluid": [
        "umls:bdsu"
      ],
      "salivary glands": [
        "umls:dsyn"
      ],
      "lacrimal gland": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:bpoc": 1,
      "umls:dsyn": 2,
      "umls:bdsu": 1
    }
  },
  {
    "qid": "532f49f8d6d3ac6a34000035",
    "question": "What is the triple screening test performed during pregnancy measuring?",
    "answer-types": {
      "Estriol": [
        "umls:orch",
        "umls:horm",
        "umls:phsu"
      ],
      "AFP": [
        "umls:bacs",
        "umls:aapp"
      ],
      "hCG": [
        "umls:horm",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:horm": 2,
      "umls:bacs": 1,
      "umls:aapp": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "5150f401d24251bc05000075",
    "question": "What are the generic versions of Viagra?",
    "answer-types": {
      "Vega": [
        "umls:fndg"
      ],
      "Suhagra-100": [],
      "Caverta": [],
      "Elonza": [],
      "Zenegra-100": [],
      "Vega Asia": []
    },
    "type-counts": {
      "umls:fndg": 1
    }
  },
  {
    "qid": "56caea805795f9a73e00002c",
    "question": "Which protein interacts with the Ragulator-RAG GTPases to control mTOR activity?",
    "answer-types": {
      "Amino Acid-DepeLysosomal Membrane Protein SLC38A9": []
    },
    "type-counts": {}
  },
  {
    "qid": "51601071298dcd4e51000038",
    "question": "Against which organisms has reverse vaccinology been used?",
    "answer-types": {
      "Porphyromonas gingivalis": [
        "umls:bact"
      ],
      "Bacillus anthracis": [
        "umls:bact"
      ],
      "Chlamydia pneumoniae": [
        "umls:bact"
      ],
      "Neisseria meningitidis (serogroup B)": [
        "umls:bact"
      ],
      "Theileria parva": [
        "umls:euka"
      ],
      "Neisseria meningitidis": [
        "umls:bact"
      ],
      "Leishmania spp": [],
      "Streptococcus pneumoniae": [
        "umls:bact"
      ],
      "Brachyspira hyodysenteriae": [
        "umls:bact"
      ],
      "group B streptococci": [
        "umls:enzy",
        "umls:aapp",
        "umls:phsu"
      ],
      "Helicobacter pylori": [
        "umls:bact"
      ],
      "Mycobacterium tuberculosis": [
        "umls:bact"
      ],
      "serogroup B": [
        "umls:dsyn"
      ],
      "Brucella melitensis": [
        "umls:bact"
      ],
      "Ehrlichia ruminantium": [
        "umls:bact"
      ],
      "Echinococcus granulosus": [
        "umls:dsyn"
      ],
      "Rhipicephalus microplus": [
        "umls:euka"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:euka": 2,
      "umls:dsyn": 2,
      "umls:phsu": 1,
      "umls:aapp": 1,
      "umls:bact": 11
    }
  },
  {
    "qid": "56c1f021ef6e394741000048",
    "question": "Galassi classification is used for which disorder?",
    "answer-types": {
      "arachnoid cyst": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "515993f3d24251bc050000a0",
    "question": "Which compounds exist that are thyroid hormone analogs?",
    "answer-types": {
      "DITPA": [
        "umls:orch"
      ],
      "3,3\u0027,5,5\u0027-tetraiodo-thyroacetic acid": [],
      "3,5-T2": [
        "umls:aapp"
      ],
      "IpTA2": [],
      "KB-141": [
        "umls:orch"
      ],
      "CGS 23425": [
        "umls:orch",
        "umls:phsu"
      ],
      "GC-24": [
        "umls:orch"
      ],
      "triac": [
        "umls:orch",
        "umls:phsu"
      ],
      "D-T3": [],
      "3,5-Diiodo-4-hydroxyphenylpropionic acid": [
        "umls:orch"
      ],
      "3,5-diiodo-3\u0027-isopropylthyroacetic acid": [
        "umls:orch",
        "umls:phsu"
      ],
      "3,5-diiodothyropropionic acid": [
        "umls:orch"
      ],
      "T2": [
        "umls:fndg"
      ],
      "3,3\u0027,5-triiodo-thyroacetic acid": [],
      "GC-1": [
        "umls:orch",
        "umls:phsu"
      ],
      "3,5-Dimethyl-3\u0027-isopropyl-L-thyronine": [
        "umls:aapp"
      ],
      "3,5-diiodo-L-tyrosine": [
        "umls:aapp"
      ],
      "Tetrac": [
        "umls:orch",
        "umls:phsu"
      ],
      "3,5-diiodo-L-thyronine": [
        "umls:aapp"
      ],
      "DIT": [
        "umls:hops",
        "umls:orch",
        "umls:phsu"
      ],
      "CO23": [
        "umls:orch"
      ],
      "DIMIT": [
        "umls:aapp"
      ],
      "DIHPA": [
        "umls:orch"
      ],
      "thyronamines": [],
      "3,3\u0027,5-triiodo-D-thyronine": [],
      "MIT": [
        "umls:bacs",
        "umls:aapp"
      ],
      "KB-2115": [
        "umls:orch"
      ],
      "T4-agarose": [],
      "3-monoiodo-L-tyrosine": []
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:hops": 1,
      "umls:orch": 14,
      "umls:bacs": 1,
      "umls:phsu": 6,
      "umls:aapp": 6
    }
  },
  {
    "qid": "53357c98d6d3ac6a3400004a",
    "question": "What genes are related to breast cancer?",
    "answer-types": {
      "TOP2A": [
        "umls:enzy",
        "umls:aapp"
      ],
      "NRF2": [
        "umls:gngm"
      ],
      "ERBB2": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "BRCA1": [
        "umls:gngm"
      ],
      "RPS2": [
        "umls:gngm"
      ],
      "HER2": [
        "umls:enzy",
        "umls:rcpt",
        "umls:aapp"
      ],
      "BRCA2": [
        "umls:gngm"
      ],
      "TP53": [
        "umls:gngm"
      ],
      "BRCT": [
        "umls:amas"
      ],
      "TRIM22": [
        "umls:gngm"
      ],
      "p53": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 3,
      "umls:rcpt": 2,
      "umls:amas": 1,
      "umls:gngm": 7,
      "umls:aapp": 3
    }
  },
  {
    "qid": "52bf1d9e03868f1b06000010",
    "question": "To the ligand of which receptors does Denosumab (Prolia) bind?",
    "answer-types": {
      "RANKL": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5523e47f7b523f2123000004",
    "question": "List fluorescent reporter proteins.",
    "answer-types": {
      "Gfp": [
        "umls:irda",
        "umls:aapp"
      ],
      "red fluorescent protein": [
        "umls:aapp"
      ],
      "mCherry": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Timer": [
        "umls:medd"
      ],
      "dsRed": [
        "umls:bacs",
        "umls:aapp"
      ],
      "enhanced green fluorescent reporter protein": [],
      "yellow fluorescent protein": [
        "umls:bacs",
        "umls:aapp"
      ],
      "coral fluorescent reporter protein": [],
      "DsRed1-E5": [],
      "green fluorescent protein": [
        "umls:irda",
        "umls:aapp"
      ],
      "beta-phycoerythrin": []
    },
    "type-counts": {
      "umls:irda": 2,
      "umls:medd": 1,
      "umls:bacs": 3,
      "umls:aapp": 6
    }
  },
  {
    "qid": "54fb5720d176fff445000002",
    "question": "Which transcription factors are known as the four (4) \"Yamanaka factors\" that have been used to create induced pluripotent stem cells (iPSCs)?",
    "answer-types": {
      "Oct4": [
        "umls:gngm"
      ],
      "Sox2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "c-Myc": [
        "umls:gngm"
      ],
      "Oct 3/4": [
        "umls:orch",
        "umls:phsu"
      ],
      "Klf4": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:bacs": 1,
      "umls:gngm": 3,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56fcf1b8cf1c325851000005",
    "question": "Which type of genes are modulated by SATB1?",
    "answer-types": {
      "it supresses cell cytokines and differentiation genes": []
    },
    "type-counts": {}
  },
  {
    "qid": "5363bad27d100faa0900000e",
    "question": "Which are the most abundant human lincRNA?",
    "answer-types": {
      "H19": [
        "umls:gngm"
      ],
      "NEAT2": [
        "umls:gngm"
      ],
      "MALAT-1": [
        "umls:gngm"
      ],
      "MALAT1": [
        "umls:gngm"
      ],
      "XIST": [
        "umls:gngm"
      ],
      "NEAT1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 6
    }
  },
  {
    "qid": "56cafa845795f9a73e00002e",
    "question": "Which protein pathway is regulating SGK1-mediated phosphorylation of FOXO3a to control cell proliferation?",
    "answer-types": {
      "The mTOR pathway": [
        "umls:moft"
      ]
    },
    "type-counts": {
      "umls:moft": 1
    }
  },
  {
    "qid": "532b15ecd6d3ac6a34000014",
    "question": "Which drugs have been found effective for the treatment of chordoma?",
    "answer-types": {
      "SD-1029 Stat3 inhibitor": [],
      "vincristine": [
        "umls:orch",
        "umls:phsu"
      ],
      "fludarabine": [
        "umls:nnon",
        "umls:phsu"
      ],
      "etoposide": [
        "umls:orch",
        "umls:phsu"
      ],
      "doxorubicin": [
        "umls:antb",
        "umls:orch"
      ],
      "bortezomib": [
        "umls:orch",
        "umls:phsu"
      ],
      "cisplatin": [
        "umls:inch",
        "umls:phsu"
      ],
      "pingyangmycin lipiodol emulsion": []
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:inch": 1,
      "umls:antb": 1,
      "umls:orch": 4,
      "umls:phsu": 5
    }
  },
  {
    "qid": "56c830635795f9a73e00000e",
    "question": "Which components of the stress granules are known to be related to motor neuron degeneration in Amyotrophic Lateral Sclerosis?",
    "answer-types": {
      "FUS": [
        "umls:dsyn"
      ],
      "TDP-43": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5720a8da0fd6f91b68000010",
    "question": "Which could be some of the possible causes of hypersomnia?",
    "answer-types": {
      "traumatic brain injury": [
        "umls:inpo"
      ],
      "dementia": [
        "umls:mobd"
      ],
      "traumatic brain injury (TBI)": [
        "umls:inpo"
      ],
      "TBI": [
        "umls:inpo"
      ],
      "sleep apnea": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:mobd": 1,
      "umls:inpo": 3,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54f5bc7d5f206a0c06000001",
    "question": "What is the function of caspases?",
    "answer-types": {
      "Caspases are intracellular proteases that propagate programmed cell death, proliferation, and inflammation.": []
    },
    "type-counts": {}
  },
  {
    "qid": "54d8d60d014675820d000007",
    "question": "List BRAF inhibitors that have been tested in clinical trials for treatment of melanoma patients",
    "answer-types": {
      "Vemurafenib": [
        "umls:orch",
        "umls:phsu"
      ],
      "Dabrafenib": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "531375a6e3eabad021000011",
    "question": "which are the risk factors for sudden cardiac death in patients with hypertrophic cardiomyopathy?",
    "answer-types": {
      "J-wave on ECG": [
        "umls:fndg"
      ],
      "high-risk genetic mutations": [],
      "previous cardiac arrest": [
        "umls:patf"
      ],
      "unexplained syncope": [],
      "myocardial fibrosis using late gadolinium enhancement": [],
      "Extreme left ventricular hypertrophy": [],
      "Extreme left ventricular hypertrophy (\u003e30mm)": [],
      "\u003e30mm": [
        "umls:qnco"
      ],
      "Nonsustained ventricular tachycardia": [
        "umls:patf"
      ],
      "Sustained ventricular tachycardia": [
        "umls:dsyn"
      ],
      "family history of sudden cardiac death": [
        "umls:fndg"
      ],
      "hypotensive response to exercise": []
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:patf": 2,
      "umls:dsyn": 1,
      "umls:qnco": 1
    }
  },
  {
    "qid": "531af8cbb166e2b80600003a",
    "question": "How many genes outside of the MHC locus have been genetically associated to Rheumatoid Arthritis through GWAS?",
    "answer-types": {
      "more than 30": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "56d1e23c67f0cb3d66000009",
    "question": "Which are the coactivators of the Yes-associated protein (yap)?",
    "answer-types": {
      "Tead": [
        "umls:bacs",
        "umls:aapp"
      ],
      "TEA domain": [
        "umls:gngm"
      ],
      "Tead (TEA domain) transcription factors.": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:gngm": 1,
      "umls:bacs": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "5544de7a5beec11c10000005",
    "question": "In which phase of cell cycle does stress-induced transcription-associated mutagenesis (TAM) occur?",
    "answer-types": {
      "stationary phase": [
        "umls:resd"
      ]
    },
    "type-counts": {
      "umls:resd": 1
    }
  },
  {
    "qid": "531b3ff3b166e2b80600003d",
    "question": "Which proteins are related to the loss of cell-cell adhesion during EMT (epithelial-mesenchymal transition)?",
    "answer-types": {
      "Par6": [
        "umls:gngm"
      ],
      "EGF": [
        "umls:bacs",
        "umls:aapp"
      ],
      "ZEB": [
        "umls:gngm"
      ],
      "TGFb": [
        "umls:moft"
      ],
      "aPKC": [
        "umls:enzy",
        "umls:aapp"
      ],
      "SIRT1": [
        "umls:gngm"
      ],
      "SNAIL": [
        "umls:euka"
      ]
    },
    "type-counts": {
      "umls:moft": 1,
      "umls:enzy": 1,
      "umls:euka": 1,
      "umls:bacs": 1,
      "umls:gngm": 3,
      "umls:aapp": 2
    }
  },
  {
    "qid": "55421ee7ccca0ce74b000002",
    "question": "Which tumor suppressor is referred to as \"the guardian of the genome\"?",
    "answer-types": {
      "p53": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "514a0a57d24251bc05000051",
    "question": "Which drug should be used as an antidote in benzodiazepine overdose?",
    "answer-types": {
      "flumazenil": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "5314c7afdae131f84700000a",
    "question": "List common features of Shapiro syndrome",
    "answer-types": {
      "congenital agenesis of the corpus callosum": [
        "umls:dsyn"
      ],
      "hyperhidrosis": [
        "umls:fndg"
      ],
      "recurrent hypothermia": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "52f5417b2059c6d71c000024",
    "question": "List mouse models for autism spectrum disorder (ASD).",
    "answer-types": {
      "maternal immune activation (MIA) mouse model of gestational poly(IC) exposure": [],
      "Tsc2f/-": [],
      "Shank3-deficient mice": [],
      "MALTT": [],
      "C58/J": [
        "umls:mamm"
      ],
      "TS2-neo mouse": [],
      "VPA600": [],
      "C57BL/6J": [
        "umls:mamm"
      ],
      "HT": [
        "umls:geoa"
      ],
      "NR1(neo-/-)": [],
      "SYNGAP1": [
        "umls:gngm"
      ],
      "(Dp(11)17/+)": [],
      "BTBR T+tf/J (BTBR)": [],
      "Tbx1 heterozygous (HT) mice": [],
      "MIA) mouse model of gestational poly(IC": [],
      "Tbx1 heterozygous": [],
      "ProSAP1/Shank2": [],
      "maternal immune activation": [],
      "Grin1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:mamm": 2,
      "umls:geoa": 1,
      "umls:gngm": 2
    }
  },
  {
    "qid": "5717ab7ccb4ef8864c00000c",
    "question": "Which are the main functions of G3BP1 and G3BP2 proteins?",
    "answer-types": {
      "Initiation of assembly of stress granules": [],
      "Limit viral replication events during Sindbis virus (SINV) infection": [],
      "Translation of interferon stimulated mRNAs during dengue virus infection": [],
      "SINV": [
        "umls:clna"
      ],
      "Regulation of PMP22 mRNA which was found to affect cell proliferation in breast cancer cells": [],
      "Limit viral replication events during Sindbis virus": [],
      "Participation in several signaling pathways involved in growth, differentiation and apoptosis in human tumor cells after overexpression": [],
      "Modulation of p53 and MDM2 activity": []
    },
    "type-counts": {
      "umls:clna": 1
    }
  },
  {
    "qid": "53036faab24d855b11000001",
    "question": "What is the incidence of sudden cardiac death among young athletes?",
    "answer-types": {
      "0.5  to 3  per 100,000 athletes per year": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "53262cdcd6d3ac6a34000003",
    "question": "What is the definitive treatment for low pressure headache?",
    "answer-types": {
      "epidural blood patch": [
        "umls:topp"
      ]
    },
    "type-counts": {
      "umls:topp": 1
    }
  },
  {
    "qid": "56c6dc6f5795f9a73e000007",
    "question": "Which post-translational histone modifications are characteristic of facultative heterochromatin?",
    "answer-types": {
      "H3K9me2": [],
      "H3K9me3": [],
      "H3K36me3": []
    },
    "type-counts": {}
  },
  {
    "qid": "56f5692f09dd18d46b00000a",
    "question": "Mutations in which genes have been associated with Aicardi-Goutieres syndrome?",
    "answer-types": {
      "RNASEH2C": [
        "umls:gngm"
      ],
      "RNASEH2B": [
        "umls:gngm"
      ],
      "RNASEH2A": [
        "umls:gngm"
      ],
      "TREX1": [
        "umls:gngm"
      ],
      "ADAR": [
        "umls:gngm"
      ],
      "SAMHD1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 6
    }
  },
  {
    "qid": "530a3e18970c65fa6b000005",
    "question": "List bacteria that may be useful in uranium bioremediation.",
    "answer-types": {
      "strain Rf4T": [],
      "Shewanella oneidensis": [
        "umls:bact"
      ],
      "Geobacteraceae": [
        "umls:bact"
      ],
      "Pseudomonas aeruginosa": [
        "umls:bact"
      ],
      "Betaproteobacteria": [
        "umls:bact"
      ],
      "Geobacter": [
        "umls:bact"
      ],
      "Geobacter uraniireducens": [
        "umls:bact"
      ],
      "Anaeromyxobacter dehalogenans": [
        "umls:bact"
      ],
      "Firmicutes": [
        "umls:bact"
      ]
    },
    "type-counts": {
      "umls:bact": 8
    }
  },
  {
    "qid": "52fb7c512059c6d71c000069",
    "question": "How much should be the duration of the QT interval in patients with short QT syndrome?",
    "answer-types": {
      "below 300-330 msec": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "5162e44f298dcd4e5100004a",
    "question": "The protein neprilysin has an positive effect on Alzheimer disease, how can it be delivered to the brain?",
    "answer-types": {
      "Gene Induction": [
        "umls:genf"
      ],
      "peripheral": [
        "umls:spco"
      ],
      "Fusion of the Apolipoprotein B": [],
      "Convection-enhanced delivery": [
        "umls:ftcn"
      ],
      "Fusion of the Apolipoprotein B (ApoB) low-density lipoprotein (LDL) receptor-binding domain to a targeted protein": [],
      "Syringe-focused ultrasound device": [],
      "Gene transfer with non-viral vectors": [],
      "ApoB) low-density lipoprotein (LDL": [],
      "Intracardiac (peripheral) administration of viral neprilysin construct": [
        "umls:bpoc"
      ],
      "Intracardiac": [
        "umls:bpoc"
      ],
      "ex vivo gene therapy": [
        "umls:topp"
      ],
      "Use of human adipose tissue-derived mesenchymal stem cells that secrete functional neprilysin-bound exosomes": [],
      "Gene transfer with viral vectors": [],
      "Transgenesis": [
        "umls:resa"
      ]
    },
    "type-counts": {
      "umls:ftcn": 1,
      "umls:resa": 1,
      "umls:genf": 1,
      "umls:spco": 1,
      "umls:bpoc": 2,
      "umls:topp": 1
    }
  },
  {
    "qid": "56c58f1b5795f9a73e000001",
    "question": "Which species of bacteria did the mitochondria originate from?",
    "answer-types": {
      "Biologists agree that the ancestor of mitochondria was an alpha-proteobacterium.": []
    },
    "type-counts": {}
  },
  {
    "qid": "56f7fe3709dd18d46b000015",
    "question": "Which disease is linked to mutations within BRAG1?",
    "answer-types": {
      "X-linked intellectual disability": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54db62a3034aea571d000001",
    "question": "Which is the main calcium pump of the sarcoplasmic reticulum?",
    "answer-types": {
      "serca2": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Sarcoplasmic reticulum Ca(2+)-ATPase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "SERCA": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:dsyn": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "5344155faeec6fbd07000005",
    "question": "What is the inheritance pattern of Hunter disease or mucopolysaccharidosis II?",
    "answer-types": {
      "X- linked recessive": [
        "umls:fndg"
      ]
    },
    "type-counts": {
      "umls:fndg": 1
    }
  },
  {
    "qid": "553ca8d8f32186855800000d",
    "question": "What is the effect of the absence of Saccharomyces cerevisiae Rrm3p?",
    "answer-types": {
      "Lack of the yeast Rrm3p DNA helicase causes replication defects at multiple sites within ribosomal DNA": [],
      "Lack of the yeast Rrm3p DNA helicase causes replication defects at multiple sites within ribosomal DNA (rDNA), including at the replication fork barrier (RFB).": [],
      "rDNA), including at the replication fork barrier (RFB": []
    },
    "type-counts": {}
  },
  {
    "qid": "532f1452d6d3ac6a34000030",
    "question": "What is the ubiquitin proteome?",
    "answer-types": {
      "The ubiquitin proteome is the entire set ubiquitinated proteins and of their respective ubiquitination sites.": []
    },
    "type-counts": {}
  },
  {
    "qid": "570a922dcf1c325851000028",
    "question": "Which major signaling pathways are regulated by RIP1?",
    "answer-types": {
      "apoptosis": [
        "umls:celf"
      ],
      "pro-survival/inflammation NF-κB activation": [],
      "necroptosis": [
        "umls:celf"
      ]
    },
    "type-counts": {
      "umls:celf": 2
    }
  },
  {
    "qid": "5547ec32f35db7552600000a",
    "question": "What is the effect induced by sympathetic nervous system on pupil size?",
    "answer-types": {
      "increase of the pupil size": [],
      "pupillary dilatation": [
        "umls:sosy"
      ],
      "pupillary dilatation (increase of the pupil size)": [
        "umls:sosy"
      ]
    },
    "type-counts": {
      "umls:sosy": 2
    }
  },
  {
    "qid": "515de572298dcd4e51000021",
    "question": "List all clinical trials of the polypill.",
    "answer-types": {
      "JEWEL 2": [],
      "JEWEL 1": [],
      "UMPIRE": [],
      "CRUCIAL": [
        "umls:food"
      ],
      "ASCOT": [
        "umls:vita",
        "umls:orch",
        "umls:phsu"
      ],
      "GEMINI": [
        "umls:vita",
        "umls:orch"
      ],
      "TOGETHER": [
        "umls:qlco"
      ],
      "CUSP": [
        "umls:blor"
      ],
      "IMPACT": [
        "umls:food"
      ],
      "CAPABLE54": [],
      "GEMINI-AALA": [],
      "AVALON": [
        "umls:virs"
      ],
      "TIPS-2": [
        "umls:orch"
      ],
      "TIPS": [
        "umls:topp"
      ]
    },
    "type-counts": {
      "umls:virs": 1,
      "umls:vita": 2,
      "umls:qlco": 1,
      "umls:orch": 3,
      "umls:topp": 1,
      "umls:blor": 1,
      "umls:phsu": 1,
      "umls:food": 2
    }
  },
  {
    "qid": "5173eb428ed59a060a000021",
    "question": "What type of cancers and inherited diseases have been associated to mutations in the Notch pathway?",
    "answer-types": {
      "CADASIL": [
        "umls:dsyn"
      ],
      "Alagille syndrome": [
        "umls:cgab"
      ],
      "CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)": [
        "umls:dsyn"
      ],
      "spondylocostal dysostosis": [
        "umls:dsyn"
      ],
      "T-cell acute lymphoblastic leukemia": [
        "umls:neop"
      ],
      "cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:cgab": 1,
      "umls:neop": 1,
      "umls:dsyn": 4
    }
  },
  {
    "qid": "52c7275103868f1b0600001c",
    "question": "What is the inheritance pattern of Apert syndrome?",
    "answer-types": {
      "Autosomal dominant": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "5139b31dbee46bd34c000004",
    "question": "Which is the most widely used model for the study of multiple sclerosis (MS)?",
    "answer-types": {
      "Experimental autoimmune encephalomyelitis (EAE)": [
        "umls:emod"
      ],
      "Experimental autoimmune encephalomyelitis": [
        "umls:emod"
      ],
      "EAE": [
        "umls:emod"
      ]
    },
    "type-counts": {
      "umls:emod": 3
    }
  },
  {
    "qid": "52f21b722059c6d71c00000b",
    "question": "What is the usual HER-2 status in breast cancer associated with Li-Fraumeni syndrome?",
    "answer-types": {
      "Positive": [
        "umls:fndg"
      ]
    },
    "type-counts": {
      "umls:fndg": 1
    }
  },
  {
    "qid": "518cb6ab310faafe08000009",
    "question": "What is the treatment of triiodothyronine toxicosis?",
    "answer-types": {
      "thyroidectomy": [
        "umls:topp"
      ],
      "Radioiodine": [
        "umls:elii",
        "umls:irda"
      ],
      "Propyltiouracil": [
        "umls:nnon",
        "umls:phsu"
      ],
      "beta blockers": [
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:elii": 1,
      "umls:irda": 1,
      "umls:topp": 1,
      "umls:phsu": 2
    }
  },
  {
    "qid": "51bdb644047fa84d1d000001",
    "question": "Which are the known human transmembrane nucleoporins?",
    "answer-types": {
      "NDC1": [
        "umls:gngm"
      ],
      "POM121": [
        "umls:gngm"
      ],
      "POM210": [
        "umls:gngm"
      ],
      "GP210": [
        "umls:gngm"
      ],
      "DB83": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Nuclear envelope pore membrane protein POM 210": [],
      "TMEM48": [
        "umls:gngm"
      ],
      "NET3": [
        "umls:gngm"
      ],
      "hNDC1": [],
      "TMEM33": [
        "umls:gngm"
      ],
      "Nup210": [
        "umls:gngm"
      ],
      "Nuclear pore membrane glycoprotein 210": [
        "umls:aapp"
      ],
      "Nup121": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:rcpt": 1,
      "umls:bacs": 1,
      "umls:gngm": 8,
      "umls:aapp": 3
    }
  },
  {
    "qid": "55192892622b194345000012",
    "question": "Which E3 ubiquitin ligase mediates the ubiquitination and degradation of the interferon receptor type 1 (IFNAR1)?",
    "answer-types": {
      "Skp1-Cullin1-HOS-Roc1": [],
      "SCF(HOS)": [],
      "Skp1-Cullin1-F-box protein beta transducin repeat-containing protein": [],
      "βTrcp": [
        "umls:bacs",
        "umls:aapp"
      ],
      "SCFbeta-Trcp (Skp1-Cullin1-F-box protein beta transducin repeat-containing protein)": [],
      "Skp1-Cullin1-HOS-Roc1 (SCF(HOS))": [],
      "beta-Trcp": [
        "umls:bacs",
        "umls:aapp"
      ],
      "SCFbeta-Trcp": []
    },
    "type-counts": {
      "umls:bacs": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "534ab91eaeec6fbd07000012",
    "question": "Which genes were found to be methylated in bladder cancer cells?",
    "answer-types": {
      "TPEF (transmembrane protein containing epidermal growth factor and follistatin domain)": [
        "umls:gngm"
      ],
      "p16": [
        "umls:gngm"
      ],
      "APC": [
        "umls:cell"
      ],
      "RASSF1A": [
        "umls:gngm"
      ],
      "hepaCAM": [
        "umls:gngm"
      ],
      "TPEF": [
        "umls:gngm"
      ],
      "transmembrane protein containing epidermal growth factor and follistatin domain": [],
      "p14(ARF)": [
        "umls:bacs",
        "umls:aapp"
      ],
      "hepatocyte cell adhesion molecule": [
        "umls:gngm"
      ],
      "RARβ(2)": [],
      "hepaCAM (hepatocyte cell adhesion molecule)": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:cell": 1,
      "umls:bacs": 1,
      "umls:gngm": 7,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56cdf4875795f9a73e000040",
    "question": "Which domain of TIA-1 is necessary for stress granule assembly?",
    "answer-types": {
      "PRD": [
        "umls:orch",
        "umls:horm",
        "umls:phsu"
      ],
      "The glutamine-rich prion-related domain (PRD)": [],
      "The glutamine-rich prion-related domain": []
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:horm": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "532dcfc9d6d3ac6a34000021",
    "question": "What is the characteristic domain of histone methyltransferases?",
    "answer-types": {
      "SET domain": [
        "umls:amas"
      ]
    },
    "type-counts": {
      "umls:amas": 1
    }
  },
  {
    "qid": "51740da48ed59a060a000024",
    "question": "Which are the bioinformatics tools for gene structure prediction?",
    "answer-types": {
      "FGENE": [],
      "GLIMMER": [
        "umls:sbst"
      ],
      "TAP": [
        "umls:menp"
      ],
      "GeneBuilder": [],
      "HSPL": [
        "umls:gngm"
      ],
      "TICO": [
        "umls:fish"
      ],
      "HEXON": [
        "umls:orch",
        "umls:phsu"
      ],
      "GeneSeqer": [],
      "CDSB": [],
      "SCGPred": [],
      "WebScipio": [],
      "WPSS": [],
      "FGENEH": [],
      "SplicePredictor": [],
      "SeqHelp": [],
      "HBR": [
        "umls:bpoc"
      ],
      "DGSplicer": [],
      "RNASPL": [],
      "MetWAMer": []
    },
    "type-counts": {
      "umls:fish": 1,
      "umls:sbst": 1,
      "umls:bpoc": 1,
      "umls:orch": 1,
      "umls:menp": 1,
      "umls:gngm": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "5543829fed966d112c000009",
    "question": "Which is the major phytoalexin in alfalfa (Medicago sativa L.)?",
    "answer-types": {
      "medicarpin": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "56f564f909dd18d46b000009",
    "question": "Which syndrome is associated with mutations in the LYST gene?",
    "answer-types": {
      "Chediak-Higashi syndrome": [
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      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "51766e438ed59a060a000031",
    "question": "Name the factors required for selenoprotein synthesis in eukaryotes",
    "answer-types": {
      "eFSec": [
        "umls:gngm"
      ],
      "SLA/LP": [
        "umls:gngm"
      ],
      "Sec S": [
        "umls:bacs",
        "umls:aapp"
      ],
      "tRNASec": [
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      ],
      "SelD": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Sec synthase": [
        "umls:genf"
      ],
      "SECp43": [
        "umls:bacs",
        "umls:aapp"
      ],
      "SECIS element": [],
      "SBP2": [
        "umls:gngm"
      ],
      "SPS2": [
        "umls:gngm"
      ],
      "SPS1": [
        "umls:gngm"
      ],
      "(L30)": [
        "umls:gngm"
      ],
      "PSTK": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:genf": 2,
      "umls:bacs": 2,
      "umls:gngm": 7,
      "umls:aapp": 3
    }
  },
  {
    "qid": "552435602c8b63434a000009",
    "question": "Which genes/proteins have been found to inhibit cyclin dependent kinase 4 (CDK4)?",
    "answer-types": {
      "p16INK4": [
        "umls:gngm"
      ],
      "MTS1": [
        "umls:gngm"
      ],
      "p18(Ink4c)": [
        "umls:bacs",
        "umls:aapp"
      ],
      "p27KIP1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "p16": [
        "umls:gngm"
      ],
      "p15": [
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      ],
      "p16INK4a": [
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      ],
      "CDKN2": [
        "umls:gngm"
      ],
      "p21(Waf1/Cip1/Sdi1)": [],
      "p15INK4B": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:bacs": 2,
      "umls:gngm": 6,
      "umls:aapp": 3
    }
  },
  {
    "qid": "54f21b69c409818c32000007",
    "question": "Which disorders are associated to mutated Hepcidin (HAMP)?",
    "answer-types": {
      "juvenile hemochromatosis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "550618f58e1671127b000007",
    "question": "Which protein is the main inhibitor of protein phosphatase 1 (PP1)?",
    "answer-types": {
      "inhibitor 1": [
        "umls:gngm"
      ],
      "PPI-1": [],
      "protein phosphatase inhibitor 1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "I1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 2,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56cdf5195795f9a73e000045",
    "question": "Which protein is required for Argonaute 2 recruitment to stress granules and P-bodies?",
    "answer-types": {
      "Hsp90": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "51487dead24251bc05000030",
    "question": "Which pharmacogenetic test is available for abacavir?",
    "answer-types": {
      "HLA B*5701 genotyping": []
    },
    "type-counts": {}
  },
  {
    "qid": "52e203bc98d0239505000011",
    "question": "Which are the most under-represented oligonucleotides in higher eukaryote genomes?",
    "answer-types": {
      "CG": [
        "umls:geoa"
      ],
      "(PuPy)n": [],
      "CTA/TAG": [],
      "TA": [
        "umls:hlca"
      ],
      "GCA/TGC": []
    },
    "type-counts": {
      "umls:hlca": 1,
      "umls:geoa": 1
    }
  },
  {
    "qid": "515df86a298dcd4e5100002e",
    "question": "List co-morbidities that may occur together with \"Stiff man Syndrome\"",
    "answer-types": {
      "insulin-dependent) diabetes mellitus (IDDM": [
        "umls:dsyn"
      ],
      "Insulin Dependent Diabetes Mellitus": [
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      ],
      "Grave\u0027s disease": [
        "umls:dsyn"
      ],
      "type I": [
        "umls:clas"
      ],
      "Breast Cancer": [
        "umls:neop"
      ],
      "Dementia": [
        "umls:mobd"
      ],
      "type I (insulin-dependent) diabetes mellitus (IDDM)": [
        "umls:clas"
      ]
    },
    "type-counts": {
      "umls:clas": 2,
      "umls:mobd": 1,
      "umls:neop": 1,
      "umls:dsyn": 3
    }
  },
  {
    "qid": "56be2570ef6e39474100000d",
    "question": "What personality traits can be evaluated with the Ten Item Personality Inventory.",
    "answer-types": {
      "conscientiousness": [
        "umls:menp"
      ],
      "openness": [
        "umls:spco"
      ],
      "neuroticism": [
        "umls:mobd"
      ],
      "extroversion": [
        "umls:menp"
      ],
      "agreeableness": [
        "umls:menp"
      ]
    },
    "type-counts": {
      "umls:mobd": 1,
      "umls:spco": 1,
      "umls:menp": 3
    }
  },
  {
    "qid": "5322d3cb9b2d7acc7e000010",
    "question": "Which are the enzymes involved in the control of tubulin acetylation?",
    "answer-types": {
      "Sirtuin 2": [
        "umls:gngm"
      ],
      "dTip60": [],
      "histone deacetylase 6": [
        "umls:enzy",
        "umls:aapp"
      ],
      "MEC-17": [
        "umls:gngm"
      ],
      "SIRT2 (Sirtuin 2)": [
        "umls:gngm"
      ],
      "HDAC6 (histone deacetylase 6)": [
        "umls:enzy",
        "umls:aapp"
      ],
      "HDAC6": [
        "umls:enzy",
        "umls:aapp"
      ],
      "SIRT2": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 3,
      "umls:gngm": 4,
      "umls:aapp": 3
    }
  },
  {
    "qid": "515de748298dcd4e51000023",
    "question": "List all approved indications for Glivec",
    "answer-types": {
      "Chronic myelogenous leukemia (CML)": [
        "umls:neop"
      ],
      "DFSP": [
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      ],
      "GIST": [
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      ],
      "CML": [
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      ],
      "Gastrointestinal stromal tumor (GIST)": [
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      ],
      "Chronic myelogenous leukemia": [
        "umls:neop"
      ],
      "Dermatofibrosarcoma protuberans (DFSP)": [
        "umls:neop"
      ],
      "Dermatofibrosarcoma protuberans": [
        "umls:neop"
      ],
      "Gastrointestinal stromal tumor": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:fngs": 1,
      "umls:neop": 8
    }
  },
  {
    "qid": "54dfbed11388e8454a000008",
    "question": "Which proteins induce inhibition of LINE-1 and Alu retrotransposition?",
    "answer-types": {
      "Aicardi-Goutières syndrome gene product SAMHD1": [],
      "human APOBEC3 proteins A to H": []
    },
    "type-counts": {}
  },
  {
    "qid": "53147b52e3eabad021000015",
    "question": "What is a benefit of being g6PD-deficient?",
    "answer-types": {
      "Increased resistance to malaria, reduces the risk of coronary diseases, beneficial effect in terms of longevity": []
    },
    "type-counts": {}
  },
  {
    "qid": "52bf1f2d03868f1b06000015",
    "question": "Which drug is benserazide usually co-administered with?",
    "answer-types": {
      "L-Dopa": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52bf19f703868f1b06000002",
    "question": "What is the inheritance pattern of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) caused by RYR2 mutations?",
    "answer-types": {
      "autosomal dominant": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "570917bccf1c325851000015",
    "question": "Do A-type lamins bind euchromatin or heterochromatin?",
    "answer-types": {
      "Both euchromatin and heterochromatin": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "5149aafcd24251bc05000045",
    "question": "Which are the available biomedical text mining tools for the detection of protein-protein interactions?",
    "answer-types": {
      "PPI finder": [],
      "Protopia": [],
      "LAITOR": [],
      "HAPPI": [
        "umls:elii",
        "umls:bacs",
        "umls:phsu"
      ],
      "eFIP": [],
      "Protein interaction information extraction system": [],
      "TafTalent": [],
      "PreBind": [],
      "Extracting Functional Impact of Phosphorylation": [],
      "PPInterFinder": [],
      "BioCreative Meta Server": [],
      "PIE": [
        "umls:bpoc"
      ],
      "GeneView": [],
      "PPIs": [
        "umls:enzy",
        "umls:aapp"
      ],
      "BioMap": [],
      "iHop": [
        "umls:topp"
      ],
      "Hidden Vector State model": [],
      "OntoGene": [],
      "Textomy": [],
      "Paired-PPI Finder": [],
      "STRING": [
        "umls:medd"
      ],
      "PolySearch": [],
      "OpenDMAP": []
    },
    "type-counts": {
      "umls:elii": 1,
      "umls:enzy": 1,
      "umls:bpoc": 1,
      "umls:medd": 1,
      "umls:topp": 1,
      "umls:bacs": 1,
      "umls:aapp": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "5519a7d5622b194345000015",
    "question": "Which is the most abundant membrane protein on Earth?",
    "answer-types": {
      "Light-harvesting pigment-protein complex of Photosystem II": [],
      "LHCII": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "52fe4ad52059c6d71c000077",
    "question": "Which histone modifications are associated with constitutive heterochromatin?",
    "answer-types": {
      "H4K20 trimethylation": [],
      "H3S10 phosphorylation": [
        "umls:moft"
      ],
      "H3K79 methylation": [],
      "H3K9 trimethylation": []
    },
    "type-counts": {
      "umls:moft": 1
    }
  },
  {
    "qid": "51600ab3298dcd4e51000036",
    "question": "Which are the most commonly reported pathological states associated with the formation of DNA G-quadruplexes?",
    "answer-types": {
      "acute myeloid leukemia": [
        "umls:neop"
      ],
      "Amyotrophic lateral sclerosis (ALS)": [
        "umls:ftcn"
      ],
      "FTD": [
        "umls:dsyn"
      ],
      "frontotemporal dementia (FTD)": [
        "umls:dsyn"
      ],
      "ALS": [
        "umls:dsyn"
      ],
      "frontotemporal dementia": [
        "umls:dsyn"
      ],
      "Amyotrophic lateral sclerosis": [
        "umls:dsyn"
      ],
      "fibrosis": [
        "umls:patf"
      ],
      "Alzheimer\u0027s disease": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:ftcn": 1,
      "umls:patf": 1,
      "umls:neop": 1,
      "umls:dsyn": 6
    }
  },
  {
    "qid": "56c1f000ef6e394741000037",
    "question": "Which drugs are included in TAS-102?",
    "answer-types": {
      "tipiracil": [
        "umls:orch",
        "umls:phsu"
      ],
      "trifluridine": [
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        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:orch": 1,
      "umls:phsu": 2
    }
  },
  {
    "qid": "52f21e8f2059c6d71c00000c",
    "question": "What is the most probable defect underlying triple negative breast cancer?",
    "answer-types": {
      "BRCA1 dysfunction": []
    },
    "type-counts": {}
  },
  {
    "qid": "5147c8a6d24251bc05000027",
    "question": "Which enzyme is deficient in Krabbe disease?",
    "answer-types": {
      "also known as globoid-cell leukodystrophy). This leads to accumulation of psychosine (galactosylsphingosine": [],
      "Galactocerebrosidase is an enzyme that is deficient in Krabbe disease (also known as globoid-cell leukodystrophy). This leads to accumulation of psychosine (galactosylsphingosine) primarily in oligodendrocytes.": [],
      "Galactocerebrosidase is an enzyme that is deficient in Krabbe disease": []
    },
    "type-counts": {}
  },
  {
    "qid": "52f65bf02059c6d71c000026",
    "question": "Which deiodinase polymorphisms are implicated in arterial hypertension?",
    "answer-types": {
      "DIO 2 Thr92Ala": [],
      "rs7140952": []
    },
    "type-counts": {}
  },
  {
    "qid": "515db20e298dcd4e51000014",
    "question": "What are the current treatments for generalised anxiety disorder in teenagers?",
    "answer-types": {
      "SSRI": [
        "umls:phsu"
      ],
      "CBT": [
        "umls:topp"
      ],
      "group treatment": [
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      ],
      "manualised cognitive-behavioural therapy, FRIENDS": [],
      "Cognitive-behavioral treatment": [
        "umls:topp"
      ],
      "Cognitive-behavioral treatment (CBT)": [
        "umls:topp"
      ],
      "Sertraline": [
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        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:topp": 4,
      "umls:phsu": 2
    }
  },
  {
    "qid": "54f60ea05f206a0c06000009",
    "question": "Is there any genetic determinant of hair pigmentation that could be useful in forensic analyses?",
    "answer-types": {
      "Yes, there are at least 12 genes associated with human hair color variation such as: TYR, TYRP1, OCA2, SLC45A2, SLC24A5, MC1R, ASIP and KITLG.": []
    },
    "type-counts": {}
  },
  {
    "qid": "54cf6d40f693c3b16b00000e",
    "question": "Which drugs acting via bradykinin system are effective for treatment of ACE-inhibitor-induced angioedema?",
    "answer-types": {
      "icatibant": [
        "umls:aapp",
        "umls:phsu"
      ],
      "ecallantide": [
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:phsu": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "515bf6d6298dcd4e51000004",
    "question": "Which forms of cancer is the Tpl2 gene associated with?",
    "answer-types": {
      "nasopharyngeal carcinoma": [
        "umls:neop"
      ],
      "gastric adenocarcinoma": [
        "umls:neop"
      ],
      "colon adenocarcinoma": [
        "umls:neop"
      ],
      "colitis-associated cancer (CAC)": [],
      "CAC": [
        "umls:topp"
      ],
      "breast cancer": [
        "umls:neop"
      ],
      "T-cell neoplasia": [],
      "colitis-associated cancer": [],
      "Hodgkin lymphoma": [
        "umls:neop"
      ],
      "ADI prostate cancer": [],
      "Skin cancer": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 6,
      "umls:topp": 1
    }
  },
  {
    "qid": "530cf4fe960c95ad0c000007",
    "question": "What are the indications for hydrochlorothiazide?",
    "answer-types": {
      "diuretic": [
        "umls:phsu"
      ],
      "hypertension": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "52bf1cb303868f1b0600000b",
    "question": "What hand deformities do patients with Apert syndrome present with?",
    "answer-types": {
      "long and ring fingers": [],
      "simple syndactyly of the fourth web space": [],
      "intrinsic muscle anomalies": [],
      "short thumb with radial clinodactyly": [],
      "complex syndactyly with bony fusion involving the index": [],
      "symphalangism": [
        "umls:cgab"
      ],
      "extrinsic tendon insertions": [],
      "neurovascular bundles": [
        "umls:bpoc"
      ],
      "polydactyly": [
        "umls:cgab"
      ]
    },
    "type-counts": {
      "umls:cgab": 2,
      "umls:bpoc": 1
    }
  },
  {
    "qid": "51631154298dcd4e5100004e",
    "question": "What disease is Velcade (bortezomib) mainly used for?",
    "answer-types": {
      "multiple myeloma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 1
    }
  },
  {
    "qid": "5539029cbc4f83e828000012",
    "question": "Which genes are thought to be involved in medulloblastoma development?",
    "answer-types": {
      "CREBBP": [
        "umls:gngm"
      ],
      "TGIF2": [
        "umls:gngm"
      ],
      "MYT1L": [
        "umls:gngm"
      ],
      "PCDH10": [
        "umls:gngm"
      ],
      "RASSF1A": [
        "umls:gngm"
      ],
      "PTCH1": [
        "umls:gngm"
      ],
      "IGF2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "PTEN": [
        "umls:gngm"
      ],
      "BMI1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "HIC1": [
        "umls:gngm"
      ],
      "CASP8": [
        "umls:enzy",
        "umls:aapp"
      ],
      "NFIA": [
        "umls:gngm"
      ],
      "NFIB": [
        "umls:gngm"
      ],
      "SUFU": [
        "umls:gngm"
      ],
      "MYC": [
        "umls:bacs",
        "umls:aapp"
      ],
      "OTX2": [
        "umls:gngm"
      ],
      "TEAD1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:bacs": 3,
      "umls:gngm": 13,
      "umls:aapp": 4
    }
  },
  {
    "qid": "52fb78572059c6d71c000067",
    "question": "What is the prevalence of short QT syndrome?",
    "answer-types": {
      "0.01% -0.1%": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "5300aad02059c6d71c000080",
    "question": "Which sports have a risk for commotio cordis?",
    "answer-types": {
      "hockey": [
        "umls:dora"
      ],
      "soccer": [
        "umls:dora"
      ],
      "cricket": [
        "umls:euka"
      ],
      "baseball": [
        "umls:dora"
      ],
      "football": [
        "umls:dora"
      ],
      "lacrosse": [
        "umls:dora"
      ]
    },
    "type-counts": {
      "umls:dora": 5,
      "umls:euka": 1
    }
  },
  {
    "qid": "55181d1e6487737b43000008",
    "question": "What are the breath test biomarkers of pulmonary tuberculosis",
    "answer-types": {
      "nitric oxide": [
        "umls:inch",
        "umls:bacs",
        "umls:phsu"
      ],
      "volatile organic compounds": [
        "umls:orch"
      ],
      "hydrogen peroxide": [
        "umls:inch",
        "umls:irda",
        "umls:phsu"
      ],
      "end products of lipid peroxidation": [],
      "urea": [
        "umls:orch",
        "umls:bacs",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:inch": 2,
      "umls:irda": 1,
      "umls:orch": 2,
      "umls:bacs": 2,
      "umls:phsu": 3
    }
  },
  {
    "qid": "553e1aa5a3cf796f71000003",
    "question": "What types of DNA mutations are induced by 2-hydroxy-dATP (2-OH-dATP)?",
    "answer-types": {
      "tandem (CC --\u003e TT) mutations": [
        "umls:orch",
        "umls:phsu"
      ],
      "G:C --\u003e T:A transversions": [],
      "A:T --\u003e C:G mutations": [],
      "CC --\u003e TT": [],
      "G:C --\u003e A:T transitions": [],
      "tandem": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "56c08702ef6e394741000024",
    "question": "Which diseases can be treated with Afamelanotide?",
    "answer-types": {
      "acne vulgaris": [
        "umls:dsyn"
      ],
      "erythropoietic protoporphyria": [
        "umls:dsyn"
      ],
      "ctinic keratoses": [],
      "nonmelanoma skin cancer": [
        "umls:neop"
      ],
      "vitiligo": [
        "umls:dsyn"
      ],
      "Hailey-Hailey disease": [
        "umls:dsyn"
      ],
      "polymorphic light eruption": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:neop": 1,
      "umls:dsyn": 5
    }
  },
  {
    "qid": "56c1f034ef6e394741000050",
    "question": "List features of the Perry syndrome.",
    "answer-types": {
      "parkinsonism": [
        "umls:dsyn"
      ],
      "central hypoventilation": [
        "umls:fndg"
      ],
      "weight loss": [
        "umls:fndg"
      ],
      "depression": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:mobd": 1,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54cf45e7f693c3b16b00000a",
    "question": "Which is the main calcium binding protein of the sarcoplasmic reticulum?",
    "answer-types": {
      "Calsequestrin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "casq": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "571f5d3e0fd6f91b6800000a",
    "question": "For which diseases members of the 2-aminobenzamide class of histone deacetylase (HDAC) inhibitors show promise as therapeutics?",
    "answer-types": {
      "Friedreich\u0027s ataxia (FRDA)": [
        "umls:dsyn"
      ],
      "Friedreich\u0027s ataxia": [
        "umls:dsyn"
      ],
      "FRDA": [
        "umls:dsyn"
      ],
      "Huntington\u0027s disease": [
        "umls:dsyn"
      ],
      "HD": [
        "umls:patf"
      ],
      "Huntington\u0027s disease (HD)": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:dsyn": 5
    }
  },
  {
    "qid": "52fc94db2059c6d71c000074",
    "question": "List anti-amyloid-beta monoclonal antibodies that have been investigated in clinical trials for treatment of Alzheimer disease.",
    "answer-types": {
      "Gantenerumab": [
        "umls:imft",
        "umls:phsu"
      ],
      "Ponezumab": [
        "umls:imft",
        "umls:phsu"
      ],
      "Solanezumab": [
        "umls:imft",
        "umls:aapp",
        "umls:phsu"
      ],
      "Bapineuzumab": [
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:imft": 3,
      "umls:aapp": 2,
      "umls:phsu": 4
    }
  },
  {
    "qid": "516e5f25298dcd4e5100007d",
    "question": "Which anticancer drugs target human topoisomerase II?",
    "answer-types": {
      "m-AMSA": [
        "umls:orch",
        "umls:phsu"
      ],
      "VM-26": [
        "umls:orch",
        "umls:phsu"
      ],
      "Etoposide": [
        "umls:orch",
        "umls:phsu"
      ],
      "Aclarubicin": [
        "umls:antb",
        "umls:orch"
      ],
      "Amsacrine": [
        "umls:orch",
        "umls:phsu"
      ],
      "Etoposide (VP-16)": [
        "umls:orch",
        "umls:phsu"
      ],
      "Doxorubicin": [
        "umls:antb",
        "umls:orch"
      ],
      "Daunorubicin": [
        "umls:antb",
        "umls:orch"
      ],
      "Amsacrine (m-AMSA)": [
        "umls:orch",
        "umls:phsu"
      ],
      "VP-16": [
        "umls:orch",
        "umls:phsu"
      ],
      "Teniposide (VM-26)": [
        "umls:orch",
        "umls:phsu"
      ],
      "Teniposide": [
        "umls:orch",
        "umls:phsu"
      ],
      "Mitoxantrone": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:antb": 3,
      "umls:orch": 13,
      "umls:phsu": 10
    }
  },
  {
    "qid": "52fc8b772059c6d71c00006e",
    "question": "Which are the known inhibitors of the TPL2/MAP3K8 protein?",
    "answer-types": {
      "Indazoles": [
        "umls:orch"
      ],
      "Thieno[3,2-d]pyrimidines and thieno[2,3-c]pyridine": [],
      "Quinoline-3-carbonitrile derivatives (8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-4-ylmethyl)-amino]-quinoline-3-carbonitriles": [],
      "8-bromo-4-(3-chloro-4-fluorophenylamino)-6-[(1-methyl-1H-imidazol-4-yl)methylamino]quinoline-3-carbonitrile; 4-alkylamino-[1,7]naphthyridine-3-carbonitrile; 1,7-naphthyridine-3-carbonitriles)": [],
      "Honokiol": [
        "umls:orch",
        "umls:phsu"
      ],
      "Quinoline-3-carbonitrile derivatives": [],
      "8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-4-ylmethyl": []
    },
    "type-counts": {
      "umls:orch": 2,
      "umls:phsu": 1
    }
  },
  {
    "qid": "54ede95c94afd6150400000a",
    "question": "What is the mode of inheritance in Fanconi anemia?",
    "answer-types": {
      "Autosomal recessive, except for FANCB, which is X-linked.": []
    },
    "type-counts": {}
  },
  {
    "qid": "52f896d62059c6d71c000046",
    "question": "What memory problems are reported in the \" Gulf war syndrome\"",
    "answer-types": {
      "memory loss": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:mobd": 1
    }
  },
  {
    "qid": "553fca6054168f6c79000002",
    "question": "Which proteins compose the error prevention GO (8-oxo-G) system in Pseudomonas putida?",
    "answer-types": {
      "MutM": [
        "umls:gngm"
      ],
      "MutY": [
        "umls:enzy",
        "umls:aapp"
      ],
      "MutT": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:gngm": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "52ee065d98d0239505000033",
    "question": "List five applications of machine learning algorithms in medical diagnosis.",
    "answer-types": {
      "Parkinson\u0027s disease": [
        "umls:dsyn"
      ],
      "Microarray classification": [],
      "Mass spectral proteomics": [],
      "Brain glioma progression": [],
      "Lymph disease classification": []
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "56c04412ef6e39474100001b",
    "question": "Which molecule is targeted by Daratumumab?",
    "answer-types": {
      "CD38": [
        "umls:imft",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52f899952059c6d71c00004b",
    "question": "Which mutation is associated with PLMS (periodic limb movements in sleep)?",
    "answer-types": {
      "missense substitution, Met1Val (M1V), in the DCX gene.": [],
      "M1V": [
        "umls:fndg"
      ],
      "missense substitution, Met1Val": []
    },
    "type-counts": {
      "umls:fndg": 1
    }
  },
  {
    "qid": "53161545b166e2b806000002",
    "question": "Which DNA repair system is involved in HNPCC?",
    "answer-types": {
      "In HNPCC, the mismatch DNA repair system is involved.": []
    },
    "type-counts": {}
  },
  {
    "qid": "56ae6e650a360a5e4500000e",
    "question": "Mention the only available genomics and developmental transcriptomics resource for the urochordate Oikopleura dioica",
    "answer-types": {
      "OikoBase": []
    },
    "type-counts": {}
  },
  {
    "qid": "56d094f33975bb303a000012",
    "question": "List functional roles of the FtsZ protein.",
    "answer-types": {
      "cell elongation": [
        "umls:celf"
      ],
      "cell division": [
        "umls:celf"
      ],
      "GTPase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "bacterial cytoskeleton": []
    },
    "type-counts": {
      "umls:celf": 2,
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "550e866271445a662f000005",
    "question": "Intetumumab has been tested in clinical trials for treatment of which cancers?",
    "answer-types": {
      "prostate cancer": [
        "umls:neop"
      ],
      "angiosarcoma": [
        "umls:neop"
      ],
      "melanoma": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 3
    }
  },
  {
    "qid": "5314bd7ddae131f847000006",
    "question": "Which hormone receptor function is altered in patients with Donohue syndrome?",
    "answer-types": {
      "insulin": [
        "umls:horm",
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:horm": 1,
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56acc7ca0a360a5e45000002",
    "question": "List available tools for genomic visualisation in comparative genomics",
    "answer-types": {
      "Insyght": [],
      "Sockeye": [
        "umls:fish"
      ],
      "Genomicus": []
    },
    "type-counts": {
      "umls:fish": 1
    }
  },
  {
    "qid": "515ffc2b298dcd4e51000035",
    "question": "Which species may be used for the biotechnological production of itaconic acid?",
    "answer-types": {
      "Ustilago maydis": [
        "umls:fngs"
      ],
      "Aspergillus niger": [
        "umls:fngs"
      ],
      "Aspergillus terreus": [
        "umls:fngs"
      ]
    },
    "type-counts": {
      "umls:fngs": 3
    }
  },
  {
    "qid": "5321badd9b2d7acc7e00000a",
    "question": "Which types of cancer can be recognized and treated by the use of immunotherapy?",
    "answer-types": {
      "Prostate tumor": [
        "umls:neop"
      ],
      "Lung Cancer": [
        "umls:neop"
      ],
      "Head Cancer": [
        "umls:neop"
      ],
      "Melanoma": [
        "umls:neop"
      ],
      "Colorectal Cancer": [
        "umls:neop"
      ],
      "Pancreatic Cancer": [
        "umls:neop"
      ],
      "Breast Cancer": [
        "umls:neop"
      ],
      "Leukaemia": [
        "umls:neop"
      ]
    },
    "type-counts": {
      "umls:neop": 8
    }
  },
  {
    "qid": "52e8e9d298d0239505000022",
    "question": "Which are the subtypes of Pfeiffer syndrome?",
    "answer-types": {
      "Type II (2)": [
        "umls:clas"
      ],
      "Type III": [
        "umls:clas"
      ],
      "1": [
        "umls:qnco"
      ],
      "2": [
        "umls:qnco"
      ],
      "3": [
        "umls:qnco"
      ],
      "Type III (3)": [
        "umls:clas"
      ],
      "Type I": [
        "umls:clas"
      ],
      "Type II": [
        "umls:clas"
      ],
      "Type I (1)": [
        "umls:clas"
      ]
    },
    "type-counts": {
      "umls:clas": 6,
      "umls:qnco": 3
    }
  },
  {
    "qid": "55180ef46487737b43000006",
    "question": "What is the typical rash associated with gluten ?",
    "answer-types": {
      "dermatitis herpetiformis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "52fa74052059c6d71c00005a",
    "question": "Which are the newly identified DNA nucleases that can be used to treat thalassemia?",
    "answer-types": {
      "Transcription activator-like effector nucleases": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Zinc-finger nucleases": [
        "umls:enzy",
        "umls:aapp"
      ],
      "TALEN": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Transcription activator-like effector nucleases (TALEN)": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 4,
      "umls:aapp": 4
    }
  },
  {
    "qid": "5540eda30083d1bf0e000006",
    "question": "Which proteins constitute the methyl-directed mismatch repair system (MMR) in bacteria?",
    "answer-types": {
      "mutL": [
        "umls:enzy",
        "umls:aapp"
      ],
      "mutS": [
        "umls:enzy",
        "umls:aapp"
      ],
      "mutH": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:bacs": 1,
      "umls:aapp": 3
    }
  },
  {
    "qid": "51716e808ed59a060a00000b",
    "question": "Which is the vector of Louping ill virus?",
    "answer-types": {
      "Ixodes ricinus": [
        "umls:euka"
      ]
    },
    "type-counts": {
      "umls:euka": 1
    }
  },
  {
    "qid": "56cdf3745795f9a73e000039",
    "question": "Which are the main components of mTORC1?",
    "answer-types": {
      "mTOR": [
        "umls:enzy",
        "umls:aapp"
      ],
      "mLST8/GbetaL": [],
      "Raptor": [
        "umls:bird"
      ]
    },
    "type-counts": {
      "umls:bird": 1,
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "554101d0234c5a7c75000002",
    "question": "Which receptor(s) recognize lysosomal hydrolases in trans-Golgi network (TGN)?",
    "answer-types": {
      "lysosomal integral membrane protein (LIMP-2)": [
        "umls:gngm"
      ],
      "MPRs": [
        "umls:bpoc"
      ],
      "sortilin": [
        "umls:aapp"
      ],
      "mannose 6-phosphate receptors": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "lysosomal integral membrane protein": [
        "umls:gngm"
      ],
      "CI-MPR": [
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      ],
      "cation-independent mannose 6-phosphate receptor": [
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      ],
      "LIMP-2": [
        "umls:gngm"
      ],
      "mannose 6-phosphate receptors (MPRs)": [],
      "cation-independent mannose 6-phosphate receptor (CI-MPR)": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:bpoc": 1,
      "umls:rcpt": 1,
      "umls:gngm": 6,
      "umls:aapp": 2
    }
  },
  {
    "qid": "5508685b4b2a315d4100000a",
    "question": "List the diseases that can be treated using Vedolizumab.",
    "answer-types": {
      "Crohn\u0027s disease": [
        "umls:dsyn"
      ],
      "Ulcerative colitis": [
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      ]
    },
    "type-counts": {
      "umls:dsyn": 2
    }
  },
  {
    "qid": "53592c1e9a4572de6f000002",
    "question": "Which value of nuchal translucency thickness is set as the threshold for high-risk for Down Syndrome?",
    "answer-types": {
      "3mm": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "56f553e309dd18d46b000006",
    "question": "What is the function of the spliceosome complex?",
    "answer-types": {
      "The excision of introns from nascent eukaryotic transcripts is catalyzed by the spliceosome.": []
    },
    "type-counts": {}
  },
  {
    "qid": "553fac39c6a5098552000001",
    "question": "Which genes code for the alpha subunit of the DNA polymerase III in most Firmicutes?",
    "answer-types": {
      "dnaE": [
        "umls:aapp"
      ],
      "polC": [
        "umls:enzy",
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      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 2
    }
  },
  {
    "qid": "56cf4b623975bb303a00000a",
    "question": "List the neurotransmitters that are metabolized by MAOA.",
    "answer-types": {
      "norepinephrine": [
        "umls:orch",
        "umls:horm",
        "umls:phsu"
      ],
      "serotonin": [
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      ],
      "dopamine": [
        "umls:orch",
        "umls:bacs",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 3,
      "umls:horm": 1,
      "umls:bacs": 2,
      "umls:phsu": 2
    }
  },
  {
    "qid": "55450521bf90a13052000001",
    "question": "What is the effect of enamel matrix derivative on pulp regeneration?",
    "answer-types": {
      "increase of the osteogenic potential of hDPCs": []
    },
    "type-counts": {}
  },
  {
    "qid": "533c390bc45e13371400000b",
    "question": "What is an acceptable sequence coverage(depth) required for human whole-exome sequencing?",
    "answer-types": {
      "30x-60x": []
    },
    "type-counts": {}
  },
  {
    "qid": "531a3a58b166e2b806000037",
    "question": "To what extent does HPV vaccination reduce the risk for cervical cancer?",
    "answer-types": {
      "Cervical precancer and similar neoplasias were reduced by 84-100%": []
    },
    "type-counts": {}
  },
  {
    "qid": "5339edd6d6d3ac6a34000061",
    "question": "Which is the clinical meaning of the presence of delayed enhancement in patients with hypertrophic cardiomyopathy?",
    "answer-types": {
      "In patients with hypertrophic cardiomyopathy delayed enhancement is associated with heart failure symptoms and left ventricular systolic dysfunction and arrhythmic risk": []
    },
    "type-counts": {}
  },
  {
    "qid": "5156be17d24251bc05000086",
    "question": "What disease is mirtazapine predominantly used for?",
    "answer-types": {
      "major depression": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:mobd": 1
    }
  },
  {
    "qid": "516e5f10298dcd4e5100007c",
    "question": "Is cancer related to global DNA hypo or hypermethylation?",
    "answer-types": {
      "Global hypomethylation is coupled with focal hypermethylation at CpG islands": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "5540b9800083d1bf0e000002",
    "question": "Alpha-spectrin and beta-spectrin subunits form parallel or antiparallel heterodimers?",
    "answer-types": {
      "antiparallel": []
    },
    "type-counts": {}
  },
  {
    "qid": "516545a8298dcd4e51000056",
    "question": "Which is the protein (antigen) targeted by anti-Vel antibodies in the Vel blood group?",
    "answer-types": {
      "SMIM1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "514c3fd7d24251bc05000062",
    "question": "Intact macromolecular assemblies are analysed by advanced mass spectrometry. How large complexes (in molecular weight) have been studied?",
    "answer-types": {
      "2.3 megadalton": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "52bf1d6003868f1b0600000e",
    "question": "Which are the subtypes of Pfeiffer syndrome?",
    "answer-types": {
      "Type III": [
        "umls:clas"
      ],
      "Type I": [
        "umls:clas"
      ],
      "Type II": [
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      ]
    },
    "type-counts": {
      "umls:clas": 3
    }
  },
  {
    "qid": "56c1f01cef6e394741000044",
    "question": "What is targeted by Palbociclib?",
    "answer-types": {
      "epidermal growth factor receptor": [
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        "umls:rcpt",
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      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:rcpt": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "56b1f4300a360a5e4500001b",
    "question": "Which peptide plays a pivotal role in human cystatin C fibrillization?",
    "answer-types": {
      "LQVVR": []
    },
    "type-counts": {}
  },
  {
    "qid": "515c4f1f298dcd4e51000007",
    "question": "Which genes does thyroid hormone receptor beta1 regulate in the heart?",
    "answer-types": {
      "HCN4": [
        "umls:gngm"
      ],
      "alpha-MHC": [
        "umls:bacs",
        "umls:aapp"
      ],
      "β-MHC": [],
      "KCND2/3": [],
      "SERCA": [
        "umls:dsyn"
      ],
      "TRbeta1": []
    },
    "type-counts": {
      "umls:dsyn": 1,
      "umls:bacs": 1,
      "umls:gngm": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "52ffbddf2059c6d71c00007d",
    "question": "Which are the most under-represented oligonucleotides in higher eukaryote genomes?",
    "answer-types": {
      "Oligonucleotides containing CG and TA dinucleoides": []
    },
    "type-counts": {}
  },
  {
    "qid": "5325fdf0600967d132000001",
    "question": "What is the gold standard treatment for Iatrogenic male incontinence?",
    "answer-types": {
      "Artificial urethral sphincter": [
        "umls:medd"
      ],
      "AUS": [
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      ]
    },
    "type-counts": {
      "umls:medd": 1,
      "umls:geoa": 1
    }
  },
  {
    "qid": "5357b36cf1005d6b58000006",
    "question": "Which is the main CHEK2 genetic variant, thought to be involved in familial breast cancer?",
    "answer-types": {
      "CHEK2 1100delC mutation": []
    },
    "type-counts": {}
  },
  {
    "qid": "52f88d292059c6d71c000036",
    "question": "Which hormone abnormalities are common in Williams syndrome",
    "answer-types": {
      "Elevated TSH": [
        "umls:fndg"
      ],
      "GHD": [
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      ],
      "Calcitonin deficiency": [],
      "Elevated Oxytocin": [],
      "Elevated OT": [],
      "Elevated Cortisol": [
        "umls:fndg"
      ],
      "Growth Hormone deficiency": [
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      ],
      "Elevated Vasopressin": [],
      "Elevated AVP": [],
      "Low Thyroxine": [
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      ],
      "Elevated Prolactin": [
        "umls:fndg"
      ],
      "Low FT4": [],
      "Elevated Thyrotropin -": [
        "umls:fndg"
      ]
    },
    "type-counts": {
      "umls:fndg": 5,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "553f96191d53b76422000004",
    "question": "Which assays can be used for detecting DNA fragmentation resulting from programmed cell death (apoptosis)?",
    "answer-types": {
      "measurement of cytosolic histone-bound DNA fragments (cell death ELISA assays)": [],
      "terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling of DNA fragments": [],
      "electrophoresis of whole cell lysates": [],
      "centrifugation of whole cell lysates": [],
      "anti-DNA immunoelectron microscopy": [],
      "in situ end labeling (ISEL) of the genomic DNA in fragmented nuclei": [
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      ],
      "measurement of cytosolic histone-bound DNA fragments": [],
      "cell death ELISA assays": [],
      "in situ end labeling": [
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      ],
      "DAPI staining assay": [],
      "ISEL": [],
      "TUNEL": [
        "umls:mbrt"
      ],
      "terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling of DNA fragments (TUNEL)": [],
      "comet assay": [
        "umls:mbrt"
      ],
      "fluorescence correlation spectroscopy": [],
      "fluorescence correlation spectroscopy (FCS)": [],
      "FCS": [
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      ]
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    "type-counts": {
      "umls:irda": 1,
      "umls:mbrt": 4
    }
  },
  {
    "qid": "530f900ee3eabad021000003",
    "question": "Which hormone concentrations are altered in patients with the Allan–Herndon–Dudley syndrome?",
    "answer-types": {
      "Thyroid": [
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      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54e8c7220fc566b149000002",
    "question": "Where in the cell does the proteins S100A4 and p53 interact ?",
    "answer-types": {
      "nucleus": [
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      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "56bc932aac7ad1001900001c",
    "question": "Which molecule is targeted by Daratumumab?",
    "answer-types": {
      "CD38": [
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      ]
    },
    "type-counts": {
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      "umls:aapp": 1
    }
  },
  {
    "qid": "517194ef8ed59a060a000011",
    "question": "Which is the causative agent of malaria?",
    "answer-types": {
      "Plasmodium species": [
        "umls:euka"
      ],
      "Plasmodium spp.": []
    },
    "type-counts": {
      "umls:euka": 1
    }
  },
  {
    "qid": "53551206a0726bee57000001",
    "question": "What is the major adverse effect of adriamycin(doxorubicin)?",
    "answer-types": {
      "Cardiotoxicity": [
        "umls:inpo"
      ],
      "Cardiac toxicity": [
        "umls:inpo"
      ]
    },
    "type-counts": {
      "umls:inpo": 2
    }
  },
  {
    "qid": "56ffdc1ccf1c32585100000b",
    "question": "Which is the most common editing modification in eukaryotic mRNA?",
    "answer-types": {
      "A-to-I": [
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        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54de15f91388e8454a000002",
    "question": "Which are the APOBEC3 protein family members able to inhibit Vif-deficient HIV-1 replication?",
    "answer-types": {
      "APOBEC3DE": [
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      ],
      "APOBEC3F": [
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      ],
      "APOBEC3G": [
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      ],
      "APOBEC3A": [
        "umls:gngm"
      ],
      "APOBEC3H haplotypes II, V, and VII": []
    },
    "type-counts": {
      "umls:gngm": 4
    }
  },
  {
    "qid": "5306158358348c0f52000001",
    "question": "Which genetic defects are observed in Prader-Willi syndrome?",
    "answer-types": {
      "maternal chromosome 15 uniparental disomy": [
        "umls:irda"
      ],
      "monoallelic expression of the paternal alleles": [],
      "15q11-13 deletions of paternal origin": [],
      "rare imprinting mutations": []
    },
    "type-counts": {
      "umls:irda": 1
    }
  },
  {
    "qid": "56cae3eb5795f9a73e000021",
    "question": "What is the most likely age of diagnosis of Crohn\u0027s disease (CD)?",
    "answer-types": {
      "Crohn\u0027s disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals.": [],
      "Crohn\u0027s disease has a bimodal age distribution of disease onset diagnosis. The peaks": [],
      "20 and 50 years": [
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      ]
    },
    "type-counts": {
      "umls:fndg": 1
    }
  },
  {
    "qid": "5149af96d24251bc05000046",
    "question": "Which are the state-of-the-art computational tools for the prediction of gene fusion events?",
    "answer-types": {
      "Predictome": [],
      "MosaicFinder": [],
      "FusionDB": [],
      "Integrated method for Prediction of Protein-Protein Interactions": [],
      "InPrePPI": [],
      "STRING": [
        "umls:medd"
      ],
      "fdfBLAST": [],
      "PLEX": [
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      ],
      "Rosetta Stone method": [],
      "Phydbac2": []
    },
    "type-counts": {
      "umls:medd": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "5509bd6a1180f13250000002",
    "question": "What disease is small bowel lymphoma commonly associated with",
    "answer-types": {
      "Celiac disease": [
        "umls:dsyn"
      ],
      "Gluten Sensitive Enteropath": [],
      "gluten-associated enteropathy": [],
      "Non tropical spru": [],
      "CELIAC SPRU": []
    },
    "type-counts": {
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    }
  },
  {
    "qid": "54e0d7471388e8454a000015",
    "question": "Which molecule is targeted by a monoclonal antibody Secukinumab?",
    "answer-types": {
      "interleukin-17A": [
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    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54f9c40ddd3fc62544000001",
    "question": "Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?",
    "answer-types": {
      "CaN": [
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      ],
      "Calcineurin": [
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      "phosphatase 2b": [
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      ]
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    "type-counts": {
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      "umls:enzy": 1,
      "umls:geoa": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "532ff917d6d3ac6a34000038",
    "question": "What histone trimethylation has been associated to RNA splicing?",
    "answer-types": {
      "H3K36me3": []
    },
    "type-counts": {}
  },
  {
    "qid": "569e7721ceceede94d000001",
    "question": "What was the purpose of the FANTOM4 project?",
    "answer-types": {
      "Better understand the transcriptional network that regulates macrophage differentiation": []
    },
    "type-counts": {}
  },
  {
    "qid": "56e460d051531f7e33000019",
    "question": "List the results of mutated casein kinase 1 epsilon.",
    "answer-types": {
      "effects on cell adhesion": [],
      "abnormal entrainment to light cycles": [],
      "short circadian period": [],
      "potentiated resetting responses to light": [],
      "NREM sleep architecture": [],
      "effects on cell migration": [],
      "REM sleep amount": [],
      "timing of sleep": []
    },
    "type-counts": {}
  },
  {
    "qid": "5156be04d24251bc05000085",
    "question": "What gene test is recommended for clopidogrel?",
    "answer-types": {
      "CYP2C19 genotyping": []
    },
    "type-counts": {}
  },
  {
    "qid": "56a24dfffe92d6fd19000002",
    "question": "What is the role of eteplirsen in DMD patients?",
    "answer-types": {
      "skipping of dystrophin exon 51": []
    },
    "type-counts": {}
  },
  {
    "qid": "514a11add24251bc05000054",
    "question": "Which diseases can Oncotype DX be used for?",
    "answer-types": {
      "colon cancer": [
        "umls:neop"
      ],
      "breast cancer": [
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      ]
    },
    "type-counts": {
      "umls:neop": 2
    }
  },
  {
    "qid": "5165932e298dcd4e51000059",
    "question": "Which are the DNA (cytosine-5-)-methyltransferases inhibitors?",
    "answer-types": {
      "DZCyt": [],
      "procaine": [
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      ],
      "zebularine": [
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      ],
      "5-aza-CdR": [],
      "FdC": [
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      ],
      "Vidaza®": [
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        "umls:phsu"
      ],
      "2-(1H)-pyrimidinone riboside": [],
      "hydralazine": [
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      ],
      "5-azacytidine": [
        "umls:nnon",
        "umls:phsu"
      ],
      "Decitabine": [
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      ],
      "2-(1H)-pyrimidinone": [
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      ],
      "5-aza-CR": [],
      "5,6-dihydro-5-azacytosine": [
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      ],
      "ZCyt": [],
      "Dacogen®": [
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      "4\u0027-thio-2\u0027-deoxycytidine": [
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      ],
      "Psammaplin A": [
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      ],
      "procainamide": [
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      ],
      "5-fluorodeoxycytidine": [
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      ],
      "RSC133": [
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      ],
      "5-azacytosine": [
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      ],
      "zebularine aglycon": [],
      "5-azadeoxycytidine": [
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        "umls:phsu"
      ],
      "5-aza-2\u0027-deoxycytidine": [
        "umls:nnon",
        "umls:phsu"
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    },
    "type-counts": {
      "umls:nnon": 9,
      "umls:orch": 8,
      "umls:dsyn": 1,
      "umls:bacs": 1,
      "umls:phsu": 13
    }
  },
  {
    "qid": "5131bef65274a5fb07000008",
    "question": "Which are the main histone modifications associated with enhancers?",
    "answer-types": {
      "Histone 3 lysine 4 di-methylation (H3K4me2)": [],
      "Histone 3 lysine 4 di-methylation": [],
      "Histone 3 lysine 4 mono-methylation (H3K4me1)": [],
      "H3K4me1": [
        "umls:aapp"
      ],
      "H3K4me2": [
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      ],
      "Histone 3 lysine 4 mono-methylation": []
    },
    "type-counts": {
      "umls:aapp": 2
    }
  },
  {
    "qid": "5324ce779b2d7acc7e00001e",
    "question": "Which drug is considered as the first line treatment of fibromyalgia?",
    "answer-types": {
      "Pregabalin": [
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        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "56b773a96e3f8eaf4c000003",
    "question": "With which complexes is the protein SUS1 associated?",
    "answer-types": {
      "TREX-2 complex": [
        "umls:celc"
      ],
      "SAGA complex": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 2
    }
  },
  {
    "qid": "5516757c46478f2f2c000008",
    "question": "Which are the main NMD factors in Saccharomyces cerevisiae?",
    "answer-types": {
      "Upf1p": [],
      "Upf3p": [],
      "Nmd2p": []
    },
    "type-counts": {}
  },
  {
    "qid": "5160412d298dcd4e5100003c",
    "question": "Which histone marks are deposited by Set7?",
    "answer-types": {
      "H3K4 monomethylation": [],
      "H4K20 monomethylation": []
    },
    "type-counts": {}
  },
  {
    "qid": "56c3184050c68dd416000003",
    "question": "What is the indication for isradipine?",
    "answer-types": {
      "Hypertension": [
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      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "54df6ed91388e8454a000007",
    "question": "List non-surgical treatment modalities that are included in the Stupp protocol.",
    "answer-types": {
      "radiotherapy": [
        "umls:inpr"
      ],
      "chemotherapy": [
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      ]
    },
    "type-counts": {
      "umls:inpr": 1,
      "umls:topp": 1
    }
  },
  {
    "qid": "54e22b62ae9738404b000011",
    "question": "Which genes are associated with Ehlers-Danlos syndrome type I/II?",
    "answer-types": {
      "COL5A1": [
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      ],
      "COL5A2": [
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      ]
    },
    "type-counts": {
      "umls:gngm": 2
    }
  },
  {
    "qid": "551adceb622b194345000018",
    "question": "Which factors are considered in the ABCD2 score?",
    "answer-types": {
      "Duration of symptoms": [
        "umls:tmco"
      ],
      "Clinical features": [
        "umls:fndg"
      ],
      "Blood pressure": [
        "umls:orgf"
      ],
      "Diabetes": [
        "umls:dsyn"
      ],
      "Age": [
        "umls:orga"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:orga": 1,
      "umls:orgf": 1,
      "umls:dsyn": 1,
      "umls:tmco": 1
    }
  },
  {
    "qid": "55421398ccca0ce74b000001",
    "question": "What type of DNA repair pathways is initiated by AlkA glycosylase?",
    "answer-types": {
      "base excision repair": [
        "umls:genf"
      ],
      "base excision repair (BER) pathway": [
        "umls:genf"
      ],
      "BER": [
        "umls:plnt"
      ]
    },
    "type-counts": {
      "umls:plnt": 1,
      "umls:genf": 2
    }
  },
  {
    "qid": "532f0b2cd6d3ac6a3400002c",
    "question": "Which are the musculoskeletal manifestations of Marfan syndrome?",
    "answer-types": {
      "arachnodactyly": [
        "umls:cgab"
      ],
      "otto pelvis": [
        "umls:anab"
      ],
      "scoliosis": [
        "umls:anab"
      ],
      "dural ectasia": [
        "umls:fndg"
      ],
      "dolichostenomelia": [
        "umls:cgab"
      ],
      "ligamentous laxity": [
        "umls:patf"
      ],
      "protrusio acetabuli": [
        "umls:anab"
      ],
      "pectus excavatum and carinatum": [
        "umls:anab"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:patf": 1,
      "umls:cgab": 2,
      "umls:anab": 4
    }
  },
  {
    "qid": "5512c1ee6a8cde6b72000009",
    "question": "Which proteins are the different isoforms of the p38 MAP kinase?",
    "answer-types": {
      "p38beta": [
        "umls:gngm"
      ],
      "p38delta": [
        "umls:enzy",
        "umls:aapp"
      ],
      "p38alpha": [
        "umls:gngm"
      ],
      "p38gamma": [
        "umls:gngm"
      ],
      "p38δ": [
        "umls:enzy",
        "umls:aapp"
      ],
      "p38γ": [
        "umls:gngm"
      ],
      "p38β": [
        "umls:gngm"
      ],
      "p38α": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:gngm": 6,
      "umls:aapp": 2
    }
  },
  {
    "qid": "515db70c298dcd4e51000017",
    "question": "What are the reported adverse effects of gabapentin used in children?",
    "answer-types": {
      "irritability": [
        "umls:fndg"
      ],
      "hyperactivity": [
        "umls:mobd"
      ],
      "drowsiness": [
        "umls:fndg"
      ],
      "explosive outbursts": [],
      "oppositional behavior": [
        "umls:sosy"
      ],
      "Skin reactions": [
        "umls:clna"
      ],
      "aggression": [
        "umls:inbe"
      ],
      "sedation": [
        "umls:fndg"
      ],
      "lassitude": [
        "umls:sosy"
      ],
      "agitation": [
        "umls:sosy"
      ],
      "Dizziness": [
        "umls:sosy"
      ],
      "Somnolence": [
        "umls:fndg"
      ],
      "defiance": [
        "umls:inbe"
      ],
      "malaise": [
        "umls:sosy"
      ]
    },
    "type-counts": {
      "umls:fndg": 4,
      "umls:sosy": 5,
      "umls:clna": 1,
      "umls:inbe": 2,
      "umls:mobd": 1
    }
  },
  {
    "qid": "54fb5c69d176fff445000003",
    "question": "Which are the 3 basic transcription factors that have been used for the direct reprogramming of fibroblasts into cardiomyocytes or cardiomyocyte like-cells?",
    "answer-types": {
      "Mef2c": [
        "umls:gngm"
      ],
      "Gata4": [
        "umls:gngm"
      ],
      "Tbx5": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 3
    }
  },
  {
    "qid": "530cf4c54a5037880c000008",
    "question": "What is the name of Bruton\u0027s tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?",
    "answer-types": {
      "Ibrutinib": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "54f2210164850a5854000001",
    "question": "How many disulfide bridges has the protein hepcidin got?",
    "answer-types": {
      "Hepcidin contains eight cysteine residues that form four disulfide bridges": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "5357b9bcf1005d6b58000008",
    "question": "Which are the major intramolecular phosphorylation sites of human Chk2 involved in cell cycle control?",
    "answer-types": {
      "S33/35": [],
      "T68": [
        "umls:bact"
      ],
      "S19": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1,
      "umls:bact": 1
    }
  },
  {
    "qid": "5542644fed966d112c000004",
    "question": "Which are the methods for in silico prediction of the origin of replication (ori) among bacteria?",
    "answer-types": {
      "localization of CtrA binding sites": [],
      "localization of IHF binding sites": [],
      "DnaA boxes": [],
      "localization of other consensus origin recognition box": [],
      "localization of other consensus origin recognition box (ORB) sequences": [],
      "localization of dnaA binding sites (DnaA boxes)": [],
      "localization of dnaA binding sites": [],
      "Z curve analysis": [],
      "the gene order around the ori": [],
      "comparative genomics": [],
      "localization of cell division cycle": [],
      "localization of cell division cycle (cdc6) gene": [],
      "gene distribution in leading versus lagging strand": [],
      "localization of other boundary genes": [],
      "cdc6": [
        "umls:bacs",
        "umls:aapp"
      ],
      "GC skew analysis": [],
      "dnaA gene location": [],
      "ORB": [
        "umls:blor"
      ]
    },
    "type-counts": {
      "umls:blor": 1,
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "55242d512c8b63434a000006",
    "question": "Which receptors can be evaluated with the [18F]altanserin?",
    "answer-types": {
      "5-HT2A": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "550316a6e9bde69634000029",
    "question": "Which diseases have been associated with the PTPN22 620W allele?",
    "answer-types": {
      "granulomatosis with polyangiitis": [
        "umls:dsyn"
      ],
      "Wegener\u0027s granulomatosis (granulomatosis with polyangiitis)": [
        "umls:dsyn"
      ],
      "type 1 diabetes": [
        "umls:dsyn"
      ],
      "systemic lupus erythematosus": [
        "umls:dsyn"
      ],
      "Hashimoto thyroiditis": [
        "umls:dsyn"
      ],
      "seropositive rheumatoid arthritis": [
        "umls:dsyn"
      ],
      "Wegener\u0027s granulomatosis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 7
    }
  },
  {
    "qid": "513f45abbee46bd34c000013",
    "question": "Which extra thyroid tissues have thyrotropin (TSH) receptors?",
    "answer-types": {
      "fibrotic tissue": [
        "umls:fndg"
      ],
      "adipose tissue": [
        "umls:tisu"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:tisu": 1
    }
  },
  {
    "qid": "56ddbbaf51531f7e33000009",
    "question": "Which histone modifications distinguish between promoters and enhancers?",
    "answer-types": {
      "H3K27ac enrichment": [],
      "H3K27me3 depletion": []
    },
    "type-counts": {}
  },
  {
    "qid": "54e0ba781388e8454a000011",
    "question": "Where is the metaxin complex localized?",
    "answer-types": {
      "To the outer mitochondrial membrane.": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "517843638ed59a060a000036",
    "question": "What are the major classes of retrotransposons active in the human genome?",
    "answer-types": {
      "LINE-1": [
        "umls:nnon",
        "umls:bacs"
      ],
      "L1": [
        "umls:fndg"
      ],
      "Alu": [
        "umls:nnon",
        "umls:bacs"
      ],
      "SVA": [
        "umls:bpoc"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:nnon": 2,
      "umls:bpoc": 1,
      "umls:bacs": 2
    }
  },
  {
    "qid": "55031286e9bde6963400001b",
    "question": "Which are the clinical characteristics of Diamond-Blackfan anemia?",
    "answer-types": {
      "Predisposition to cancer": [
        "umls:fndg"
      ],
      "Congenital anomalies": [
        "umls:cgab"
      ],
      "Red cell aplasia": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:fndg": 1,
      "umls:cgab": 1,
      "umls:dsyn": 1
    }
  },
  {
    "qid": "5335f053d6d3ac6a34000055",
    "question": "How can the expression of SerH3 immobilization antigen be regulated?",
    "answer-types": {
      "Temperature regulation": [
        "umls:topp"
      ]
    },
    "type-counts": {
      "umls:topp": 1
    }
  },
  {
    "qid": "533ec7abc45e133714000015",
    "question": "Which factors play a role in promoter proximal pausing of RNA polymerase II?",
    "answer-types": {
      "NELF": [
        "umls:gngm"
      ],
      "DSIF": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:gngm": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54ecb640445c3b5a5f000001",
    "question": "Which are the main clinical features of Fanconi anemia?",
    "answer-types": {
      "increased risk of malignancies": [
        "umls:fndg"
      ],
      "congenital abnormalities": [
        "umls:cgab"
      ],
      "cellular hypersensitivity to DNA crosslinking agents": [
        "umls:fndg"
      ],
      "defective haemopoiesis": []
    },
    "type-counts": {
      "umls:fndg": 2,
      "umls:cgab": 1
    }
  },
  {
    "qid": "56f6c11109dd18d46b00000e",
    "question": "Which is the receptor for the immunosuppressive drug cyclosporin A (CsA)?",
    "answer-types": {
      "cyclophilin": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "513f3d1fbee46bd34c000010",
    "question": "Which drugs may interfere thyroxine absorption?",
    "answer-types": {
      "Calcium carbonate": [
        "umls:inch",
        "umls:phsu"
      ],
      "ferrous sulphate": [
        "umls:inch",
        "umls:phsu"
      ],
      "bile acide sequestrant": [],
      "proton pump inhibithors": [],
      "sevelamer": [
        "umls:orch",
        "umls:phsu"
      ],
      "raloxifene": [
        "umls:orch",
        "umls:phsu"
      ],
      "chromium picolinate": [
        "umls:orch",
        "umls:phsu"
      ],
      "aluminium-containing antacids": [
        "umls:inch",
        "umls:phsu"
      ],
      "sucralfate": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:inch": 3,
      "umls:orch": 4,
      "umls:phsu": 7
    }
  },
  {
    "qid": "536e46f27d100faa09000012",
    "question": "Which is the gene most commonly mutated in Tay-Sachs disease?",
    "answer-types": {
      "HEXA": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "553f7a71ab98a37113000009",
    "question": "In which types of DNA repair is the UvrAB complex involved?",
    "answer-types": {
      "suppression of illegitimate recombination": [],
      "TCR": [
        "umls:imft",
        "umls:rcpt",
        "umls:aapp"
      ],
      "nucleotide excision repair (NER)": [
        "umls:genf"
      ],
      "transcription-coupled repair (TCR)": [
        "umls:genf"
      ],
      "NER": [
        "umls:geoa"
      ],
      "nucleotide excision repair": [
        "umls:genf"
      ],
      "transcription-coupled repair": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 4,
      "umls:imft": 1,
      "umls:rcpt": 1,
      "umls:geoa": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "531e2695267d7dd05300000f",
    "question": "What is the localization of the protein encoded by the gene DNAJC11?",
    "answer-types": {
      "mitochondrial inner membrane": [
        "umls:celc"
      ]
    },
    "type-counts": {
      "umls:celc": 1
    }
  },
  {
    "qid": "515df199298dcd4e5100002a",
    "question": "What is the lay name of the treatment for CCSVI (chronic cerebro-spinal venous insufficiency) in multiple sclerosis.",
    "answer-types": {
      "LIberation therapy": []
    },
    "type-counts": {}
  },
  {
    "qid": "53148a07dae131f847000002",
    "question": "Which hormone abnormalities are characteristic to Pendred syndrome?",
    "answer-types": {
      "thyroid": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "52eea4dcc8da89891000000c",
    "question": "What is the mode of inheritance of long QT Jervell and Lange-Nielsen syndrome?",
    "answer-types": {
      "autosomal recessive": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "53355befd6d3ac6a34000046",
    "question": "List programs suitable for protein docking",
    "answer-types": {
      "DockRank": [],
      "CAVITY": [
        "umls:dsyn"
      ],
      "DISCORE": [],
      "LiGenDock": [],
      "DockoMatic": [],
      "DockTrina": [],
      "SOL": [
        "umls:sbst"
      ],
      "AutodockVina": [],
      "HotLig": [],
      "PHASE": [
        "umls:tmco"
      ],
      "DOCK": [
        "umls:plnt"
      ],
      "HADDOCK": [
        "umls:fish"
      ],
      "GalaxyDock": [],
      "ZDOCK": [],
      "CSBB-ConeExclusion": []
    },
    "type-counts": {
      "umls:fish": 1,
      "umls:plnt": 1,
      "umls:sbst": 1,
      "umls:dsyn": 1,
      "umls:tmco": 1
    }
  },
  {
    "qid": "52f89f4f2059c6d71c00004e",
    "question": "Which genes have been found mutated in Gray platelet syndrome patients?",
    "answer-types": {
      "GFI1B": [
        "umls:gngm"
      ],
      "NBEAL2": [
        "umls:gngm"
      ],
      "GATA1": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 3
    }
  },
  {
    "qid": "56c85ed65795f9a73e000012",
    "question": "Does dasatinib promote or inhibit T-cell proliferation?",
    "answer-types": {
      "inhibits": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "533c38b3c45e133714000009",
    "question": "What is an approximate number of CTCF binding sites in the human genome?",
    "answer-types": {
      "30,000-50,000": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "550712739d0faaa527000008",
    "question": "Which mutations in the cardiac isoform of the ryanodine receptor (RyR2) have been found to be related to CPVT?",
    "answer-types": {
      "RyR2-R4497C": [],
      "RyR2-R4497C (RyR2-R4496C in the mouse)": [],
      "RyR2-N4104K": [],
      "RyR2-V2475F": [],
      "RyR2-S4153R": [],
      "RyR2-R4959Q": [],
      "RyR2-L433P": [],
      "RyR2-P4902L": [],
      "RyR2-N2386I": [],
      "RyR2-S2246L": [],
      "RyR2-R4496C in the mouse": [],
      "RyR2-R2474S": [],
      "RyR2-G230C": [],
      "RyR2-E189D": [],
      "RyR2-V2306I,": []
    },
    "type-counts": {}
  },
  {
    "qid": "51542e6fd24251bc05000082",
    "question": "Which population has a high frequency of the HLA-B*1502 allele?",
    "answer-types": {
      "Han Chinese and other Asian populations, except Japanese": []
    },
    "type-counts": {}
  },
  {
    "qid": "53442023aeec6fbd07000007",
    "question": "Which is the substrate of the haspin kinase during mitosis?",
    "answer-types": {
      "Histone 3 at Thr3": []
    },
    "type-counts": {}
  },
  {
    "qid": "511a20f3df1ebcce7d00000c",
    "question": "Which are the most widely reported side-effects in the treatment of Crohn\u0027s disease?",
    "answer-types": {
      "paresthesia": [
        "umls:dsyn"
      ],
      "liver toxicity": [
        "umls:dsyn"
      ],
      "alopecia": [
        "umls:dsyn"
      ],
      "Leukopenia": [
        "umls:dsyn"
      ],
      "pericarditis": [
        "umls:dsyn"
      ],
      "psoriasis": [
        "umls:dsyn"
      ],
      "pancreatitis": [
        "umls:dsyn"
      ],
      "hemolysis": [
        "umls:patf"
      ]
    },
    "type-counts": {
      "umls:patf": 1,
      "umls:dsyn": 7
    }
  },
  {
    "qid": "534427f8aeec6fbd07000009",
    "question": "Are most driver gene mutations synonymous or non-synonymous?",
    "answer-types": {
      "non-synonymous": [
        "_CHOICE"
      ]
    },
    "type-counts": {
      "_CHOICE": 1
    }
  },
  {
    "qid": "533abc76d6d3ac6a34000064",
    "question": "Which cyclin- dependent kinase inhibitor is regulated by Bmi-1?",
    "answer-types": {
      "p16INK4": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1
    }
  },
  {
    "qid": "518cca6f310faafe0800000a",
    "question": "Which microRNAs are involved in exercise adaptation?",
    "answer-types": {
      "miR-20a": [
        "umls:gngm"
      ],
      "miR-133b": [
        "umls:gngm"
      ],
      "miR-146a": [
        "umls:gngm"
      ],
      "miR-1": [
        "umls:gngm"
      ],
      "miR-133a": [
        "umls:gngm"
      ],
      "miR-107": [
        "umls:gngm"
      ],
      "miR-206": [
        "umls:gngm"
      ],
      "miR-208a": [
        "umls:gngm"
      ],
      "miR-494": [
        "umls:gngm"
      ],
      "miR-23": [
        "umls:nnon",
        "umls:bacs"
      ],
      "miR-221": [
        "umls:gngm"
      ],
      "miR-133": [
        "umls:nnon"
      ],
      "miR-222": [
        "umls:gngm"
      ],
      "miR-21": [
        "umls:gngm"
      ],
      "miR-181": [
        "umls:nnon"
      ]
    },
    "type-counts": {
      "umls:nnon": 3,
      "umls:bacs": 1,
      "umls:gngm": 12
    }
  },
  {
    "qid": "5717cdd2070aa3d072000001",
    "question": "List inhibtors targeting the mitochondrial permeability transition pore.",
    "answer-types": {
      "Sanglifehrin A": [
        "umls:antb",
        "umls:orch"
      ],
      "NIM811": [
        "umls:aapp",
        "umls:phsu"
      ],
      "Cyclosporine A": [
        "umls:aapp",
        "umls:phsu"
      ],
      "TRO-19622": [],
      "N-metyl-4-isoleucine-cyclosporine": [],
      "Atractyloside": [
        "umls:hops",
        "umls:orch"
      ]
    },
    "type-counts": {
      "umls:hops": 1,
      "umls:antb": 1,
      "umls:orch": 2,
      "umls:phsu": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "571f5c150fd6f91b68000009",
    "question": "Which protein is found to be mutated in Friedreich\u0027s ataxia?",
    "answer-types": {
      "Frataxin": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "51387022bee46bd34c000002",
    "question": "Which is the process that Conserved noncoding elements mostly regulate?",
    "answer-types": {
      "Development": [
        "umls:phsf"
      ]
    },
    "type-counts": {
      "umls:phsf": 1
    }
  },
  {
    "qid": "56d1fd67f22319765a000002",
    "question": "List bacterial species identified in the iceman tissues.",
    "answer-types": {
      "Agromyces": [
        "umls:bact"
      ],
      "Bacteroides sp": [
        "umls:bact"
      ],
      "Clostridium sordellii": [
        "umls:bact"
      ],
      "Clostridium ghonii": [
        "umls:bact"
      ],
      "Eubacterium tenue": [
        "umls:bact"
      ],
      "Spirochete Treponema denticola": [],
      "Sphingomonas": [
        "umls:bact"
      ],
      "Microbacterium": [
        "umls:bact"
      ],
      "Afipia": [
        "umls:bact"
      ],
      "Clostridium perfringens": [
        "umls:bact"
      ],
      "Curtobacterium": [
        "umls:bact"
      ],
      "Vibrio": [
        "umls:bact"
      ]
    },
    "type-counts": {
      "umls:bact": 11
    }
  },
  {
    "qid": "56df03c751531f7e3300000a",
    "question": "Which properties of the mRNA does N6-methyladenosine (m6A) affect?",
    "answer-types": {
      "mRNA stability": [
        "umls:qlco"
      ]
    },
    "type-counts": {
      "umls:qlco": 1
    }
  },
  {
    "qid": "517775c78ed59a060a000033",
    "question": "List some ways to reverse Tau hyperphosphorylation in Tauopathies?",
    "answer-types": {
      "un-competitive inhibitor of N-methyl-D-aspartate receptors": [],
      "Administration glycogen synthase kinase-3": [],
      "Administration of 7-nitroindazole": [],
      "hUCB-MSC": [],
      "Administration glycogen synthase kinase-3  (GSK-3) inhibitors": [],
      "Human umbilical cord blood-derived mesenchymal stem cells": [],
      "Administration of 7-nitroindazole  (neuronal nitric oxide synthase inhibitor)": [],
      "GSK-3": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Administration of Memantine  (un-competitive inhibitor of N-methyl-D-aspartate receptors)": [],
      "Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) transplantation": [],
      "neuronal nitric oxide synthase inhibitor": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Administration of M1 muscarinic agonists such as AF150(S) and AF267B": [],
      "Administration of Memantine": []
    },
    "type-counts": {
      "umls:enzy": 2,
      "umls:aapp": 2
    }
  },
  {
    "qid": "533be71dfd9a95ea0d000009",
    "question": "Which is the histone residue methylated by MLL1?",
    "answer-types": {
      "H3K4": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:aapp": 1
    }
  },
  {
    "qid": "56c8274f5795f9a73e00000d",
    "question": "Which type of cells is affected in Amyotrophic Lateral Sclerosis?",
    "answer-types": {
      "Motor neurons": [
        "umls:cell"
      ]
    },
    "type-counts": {
      "umls:cell": 1
    }
  },
  {
    "qid": "54e0dfa91388e8454a000018",
    "question": "List components of the CRSP/Med complex.",
    "answer-types": {
      "Mediator of RNA polymerase II transcription subunit 23": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Mediator of RNA polymerase II transcription subunit 26": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Mediator of RNA polymerase II transcription subunit 27": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Mediator of RNA polymerase II transcription subunit 24": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Mediator of RNA polymerase II transcription subunit 14": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Mediator of RNA polymerase II transcription subunit 17": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Mediator of RNA polymerase II transcription subunit 7": [
        "umls:bacs",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:bacs": 7,
      "umls:aapp": 7
    }
  },
  {
    "qid": "5545e65bd355485447000001",
    "question": "Patients of which disease could be treated by utilizing knowledge obtained from experiments suppressing TDP-43 toxicity in yeast?",
    "answer-types": {
      "Amyotrophic lateral sclerosis (ALS)": [
        "umls:ftcn"
      ],
      "ALS": [
        "umls:dsyn"
      ],
      "Amyotrophic lateral sclerosis": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:ftcn": 1,
      "umls:dsyn": 2
    }
  },
  {
    "qid": "56f3faed09dd18d46b000002",
    "question": "What is the mechanism of viroid replication?",
    "answer-types": {
      "rolling cycle": []
    },
    "type-counts": {}
  },
  {
    "qid": "517539e68ed59a060a000028",
    "question": "Which mitochondrial genes are regulated by thyroid hormone?",
    "answer-types": {
      "NADH dehydrogenase subunit 3": [
        "umls:gngm"
      ],
      "subunit 6 of ATP synthase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "ATPase-6": [
        "umls:gngm"
      ],
      "ND3": [
        "umls:gngm"
      ],
      "mitochondrial II and III subunits of cytochrome-c oxidase": []
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:gngm": 3,
      "umls:aapp": 1
    }
  },
  {
    "qid": "531464a6e3eabad021000014",
    "question": "Mutation of which gene is associated with McLeod syndrome?",
    "answer-types": {
      "XK": [
        "umls:geoa"
      ]
    },
    "type-counts": {
      "umls:geoa": 1
    }
  },
  {
    "qid": "53124bdae3eabad02100000b",
    "question": "Which is the molecular target of the immunosuppressant drug Rapamycin?",
    "answer-types": {
      "mTOR": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "54fc91e96ad7dcbc12000001",
    "question": "PBT2 has been tested for which disorder?",
    "answer-types": {
      "Alzheimer\u0027s disease": [
        "umls:dsyn"
      ]
    },
    "type-counts": {
      "umls:dsyn": 1
    }
  },
  {
    "qid": "52e929eb98d0239505000023",
    "question": "List interaction partners for the protein GATA1.",
    "answer-types": {
      "Gfi-1b": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Ldb-1": [
        "umls:aapp"
      ],
      "ACF/WCRF complex": [],
      "LMO2-C": [],
      "TAL-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "FOG-1": [
        "umls:aapp"
      ],
      "MeCP1 complex": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:gngm": 1,
      "umls:bacs": 2,
      "umls:aapp": 4
    }
  },
  {
    "qid": "53318685d6d3ac6a3400003d",
    "question": "What is the mode of inheritance of Acromicric dysplasia?",
    "answer-types": {
      "autosomal dominant": [
        "umls:genf"
      ]
    },
    "type-counts": {
      "umls:genf": 1
    }
  },
  {
    "qid": "518cb5ab310faafe08000008",
    "question": "Which are the best treatment options to treat Helicobacter pylori?",
    "answer-types": {
      "amoxicillin": [
        "umls:antb",
        "umls:orch"
      ],
      "rifabutin": [
        "umls:antb",
        "umls:orch"
      ],
      "claritromycin": [],
      "Proton pump inhibithors": [],
      "metronidazole": [
        "umls:orch",
        "umls:phsu"
      ],
      "Eudragit L100": [
        "umls:bodm",
        "umls:orch"
      ]
    },
    "type-counts": {
      "umls:antb": 2,
      "umls:bodm": 1,
      "umls:orch": 4,
      "umls:phsu": 1
    }
  },
  {
    "qid": "570a6d03cf1c325851000025",
    "question": "List sclerostin interaction partners.",
    "answer-types": {
      "gremlin-1": [
        "umls:bacs",
        "umls:aapp"
      ],
      "annexin A1": [
        "umls:bacs",
        "umls:aapp",
        "umls:phsu"
      ],
      "noggin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "fetuin A": [
        "umls:bacs",
        "umls:aapp"
      ],
      "LRP5": [
        "umls:rcpt",
        "umls:aapp"
      ],
      "follistatin": [
        "umls:bacs",
        "umls:aapp"
      ],
      "casein kinase II": [
        "umls:enzy",
        "umls:aapp"
      ],
      "annexin A2": [
        "umls:bacs",
        "umls:aapp"
      ],
      "collagen α1": [],
      "Phex": [
        "umls:gngm"
      ],
      "carbonic anhydrase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "alkaline phosphatase": [
        "umls:enzy",
        "umls:aapp"
      ],
      "midkine": [
        "umls:bacs",
        "umls:aapp"
      ],
      "secreted frizzled related protein 4": [
        "umls:gngm"
      ],
      "asporin": [
        "umls:gngm"
      ],
      "erbB-3": [
        "umls:rcpt",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 3,
      "umls:rcpt": 2,
      "umls:gngm": 3,
      "umls:bacs": 7,
      "umls:phsu": 1,
      "umls:aapp": 12
    }
  },
  {
    "qid": "5326300fd6d3ac6a34000005",
    "question": "What imaging modalities have been listed as method of choice to diagnose CSF leak?",
    "answer-types": {
      "CT cisternography": [
        "umls:diap"
      ],
      "three-dimensional constructive interference in steady state": [],
      "3D-CISS": [],
      "CTC": [
        "umls:cell"
      ]
    },
    "type-counts": {
      "umls:cell": 1,
      "umls:diap": 1
    }
  },
  {
    "qid": "511a3573df1ebcce7d000018",
    "question": "How many tissue kallikrein genes are present in the human genome?",
    "answer-types": {
      "15": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 1
    }
  },
  {
    "qid": "51be411b047fa84d1d000006",
    "question": "Which are currently available software tools for detecting rare codon clusters in coding sequences?",
    "answer-types": {
      "PAUSE": [
        "umls:dora"
      ],
      "%MinMax": [],
      "RiboTempo": [],
      "Sliding Window": [],
      "Sherlocc": [],
      "LaTcOm": []
    },
    "type-counts": {
      "umls:dora": 1
    }
  },
  {
    "qid": "56c5c7915795f9a73e000004",
    "question": "Where does CTCF colocalize with cohesin?",
    "answer-types": {
      "In imprinted and repressed, highly compacted loci that are prone to recombination events.": []
    },
    "type-counts": {}
  },
  {
    "qid": "54db7217c4c6ce8e1d000003",
    "question": "How many and which are the different isoforms for the ryanodine receptor?",
    "answer-types": {
      "RyR2": [
        "_QUANTITY"
      ],
      "RyR1": [
        "_QUANTITY"
      ],
      "Ryanodine Receptor type 3": [
        "_QUANTITY"
      ],
      "Ryanodine Receptor type 2": [
        "_QUANTITY"
      ],
      "Ryanodine Receptor type 1": [
        "_QUANTITY"
      ],
      "RyR3": [
        "_QUANTITY"
      ]
    },
    "type-counts": {
      "_QUANTITY": 6
    }
  },
  {
    "qid": "56be143eef6e394741000009",
    "question": "Name triad of Wernicke encephalopathy.",
    "answer-types": {
      "ataxia": [
        "umls:sosy"
      ],
      "ophthalmoplegia": [
        "umls:sosy"
      ],
      "confusion": [
        "umls:mobd"
      ]
    },
    "type-counts": {
      "umls:sosy": 2,
      "umls:mobd": 1
    }
  },
  {
    "qid": "56c865d25795f9a73e000016",
    "question": "Which compound is a specific inhibitor for Nox1 and Nox4?",
    "answer-types": {
      "GKT136901": [
        "umls:orch",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:orch": 1,
      "umls:phsu": 1
    }
  },
  {
    "qid": "550e828c71445a662f000002",
    "question": "Which molecule is targeted by the drug Gevokizumab?",
    "answer-types": {
      "IL-1β": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "5506a7a48e1671127b000008",
    "question": "Which protein phosphatases have been found to dephosphorylate phospholamban?",
    "answer-types": {
      "PP1": [
        "umls:imft",
        "umls:aapp"
      ],
      "PP2C": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Protein Phosphatase 2B": [
        "umls:enzy",
        "umls:aapp"
      ],
      "PP2B": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Protein Phosphatase 2C": [
        "umls:enzy",
        "umls:aapp"
      ],
      "PP2A": [
        "umls:bacs",
        "umls:aapp"
      ],
      "Protein Phosphatase 1": [
        "umls:enzy",
        "umls:aapp"
      ],
      "Protein phosphatase 2A": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 6,
      "umls:imft": 1,
      "umls:bacs": 1,
      "umls:aapp": 8
    }
  },
  {
    "qid": "5133b9455274a5fb0700000c",
    "question": "What is the most prominent sequence consensus for the polyadenylation site?",
    "answer-types": {
      "AAUAAA": [
        "umls:nnon",
        "umls:bacs"
      ],
      "AATAAA": [
        "umls:gngm"
      ]
    },
    "type-counts": {
      "umls:nnon": 1,
      "umls:gngm": 1,
      "umls:bacs": 1
    }
  },
  {
    "qid": "54f608f85f206a0c06000007",
    "question": "What is the Drosophila melanogaster Groucho protein?",
    "answer-types": {
      "Groucho (Gro) is a Drosophila melanogaster transcriptional corepressor": [
        "umls:aapp"
      ],
      "Gro": [
        "umls:imft",
        "umls:aapp"
      ],
      "Groucho": [
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:imft": 1,
      "umls:aapp": 3
    }
  },
  {
    "qid": "56c048acef6e39474100001c",
    "question": "Which enzyme is inhibited by Imetelstat?",
    "answer-types": {
      "telomerase": [
        "umls:enzy",
        "umls:aapp"
      ]
    },
    "type-counts": {
      "umls:enzy": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "532c12f2d6d3ac6a3400001d",
    "question": "Which are the cardiac effects of thyronamines?",
    "answer-types": {
      "negative chronotropy": [
        "umls:ortf"
      ],
      "negative inotropism": []
    },
    "type-counts": {
      "umls:ortf": 1
    }
  },
  {
    "qid": "512d0e635274a5fb07000005",
    "question": "Which is the most widely used anti-TNF drug?",
    "answer-types": {
      "Etanercept": [
        "umls:aapp",
        "umls:phsu"
      ]
    },
    "type-counts": {
      "umls:phsu": 1,
      "umls:aapp": 1
    }
  },
  {
    "qid": "532c0ac4d6d3ac6a3400001a",
    "question": "What are the main benefits of pharmacophore models?",
    "answer-types": {
      "Due their simplicity they are proper for large scale virtual screening": [],
      "They represent chemical functions valid not only for the existing bounds but also for unknown molecules.": [],
      "They are comprehensive and editable, so by changing chemical feature contains information can be easily trace back.": []
    },
    "type-counts": {}
  },
  {
    "qid": "56ffd805cf1c32585100000a",
    "question": "Which is the main difference between Alu and B1 repeats?",
    "answer-types": {
      "it is the mouse homolog to the left Alu monomer": []
    },
    "type-counts": {}
  },
  {
    "qid": "533ba85ffd9a95ea0d000008",
    "question": "What is the frequency of mutations induced spontaneously through Ethylnitrosourea (ENU) mutagenesis?",
    "answer-types": {
      "1/100000": [
        "umls:clnd"
      ]
    },
    "type-counts": {
      "umls:clnd": 1
    }
  },
  {
    "qid": "52e7b7cb98d023950500001c",
    "question": "Which drugs affect insulin resistance in obesity?",
    "answer-types": {
      "ACE inhibitors": [
        "umls:phsu"
      ],
      "Enistein": []
    },
    "type-counts": {
      "umls:phsu": 1
    }
  }
]