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<!DOCTYPE html>
<html>
<head><meta charset="utf-8" />
<title>benchmark_summary</title>
<script src="https://cdnjs.cloudflare.com/ajax/libs/require.js/2.1.10/require.min.js"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/2.0.3/jquery.min.js"></script>
<style type="text/css">
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<h1 id="Table-of-Contents">Table of Contents<a class="anchor-link" href="#Table-of-Contents">¶</a></h1><ul>
<li><a href="#Benchmarks">Benchmarks</a><ul>
<li><a href="#1.-EggNOG-mapper-vs-BLAST">1. EggNOG-mapper vs BLAST</a></li>
<li><a href="#2.-EggNOG-mapper-vs-InterProScan">2. EggNOG-mapper vs InterProScan</a></li>
<li><a href="#3.-EggNOG-mapper-vs-CAFA2">3. EggNOG-mapper vs CAFA2</a><ul>
<li><a href="#CAFA2-Evaluation-code">CAFA2 Evaluation code</a><ul>
<li><a href="#Results">Results</a></li>
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<li><a href="#CAFA2-Reference-data">CAFA2 Reference data</a></li>
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<li><a href="#4.-EggNOG-mapper-vs-non-model-organisms">4. EggNOG-mapper vs non-model organisms</a></li>
<li><a href="#5.-EggNOG-mapper-vs-InterProScan-with-metagenomics-data">5. EggNOG-mapper vs InterProScan with metagenomics data</a><ul>
<li><a href="#Sample-0-GOs-from-reads:-2821---GOs-from-emapper:-3177---GOs-from-ipro:-1375">Sample-0 GOs from reads: 2821 GOs from emapper: 3177 GOs from ipro: 1375</a></li>
<li><a href="#Sample-1-GOs-from-reads:-2857---GOs-from-emapper:-3483---GOs-from-ipro:-1415">Sample-1 GOs from reads: 2857 GOs from emapper: 3483 GOs from ipro: 1415</a></li>
<li><a href="#Sample-2-GOs-from-reads:-2784---GOs-from-emapper:-3024---GOs-from-ipro:-1188">Sample-2 GOs from reads: 2784 GOs from emapper: 3024 GOs from ipro: 1188</a></li>
<li><a href="#Sample-3-GOs-from-reads:-2753---GOs-from-emapper:-3213---GOs-from-ipro:-1335">Sample-3 GOs from reads: 2753 GOs from emapper: 3213 GOs from ipro: 1335</a></li>
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<div class=" highlight hl-ipython2"><pre><span class="o">%</span><span class="k">matplotlib</span> auto
<span class="kn">import</span> <span class="nn">cPickle</span>
<span class="kn">import</span> <span class="nn">plot_functions</span>
<span class="nb">reload</span><span class="p">(</span><span class="n">plot_functions</span><span class="p">)</span>
<span class="n">bench</span> <span class="o">=</span> <span class="n">cPickle</span><span class="o">.</span><span class="n">load</span><span class="p">(</span><span class="nb">open</span><span class="p">(</span><span class="s">'all_benchmark_tables.pkl'</span><span class="p">))</span>
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<pre>/Users/jhc/anaconda/lib/python2.7/site-packages/pandas/computation/__init__.py:19: UserWarning: The installed version of numexpr 2.4.4 is not supported in pandas and will be not be used
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<h1 id="Benchmarks">Benchmarks<a class="anchor-link" href="#Benchmarks">¶</a></h1>
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<h2 id="1.-EggNOG-mapper-vs-BLAST">1. EggNOG-mapper vs BLAST<a class="anchor-link" href="#1.-EggNOG-mapper-vs-BLAST">¶</a></h2>
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<div class=" highlight hl-ipython2"><pre><span class="n">plot_functions</span><span class="o">.</span><span class="n">get_emapper_blast_summary</span><span class="p">(</span><span class="n">bench</span><span class="p">,</span> <span class="n">refresh_plots</span><span class="o">=</span><span class="bp">True</span><span class="p">)</span>
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<h2 id="2.-EggNOG-mapper-vs-InterProScan">2. EggNOG-mapper vs InterProScan<a class="anchor-link" href="#2.-EggNOG-mapper-vs-InterProScan">¶</a></h2>
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<div class=" highlight hl-ipython2"><pre><span class="n">plot_functions</span><span class="o">.</span><span class="n">get_emapper_interpro_summary</span><span class="p">(</span><span class="n">bench</span><span class="p">,</span> <span class="n">refresh_plots</span><span class="o">=</span><span class="bp">True</span><span class="p">)</span>
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<h2 id="3.-EggNOG-mapper-vs-CAFA2">3. EggNOG-mapper vs CAFA2<a class="anchor-link" href="#3.-EggNOG-mapper-vs-CAFA2">¶</a></h2>
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<p>CAFA2 benchmark was performed using the <a href="https://github.com/jhcepas/eggnog-mapper/tree/cafa2">cafa2 emapper branch</a>, where only the CAFA2 trained set was used for annotation.</p>
<p>EggNOG-mapper was run in diamond mode with default options (<code>--tax_scope auto --orthologs all</code>)</p>
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<div class=" highlight hl-ipython2"><pre><span class="o">%</span><span class="k">matplotlib</span> inline
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<h3 id="CAFA2-Evaluation-code">CAFA2 Evaluation code<a class="anchor-link" href="#CAFA2-Evaluation-code">¶</a></h3>
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<p>Code based on the official Matlab CAFA2 <a href="https://github.com/yuxjiang/CAFA2#how-to-evaluate-your-own-predictions-on-cafa2-benchmarks">benchmarking scripts</a></p>
<pre><code>for j = {'MFO', 'BPO', 'CCO'}
ont = j{1};
target_ont_file = sprintf('../ontology/%s.mat',upper(ont)) ;
target_truth_file = sprintf('../benchmark/groundtruth/%sa.mat', lower(ont));
target_list_file = sprintf('../benchmark/lists/%s_all_NK.txt', lower(ont));
load(target_ont_file);
load(target_truth_file);
target_ont = eval(ont);
benchmark = pfp_loaditem(target_list_file, 'char');
pred = cafa_import('../../emapper/all_seqs_filtered.dmnd-all.emapper.annotations.cafa2', target_ont, false);
cm_seq = pfp_seqcm(benchmark, pred, oa, 'toi', 'noroot')
pr = pfp_convcmstruct(cm_seq, 'pr', 'beta', 1.0);
prcurve = cafa_eval_seq_curve('1', benchmark, pr, 'partial');
fmax = pfp_seqmetric(benchmark, pred, oa, 'fmax', 'evmode', 'partial');
fprintf('(fmax/partial mode) all %s NK emapper (diamond-all): %f %f\n', ont, fmax, prcurve.coverage);
end</code></pre>
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