diff --git a/changelog.d/17250.misc b/changelog.d/17250.misc
new file mode 100644
index 00000000000..49834e83bae
--- /dev/null
+++ b/changelog.d/17250.misc
@@ -0,0 +1 @@
+Stop logging errors when receiving invalid User IDs in key querys requests.
diff --git a/synapse/handlers/e2e_keys.py b/synapse/handlers/e2e_keys.py
index 4f40e9ffd6e..560530a7b3f 100644
--- a/synapse/handlers/e2e_keys.py
+++ b/synapse/handlers/e2e_keys.py
@@ -149,6 +149,11 @@ async def query_devices(
             remote_queries = {}
 
             for user_id, device_ids in device_keys_query.items():
+                if not UserID.is_valid(user_id):
+                    # Ignore invalid user IDs, which is the same behaviour as if
+                    # the user existed but had no keys.
+                    continue
+
                 # we use UserID.from_string to catch invalid user ids
                 if self.is_mine(UserID.from_string(user_id)):
                     local_query[user_id] = device_ids