Dolan2015

Name

Dolan2015

Reference

Dolan DW, Zupanic A, Nelson G, Hall P, Miwa S, Kirkwood TB, Shanley DP (2015) Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21-Mediated Early Senescence Signalling. PLoS Comput Biol. 11:e1004246. doi: 10.1371/journal.pcbi.1004246.

Description

An integrated stochastic model of DNA damage repair by non-homologous end joining and of gamma irradiation-induced cellular senescence in human cells that are not apoptosis-prone, which successfully explains the changes that occur in the dynamics of DNA damage repair after irradiation.

Files

*Dolan2015.bngl - Base model set up to run using NFsim.

Curator

James Faeder

Notes