diff --git a/cmake/FindSpatiaLite.cmake b/cmake/FindSpatiaLite.cmake
index 86d03e190a46..acb3b0ed4ecc 100644
--- a/cmake/FindSpatiaLite.cmake
+++ b/cmake/FindSpatiaLite.cmake
@@ -11,69 +11,80 @@
 #    SPATIALITE_INCLUDE_DIR
 #    SPATIALITE_LIBRARY
 
-# This macro checks if the symbol exists
-include(CheckLibraryExists)
+find_package(PkgConfig REQUIRED)
+pkg_search_module(PC_SPATIALITE IMPORTED_TARGET spatialite)
 
-
-# FIND_PATH and FIND_LIBRARY normally search standard locations
-# before the specified paths. To search non-standard paths first,
-# FIND_* is invoked first with specified paths and NO_DEFAULT_PATH
-# and then again with no specified paths to search the default
-# locations. When an earlier FIND_* succeeds, subsequent FIND_*s
-# searching for the same item do nothing.
-
-# try to use sqlite framework on mac
-# want clean framework path, not unix compatibility path
-IF (APPLE AND NOT IOS)
-  IF (CMAKE_FIND_FRAMEWORK MATCHES "FIRST"
-      OR CMAKE_FRAMEWORK_PATH MATCHES "ONLY"
-      OR NOT CMAKE_FIND_FRAMEWORK)
-    SET (CMAKE_FIND_FRAMEWORK_save ${CMAKE_FIND_FRAMEWORK} CACHE STRING "" FORCE)
-    SET (CMAKE_FIND_FRAMEWORK "ONLY" CACHE STRING "" FORCE)
-    FIND_PATH(SPATIALITE_INCLUDE_DIR SQLite3/spatialite.h)
-    # if no SpatiaLite header, we don't want SQLite find below to succeed
-    IF (SPATIALITE_INCLUDE_DIR)
-      FIND_LIBRARY(SPATIALITE_LIBRARY SQLite3)
-      # FIND_PATH doesn't add "Headers" for a framework
-      SET (SPATIALITE_INCLUDE_DIR ${SPATIALITE_LIBRARY}/Headers CACHE PATH "Path to a file." FORCE)
-    ENDIF (SPATIALITE_INCLUDE_DIR)
-    SET (CMAKE_FIND_FRAMEWORK ${CMAKE_FIND_FRAMEWORK_save} CACHE STRING "" FORCE)
-  ENDIF ()
-ENDIF (APPLE AND NOT IOS)
-
-FIND_PATH(SPATIALITE_INCLUDE_DIR spatialite.h
-  /usr/include
-  "$ENV{INCLUDE}"
-  "$ENV{LIB_DIR}/include"
-  "$ENV{LIB_DIR}/include/spatialite"
-  )
-
-FIND_LIBRARY(SPATIALITE_LIBRARY NAMES spatialite_i spatialite PATHS
-  /usr/lib
-  $ENV{LIB}
-  $ENV{LIB_DIR}/lib
-  )
-
-IF (SPATIALITE_INCLUDE_DIR AND SPATIALITE_LIBRARY)
-   SET(SPATIALITE_FOUND TRUE)
-ENDIF (SPATIALITE_INCLUDE_DIR AND SPATIALITE_LIBRARY)
-
-
-IF (SPATIALITE_FOUND)
-
-   IF (NOT SPATIALITE_FIND_QUIETLY)
-      MESSAGE(STATUS "Found SpatiaLite: ${SPATIALITE_LIBRARY}")
-   ENDIF (NOT SPATIALITE_FIND_QUIETLY)
-
-   IF(APPLE)
-     # no extra LDFLAGS used in link test, may fail in OS X SDK
-     SET(CMAKE_REQUIRED_LIBRARIES "-F/Library/Frameworks" ${CMAKE_REQUIRED_LIBRARIES})
-   ENDIF(APPLE)
-
-ELSE (SPATIALITE_FOUND)
-
-   IF (SPATIALITE_FIND_REQUIRED)
-     MESSAGE(FATAL_ERROR "Could not find SpatiaLite. Include: ${SPATIALITE_INCLUDE_DIR} Library: ${SPATIALITE_LIBRARY}")
-   ENDIF (SPATIALITE_FIND_REQUIRED)
-
-ENDIF (SPATIALITE_FOUND)
+if(PC_SPATIALITE_FOUND)
+  add_library(spatialite::spatialite ALIAS PkgConfig::PC_SPATIALITE)
+else()
+  # This macro checks if the symbol exists
+  include(CheckLibraryExists)
+  
+  
+  # FIND_PATH and FIND_LIBRARY normally search standard locations
+  # before the specified paths. To search non-standard paths first,
+  # FIND_* is invoked first with specified paths and NO_DEFAULT_PATH
+  # and then again with no specified paths to search the default
+  # locations. When an earlier FIND_* succeeds, subsequent FIND_*s
+  # searching for the same item do nothing.
+  
+  # try to use sqlite framework on mac
+  # want clean framework path, not unix compatibility path
+  IF (APPLE AND NOT IOS)
+    IF (CMAKE_FIND_FRAMEWORK MATCHES "FIRST"
+        OR CMAKE_FRAMEWORK_PATH MATCHES "ONLY"
+        OR NOT CMAKE_FIND_FRAMEWORK)
+      SET (CMAKE_FIND_FRAMEWORK_save ${CMAKE_FIND_FRAMEWORK} CACHE STRING "" FORCE)
+      SET (CMAKE_FIND_FRAMEWORK "ONLY" CACHE STRING "" FORCE)
+      FIND_PATH(SPATIALITE_INCLUDE_DIR SQLite3/spatialite.h)
+      # if no SpatiaLite header, we don't want SQLite find below to succeed
+      IF (SPATIALITE_INCLUDE_DIR)
+        FIND_LIBRARY(SPATIALITE_LIBRARY SQLite3)
+        # FIND_PATH doesn't add "Headers" for a framework
+        SET (SPATIALITE_INCLUDE_DIR ${SPATIALITE_LIBRARY}/Headers CACHE PATH "Path to a file." FORCE)
+      ENDIF (SPATIALITE_INCLUDE_DIR)
+      SET (CMAKE_FIND_FRAMEWORK ${CMAKE_FIND_FRAMEWORK_save} CACHE STRING "" FORCE)
+    ENDIF ()
+  ENDIF (APPLE AND NOT IOS)
+  
+  FIND_PATH(SPATIALITE_INCLUDE_DIR spatialite.h
+    /usr/include
+    "$ENV{INCLUDE}"
+    "$ENV{LIB_DIR}/include"
+    "$ENV{LIB_DIR}/include/spatialite"
+    )
+  
+  FIND_LIBRARY(SPATIALITE_LIBRARY NAMES spatialite_i spatialite PATHS
+    /usr/lib
+    $ENV{LIB}
+    $ENV{LIB_DIR}/lib
+    )
+  
+  IF (SPATIALITE_INCLUDE_DIR AND SPATIALITE_LIBRARY)
+     SET(SPATIALITE_FOUND TRUE)
+  ENDIF (SPATIALITE_INCLUDE_DIR AND SPATIALITE_LIBRARY)
+  
+  
+  IF (SPATIALITE_FOUND)
+     add_library(spatialite::spatialite UNKNOWN IMPORTED)
+     target_link_libraries(spatialite::spatialite INTERFACE ${SPATIALITE_LIBRARY})
+     target_include_directories(spatialite::spatialite INTERFACE ${SPATIALITE_INCLUDE_DIR})
+     set_target_properties(spatialite::spatialite PROPERTIES IMPORTED_LOCATION ${SPATIALITE_LIBRARY})
+  
+     IF (NOT SPATIALITE_FIND_QUIETLY)
+        MESSAGE(STATUS "Found SpatiaLite: ${SPATIALITE_LIBRARY}")
+     ENDIF (NOT SPATIALITE_FIND_QUIETLY)
+  
+     IF(APPLE)
+       # no extra LDFLAGS used in link test, may fail in OS X SDK
+       SET(CMAKE_REQUIRED_LIBRARIES "-F/Library/Frameworks" ${CMAKE_REQUIRED_LIBRARIES})
+     ENDIF(APPLE)
+  
+  ELSE (SPATIALITE_FOUND)
+  
+     IF (SPATIALITE_FIND_REQUIRED)
+       MESSAGE(FATAL_ERROR "Could not find SpatiaLite. Include: ${SPATIALITE_INCLUDE_DIR} Library: ${SPATIALITE_LIBRARY}")
+     ENDIF (SPATIALITE_FIND_REQUIRED)
+  
+  ENDIF (SPATIALITE_FOUND)
+endif()
diff --git a/external/qspatialite/CMakeLists.txt b/external/qspatialite/CMakeLists.txt
index 0e5df6a8a1f1..33536dafe913 100644
--- a/external/qspatialite/CMakeLists.txt
+++ b/external/qspatialite/CMakeLists.txt
@@ -17,8 +17,7 @@ add_library(qsqlspatialite SHARED ${QSQLSPATIALITE_SRC})
 target_link_libraries(qsqlspatialite
         ${Qt5Core_LIBRARIES}
         ${Qt5Sql_LIBRARIES}
-	${SQLITE3_LIBRARY}
-	${SPATIALITE_LIBRARY}
+        spatialite::spatialite
 	qgis_core
 )
 
diff --git a/src/analysis/CMakeLists.txt b/src/analysis/CMakeLists.txt
index 28b686769ad9..cf0d76e3969c 100644
--- a/src/analysis/CMakeLists.txt
+++ b/src/analysis/CMakeLists.txt
@@ -458,7 +458,6 @@ if (WITH_PDAL AND PDAL_2_5_OR_HIGHER)
   )
 endif()
 
-include_directories(SYSTEM ${SPATIALITE_INCLUDE_DIR})
 include_directories(SYSTEM ${SPATIALINDEX_INCLUDE_DIR})
 include_directories(SYSTEM ${SQLITE3_INCLUDE_DIR})
 include_directories(BEFORE raster)
diff --git a/src/core/CMakeLists.txt b/src/core/CMakeLists.txt
index db1c050f154b..79fb3e24394e 100644
--- a/src/core/CMakeLists.txt
+++ b/src/core/CMakeLists.txt
@@ -2262,12 +2262,6 @@ target_include_directories(qgis_core SYSTEM PUBLIC
   ${EXIV2_INCLUDE_DIR}
 )
 
-if (WITH_SPATIALITE)
-  target_include_directories(qgis_core SYSTEM PUBLIC
-    ${SPATIALITE_INCLUDE_DIR}
-  )
-endif()
-
 target_include_directories(qgis_core PUBLIC
   ${CMAKE_CURRENT_SOURCE_DIR}
   ${CMAKE_CURRENT_BINARY_DIR}
@@ -2444,7 +2438,7 @@ if (NOT IOS)
 endif()
 
 if (WITH_SPATIALITE)
-  target_link_libraries(qgis_core ${SPATIALITE_LIBRARY})
+  target_link_libraries(qgis_core spatialite::spatialite)
 endif()
 
 if (BUILD_WITH_QT6)
diff --git a/src/plugins/offline_editing/CMakeLists.txt b/src/plugins/offline_editing/CMakeLists.txt
index bb1c90af5459..c7ca21558d36 100644
--- a/src/plugins/offline_editing/CMakeLists.txt
+++ b/src/plugins/offline_editing/CMakeLists.txt
@@ -36,12 +36,6 @@ target_compile_features(plugin_offlineediting PRIVATE cxx_std_17)
 target_link_libraries(plugin_offlineediting
   qgis_core
   qgis_gui
-  ${SPATIALITE_LIBRARY}
-)
-
-include_directories(SYSTEM
-  ${SPATIALITE_INCLUDE_DIR}
-  ${SQLITE3_INCLUDE_DIR}
 )
 
 include_directories(
diff --git a/src/providers/spatialite/CMakeLists.txt b/src/providers/spatialite/CMakeLists.txt
index a9de25a4059b..efaad9a47c81 100644
--- a/src/providers/spatialite/CMakeLists.txt
+++ b/src/providers/spatialite/CMakeLists.txt
@@ -38,7 +38,7 @@ target_include_directories(provider_spatialite_a PUBLIC
 
 target_link_libraries(provider_spatialite_a
   qgis_core
-  ${SPATIALITE_LIBRARY}
+  spatialite::spatialite
 )
 
 # require c++17
@@ -95,7 +95,7 @@ else()
   
   target_link_libraries(provider_spatialite
     qgis_core
-    ${SPATIALITE_LIBRARY}
+    spatialite::spatialite
   )
 
   if (WITH_GUI)
diff --git a/src/providers/virtual/CMakeLists.txt b/src/providers/virtual/CMakeLists.txt
index 281e1156c03b..524740624c32 100644
--- a/src/providers/virtual/CMakeLists.txt
+++ b/src/providers/virtual/CMakeLists.txt
@@ -40,8 +40,6 @@ target_include_directories(provider_virtuallayer_a PUBLIC
 
 target_link_libraries(provider_virtuallayer_a
   qgis_core
-  ${SQLITE3_LIBRARY}
-  ${SPATIALITE_LIBRARY}
 )
 
 # require c++17
@@ -97,8 +95,6 @@ else()
     qgis_core
     ${QT_VERSION_BASE}::Core
     ${QT_VERSION_BASE}::Widgets
-    ${SQLITE3_LIBRARY}
-    ${SPATIALITE_LIBRARY}
   )
 
   if (WITH_GUI)
diff --git a/src/quickgui/CMakeLists.txt b/src/quickgui/CMakeLists.txt
index 95b853860bef..e1f1e0a85266 100644
--- a/src/quickgui/CMakeLists.txt
+++ b/src/quickgui/CMakeLists.txt
@@ -32,8 +32,6 @@ include_directories(SYSTEM
   ${SPATIALINDEX_INCLUDE_DIR}
   ${GEOS_INCLUDE_DIR}
   ${EXPAT_INCLUDE_DIR}
-  ${SQLITE3_INCLUDE_DIR}
-  ${SPATIALITE_INCLUDE_DIR}
   ${QCA_INCLUDE_DIR}
   ${QTKEYCHAIN_INCLUDE_DIR}
 )
diff --git a/src/quickgui/plugin/CMakeLists.txt b/src/quickgui/plugin/CMakeLists.txt
index fa42bede1d40..585e5edf71dc 100644
--- a/src/quickgui/plugin/CMakeLists.txt
+++ b/src/quickgui/plugin/CMakeLists.txt
@@ -35,7 +35,6 @@ include_directories(SYSTEM
   ${GEOS_INCLUDE_DIR}
   ${EXPAT_INCLUDE_DIR}
   ${SQLITE3_INCLUDE_DIR}
-  ${SPATIALITE_INCLUDE_DIR}
   ${QCA_INCLUDE_DIR}
   ${QTKEYCHAIN_INCLUDE_DIR}
 )
diff --git a/tests/src/quickgui/CMakeLists.txt b/tests/src/quickgui/CMakeLists.txt
index 2e27caff95d8..ea16e3f8a109 100644
--- a/tests/src/quickgui/CMakeLists.txt
+++ b/tests/src/quickgui/CMakeLists.txt
@@ -22,8 +22,6 @@ include_directories(SYSTEM
     ${SPATIALINDEX_INCLUDE_DIR}
     ${GDAL_INCLUDE_DIR}
     ${EXPAT_INCLUDE_DIR}
-    ${SQLITE3_INCLUDE_DIR}
-    ${SPATIALITE_INCLUDE_DIR}
     ${QCA_INCLUDE_DIR}
     ${QTKEYCHAIN_INCLUDE_DIR}
 )
diff --git a/tests/src/quickgui/app/CMakeLists.txt b/tests/src/quickgui/app/CMakeLists.txt
index ca552545042d..dd2c90a8258f 100644
--- a/tests/src/quickgui/app/CMakeLists.txt
+++ b/tests/src/quickgui/app/CMakeLists.txt
@@ -27,8 +27,6 @@ include_directories(SYSTEM
   ${SPATIALINDEX_INCLUDE_DIR}
   ${GEOS_INCLUDE_DIR}
   ${EXPAT_INCLUDE_DIR}
-  ${SQLITE3_INCLUDE_DIR}
-  ${SPATIALITE_INCLUDE_DIR}
   ${QCA_INCLUDE_DIR}
   ${QTKEYCHAIN_INCLUDE_DIR}
 )