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Merge pull request #2314 from geneontology/pgaudet-patch-110
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Update gorefs.yaml
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pgaudet authored May 2, 2024
2 parents d22d384 + 759ba18 commit 1e11b60
Showing 1 changed file with 8 additions and 13 deletions.
21 changes: 8 additions & 13 deletions metadata/gorefs.yaml
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- id: GO_REF:0000003
title: Gene Ontology annotation based on Enzyme Commission mapping
description: |-
Transitive assignment using Enzyme Commission identifiers. This method is used
for any database entry, such as a protein record in UniProtKB or TrEMBL, that
has had an Enzyme Commission number assigned. The corresponding GO term is determined
using the EC cross-references in the GO molecular function ontology. Also see
Hill et al., Genomics (2001) 74:121-128. The mapping file is available at
http://www.geneontology.org/external2go/ec2go.
In UniProt, proteins with enzymatic activities have traditionally been annotated using reference vocabularies such as the hierarchical enzyme classification of the Enzyme Nomenclature Committee of the IUBMB
(often referred to as Enzyme Commission or EC numbers; https://enzyme.expasy.org/). EC numbers are manually curated in Swiss-Prot ('UniProt Reviewed') entries and added automatically to
TrEMBL ('UniProt Uneviewed') entries. A mapping between EC numbers and GO Molecular Function terms is maintainted by GO editors. UniProt entries assigned with an EC number
with a GO mapping are automatically annotated with the correponding GO term, as described in PMID:30395331. GO annotations using this method receive the evidence code
Inferred from Electronic Annotation (IEA). This method has been evaluated at up to 100% accurate (Camon et. al. 2005). The EC2GO mapping file is available at
http://current.geneontology.org/ontology/external2go/ec2go.
alt_id:
- GO_REF:0000005
authors: GOA curators, MGI curators
citation: PMID:11374909
external_accession:
- MGI:2152096
- J:72245
- ZFIN:ZDB-PUB-031118-3
- SGD_REF:S000124037
authors: GO Central curators
citation: PMID:31688925
is_obsolete: false
year: 2001
- id: GO_REF:0000004
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