diff --git a/metadata/gorefs.yaml b/metadata/gorefs.yaml index 3bd6ca05..f381101d 100644 --- a/metadata/gorefs.yaml +++ b/metadata/gorefs.yaml @@ -35,21 +35,16 @@ - id: GO_REF:0000003 title: Gene Ontology annotation based on Enzyme Commission mapping description: |- - Transitive assignment using Enzyme Commission identifiers. This method is used - for any database entry, such as a protein record in UniProtKB or TrEMBL, that - has had an Enzyme Commission number assigned. The corresponding GO term is determined - using the EC cross-references in the GO molecular function ontology. Also see - Hill et al., Genomics (2001) 74:121-128. The mapping file is available at - http://www.geneontology.org/external2go/ec2go. + In UniProt, proteins with enzymatic activities have traditionally been annotated using reference vocabularies such as the hierarchical enzyme classification of the Enzyme Nomenclature Committee of the IUBMB + (often referred to as Enzyme Commission or EC numbers; https://enzyme.expasy.org/). EC numbers are manually curated in Swiss-Prot ('UniProt Reviewed') entries and added automatically to + TrEMBL ('UniProt Uneviewed') entries. A mapping between EC numbers and GO Molecular Function terms is maintainted by GO editors. UniProt entries assigned with an EC number + with a GO mapping are automatically annotated with the correponding GO term, as described in PMID:30395331. GO annotations using this method receive the evidence code + Inferred from Electronic Annotation (IEA). This method has been evaluated at up to 100% accurate (Camon et. al. 2005). The EC2GO mapping file is available at + http://current.geneontology.org/ontology/external2go/ec2go. alt_id: - GO_REF:0000005 - authors: GOA curators, MGI curators - citation: PMID:11374909 - external_accession: - - MGI:2152096 - - J:72245 - - ZFIN:ZDB-PUB-031118-3 - - SGD_REF:S000124037 + authors: GO Central curators + citation: PMID:31688925 is_obsolete: false year: 2001 - id: GO_REF:0000004