diff --git a/CHANGELOG.md b/CHANGELOG.md
index a02fe321d..2e8f349c0 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -3,7 +3,7 @@
 ## 1.16.0
 
 ### Features
-- Add a tifffile tile source ([885](../../pull/885))
+- Add a tifffile tile source ([885](../../pull/885), [896](../../pull/896))
 
 ### Improvements
 - Pass options to the annotationLayer mode ([881](../../pull/881))
diff --git a/sources/tifffile/large_image_source_tifffile/__init__.py b/sources/tifffile/large_image_source_tifffile/__init__.py
index dc50db9bd..1d6e7ab64 100644
--- a/sources/tifffile/large_image_source_tifffile/__init__.py
+++ b/sources/tifffile/large_image_source_tifffile/__init__.py
@@ -72,6 +72,7 @@ class TifffileFileTileSource(FileTileSource, metaclass=LruCacheMetaclass):
 
     # Fallback for non-tiled or oddly tiled sources
     _tileSize = 512
+    _minImageSize = 128
     _minTileSize = 128
     _maxTileSize = 2048
     _maxAssociatedImageSize = 8192
@@ -161,6 +162,9 @@ def _findMatchingSeries(self):
                         skip = True
                 if skip:
                     continue
+            if (s.shape[s.axes.index('X')] < min(self.sizeX, self._minImageSize) and
+                    s.shape[s.axes.index('Y')] < min(self.sizeY, self._minImageSize)):
+                continue
             self._series.append(idx)
             self._seriesShape.append({
                 'sizeX': s.shape[s.axes.index('X')], 'sizeY': s.shape[s.axes.index('Y')]})