diff --git a/sources/nd2/large_image_source_nd2/__init__.py b/sources/nd2/large_image_source_nd2/__init__.py
index 420d9539a..2ec505b05 100644
--- a/sources/nd2/large_image_source_nd2/__init__.py
+++ b/sources/nd2/large_image_source_nd2/__init__.py
@@ -134,12 +134,12 @@ def __init__(self, path, **kwargs):
 
         _lazyImport()
         try:
-            # We use dask to allow lazy reading of large images
-            self._nd2 = nd2.ND2File(self._largeImagePath)
+            self._nd2 = nd2.ND2File(self._largeImagePath, validate_frames=True)
         except Exception:
             if not os.path.isfile(self._largeImagePath):
                 raise TileSourceFileNotFoundError(self._largeImagePath) from None
             raise TileSourceError('File cannot be opened via nd2reader.')
+        # We use dask to allow lazy reading of large images
         self._nd2array = self._nd2.to_dask(copy=False)
         arrayOrder = list(self._nd2.sizes)
         # Reorder this so that it is XY (P), T, Z, C, Y, X, S (or at least end
diff --git a/sources/nd2/setup.py b/sources/nd2/setup.py
index bc2dc699d..58dd380c1 100644
--- a/sources/nd2/setup.py
+++ b/sources/nd2/setup.py
@@ -53,7 +53,7 @@ def prerelease_local_scheme(version):
     install_requires=[
         f'large-image{limit_version}',
         'dask[array]',
-        'nd2[legacy]<0.2.3 ; python_version >= "3.7"',
+        'nd2[legacy]>=0.2.3 ; python_version >= "3.7"',
         'importlib-metadata ; python_version < "3.8"',
     ],
     extras_require={