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<!DOCTYPE html>
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<head>
<meta charset="utf-8">
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<title>resume</title>
<meta name="viewport" content="width=device-width, initial-scale=1.0">
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/*
This document has been created with Marked.app <http://markedapp.com>, Copyright 2011 Brett Terpstra
Please leave this notice in place, along with any additional credits below.
---------------------------------------------------------------
Title: hartzell-resume
Author: Brett Terpstra
Description: Hartzell's hacked Github README style. See github style.
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<h1 style="text-align:center" id="georgehartzell">George Hartzell</h1>
<p style="text-align:center;" class="noPrint">
<img src="telefest.jpg" style="width:768px;" class="noprint">
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<ul>
<li>Email: <code>hartzell at alerce.com</code></li>
<li>Home: 5767 Mendocino Ave, Oakland, CA 94618</li>
<li>Phone: 510.985.2753</li>
</ul>
<h2 id="profile">Profile</h2>
<p>Real-world engineering and management experience in successful startups,
dot-com ephemera, corporate behemoths and ivory tower academia. PhD in
Computer Science with computational biology publications spanning more than
twenty years.</p>
<p>Proven ability to blend computer science, applied engineering and molecular
biology to produce effective solutions to real problems.</p>
<p>“… excellent at building and maintaining relationships with peers, direct
reports, other leaders in the organization, and technology/service partners.”
[Suzy Brown, CEO, Atlantes Services]</p>
<h2 id="experience">Experience</h2>
<h3 id="principalcomputationalbiologist">Principal Computational Biologist</h3>
<p><strong>Genentech, South San Francisco, CA 2010–2012</strong></p>
<p>Assembled and led the team that managed and analyzed hundreds of
terabytes of next-generation sequencing data for several thousand
samples. Assembled and led the team that curated, analyzed, and
published mutation data produced using various technologies over the
preceding decade. Managed the department’s contributions to the
company-wide effort to modernize its antibody engineering processes.
Managed the Research division’s in-house operations team and
represented Research to the corporate computing organizations. Member
of the Senior Staff and the Technical Steering Committee. Sponsored/drove
migrations to modern source control systems, continuous integration
systems, and automated deployment processes. Invited to represent
Senior Staff at staff development events. Mentor to several
programmer analysts and computational biologists.</p>
<h3 id="principalprogrammeranalyst">Principal Programmer Analyst</h3>
<p><strong>Genentech, South San Francisco, CA 2009</strong></p>
<p>Led the ongoing development of Genentech’s Mutation, Variation, and
Polymorphism platform, including reverse engineering and rescuing
existing data, developing a reliable set of data storage and analysis
tools, and deploying those tools as both a production platform and an
ad-hoc research tool.</p>
<h3 id="principal">Principal</h3>
<p><strong>GH LLC, Oakland, CA 2005-Current</strong></p>
<p>GH, LLC provides a variety of scientific, engineering, and management
services to biotech and dot-com clients. Recent engagements include
engineering and computational biology projects at <strong>Nebula</strong>,
<strong>Genentech</strong> and <strong>Bayer Healthcare Pharmaceuticals</strong>. Past projects
include: Senior Technical Advisor to the COO at <strong>HHMI’s Janelia Farm
Research Campus</strong>, recruiting a new Director of Scientific Computing &
IT and helping with the interim management of the department;
computational biology and automation projects at <strong>Schering AG</strong>;
reviewing and critiquing the management and technical infrastructure
of the computing groups within the six departments that make up the
Life Sciences Division at <strong>Harvard University</strong>; and re-engineering
Mark Yandell’s Comparative Genomics Library at the <strong>Berkeley
Drosophila Genome Project</strong>.</p>
<h3 id="scientificprogrammer">Scientific Programmer</h3>
<p><strong>Berkeley Drosophila Genome Project, Berkeley, CA 2002–2005</strong></p>
<p>Built and deployed flexible and reliable automation tools for large-scale
genome analyses; mentored postdoctoral students, including directed readings,
code reviews, and collaborative coding and debugging sessions; collaborated on
various research projects.</p>
<h3 id="vpengineeringdirectorserviceops">VP Engineering/Director Service Ops</h3>
<p><strong>Atlantes Services Inc., Menlo Park, CA 1999–2001</strong></p>
<p>Built the engineering team (including firmware engineers, application
programmers, build/release engineers, and engineering management) for a
product with wide-area wireless, web access, and embedded hardware components.
Built and out-sourced our 24x7 commercial service. The service resided at a
co-location facility, using their resources plus a dedicated connection to a
nation-wide wireless network. Day-to-day operations were outsourced and
overseen by a member of my team. Led the engineering effort that implemented
the framework at the core of the company’s offering and oversaw its ongoing
development. Participated in the management team, establishing company goals
and direction. Instrumental in acquiring first round financing in a difficult
funding environment (November, 2000).</p>
<h3 id="seniorserverengineer">Senior Server Engineer</h3>
<p><strong>WebTV Networks/Microsoft, Mountain View, CA 1996–1999</strong></p>
<p>As an early employee at WebTV Networks I played a variety of operational and
engineering roles as the company grew. Designed and built out the first two
WebTV service facilities and played a key role in the later facilities.
Designed and implemented the email architecture that scaled to over 1,000,000
customers. Owned, maintained, and extended several components of the
UNIX-based service.</p>
<h3 id="principal">Principal</h3>
<p><strong>Alerce Consulting, Berkeley, CA 1992–1996</strong></p>
<p>Provided support for computational biology tools, Internet connectivity and
security, computational infrastructure and operations. Biotechnology clients
included Genentech, Mercator Genetics, DNAX, Pangea Systems and Neomorphic
Software. Software clients included Illustra Information Technologies,
Netscape Communications and Streetlight Software.</p>
<h3 id="computationalgroupleader">Computational Group Leader</h3>
<p><strong>Stanford Yeast Genome Project, Stanford, CA 1991–1992</strong></p>
<p>Responsible for the computational components of Stanford’s effort to sequence
the yeast genome. Designed the computing facility for the project and several
affiliated labs. Acquired, ported, designed and implemented assembly and
analysis tools to support the sequencing effort. Oversaw the development of
software to integrate several robotic devices [Beckman Biomek, ABI Catalyst]
into the project’s workflow. Wrote, submitted, championed and won a $300,000
grant from Digital Equipment Corporation. Managed an operations team that
supported UNIX, VMS, Macintosh and PC systems.</p>
<h3 id="systemmanagerapplicationprogrammer">System Manager/Application Programmer</h3>
<p><strong>MCD Biology, U. of CO, Boulder, CO 1986–1991</strong></p>
<p>Built the department’s computing facility and collaborated with Gary Stormo on
his research projects. Responsible for hardware and systems software
selection and maintenance, application programming and user support. Upgraded
the facility from a single Pyramid 90x using serial terminals to a distributed
facility built around a MIPS M–2000 and independent workstations. The
facility provided tools for sequence analysis, data analysis, database
management, and text processing for the department.</p>
<h2 id="education">Education</h2>
<h3 id="phdcomputerscience2001--universityofcaliforniaberkeleyca">PhD Computer Science, 2001 – <em>University of California, Berkeley, CA</em></h3>
<h3 id="mscomputerscience1989--universityofcoloradoboulderco">MS, Computer Science, 1989 – <em>University of Colorado, Boulder, CO</em></h3>
<h3 id="babiology1984--swarthmorecollegeswarthmorepa">BA, Biology, 1984 – <em>Swarthmore College, Swarthmore, PA</em></h3>
<h2 id="publications">Publications</h2>
<h3 id="yandelletal.">Yandell <em>et al.</em></h3>
<p>Yandell MD, Mungall CJ, Prochnik S, Smith C, Kaminker J, Hartzell G,
Lewis S, Rubin GM. Large-Scale Trends in the Evolution of Gene
Structures within 11 Animal Genomes. <em>PLoS Computational Biology</em>,
2(3), March 2006.</p>
<h3 id="reeseetal.">Reese <em>et al.</em></h3>
<p>Reese M, Hartzell G, Harris N, Ohler U, Abril J,
Lewis S. Genome annotation assessment in Drosophila melanogaster.
<em>Genome Research</em>, 10(4):483–501, April 2000.</p>
<h3 id="reeseetal.">Reese <em>et al.</em></h3>
<p>Reese M, Harris N, Hartzell G, Ohler U, Lewis S. <em>ISMB ’99 Tutorial</em>.
The challenge of annotating a complete eukaryotic genome: A case study
in Drosophila melanogaster. A tutorial given at ISMB 1999 in
Heidelberg, Germany.</p>
<h3 id="ashburneretal.">Ashburner <em>et al.</em></h3>
<p>Ashburner M, et al. An exploration of the sequence of a 2.9-Mb region
of the genome of Drosophila melanogaster: the Adh region. <em>Genetics</em>,
153(1):179–219, September 1999.</p>
<h3 id="floreaetal.">Florea <em>et al.</em></h3>
<p>Florea L, Hartzell G, Zhang Z, Rubin G, Miller W. A computer program
for aligning a cDNA sequence with a genomic DNA sequence. <em>Genome
Research</em>, 8(9):967–974, September 1998.</p>
<h3 id="dietrichetal.">Dietrich <em>et al.</em></h3>
<p>Dietrich F, et al. The nucleotide sequence of Saccharomyces
cerevisiae chromosome V. <em>Nature</em>, 387:78–81, May 1997.</p>
<h3 id="lipschutzetal.">Lipschutz <em>et al.</em></h3>
<p>Lipschutz R, Taverner F, Hennesy K, Hartzell G, Davis R. DNA sequence
confidence estimation. <em>Genomics</em>, 19(3):417–424, February 1994.</p>
<h3 id="hertzetal.">Hertz <em>et al.</em></h3>
<p>Hertz G, Hartzell G, Stormo G. Identification of consensus patterns
in unaligned DNA sequences known to be functionally related.
<em>Computer Applications in the Biosciences</em>, 6(2):81–92, April 1990.</p>
<h3 id="scottetal.">Scott <em>et al.</em></h3>
<p>Scott M,
Tamkun, J, Hartzell G. The structure and function of the homeodomain.
<em>Biochimica et Biophysica Acta: Reviews on Cancer</em>, 989(1):25–48, July
1989.</p>
<h3 id="stormoetal.">Stormo <em>et al.</em></h3>
<p>Stormo G, Hartzell G. Identifying protein-binding sites from
unaligned DNA fragments. <em>Proceedings of the National Academy of
Sciences</em>, 86(4):1183–1187, February 1989.</p>
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